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disposition and protein binding of ibuprofen (IBU) in premature infants were studied for use in the prevention of intraventricular hemorrhage and closure of patent ductus arteriosus. The kinetic profile of i.v. IBU lysine (10 mg\u002Fkg bolus) given within the first 3 h after birth was studied in 21 premature neonates (mean birthweight = 944.7 g, range: 575–1450 g; gestational age: 26.8 weeks, range: 22–31 weeks). Blood samples (0.3 ml\u002Fsample) were obtained at time 0 and at 1, 3, 6, 12, 24, 48, and 72 h post‐dose for IBU by high‐performance liquid chromatography (HPLC). Kinetic analyses assumed applicability of one open‐compartment model and calculations from the model‐independent areas under the time concentration curve (AUC). Data (mean ± SEM) show that apparent volume of distribution (AVd) was 62.1 ± 3.9 ml\u002Fkg, plasma \u003Cjats:italic>t\u003C\u002Fjats:italic>\u003Cjats:sub>1\u002F2\u003C\u002Fjats:sub> beta was 30.5 ± 4.2 h, elimination rate constant (k\u003Cjats:sub>el\u003C\u002Fjats:sub>) was 0.032 ± 0.004 h\u003Cjats:sup>‐1\u003C\u002Fjats:sup>plasma clearance was 2.06 ± 0.33 ml\u002Fkg\u002Fh and plasma concentration (Cp) at 1 h was 180.6 ±11.1 mg\u002F1. Gestational age and birthweight were not related to drug elimination. In 10 neonates, IBU maintenance dose of 5 mg\u002Fkg once daily on days 2 and 3 generated mean Cp of 116.6 ± 54.5 mg\u002F1 and 113.6 ± 58.2mg\u002F1, respectively. Protein binding by ultrafiltration and capillary electrophoresis showed that the percentage bound IBU was significantly lower in full term cord plasma (94.98 ± 0.39%, \u003Cjats:italic>n\u003C\u002Fjats:italic>= 26) compared to adult plasma protein (mean ± SE = 98.73 ± 0.31%, \u003Cjats:italic>n\u003C\u002Fjats:italic>= 8, \u003Cjats:italic>p\u003C\u002Fjats:italic> &lt; 0.0001). Compared to data from adults and older children, IBU elimination is markedly prolonged in neonates and protein binding is slightly lower. Thus, investigational and clinical therapeutic regimens should be adjusted to account for decreased drug disposition to ensure safe and effective therapy.\u003C\u002Fjats:p>",{"EN":447},"Pharmacokinetics and protein binding of intravenous ibuprofen in the premature newborn infant",{"VOID":449},"9099319",{"VOID":451},"10.1111\u002Fj.1651-2227.1997.tb08892.x",[219],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1651-2227.1997.tb08892.x",[455,477,508,523,540,563,578,595],{"id":456,"sortIndex":116,"researcher":19,"roles":457,"affiliations":458,"properties":470},"56779fa2-41c7-4996-a0f7-e7d0d638f0b8",[],[459],{"id":460,"sortIndex":20,"affiliation":461,"properties":19},"00c91ffb-b87a-48b0-9e40-81acab705085",{"id":462,"createTime":463,"updateTime":464,"relativeEntities":465,"slug":466,"properties":467,"entityType":47,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"syncStatus":18,"languages":19,"translateLanguages":19,"viewCount":20},"68619aaa-48f1-4d89-9aa8-8276315af3ec","2024-01-09T16:01:03.327+00:00","2024-11-25T23:52:11.331+00:00",[],"University-of-California-Irvine-Long-Beach-California",{"title":468},{"VI":469},"University of California, Irvine Long Beach, California",{"openalex":471,"orcid":473,"title":475},{"VOID":472},"A5004357574",{"VOID":474},"https:\u002F\u002Forcid.org\u002F0000-0001-7923-5221",{"EN":476},"Sylvain Chemtob",{"id":478,"sortIndex":104,"researcher":19,"roles":479,"affiliations":480,"properties":501},"3739cce4-960c-40f2-aafa-466b0b47923d",[],[481,491],{"id":482,"sortIndex":20,"affiliation":483,"properties":19},"883a7fc8-2887-4084-9689-b3af1e1fa2cc",{"id":484,"createTime":485,"updateTime":485,"relativeEntities":486,"slug":487,"properties":488,"entityType":47,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"syncStatus":18,"languages":19,"translateLanguages":19,"viewCount":20},"5f2de295-7b13-461e-9444-7568fb86433c","2024-11-25T23:52:11.383+00:00",[],"Departments-of-Pediatrics-Pharmacology-Therapeutics-McGill-University-and-the-Department-of-Neonatology-Jewish-General-Hospital-Lady-Davis-Institute-for-Medical-Research-Montreal-Canada",{"title":489},{"EN":490},"Departments of Pediatrics, Pharmacology & Therapeutics, McGill University and the Department of Neonatology, Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal Canada",{"id":492,"sortIndex":114,"affiliation":493,"properties":19},"cf279ec0-6cf2-453d-816b-3ad40301483d",{"id":494,"createTime":495,"updateTime":495,"relativeEntities":496,"slug":497,"properties":498,"entityType":47,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"syncStatus":18,"languages":19,"translateLanguages":19,"viewCount":20},"38c5da65-ad1e-495f-9ce8-293ceca60e5d","2024-11-25T23:52:11.393+00:00",[],"Long-Beach-Memorial-Medical-Center",{"title":499},{"EN":500},"Long Beach Memorial Medical Center",{"openalex":502,"orcid":504,"title":506},{"VOID":503},"A5090153690",{"VOID":505},"https:\u002F\u002Forcid.org\u002F0000-0002-3597-5399",{"EN":507},"Houchang D. 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pharmacological consequences, J PharmePharmacol, 35, 693",{},{"id":19,"text":718,"url":19,"identifiers":719},"Lee EJA, 1985, Stezeoselec ive disrosition of ibuprofen enantiomer in man, Bo J Clin Pharmacol, 99, 663",{},{"id":721,"createTime":722,"updateTime":722,"relativeEntities":723,"slug":724,"properties":725,"entityType":215,"verifyStatus":216,"verifyTime":739,"verifyNote":217,"syncStatus":18,"languages":740,"translateLanguages":19,"viewCount":20,"primaryUrl":741,"fullTextUrl":19,"authors":742,"publicationType":345,"publisherRelationship":882,"citationCount":918,"citationInfo":919,"publishDate":921,"publishYear":922,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":19,"openAccess":19,"references":923,"isForceReanalyzing":432},"1e61022e-c8c0-4bad-9c90-1e3f19fa1382","2025-01-04T23:38:21.909+00:00",[],"Methaemoglobinaemia-among-neonates-in-a-neonatal-intensive-care-unit",{"mag":726,"keywords":728,"openalex":729,"abstract":731,"title":733,"pm":735,"doi":737},{"VOID":727},"2125867441",{},{"VOID":730},"W2125867441",{"EN":732},"\u003Cjats:p>After detection of a few clinical cases of methaemoglobinaemia (methb) in our NICU, a prospective clinical study was undertaken to determine the extent of the problem and to identify the causes. Consequently, during the following 8 months all haemoglobin tests included simultaneous measurements of methb on an OSM 3 hemoximeter (Radiometer): 8% (\u003Cjats:italic>n\u003C\u002Fjats:italic>= 33) of 415 neonates were found to be methb positive (denned as ≥6% methb). Mean methb was 19% (range 6.5–45.5%). Maximum methb concentrations were found on day 4–31 postpartum (mean 12 days) and the number of days with a positive methb sample ranged from 1 to 18 days (mean 6 days). About 40% of the neonates born at 25–30 weeks of gestation and 60%) with a birth weight &lt; 1000 g were methb positive. Also, there was a negative correlation between the size of the methb positive concentration and gestational age (\u003Cjats:italic>r\u003C\u002Fjats:italic>=– 0.38,\u003Cjats:italic>p\u003C\u002Fjats:italic>= 0.02). Measurements of C–reactive protein and leucocytes, NADH reductase, pH, CI, nitrate and nitrite were carried out in methb positive patients. The tests were repeated 1 week after cessation of methb. The only significant difference was an increase in NADH reductase at the second measurement. Likewise, a wide range of clinical parameters were registered and they occurred with a higher frequency among the methb positive patients when compared with a methb negative control group matched with regard to gestational age and the closest possible birth weight. The mean birth weight of methb positive patients was 1170g and that of negative controls 1380g (\u003Cjats:italic>p &lt;\u003C\u002Fjats:italic> 0.006). Epidemiological data and intervention studies indicated that para–chloraniline was the direct cause of the epidemic. The substance was derived from 0.02% chlorhexidine being inadvertently added to the humidifying fluid of the new incubators. Treatment of severe methb in premature neonates with 0.3–1.0mg methylene blue\u002Fkg body weight proved efficient. In conclusion, premature neonates developed severe methb when exposed to even small amounts of para–chloraniline. Immaturity, severe illness, the time exposed to para–chloraniline and low concentrations of NADH reductase probably played a part while other well known factors such as increased nitrite and nitrate concentrations, acidosis and hyperchloraemia did not seem to be significant.\u003C\u002Fjats:p>",{"EN":734},"Methaemoglobinaemia among neonates in a neonatal intensive care 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M., 1962, Growth at Adolescence",{},{"id":19,"text":1197,"url":19,"identifiers":1198},"Wallau F., 1939, Körperbautypus und Menstruation, Zbl Gynäk, 63, 1830",{},{"id":19,"text":1200,"url":19,"identifiers":1201},"Wallau F., 1952, Über die Akzeleration der Menarche, Zbl Gynäk, 74, 615",{},{"id":19,"text":1203,"url":19,"identifiers":1204},"10.1016\u002FS0140-6736(51)91795-3",{"doi":1203},{"id":19,"text":1206,"url":19,"identifiers":1207},"10.1093\u002Fjn\u002F66.3.345",{"doi":1206},{"id":1209,"createTime":1210,"updateTime":1210,"relativeEntities":1211,"slug":1212,"properties":1213,"entityType":215,"verifyStatus":216,"verifyTime":1210,"verifyNote":217,"syncStatus":18,"languages":1227,"translateLanguages":19,"viewCount":20,"primaryUrl":1228,"fullTextUrl":19,"authors":1229,"publicationType":345,"publisherRelationship":1306,"citationCount":1342,"citationInfo":1343,"publishDate":1345,"publishYear":1346,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":19,"openAccess":19,"references":1347,"isForceReanalyzing":432},"5580a0cc-d29c-476b-a626-79ca0ba9abfd","2024-09-24T23:04:21.417+00:00",[],"Psychometric-properties-of-the-Swedish-PedsQL-Pediatric-Quality-of-Life-Inventory-4-0-generic-core-scales",{"mag":1214,"keywords":1216,"openalex":1217,"abstract":1219,"title":1221,"pm":1223,"doi":1225},{"VOID":1215},"2082161770",{},{"VOID":1218},"W2082161770",{"EN":1220},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:bold>Aim: \u003C\u002Fjats:bold> To study the psychometric performance of the Swedish version of the Pediatric Quality of Life Inventory (PedsQL) 4.0 generic core scales in a general child population in Sweden.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods: \u003C\u002Fjats:bold> PedsQL forms were distributed to 2403 schoolchildren and 888 parents in two different school settings. Reliability and validity was studied for self‐reports and proxy reports, full forms and short forms. Confirmatory factor analysis tested the factor structure and multigroup confirmatory factor analysis tested measurement invariance between boys and girls.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results: \u003C\u002Fjats:bold> Test‐retest reliability was demonstrated for all scales and internal consistency reliability was shown with α value exceeding 0.70 for all scales but one (self‐report short form: social functioning). Child‐parent agreement was low to moderate. The four‐factor structure of the PedsQL and factorial invariance across sex subgroups were confirmed for the self‐report forms and for the proxy short form, while model fit indices suggested improvement of several proxy full‐form scales.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Conclusion: \u003C\u002Fjats:bold> The Swedish PedsQL 4.0 generic core scales are a reliable and valid tool for health‐related quality of life (HRQoL) assessment in Swedish child populations. The proxy full form, however, should be used with caution. The study also support continued use of the PedsQL as a four‐factor model, capable of revealing meaningful HRQoL differences between boys and girls.\u003C\u002Fjats:p>",{"EN":1222},"Psychometric properties of the Swedish PedsQL, Pediatric Quality of Life Inventory 4.0 generic core 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Kinderh., 61, 1",{},{"id":19,"text":1863,"url":19,"identifiers":1864},"Rietschel: Ibid. 68 289 1937.",{},{"id":19,"text":1866,"url":19,"identifiers":1867},"10.1136\u002Fadc.12.68.119",{"doi":1866},{"id":19,"text":1869,"url":19,"identifiers":1870},"Ruge C., 1878, Ztsehr. Gebh. u. Gynäk., 2, 31",{},{"id":19,"text":1872,"url":19,"identifiers":1873},"Sante L. R., 1928, Amer. Journ. Roentg., 20, 213",{},{"id":19,"text":1875,"url":19,"identifiers":1876},"Schmidt M. B., 1937, Monatschr. Kinderh., 68, 287",{},{"id":19,"text":1878,"url":19,"identifiers":1879},"Schuler F., 1938, Arch. Kinderh., 113, 160",{},{"id":19,"text":1881,"url":19,"identifiers":1882},"Schönfeld, 1937, Monatschr. Kinderh., 68, 288",{},{"id":19,"text":1884,"url":19,"identifiers":1885},"10.1001\u002Farchpedi.1939.01990040171013",{"doi":1884},{"id":19,"text":1887,"url":19,"identifiers":1888},"Slot G., 1938, Brit. Journ. Childr. Dis., 35, 116",{},{"id":19,"text":1890,"url":19,"identifiers":1891},"10.1148\u002F23.2.173",{"doi":1890},{"id":19,"text":1893,"url":19,"identifiers":1894},"Storts B. P., 1936, Arch. Pediatr., 53, 744",{},{"id":19,"text":1896,"url":19,"identifiers":1897},"10.1007\u002FBF02225011",{"doi":1896},{"id":19,"text":1899,"url":19,"identifiers":1900},"10.1001\u002Farchpedi.1938.01980130119010",{"doi":1899},{"id":19,"text":1902,"url":19,"identifiers":1903},"Tengbergen J. van E., 1936, Fortschr. Geb. Röntgenstr., 53, 240",{},{"id":19,"text":1905,"url":19,"identifiers":1906},"10.1111\u002Fj.1651-2227.1925.tb17250.x",{"doi":1905},{"id":19,"text":1908,"url":19,"identifiers":1909},"10.1007\u002FBF02248306",{"doi":1908},{"id":19,"text":1911,"url":19,"identifiers":1912},"10.1001\u002Fjama.1924.02660160030009",{"doi":1911},{"id":19,"text":1914,"url":19,"identifiers":1915},"Wieland E., 1937, Monatschr. Kinderh., 68, 281",{},{"id":19,"text":1917,"url":19,"identifiers":1918},"10.1001\u002Farchpedi.1936.04140020104010",{"doi":1917},{"id":19,"text":1920,"url":19,"identifiers":1921},"Wiskott, 1937, Monatschr. Kinderh., 68, 288",{},{"id":19,"text":1923,"url":19,"identifiers":1924},"Ylppö A., 1935, The Diseases of Children, 488",{},{"id":1926,"createTime":1927,"updateTime":1927,"relativeEntities":1928,"slug":1929,"properties":1930,"entityType":215,"verifyStatus":216,"verifyTime":1927,"verifyNote":217,"syncStatus":18,"languages":1944,"translateLanguages":19,"viewCount":20,"primaryUrl":1945,"fullTextUrl":19,"authors":1946,"publicationType":345,"publisherRelationship":2002,"citationCount":1342,"citationInfo":2036,"publishDate":2038,"publishYear":386,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":19,"openAccess":19,"references":2039,"isForceReanalyzing":432},"6fa953fb-13b0-4796-98d8-5c0e5880be5c","2024-09-12T22:04:09.747+00:00",[],"Follow-up-results-of-different-treatment-programs-for-obese-children",{"mag":1931,"keywords":1933,"openalex":1934,"abstract":1936,"title":1938,"pm":1940,"doi":1942},{"VOID":1932},"1981397932",{},{"VOID":1935},"W1981397932",{"EN":1937},"\u003Cjats:p> \u003Cjats:italic>Objective\u003C\u002Fjats:italic> Many approaches have been tried in order to tackle the problem of obesity in children, but most of them have failed to achieve long‐term weight loss. Cognitive behaviour therapy tends to predict good prospects. So far, no studies have investigated the surplus value of introducing a “healthy‐eating” lifestyle program instead of a strict diet prescription, in combination with the principles of cognitive behaviour therapy. Therefore, a new program was designed. The second aim of the study was to evaluate the impact of different forms of therapeutic contact. \u003Cjats:italic>Subjects and methods\u003C\u002Fjats:italic>: The obese group consisted of 205 children seeking treatment, and a control group of 54 obese school children. The effects of the program were evaluated by means of a pre‐test\u002Fpost‐test design with a 1‐y follow‐up. Subjects were assigned to different therapeutic conditions: group therapy, individual therapy, summer camp or “advice in one session”. \u003Cjats:italic>Results\u003C\u002Fjats:italic>: A progressive and significant loss of weight for all therapeutic conditions was noticeable. The reduction continued at least 6 months after completing therapy. The control group, however, showed weight evolution in the opposite sense. \u003Cjats:italic>Conclusions\u003C\u002Fjats:italic>: A replication of the positive effect of CBT was found in a broad sample of clinically obese children, even without strict diet prescription. Our hypothesis that group approach will result in a better outcome is borne out.\u003C\u002Fjats:p>",{"EN":1939},"Follow‐up results of different treatment programs for obese 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The causes of brain damage were neonatal asphyxia, hypoglycaemia, circulatory disturbance associated with congenital heart diseases, and other perinatal events in five, three, two and three, respectively. Severe, moderate and mild mental retardation were present in three, five and five, respectively. Of the seven children who could walk alone, six had ataxia and one spastic diplegia; the remaining six manifested truncal instability. The ataxia was deduced to have resulted from cerebral lesions.\u003C\u002Fjats:p>",{"EN":2137},"Clinical profiles of subjects with subcortical leukomalacia and border‐zone infarction revealed by 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