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Emulgel dressings were prepared by dispersing positively charged submicron vesicles in carboxymethyl cellulose gel. Release kinetics of \u003Cjats:styled-content style=\"fixed-case\">SFN\u003C\u002Fjats:styled-content>\u002F\u003Cjats:styled-content style=\"fixed-case\">ASA\u003C\u002Fjats:styled-content> and toxicity for primary skin cells were assessed in vitro. Antifibrogenic efficacy of medicated emulgel dressings was tested on a rabbit ear fibrotic model. Following topical application on the wounds, emulgels formed an occlusive film and controlled the release of \u003Cjats:styled-content style=\"fixed-case\">SFN\u003C\u002Fjats:styled-content> and \u003Cjats:styled-content style=\"fixed-case\">ASA\u003C\u002Fjats:styled-content> for 7 and 24 hours, respectively. Wounds treated with \u003Cjats:styled-content style=\"fixed-case\">SFN\u003C\u002Fjats:styled-content>\u002F\u003Cjats:styled-content style=\"fixed-case\">ASA\u003C\u002Fjats:styled-content>‐containing emulgel dressings showed an 80% reduction in scar elevation compared with untreated controls. Topical formulations were nontoxic for cultured human keratinocytes and fibroblasts. Inflammation was significantly controlled in treated wounds, as shown by a reduced number of infiltrated \u003Cjats:styled-content style=\"fixed-case\">CD3\u003C\u002Fjats:styled-content>\u003Cjats:sup>+\u003C\u002Fjats:sup> \u003Cjats:styled-content style=\"fixed-case\">T\u003C\u002Fjats:styled-content> cells (\u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.001) and macrophages. \u003Cjats:styled-content style=\"fixed-case\">SFN\u003C\u002Fjats:styled-content>\u002F\u003Cjats:styled-content style=\"fixed-case\">ASA\u003C\u002Fjats:styled-content>‐treated wounds showed a significantly higher (\u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.001) expression of matrix metalloproteinase‐1, resulting in reduced collagen deposition and less scarring. Film‐forming emulgel dressings that control the release of antifibrogenic and anti‐inflammatory factors provide an excellent treatment option for postburn hypertrophic scar management.\u003C\u002Fjats:p>",{"EN":114},"Topical application of a film‐forming emulgel dressing that controls the release of stratifin and acetylsalicylic acid and improves\u002Fprevents hypertrophic scarring",{"VOID":116},"23126516",{"VOID":118},"10.1111\u002Fj.1524-475x.2012.00857.x","PUBLICATION","VERIFIED","Auto Verify",[123],"EN","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1524-475X.2012.00857.x",[126,143,161,177,195,211],{"id":127,"sortIndex":25,"researcher":24,"roles":128,"affiliations":129,"properties":138,"displayName":140,"givenName":24,"familyName":24},"bbc8c324-81c8-40a2-b948-59fdd7de92bd",[],[130],{"id":131,"sortIndex":25,"affiliation":132,"properties":24},"9bf681ea-1cfa-4c91-b46a-17dcf0c1b516",{"id":131,"createTime":24,"updateTime":24,"relativeEntities":133,"slug":24,"properties":134,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":137,"statistic":24},[],{"title":135},{"VI":136},"Department of Surgery\u002FDivision of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada",[],{"title":139,"openalex":141},{"EN":140},"Elham Rahmani‐Neishaboor",{"VOID":142},"A5056688281",{"id":144,"sortIndex":145,"researcher":24,"roles":146,"affiliations":147,"properties":156,"displayName":158,"givenName":24,"familyName":24},"52e99b97-762e-4b99-af46-3dad59848469",1,[],[148],{"id":149,"sortIndex":25,"affiliation":150,"properties":24},"557c5028-77e3-4b08-8b0f-99b4c2f6178f",{"id":149,"createTime":24,"updateTime":24,"relativeEntities":151,"slug":24,"properties":152,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":155,"statistic":24},[],{"title":153},{"EN":154},"University of British Columbia Department of Surgery Division of Plastic Surgery Vancouver BC Canada",[],{"title":157,"openalex":159},{"EN":158},"Reza Jallili",{"VOID":160},"A5089199394",{"id":162,"sortIndex":163,"researcher":24,"roles":164,"affiliations":165,"properties":172,"displayName":174,"givenName":24,"familyName":24},"174554ac-6a55-4f21-9ae7-cf6b1ff8011f",2,[],[166],{"id":149,"sortIndex":25,"affiliation":167,"properties":24},{"id":149,"createTime":24,"updateTime":24,"relativeEntities":168,"slug":24,"properties":169,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":171,"statistic":24},[],{"title":170},{"EN":154},[],{"title":173,"openalex":175},{"EN":174},"Ryan Hartwell",{"VOID":176},"A5064579544",{"id":178,"sortIndex":179,"researcher":24,"roles":180,"affiliations":181,"properties":188,"displayName":192,"givenName":24,"familyName":24},"dc1d8aee-5c7d-42f6-ac1e-e80c39034633",3,[],[182],{"id":149,"sortIndex":25,"affiliation":183,"properties":24},{"id":149,"createTime":24,"updateTime":24,"relativeEntities":184,"slug":24,"properties":185,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":187,"statistic":24},[],{"title":186},{"EN":154},[],{"orcid":189,"title":191,"openalex":193},{"VOID":190},"https:\u002F\u002Forcid.org\u002F0000-0003-3529-2640",{"EN":192},"Victor C. 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US Pharmacopeia.2001.",{},{"id":24,"text":385,"url":24,"identifiers":386},"10.1016\u002Fj.bjps.2008.03.022",{"doi":385},{"id":24,"text":388,"url":24,"identifiers":389},"10.1111\u002Fj.1067-1927.2004.0abstractxp.x",{"doi":388},{"id":24,"text":391,"url":24,"identifiers":392},"10.1111\u002Fj.1524-475X.2008.00404.x",{"doi":391},{"id":24,"text":394,"url":24,"identifiers":395},"Escobar‐Chavez JJ, 2006, Applications of thermo‐reversible pluronic F‐127 gels in pharmaceutical formulations, J Pharm Pharm Sci, 9, 339",{},{"id":24,"text":397,"url":24,"identifiers":398},"10.12968\u002Fjowc.2003.12.4.26484",{"doi":397},{"id":24,"text":400,"url":24,"identifiers":401},"10.1111\u002Fj.0022-202X.2004.23521.x",{"doi":400},{"id":24,"text":403,"url":24,"identifiers":404},"10.1111\u002Fj.1524-475X.2007.00224.x",{"doi":403},{"id":24,"text":406,"url":24,"identifiers":407},"10.1016\u002FS0305-4179(97)00070-3",{"doi":406},false,{"id":410,"createTime":411,"updateTime":412,"relativeEntities":413,"slug":414,"properties":415,"entityType":119,"verifyStatus":120,"verifyTime":411,"verifyNote":121,"languages":432,"translateLanguages":433,"viewCount":25,"primaryUrl":435,"fullTextUrl":24,"authors":436,"publicationType":229,"publisherRelationship":516,"citationCount":565,"citationInfo":566,"publishDate":576,"publishYear":567,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":577,"openAccess":24,"references":578,"isForceReanalyzing":408},"5f2405cd-a627-421d-88f2-ce040e56f4ad","2024-10-16T00:28:46.666+00:00","2025-02-22T21:33:42.990+00:00",[],"Mast-cells-modulate-the-inflammatory-but-not-the-proliferative-response-in-healing-wounds",{"mag":416,"keywords":418,"openalex":420,"abstract":422,"title":425,"pm":428,"doi":430},{"VOID":417},"2062712176",{"VI":419},"",{"VOID":421},"W2062712176",{"EN":423,"VI":424},"\u003Cjats:p>Upon stimulation, mast cells release a heterogeneous group of factors that promote inflammation and influence cell proliferation. Mast cells accumulate at sites of injury, further suggesting a critical role in wound healing. To assess the importance of mast cells in tissue repair, we compared wound healing in mast cell–deficient WBB6F1\u002FJ‐Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> (Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup>) and wild type WBB6F1\u002F++ (WT) mice. During the inflammatory phase, neutrophil infiltration into wounds of the Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> mice was significantly less than that of WT mice (84.6 ± 10.3 vs. 218 ± 26.0 cells\u002F10 high‐power fields at day 3, \u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.001), while wound macrophage and T cell infiltration were similar in both strains. The decrease in neutrophils could not be explained by changes in tumor necrosis factor‐α or macrophage inflammatory protein‐2 levels, because the amounts of these two neutrophil chemoattractants were similar in both Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> and WT mice. Surprisingly, the absence of mast cells had no effect on the proliferative aspects of wound healing, including reepithelialization, collagen synthesis, and angiogenesis. Although mast cells are known to release proangiogenic mediators, vascular endothelial growth factor levels were similar in WT and Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> mice. Moreover, levels of fibroblast growth factor‐2 were increased in Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> mice (4206 ± 107 vs. 1865 ± 249 pg\u002Fml, \u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.01). These results suggest that mast cells modulate the recruitment of neutrophils into sites of injury, yet indicate that mast cells are unlikely to exert a major influence on the proliferative response within healing wounds. \u003Cjats:bold>(WOUND REP REG 2003;11:46–54)\u003C\u002Fjats:bold>\u003C\u002Fjats:p>","\u003Cjats:p>B upon kích thích, tế bào mast giải phóng một nhóm các yếu tố đa dạng thúc đẩy viêm và ảnh hưởng đến sự phát triển của tế bào. Tế bào mast tích tụ tại các vị trí tổn thương, điều này càng gợi ý một vai trò quan trọng trong quá trình lành vết thương. Để đánh giá tầm quan trọng của tế bào mast trong việc sửa chữa mô, chúng tôi đã so sánh quá trình lành vết thương ở chuột thiếu tế bào mast WBB6F1\u002FJ‐Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> (Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup>) và chuột kiểu hoang dã WBB6F1\u002F++ (WT). Trong giai đoạn viêm, sự thâm nhập của bạch cầu trung tính vào các vết thương của chuột Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> ít đáng kể hơn so với chuột WT (84.6 ± 10.3 so với 218 ± 26.0 tế bào\u002F10 trường nổi bật vào ngày thứ 3, \u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.001), trong khi sự thâm nhập của đại thực bào và tế bào T là tương tự ở cả hai dòng. Việc giảm bạch cầu trung tính không thể giải thích bằng việc thay đổi mức độ yếu tố hoại tử khối u‐α hoặc protein viêm mạch đại thực bào‐2, vì lượng của hai yếu tố chemoattractant này là tương tự ở cả chuột Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> và WT. Ngạc nhiên thay, sự vắng mặt của tế bào mast không có ảnh hưởng đến các khía cạnh phát triển trong quá trình lành vết thương, bao gồm tái biểu mô, tổng hợp collagen và tạo mạch. Mặc dù tế bào mast được biết đến với việc giải phóng các chất trung gian proangiogenic, mức độ yếu tố tăng trưởng nội mô mạch máu tương tự ở chuột WT và Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup>. Hơn nữa, mức độ yếu tố tăng trưởng fibroblast‐2 được tăng lên ở chuột Kit\u003Cjats:sup>W\u003C\u002Fjats:sup>\u002FKit\u003Cjats:sup>W–v\u003C\u002Fjats:sup> (4206 ± 107 so với 1865 ± 249 pg\u002Fml, \u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.01). Những kết quả này cho thấy rằng tế bào mast điều chỉnh sự tuyển dụng bạch cầu trung tính vào các vị trí tổn thương, tuy nhiên cho thấy rằng tế bào mast khó có thể có ảnh hưởng lớn đến phản ứng tăng sinh trong các vết thương đang lành. \u003Cjats:bold>(WOUND REP REG 2003;11:46–54)\u003C\u002Fjats:bold>\u003C\u002Fjats:p>",{"EN":426,"VI":427},"Mast cells modulate the inflammatory but not the proliferative response in healing wounds","Tế bào mast điều chỉnh phản ứng viêm nhưng không phải phản ứng tăng sinh trong quá trình lành vết thương",{"VOID":429},"12581426",{"VOID":431},"10.1046\u002Fj.1524-475x.2003.11108.x",[123],[434],"VI","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1524-475X.2003.11108.x",[437,454,469,484,499],{"id":438,"sortIndex":25,"researcher":24,"roles":439,"affiliations":440,"properties":449,"displayName":451,"givenName":24,"familyName":24},"ba62bb46-cc23-42b4-a909-a6a286ebf2b6",[],[441],{"id":442,"sortIndex":25,"affiliation":443,"properties":24},"4dd8be07-d27c-4ffe-b146-619bcd7a1aba",{"id":442,"createTime":24,"updateTime":24,"relativeEntities":444,"slug":24,"properties":445,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":448,"statistic":24},[],{"title":446},{"EN":447},"From the Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center, Maywood, Illinois.",[],{"title":450,"openalex":452},{"EN":451},"Eric I. Egozi",{"VOID":453},"A5088387463",{"id":455,"sortIndex":145,"researcher":24,"roles":456,"affiliations":457,"properties":464,"displayName":466,"givenName":24,"familyName":24},"4893b1e5-3607-4f26-b218-8f9de3c29460",[],[458],{"id":442,"sortIndex":25,"affiliation":459,"properties":24},{"id":442,"createTime":24,"updateTime":24,"relativeEntities":460,"slug":24,"properties":461,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":463,"statistic":24},[],{"title":462},{"EN":447},[],{"title":465,"openalex":467},{"EN":466},"Ahalia M. 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Hematologic and ultrastructural observations, Am J Pathol, 65, 79",{},{"id":24,"text":626,"url":24,"identifiers":627},"Leibovich SJ, 1975, The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum, Am J Pathol, 78, 71",{},{"id":24,"text":629,"url":24,"identifiers":630},"10.1097\u002F00024382-199510000-00001",{"doi":629},{"id":24,"text":632,"url":24,"identifiers":633},"10.1016\u002FS0030-6665(20)30469-2",{"doi":632},{"id":24,"text":635,"url":24,"identifiers":636},"10.1046\u002Fj.1365-2168.1998.00734.x",{"doi":635},{"id":24,"text":638,"url":24,"identifiers":639},"10.1111\u002Fj.1600-0625.1999.tb00342.x",{"doi":638},{"id":24,"text":641,"url":24,"identifiers":642},"10.1080\u002F08941930290085903",{"doi":641},{"id":24,"text":644,"url":24,"identifiers":645},"Marks RM, 1986, Mast cell granules cause proliferation of human microvascular endothelial cells, Lab Invest, 55, 289",{},{"id":24,"text":647,"url":24,"identifiers":648},"Norrby K, 1997, Mast cells and de novo angiogenesis: angiogenic capability of individual mast‐cell mediators such as histamine, TNF, IL‐8 and bFGF, Inflamm Res, 46, S7, 10.1007\u002FPL00022372",{"doi":649},"10.1007\u002FPL00022372",{"id":24,"text":651,"url":24,"identifiers":652},"Meininger CJ, 1992, Mast cells and angiogenesis, Semin Cancer Biol, 3, 73",{},{"id":24,"text":654,"url":24,"identifiers":655},"10.1002\u002Fijc.2910180520",{"doi":654},{"id":24,"text":657,"url":24,"identifiers":658},"10.1182\u002Fblood.V86.7.2488.2488",{"doi":657},{"id":24,"text":660,"url":24,"identifiers":661},"Reed JA, 1995, Human cutaneous mast cells express basic fibroblast growth factor, Lab Invest, 72, 215",{},{"id":24,"text":663,"url":24,"identifiers":664},"Qu Z, 1995, Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma, Am J Pathol, 147, 564",{},{"id":24,"text":666,"url":24,"identifiers":667},"10.1091\u002Fmbc.9.4.875",{"doi":666},{"id":24,"text":669,"url":24,"identifiers":670},"10.1007\u002Fs004180050328",{"doi":669},{"id":24,"text":672,"url":24,"identifiers":673},"10.1084\u002Fjem.188.6.1135",{"doi":672},{"id":24,"text":675,"url":24,"identifiers":676},"10.1084\u002Fjem.176.5.1375",{"doi":675},{"id":24,"text":678,"url":24,"identifiers":679},"10.1016\u002FS0039-6060(96)80148-6",{"doi":678},{"id":24,"text":681,"url":24,"identifiers":682},"Nissen NN, 1998, Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing, Am J Pathol, 152, 1445",{},{"id":24,"text":684,"url":24,"identifiers":685},"10.1073\u002Fpnas.95.10.5672",{"doi":684},{"id":24,"text":687,"url":24,"identifiers":688},"10.1084\u002Fjem.152.4.931",{"doi":687},{"id":24,"text":690,"url":24,"identifiers":691},"10.1172\u002FJCI119458",{"doi":690},{"id":24,"text":693,"url":24,"identifiers":694},"10.1016\u002FS0014-2999(00)00350-2",{"doi":693},{"id":24,"text":696,"url":24,"identifiers":697},"10.1172\u002FJCI119290",{"doi":696},{"id":24,"text":699,"url":24,"identifiers":700},"Cairns JA, 1996, Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL‐ 8 production and intercellular adhesion molecule‐1 expression, J Immunol, 156, 275, 10.4049\u002Fjimmunol.156.1.275",{"doi":701},"10.4049\u002Fjimmunol.156.1.275",{"id":24,"text":703,"url":24,"identifiers":704},"10.1016\u002F0003-9861(61)90291-0",{"doi":703},{"id":24,"text":706,"url":24,"identifiers":707},"Swift ME, 1999, Impaired wound repair and delayed angiogenesis in aged mice, Lab Invest, 79, 1479",{},{"id":24,"text":709,"url":24,"identifiers":710},"10.1074\u002Fjbc.270.9.4689",{"doi":709},{"id":24,"text":712,"url":24,"identifiers":713},"10.1111\u002F1523-1747.ep12581221",{"doi":712},{"id":24,"text":715,"url":24,"identifiers":716},"10.1053\u002Fgast.1996.v110.pm8613053",{"doi":715},{"id":24,"text":718,"url":24,"identifiers":719},"Qureshi R, 1988, The role of mast cells in thioglycollate‐induced inflammation, J Immunol, 141, 2090, 10.4049\u002Fjimmunol.141.6.2090",{"doi":720},"10.4049\u002Fjimmunol.141.6.2090",{"id":24,"text":722,"url":24,"identifiers":723},"Zhang Y, 1992, Mast cells enhance the antibody‐mediated injury of skin basement membrane in mice, J Immunol, 149, 2482, 10.4049\u002Fjimmunol.149.7.2482",{"doi":724},"10.4049\u002Fjimmunol.149.7.2482",{"id":24,"text":726,"url":24,"identifiers":727},"10.1111\u002Fj.1699-0463.1999.tb01493.x",{"doi":726},{"id":24,"text":729,"url":24,"identifiers":730},"10.1126\u002Fscience.1470922",{"doi":729},{"id":24,"text":732,"url":24,"identifiers":733},"Ajuebor MN, 1999, Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL‐10, J Immunol, 162, 1685, 10.4049\u002Fjimmunol.162.3.1685",{"doi":734},"10.4049\u002Fjimmunol.162.3.1685",{"id":24,"text":736,"url":24,"identifiers":737},"10.1073\u002Fpnas.86.22.8972",{"doi":736},{"id":24,"text":739,"url":24,"identifiers":740},"10.1007\u002Fs000110050599",{"doi":739},{"id":24,"text":742,"url":24,"identifiers":743},"10.1006\u002Fbbrc.1994.2287",{"doi":742},{"id":745,"createTime":746,"updateTime":747,"relativeEntities":748,"slug":749,"properties":750,"entityType":119,"verifyStatus":120,"verifyTime":746,"verifyNote":121,"languages":767,"translateLanguages":768,"viewCount":25,"primaryUrl":769,"fullTextUrl":24,"authors":770,"publicationType":229,"publisherRelationship":822,"citationCount":872,"citationInfo":873,"publishDate":882,"publishYear":874,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":883,"openAccess":24,"references":884,"isForceReanalyzing":408},"da30e8fd-d544-4ca2-903a-1d23648ebb7f","2024-10-16T04:29:44.941+00:00","2025-02-22T21:32:38.329+00:00",[],"Honey-An-immunomodulator-in-wound-healing",{"mag":751,"keywords":753,"openalex":755,"abstract":757,"title":760,"pm":763,"doi":765},{"VOID":752},"2152543952",{"VI":754},"mật ong, chữa lành vết thương, điều chỉnh miễn dịch, cytokine, oxy hoạt tính",{"VOID":756},"W2152543952",{"EN":758,"VI":759},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Honey is a popular natural product that is used in the treatment of burns and a broad spectrum of injuries, in particular chronic wounds. The antibacterial potential of honey has been considered the exclusive criterion for its wound healing properties. The antibacterial activity of honey has recently been fully characterized in medical‐grade honeys. Recently, the multifunctional immunomodulatory properties of honey have attracted much attention. The aim of this review is to provide closer insight into the potential immunomodulatory effects of honey in wound healing. Honey and its components are able to either stimulate or inhibit the release of certain cytokines (tumor necrosis factor‐α, interleukin‐1β, interleukin‐6) from human monocytes and macrophages, depending on wound condition. Similarly, honey seems to either reduce or activate the production of reactive oxygen species from neutrophils, also depending on the wound microenvironment. The honey‐induced activation of both types of immune cells could promote debridement of a wound and speed up the repair process. Similarly, human keratinocytes, fibroblasts, and endothelial cell responses (e.g., cell migration and proliferation, collagen matrix production, chemotaxis) are positively affected in the presence of honey; thus, honey may accelerate reepithelization and wound closure. The immunomodulatory activity of honey is highly complex because of the involvement of multiple quantitatively variable compounds among honeys of different origins. The identification of these individual compounds and their contributions to wound healing is crucial for a better understanding of the mechanisms behind honey‐mediated healing of chronic wounds.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Mật ong là một sản phẩm tự nhiên phổ biến được sử dụng trong việc điều trị bỏng và nhiều loại tổn thương khác, đặc biệt là các vết thương mãn tính. Tiềm năng kháng khuẩn của mật ong đã được coi là tiêu chí duy nhất cho các thuộc tính chữa lành vết thương của nó. Hoạt động kháng khuẩn của mật ong đã được xác định hoàn toàn trong các loại mật ong y tế. Gần đây, các thuộc tính điều chỉnh miễn dịch đa chức năng của mật ong đã thu hút được nhiều sự chú ý. Mục tiêu của bài đánh giá này là cung cấp cái nhìn sâu hơn về những hiệu ứng điều chỉnh miễn dịch tiềm năng của mật ong trong việc chữa lành vết thương. Mật ong và các thành phần của nó có khả năng kích thích hoặc ức chế sự phóng thích của một số cytokine (yếu tố hoại tử khối u-alpha, interleukin-1beta, interleukin-6) từ các tế bào đơn nhân và đại thực bào của con người, tùy thuộc vào tình trạng vết thương. Tương tự, mật ong dường như có khả năng làm giảm hoặc kích hoạt việc sản xuất các loại oxy hoạt tính từ các tế bào trung tính, cũng phụ thuộc vào môi trường vi mô của vết thương. Việc kích hoạt cả hai loại tế bào miễn dịch do mật ong có thể thúc đẩy quá trình làm sạch vết thương và tăng tốc độ hồi phục. Tương tự, phản ứng của tế bào keratinocyte của người, tế bào xơ và tế bào nội mạch (ví dụ: di cư và tăng sinh tế bào, sản xuất ma trận collagen, hóa hướng động) đều được ảnh hưởng tích cực khi có mặt mật ong; do đó, mật ong có thể tăng tốc độ tái biểu mô và đóng vết thương. Hoạt động điều chỉnh miễn dịch của mật ong là rất phức tạp do sự tham gia của nhiều hợp chất biến đổi định lượng giữa các loại mật ong có nguồn gốc khác nhau. Việc xác định những hợp chất riêng lẻ này và những đóng góp của chúng vào quá trình chữa lành vết thương là rất quan trọng để hiểu rõ hơn về các cơ chế phía sau việc chữa lành vết thương mãn tính do mật ong điều hòa.",{"EN":761,"VI":762},"Honey: An immunomodulator in wound healing","Mật ong: Một chất điều chỉnh miễn dịch trong quá trình chữa lành vết thương",{"VOID":764},"24612472",{"VOID":766},"10.1111\u002Fwrr.12117",[123],[434],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fwrr.12117",[771],{"id":772,"sortIndex":25,"researcher":24,"roles":773,"affiliations":774,"properties":815,"displayName":819,"givenName":24,"familyName":24},"92c473db-e682-4839-938e-a629c5d3302b",[],[775,783,791,799,807],{"id":776,"sortIndex":25,"affiliation":777,"properties":24},"96aa192f-f001-4c87-84ec-a21a536650af",{"id":776,"createTime":24,"updateTime":24,"relativeEntities":778,"slug":24,"properties":779,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":782,"statistic":24},[],{"title":780},{"VI":781},"Department of Microbiology, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia",[],{"id":784,"sortIndex":145,"affiliation":785,"properties":24},"97742721-53e9-4607-b411-dffcd8a450da",{"id":784,"createTime":24,"updateTime":24,"relativeEntities":786,"slug":24,"properties":787,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":790,"statistic":24},[],{"title":788},{"EN":789},"Dr. J. Majtan, Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia.",[],{"id":792,"sortIndex":163,"affiliation":793,"properties":24},"79a03045-4f7e-4dd8-9ffd-f58923a13938",{"id":792,"createTime":24,"updateTime":24,"relativeEntities":794,"slug":24,"properties":795,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":798,"statistic":24},[],{"title":796},{"VI":797},"Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia",[],{"id":800,"sortIndex":179,"affiliation":801,"properties":24},"07150ccd-36f5-47c0-a3a9-22a532f8d317",{"id":800,"createTime":24,"updateTime":24,"relativeEntities":802,"slug":24,"properties":803,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":806,"statistic":24},[],{"title":804},{"EN":805},"Reprint 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C, 2005, The use of honey‐derived dressings to promote effective wound management, Prof Nurse, 20, 35",{},{"id":24,"text":967,"url":24,"identifiers":968},"10.1111\u002Fj.1365-2702.2008.02558.x",{"doi":967},{"id":24,"text":970,"url":24,"identifiers":971},"10.1111\u002Fj.1365-2648.2008.04923.x",{"doi":970},{"id":24,"text":973,"url":24,"identifiers":974},"10.1016\u002FS0002-9610(03)00211-3",{"doi":973},{"id":24,"text":976,"url":24,"identifiers":977},"10.12968\u002Fjowc.2008.17.4.28839",{"doi":976},{"id":24,"text":979,"url":24,"identifiers":980},"10.1093\u002Fjac\u002Fdkl336",{"doi":979},{"id":24,"text":982,"url":24,"identifiers":983},"10.1021\u002Fjf0256135",{"doi":982},{"id":24,"text":985,"url":24,"identifiers":986},"10.1021\u002Fjf9609284",{"doi":985},{"id":24,"text":988,"url":24,"identifiers":989},"Aljadi AM, 2003, Isolation and identification of phenolic acids in Malaysian honey with antibacterial properties, Turk J Med Sci, 33, 229",{},{"id":24,"text":991,"url":24,"identifiers":992},"10.1016\u002Fj.fct.2008.09.062",{"doi":991},{"id":24,"text":994,"url":24,"identifiers":995},"10.1021\u002Fjf034990u",{"doi":994},{"id":24,"text":997,"url":24,"identifiers":998},"10.1016\u002Fj.foodchem.2009.01.065",{"doi":997},{"id":24,"text":1000,"url":24,"identifiers":1001},"10.1016\u002Fj.foodchem.2009.11.078",{"doi":1000},{"id":24,"text":1003,"url":24,"identifiers":1004},"10.1016\u002Fj.fct.2010.06.021",{"doi":1003},{"id":24,"text":1006,"url":24,"identifiers":1007},"10.1073\u002Fpnas.92.18.8115",{"doi":1006},{"id":24,"text":1009,"url":24,"identifiers":1010},"Middleton JE, 2000, The effect of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer, Pharmacol Rev, 52, 673",{},{"id":24,"text":1012,"url":24,"identifiers":1013},"10.1021\u002Fnp960581z",{"doi":1012},{"id":24,"text":1015,"url":24,"identifiers":1016},"10.1016\u002Fj.nutres.2010.08.008",{"doi":1015},{"id":24,"text":1018,"url":24,"identifiers":1019},"10.1016\u002Fj.febslet.2004.12.048",{"doi":1018},{"id":24,"text":1021,"url":24,"identifiers":1022},"10.1016\u002F0891-5849(94)00232-9",{"doi":1021},{"id":24,"text":1024,"url":24,"identifiers":1025},"10.1016\u002FS0031-9422(97)00514-1",{"doi":1024},{"id":24,"text":1027,"url":24,"identifiers":1028},"10.1002\u002Fptr.2648",{"doi":1027},{"id":24,"text":1030,"url":24,"identifiers":1031},"10.1002\u002Fptr.2509",{"doi":1030},{"id":24,"text":1033,"url":24,"identifiers":1034},"10.1177\u002F1753425911422263",{"doi":1033},{"id":24,"text":1036,"url":24,"identifiers":1037},"Molan PC, 2002, Re‐introducing honey in the management of wounds and ulcers: theory and practice, Ostomy Wound Manage, 48, 28",{},{"id":24,"text":1039,"url":24,"identifiers":1040},"10.1006\u002Fbbrc.1999.1948",{"doi":1039},{"id":24,"text":1042,"url":24,"identifiers":1043},"Molan PC, 2011, The evidence and the rationale for the use of honey as a wound dressing, Wound Pract Res, 19, 204",{},{"id":24,"text":1045,"url":24,"identifiers":1046},"10.1155\u002F2012\u002F109636",{"doi":1045},{"id":24,"text":1048,"url":24,"identifiers":1049},"10.1007\u002Fs00403-013-1385-y",{"doi":1048},{"id":1051,"createTime":1052,"updateTime":1053,"relativeEntities":1054,"slug":1055,"properties":1056,"entityType":119,"verifyStatus":120,"verifyTime":1072,"verifyNote":121,"languages":1073,"translateLanguages":1074,"viewCount":25,"primaryUrl":1075,"fullTextUrl":24,"authors":1076,"publicationType":229,"publisherRelationship":1147,"citationCount":1196,"citationInfo":1197,"publishDate":1202,"publishYear":1198,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1203,"openAccess":24,"references":1204,"isForceReanalyzing":408},"6426f67d-16fb-4402-8df4-f9eeceb5ff2d","2024-10-16T03:17:51.681+00:00","2025-02-22T21:31:40.262+00:00",[],"Early-healing-rates-and-wound-area-measurements-are-reliable-predictors-of-later-complete-wound-closure",{"mag":1057,"keywords":1059,"openalex":1060,"abstract":1062,"title":1065,"pm":1068,"doi":1070},{"VOID":1058},"1975564954",{"VI":419},{"VOID":1061},"W1975564954",{"EN":1063,"VI":1064},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\u003Cjats:p>This study was undertaken to determine if healing rates are reliable early predictors of ultimate complete wound closure in venous leg ulcers and diabetic foot wounds. We conducted a retrospective analysis of 306 venous leg ulcers and 241 diabetic foot ulcers enrolled in two large controlled, prospective, randomized pivotal trials to compare topical wound treatments, to determine whether certain early markers of healing could be correlated with later total wound closure. Two‐sided tests at 95% confidence demonstrated that wound margin advance, initial healing rate, percent wound surface area reduction, and wound healing trajectories (all \u003Cjats:italic>p\u003C\u002Fjats:italic><0.001) were powerful predictors of complete wound healing at 12 weeks. Wounds with poor healing progress by these criteria at 4 weeks were highly likely to remain unhealed after 8 additional weeks of treatment. Analysis of the diabetic foot ulcers and venous leg ulcers subgroups separately demonstrated consistent statistical test results with high significance; similarly, the results remained valid independent of the topical treatment used. The early prediction of eventual wound healing or nonhealing using early healing rates may enable more efficient triage of patients to advanced healing technologies. We believe that these surrogate markers are robust predictors of healing regardless of wound etiology and that they merit wider use in clinical trials and routine patient care.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\u003Cjats:p>Nghiên cứu này được thực hiện để xác định xem tốc độ lành vết thương có phải là những dự đoán đáng tin cậy trong giai đoạn đầu về việc đóng vết thương hoàn toàn trong các vết loét tĩnh mạch chân và vết thương bàn chân tiểu đường hay không. Chúng tôi đã tiến hành một phân tích hồi cứu trên 306 vết loét chân tĩnh mạch và 241 vết thương bàn chân tiểu đường được đăng ký trong hai thử nghiệm lâm sàng lớn kiểm soát, có kiểm soát, ngẫu nhiên để so sánh các phương pháp điều trị vết thương tại chỗ, nhằm xác định xem một số dấu hiệu sớm về việc lành vết thương có thể liên quan đến việc đóng vết thương hoàn toàn sau đó hay không. Các bài kiểm tra hai phía ở mức độ tin cậy 95% đã chứng minh rằng sự tiến triển của bờ vết thương, tỷ lệ lành vết thương ban đầu, phần trăm giảm diện tích bề mặt vết thương và các quỹ đạo lành vết thương (tất cả \u003Cjats:italic>p\u003C\u002Fjats:italic><0.001) là những dự đoán mạnh mẽ về sự lành vết thương hoàn toàn trong 12 tuần. Những vết thương có tiến triển lành kém theo các tiêu chí này trong 4 tuần có khả năng cao sẽ không được lành sau 8 tuần điều trị bổ sung. Phân tích các nhóm vết thương bàn chân tiểu đường và vết loét chân tĩnh mạch riêng lẻ đã chứng minh rằng các kết quả kiểm tra thống kê nhất quán với ý nghĩa cao; tương tự, các kết quả vẫn hợp lệ không phụ thuộc vào phương pháp điều trị tại chỗ được sử dụng. Dự đoán sớm về việc lành vết thương cuối cùng hoặc không lành vết thương bằng cách sử dụng tốc độ lành sớm có thể cho phép phân loại bệnh nhân hiệu quả hơn để chuyển sang công nghệ lành vết thương tiên tiến. Chúng tôi tin rằng các dấu hiệu thay thế này là những dự đoán vững chắc về sự lành, bất kể nguyên nhân gây ra vết thương, và rằng chúng xứng đáng được sử dụng rộng rãi hơn trong các thử nghiệm lâm sàng và chăm sóc bệnh nhân hàng ngày.\u003C\u002Fjats:p>",{"EN":1066,"VI":1067},"Early healing rates and wound area measurements are reliable predictors of later complete wound closure","Tốc độ lành vết thương sớm và các đo lường diện tích vết thương là những dự đoán đáng tin cậy về việc đóng vết thương hoàn toàn sau này",{"VOID":1069},"18211575",{"VOID":1071},"10.1111\u002Fj.1524-475x.2007.00328.x","2024-10-16T03:17:51.680+00:00",[123],[434],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1524-475X.2007.00328.x",[1077,1094,1109,1128],{"id":1078,"sortIndex":25,"researcher":24,"roles":1079,"affiliations":1080,"properties":1089,"displayName":1091,"givenName":24,"familyName":24},"bebfe7b3-c156-4741-bedd-0727222b39e4",[],[1081],{"id":1082,"sortIndex":25,"affiliation":1083,"properties":24},"7552a4da-d96e-4775-b9b1-24c32af0f9b7",{"id":1082,"createTime":24,"updateTime":24,"relativeEntities":1084,"slug":24,"properties":1085,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1088,"statistic":24},[],{"title":1086},{"EN":1087},"Advanced BioHealing, New York,",[],{"title":1090,"openalex":1092},{"EN":1091},"Matthew Cardinal",{"VOID":1093},"A5006239542",{"id":1095,"sortIndex":145,"researcher":24,"roles":1096,"affiliations":1097,"properties":1104,"displayName":1106,"givenName":24,"familyName":24},"99b78308-e100-47b8-b7dc-6c73e3897061",[],[1098],{"id":1082,"sortIndex":25,"affiliation":1099,"properties":24},{"id":1082,"createTime":24,"updateTime":24,"relativeEntities":1100,"slug":24,"properties":1101,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1103,"statistic":24},[],{"title":1102},{"EN":1087},[],{"title":1105,"openalex":1107},{"EN":1106},"David E. Eisenbud",{"VOID":1108},"A5029097112",{"id":1110,"sortIndex":163,"researcher":24,"roles":1111,"affiliations":1112,"properties":1121,"displayName":1125,"givenName":24,"familyName":24},"363b48d0-34fe-402f-9570-0d8da59375c7",[],[1113],{"id":1114,"sortIndex":25,"affiliation":1115,"properties":24},"784a0fde-49e1-40d5-8044-a351cb13a7fa",{"id":1114,"createTime":24,"updateTime":24,"relativeEntities":1116,"slug":24,"properties":1117,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1120,"statistic":24},[],{"title":1118},{"EN":1119},"Boston University School of Medicine, Boston, Massachusetts; and.",[],{"orcid":1122,"title":1124,"openalex":1126},{"VOID":1123},"https:\u002F\u002Forcid.org\u002F0000-0003-2744-4931",{"EN":1125},"Tania J. Phillips",{"VOID":1127},"A5047822296",{"id":1129,"sortIndex":179,"researcher":24,"roles":1130,"affiliations":1131,"properties":1140,"displayName":1144,"givenName":24,"familyName":24},"6f657112-8555-45b2-a538-bfa0a1761866",[],[1132],{"id":1133,"sortIndex":25,"affiliation":1134,"properties":24},"9f34455b-45bc-4cbf-939f-8912edc7e1c4",{"id":1133,"createTime":24,"updateTime":24,"relativeEntities":1135,"slug":24,"properties":1136,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1139,"statistic":24},[],{"title":1137},{"VI":1138},"Cardiff University School of Medicine, Wales, United Kingdom",[],{"orcid":1141,"title":1143,"openalex":1145},{"VOID":1142},"https:\u002F\u002Forcid.org\u002F0000-0003-0048-3279",{"EN":1144},"Keith G Harding",{"VOID":1146},"A5057026255",{"url":24,"publisher":1148,"properties":1190},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1149,"slug":10,"properties":1150,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1155,"manageAffiliations":1164,"indexDatabases":1175,"url":93,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1151,"eissn":1152,"issn":1153,"title":1154},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1156,1160],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1157,"label":1158,"description":1159,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1161,"label":1162,"description":1163,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1165,1170],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1166,"slug":24,"properties":1167,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1169,"statistic":24},[],{"title":1168},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1171,"slug":24,"properties":1172,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1174,"statistic":24},[],{"title":1173},{"EN":52},[],[1176,1183],{"id":56,"indexDatabase":1177,"url":69,"indexYears":24,"academicFieldIds":1182,"indexDatabaseRanking":24},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1178,"label":1179,"description":1180,"key":65,"publicationTags":1181,"standard":24},[],{"EN":61,"VI":61},{"EN":63,"VI":64},[67,68],[71,72,73,74],{"id":76,"indexDatabase":1184,"url":87,"indexYears":88,"academicFieldIds":1189,"indexDatabaseRanking":92},{"id":78,"createTime":24,"updateTime":24,"relativeEntities":1185,"label":1186,"description":1187,"key":84,"publicationTags":1188,"standard":24},[],{"EN":81,"VI":81},{"EN":81,"VI":83},[86],[90,91],{"issue":1191,"pages":1192,"volume":1194},{"VOID":275},{"VOID":1193},"19-22",{"VOID":1195},"16",173,{"total":1196,"publishYear":1198,"statisticByYear":1199},2008,{"2012":876,"2013":573,"2014":1200,"2015":569,"2016":574,"2017":572,"2018":571,"2019":876,"2020":572,"2021":878,"2022":1201,"2023":574,"2024":1200},10,19,"2008-01-01",[67,92],[1205,1208,1212,1215,1218,1221,1224,1227,1230,1233,1236,1239,1242,1245,1248,1252,1256,1259],{"id":24,"text":1206,"url":24,"identifiers":1207},"Gilman T., 1990, Parameter for measurement of wound closure, Wounds, 2, 95",{},{"id":24,"text":1209,"url":24,"identifiers":1210},"Tallman P, 1997, Initial rate of healing predicts complete healing of venous leg ulcers, Arch Dermatol, 133, 1231, 10.1001\u002Farchderm.1997.03890460053006",{"doi":1211},"10.1001\u002Farchderm.1997.03890460053006",{"id":24,"text":1213,"url":24,"identifiers":1214},"10.2337\u002Fdiacare.26.6.1879",{"doi":1213},{"id":24,"text":1216,"url":24,"identifiers":1217},"Robson M, 2000, Wound healing trajectories as predictors of effectiveness of therapeutic agents, Arch Dermatol, 135, 773",{},{"id":24,"text":1219,"url":24,"identifiers":1220},"10.1111\u002Fj.1742-4801.2006.00178.x",{"doi":1219},{"id":24,"text":1222,"url":24,"identifiers":1223},"Hill D, 2004, Initial healing rates of venous ulcers, are they useful as predictors of healing?, 188, 22S",{},{"id":24,"text":1225,"url":24,"identifiers":1226},"10.1016\u002F0190-9622(93)70061-W",{"doi":1225},{"id":24,"text":1228,"url":24,"identifiers":1229},"Gilman T., 2004, Wound outcomes, the utility of surface measures, 3, 125",{},{"id":24,"text":1231,"url":24,"identifiers":1232},"Cukjati D, 2000, Measures of wound healing rate, 22nd EMBS Int Conf Proc, 1, 765",{},{"id":24,"text":1234,"url":24,"identifiers":1235},"10.1046\u002Fj.1523-1747.2002.19629.x",{"doi":1234},{"id":24,"text":1237,"url":24,"identifiers":1238},"10.1016\u002FS0002-9610(03)00294-0",{"doi":1237},{"id":24,"text":1240,"url":24,"identifiers":1241},"Donohue K, 2003, Healing rate as a prognostic indicator of complete healing, a reappraisal, 15, 71",{},{"id":24,"text":1243,"url":24,"identifiers":1244},"10.1111\u002Fj.1067-1927.2004.012207.x",{"doi":1243},{"id":24,"text":1246,"url":24,"identifiers":1247},"10.1001\u002Farchderm.134.12.1571",{"doi":1246},{"id":24,"text":1249,"url":24,"identifiers":1250},"Gilman T., 2003, A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks, Br J Dermat, 149, 885, 10.1046\u002Fj.1365-2133.2003.05575.x",{"doi":1251},"10.1046\u002Fj.1365-2133.2003.05575.x",{"id":24,"text":1253,"url":24,"identifiers":1254},"Kantor J, 2003, Kantor and Margolis, reply to Dr Gilman, Br J Dermat, 149, 885, 10.1046\u002Fj.1365-2133.2003.05576.x",{"doi":1255},"10.1046\u002Fj.1365-2133.2003.05576.x",{"id":24,"text":1257,"url":24,"identifiers":1258},"10.2337\u002Fdiacare.26.6.1696",{"doi":1257},{"id":24,"text":1260,"url":24,"identifiers":1261},"10.1016\u002FS0741-5214(96)80021-8",{"doi":1260},{"id":1263,"createTime":1264,"updateTime":1265,"relativeEntities":1266,"slug":1267,"properties":1268,"entityType":119,"verifyStatus":120,"verifyTime":1285,"verifyNote":121,"languages":1286,"translateLanguages":1287,"viewCount":25,"primaryUrl":1288,"fullTextUrl":24,"authors":1289,"publicationType":229,"publisherRelationship":1326,"citationCount":1376,"citationInfo":1377,"publishDate":1381,"publishYear":1378,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1382,"openAccess":24,"references":1383,"isForceReanalyzing":408},"70aab7dd-a8bc-4c21-8c1b-640c03cbcb9c","2024-10-16T00:28:23.981+00:00","2025-02-22T21:30:43.151+00:00",[],"Oxidative-stress-in-chronic-venous-leg-ulcers",{"mag":1269,"keywords":1271,"openalex":1273,"abstract":1275,"title":1278,"pm":1281,"doi":1283},{"VOID":1270},"1985058433",{"VI":1272},"vết loét tĩnh mạch, căng thẳng oxy hóa, viêm, vết thương mãn tính",{"VOID":1274},"W1985058433",{"EN":1276,"VI":1277},"\u003Cjats:p>Venous leg ulcers are common and cause considerable morbidity in the population. As healing may be slow or may never be achieved, ulcers create persistent and substantial demands on clinical resources. Great efforts have been made to accelerate tissue repair in chronic venous leg ulcers with limited success. This may at least be partly due to the limited knowledge on the microenvironment of chronic wounds. In fact, the tremendous impact of the microenvironmental conditions on the outcome of wound healing has increasingly become apparent. Oxidative stress as a consequence of an imbalance in the prooxidant‐antioxidant homeostasis in chronic wounds is thought to drive a deleterious sequence of events finally resulting in the nonhealing state. The majority of reactive oxygen species are most likely released by neutrophils and macrophages and to an unknown extent from resident fibroblasts and endothelial cells. As the inflammatory phase does not resolve in chronic wounds, the load of reactive oxygen species persists over a long period of time with subsequent continuous damage and perpetuation of the inflammation. In this article, we will critically discuss recent findings that support the role of oxidative stress in the pathophysiology of nonhealing chronic venous leg ulcers.\u003C\u002Fjats:p>","\u003Cjats:p>Vết loét tĩnh mạch ở chân rất phổ biến và gây ra nhiều bệnh tật cho dân số. Do quá trình lành vết thương có thể diễn ra chậm hoặc không bao giờ đạt được, các vết loét tạo ra những yêu cầu liên tục và đáng kể đối với nguồn lực lâm sàng. Đã có rất nhiều nỗ lực để tăng tốc độ phục hồi mô trong các vết loét tĩnh mạch mãn tính nhưng thành công còn hạn chế. Nguyên nhân có thể ít nhiều do hiểu biết hạn chế về môi trường vi mô của các vết thương mãn tính. Thực tế là tác động to lớn của các điều kiện môi trường vi mô đối với kết quả lành vết thương ngày càng rõ ràng. Căng thẳng oxy hóa do sự mất cân bằng trong cân bằng prooxidant‐antioxidant ở các vết thương mãn tính được cho là nguyên nhân kích thích một chuỗi sự kiện gây hại dẫn đến trạng thái không lành. Phần lớn các loài oxy phản ứng rất có thể được giải phóng bởi bạch cầu trung tính và đại thực bào, và một mức độ không xác định từ các nguyên bào sợi và tế bào nội mô cư trú. Khi giai đoạn viêm không được giải quyết trong các vết thương mãn tính, tải lượng các loài oxy phản ứng kéo dài trong một thời gian dài gây ra tổn thương liên tục và duy trì tình trạng viêm. Trong bài viết này, chúng tôi sẽ thảo luận một cách phê phán các phát hiện gần đây hỗ trợ vai trò của căng thẳng oxy hóa trong bệnh sinh của các vết loét tĩnh mạch mãn tính không lành.\u003C\u002Fjats:p>",{"EN":1279,"VI":1280},"Oxidative stress in chronic venous leg ulcers","Căng thẳng oxy hóa trong vết loét tĩnh mạch mãn 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the past decade, a variety of advanced silver‐based dressings have been developed. There are considerable variations in the structure, composition, and silver content of these new preparations. In the present study, we examined five commercially available silver‐based dressings (Acticoat™, Aquacel\u003Cjats:sup>®\u003C\u002Fjats:sup> Ag, Contreet\u003Cjats:sup>®\u003C\u002Fjats:sup> Foam, PolyMem\u003Cjats:sup>®\u003C\u002Fjats:sup> Silver, Urgotul\u003Cjats:sup>®\u003C\u002Fjats:sup>SSD). We assessed their cytotoxicity in a monolayer cell culture, a tissue explant culture model, and a mouse excisional wound model. The results showed that Acticoat™, Aquacel\u003Cjats:sup>®\u003C\u002Fjats:sup> Ag, and Contreet\u003Cjats:sup>®\u003C\u002Fjats:sup> Foam, when pretreated with specific solutes, were likely to produce the most significant cytotoxic effects on both cultured keratinocytes and fibroblasts, while PolyMem\u003Cjats:sup>®\u003C\u002Fjats:sup> Silver and Urgotul\u003Cjats:sup>®\u003C\u002Fjats:sup>SSD demonstrated the least cytotoxicity. The cytotoxicity correlated with the silver released from the dressings as measured by silver concentration in the culture medium. In the tissue explant culture model, in which the epidermal cell proliferation was evaluated, all silver dressings resulted in a significant delay of reepithelialization. In the mouse excisional wound model, Acticoat™ and Contreet\u003Cjats:sup>®\u003C\u002Fjats:sup> Foam indicated a strong inhibition of wound reepithelialization on the postwounding‐day 7. These findings may, in part, explain the clinical observations of delayed wound healing or inhibition of wound epithelialization after the use of certain topical silver dressings. Caution should be exercised in using silver‐based dressings in clean superficial wounds such as donor sites and superficial burns and also when cultured cells are being applied to wounds.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\u003Cjats:p>Trong thập kỷ qua, nhiều loại băng gạc chứa bạc tiên tiến đã được phát triển. Có sự khác biệt đáng kể về cấu trúc, thành phần và hàm lượng bạc của các chế phẩm mới này. Trong nghiên cứu hiện tại, chúng tôi đã khảo sát năm loại băng gạc chứa bạc có sẵn trên thị trường (Acticoat™, Aquacel\u003Cjats:sup>®\u003C\u002Fjats:sup> Ag, Contreet\u003Cjats:sup>®\u003C\u002Fjats:sup> Foam, PolyMem\u003Cjats:sup>®\u003C\u002Fjats:sup> Silver, Urgotul\u003Cjats:sup>®\u003C\u002Fjats:sup>SSD). Chúng tôi đã đánh giá độc tính tế bào của chúng trong mô hình nuôi cấy tế bào đơn lớp, mô hình nuôi cấy mô và mô hình vết thương cắt bỏ ở chuột. Kết quả cho thấy rằng Acticoat™, Aquacel\u003Cjats:sup>®\u003C\u002Fjats:sup> Ag và Contreet\u003Cjats:sup>®\u003C\u002Fjats:sup> Foam, khi được tiền xử lý bằng các chất hòa tan cụ thể, có khả năng gây ra ảnh hưởng độc tính tế bào đáng kể nhất đối với cả tế bào biểu bì và tế bào sợi, trong khi PolyMem\u003Cjats:sup>®\u003C\u002Fjats:sup> Silver và Urgotul\u003Cjats:sup>®\u003C\u002Fjats:sup>SSD cho thấy độc tính thấp nhất. Độc tính tế bào tương quan với hàm lượng bạc được giải phóng từ các băng gạc, được đo bằng nồng độ bạc trong môi trường nuôi cấy. Trong mô hình nuôi cấy mô, trong đó sự phát triển tế bào biểu bì được đánh giá, tất cả các băng gạc chứa bạc đều dẫn đến sự chậm trễ đáng kể trong việc tái biểu mô. Trong mô hình vết thương cắt bỏ ở chuột, Acticoat™ và Contreet\u003Cjats:sup>®\u003C\u002Fjats:sup> Foam cho thấy sự ức chế mạnh mẽ trong việc tái biểu mô vết thương vào ngày 7 sau phẫu thuật. Những phát hiện này có thể phần nào giải thích những quan sát lâm sàng về việc làm chậm quá trình chữa lành vết thương hoặc ức chế tái biểu mô vết thương sau khi sử dụng một số băng gạc bạc tại chỗ nhất định. Cần thận trọng khi sử dụng các băng gạc chứa bạc cho những vết thương sạch nông, chẳng hạn như vùng cho tạng và bỏng nông, cũng như khi các tế bào được nuôi cấy được áp dụng cho vết thương.\u003C\u002Fjats:p>",{"EN":1684,"VI":1685},"A comparative study of the cytotoxicity of silver‐based dressings in monolayer cell, tissue explant, and animal models","Nghiên cứu so sánh về độc tính của các băng gạc chứa bạc trong mô hình tế bào đơn lớp, mẫu mô và động vật",{"VOID":1687},"17244325",{"VOID":1689},"10.1111\u002Fj.1524-475x.2006.00190.x",[123],[434],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1524-475X.2006.00190.x",[1694,1711,1726,1741,1758,1775,1792],{"id":1695,"sortIndex":25,"researcher":24,"roles":1696,"affiliations":1697,"properties":1706,"displayName":1708,"givenName":24,"familyName":24},"bee4211d-a6d3-4e6a-9dc9-36e3fc62339b",[],[1698],{"id":1699,"sortIndex":25,"affiliation":1700,"properties":24},"a987af14-fa7c-4fa1-8c3d-f34b11bc4475",{"id":1699,"createTime":24,"updateTime":24,"relativeEntities":1701,"slug":24,"properties":1702,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1705,"statistic":24},[],{"title":1703},{"VI":1704},"Division of Plastic and Reconstructive Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong",[],{"title":1707,"openalex":1709},{"EN":1708},"Andrew Burd",{"VOID":1710},"A5028168232",{"id":1712,"sortIndex":145,"researcher":24,"roles":1713,"affiliations":1714,"properties":1721,"displayName":1723,"givenName":24,"familyName":24},"0728aaf6-d914-4dc0-aca8-4246a026cfb4",[],[1715],{"id":1699,"sortIndex":25,"affiliation":1716,"properties":24},{"id":1699,"createTime":24,"updateTime":24,"relativeEntities":1717,"slug":24,"properties":1718,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1720,"statistic":24},[],{"title":1719},{"VI":1704},[],{"title":1722,"openalex":1724},{"EN":1723},"Chi H Kwok",{"VOID":1725},"A5026807354",{"id":1727,"sortIndex":163,"researcher":24,"roles":1728,"affiliations":1729,"properties":1736,"displayName":1738,"givenName":24,"familyName":24},"225d8569-340b-497d-814a-c56a60104eb3",[],[1730],{"id":1699,"sortIndex":25,"affiliation":1731,"properties":24},{"id":1699,"createTime":24,"updateTime":24,"relativeEntities":1732,"slug":24,"properties":1733,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1735,"statistic":24},[],{"title":1734},{"VI":1704},[],{"title":1737,"openalex":1739},{"EN":1738},"Siu Chun Hung",{"VOID":1740},"A5029719165",{"id":1742,"sortIndex":179,"researcher":24,"roles":1743,"affiliations":1744,"properties":1753,"displayName":1755,"givenName":24,"familyName":24},"6d823f70-cc15-4cf4-b833-4c23e0e250c8",[],[1745],{"id":1746,"sortIndex":25,"affiliation":1747,"properties":24},"69ae6a62-047d-4640-8fe3-bd59df022872",{"id":1746,"createTime":24,"updateTime":24,"relativeEntities":1748,"slug":24,"properties":1749,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1752,"statistic":24},[],{"title":1750},{"VI":1751},"Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong",[],{"title":1754,"openalex":1756},{"EN":1755},"Hui S Chan",{"VOID":1757},"A5088217846",{"id":1759,"sortIndex":197,"researcher":24,"roles":1760,"affiliations":1761,"properties":1768,"displayName":1772,"givenName":24,"familyName":24},"f871749b-ff7d-4861-90dc-25c49350e975",[],[1762],{"id":1699,"sortIndex":25,"affiliation":1763,"properties":24},{"id":1699,"createTime":24,"updateTime":24,"relativeEntities":1764,"slug":24,"properties":1765,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1767,"statistic":24},[],{"title":1766},{"VI":1704},[],{"orcid":1769,"title":1771,"openalex":1773},{"VOID":1770},"https:\u002F\u002Forcid.org\u002F0000-0002-0024-2240",{"EN":1772},"Hua Gu",{"VOID":1774},"A5101779953",{"id":1776,"sortIndex":213,"researcher":24,"roles":1777,"affiliations":1778,"properties":1785,"displayName":1789,"givenName":24,"familyName":24},"d016d28d-1761-4202-9cab-0bc56de710ce",[],[1779],{"id":1746,"sortIndex":25,"affiliation":1780,"properties":24},{"id":1746,"createTime":24,"updateTime":24,"relativeEntities":1781,"slug":24,"properties":1782,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1784,"statistic":24},[],{"title":1783},{"VI":1751},[],{"orcid":1786,"title":1788,"openalex":1790},{"VOID":1787},"https:\u002F\u002Forcid.org\u002F0000-0001-8922-5609",{"EN":1789},"W. 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SM, 2006, Silver based wound dressings and topical agents for treating diabetic foot ulcers, Cochrane Database Syst Rev, 25, CD005082",{},{"id":24,"text":1884,"url":24,"identifiers":1885},"10.1021\u002Fpr0504079",{"doi":1884},{"id":24,"text":1887,"url":24,"identifiers":1888},"Lansdown ABG., 2002, Silver I, its antibacterial properties and mechanism of action, 11, 125",{},{"id":24,"text":1890,"url":24,"identifiers":1891},"Lansdown ABG., 2005, A guide to the properties and uses of silver dressings in wound care, Professional Nurse, 20, 41",{},{"id":24,"text":1893,"url":24,"identifiers":1894},"10.1016\u002FS0305-4179(04)90000-9",{"doi":1893},{"id":24,"text":1896,"url":24,"identifiers":1897},"10.1016\u002FS0142-9612(02)00414-3",{"doi":1896},{"id":24,"text":1899,"url":24,"identifiers":1900},"10.1097\u002F01.BCR.0000112331.72232.1B",{"doi":1899},{"id":24,"text":1902,"url":24,"identifiers":1903},"Ip M, 2006, Antimicrobial activities of silver dressings, an in vitro comparison, 55, 59",{},{"id":24,"text":1905,"url":24,"identifiers":1906},"10.1016\u002F0022-4804(89)90069-3",{"doi":1905},{"id":24,"text":1908,"url":24,"identifiers":1909},"10.1016\u002F0022-4804(92)90086-F",{"doi":1908},{"id":24,"text":1911,"url":24,"identifiers":1912},"Poon VK, 2004, In vitro cytotoxity of silver, implication for clinical wound care, 30, 140",{},{"id":24,"text":1914,"url":24,"identifiers":1915},"Burd DA, 1991, Hyaluronan and wound healing, a new perspective, 44, 579",{},{"id":24,"text":1917,"url":24,"identifiers":1918},"10.1111\u002Fj.1067-1927.2004.12404.x",{"doi":1917},{"id":24,"text":1920,"url":24,"identifiers":1921},"Hidalgo E, 1998, Silver nitrate, antimicrobial activity related to cytotoxicity in cultured human fibroblasts, 11, 140",{},{"id":24,"text":1923,"url":24,"identifiers":1924},"Lansdown ABG., 2004, A review of the use of silver in wound care, facts and fallacies, 13, S6",{},{"id":24,"text":1926,"url":24,"identifiers":1927},"Parsons D, 2005, Silver antimicrobial dressings in wound management, a comparison of antibacterial, physical, and chemical characteristics, 17, 222",{},{"id":24,"text":1929,"url":24,"identifiers":1930},"AndersonMB.Letter to Editor.Wound2006 March.",{},{"id":24,"text":1932,"url":24,"identifiers":1933},"DolmerM LarsenK JensenK.In vitro silver release profiles for various antimicrobial dressings. Paper presented at the 2nd WUWHS Meeting Paris July 2004.",{},{"id":24,"text":1935,"url":24,"identifiers":1936},"Lansdown AB, 1997, Silver aids healing in the sterile skin wound, experimental studies in the laboratory rat, 137, 728",{},{"id":24,"text":1938,"url":24,"identifiers":1939},"Innes ME, 2001, The use of silver coated dressings on donor site wounds, a prospective, controlled matched pair study, 27, 621",{},{"id":24,"text":1941,"url":24,"identifiers":1942},"10.1016\u002FS0305-4179(01)00119-X",{"doi":1941},{"id":24,"text":1944,"url":24,"identifiers":1945},"10.1016\u002Fj.jhin.2006.02.005",{"doi":1944},{"id":24,"text":1947,"url":24,"identifiers":1948},"10.12968\u002Fjowc.2005.14.4.26762",{"doi":1947},{"id":1950,"createTime":1951,"updateTime":1952,"relativeEntities":1953,"slug":1954,"properties":1955,"entityType":119,"verifyStatus":120,"verifyTime":1971,"verifyNote":121,"languages":1972,"translateLanguages":1973,"viewCount":25,"primaryUrl":1974,"fullTextUrl":24,"authors":1975,"publicationType":229,"publisherRelationship":2102,"citationCount":2151,"citationInfo":2152,"publishDate":2164,"publishYear":2153,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2165,"openAccess":24,"references":2166,"isForceReanalyzing":408},"40b477bd-c4cd-4c85-a54c-e57d891b4900","2024-09-28T04:13:06.606+00:00","2025-02-22T21:28:49.800+00:00",[],"A-review-of-the-scientific-evidence-for-biofilms-in-wounds",{"mag":1956,"keywords":1958,"openalex":1959,"abstract":1961,"title":1964,"pm":1967,"doi":1969},{"VOID":1957},"1818684172",{"VI":419},{"VOID":1960},"W1818684172",{"EN":1962,"VI":1963},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Both chronic and acute dermal wounds are susceptible to infection due to sterile loss of the innate barrier function of the skin and dermal appendages, facilitating the development of microbial communities, referred to as biofilms, within the wound environment. Microbial biofilms are implicated in both the infection of wounds and failure of those wounds to heal. The aim of this review is to provide a summary of published papers detailing biofilms in wounds, the effect they have on infection and wound healing, and detailing methods employed for their detection. The studies highlighted within this paper provide evidence that biofilms reside within the chronic wound and represent an important mechanism underlying the observed, delayed healing and infection. The reasons for this include both protease activity and immunological suppression. Furthermore, a lack of responsiveness to an array of antimicrobial agents has been due to the biofilms’ ability to inherently resist antimicrobial agents. It is imperative that effective strategies are developed, tested prospectively, and employed in chronic wounds to support the healing process and to reduce infection rates. It is increasingly apparent that adoption of a biofilm‐based management approach to wound care, utilizing the “antibiofilm tool box” of therapies, to kill and prevent reattachment of microorganisms in the biofilm is producing the most positive clinical outcomes and prevention of infection.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Cả vết thương mãn tính và cấp tính đều dễ bị nhiễm trùng do sự mất chức năng rào cản bẩm sinh của da và các phần phụ của da, tạo điều kiện thuận lợi cho sự phát triển của các cộng đồng vi sinh vật, được gọi là biofilm, trong môi trường vết thương. Biofilm vi sinh vật có liên quan đến việc nhiễm trùng các vết thương và sự thất bại trong quá trình chữa lành của những vết thương đó. Mục tiêu của bài tổng quan này là cung cấp một tóm tắt các tài liệu đã được công bố chi tiết về biofilm trong các vết thương, tác động của chúng đến nhiễm trùng và quá trình chữa lành vết thương, đồng thời mô tả các phương pháp được áp dụng để phát hiện chúng. Các nghiên cứu được nêu bật trong bài báo này cung cấp chứng cứ cho thấy biofilm tồn tại trong vết thương mãn tính và đại diện cho một cơ chế quan trọng gây ra sự chậm chữa lành và nhiễm trùng được quan sát. Những lý do cho điều này bao gồm cả hoạt động của protease và sự ức chế miễn dịch. Hơn nữa, sự thiếu phản ứng với một loạt các tác nhân kháng khuẩn là do khả năng của biofilm trong việc chống lại các tác nhân kháng khuẩn. Việc phát triển, thử nghiệm một cách hợp lý và áp dụng các chiến lược hiệu quả trong vết thương mãn tính để hỗ trợ quá trình chữa lành và giảm tỷ lệ nhiễm trùng là điều cực kỳ cần thiết. 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R, 2008, Surgical site infections: biofilms, dehiscence and wound healing, US Dermatol Touch Briefings, 56",{},{"id":24,"text":2512,"url":24,"identifiers":2513},"10.1111\u002Fj.1742-481X.2011.00774.x",{"doi":2512},{"id":24,"text":2515,"url":24,"identifiers":2516},"10.1111\u002Fj.1742‐481X.2011.00903.x",{"doi":2515},{"id":24,"text":2518,"url":24,"identifiers":2519},"10.1128\u002FAEM.71.6.2970-2978.2005",{"doi":2518},{"id":24,"text":2521,"url":24,"identifiers":2522},"10.1099\u002F00222615-28-1-9",{"doi":2521},{"id":24,"text":2524,"url":24,"identifiers":2525},"10.1111\u002Fj.1574-6968.2009.01668.x",{"doi":2524},{"id":24,"text":2527,"url":24,"identifiers":2528},"PercivalSL BowlerP.Understanding the effects of bacterial communities and biofilms on wound healing. July 2004. Available athttp:\u002F\u002Fwww.worldwidewounds.com(accessed December 8 2011).",{},{"id":24,"text":2530,"url":24,"identifiers":2531},"Cooper R, 2006, Biofilms, wound infection and the issue of control, Wounds, 2, 48",{},{"id":24,"text":2533,"url":24,"identifiers":2534},"Saye DE, 2007, Recurring and antimicrobial‐resistant infections: considering the potential role of biofilms in clinical practice, Ostomy Wound Manage, 53, 46",{},{"id":24,"text":2536,"url":24,"identifiers":2537},"10.7748\u002Fns2009.04.23.32.64.c7152",{"doi":2536},{"id":24,"text":2539,"url":24,"identifiers":2540},"Rhoades D, 2007, Biofilms: coming of age, 131",{},{"id":2542,"createTime":2543,"updateTime":2544,"relativeEntities":2545,"slug":2546,"properties":2547,"entityType":119,"verifyStatus":120,"verifyTime":2543,"verifyNote":121,"languages":2565,"translateLanguages":2566,"viewCount":25,"primaryUrl":2567,"fullTextUrl":24,"authors":2568,"publicationType":229,"publisherRelationship":2657,"citationCount":2705,"citationInfo":2706,"publishDate":2715,"publishYear":874,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2716,"openAccess":24,"references":2717,"isForceReanalyzing":408},"a2de6c8e-0737-49ff-8a56-35a7cbde8988","2024-09-27T18:19:10.332+00:00","2025-02-22T21:27:53.019+00:00",[],"Clinical-application-of-growth-factors-and-cytokines-in-wound-healing",{"mag":2548,"keywords":2550,"pmc":2551,"openalex":2553,"abstract":2555,"title":2558,"pm":2561,"doi":2563},{"VOID":2549},"1586551928",{"VI":419},{"VOID":2552},"4812574",{"VOID":2554},"W1586551928",{"EN":2556,"VI":2557},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Wound healing is a complex and dynamic biological process that involves the coordinated efforts of multiple cell types and is executed and regulated by numerous growth factors and cytokines. There has been a drive in the past two decades to study the therapeutic effects of various growth factors in the clinical management of nonhealing wounds (e.g., pressure ulcers, chronic venous ulcers, diabetic foot ulcers). For this review, we conducted an online search of \u003Cjats:styled-content style=\"fixed-case\">M\u003C\u002Fjats:styled-content>edline\u002FPubMed and critically analyzed the literature regarding the role of growth factors and cytokines in the management of these wounds. We focused on currently approved therapies, emerging therapies, and future research possibilities. In this review, we discuss four growth factors and cytokines currently being used on and off label for the healing of wounds. These include granulocyte‐macrophage colony‐stimulating factor, platelet‐derived growth factor, vascular endothelial growth factor, and basic fibroblast growth factor. While the clinical results of using growth factors and cytokines are encouraging, many studies involved a small sample size and are disparate in measured endpoints. Therefore, further research is required to provide definitive evidence of efficacy.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Quá trình lành vết thương là một quá trình sinh học phức tạp và năng động, liên quan đến sự phối hợp của nhiều loại tế bào và được thực hiện cũng như điều chỉnh bởi nhiều yếu tố tăng trưởng và cytokine khác nhau. Trong hai thập kỷ qua, đã có những nỗ lực nghiên cứu tác dụng điều trị của nhiều yếu tố tăng trưởng trong việc quản lý lâm sàng các vết thương không lành (ví dụ: loét do áp lực, loét tĩnh mạch mạn tính, loét bàn chân tiểu đường). Để thực hiện bài tổng quan này, chúng tôi đã tiến hành tìm kiếm trực tuyến trên \u003Cjats:styled-content style=\"fixed-case\">M\u003C\u002Fjats:styled-content>edline\u002FPubMed và phân tích một cách nghiêm túc tài liệu được đăng tải liên quan đến vai trò của các yếu tố tăng trưởng và cytokine trong việc quản lý những vết thương này. Chúng tôi tập trung vào các liệu pháp đã được phê duyệt, các liệu pháp mới nổi và những khả năng nghiên cứu trong tương lai. Trong bài tổng quan này, chúng tôi thảo luận về bốn yếu tố tăng trưởng và cytokine hiện đang được sử dụng theo thẩm quyền và không theo thẩm quyền cho việc lành vết thương. Các yếu tố này bao gồm yếu tố kích thích dòng tế bào đại thực bào bạch cầu, yếu tố tăng trưởng xuất phát từ tiểu cầu, yếu tố tăng trưởng nội mạc mạch máu, và yếu tố tăng trưởng nguyên bào sợi cơ bản. Mặc dù kết quả lâm sàng khi sử dụng các yếu tố tăng trưởng và cytokine là đáng khích lệ, nhưng nhiều nghiên cứu có kích thước mẫu nhỏ và các điểm đo lường khác nhau. Do đó, cần có thêm nhiều nghiên cứu để cung cấp chứng cứ xác thực về hiệu quả.",{"EN":2559,"VI":2560},"Clinical application of growth factors and cytokines in wound healing","Ứng dụng lâm sàng của các yếu tố tăng trưởng và cytokine trong quá trình lành vết thương",{"VOID":2562},"24942811",{"VOID":2564},"10.1111\u002Fwrr.12205",[123],[434],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fwrr.12205",[2569,2586,2601,2618],{"id":2570,"sortIndex":25,"researcher":24,"roles":2571,"affiliations":2572,"properties":2581,"displayName":2583,"givenName":24,"familyName":24},"8091cd2b-deaf-4e37-9782-e281213d1ac1",[],[2573],{"id":2574,"sortIndex":25,"affiliation":2575,"properties":24},"2fc2bae3-9b4f-453f-93fa-6d170ec3e10c",{"id":2574,"createTime":24,"updateTime":24,"relativeEntities":2576,"slug":24,"properties":2577,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2580,"statistic":24},[],{"title":2578},{"EN":2579},"Division of Wound Healing and Regenerative Medicine, Department of Surgery, Winthrop University Hospital\u002FStony Brook University School of Medicine, Mineola, New York",[],{"title":2582,"openalex":2584},{"EN":2583},"Stephan 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Diabetic Ulcer Study Group, J Am Coll Surg, 183, 61",{},{"id":24,"text":3072,"url":24,"identifiers":3073},"10.1097\u002F00129334-200309000-00015",{"doi":3072},{"id":24,"text":3075,"url":24,"identifiers":3076},"10.1046\u002Fj.1524-475X.2002.10603.x",{"doi":3075},{"id":24,"text":3078,"url":24,"identifiers":3079},"10.1007\u002Fs00268-009-0024-4",{"doi":3078},{"id":24,"text":3081,"url":24,"identifiers":3082},"10.1016\u002Fj.jamcollsurg.2008.09.018",{"doi":3081},{"id":24,"text":3084,"url":24,"identifiers":3085},"10.2119\u002Fmolmed.2009.00149",{"doi":3084},{"id":24,"text":3087,"url":24,"identifiers":3088},"10.1186\u002F1479-5876-6-75",{"doi":3087},{"id":3090,"createTime":3091,"updateTime":3092,"relativeEntities":3093,"slug":3094,"properties":3095,"entityType":119,"verifyStatus":120,"verifyTime":3091,"verifyNote":121,"languages":3113,"translateLanguages":3114,"viewCount":25,"primaryUrl":3115,"fullTextUrl":24,"authors":3116,"publicationType":229,"publisherRelationship":3284,"citationCount":3334,"citationInfo":3335,"publishDate":3350,"publishYear":3336,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":3351,"openAccess":24,"references":3352,"isForceReanalyzing":408},"4817aeab-938c-4bf3-934d-67d9410ce00f","2024-09-23T08:26:55.141+00:00","2025-02-22T21:26:55.782+00:00",[],"Human-skin-wounds-A-major-and-snowballing-threat-to-public-health-and-the-economy",{"mag":3096,"keywords":3098,"pmc":3099,"openalex":3101,"abstract":3103,"title":3106,"pm":3109,"doi":3111},{"VOID":3097},"2056064788",{"VI":419},{"VOID":3100},"2810192",{"VOID":3102},"W2056064788",{"EN":3104,"VI":3105},"\u003Cjats:title>ABSTRACT\u003C\u002Fjats:title>\u003Cjats:p>In the United States, chronic wounds affect 6.5 million patients. An estimated excess of US$25 billion is spent annually on treatment of chronic wounds and the burden is rapidly growing due to increasing health care costs, an aging population and a sharp rise in the incidence of diabetes and obesity worldwide. The annual wound care products market is projected to reach $15.3 billion by 2010. Chronic wounds are rarely seen in individuals who are otherwise healthy. In fact, chronic wound patients frequently suffer from \"highly branded\" diseases such as diabetes and obesity. This seems to have overshadowed the significance of wounds per se as a major health problem. For example, NIH's Research Portfolio Online Reporting Tool (RePORT; \u003Cjats:ext-link xmlns:xlink=\"http:\u002F\u002Fwww.w3.org\u002F1999\u002Fxlink\" xlink:href=\"http:\u002F\u002Freport.nih.gov\u002F\">http:\u002F\u002Freport.nih.gov\u002F\u003C\u002Fjats:ext-link>), directed at providing access to estimates of funding for various disease conditions does list several rare diseases but does not list wounds. Forty million inpatient surgical procedures were performed in the United States in 2000, followed closely by 31.5 million outpatient surgeries. The need for post‐surgical wound care is sharply on the rise. Emergency wound care in an acute setting has major significance not only in a war setting but also in homeland preparedness against natural disasters as well as against terrorism attacks. An additional burden of wound healing is the problem of skin scarring, a $12 billion annual market. The immense economic and social impact of wounds in our society calls for allocation of a higher level of attention and resources to understand biological mechanisms underlying cutaneous wound complications.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\u003Cjats:p>Tại Hoa Kỳ, các vết thương mãn tính ảnh hưởng đến 6,5 triệu bệnh nhân. Ước tính mỗi năm tiêu tốn hơn 25 tỷ USD cho việc điều trị các vết thương mãn tính và gánh nặng này đang gia tăng nhanh chóng do chi phí chăm sóc sức khỏe tăng, dân số già đi và sự gia tăng đột ngột trong tỷ lệ mắc bệnh tiểu đường và béo phì trên toàn cầu. Thị trường sản phẩm chăm sóc vết thương hàng năm được dự đoán sẽ đạt 15,3 tỷ USD vào năm 2010. Các vết thương mãn tính hiếm khi xuất hiện ở những cá nhân khác khỏe mạnh. Thực tế, bệnh nhân có vết thương mãn tính thường phải chịu đựng \"các bệnh được thương hiệu cao\" như bệnh tiểu đường và béo phì. Điều này có vẻ đã làm lu mờ sự quan trọng của vết thương nói riêng như một vấn đề sức khỏe chính. Ví dụ, Công cụ Báo cáo Danh mục Nghiên cứu của NIH (RePORT; \u003Cjats:ext-link xmlns:xlink=\"http:\u002F\u002Fwww.w3.org\u002F1999\u002Fxlink\" xlink:href=\"http:\u002F\u002Freport.nih.gov\u002F\">http:\u002F\u002Freport.nih.gov\u002F\u003C\u002Fjats:ext-link>), nhằm cung cấp quyền truy cập vào ước tính nguồn tài trợ cho các tình trạng bệnh khác nhau có liệt kê một số bệnh hiếm nhưng không liệt kê vết thương. Bốn mươi triệu ca phẫu thuật nội trú đã được thực hiện tại Hoa Kỳ vào năm 2000, tiếp theo là 31,5 triệu ca phẫu thuật ngoại trú. Nhu cầu chăm sóc vết thương sau phẫu thuật đang gia tăng mạnh mẽ. Chăm sóc vết thương khẩn cấp trong các tình huống cấp tính có ý nghĩa lớn không chỉ trong bối cảnh chiến tranh mà còn trong việc chuẩn bị quốc gia chống lại thiên tai cũng như chống lại các cuộc tấn công khủng bố. Một gánh nặng bổ sung của việc lành vết thương là vấn đề sẹo trên da, một thị trường hàng năm trị giá 12 tỷ USD. Ảnh hưởng kinh tế và xã hội to lớn của các vết thương trong xã hội của chúng ta yêu cầu phân bổ một mức độ chú ý và nguồn lực cao hơn để hiểu các cơ chế sinh học cơ bản liên quan đến các biến chứng của vết thương ngoài da.\u003C\u002Fjats:p>",{"EN":3107,"VI":3108},"Human skin wounds: A major and snowballing threat to public health and the economy","Vết thương trên da người: Một mối đe dọa lớn và đang gia tăng đối với sức khỏe cộng đồng và kinh tế",{"VOID":3110},"19903300",{"VOID":3112},"10.1111\u002Fj.1524-475x.2009.00543.x",[123],[434],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1524-475X.2009.00543.x",[3117,3136,3153,3170,3189,3214,3231,3248,3267],{"id":3118,"sortIndex":25,"researcher":24,"roles":3119,"affiliations":3120,"properties":3129,"displayName":3133,"givenName":24,"familyName":24},"44712172-4913-40b1-8bd0-30cbb83e986e",[],[3121],{"id":3122,"sortIndex":25,"affiliation":3123,"properties":24},"5f25999a-1caf-48f5-aa3f-0cc88570efdc",{"id":3122,"createTime":24,"updateTime":24,"relativeEntities":3124,"slug":24,"properties":3125,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3128,"statistic":24},[],{"title":3126},{"EN":3127},"Department of Surgery, The Ohio State University Comprehensive Wound Center, Columbus, Ohio,",[],{"orcid":3130,"title":3132,"openalex":3134},{"VOID":3131},"https:\u002F\u002Forcid.org\u002F0000-0003-3151-5202",{"EN":3133},"Chandan K. 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This process involves the coordinated efforts of several cell types including keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets. The migration, infiltration, proliferation, and differentiation of these cells will culminate in an inflammatory response, the formation of new tissue and ultimately wound closure. This complex process is executed and regulated by an equally complex signaling network involving numerous growth factors, cytokines and chemokines. Of particular importance is the epidermal growth factor (EGF) family, transforming growth factor beta (TGF‐β) family, fibroblast growth factor (FGF) family, vascular endothelial growth factor (VEGF), granulocyte macrophage colony stimulating factor (GM‐CSF), platelet‐derived growth factor (PDGF), connective tissue growth factor (CTGF), interleukin (IL) family, and tumor nerosis factor‐α family. Currently, patients are treated by three growth factors: PDGF‐BB, bFGF, and GM‐CSF. Only PDGF‐BB has successfully completed randomized clinical trials in the Unites States. With gene therapy now in clinical trial and the discovery of biodegradable polymers, fibrin mesh, and human collagen serving as potential delivery systems other growth factors may soon be available to patients. This review will focus on the specific roles of these growth factors and cytokines during the wound healing process.\u003C\u002Fjats:p>","\u003Cjats:title>TÓM TẮT\u003C\u002Fjats:title>\u003Cjats:p>Quá trình lành vết thương là một quá trình phức tạp đa tế bào, được bảo tồn qua tiến hóa, mà trong da, nhằm mục đích phục hồi hàng rào. Quá trình này liên quan đến sự phối hợp của nhiều loại tế bào khác nhau bao gồm tế bào keratinocyte, tế bào fibroblast, tế bào nội mô, đại thực bào và tiểu cầu. Sự di chuyển, thâm nhập, phát triển và phân hóa của các tế bào này sẽ culminate trong một phản ứng viêm, sự hình thành mô mới và cuối cùng là khép vết thương. Quá trình phức tạp này được thực hiện và điều chỉnh bởi một mạng lưới tín hiệu cũng phức tạp không kém, liên quan đến nhiều yếu tố tăng trưởng, cytokine và chemokine. Đặc biệt quan trọng là các gia đình yếu tố tăng trưởng biểu bì (EGF), yếu tố tăng trưởng chuyển đổi beta (TGF-β), yếu tố tăng trưởng fibroblast (FGF), yếu tố tăng trưởng nội mô mạch (VEGF), yếu tố kích thích đại thực bào bạch cầu trung tính (GM-CSF), yếu tố tăng trưởng tiểu cầu (PDGF), yếu tố tăng trưởng mô liên kết (CTGF), gia đình interleukin (IL), và gia đình yếu tố hoại tử khối u-alpha (TNF-α). Hiện tại, bệnh nhân được điều trị bằng ba yếu tố tăng trưởng: PDGF-BB, bFGF và GM-CSF. Chỉ có PDGF-BB đã hoàn thành thành công các thử nghiệm lâm sàng ngẫu nhiên tại Hoa Kỳ. Với liệu pháp gen hiện đang trong thử nghiệm lâm sàng và việc phát hiện ra các polyme phân hủy sinh học, lưới fibrin và collagen người, phục vụ như các hệ thống cung cấp tiềm năng, các yếu tố tăng trưởng khác có thể sớm có sẵn cho bệnh nhân. Bài đánh giá này sẽ tập trung vào các vai trò cụ thể của những yếu tố tăng trưởng và cytokine này trong quá trình lành vết thương.\u003C\u002Fjats:p>",{"EN":3729,"VI":3730},"PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing","BÀI VIẾT GÓC: Các yếu tố tăng trưởng và cytokine trong quá trình lành vết thương",{"VOID":3732},"19128254",{"VOID":3734},"10.1111\u002Fj.1524-475x.2008.00410.x",[123],[434],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1524-475X.2008.00410.x",[3739,3762,3775,3794,3808],{"id":3740,"sortIndex":25,"researcher":24,"roles":3741,"affiliations":3742,"properties":3759,"displayName":2583,"givenName":24,"familyName":24},"b6cbb631-6e9d-4b15-98a5-1758e45cba80",[],[3743,3751],{"id":3744,"sortIndex":25,"affiliation":3745,"properties":24},"ef3724ea-9343-4d30-8250-a48bb9e42f5d",{"id":3744,"createTime":24,"updateTime":24,"relativeEntities":3746,"slug":24,"properties":3747,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3750,"statistic":24},[],{"title":3748},{"EN":3749},"Tissue Engineering, Repair and Regeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, New York,",[],{"id":3752,"sortIndex":145,"affiliation":3753,"properties":24},"0e900ea6-9465-4c02-a9d9-945da87747ce",{"id":3752,"createTime":24,"updateTime":24,"relativeEntities":3754,"slug":24,"properties":3755,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3758,"statistic":24},[],{"title":3756},{"VI":3757},"University of Rochester School of Medicine and Dentistry, Rochester, New York",[],{"title":3760,"openalex":3761},{"EN":2583},{"VOID":2585},{"id":3763,"sortIndex":145,"researcher":24,"roles":3764,"affiliations":3765,"properties":3772,"displayName":2615,"givenName":24,"familyName":24},"b6d968b0-c6fd-4391-a782-dbd4f5e7efbd",[],[3766],{"id":3744,"sortIndex":25,"affiliation":3767,"properties":24},{"id":3744,"createTime":24,"updateTime":24,"relativeEntities":3768,"slug":24,"properties":3769,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3771,"statistic":24},[],{"title":3770},{"EN":3749},[],{"title":3773,"openalex":3774},{"EN":2615},{"VOID":2617},{"id":3776,"sortIndex":163,"researcher":24,"roles":3777,"affiliations":3778,"properties":3787,"displayName":3791,"givenName":24,"familyName":24},"f04b7392-718e-4685-ab05-85ae4bdad8f6",[],[3779],{"id":3780,"sortIndex":25,"affiliation":3781,"properties":24},"88d6eb98-9a5d-4e70-827f-90cc1cf8e515",{"id":3780,"createTime":24,"updateTime":24,"relativeEntities":3782,"slug":24,"properties":3783,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":3786,"statistic":24},[],{"title":3784},{"EN":3785},"Wound Healing Laboratory, Columbia University College of Physicians and Surgeons, New York, and",[],{"orcid":3788,"title":3790,"openalex":3792},{"VOID":3789},"https:\u002F\u002Forcid.org\u002F0000-0002-0715-1915",{"EN":3791},"Michael S. 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