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Sowohl die SBAS als auch chronische Lungenerkrankungen verursachen hypoxämische Zustände bei den betroffenen Patienten, was zu pathophysiologischen Veränderungen führt, für die Zusammenhänge mit kardiovaskulären Erkrankungen bekannt sind. Auch für eine erhöhte Inzidenz von Malignomen per se und speziell das Lungenkarzinom sind chronische Lungenerkrankungen wie die COPD (chronisch obstruktive Lungenerkrankung), aber auch SBAS als assoziiert beschrieben. Die bisher bekannten Zusammenhänge und pathophysiologischen Mechanismen sollen in diesem Beitrag dargestellt werden. Die SBAS können sich in unterschiedlichen Formen als intermittierende und\u002Foder chronische Hypoxämie manifestieren. Diese Hypoxämiephänotypen haben Auswirkungen auf vaskuläre Wachstumsfaktoren und auf die Tumorzellproliferation. Die Exposition humaner Lungenkarzinomzellen (menschliches Adenokarzinom Zelllinie: H1437, menschliches Plattenepithelkarzinom Zelllinie: H520) gegenüber einer Hypoxämie führt zu signifikant erhöhten Proliferationsraten mit noch unbekannten Effekten auf das Therapieansprechen und den Langzeitverlauf. Ebenso sind die klinischen Effekte von SBAS und Hypoxämiephänotypen auf den unmittelbaren postoperativen Verlauf nach anatomischen Lungenresektionen bei Lungenkarzinompatienten bislang ungeklärt.",{"EN":101},"Schlafbezogene Atmungsstörungen, Hypoxämie und der Zusammenhang mit dem Lungenkarzinom",{"VOID":103},"[]",{"VOID":105},"Heinzer R, Vat S, Marques-Vidal P et al (2015) Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med 3:310–318. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs2213-2600(15)00043-0\nSateia MJ (2014) International classification of sleep disorders-third edition: highlights and modifications. Chest 146:1387–1394. https:\u002F\u002Fdoi.org\u002F10.1378\u002Fchest.14-0970\nPeppard PE, Young T, Barnet JH et al (2013) Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177:1006–1014. https:\u002F\u002Fdoi.org\u002F10.1093\u002Faje\u002Fkws342\nPunjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5:136–143. https:\u002F\u002Fdoi.org\u002F10.1513\u002Fpats.200709-155MG\nChan MTV, Wang CY, Seet E et al (2019) Association of unrecognized obstructive sleep apnea with postoperative cardiovascular events in patients undergoing major noncardiac surgery. JAMA 321:1788–1798. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjama.2019.4783\nTafelmeier M, Luft L, Zistler E et al (2021) Central sleep apnea predicts pulmonary complications after cardiac surgery. Chest 159:798–809. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.chest.2020.07.080\nTafelmeier M, Knapp M, Lebek S et al (2019) Predictors of delirium after cardiac surgery in patients with sleep disordered breathing. Eur Respir J. https:\u002F\u002Fdoi.org\u002F10.1183\u002F13993003.00354-2019\nErman MK, Stewart D, Einhorn D et al (2007) Validation of the ApneaLink for the screening of sleep apnea: a novel and simple single-channel recording device. J Clin Sleep Med 3:387–392\nLinz D, Colling S, Nussstein W et al (2018) Nocturnal hypoxemic burden is associated with epicardial fat volume in patients with acute myocardial infarction. Sleep Breath 22:703–711. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11325-017-1616-0\nKhoshkish S, Hohl M, Linz B et al (2018) The association between different features of sleep-disordered breathing and blood pressure: a cross-sectional study. J Clin Hypertens (Greenwich) 20:575–581. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjch.13202\nLinz D, Malfertheiner MV, Werner N et al (2021) Nocturnal hypoxemic burden during positive airway pressure treatment across different central sleep apnea etiologies. Sleep Med 79:62–70. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.sleep.2021.01.007\nBaumert M, Immanuel SA, Stone KL et al (2020) Composition of nocturnal hypoxaemic burden and its prognostic value for cardiovascular mortality in older community-dwelling men. Eur Heart J 41:533–541. https:\u002F\u002Fdoi.org\u002F10.1093\u002Feurheartj\u002Fehy838\nCampos-Rodriguez F, Martinez-Garcia MA, Martinez M et al (2013) Association between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort. Am J Respir Crit Care Med 187:99–105. https:\u002F\u002Fdoi.org\u002F10.1164\u002Frccm.201209-1671OC\nNieto FJ, Peppard PE, Young T et al (2012) Sleep-disordered breathing and cancer mortality: results from the Wisconsin sleep cohort study. Am J Respir Crit Care Med 186:190–194. https:\u002F\u002Fdoi.org\u002F10.1164\u002Frccm.201201-0130OC\nCheong AJY, Tan BKJ, Teo YH et al (2021) Obstructive sleep apnea and lung cancer: a systematic review and meta-analysis of 4,885,518 participants. Ann Am Thorac Soc. https:\u002F\u002Fdoi.org\u002F10.1513\u002FAnnalsATS.202108-960OC\nDreher M, Kruger S, Schulze-Olden S et al (2018) Sleep-disordered breathing in patients with newly diagnosed lung cancer. BMC Pulm Med 18:72. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12890-018-0645-1\nDutkowska AE, Antczak A (2016) Comorbidities in lung cancer. Pneumonol Alergol Pol 84:186–192. https:\u002F\u002Fdoi.org\u002F10.5603\u002FPiAP.2016.0022\nAlmendros I, Montserrat JM, Ramírez J et al (2012) Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoea. Eur Respir J 39:215–217. https:\u002F\u002Fdoi.org\u002F10.1183\u002F09031936.00185110\nMartinez-Garcia MA, Martorell-Calatayud A, Nagore E et al (2014) Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanoma. Eur Respir J 43:1661–1668. https:\u002F\u002Fdoi.org\u002F10.1183\u002F09031936.00115413\nDriendl S, Arzt M, Zimmermann CS et al (2021) Sleep apnoea and incident malignancy in type 2 diabetes. ERJ Open Res. https:\u002F\u002Fdoi.org\u002F10.1183\u002F23120541.00036-2021\nAlmendros I, Montserrat JM, Torres M et al (2012) Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea. Sleep Med 13:1254–1260. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.sleep.2012.08.012\nSomers VK, Dyken ME, Clary MP et al (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96:1897–1904. https:\u002F\u002Fdoi.org\u002F10.1172\u002Fjci118235\nZheng J, Almendros I, Wang Y et al (2015) Reduced NADPH oxidase type 2 activity mediates sleep fragmentation-induced effects on TC1 tumors in mice. OncoImmunology 4:e976057. https:\u002F\u002Fdoi.org\u002F10.4161\u002F2162402X.2014.976057\nHakim F, Wang Y, Zhang SX et al (2014) Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling. Cancer Res 74:1329–1337. https:\u002F\u002Fdoi.org\u002F10.1158\u002F0008-5472.CAN-13-3014\nMiao ZF, Zhao TT, Wang ZN et al (2014) Influence of different hypoxia models on metastatic potential of SGC-7901 gastric cancer cells. Tumour Biol 35:6801–6808. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs13277-014-1928-7\nToffoli S, Michiels C (2008) Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours. FEBS J 275:2991–3002. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1742-4658.2008.06454.x\nLévy P, Kohler M, McNicholas WT et al (2015) Obstructive sleep apnoea syndrome. Nat Rev Dis Primers 1:15015. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnrdp.2015.15\nFederico A, Morgillo F, Tuccillo C et al (2007) Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer 121:2381–2386. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fijc.23192\nYamauchi M, Nakano H, Maekawa J et al (2005) Oxidative stress in obstructive sleep apnea. 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J Thorac Oncol 5(2):220–228\nWu YL et al (2020) Osimertinib in resected EGFR-mutated non-small-cell lung cancer. N Engl J Med 383(18):1711–1723\nFelip E et al (2021) Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial. Lancet 398(10308):1344–1357\nForde PM et al (2022) Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer. N Engl J Med 386(21):1973–1985\nAntonia SJ et al (2017) Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. N Engl J Med 377(20):1919–1929\nRemon J et al (2022) Current challenges of unresectable stage III NSCLC: are we ready to break the glass ceiling of the PACIFIC trial? Ther Adv Med Oncol 14:17588359221113268\nFrost N et al (2020) Pemetrexed-based chemotherapy is inferior to pemetrexed-free regimens in thyroid transcription factor 1 (TTF-1)-negative, EGFR\u002FALK-negative lung Adenocarcinoma: a propensity score matched pairs analysis. Clin Lung Cancer 21(6):e607–e621\nReck M et al (2016) Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med 375(19):1823–1833\nJassem J et al (2021) Updated overall survival analysis from IMpower110: atezolizumab versus platinum-based chemotherapy in treatment-naive programmed death-Ligand 1‑selected NSCLC. J Thorac Oncol 16(11):1872–1882\nSezer A et al (2021) Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50 %: a multicentre, open-label, global, phase 3, randomised, controlled trial. Lancet 397(10274):592–604\nGandhi L et al (2018) Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N Engl J Med 378(22):2078–2092\nWest H et al (2019) Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 20(7):924–937\nSocinski MA et al (2018) Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC. N Engl J Med 378(24):2288–2301\nPaz-Ares L et al (2021) First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial. Lancet Oncol 22(2):198–211\nPaz-Ares L et al (2018) Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N Engl J Med 379(21):2040–2051\nRudin CM et al (2022) LBA8507 ASCO2022: SKYSCRAPER-02: primary results of a phase III, randomized, double-blind, placebo-controlled study of atezolizumab (atezo) + carboplatin + etoposide (CE) with or without tiragolumab (tira) in patients (pts) with untreated extensive-stage small cell lung cancer (ES-SCLC). JCO. https:\u002F\u002Fdoi.org\u002F10.1200\u002FJCO.2022.40.17_suppl.LBA8507\nHorn L et al (2018) First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer. N Engl J Med 379(23):2220–2229\nGoldman JW et al (2021) Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 22(1):51–65\nBonney A et al (2022) Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality. Cochrane Database Syst Rev. https:\u002F\u002Fdoi.org\u002F10.1002\u002F14651858.CD013829.pub2\nEbell MH, Bentivegna M, Hulme C (2020) Cancer-specific mortality, all-cause mortality, and overdiagnosis in lung cancer screening trials: a meta-analysis. Ann Fam Med 18(6):545–552\nNational Lung Screening Trial Research (2011) Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365(5):395–409\nde Koning HJ et al (2020) Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med 382(6):503–513\nBecker N et al (2020) Lung cancer mortality reduction by LDCT screening-Results from the randomized German LUSI trial. Int J Cancer 146(6):1503–1513\nForce USPST et al (2021) Screening for lung cancer: US preventive services task force recommendation statement. JAMA 325(10):962–970\nPotter AL et al (2022) Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study. BMJ 376:e69008\nKauczor HU et al (2020) ESR\u002FERS statement paper on lung cancer screening. Eur Respir J. https:\u002F\u002Fdoi.org\u002F10.1183\u002F13993003.00506-2019\nHerth FJF et al (2019) Joint Statement of the German Radiological Society and the German Respiratory Society on a Quality-Assured Early Detection Program for Lung Cancer with Low-dose CT. Pneumologie 73(10):573–577",{"VOID":446},"10.1007\u002Fs10405-022-00481-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10405-022-00481-x",[449,464],{"id":450,"sortIndex":21,"researcher":20,"roles":451,"affiliations":452,"properties":461},"ea391c97-041c-453d-b7ac-810c45403e75",[117],[453],{"id":454,"sortIndex":21,"affiliation":455,"properties":20},"f053be56-2ae0-4fb0-8e40-0578977e6082",{"id":454,"createTime":20,"updateTime":20,"relativeEntities":456,"slug":20,"properties":457,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":460,"statistic":20},[],{"title":458},{"EN":459},"Medizinische Klinik m. S. Infektiologie und Pneumologie, Charité Universitätsmedizin Berlin, Berlin, Deutschland",[],{"title":462},{"VI":463},"Matthias Raspe",{"id":465,"sortIndex":83,"researcher":20,"roles":466,"affiliations":467,"properties":474},"9302e3d1-7837-4870-883c-fbaaef13f5f5",[117],[468],{"id":454,"sortIndex":21,"affiliation":469,"properties":20},{"id":454,"createTime":20,"updateTime":20,"relativeEntities":470,"slug":20,"properties":471,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":473,"statistic":20},[],{"title":472},{"EN":459},[],{"title":475},{"VI":476},"Nikolaj Frost",{"url":447,"publisher":478,"properties":518},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":479,"slug":10,"properties":480,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":484,"manageAffiliations":493,"indexDatabases":499,"url":78,"thumbnailPath":20,"statistic":513,"gsStatistic":20,"type":86,"analyzePriority":20},[],{"issn":481,"title":482,"eissn":483},{"VOID":13},{"EN":15},{"VOID":17},[485,489],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":486,"label":487,"description":488,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":490,"label":491,"description":492,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},[494],{"id":37,"createTime":20,"updateTime":20,"relativeEntities":495,"slug":20,"properties":496,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":498,"statistic":20},[],{"title":497},{"EN":41},[43],[500,506],{"id":46,"indexDatabase":501,"url":57,"indexYears":58,"academicFieldIds":20,"indexDatabaseRanking":59},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":502,"label":503,"description":504,"key":54,"publicationTags":505,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],{"id":61,"indexDatabase":507,"url":74,"indexYears":20,"academicFieldIds":512,"indexDatabaseRanking":20},{"id":63,"createTime":20,"updateTime":20,"relativeEntities":508,"label":509,"description":510,"key":70,"publicationTags":511,"standard":20},[],{"EN":66,"VI":66},{"EN":68,"VI":69},[72,73],[76,77],{"impactFactor":21,"impactFactorByYear":514,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":81,"totalPublicationByYear":515,"totalCitation":21,"totalCitationByYear":516,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":517,"hindexLast5Year":21,"hindex":21},{},{"2022":83,"2023":83},{},{},{"pages":519,"volume":521},{"VOID":520},"11-19",{"VOID":428},"2022-12-20",[72,56],{"id":525,"createTime":526,"updateTime":527,"relativeEntities":528,"slug":529,"properties":530,"entityType":108,"verifyStatus":109,"verifyTime":527,"verifyNote":111,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":541,"fullTextUrl":20,"authors":542,"publicationType":209,"publisherRelationship":573,"citationCount":20,"citationInfo":20,"publishDate":614,"publishYear":615,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":616,"openAccess":20,"references":20,"isForceReanalyzing":260},"7319632d-fec5-47bf-b42c-baa58bc6a610","2024-04-06T20:03:55.304+00:00","2025-02-25T03:55:17.340+00:00",[],"Asthma-in-Klinik-und-Praxis",{"abstract":531,"title":533,"keywords":535,"references":537,"doi":539},{"EN":532},"Asthma ist eine klinische Diagnose, wobei aktuelle Leitlinien ergänzend zur Beurteilung der Lungenfunktion die Berücksichtigung der Typ-2-Biomarker Eosinophile im Blut und Fraktion des exhalierten Stickstoffmonoxids („fraction of exhaled nitric oxide“, FeNO) empfehlen. Eine Phänotypisierung der Asthmaerkrankung auf Grundlage von Anamnese (u. a. Allergie), Biomarkern und Komorbiditäten ist Voraussetzung einer personalisierten Therapie. Inhalative Glukokortikoide (Inhaled corticosteroids, ICS) sind die in jeder Therapiestufe zu bevorzugende Basis der Therapie: Diese werden mit zunehmendem Asthmaschweregrad ergänzt durch lang wirksame Bronchodilatatoren und bei schwerem Asthma durch monoklonale Antikörper, die gegen Schlüsselmediatoren der asthmatischen Entzündung gerichtet sind (Biologika). Die enormen Fortschritte in der Therapie haben zu einer sehr guten Asthmakontrolle bei der sehr großen Mehrheit der Patientinnen und Patienten geführt, sodass die Asthmaerkrankung heute eine Domäne der ambulanten fachärztlichen Versorgung ist.",{"EN":534},"Asthma in Klinik und Praxis",{"EN":536},"",{"VOID":538},"Lommatzsch M, Buhl R, Korn S (2020) The treatment of mild and moderate asthma in adults. Dtsch Ärztebl Int 117:434–444. https:\u002F\u002Fdoi.org\u002F10.3238\u002Farztebl.2020.0434\nBundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) (2020) Nationale VersorgungsLeitlinie Asthma – Langfassung, 4. Auflage. Version 1. https:\u002F\u002Fdoi.org\u002F10.6101\u002FAZQ\u002F000469. https:\u002F\u002Fwww.asthma.versorgungsleitlinien.de.\nLommatzsch M, Criee CP, de Jong CCM et al (2023) Diagnosis and treatment of asthma: a guideline for respiratory specialists 2023—published by the German Respiratory Society (DGP) e. V. Pneumologie 77:461–543. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fa-2070-2135\nAaron SD, Vandemheen KL, FitzGerald JM et al (2017) Reevaluation of diagnosis in adults with physician-diagnosed asthma. JAMA 317:269–279. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjama.2016.19627\nLouis R, Satia I, Ojanguren I et al (2022) European respiratory society guidelines for the diagnosis of asthma in adults. Eur Respir J. https:\u002F\u002Fdoi.org\u002F10.1183\u002F13993003.01585-2021\nKopp MV, Muche-Borowski C, Abou-Dakn M et al (2022) S3 guideline allergy prevention. Allergol Sel 6:61–97. https:\u002F\u002Fdoi.org\u002F10.5414\u002FALX02303E\nPfaar O, Ankermann T, Augustin M et al (2022) Guideline on allergen immunotherapy in IgE-mediated allergic diseases: S2K Guideline of the German Society of Allergology and Clinical Immunology (DGAKI), Society of Pediatric Allergology and Environmental Medicine (GPA), Medical Association of German Allergologists (AeDA), Austrian Society of Allergology and Immunology (OGAI), Swiss Society for Allergology and Immunology (SSAI), German Dermatological Society (DDG), German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), German Society of Pediatrics and Adolescent Medicine (DGKJ), Society of Pediatric Pulmonology (GPP), German Respiratory Society (DGP), German Professional Association of Otolaryngologists (BVHNO), German Association of Paediatric and Adolescent Care Specialists (BVKJ), Federal Association of Pneumologists, Sleep and Respiratory Physicians (BdP), Professional Association of German Dermatologists (BVDD). Allergol Sel 6:167–232. https:\u002F\u002Fdoi.org\u002F10.5414\u002FALX02331E\nLommatzsch M, Brusselle GG, Canonica GW et al (2022) Disease-modifying anti-asthmatic drugs. Lancet 399:1664–1668. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(22)00331-2\nNathan et al (2004) Development of the Asthma Control Test: A survey for assessing asthma control. American Academy of Allergy, Asthma and Immunology. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jaci.2003.09.008\nJuniper EF, O’Byrne PM, Guyatt GH, Ferrie PJ, King DR (1999) Development and validation of a questionnaire to measure asthma control. Eur Respir J 14:902–907.\nGINA, GIfA (2023) Global strategy for asthma management and prevention (www.ginasthma.org)\nNwaru BI, Ekstrom M, Hasvold P et al (2020) Overuse of short-acting beta(2)-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme. Eur Respir J. https:\u002F\u002Fdoi.org\u002F10.1183\u002F13993003.01872-2019\nBeasley R, Holliday M, Reddel HK et al (2019) Controlled trial of budesonide-formoterol as needed for mild asthma. N Engl J Med 380:2020–2030. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1901963\nO’Byrne PM, FitzGerald JM, Bateman ED et al (2018) Inhaled combined budesonide-formoterol as needed in mild asthma. N Engl J Med 378:1865–1876. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1715274\nReddel HK, FitzGerald JM, Bateman ED et al (2019) GINA 2019: a fundamental change in asthma management: treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents. Eur Respir J. https:\u002F\u002Fdoi.org\u002F10.1183\u002F13993003.01046-2019\nReddel HK, Busse WW, Pedersen S et al (2017) Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study. Lancet 389:157–166. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(16)31399-X\nSobieraj DM, Weeda ER, Nguyen E et al (2018) Association of inhaled corticosteroids and long-acting beta-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma: a systematic review and meta-analysis. JAMA 319:1485–1496. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjama.2018.2769\nBeasley R, Harper J, Bird G et al (2019) Inhaled corticosteroid therapy in adult asthma. Time for a new therapeutic dose terminology. Am J Respir Crit Care Med 199:1471–1477. https:\u002F\u002Fdoi.org\u002F10.1164\u002Frccm.201810-1868CI\nLee LA, Bailes Z, Barnes N et al (2021) Efficacy and safety of once-daily single-inhaler triple therapy (FF\u002FUMEC\u002FVI) versus FF\u002FVI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. Lancet Respir Med 9:69–84. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS2213-2600(20)30389-1\nJackson DJ, Heaney LG, Humbert M et al (2024) Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study. Lancet 403:271–281. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(23)02284-5",{"VOID":540},"10.1007\u002Fs10405-024-00546-z","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10405-024-00546-z",[543,558],{"id":544,"sortIndex":21,"researcher":20,"roles":545,"affiliations":546,"properties":555},"15e7fe3b-84cd-4615-b125-dd687df82c91",[117],[547],{"id":548,"sortIndex":21,"affiliation":549,"properties":20},"4d6b82bf-763e-46fc-a508-27e7063f3ade",{"id":548,"createTime":20,"updateTime":20,"relativeEntities":550,"slug":20,"properties":551,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":554,"statistic":20},[],{"title":552},{"VI":553},"Klinik für Innere Medizin, Schwerpunkt Pneumologie, Universitätsklinikum Gießen und Marburg, Standort Marburg, Marburg, Deutschland",[],{"title":556},{"VI":557},"Timm Greulich",{"id":559,"sortIndex":83,"researcher":20,"roles":560,"affiliations":561,"properties":570},"041008ad-e838-43a2-bceb-dbf2c58b38e4",[117],[562],{"id":563,"sortIndex":21,"affiliation":564,"properties":20},"3f0f731f-7cfb-4578-b28c-da77a2f3b262",{"id":563,"createTime":20,"updateTime":20,"relativeEntities":565,"slug":20,"properties":566,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":569,"statistic":20},[],{"title":567},{"VI":568},"Klinik für Pneumologie, Zentrum für Thoraxerkrankungen, Universitätsmedizin Mainz, Mainz, Deutschland",[],{"title":571},{"VI":572},"Roland Buhl",{"url":20,"publisher":574,"properties":20},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":575,"slug":10,"properties":576,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":580,"manageAffiliations":589,"indexDatabases":595,"url":78,"thumbnailPath":20,"statistic":609,"gsStatistic":20,"type":86,"analyzePriority":20},[],{"issn":577,"title":578,"eissn":579},{"VOID":13},{"EN":15},{"VOID":17},[581,585],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":582,"label":583,"description":584,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":586,"label":587,"description":588,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},[590],{"id":37,"createTime":20,"updateTime":20,"relativeEntities":591,"slug":20,"properties":592,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":594,"statistic":20},[],{"title":593},{"EN":41},[43],[596,602],{"id":46,"indexDatabase":597,"url":57,"indexYears":58,"academicFieldIds":20,"indexDatabaseRanking":59},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":598,"label":599,"description":600,"key":54,"publicationTags":601,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],{"id":61,"indexDatabase":603,"url":74,"indexYears":20,"academicFieldIds":608,"indexDatabaseRanking":20},{"id":63,"createTime":20,"updateTime":20,"relativeEntities":604,"label":605,"description":606,"key":70,"publicationTags":607,"standard":20},[],{"EN":66,"VI":66},{"EN":68,"VI":69},[72,73],[76,77],{"impactFactor":21,"impactFactorByYear":610,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":81,"totalPublicationByYear":611,"totalCitation":21,"totalCitationByYear":612,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":613,"hindexLast5Year":21,"hindex":21},{},{"2022":83,"2023":83},{},{},"2024-02-19",2024,[72,56],{"id":618,"createTime":619,"updateTime":620,"relativeEntities":621,"slug":622,"properties":623,"entityType":108,"verifyStatus":109,"verifyTime":620,"verifyNote":111,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":632,"fullTextUrl":20,"authors":633,"publicationType":209,"publisherRelationship":664,"citationCount":20,"citationInfo":20,"publishDate":709,"publishYear":430,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":710,"openAccess":20,"references":20,"isForceReanalyzing":260},"72ac10c0-8daa-405e-b33f-e59d764b50d3","2024-01-25T13:59:17.483+00:00","2025-02-23T11:51:43.840+00:00",[],"Sarkoidose-internationale-versus-deutsche-Leitlinien-zur-Behandlung-der-Sarkoidose",{"abstract":624,"title":626,"references":628,"doi":630},{"EN":625},"Im Jahr 2021 wurde eine internationale (ERS [Europäische Respiratorische Gesellschaft]) Leitlinie (LL) zur Behandlung der Sarkoidose publiziert. Im Jahr 2023 erfolgte eine deutsche S2k-LL zu dieser Thematik. Er erfolgt eine Bewertung der beiden neuen Leitlinien bezüglich Stärken und Schwächen insbesondere im Hinblick auf Anwendung in der klinischen Routine Es erfolgte eine Analyse der beiden Leitlinien zur Behandlung der Sarkoidose in Hinsicht auf die therapeutischen Fragestellungen und gegebenen Empfehlungen. In beiden Leitlinien wurden wichtige therapeutischen Fragestellungen nach dem GRADE-System mit entsprechender Graduierung beantwortet. Beide LL stimmen mit den Indikationsgründen zur Einleitung einer systemischen Steroidtherapie überein und berücksichtigen Prednisolon als Erstlinientherapie. Im Falle eines Progresses werden weitere Immunsuppressiva sowie Biologika, allein oder in Kombination mit Prednisolon, als Alternative empfohlen. Die Bewahrung bzw. Besserung der Lebensqualität der Patienten sowie der Organfunktion wird von beiden LL als zentrales Ziel der Behandlung betrachtet. Einschränkungen beider LL liegen an fehlenden Empfehlungen zur Behandlung der Komplikationen, zur Transplantationslistung und zu nichtmedikamentösen Maßnahmen. Beide Leitlinien zur Behandlung der Sarkoidose geben einen sehr guten Überblick über die vorhandene Evidenz einzelner medikamentöser Therapien. Gravierende Abweichungen lassen sich nicht feststellen.",{"EN":627},"Sarkoidose: internationale versus deutsche Leitlinien zur Behandlung der Sarkoidose",{"VOID":629},"Costabel U, Wessendorf TE, Bonella F (2017) Epidemiologie und klinisches Erscheinungsbild der Sarkoidose. Klin Monbl Augenheilkd 234(06):790–795\nBaughman RP, Valeyre D, Korsten P, Mathioudakis AG, Wuyts WA, Wells A et al (2021) ERS clinical practice guidelines on treatment of sarcoidosis. Eur Respir J\nHunninghake GW, Costabel U, Ando M, Baughman R, Cordier JF, du Bois R et al (1999) ATS\u002FERS\u002FWASOG statement on sarcoidosis. American Thoracic Society\u002FEuropean Respiratory Society\u002FWorld Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis 16(2):149–173\nBaughman RP, Wells A (2019) Advanced sarcoidosis. Curr Opin Pulm Med 25(5):497–504\nKirkil G, Lower EE, Baughman RP (2018) Predictors of Mortality in Pulmonary Sarcoidosis. Chest 153(1):105–113\nBaughman RP, Barriuso R, Beyer K, Boyd J, Hochreiter J, Knoet C et al (2018) Sarcoidosis: patient treatment priorities. ERJ Open Res 4(4)\nRahaghi FF, Baughman RP, Saketkoo LA, Sweiss NJ, Barney JB, Birring SS et al (2020) Delphi consensus recommendations for a treatment algorithm in pulmonary sarcoidosis. Eur Respir Rev 29(155)\nVorselaars AD, Wuyts WA, Vorselaars VM, Zanen P, Deneer VH, Veltkamp M et al (2013) Methotrexate vs azathioprine in second-line therapy of sarcoidosis. Chest 144(3):805–812\nFlaherty KR, Wells AU, Cottin V, Devaraj A, Walsh SLF, Inoue Y et al (2019) Nintedanib in progressive fibrosing interstitial lung diseases. N Engl J Med 381(18):1718–1727\nBaughman RP, Gupta R, Judson MA, Lower EE, Stewart JI, Reeves R, Wells AU (2021) Pirfenidone for Progressive Fibrotic Sarcoidosis (PIRFS): Results of a Double Blind Placebo Controlled Pilot Study. Am J Respir Crit Care Med 203(9)\nBirnie DH, Sauer WH, Bogun F, Cooper JM, Culver DA, Duvernoy CS et al (2014) HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm 11(7):1305–1323\nKazmirczak F, Chen KA, Adabag S, von Wald L, Roukoz H, Benditt DG et al (2019) Assessment of the 2017 AHA\u002FACC\u002FHRS guideline recommendations for implantable cardioverter-defibrillator implantation in cardiac sarcoidosis. Circ Arrhythm Electrophysiol 12(9):e7488\nTrivieri MG, Spagnolo P, Birnie D, Liu P, Drake W, Kovacic JC et al (2020) Challenges in cardiac and pulmonary sarcoidosis: JACC state-of-the-Art review. J Am Coll Cardiol 76(16):1878–1901\nStern BJ, Royal W 3rd, Gelfand JM, Clifford DB, Tavee J, Pawate S et al (2018) Definition and consensus diagnostic criteria for neurosarcoidosis: from the neurosarcoidosis consortium consensus group. JAMA Neurol 75(12):1546–1553\nCohen Aubart F, Bouvry D, Galanaud D, Dehais C, Mathey G, Psimaras D et al (2017) Long-term outcomes of refractory neurosarcoidosis treated with infliximab. J Neurol 264(5):891–897\nGelfand JM (2021) Tumour necrosis factor inhibitor monotherapy for CNS neurosarcoidosis. J Neurol Neurosurg Psychiatry\nDrake WP, Culver DA, Baughman RP, Judson MA, Crouser ED, James WE et al (2021) Phase II investigation of the efficacy of antimycobacterial therapy in chronic pulmonary sarcoidosis. Chest 159(5):1902–1912\nWallaert B, Kyheng M, Labreuche J, Stelianides S, Wemeau L, Grosbois JM (2020) Long-term effects of pulmonary rehabilitation on daily life physical activity of patients with stage IV sarcoidosis: a randomized controlled trial. Respir Med Res 77:1–7\nStrookappe B, Swigris J, De Vries J, Elfferich M, Knevel T, Drent M (2015) Benefits of physical training in sarcoidosis. Lung 193(5):701–708\nTherapie der Sarkoidose Deutsche S2K-Leitlinie 2023 im Druck (Pneumologie)\nJudson MA (2022) The treatment of sarcoidosis: translating the European respiratory guidelines into clinical practice. Curr Opin Pulm Med 28(5):451–460\nKashyap S, Bhardwaj M (2022) New sarcoidosis guidelines: Are we near to perfection? Lung India 39(3):217–219\nKahlmann V, Moor CC, Miedema JR, Wijsenbeek MS (2022) Comparison of the treatment guidelines for sarcoidosis: common sense in the search for evidence. 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Da sich die Therapieansätze sowie Prognosen zwischen den Erkrankungen wesentlich unterscheiden, ist die korrekte Diagnosestellung von grundlegender Bedeutung. In der klinischen Routine spielt neben der Anamnese, der Klinik, den Laborbefunden und der Bronchoskopie die Bildgebung eine zentrale Rolle in der Diagnosefindung. Die Diagnose diffuser parenchymatöser Lungenerkrankungen stellt eine enorme Herausforderung sowohl für Kliniker, Radiologen als auch Pathologen dar und sollte daher bevorzugt im multidisziplinären Rahmen erfolgen. Da sich die Patienten häufig mit einer unspezifischen, respiratorischen Symptomatik präsentieren, ist das Thorax-Röntgen die erste bildgebende Methode, welche eingesetzt wird. Bereits hier sind oft die verschiedenen Muster diffuser parenchymatöser Lungenerkrankungen (z. B. Milchglasverdichtungen und Konsolidierungen), deren Verteilung (z. B. kranial-kaudal) sowie zusätzliche Befunde, wie mediastinale Lymphadenopathie, bereits erkennbar. Der bildgebende Referenzstandard und somit integraler Bestandteil bei der Beurteilung einer diffusen parenchymatösen Lungenerkrankung ist jedoch die hochauflösende („high resolution“, HR) Computertomographie (CT) des Thorax. In manchen Fällen ist das Muster der HR-CT pathognomonisch, in anderen jedoch unspezifisch für eine Erkrankung, sodass weitere diagnostische Schritte nötig sind.",{"EN":721},"Röntgenbefunde bei diffusen parenchymatösen Lungenerkrankungen",{"VOID":723},"Lynch J III, Weigt S, Fishbein M (2007) Diffuse parenchymal lung disease. Prog Respir Res 36:11–21\nRyu JH et al (2002) Diagnostic approach to the patient with diffuse lung disease. Mayo Clin Proc 77(11):1221–1227 (quiz 1227)\nRyu JH et al (2007) Diagnosis of interstitial lung diseases. Mayo Clin Proc 82(8):976–986\nNishino M, Itoh H, Hatabu H (2014) A practical approach to high-resolution CT of diffuse lung disease. Eur J Radiol 83(1):6–19\nWormanns D, Hamer OW (2015) Glossary of terms for thoracic imaging—German version of the Fleischner society recommendations. Rofo 187(8):638–661\nDiederich S (2010) High resolution computed tomography of the lungs: ground glass opacity and its differential diagnosis. Radiologe 50(12):1141–1152\nMueller-Mang C, Ringl H, Herold C (2017) Interstitial lung diseases. In: Nikolaou K, Bamberg F, Laghi A, Rubin GD (Hrsg) Multislice CT. Medical radiology. Springer, Cham, S 261–288 https:\u002F\u002Fdoi.org\u002F10.1007\u002F174_2017_151\nBoitsios G, Bankier AA, Eisenberg RL (2010) Diffuse pulmonary nodules. AJR Am J Roentgenol 194(5):W354–W366\nZompatori M et al (2004) Diagnostic imaging of diffuse infiltrative disease of the lung. Respiration 71(1):4–19\nMarten K (2009) Reticular pattern in thin-section CT: from morphology to differential diagnosis. Radiologe 49(9):873–881 (quiz 882)\nOikonomou A (2014) Role of imaging in the diagnosis of diffuse and interstitial lung diseases. Curr Opin Pulm Med 20(5):517–524\nHansell DM et al (2008) Fleischner Society: glossary of terms for thoracic imaging. Radiology 246(3):697–722\nRyu JH, Swensen SJ (2003) Cystic and cavitary lung diseases: focal and diffuse. Mayo Clin Proc 78(6):744–752\nCantin L, Bankier AA, Eisenberg RL (2010) Multiple cystlike lung lesions in the adult. AJR Am J Roentgenol 194(1):W1–W11\nWormanns D, Hamer O (2015) Glossar thoraxradiologischer Begriffe entsprechend der Terminologie der Fleischner Society. Rofo 187(08):638–661\nLynch DA et al (2018) Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. Lancet Respir Med 6(2):138–153\nTseng HJ et al (2017) Pulmonary function tests for the radiologist. Radiographics 37(4):1037–1058\nWestcott JL, Cole SR (1986) Traction bronchiectasis in end-stage pulmonary fibrosis. Radiology 161(3):665–669\nSouza CA et al (2006) Idiopathic interstitial pneumonias: prevalence of mediastinal lymph node enlargement in 206 patients. AJR Am J Roentgenol 186(4):995–999\nMajdalany BS et al (2017) ACR Appropriateness Criteria® chylothorax treatment planning. J Am Coll Radiol 14(5S):S118–S126\nMcDonnell MJ et al (2017) Patterns of disease in patients with middle-lobe predominant bronchiectasis. Respiration 93(6):406–414\nGrant LA, Griffin N (2019) Grainger & Allison’s diagnostic radiology essentials, 2. Aufl. Elsevier, Edinburgh\nKienzl-Palma D, Prosch H (2016) Thorakale Manifestation der Tuberkulose. Radiologe 56(10):866–873\nNachiappan AC et al (2017) Pulmonary tuberculosis: role of radiology in diagnosis and management. Radiographics 37(1):52–72\nElicker BM, Webb WR (2013) Fundamentals of high-resolution lung CT: common findings, common patterns, common diseases, and differential diagnosis. Wolters Kluwer Health, Lippincott Williams & Wilkins, Philadelphia, S 204–206\nVoegeli E (2009) Praktische Thoraxradiologie Bd. 5. Huber, Bern, S 128\nMüller-Mang C et al (2007) Idiopathic interstitial pneumonias: from classification to diagnostic work-up. Radiologe 47(5):384–392\nRaghu G et al (2018) Diagnosis of idiopathic pulmonary fibrosis. An official ATS\u002FERS\u002FJRS\u002FALAT clinical practice guideline. Am J Respir Crit Care Med 198(5):e44–e68\nBaur X, Fischer A, Budnik LT (2015) Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis). J Occup Med Toxicol 10:15\nMueller-Mang C et al (2007) What every radiologist should know about idiopathic interstitial pneumonias. Radiographics 27(3):595–615\nKatzenstein AL, Fiorelli RF (1994) Nonspecific interstitial pneumonia\u002Ffibrosis. Histologic features and clinical significance. Am J Surg Pathol 18(2):136–147\nJegal Y et al (2005) Physiology is a stronger predictor of survival than pathology in fibrotic interstitial pneumonia. Am J Respir Crit Care Med 171(6):639–644\nBaque-Juston M et al (2014) Organizing pneumonia: What is it? A conceptual approach and pictorial review. Diagn Interv Imaging 95(9):771–777\nReddy TL et al (2012) Pleuroparenchymal fibroelastosis: a spectrum of histopathological and imaging phenotypes. Eur Respir J 40(2):377–385\nGaneshan D et al (2018) Sarcoidosis from head to toe: what the radiologist needs to know. Radiographics 38(4):1180–1200\nScadding JG (1961) Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years’ observation. Br Med J 2(5261):1165–1172\nTazi A (2006) Adult pulmonary Langerhans’ cell histiocytosis. Eur Respir J 27(6):1272–1285\nSchaefer-Prokop C et al (2001) High-resolution CT of diffuse interstitial lung disease: key findings in common disorders. Eur Radiol 11(3):373–392\nCollins J (2008) Chest radiology: the essentials. 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Prosch",{"url":726,"publisher":924,"properties":964},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":925,"slug":10,"properties":926,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":930,"manageAffiliations":939,"indexDatabases":945,"url":78,"thumbnailPath":20,"statistic":959,"gsStatistic":20,"type":86,"analyzePriority":20},[],{"issn":927,"title":928,"eissn":929},{"VOID":13},{"EN":15},{"VOID":17},[931,935],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":932,"label":933,"description":934,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":936,"label":937,"description":938,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},[940],{"id":37,"createTime":20,"updateTime":20,"relativeEntities":941,"slug":20,"properties":942,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":944,"statistic":20},[],{"title":943},{"EN":41},[43],[946,952],{"id":46,"indexDatabase":947,"url":57,"indexYears":58,"academicFieldIds":20,"indexDatabaseRanking":59},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":948,"label":949,"description":950,"key":54,"publicationTags":951,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],{"id":61,"indexDatabase":953,"url":74,"indexYears":20,"academicFieldIds":958,"indexDatabaseRanking":20},{"id":63,"createTime":20,"updateTime":20,"relativeEntities":954,"label":955,"description":956,"key":70,"publicationTags":957,"standard":20},[],{"EN":66,"VI":66},{"EN":68,"VI":69},[72,73],[76,77],{"impactFactor":21,"impactFactorByYear":960,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":81,"totalPublicationByYear":961,"totalCitation":21,"totalCitationByYear":962,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":963,"hindexLast5Year":21,"hindex":21},{},{"2022":83,"2023":83},{},{},{"pages":965},{"VOID":966},"1-10","2024-01-16",[72,56],{"id":970,"createTime":971,"updateTime":972,"relativeEntities":973,"slug":974,"properties":975,"entityType":108,"verifyStatus":109,"verifyTime":972,"verifyNote":111,"languages":20,"translateLanguages":20,"viewCount":83,"primaryUrl":984,"fullTextUrl":20,"authors":985,"publicationType":209,"publisherRelationship":1014,"citationCount":20,"citationInfo":20,"publishDate":1059,"publishYear":257,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1060,"openAccess":20,"references":20,"isForceReanalyzing":260},"952d41e2-3120-4a0e-b1e9-12ecdc5062a4","2023-12-21T00:56:39.852+00:00","2025-02-21T07:39:17.825+00:00",[],"Radiologische-Abkl%C3%A4rung-pulmonaler-Rundherde",{"abstract":976,"title":978,"references":980,"doi":982},{"EN":977},"Pulmonale Rundherde sind häufig und in den meisten Fällen benigne. Um sowohl unnötige Verlaufskontrollen als auch übersehene Lungenkarzinome zu vermeiden, sollte das weitere Management risikoabhängig erfolgen. Das Malignitätsrisiko wird in erster Linie über die Größe des Rundherdes bestimmt, aber auch weitere radiologische und nichtradiologische Kriterien können bei der Dignitätsabschätzung hilfreich sein. Empfehlungen für die Verlaufskontrolle inzidenteller Rundherde gab die Fleischner-Gesellschaft heraus. Für Patienten mit bekanntem Malignom oder Immunsuppression oder im Rahmen eines Früherkennungsprogramms gelten diese Kriterien aufgrund des unterschiedlichen Risikos nicht. In diesem Artikel werden die Malignitätskriterien pulmonaler Rundherde erläutert, die Empfehlungen der Fleischner-Gesellschaft vorgestellt und ein kurzer Ausblick auf ein mögliches Lungenkarzinomscreening in Deutschland gegeben. Ziel ist es, eine praktische Anleitung für die radiologische Abklärung pulmonaler Rundherde zu geben.",{"EN":979},"Radiologische Abklärung pulmonaler Rundherde",{"VOID":981},"Wormanns D, Hamer O (2015) Glossar thoraxradiologischer Begriffe entsprechend der Terminologie der Fleischner Society. Rofo 187:638–661. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0035-1553216\nHe Y‑T, Zhang Y‑C, Shi G‑F et al (2018) Risk factors for pulmonary nodules in north China: a prospective cohort study. Cancer Treat Res 120:122–129. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.lungcan.2018.03.021\nMarrer É, Jolly D, Arveux P et al (2017) Incidence of solitary pulmonary nodules in Northeastern France: a population-based study in five regions. BMC Cancer 17:47. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12885-016-3029-z\nHammerschlag G, Cao J, Gumm K et al (2015) Prevalence of incidental pulmonary nodules on computed tomography of the thorax in trauma patients. Intern Med J 45:630–633. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fimj.12755\nIñiguez CB, Kwon N, Jacobson F et al (2018) Estimating incidence of solitary pulmonary nodules: novel methods using claims data to answer unknown epidemiological questions. Chest 154:661A. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.chest.2018.08.597\nMcWilliams A, Tammemagi MC, Mayo JR et al (2013) Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med 369:910–919. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1214726\nErdmann F, Spix C, Katalinic A et al (2021) Krebs in Deutschland für 2017\u002F2018 https:\u002F\u002Fdoi.org\u002F10.25646\u002F8353\nHasegawa M, Sone S, Takashima S et al (2000) Growth rate of small lung cancers detected on mass CT screening. Br J Radiol 73:1252–1259. https:\u002F\u002Fdoi.org\u002F10.1259\u002Fbjr.73.876.11205667\nYankelevitz DF, Yip R, Smith JP et al (2015) CT screening for lung cancer: nonsolid nodules in baseline and annual repeat rounds. Radiology 277:555–564. https:\u002F\u002Fdoi.org\u002F10.1148\u002Fradiol.2015142554\nWoodring J, Fried A (1983) Significance of wall thickness in solitary cavities of the lung: a follow-up study. AJR Am J Roentgenol 140:473–474. https:\u002F\u002Fdoi.org\u002F10.2214\u002Fajr.140.3.473\nKwak N, Park C‑M, Lee J et al (2014) Lung cancer risk among patients with combined pulmonary fibrosis and emphysema. Respir Med 108:524–530. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.rmed.2013.11.013\nAther S, Kadir T, Gleeson F (2020) Artificial intelligence and radiomics in pulmonary nodule management: current status and future applications. Clin Radiol 75:13–19. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.crad.2019.04.017\nÖberg M, Jaakkola MS, Woodward A et al (2011) Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries. Lancet 377:139–146. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(10)61388-8\nSiegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68:7–30. https:\u002F\u002Fdoi.org\u002F10.3322\u002Fcaac.21442\nHaiman CA, Stram DO, Wilkens LR et al (2006) Ethnic and racial differences in the smoking-related risk of lung cancer. N Engl J Med 354:333–342. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa033250\nLee PN (2001) Relation between exposure to asbestos and smoking jointly and the risk of lung cancer. Occup Environ Med 58:145–153. https:\u002F\u002Fdoi.org\u002F10.1136\u002Foem.58.3.145\nField RW, Steck DJ, Smith BJ et al (2000) Residential radon gas exposure and lung cancer: the iowa radon lung cancer study. Am J Epidemiol 151:1091–1102. https:\u002F\u002Fdoi.org\u002F10.1093\u002Foxfordjournals.aje.a010153\nGottlieb LS, Husen LA (1982) Lung cancer among navajo uranium miners. Chest 81:449–452. https:\u002F\u002Fdoi.org\u002F10.1378\u002Fchest.81.4.449\nGonzález Maldonado S, Delorme S, Hüsing A et al (2020) Evaluation of prediction models for identifying malignancy in pulmonary nodules detected via low-dose computed tomography. JAMA Netw Open 3:e1921221. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjamanetworkopen.2019.21221\nUpToDate Calculator: solitary pulmonary nodule malignancy risk in adults (Brock University cancer prediction equation). https:\u002F\u002Fwww.uptodate.com\u002Fcontents\u002Fcalculator-solitary-pulmonary-nodule-malignancy-risk-in-adults-brock-university-cancer-prediction-equation?search=lung_cancer_diagnosis&topicRef=4632&source=see_link%0A. Zugegriffen: 1. März 2022\nGould MK, Donington J, Lynch WR et al (2013) Evaluation of individuals with pulmonary nodules: when is it lung cancer? Chest 143:e93S–e120S. https:\u002F\u002Fdoi.org\u002F10.1378\u002Fchest.12-2351\nYau G, Lock M, Rodrigues G (2007) Systematic review of baseline low-dose CT lung cancer screening. Cancer Treat Res 58:161–170. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.lungcan.2007.07.006\nMacMahon H, Naidich DP, Goo JM et al (2017) Guidelines for management of incidental pulmonary nodules detected on CT images: from the Fleischner society 2017. Radiology 284:228–243. https:\u002F\u002Fdoi.org\u002F10.1148\u002Fradiol.2017161659\nHein P, Romano V, Rogalla P et al (2009) Linear and volume measurements of pulmonary nodules at different CT dose levels—intrascan and Interscan analysis. Rofo 181:24–31. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-2008-1027874\nThe National Lung Screening Trial Research Team (2011) Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365:395–409. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1102873\nde Koning HJ, van der Aalst CM, de Jong PA et al (2020) Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med 382:503–513. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMoa1911793\nBecker N, Motsch E, Trotter A et al (2020) Lung cancer mortality reduction by LDCT screening—results from the randomized German LUSI trial. Int J Cancer 146:1503–1513. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fijc.32486\nLeitlinienprogramm Onkologie (2018) Prävention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms, Langversion 1.0 (AWMF-Registernummer: 020\u002F007OL)\nBundesamt für Strahlenschutz (BfS) (2021) Lungenkrebsfrüherkennung mittels Niedrigdosis-Computertomographie – Wissenschaftliche Bewertung des Bundesamtes für Strahlenschutz gemäß § 84 Absatz 3 Strahlenschutzgesetz. http:\u002F\u002Fdoris.bfs.de\u002Fjspui\u002Fbitstream\u002Furn:nbn:de:0221-2021082028027\u002F3\u002FLungenkrebsfrueherkennung-mittels-Niedrigdosis-Computertomographie.pdf. Zugegriffen: 7. Apr. 2022\nInstitut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) (2020) Lungenkrebsscreening mittels Computertomografie Impressum. https:\u002F\u002Fwww.iqwig.de\u002Fdownload\u002Fs19-02_lungenkrebsscreening-mittels-low-dose-ct_abschlussbericht_v1-0.pdf. Zugegriffen: 7. Apr. 2022\nDeutsches Zentrum für Lungenforschung Hanse Lungencheck. https:\u002F\u002Fwww.hanse-lungencheck.de\u002F. Zugegriffen: 7. Apr. 2022\nDeutsches Krebsforschungszentrum (DKFZ) Studie 4‑IN-THE-LUNG-RUN. https:\u002F\u002Fwww.dkfz.de\u002Fde\u002Fepidemiologie-krebserkrankungen\u002Farbeitsgr\u002FLungenkrebsscreening\u002F4-IN-THE-LUNG-Run-Ziele.html. Zugegriffen: 7. Apr. 2022\nAmerican College of Radiology Committee on Lung-RADS® (2019) Lung-RADS assessment categories version1.1. https:\u002F\u002Fwww.acr.org\u002F-\u002Fmedia\u002FACR\u002FFiles\u002FRADS\u002FLung-RADS\u002FLungRADSAssessmentCategoriesv1-1.pdf;. Zugegriffen: 11. Febr. 2022",{"VOID":983},"10.1007\u002Fs10405-022-00454-0","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10405-022-00454-0",[986,1001],{"id":987,"sortIndex":21,"researcher":20,"roles":988,"affiliations":989,"properties":998},"cfc8b5ed-dd6f-478d-b271-afee491422e0",[117],[990],{"id":991,"sortIndex":21,"affiliation":992,"properties":20},"a7672c98-63c3-489e-90b2-ab8362a6f459",{"id":991,"createTime":20,"updateTime":20,"relativeEntities":993,"slug":20,"properties":994,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":997,"statistic":20},[],{"title":995},{"VI":996},"Institut für Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Hannover, Deutschland",[],{"title":999},{"VI":1000},"Julian Glandorf",{"id":1002,"sortIndex":83,"researcher":20,"roles":1003,"affiliations":1004,"properties":1011},"c98c738e-1cdf-46d8-a8b8-28b5f784735f",[117],[1005],{"id":991,"sortIndex":21,"affiliation":1006,"properties":20},{"id":991,"createTime":20,"updateTime":20,"relativeEntities":1007,"slug":20,"properties":1008,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1010,"statistic":20},[],{"title":1009},{"VI":996},[],{"title":1012},{"VI":1013},"Sabine Dettmer",{"url":984,"publisher":1015,"properties":1055},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1016,"slug":10,"properties":1017,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1021,"manageAffiliations":1030,"indexDatabases":1036,"url":78,"thumbnailPath":20,"statistic":1050,"gsStatistic":20,"type":86,"analyzePriority":20},[],{"issn":1018,"title":1019,"eissn":1020},{"VOID":13},{"EN":15},{"VOID":17},[1022,1026],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1023,"label":1024,"description":1025,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":1027,"label":1028,"description":1029,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},[1031],{"id":37,"createTime":20,"updateTime":20,"relativeEntities":1032,"slug":20,"properties":1033,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1035,"statistic":20},[],{"title":1034},{"EN":41},[43],[1037,1043],{"id":46,"indexDatabase":1038,"url":57,"indexYears":58,"academicFieldIds":20,"indexDatabaseRanking":59},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1039,"label":1040,"description":1041,"key":54,"publicationTags":1042,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],{"id":61,"indexDatabase":1044,"url":74,"indexYears":20,"academicFieldIds":1049,"indexDatabaseRanking":20},{"id":63,"createTime":20,"updateTime":20,"relativeEntities":1045,"label":1046,"description":1047,"key":70,"publicationTags":1048,"standard":20},[],{"EN":66,"VI":66},{"EN":68,"VI":69},[72,73],[76,77],{"impactFactor":21,"impactFactorByYear":1051,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":81,"totalPublicationByYear":1052,"totalCitation":21,"totalCitationByYear":1053,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1054,"hindexLast5Year":21,"hindex":21},{},{"2022":83,"2023":83},{},{},{"pages":1056,"volume":1058},{"VOID":1057},"318-328",{"VOID":255},"2022-07-04",[72,56],{"id":1062,"createTime":1063,"updateTime":1064,"relativeEntities":1065,"slug":1066,"properties":1067,"entityType":108,"verifyStatus":109,"verifyTime":1064,"verifyNote":111,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1076,"fullTextUrl":20,"authors":1077,"publicationType":209,"publisherRelationship":1115,"citationCount":20,"citationInfo":20,"publishDate":1160,"publishYear":257,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1161,"openAccess":20,"references":20,"isForceReanalyzing":260},"6712e0aa-a73a-44d2-b191-5c4050aa2481","2023-12-07T08:47:26.646+00:00","2025-02-20T20:24:37.669+00:00",[],"Antibiotic-Stewardship-und-Pneumonie",{"abstract":1068,"title":1070,"references":1072,"doi":1074},{"EN":1069},"Die Pneumonie ist eine sehr häufige und potenziell tödliche Erkrankung. Es werden 3 Entitäten (ambulant erworbenen = CAP, nosokomial erworben = HAP und Pneumonie unter Immunsuppression) unterschieden von denen insbesondere die CAP und die HAP für die Umsetzung von Antibiotic Stewardship(ABS)-Strategien, den rationalen Umgang mit Antibiotika, gut geeignet sind. Die Durchführung einer mikrobiologischen Diagnostik vor Start einer Antibiotikatherapie bei Pneumonie, die stationär behandelt werden muss, wird stark empfohlen. Eine Risikostratifizierung der Patienten und der Schweregrad der Erkrankung sind entscheidend für die kalkulierte Antibiotikaauswahl und die Applikationsform. Bei COVID-19-Patienten ohne septischen Schock kann aufgrund der niedrigen Rate von bakteriellen Superinfektionen auf eine empirische Antibiotikatherapie verzichtet werden. Eine Reevaluation der Antibiotikatherapie nach 48–72 h mit gezielter Deeskalation unter Beachtung der Klinik und Mikrobiologie, Absetzen bei Fehlindikation und die Begrenzung der Therapiedauer sind essenzielle ABS-Strategien zur Optimierung des klinischen Outcomes bei CAP und HAP mit dem Ziel, die Antibiotikaresistenzentwicklung sowie die Toxizität für den Patienten möglichst gering zu halten. Der Einsatz von Biomarkern wie Procalcitonin kann in bestimmten Situationen ein frühzeitiges Absetzen der Therapie begünstigen oder die Diagnose einer bakteriellen Superinfektion bei COVID-19 unterstützen.",{"EN":1071},"Antibiotic Stewardship und Pneumonie",{"VOID":1073},"Antimicrobial Resistance Collaborators (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399(10325):629–655\nArnold FW, LaJoie AS, Brock GN et al (2009) Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: community-acquired pneumonia organization international cohort study results. Arch Intern Med 169(16):1515–1524\nBouglé A, Tuffet S, Federici L et al (2022) Comparison of 8 versus 15 days of antibiotic therapy for pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Intensive Care Med 48(7):841–849\nBurkhardt O, Ewig S, Haagen U et al (2010) Procalcitonin guidance and reduction of antibiotic use in acute respiratory tract infection. Eur Respir J 36:601–607\nDalhoff K, Abele-Horn M, Andreas S et al (2018) Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia—Update 2017—S3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy, the German Radiological Society and the Society for Virology]. Pneumologie 72(1):15–63\nDe With K, Wilke K, Kern WV, et al. (2019) S3 Leitlinie Strategien zur Sicherung rationaler Antibiotikaanwendung im Krankenhaus. AWMF-Registernummer 092\u002F001—update 2018. (Stand 31.01.2019, gültig bis 30. Jan. 2024)\nEbell MH, Chupp H, Cai X et al (2020) Accuracy of signs and symptoms for the diagnosis of community-acquired pneumonia: a meta-analysis. Acad Emerg Med 27(7):541–567\nEwig S, Kolditz M, Pletz M et al (2021) Management of Adult Community-Acquired Pneumonia and Prevention—Update 2021—Guideline of the German Respiratory Society (DGP), the Paul-Ehrlich-Society for Chemotherapy (PEG), the German Society for Infectious Diseases (DGI), the German Society of Medical Intensive Care and Emergency Medicine (DGIIN), the German Viological Society (DGV), the Competence Network CAPNETZ, the German College of General Practitioneers and Family Physicians (DEGAM), the German Society for Geriatric Medicine (DGG), the German Palliative Society (DGP), the Austrian Society of Pneumology Society (ÖGP), the Austrian Society for Infectious and Tropical Diseases (ÖGIT), the Swiss Respiratory Society (SGP) and the Swiss Society for Infectious Diseases Society (SSI)]. Pneumologie 75(9):665–729\nKolditz M, Tesch F, Mocke L et al (2016) Burden and risk factors of ambulatory or hospitalized CAP: a population based cohort study. Respir Med 121:32–38\nMakhnevich A, Sinvani L, Cohen SL et al (2019) The clinical utility of chest radiography for identifying pneumonia: accounting for diagnostic uncertainty in radiology reports. Cardiopulm Imaging 213(6):1207–1212\nMoeser A, Lange C, von Lilienfeld-Toal M et al (2018) Pneumonia in immunocompromised patients. Pneumologe 15(3):209–224\nPaul M, Carrara E, Retamar P et al (2022) European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine). Clin Microbiol Infect 28(4):521–547\nSchouten J, De Waele J, Lanckohr C et al (2021) Antimicrobial stewardship in the ICU in COVID-19 times: the known unknowns. Int J Antimicrob Agents 58(4):106409\nSchweitzer VA, van Heijl I, Boersma WG et al (2021) Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial. Lancet Infect Dis 22(2):274–283\nKang SHYHJJHL et al (2021) Antibiotic prescription consistent with guidelines in emergency department is associated with 30-day survival in severe community-acquired pneumonia. BMC Emerg Med 21(1):108\nSingh N, Rogers P, Atwood CW et al (2000) Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. 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Pneumologie 72(5):341–346\nVan Vugt SF, Broekhuizenj BDL, Lammens C et al (2013) Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ 346:f2450\nUranga A, España PP, Bilbao A et al (2016) Duration of antibiotic treatment in community-acquired pneumonia. A multicenter randomized clinical trial. 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Schnittstellenprobleme in der derzeitigen Versorgung führen, verstärkt durch die Pandemie, zu Fehlversorgungen und langen Wartezeiten bei Diagnostik und Therapie. Auf Basis bestehender Strukturen soll ein sektorenübergreifendes Versorgungsmodell für die Diagnostik und Therapie bei OSA evaluiert werden. Zentrale Ziele sind eine zeitnahe, bedarfsgerechte Versorgung mit optimierter Qualität und Effizienz. Ferner sollen die Therapietreue und damit die Lebensqualität verbessert werden, ebenso die sektorenübergreifende Zusammenarbeit. Das Projekt SLEEP WELL wird durch den Innovationsfonds des G-BA gefördert (Förderkennzeichen 01NVF20020). Die Evaluation erfolgt auf Basis einer prospektiven, randomisierten, kontrollierten, multizentrischen Studie in Nordrhein-Westfalen, in der 4448 Patientinnen mit Verdacht auf OSA mit (Telemedizingruppe) bzw. ohne Telemedizin (Kontrollgruppe) leitlinienkonform versorgt werden. Die 1:1-Randomisierung erfolgt nach initialer Verdachtsstellung durch die Primärärztin. Die beiden Gruppen werden hinsichtlich Lebensqualität (primärer Endpunkt), PAP-Therapie-Adhärenz und medizinischem Ressourcenverbrauch (sekundäre Zielgrößen) verglichen. Quantitative Datenerhebungen erfolgen zu 5 Zeitpunkten. In einer ITT-Analyse („intention to treat analysis“) werden die Ergebnisse statistisch ausgewertet. Die Zufriedenheit der Patientinnen und Leistungserbringer wird mittels qualitativer Methoden erhoben. Auf Basis der Krankenkassenroutinedaten wird die Kosten-Nutzen-Relation untersucht. Zudem werden Vergütungskonzepte für die Regelversorgung erarbeitet. Projektabschluss ist für 09\u002F2025 geplant.",{"EN":1172},"SLEEP WELL",{"VOID":1174},"Lévy P et al (2015) Obstructive sleep apnoea syndrome. Nat Rev Dis Primers 1:15015\nJavaheri S et al (2017) Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. J Am Coll Cardiol 69:841–858\nMorsy NE et al (2019) Obstructive sleep apnea: personal, societal, public health, and legal implications. Rev Environ Health 34:153–169\nWickwire EM et al (2020) Older adult US Medicare beneficiaries with untreated obstructive sleep apnea are heavier users of health care than controls. J Clin Sleep Med 16:81–89\nBenjafield AV et al (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7:687–698\nMayer G et al (2017) S3-Leitlinie Nicht erholsamer Schlaf \u002F Schlafstörungen, Kapitel Schlafbezogene Atmungsstörungen bei Erwachsenen. Somnologie 20(Suppl s2):S97–S180\nPatil SP et al (2019) Treatment of adult sleep apnea with positive airway pressure: an American Academy of Sleep Medicine systematic review, meta-analysis and GRADE assessment. J Clin Sleep Med 15:301–334\nWoehrle H et al (2018) Predictors of positive airway pressure therapy termination in the first year: analysis of big data from a German homecare provider. BMC Pulm Med 18:186\nG‑BA (2019) Richtlinie des G‑BA zu Untersuchungs- und Behandlungsmethoden der vertragsärztlichen Versorgung. https:\u002F\u002Fwww.g-ba.de\u002Fdownloads\u002F62-492-2063\u002FMVV-RL-2019-12-19-iK-2020-03-12.pdf. Zugegriffen: 22. März 2020\nJacobsen AR et al (2017) Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea. PLoS ONE 12:e189614\nBudhiraja R et al (2007) Early CPAP use identifies subsequent adherence to CPAP therapy. Sleep 30:320–324\nWoehrle H et al (2017) Telemedicine-based proactive patient management during positive airway pressure therapy: Impact on therapy termination rate. Somnologie 21:121–127\nNilius G et al (2019) Telemedicine improves continuous positive airway pressure adherence in stroke patients with obstructive sleep apnea in a randomized trial. Respiration 98:410–420\nChiu HY et al (2017) Diagnostic accuracy of the BQ, STOP-BANG, STOP and Epworth sleepiness scale in detecting OSA: a bivariate meta-analysis. Sleep Med Rev 36:57–70\nNagappa M et al (2015) Validation of the STOP-bang questionnaire as a screening tool for obstructive sleep apnea among different populations: a systematic review and meta-analysis. PLoS ONE 10:e143697\nBayerische Krankenhausgesellschaft (2019) Vereinbarung nach §115a Absatz 3 Satz1 und Satz2 SGBV über die Behandlung schlafbezogener Atmungsstörungen bei Erwachsenen. https:\u002F\u002Fwww.bkg-online.de\u002Fmedia\u002Fmediapool_BKG\u002F02_infos-services\u002FDownloads\u002FVerzeichnis_der_Landesvertraege\u002FVereinbarung_unterschrieben.pdf. Zugegriffen: 2. 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