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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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The main objectives of the journal include: providing an intellectual platform for Vietnamese and international scholars; promoting interdisciplinary studies in social sciences and humanities; becoming the leading journal in social sciences and humanities in Vietnam; being indexed by worldwide databases and having academic recognition internationally in the near future.\\nThe journal is currently indexed by Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services and Vietnam National University’s digital archive.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Journal of Social Sciences and Humanities-Vietnam\"},{\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"ISSN 2354-1172, email: tapchikhxhnv@gmail.com, tckhxhnv@vnu.edu.vn\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Được thành lập ngày 31\u002F8\u002F2015 (giấy phép hoạt động số 155\u002FGP-BVHTT ngày 11 tháng 5 năm 2015 của Bộ Thông tin và Truyền thông, mã số tiêu chuẩn quốc tế ISSN 2354-1172), Tạp chí Khoa học Xã hội và Nhân văn (Journal of Social Sciences and Humanities) là ấn phẩm khoa học chính thức, duy nhất của Trường Đại học Khoa học Xã hội và Nhân văn, ĐHQG Hà Nội, phát triển và kế thừa Chuyên san Khoa học Xã hội và Nhân văn, Tạp chí Khoa học, ĐHQG Hà Nội.\\nTạp chí xuất bản định kỳ (04 số tiếng Việt\u002Fnăm và 02 số tiếng Anh\u002Fnăm), có nhiệm vụ \"},{\"attributes\":{\"italic\":true},\"insert\":\"công bố, giới thiệu các công trình nghiên cứu khoa học khoa học xã hội và nhân văn của các tác giả là các nhà khoa học trong và ngoài nước, phục vụ giảng dạy, học tập và nghiên cứu khoa học\"},{\"insert\":\". Hội đồng biên tập của Tạp chí hiện bao gồm 33 nhà khoa học có uy tín trong nước và quốc tế. Tạp chí tập trung và ưu tiên đăng tải những bài báo theo định hướng của tinh thần cởi mở, sáng tạo, nhanh chóng vươn lên để tiếp cận và sánh ngang với các tạp chí có uy tín hàng đầu của khu vực và trên thế giới. Nội dung chính của Tạp chí bao gồm các Bài nghiên cứu (khoảng 6000 đến 15000 từ), các bài điểm sách, thông tin khoa học (khoảng 300 đến 1500 từ) được trình bày theo đúng cấu trúc và chuẩn mực của một tạp chí khoa học.\\nCác bài viết của Tạp chí hiện đang được trích dẫn bởi Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services.\\nMọi thông tin xin liên hệ: \"},{\"attributes\":{\"italic\":true},\"insert\":\"Phòng Tạp chí, 701 - E, Trường Đại học Khoa học Xã hội và Nhân văn, 336 Nguyễn Trãi, Thanh Xuân, Hà Nội. ĐT: 024.35581984; email: tckhxhnv@vnu.edu.vn \"},{\"insert\":\"hoặc \"},{\"attributes\":{\"italic\":true},\"insert\":\"tapchikhxhnv@gmail.com \"},{\"insert\":\"\\n\"}]}",{"EN":494,"VI":495},"VNU Journal of Social Sciences and Humanities","Tạp chí Khoa học Xã hội và Nhân văn",[101,102],[],[499],{"id":500,"createTime":501,"updateTime":502,"relativeEntities":503,"slug":504,"properties":505,"entityType":98,"verifyStatus":25,"verifyTime":509,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":222,"url":26,"parentIds":510,"statistic":511},"8b6e349b-0daf-4895-9c3f-85f30f1bfd42","2023-07-31T12:55:58.430+00:00","2026-06-19T02:30:07.899+00:00",[],"Tr%C6%B0%E1%BB%9Dng-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Khoa-h%E1%BB%8Dc-X%C3%A3-h%E1%BB%99i-v%C3%A0-Nh%C3%A2n-v%C4%83n-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-H%C3%A0-N%E1%BB%99i",{"title":506},{"EN":507,"VI":508},"VNU University of Social Sciences and Humanities","Trường Đại học Khoa học Xã hội và Nhân văn, Đại học Quốc gia Hà Nội","2023-08-02T15:28:49.057+00:00",[],{"impactFactor":36,"impactFactorByYear":512,"i10Index":59,"i10IndexLast5Year":115,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":518,"totalCitationByYear":519,"totalCitationPerPublication":520,"totalCitationPerPublicationByYear":521,"hindexLast5Year":162,"hindex":162},{"2016":229,"2017":230,"2018":229,"2021":230,"2022":58,"2023":513,"2024":38},0.15,365,{"2013":115,"2014":158,"2015":125,"2016":252,"2017":44,"2018":516,"2019":286,"2020":396,"2021":259,"2022":517,"2023":396,"2024":115,"2025":59,"2026":115},21,42,169,{"2015":283,"2016":135,"2017":52,"2018":50,"2019":298,"2020":53,"2021":359,"2022":115,"2023":115},0.46,{"2015":266,"2016":57,"2017":57,"2018":522,"2019":523,"2020":524,"2021":368,"2022":229,"2023":39},0.38,0.32,0.37,[],"http:\u002F\u002Fjournal.ussh.vnu.edu.vn\u002Findex.php\u002Fvjossh","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F2b8d7b12-2d20-4777-be98-077f44f03c69\u002F0bd0751202944a4b4165b482e6e623e4.png",{"impactFactor":36,"impactFactorByYear":529,"i10Index":162,"i10IndexLast5Year":115,"totalPublication":530,"totalPublicationByYear":531,"totalCitation":537,"totalCitationByYear":538,"totalCitationPerPublication":343,"totalCitationPerPublicationByYear":540,"hindexLast5Year":135,"hindex":135},{"2016":341,"2017":39,"2018":229,"2019":38,"2020":110,"2021":231,"2022":231,"2023":341,"2024":39},764,{"2015":255,"2016":245,"2017":532,"2018":259,"2019":533,"2020":534,"2021":535,"2022":536,"2023":534,"2024":254,"2025":50},111,106,68,92,89,265,{"2015":539,"2016":241,"2017":168,"2018":51,"2019":349,"2020":260,"2021":244,"2022":298,"2023":114},46,{"2015":541,"2016":523,"2017":524,"2018":290,"2019":542,"2020":522,"2021":523,"2022":57,"2023":39},1.48,0.63,{"id":544,"createTime":545,"updateTime":546,"relativeEntities":547,"slug":548,"properties":549,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":558,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":50,"subjectFields":559,"manageAffiliations":560,"indexDatabases":561,"url":562,"thumbnailPath":563,"statistic":564,"gsStatistic":26,"type":26,"analyzePriority":26},"6ec01bd0-15c0-469a-86ac-41339076ae0a","2023-08-10T07:08:33.153+00:00","2026-01-31T21:19:06.362+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Da-li%E1%BB%85u-h%E1%BB%8Dc-Vi%E1%BB%87t-Nam",{"country":550,"issn":551,"introduce":553,"title":555},{"VOID":15},{"VOID":552},"18594824",{"VI":554},"{\"ops\":[{\"insert\":\"Tạp chí “Da liễu học Việt Nam” (Tiếng Anh: Vietnamese Journal of Dermatology and Venereology) thuộc Hội Da liễu Việt Nam, xuất bản 4 số mỗi năm bằng tiếng Việt hoặc tiếng Anh.\\nTạp chí Da liễu học Việt Nam hoạt động với mục đích, tôn chỉ là phổ biến, trao đổi thông tin trong lĩnh vực chuyên ngành da liễu; đăng tải các công trình nghiên cứu khoa học; chuyển giao công nghệ - kinh tế và khoa học kỹ thuật liên quan đến lĩnh vực da liễu.\\nPhạm vi của tạp chí là tất cả các bài báo khoa học, bài tổng quan, giới thiệu ca lâm sàng, … có liên quan tới chuyên ngành da liễu trong và ngoài nước. Tạp chí công bố các công trình nghiên cứu liên quan đến mô hình bệnh tật, các phương pháp chẩn đoán, điều trị, dự phòng và phục hồi chức năng các bệnh thuộc chuyên ngành da liễu. Ngoài ra, tạp chí còn đăng tải các bài tổng quan, cập nhật thông tin, kiến thức, hướng dẫn chẩn đoán, điều trị trong chuyên ngành da liễu trong nước và quốc tế; đăng tải các bài ca lâm sàng đặc biệt trong chuyên ngành da liễu.\\nTạp chí Da liễu học Việt Nam được biết tới là một tạp chí chuyên ngành có uy tín trong lĩnh vực da liễu. Các bài báo về nghiên cứu khoa học đăng trong Tạp chí được bình duyệt một cách nghiêm ngặt bởi ít nhất 2 chuyên gia. Hội đồng biên tập tạp chí bao gồm các nhà khoa học có uy tín (Giáo sư, Phó Giáo sư, Tiến sĩ, Bác sĩ…) trong chuyên ngành da liễu nhằm đảm bảo chất lượng và tính khách quan, khoa học cho các bài viết đăng trên Tạp chí.\\n\"}]}",{"EN":556,"VI":557},"Vietnamese Journal of Dermatology and Venereology","Tạp chí Da liễu học Việt Nam","Admin Import",[],[],[],"https:\u002F\u002Fvjdv.vn\u002Findex.php\u002Fvjdv","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F6ec01bd0-15c0-469a-86ac-41339076ae0a\u002F3cbc81720e58429dc7b1c4d7ab1935ca.jpg",{"impactFactor":36,"impactFactorByYear":565,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":566,"totalPublicationByYear":567,"totalCitation":116,"totalCitationByYear":570,"totalCitationPerPublication":109,"totalCitationPerPublicationByYear":571,"hindexLast5Year":115,"hindex":115},{"2023":38,"2024":230},182,{"2022":568,"2023":45,"2024":569},69,56,{"2022":52,"2023":115},{"2022":40,"2023":229},{"id":573,"createTime":574,"updateTime":575,"relativeEntities":576,"slug":577,"properties":578,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":587,"translateLanguages":26,"viewCount":283,"subjectFields":588,"manageAffiliations":589,"indexDatabases":647,"url":648,"thumbnailPath":649,"statistic":650,"gsStatistic":26,"type":26,"analyzePriority":26},"19221551-7519-47ff-a892-331d1139c64b","2023-09-12T07:03:05.744+00:00","2026-01-24T20:54:40.144+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-S%E1%BB%A9c-kho%E1%BA%BB-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-Th%C3%A0nh-ph%E1%BB%91-H%E1%BB%93-Ch%C3%AD-Minh",{"country":579,"issn":580,"introduce":582,"title":584},{"VOID":15},{"VOID":581},"27349446",{"EN":583},"{\"ops\":[{\"attributes\":{\"bold\":true},\"insert\":\"1. History\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Science and Technology Development Journal\"},{\"insert\":\" (STDJ) (ISSN 2734-9446), Vietnam National University - Ho Chi Minh City (VNU-HCM) was established in 1997. And the first issue was published in January 1998 with ISSN 1859-0128. Since then, STDJ has become the most important scientific forum of scientists from VNU-HCM as well as other universities. The magazine has undergone 20 years of development and has become a bridge for scientific exchanges, as well as enriching reference materials for the faculty, doctoral students, students of VNU-HCM in particular and other universities, institutes...\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal since 2020.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\" \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"2. 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Elsevier",{"EN":681,"VI":683},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[686],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F31096","1980-2002,2004","SCOPUS__Q1",{"meta":691,"data":693},{"total":692},"32",[694,1059,1212,1439,1646,1736,1912,2126,2325,2531],{"id":695,"createTime":696,"updateTime":697,"relativeEntities":698,"slug":699,"properties":700,"entityType":717,"verifyStatus":25,"verifyTime":718,"verifyNote":719,"syncStatus":28,"languages":720,"translateLanguages":721,"viewCount":36,"primaryUrl":722,"fullTextUrl":26,"authors":723,"publicationType":838,"publisherRelationship":839,"citationCount":862,"citationInfo":863,"publishDate":865,"publishYear":866,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":867,"isForceReanalyzing":1058},"5045b948-d710-40c1-926b-cf02607fce84","2024-12-04T18:31:28.020+00:00","2024-12-24T15:34:11.307+00:00",[],"Features-of-apoptotic-cells-measured-by-flow-cytometry",{"mag":701,"keywords":703,"openalex":705,"abstract":707,"title":710,"pm":713,"doi":715},{"VOID":702},"2148911589",{"VI":704},"Apoptosis, necrosis, lưu lượng tế bào học, HL-60, tế bào tuyến ức, DNA topoizomeras, dấu hiệu sinh hóa, phân biệt tế bào chết, phương pháp phân định tế bào.",{"VOID":706},"W2148911589",{"EN":708,"VI":709},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The present review describes several methods to characterize and differentiate between two different mechanisms of cell death, apoptosis and necrosis. Most of these methods were applied to studies of apoptosis triggered in the human leukemic HL‐60 cell line by DNA topoisomerase I or II inhibitors, and in rat thymocytes by either topoisomerase inhibitors or prednisolone. In most cases, apoptosis was selective to cells in a particular phase of the cell cycle: only Sphase HL‐60 cells and G\u003Cjats:sub>0\u003C\u002Fjats:sub> thymocytes were mainly affected. Necrosis was induced by excessively high concentrations of these drugs. The following cell features were found useful to characterize the mode of cell death: (a) Activation of an endonuclease in apoptotic cells resulted in extraction of the low molecular weight DNA following cell permeabilization, which, in turn, led to their decreased stainability with DNA‐specific fluorochromes. Measurements of DNA content made it possible to identify apoptotic cells and to recognize the cell cycle phase specificity oaf the apoptotic process. (b) Plasma membrane integrity, which is lost in necrotic but not in apoptotic cells, was probed by the exclusion of propidium iodide (PI). The combination of PI followed by Hoechst 33342 proved to be an excellent probe to distinguish live, necrotic, early‐ and late‐apoptotic cells. (c) Mitochondrial transmembrane potential, assayed by retention of rhodamine 123 was preserved in apoptotic but not necrotic cells. (d) The ATP‐dependent lysosomal proton pump, tested by the supravital uptake of acridine orange (AO) was also preserved in apoptotic but not necrotic cells. (e) Bivariate analysis of cells stained for DNA and protein revealed markedly diminished protein content in apoptotic cells, most likely due to activation of endogenous proteases. Necrotic cells, having leaky membranes, had minimal protein content. (f) Staining of RNA allowed for the discrimination of G\u003Cjats:sub>0\u003C\u002Fjats:sub> from G\u003Cjats:sub>1\u003C\u002Fjats:sub> cells and thus made it possible to reveal that apoptosis was selective to G\u003Cjats:sub>0\u003C\u002Fjats:sub> thymocytes. (g) The decrease in forward light shatter, paralleled either by no change (HL‐60 cells) or an increase (thymocytes) of right angle scatter, were early changes during apoptosis. (h) The sensitivity of DNA in situ to denaturation, was increased in apoptotic and necrotic cells. This feature, probed by staining with AO at love pH, provided a sensitive and early assay to discriminate between live, apoptotic and necrotic cells, and to evaluate the cell cycle phase specificity of these processes. (i) The in situ nick translation assay employing labeled triphosphonucleotides can be used to reveal DNA strand breaks, to detect the very early stages of apoptosis. The data presented indicate that flow cytometry can be applied in basic research on molecular and biochemical mechanisms of apoptosis, as well as in the clinic, where the ability to monitor early signs of apoptosis in samples from patients' tumors may be predictive of the outcome of some treatment protocols. © 1992 Wiley‐Liss, Inc.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Bài tổng quan này mô tả nhiều phương pháp để nhận diện và phân biệt giữa hai cơ chế chết tế bào khác nhau, apoptosis và hoại tử. Đa phần các phương pháp này đã được áp dụng trong các nghiên cứu về apoptosis trong dòng tế bào bạch cầu HL-60 của người bị kích hoạt bởi các chất ức chế DNA topoizomeras I hoặc II, và trong các tế bào tuyến ức của chuột bởi cả chất ức chế topoizomeras hoặc prednisolone. Trong hầu hết các trường hợp, apoptosis chọn lọc đối với tế bào trong pha nhất định của chu kỳ tế bào: chỉ tế bào HL-60 pha S và tế bào tuyến ức G\u003Cjats:sub>0\u003C\u002Fjats:sub> bị ảnh hưởng chính. Hoại tử được kích hoạt bởi nồng độ quá cao của những loại thuốc này. Các đặc điểm tế bào sau đây đã được xác định có ích trong việc nhận diện kiểu chết tế bào: (a) Sự kích hoạt endonuclease trong tế bào apoptosis dẫn đến việc chiết xuất DNA có trọng lượng phân tử thấp sau khi tế bào bị thẩm thấu, dẫn đến giảm khả năng nhuộm bằng các fluoroquinone đặc hiệu với DNA. Đo hàm lượng DNA giúp nhận diện tế bào apoptosis và phát hiện được pha đặc hiệu của chu kỳ tế bào liên quan đến tiến trình apoptosis. (b) Tính toàn vẹn màng tế bào, mất trong tế bào hoại tử nhưng không mất trong tế bào apoptosis, đã được thăm dò bằng cách loại trừ iodua propidium (PI). Sự kết hợp giữa PI và Hoechst 33342 tỏ ra là một đầu dò tuyệt vời để phân biệt các tế bào sống, hoại tử, apoptosis sớm và muộn. (c) Điện thế xuyên màng ty thể, đo thông qua khả năng giữ rhodamine 123 được giữ nguyên trong tế bào apoptosis nhưng không trong tế bào hoại tử. (d) Bơm proton lysosome phụ thuộc vào ATP, thử nghiệm thông qua khả năng hút acridine orange (AO) trong môi trường sống, cũng được giữ nguyên trong tế bào apoptosis nhưng không trong tế bào hoại tử. (e) Phân tích bivariate của tế bào được nhuộm DNA và protein tiết lộ giảm đáng kể hàm lượng protein trong tế bào apoptosis, có lẽ do sự kích hoạt của protease nội sinh. Tế bào hoại tử, có màng bị rò, có hàm lượng protein tối thiểu. (f) Nhuộm RNA cho phép phân biệt giữa tế bào G\u003Cjats:sub>0\u003C\u002Fjats:sub> và G\u003Cjats:sub>1\u003C\u002Fjats:sub> và như vậy có thể chứng minh rằng apoptosis lựa chọn tế bào tuyến ức G\u003Cjats:sub>0\u003C\u002Fjats:sub>. (g) Sự giảm trong tán xạ ánh sáng phía trước, được đi kèm bởi hoặc không có thay đổi (tế bào HL-60) hoặc tăng (tế bào tuyến ức) của tán xạ góc phải, là những thay đổi sớm trong apoptosis. (h) Độ nhạy của DNA in situ đối với sự suy thoái, tăng trong tế bào apoptosis và tế bào hoại tử. Đặc điểm này, được thăm dò bằng cách nhuộm với AO ở pH thấp, cung cấp một thử nghiệm nhạy cảm và sớm để phân biệt giữa các tế bào sống, tế bào apoptosis và tế bào hoại tử, cũng như để đánh giá đặc điểm pha chu kỳ tế bào của các tiến trình này. (i) Phương pháp chuyển dịch nick in situ sử dụng triphospohonucloside gắn nhãn có thể được sử dụng để tiết lộ đứt gãy sợi DNA, để phát hiện giai đoạn rất sớm của apoptosis. Dữ liệu cho thấy rằng lưu lượng tế bào học có thể được áp dụng trong nghiên cứu cơ bản về cơ chế sinh hóa và phân tử của apoptosis, cũng như trong lâm sàng nơi khả năng theo dõi các dấu hiệu sớm của apoptosis trong các mẫu từ các khối u của bệnh nhân có thể dự đoán kết quả của một số phác đồ điều trị. © 1992 Wiley-Liss, Inc.\u003C\u002Fjats:p>",{"EN":711,"VI":712},"Features of apoptotic cells measured by flow cytometry","Đặc điểm của tế bào theo cơ chế apoptosis được đo bằng lưu lượng tế bào học",{"VOID":714},"1333943",{"VOID":716},"10.1002\u002Fcyto.990130802","PUBLICATION","2024-12-04T18:31:28.018+00:00","Auto Verify",[102],[101],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.990130802",[724,744,759,774,789,806,821],{"id":725,"sortIndex":135,"researcher":26,"roles":726,"affiliations":727,"properties":739},"72e53843-fb47-45c4-ae27-c5718d34f130",[],[728],{"id":729,"sortIndex":36,"affiliation":730,"properties":26},"8c19f39f-87a8-4ddc-9c9a-68752d1b1e70",{"id":731,"createTime":732,"updateTime":733,"relativeEntities":734,"slug":735,"properties":736,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"9fe352e2-f976-46dc-89a4-c86a49fe3348","2024-01-05T20:34:20.057+00:00","2024-12-04T18:31:28.055+00:00",[],"The-Cancer-Research-Institute-New-York-Medical-College-Valhalla-New-York-10595",{"title":737},{"VI":738},"The Cancer Research Institute, New York Medical College, Valhalla, New York, 10595",{"openalex":740,"title":742},{"VOID":741},"A5013493640",{"EN":743},"Frank Traganos",{"id":745,"sortIndex":59,"researcher":26,"roles":746,"affiliations":747,"properties":754},"8500c70f-4371-46fc-9bcb-d9f5cc5e8034",[],[748],{"id":749,"sortIndex":36,"affiliation":750,"properties":26},"f0d22ca6-fb7f-4a2d-bbd0-17d92754b305",{"id":731,"createTime":732,"updateTime":733,"relativeEntities":751,"slug":735,"properties":752,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":753},{"VI":738},{"openalex":755,"title":757},{"VOID":756},"A5009873745",{"EN":758},"Wojciech Gorczyca",{"id":760,"sortIndex":111,"researcher":26,"roles":761,"affiliations":762,"properties":769},"8b0f64d2-5410-4c79-9842-cc8bd76456f6",[],[763],{"id":764,"sortIndex":36,"affiliation":765,"properties":26},"f80b92d2-7d63-4ae0-a0fe-ef4b2b026276",{"id":731,"createTime":732,"updateTime":733,"relativeEntities":766,"slug":735,"properties":767,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":768},{"VI":738},{"openalex":770,"title":772},{"VOID":771},"A5108591198",{"EN":773},"Michel A. 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Curr. Commun. Cell & Mol. Biol., 157",{},{"id":26,"text":893,"url":26,"identifiers":894},"10.1210\u002Fmend-2-7-650",{"doi":893},{"id":26,"text":896,"url":26,"identifiers":897},"10.1210\u002Fendo-122-5-2158",{"doi":896},{"id":26,"text":899,"url":26,"identifiers":900},"10.1007\u002FBF00496774",{"doi":899},{"id":26,"text":902,"url":26,"identifiers":903},"Darzynkiewicz Z, 1990, Flow Cytometry and Sorting, 315",{},{"id":26,"text":905,"url":26,"identifiers":906},"Darzynkiewicz Z, 1990, Flow Cytometry and Sorting, 291",{},{"id":26,"text":908,"url":26,"identifiers":909},"10.1002\u002Fcyto.990080206",{"doi":908},{"id":26,"text":911,"url":26,"identifiers":912},"10.1073\u002Fpnas.78.4.2383",{"doi":911},{"id":26,"text":914,"url":26,"identifiers":915},"Darzynkiewicz Z, 1990, Flow Cytometry and Sorting, 469",{},{"id":26,"text":917,"url":26,"identifiers":918},"10.1002\u002Fcyto.990050411",{"doi":917},{"id":26,"text":920,"url":26,"identifiers":921},"10.1073\u002Fpnas.73.8.2881",{"doi":920},{"id":26,"text":923,"url":26,"identifiers":924},"Darzynkiewicz Z, 1984, Cell cyclespecific effects of tumor necrosis factor, Cancer Res, 44, 83",{},{"id":26,"text":926,"url":26,"identifiers":927},"Del BinoG BrunoS YiPN DarzynkiewiczZ: Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation.Cell Prolif(in press).",{},{"id":26,"text":929,"url":26,"identifiers":930},"DelBino G, 1991, Camptothecin, teniposide or 4'(9‐acridinylamino)‐3‐methane‐sulfon‐m‐anisidide but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in S phase of HL‐60 cells, Cancer Res, 51, 1165",{},{"id":26,"text":932,"url":26,"identifiers":933},"10.1016\u002F0014-4827(91)90534-2",{"doi":932},{"id":26,"text":935,"url":26,"identifiers":936},"DelBino G, 1990, Diverse effects of camptothecin, an inhibitor of topoisomerase I on the cell cycle of lymphocytic (L1210, MOLT‐4) and myelogenous (HL‐60, KGl)leukemia cells, Cancer Res, 50, 5746",{},{"id":26,"text":938,"url":26,"identifiers":939},"10.1016\u002F0014-4827(91)90400-O",{"doi":938},{"id":26,"text":941,"url":26,"identifiers":942},"10.1038\u002Fbjc.1991.269",{"doi":941},{"id":26,"text":944,"url":26,"identifiers":945},"10.1016\u002F0167-4889(92)90048-G",{"doi":944},{"id":26,"text":947,"url":26,"identifiers":948},"Duke RC, 1991, Apoptosis:The Molecular Basis of Cell Death. Curr. Commun. Cell & Mol. Biol., 209",{},{"id":26,"text":950,"url":26,"identifiers":951},"10.1016\u002F0092-8674(92)90123-T",{"doi":950},{"id":26,"text":953,"url":26,"identifiers":954},"10.1002\u002Fcyto.990070107",{"doi":953},{"id":26,"text":956,"url":26,"identifiers":957},"10.3181\u002F00379727-174-41731",{"doi":956},{"id":26,"text":959,"url":26,"identifiers":960},"Hotz MA, 1992, Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL‐60 and lymphocytic MOLT‐4 cells, Cancer Res, 52, 1530",{},{"id":26,"text":962,"url":26,"identifiers":963},"10.1016\u002F0014-4827(92)90362-C",{"doi":962},{"id":26,"text":965,"url":26,"identifiers":966},"10.1073\u002Fpnas.77.2.990",{"doi":965},{"id":26,"text":968,"url":26,"identifiers":969},"Jonker RR, 1992, NATO Advanced Study Institutes Programme. New Developments in Flow Cytometry, 30",{},{"id":26,"text":971,"url":26,"identifiers":972},"Kaufmann SH, 1989, Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs. A cautionary note, Cancer Res, 49, 5870",{},{"id":26,"text":974,"url":26,"identifiers":975},"Kerr JFR, 1991, Apoptosis: The Molecular Basis of Cell Death. Curr. Commun. Cell & Mot. Biol., 5",{},{"id":26,"text":977,"url":26,"identifiers":978},"10.1002\u002Fpath.1711050103",{"doi":977},{"id":26,"text":980,"url":26,"identifiers":981},"Krishan A, 1975, Morphological basis for the cytolytic effect of Vinblastine and Vincristine on cultured human leukemic lymphocytes, Cancer Res, 35, 497",{},{"id":26,"text":983,"url":26,"identifiers":984},"10.1002\u002Fcyto.990110309",{"doi":983},{"id":26,"text":986,"url":26,"identifiers":987},"10.1111\u002Fj.1365-2184.1991.tb01150.x",{"doi":986},{"id":26,"text":989,"url":26,"identifiers":990},"Lockshin RA, 1991, Apoptosis: The Molecular Basis of Cell Death. Curr. Common. Cell & Mol. Biol., 47",{},{"id":26,"text":992,"url":26,"identifiers":993},"Martin DP, 1991, Apoptosis: The Molecular Basis of Cell Death. Curr. Common. Cell & Mol. Biol., 247",{},{"id":26,"text":995,"url":26,"identifiers":996},"McConkey DJ, 1991, Apoptosis: The Molecular Basis of Cell Death. Curr. Common. Cell & Mol. Biol., 227",{},{"id":26,"text":998,"url":26,"identifiers":999},"10.1016\u002F0008-8749(90)90106-2",{"doi":998},{"id":26,"text":1001,"url":26,"identifiers":1002},"Pollack A, 1991, Flow Cytometry, 19",{},{"id":26,"text":1004,"url":26,"identifiers":1005},"Schrek R, Two types of interphase death of lymphocytes exposed to temperatures of 37–45°C, Radiat Res, 82, 162, 10.2307\u002F3575245",{"doi":1006},"10.2307\u002F3575245",{"id":26,"text":1008,"url":26,"identifiers":1009},"Server AC, 1991, Apoptosis: The Molecular Basis of Cell Death. Curr. Common. Cell & Mol. Biol., 263",{},{"id":26,"text":1011,"url":26,"identifiers":1012},"10.1002\u002Fcyto.990020302",{"doi":1011},{"id":26,"text":1014,"url":26,"identifiers":1015},"10.1016\u002F0022-1759(91)90396-W",{"doi":1014},{"id":26,"text":1017,"url":26,"identifiers":1018},"10.1073\u002Fpnas.86.5.1643",{"doi":1017},{"id":26,"text":1020,"url":26,"identifiers":1021},"10.1002\u002Fcyto.990130205",{"doi":1020},{"id":26,"text":1023,"url":26,"identifiers":1024},"10.1111\u002Fj.1365-2184.1991.tb01173.x",{"doi":1023},{"id":26,"text":1026,"url":26,"identifiers":1027},"Tomei LD, 1991, Apoptosis: The Molecular Basis of Cell Death. Curr. Commun. Cell and Mol. Biol.",{},{"id":26,"text":1029,"url":26,"identifiers":1030},"TraganosF ArdeltB HalkoN BrunoS DarzynkiewiczZ: Effects of Genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT‐4 and HL‐60 cells.Cancer Res(in press).",{},{"id":26,"text":1032,"url":26,"identifiers":1033},"Tritton TR, 1991, Apoptosis: The Molecular Basis of Cell Death. Curr. Commun. Cell and Mol. 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The attainment of low coefficients of variation of the peaks and of quantitative staining of nuclei from different tissues was a problem with the original method. This was solved in the new modification by trypsinization of the unfixed nuclei. The nuclei were stabilized by spermine. A simple procedure for long‐term storage of samples at —80°C was integrated into the method. The fluorescence of the nuclei was stable for at least 3 hours after staining. Light exposure protection of the samples was essential. No cell loss was caused by storage or staining. The method was successfully applied on samples including: (\u003Cjats:italic>a\u003C\u002Fjats:italic>) Normal tissues— human lymphocytes, granulocytes and spleen. Mouse lymphocytes, bone marrow, spleen, liver, kidney and thymus. (\u003Cjats:italic>b\u003C\u002Fjats:italic>) Human neoplasms— lung cancer, breast cancer, lymphoma, leukemia, bladder cancer and cancer of the oral cavity. (\u003Cjats:italic>c\u003C\u002Fjats:italic>) Human tumors in nude mice— breast cancer, lung cancer, melanoma and colon cancer. (\u003Cjats:italic>d\u003C\u002Fjats:italic>) Mouse ascites tumors— JB‐1, L 1210, Ehrlich and P 383. It therefore seems well suited as a routine clinical procedure.\u003C\u002Fjats:p>",{"EN":1073},"A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis",{"VOID":1075},"6188586",{"VOID":1077},"10.1002\u002Fcyto.990030503",[102],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.990030503",[1081,1100,1115],{"id":1082,"sortIndex":114,"researcher":26,"roles":1083,"affiliations":1084,"properties":1095},"301f9e68-0b4d-4b5a-b4e7-f6124e7c2a9e",[],[1085],{"id":1086,"sortIndex":36,"affiliation":1087,"properties":26},"0079f8ee-cd24-4cff-b190-d2201835f980",{"id":1088,"createTime":1089,"updateTime":1089,"relativeEntities":1090,"slug":1091,"properties":1092,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"0cbdc641-f795-4311-88a3-1673c3117ab1","2024-10-14T04:08:49.734+00:00",[],"Department-of-Internal-Medicine-The-Finsen-Institute-49-Strandboulevarden-DK-2100-Copenhagen-Denmark",{"title":1093},{"EN":1094},"Department of Internal Medicine, The Finsen Institute, 49, Strandboulevarden, DK‐2100 Copenhagen, Denmark",{"openalex":1096,"title":1098},{"VOID":1097},"A5019807812",{"EN":1099},"Nis I. 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LL, 1977, Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions, Virchows Arch (Cell Pathol), 24, 227, 10.1007\u002FBF02889282",{"doi":1193},"10.1007\u002FBF02889282",{"id":26,"text":1195,"url":26,"identifiers":1196},"10.1002\u002Fcyto.990030505",{"doi":1195},{"id":26,"text":1198,"url":26,"identifiers":1199},"10.1002\u002Fcyto.990030502",{"doi":1198},{"id":26,"text":1201,"url":26,"identifiers":1202},"10.1002\u002Fcyto.990030504",{"doi":1201},{"id":26,"text":1204,"url":26,"identifiers":1205},"Vindeløv LL, 1982, Treatment of small‐cell carcinoma of the lung monitored by sequential flow cytometric DNA analysis, Cancer Res, 42, 2499",{},{"id":26,"text":1207,"url":26,"identifiers":1208},"Vindeløv LL, 1980, Clonal heterogeneity of small‐cell anaplastic carcinoma of the lung demonstrated by flowcytometric DNA analysis, Cancer Res, 40, 4295",{},{"id":26,"text":1210,"url":26,"identifiers":1211},"Zante J, 1976, Pulse‐Cytophotometry, 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of nonviable cells in immunofluorescently stained cell populations is essential for obtaining accurate data. Fluorescent non‐vital DNA dyes, particularly propidium iodide (PI), have been used routinely in flow cytometry for discrimination of dead cells from viable cells on the basis of fluorescence. We describe here the use of an alternative DNA dye, 7‐amino‐actinomycin D (7‐AAD), which can replace PI for the exclusion of nonviable cells. As an example, we present in this paper the utilization of 7‐AAD on various leukemic cell lines for dead cell exclusion whenever the viable cell population could not be discriminated reliably from nonviable cells on the light scatter histogram; 7‐AAD is suitable for dead cell discrimination in lengthy experiments because it is efficiently excluded by intact cells and has a high DNA binding constant. In addition, the dye is valuable in combination with phycoerythrin (PE)‐fluorescence dual‐color flow cytometry on a single argon laser instrument, since its emission in the far red can easily be separated from the emission of PE; 7‐AAD was used on fluoresceinisothiocyanate (FITC) and PE surface‐labeled human thymocytes for characterization of the dying subpopulation of cells which is undergoing programmed cell death. In this heterogeneous cell preparation, the spectral properties of the dye permitted the classification of viable and nonviable cell subpopulations by multiparameter analysis.\u003C\u002Fjats:p>",{"EN":1226},"Dead cell discrimination with 7‐amino‐actinomcin D in combination with dual color immunofluorescence in single laser flow cytometry",{"VOID":1228},"1547670",{"VOID":1230},"10.1002\u002Fcyto.990130216",[102],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.990130216",[1234,1265,1285,1306,1334],{"id":1235,"sortIndex":111,"researcher":26,"roles":1236,"affiliations":1237,"properties":1260},"a7a66359-4779-4f19-b432-142bce9d05fa",[],[1238,1249],{"id":1239,"sortIndex":115,"affiliation":1240,"properties":26},"9cbc091b-a011-4c08-851a-5d8032c3c2c1",{"id":1241,"createTime":1242,"updateTime":1243,"relativeEntities":1244,"slug":1245,"properties":1246,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2127d848-db25-4079-8b95-2a1c6f8f0481","2024-10-07T21:31:54.513+00:00","2025-01-03T10:13:18.770+00:00",[],"Jonsson-Comprehensive-Cancer-Center-UCLA-School-of-Medicine-Los-Angeles-California-90024",{"title":1247},{"EN":1248},"Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90024",{"id":1250,"sortIndex":36,"affiliation":1251,"properties":26},"46452b95-09ec-484b-99fd-3fcf73e9ddf6",{"id":1252,"createTime":1253,"updateTime":1254,"relativeEntities":1255,"slug":1256,"properties":1257,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"7079bedd-530d-447c-8eff-9dbd2867712b","2024-01-20T23:52:28.116+00:00","2025-01-05T10:42:12.946+00:00",[],"Department-of-Medicine-UCLA-School-of-Medicine-Los-Angeles-California-90024",{"title":1258},{"VI":1259},"Department of Medicine, UCLA School of Medicine, Los Angeles, California 90024",{"openalex":1261,"title":1263},{"VOID":1262},"A5006167659",{"EN":1264},"Janis V. 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JED, 1990, Fluorescent dyes for studying cell death, App Fluores Technol, 2, 1",{},{"id":26,"text":1403,"url":26,"identifiers":1404},"10.1177\u002F23.11.1194669",{"doi":1403},{"id":26,"text":1406,"url":26,"identifiers":1407},"10.1111\u002Fj.1749-6632.1975.tb29166.x",{"doi":1406},{"id":26,"text":1409,"url":26,"identifiers":1410},"10.1016\u002FS0022-2836(68)80024-5",{"doi":1409},{"id":26,"text":1412,"url":26,"identifiers":1413},"Rabinovitch PS, 1986, Simultaneous cell cycle analysis and two‐color surface immunofluorescence using 7‐amino‐actinomycin D and single laser excitation: Applications to study of cell activation and the cell cycle of murine Ly‐1 B cells, J Immunol, 36, 2769, 10.4049\u002Fjimmunol.136.8.2769",{"doi":1414},"10.4049\u002Fjimmunol.136.8.2769",{"id":26,"text":1416,"url":26,"identifiers":1417},"Robinson JP, 1990, Handbook of Flow Cytometry Methods, 25",{},{"id":26,"text":1419,"url":26,"identifiers":1420},"10.1002\u002Fcyto.990080411",{"doi":1419},{"id":26,"text":1422,"url":26,"identifiers":1423},"10.1002\u002Fcyto.990120312",{"doi":1422},{"id":26,"text":1425,"url":26,"identifiers":1426},"Shapiro HM, 1988, Practical Flow Cytometry, 168",{},{"id":26,"text":1428,"url":26,"identifiers":1429},"Stewart GC, 1990, Methods of Cell Biology 33, Flow Cytometry, 449",{},{"id":26,"text":1431,"url":26,"identifiers":1432},"10.1038\u002F351150a0",{"doi":1431},{"id":26,"text":1434,"url":26,"identifiers":1435},"10.1093\u002Fintimm\u002F2.12.1179",{"doi":1434},{"id":26,"text":1437,"url":26,"identifiers":1438},"10.1002\u002Fcyto.990050410",{"doi":1437},{"id":1440,"createTime":1441,"updateTime":1441,"relativeEntities":1442,"slug":1443,"properties":1444,"entityType":717,"verifyStatus":25,"verifyTime":1458,"verifyNote":719,"syncStatus":28,"languages":1459,"translateLanguages":26,"viewCount":36,"primaryUrl":1460,"fullTextUrl":26,"authors":1461,"publicationType":838,"publisherRelationship":1511,"citationCount":1534,"citationInfo":1535,"publishDate":1537,"publishYear":1538,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1539,"isForceReanalyzing":1058},"79413e21-eebe-4e95-b9cb-430dcb94764e","2025-02-06T23:52:49.943+00:00",[],"Mitochondrial-and-nonmitochondrial-reduction-of-MTT-Interaction-of-MTT-with-TMRE-JC-1-and-NAO-mitochondrial-fluorescent-probes",{"mag":1445,"keywords":1447,"openalex":1448,"abstract":1450,"title":1452,"pm":1454,"doi":1456},{"VOID":1446},"2061449630",{},{"VOID":1449},"W2061449630",{"EN":1451},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>Bioreduction of water‐soluble tetrazolium salts (e.g., MTS, XTT, and MTT) to their respective formazans is generally regarded as an indicator of cell “redox activity.” The reaction is attributed mainly to mitochondrial enzymes and electron carriers. However, MTT reduction may also be catalyzed by a number of other nonmitochondrial enzymes. The goal of this work was to establish the sites of MTT reduction in intact HepG2 human hepatoma cells in culture.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>In order to establish the subcellular localization of the sites of reduction of MTT, we imaged the formation of MTT‐formazan deposits using backscattered light confocal microscopy. Mitochondria were visualized in viable cells using fluorescent dyes that bind in a manner dependent (JC‐1 and TMRE) or independent (NAO) of mitochondrial electric potential.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Only 25–45% of MTT‐formazan was associated with mitochondria after 25 min of incubation. No more than 25% of the mitochondrial area on images was occupied by MTT‐formazan. Mitochondrial fluorescence of TMRE, NAO, and the monomeric form of JC‐1 decreased rapidly in cells incubated with MTT. However, the intensity of fluorescence of JC‐1 aggregates dropped by less than 30% at the onset of incubation and remained constant as reduction of MTT proceeded further.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>(1) Most of MTT‐formazan deposits are not coincident with mitochondria. (2) Monomeric JC‐1, as well as TMRE and NAO, accumulating in mitochondria may be displaced by MTT. Thus, the presence of positively charged organic compounds (like MTT) may distort measurements of mitochondrial transmembrane electric potential, which are based on accumulation of fluorescent dyes. Cytometry 47:236–242, 2002. © 2002 Wiley‐Liss, Inc.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1453},"Mitochondrial and nonmitochondrial reduction of MTT: Interaction of MTT with TMRE, JC‐1, and NAO mitochondrial fluorescent probes",{"VOID":1455},"11933013",{"VOID":1457},"10.1002\u002Fcyto.10080","2025-02-06T23:52:49.942+00:00",[102],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.10080",[1462,1483],{"id":1463,"sortIndex":115,"researcher":26,"roles":1464,"affiliations":1465,"properties":1476},"f24f9102-2bbc-49a6-b5de-bf93813d072c",[],[1466],{"id":1467,"sortIndex":36,"affiliation":1468,"properties":26},"a78455f9-a073-4022-9b99-22a9a49351c0",{"id":1469,"createTime":1470,"updateTime":1470,"relativeEntities":1471,"slug":1472,"properties":1473,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e1b42c0e-419c-4705-866f-7dad512ff054","2025-02-06T23:52:49.961+00:00",[],"Laboratory-of-Confocal-Microscopy-and-Image-Analysis-Department-of-Biophysics-Institute-of-Molecular-Biology-and-Biotechnology-Jagiellonian-University-Krakow-Poland",{"title":1474},{"EN":1475},"Laboratory of Confocal Microscopy and Image Analysis, Department of Biophysics, Institute of Molecular Biology and Biotechnology, Jagiellonian University, Krakow, Poland",{"openalex":1477,"orcid":1479,"title":1481},{"VOID":1478},"A5002046870",{"VOID":1480},"https:\u002F\u002Forcid.org\u002F0000-0002-4432-1522",{"EN":1482},"Jurek Dobrucki",{"id":1484,"sortIndex":36,"researcher":26,"roles":1485,"affiliations":1486,"properties":1504},"4a939f3e-482f-40ce-ab2f-e78add67ce56",[],[1487,1498],{"id":1488,"sortIndex":36,"affiliation":1489,"properties":26},"4d77cb94-675b-447c-8ccb-a1777402a67d",{"id":1490,"createTime":1491,"updateTime":1492,"relativeEntities":1493,"slug":1494,"properties":1495,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"18dd32f5-7b1c-49ae-97fa-58a87356305f","2023-12-23T17:03:29.911+00:00","2025-02-06T23:52:49.958+00:00",[],"Department-of-Plant-Anatomy-and-Cytology-University-of-Silesia-Katowice-Poland",{"title":1496},{"VI":1497},"Department of Plant Anatomy and Cytology, University of Silesia, Katowice, Poland",{"id":1499,"sortIndex":115,"affiliation":1500,"properties":26},"5ebfcb1e-1a55-4df7-8c76-06326bded3b8",{"id":1469,"createTime":1470,"updateTime":1470,"relativeEntities":1501,"slug":1472,"properties":1502,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1503},{"EN":1475},{"openalex":1505,"orcid":1507,"title":1509},{"VOID":1506},"A5082011854",{"VOID":1508},"https:\u002F\u002Forcid.org\u002F0000-0003-0841-5940",{"EN":1510},"Tytus Bernaś",{"url":26,"publisher":1512,"properties":1527},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1513,"slug":663,"properties":1514,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1518,"manageAffiliations":1519,"indexDatabases":1520,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1515,"eissn":1516,"title":1517},{"VOID":666},{"VOID":668},{"EN":663},[],[],[1521],{"id":674,"indexDatabase":1522,"url":687,"indexYears":688,"academicFieldIds":26,"indexDatabaseRanking":689},{"id":676,"createTime":677,"updateTime":678,"relativeEntities":1523,"label":1524,"description":1525,"key":684,"publicationTags":1526,"standard":26},[],{"EN":681,"VI":681},{"EN":681,"VI":683},[686],{"volume":1528,"pages":1530,"issue":1532},{"VOID":1529},"47",{"VOID":1531},"236-242",{"VOID":1533},"4",311,{"total":1534,"publishYear":26,"statisticByYear":1536},{"2012":239,"2013":237,"2014":234,"2015":356,"2016":516,"2017":124,"2018":234,"2019":336,"2020":222,"2021":336,"2022":356,"2023":53,"2024":111,"2025":115},"2002-04-01",2002,[1540,1543,1546,1549,1552,1555,1558,1561,1564,1567,1570,1573,1576,1580,1583,1585,1588,1591,1594,1597,1600,1603,1606,1609,1612,1615,1618,1621,1624,1627,1630,1633,1637,1640,1643],{"id":26,"text":1541,"url":26,"identifiers":1542},"10.1177\u002F38.1.2104633",{"doi":1541},{"id":26,"text":1544,"url":26,"identifiers":1545},"Dikov A, 1999, New tetrazolium method for the histochemical demonstration of gamma‐glutamyl transpeptidase, Cell Mol Biol, 45, 241",{},{"id":26,"text":1547,"url":26,"identifiers":1548},"10.1007\u002FBF01273359",{"doi":1547},{"id":26,"text":1550,"url":26,"identifiers":1551},"10.1016\u002F0024-3205(96)00427-4",{"doi":1550},{"id":26,"text":1553,"url":26,"identifiers":1554},"10.1016\u002FS0143-4179(96)90079-7",{"doi":1553},{"id":26,"text":1556,"url":26,"identifiers":1557},"Scudiero DA, 1988, Evaluation of a soluble tetrazolium\u002Fformazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines, Cancer Res, 48, 4827",{},{"id":26,"text":1559,"url":26,"identifiers":1560},"Marshall NJ, 1995, A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function, Growth Regul, 5, 69",{},{"id":26,"text":1562,"url":26,"identifiers":1563},"10.1046\u002Fj.1471-4159.1995.65062585.x",{"doi":1562},{"id":26,"text":1565,"url":26,"identifiers":1566},"10.1002\u002F(SICI)1097-4547(19980201)51:3\u003C360::AID-JNR9>3.0.CO;2-E",{"doi":1565},{"id":26,"text":1568,"url":26,"identifiers":1569},"10.1006\u002Fabbi.1993.1311",{"doi":1568},{"id":26,"text":1571,"url":26,"identifiers":1572},"10.1006\u002Fbbrc.1996.1453",{"doi":1571},{"id":26,"text":1574,"url":26,"identifiers":1575},"10.1006\u002Fabbi.2000.1907",{"doi":1574},{"id":26,"text":1577,"url":26,"identifiers":1578},"Green TR, 1990, Detection and isolation of the NADPH‐binding protein of the NADPH:O2 oxidoreductase complex of human neutrophils, J Biol Chem, 265, 19324, 10.1016\u002FS0021-9258(17)30661-0",{"doi":1579},"10.1016\u002FS0021-9258(17)30661-0",{"id":26,"text":1581,"url":26,"identifiers":1582},"10.1016\u002F0167-4838(90)90085-T",{"doi":1581},{"id":26,"text":1571,"url":26,"identifiers":1584},{"doi":1571},{"id":26,"text":1586,"url":26,"identifiers":1587},"10.1042\u002Fbst023056s",{"doi":1586},{"id":26,"text":1589,"url":26,"identifiers":1590},"10.1016\u002FS0006-3495(89)82743-2",{"doi":1589},{"id":26,"text":1592,"url":26,"identifiers":1593},"10.1016\u002FS0006-3495(89)82754-7",{"doi":1592},{"id":26,"text":1595,"url":26,"identifiers":1596},"10.1016\u002FS0006-3495(93)81318-3",{"doi":1595},{"id":26,"text":1598,"url":26,"identifiers":1599},"10.1016\u002FS0006-3495(99)77214-0",{"doi":1598},{"id":26,"text":1601,"url":26,"identifiers":1602},"10.1073\u002Fpnas.88.9.3671",{"doi":1601},{"id":26,"text":1604,"url":26,"identifiers":1605},"10.1111\u002Fj.1432-1033.1995.0113o.x",{"doi":1604},{"id":26,"text":1607,"url":26,"identifiers":1608},"10.1016\u002FS0014-5793(00)01861-5",{"doi":1607},{"id":26,"text":1610,"url":26,"identifiers":1611},"10.1016\u002F0014-4827(90)90219-Z",{"doi":1610},{"id":26,"text":1613,"url":26,"identifiers":1614},"10.1111\u002Fj.1365-2818.1993.tb03313.x",{"doi":1613},{"id":26,"text":1616,"url":26,"identifiers":1617},"10.1021\u002Fbi00232a015",{"doi":1616},{"id":26,"text":1619,"url":26,"identifiers":1620},"10.1016\u002F0006-291X(89)91700-2",{"doi":1619},{"id":26,"text":1622,"url":26,"identifiers":1623},"10.1046\u002Fj.1471-4159.1997.69020581.x",{"doi":1622},{"id":26,"text":1625,"url":26,"identifiers":1626},"10.1007\u002FBF01870205",{"doi":1625},{"id":26,"text":1628,"url":26,"identifiers":1629},"10.1021\u002Fbi00713a022",{"doi":1628},{"id":26,"text":1631,"url":26,"identifiers":1632},"10.1016\u002F0005-2728(84)90140-3",{"doi":1631},{"id":26,"text":1634,"url":26,"identifiers":1635},"Robertson DE, 1983, Membrane potential and surface potential in mitochondria. Fluorescence and binding of 1‐anilinonaphthalene‐8‐sulfonate, J Biol Chem, 258, 11039, 10.1016\u002FS0021-9258(17)44383-3",{"doi":1636},"10.1016\u002FS0021-9258(17)44383-3",{"id":26,"text":1638,"url":26,"identifiers":1639},"10.1016\u002F0005-2728(83)90217-7",{"doi":1638},{"id":26,"text":1641,"url":26,"identifiers":1642},"10.1016\u002FS0079-6336(76)80015-0",{"doi":1641},{"id":26,"text":1644,"url":26,"identifiers":1645},"10.1111\u002Fj.1432-1033.1992.tb17285.x",{"doi":1644},{"id":1647,"createTime":1648,"updateTime":1648,"relativeEntities":1649,"slug":1650,"properties":1651,"entityType":717,"verifyStatus":25,"verifyTime":1648,"verifyNote":719,"syncStatus":28,"languages":1665,"translateLanguages":26,"viewCount":36,"primaryUrl":1666,"fullTextUrl":26,"authors":1667,"publicationType":838,"publisherRelationship":1687,"citationCount":1710,"citationInfo":1711,"publishDate":1713,"publishYear":1714,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1715,"isForceReanalyzing":1058},"1b6feec5-8a47-4c59-8a79-340ef656ecbf","2024-09-26T10:50:30.262+00:00",[],"Modified-histogram-subtraction-technique-for-analysis-of-flow-cytometry-data",{"mag":1652,"keywords":1654,"openalex":1655,"abstract":1657,"title":1659,"pm":1661,"doi":1663},{"VOID":1653},"2118160968",{},{"VOID":1656},"W2118160968",{"EN":1658},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Analysis of flow cytometry histogram data by the subjective selection of an integration window can be a tedious and time‐consuming task and is often inaccurate. A new method for automated calculation of the percent positive from immunofluorescence histograms is presented. This new method is a modification of the currently used method of channel‐by‐channel histogram subtraction. Its accuracy is compared to that of the channel‐by‐channel histogram subtraction method and to another currently used automated method, which selects an integration window by finding the channels that contain the most fluorescent 2% of a control histogram.\u003C\u002Fjats:p>\u003Cjats:p>The new histogram subtraction method is objective, easy to use, and is more accurate than other currently used automated analysis methods. PASCAL source code is given for each method of analysis.\u003C\u002Fjats:p>",{"EN":1660},"Modified histogram subtraction technique for analysis of flow cytometry data",{"VOID":1662},"3061754",{"VOID":1664},"10.1002\u002Fcyto.990090617",[102],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.990090617",[1668],{"id":1669,"sortIndex":36,"researcher":26,"roles":1670,"affiliations":1671,"properties":1682},"9a37cc72-9a02-40a5-b267-5aaea122f27f",[],[1672],{"id":1673,"sortIndex":36,"affiliation":1674,"properties":26},"9f949d8c-6678-401c-9a76-6f538f23ed35",{"id":1675,"createTime":1676,"updateTime":1676,"relativeEntities":1677,"slug":1678,"properties":1679,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e80990fa-c617-47f9-892b-32e9c19eefde","2024-09-26T10:50:30.280+00:00",[],"Clinical-Immunology-Services-Program-Resources-Inc-Frederick-Cancer-Research-Facility-Maryland-21701-",{"title":1680},{"EN":1681},"Clinical Immunology Services, Program Resources, Inc., Frederick Cancer Research Facility, Maryland 21701.",{"openalex":1683,"title":1685},{"VOID":1684},"A5052886428",{"EN":1686},"W. Roy Overton",{"url":26,"publisher":1688,"properties":1703},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1689,"slug":663,"properties":1690,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1694,"manageAffiliations":1695,"indexDatabases":1696,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1691,"eissn":1692,"title":1693},{"VOID":666},{"VOID":668},{"EN":663},[],[],[1697],{"id":674,"indexDatabase":1698,"url":687,"indexYears":688,"academicFieldIds":26,"indexDatabaseRanking":689},{"id":676,"createTime":677,"updateTime":678,"relativeEntities":1699,"label":1700,"description":1701,"key":684,"publicationTags":1702,"standard":26},[],{"EN":681,"VI":681},{"EN":681,"VI":683},[686],{"volume":1704,"pages":1706,"issue":1708},{"VOID":1705},"9",{"VOID":1707},"619-626",{"VOID":1709},"6",248,{"total":1710,"publishYear":26,"statisticByYear":1712},{"2012":52,"2013":158,"2014":135,"2015":103,"2016":162,"2017":116,"2018":135,"2019":50,"2020":114,"2021":158,"2022":135,"2023":162,"2024":162},"1988-11-01",1988,[1716,1719,1723,1726,1730,1733],{"id":26,"text":1717,"url":26,"identifiers":1718},"10.1109\u002FPROC.1969.7447",{"doi":1717},{"id":26,"text":1720,"url":26,"identifiers":1721},"Loar LD, 1986, Production and characterization of monoclonal antibodies to rabbit lymphocyte subpopulations; I. Tissue immunofluorescence and flow cytometric analysis, J Immunol, 137, 2784, 10.4049\u002Fjimmunol.137.9.2784",{"doi":1722},"10.4049\u002Fjimmunol.137.9.2784",{"id":26,"text":1724,"url":26,"identifiers":1725},"10.1002\u002Fcyto.990040111",{"doi":1724},{"id":26,"text":1727,"url":26,"identifiers":1728},"Scher I, 1980, Development of B lymphocytes in the mouse; studies of frequency and distribution of surface IgM and IgD in normal and immune‐defective CBA\u002FN F1 mice, J Immunol, 125, 1686, 10.4049\u002Fjimmunol.125.4.1686",{"doi":1729},"10.4049\u002Fjimmunol.125.4.1686",{"id":26,"text":1731,"url":26,"identifiers":1732},"10.1177\u002F28.2.7354211",{"doi":1731},{"id":26,"text":1734,"url":26,"identifiers":1735},"10.1007\u002FBF00915224",{"doi":1734},{"id":1737,"createTime":1738,"updateTime":1738,"relativeEntities":1739,"slug":1740,"properties":1741,"entityType":717,"verifyStatus":25,"verifyTime":1738,"verifyNote":719,"syncStatus":28,"languages":1755,"translateLanguages":26,"viewCount":36,"primaryUrl":1756,"fullTextUrl":26,"authors":1757,"publicationType":838,"publisherRelationship":1823,"citationCount":1846,"citationInfo":1847,"publishDate":1849,"publishYear":1850,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1851,"isForceReanalyzing":1058},"253086f5-aeb8-47d6-a54f-0c9c282fa64e","2024-10-07T21:31:54.501+00:00",[],"Sensitive-method-for-measuring-apoptosis-and-cell-surface-phenotype-in-human-thymocytes-by-flow-cytometry",{"mag":1742,"keywords":1744,"openalex":1745,"abstract":1747,"title":1749,"pm":1751,"doi":1753},{"VOID":1743},"1992441650",{},{"VOID":1746},"W1992441650",{"EN":1748},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>A rapid, gentle, and sensitive method for quantification of cells undergoing apoptosis is presented. The method allows the simultaneous determination of dual‐color cell surface immunofluorescence. Cells are stained for 7 min with the vital dye Hoechst 33342 (HO342) for identification of live and apoptotic cells. 7‐amino‐actinomycin D (7‐AAD) is added to distinguish cells that have lost membrane integrity from apoptotic and live cells. Due to its spectral properties 7‐AAD can be utilized on cells that are dual‐surface labelled with fluoresceinisothiocyanate (FITC) and phycoerythrin (PE). The value of the method is demonstrated on human thymocytes, which constitutively undergo programmed cell death and which show an increase in the rate of apoptosis after exposure to the glucocorticoid dexamethasone (DEX). Vital staining with HO342 permits earlier detection of apoptotic changes compared to a staining technique in which cells are treated with a hypotonic citrate solution containing propidium iodide (PI) and the apoptotic cells are represented in a hypodiploid, “sub‐G\u003Cjats:sub>1\u003C\u002Fjats:sub>” peak. The HO342\u002F7AAD method may be particularly applicable to studies of programmed cell death in cells in which DNA fragmentation is difficult to detect by decreased DNA stainability. © 1994 Wiley‐Liss, Inc.\u003C\u002Fjats:p>",{"EN":1750},"Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow 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of Pedriatics, UCLA School of Medicine, Los Angeles, California 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A, 1968, Isolation of mononuclear cells and granulocytes from human blood, Scand J Clin Invest, 97, 77",{},{"id":26,"text":716,"url":26,"identifiers":1856},{"doi":716},{"id":26,"text":944,"url":26,"identifiers":1858},{"doi":944},{"id":26,"text":1860,"url":26,"identifiers":1861},"Gorczyca W, 1993, Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays, Cancer Res, 53, 1945",{},{"id":26,"text":1863,"url":26,"identifiers":1864},"Gougeon ML, 1992, Immunodeficiency in HIV Infection and AIDS, 115",{},{"id":26,"text":1866,"url":26,"identifiers":1867},"Kubbies M, 1993, Flow cytometric analysis of cell death pattern of apoptosis and necrosis, Cytometry, 14, 14",{},{"id":26,"text":1869,"url":26,"identifiers":1870},"10.1073\u002Fpnas.78.1.363",{"doi":1869},{"id":26,"text":1872,"url":26,"identifiers":1873},"Li J, 1992, Differential response of human thymus cells to CD2 antibodies: Fragmentation of DNA of CD45RO+ and proliferation of CD45RO‐ subsets, Immunology, 75, 305",{},{"id":26,"text":1875,"url":26,"identifiers":1876},"10.1177\u002F28.1.6153191",{"doi":1875},{"id":26,"text":1878,"url":26,"identifiers":1879},"10.1002\u002Fcyto.990130803",{"doi":1878},{"id":26,"text":1881,"url":26,"identifiers":1882},"McConkey DJ, 1989, Calcium‐dependent killing of immature thymocytes by stimulation via the CD3\u002FT cell receptor complex, J Immunol, 143, 1801, 10.4049\u002Fjimmunol.143.6.1801",{"doi":1883},"10.4049\u002Fjimmunol.143.6.1801",{"id":26,"text":1885,"url":26,"identifiers":1886},"10.1016\u002F0022-1759(91)90198-O",{"doi":1885},{"id":26,"text":1888,"url":26,"identifiers":1889},"10.1016\u002F0022-1759(92)90305-D",{"doi":1888},{"id":26,"text":1891,"url":26,"identifiers":1892},"Ormerod MG, 1993, Characterization of apoptosis in rat thymocytes by flow cytometry, Cytometry, 14, 14",{},{"id":26,"text":1230,"url":26,"identifiers":1894},{"doi":1230},{"id":26,"text":1053,"url":26,"identifiers":1896},{"doi":1053},{"id":26,"text":1431,"url":26,"identifiers":1898},{"doi":1431},{"id":26,"text":1014,"url":26,"identifiers":1900},{"doi":1014},{"id":26,"text":1902,"url":26,"identifiers":1903},"Tedder TF, 1985, Human lymphocyte differentiation antigens HB‐10 and HB‐11 I. Ontogeny of expression, J Immunol, 134, 2983, 10.4049\u002Fjimmunol.134.5.2983",{"doi":1904},"10.4049\u002Fjimmunol.134.5.2983",{"id":26,"text":1020,"url":26,"identifiers":1906},{"doi":1020},{"id":26,"text":1908,"url":26,"identifiers":1909},"Uittenbogaart CH, 1983, Growth of human malignant cell lines in serum free medium. In Vitro, 19, 72",{},{"id":26,"text":1434,"url":26,"identifiers":1911},{"doi":1434},{"id":1913,"createTime":1914,"updateTime":1914,"relativeEntities":1915,"slug":1916,"properties":1917,"entityType":717,"verifyStatus":25,"verifyTime":1914,"verifyNote":719,"syncStatus":28,"languages":1931,"translateLanguages":26,"viewCount":36,"primaryUrl":1932,"fullTextUrl":26,"authors":1933,"publicationType":838,"publisherRelationship":2039,"citationCount":2061,"citationInfo":2062,"publishDate":2064,"publishYear":1538,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2065,"isForceReanalyzing":1058},"b0eb7258-18fc-4e86-8553-2903804194bc","2025-01-23T10:11:05.365+00:00",[],"Flow-cytometric-detection-of-activated-mouse-integrin-%CE%B1IIb%CE%B23-with-a-novel-monoclonal-antibody",{"mag":1918,"keywords":1920,"openalex":1921,"abstract":1923,"title":1925,"pm":1927,"doi":1929},{"VOID":1919},"2022628951",{},{"VOID":1922},"W2022628951",{"EN":1924},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>Integrin αIIbβ3 mediates platelet adhesion and aggregation and plays a crucial role in thrombosis and hemostasis. αIIbβ3 is expressed in a low affinity state on resting platelets. Upon platelet activation, αIIbβ3 shifts to a high affinity conformation that efficiently binds its ligands. On human platelets, the high affinity conformation of αIIbβ3 is detected by the monoclonal antibody (mAb), PAC‐1. However, a reagent with binding specificity to high affinity mouse αIIbβ3 has not been described so far.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>A novel rat mAb directed against mouse αIIbβ3 (JON\u002FA) was generated and characterized. JON\u002FA was conjugated with fluorescein isothiocyanate (JON\u002FA\u003Cjats:sup>FITC\u003C\u002Fjats:sup>) or with R‐phycoerythrin (JON\u002FA\u003Cjats:sup>PE\u003C\u002Fjats:sup>) and used for flow cytometric analysis of mouse platelets.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Although JON\u002FA\u003Cjats:sup>FITC\u003C\u002Fjats:sup> bound to resting and activated platelets, virtually no binding of the larger JON\u002FA\u003Cjats:sup>PE\u003C\u002Fjats:sup> to resting platelets was detectable. However, strong binding of JON\u002FA\u003Cjats:sup>PE\u003C\u002Fjats:sup> occurred on platelet activation in a dose‐dependent manner. Binding of JON\u002FA\u003Cjats:sup>PE\u003C\u002Fjats:sup> required extracellular free calcium and was irreversible, thereby stabilizing the high affinity conformation of αIIbβ3.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>JON\u002FA\u003Cjats:sup>PE\u003C\u002Fjats:sup> is the first tool for direct assessment of integrin αIIbβ3 activation in mice. Furthermore, JON\u002FA\u003Cjats:sup>FITC\u003C\u002Fjats:sup> and JON\u002FA\u003Cjats:sup>PE\u003C\u002Fjats:sup> provide the first examples of fluorescent antibody derivatives with identical antigenic specificitiy that allow the discrimination between the resting and the activated state of an integrin. Cytometry 48:80–86, 2002. © 2002 Wiley‐Liss, Inc.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1926},"Flow cytometric detection of activated mouse integrin αIIbβ3 with a novel monoclonal 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JD, 1986, Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses, Am J Pathol, 124, 324",{},{"id":26,"text":2070,"url":26,"identifiers":2071},"Cramer EM, 1990, Alpha‐granule pool of glycoprotein IIb‐IIIa in normal and pathologic platelets and megakaryocytes, Blood, 75, 1220, 10.1182\u002Fblood.V75.6.1220.1220",{"doi":2072},"10.1182\u002Fblood.V75.6.1220.1220",{"id":26,"text":2074,"url":26,"identifiers":2075},"10.1055\u002Fs-0037-1615849",{"doi":2074},{"id":26,"text":2077,"url":26,"identifiers":2078},"Woods VLJ, 1986, Resting platelets contain a substantial centrally located pool of glycoprotein IIb‐IIIa complex which may be accessible to some but not other extracellular proteins, J Biol Chem, 261, 15242, 10.1016\u002FS0021-9258(18)66859-0",{"doi":2079},"10.1016\u002FS0021-9258(18)66859-0",{"id":26,"text":2081,"url":26,"identifiers":2082},"10.1016\u002F0092-8674(91)90451-4",{"doi":2081},{"id":26,"text":2084,"url":26,"identifiers":2085},"10.1016\u002FS0021-9258(17)39154-8",{"doi":2084},{"id":26,"text":2087,"url":26,"identifiers":2088},"10.1182\u002Fblood.V70.1.307.307",{"doi":2087},{"id":26,"text":2090,"url":26,"identifiers":2091},"Smyth SS, 2000, Structure and function of murine alphaIIbbeta3 (GPIIb\u002FIIIa): studies using monoclonal antibodies and beta3‐null mice, Thromb Haemost, 84, 1103, 10.1055\u002Fs-0037-1614177",{"doi":2092},"10.1055\u002Fs-0037-1614177",{"id":26,"text":2094,"url":26,"identifiers":2095},"10.1172\u002FJCI5487",{"doi":2094},{"id":26,"text":2097,"url":26,"identifiers":2098},"Nieswandt B, 1999, Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb\u002FIIIa antibody in mice, Blood, 94, 684, 10.1182\u002Fblood.V94.2.684",{"doi":2099},"10.1182\u002Fblood.V94.2.684",{"id":26,"text":2101,"url":26,"identifiers":2102},"10.1182\u002Fblood.V96.7.2520",{"doi":2101},{"id":26,"text":2104,"url":26,"identifiers":2105},"10.1182\u002Fblood.V95.3.886.003k45_886_893",{"doi":2104},{"id":26,"text":2107,"url":26,"identifiers":2108},"10.1074\u002Fjbc.270.26.15644",{"doi":2107},{"id":26,"text":2110,"url":26,"identifiers":2111},"Asselin J, 1997, A collagen‐like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1, Blood, 89, 1235, 10.1182\u002Fblood.V89.4.1235",{"doi":2112},"10.1182\u002Fblood.V89.4.1235",{"id":26,"text":2114,"url":26,"identifiers":2115},"Sims PJ, 1991, Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb‐IIIa complex, J Biol Chem, 266, 7345, 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energy transfer efficiency E was measured between fluorescein‐conjugated concanavalin A (Con A) and rhodamine‐conjugated Con A bound to homogeneous tissue culture cells, the HK22 murine lymphoma cell line. Results from a flow cytometric energy transfer method (FCET) and two different steady‐state fluorimeter methods were compared. The data were found to be in close agreement after careful correction of the steady‐state fluorimetric measurements for contributions from dissociating ligand. The biological variability of the individual cells with respect to E was calculated using an error propagation analysis and were found to be less than the variability in the absolute amount of ligand binding per cell. FCET has a number of advantages over the fluorimetric measurements using suspensions of cells: (1) relatively labile receptor‐ligand complexes can be measured; (2) the analysis can be restricted to undamaged cells by gating the data collection on the light‐scattering signals; (3) heterogeneous populations of cells with respect to donor and acceptor topology can be distinguished by the correlation of E with other cellular parameters derived from additional signals or combinations thereof; and (4) the dynamics of donor‐acceptor redistribution on subpopulations can be measured.\u003C\u002Fjats:p>",{"EN":2140},"Fluorescence energy transfer measurements on cell surfaces: A critical comparison of steady‐state fluorimetric and flow cytometric methods",{"VOID":2142},"6714028",{"VOID":2144},"10.1002\u002Fcyto.990050216",[102],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.990050216",[2148,2167,2187,2202,2221,2238],{"id":2149,"sortIndex":114,"researcher":26,"roles":2150,"affiliations":2151,"properties":2162},"65fe1f12-c872-42df-817d-96bf9a07afaa",[],[2152],{"id":2153,"sortIndex":36,"affiliation":2154,"properties":26},"ae4b0503-1da2-4255-875a-18f76d61e02f",{"id":2155,"createTime":2156,"updateTime":2156,"relativeEntities":2157,"slug":2158,"properties":2159,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"0ea02512-f69a-49f6-b305-a0ab61482ef2","2025-01-01T15:30:48.182+00:00",[],"Department-of-Biophysics-Medical-University-School-of-Debrecen-H-4012-Debrecen-Hungary",{"title":2160},{"EN":2161},"Department of Biophysics, Medical University School of Debrecen, H‐4012, Debrecen, Hungary",{"openalex":2163,"title":2165},{"VOID":2164},"A5036652138",{"EN":2166},"Sándor Damjanovich",{"id":2168,"sortIndex":162,"researcher":26,"roles":2169,"affiliations":2170,"properties":2182},"82dd8bc8-0331-4468-850d-707baf102a23",[],[2171],{"id":2172,"sortIndex":36,"affiliation":2173,"properties":26},"3e88efd7-d933-43f3-a807-d8fdca9e3eb0",{"id":2174,"createTime":2175,"updateTime":2176,"relativeEntities":2177,"slug":2178,"properties":2179,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"0a098716-ad06-4660-9adc-e66fe97df493","2025-01-01T15:30:48.209+00:00","2025-06-11T22:57:42.050+00:00",[],"Max-Planck-Institut-f%C3%BCr-Biophysikalische-Chemie-Abteilung-Molekulare-Biologie-3400-G%C3%B6ttingen-FRG",{"title":2180},{"EN":2181},"Max‐Planck‐Institut für Biophysikalische Chemie, Abteilung Molekulare Biologie, 3400 Göttingen, FRG",{"openalex":2183,"title":2185},{"VOID":2184},"A5105885810",{"EN":2186},"Thomas M. 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Quantitative evaluation of the transfer efficiency on a cell‐by‐cell basis. 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Monoparametric DNA analysis usually allows identification of apoptotic cells as a “subdiploid” peak. Progression through apoptosis leads to chromatin condensation, nuclear fragmentation and eventually to cell disruption. Thus, a major problem for the flow cytometric analysis of apoptotic populations is discrimination between debris and apoptotic cells. Here we demonstrate that the best parameter on which to make such a distinction is the DNA content, no matter what type of cell is studied. In contrast, discrimination between apoptotic, non‐apoptotic cells, and debris is possible on the basis of scattering signals only in few selected cases, depending on the morphology of the intact cells. © 1993 Wiley‐Liss, Inc.\u003C\u002Fjats:p>",{"EN":2339},"Optimal detection of apoptosis by flow cytometry depends on cell morphology",{"VOID":2341},"8287732",{"VOID":2343},"10.1002\u002Fcyto.990140807","2024-12-12T23:42:26.581+00:00",[102],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.990140807",[2348,2389,2410,2429,2450],{"id":2349,"sortIndex":111,"researcher":26,"roles":2350,"affiliations":2351,"properties":2382},"dbb61199-68e8-4d42-b1df-ba3400d986db",[],[2352,2362,2372],{"id":2353,"sortIndex":114,"affiliation":2354,"properties":26},"3b3e5fab-7dab-4e48-a8bc-5d87db538686",{"id":2355,"createTime":2356,"updateTime":2356,"relativeEntities":2357,"slug":2358,"properties":2359,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a2abd603-c838-4898-9afc-fb2d0964a42c","2024-12-12T23:42:26.803+00:00",[],"Istituto-di-Anatoa-Umana-Normale-University-of-Bologna-via-Irnerio-48-40126-Bologna-Italy",{"title":2360},{"EN":2361},"Istituto di Anatoa Umana Normale, University of Bologna, via Irnerio 48, 40126 Bologna, Italy",{"id":2363,"sortIndex":115,"affiliation":2364,"properties":26},"55dda53a-ea7f-489e-a4e3-d088ead42ba8",{"id":2365,"createTime":2366,"updateTime":2366,"relativeEntities":2367,"slug":2368,"properties":2369,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"18ba81e1-9cf6-42e3-a432-02383e8b72a4","2024-12-12T23:42:26.627+00:00",[],"Ist-Citomorfologia-N-P-C-N-R-c-o-Istituto-di-Ricerca-Codivilla-Putti-Bologna",{"title":2370},{"EN":2371},"Ist. 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10.4049\u002Fjimmunol.139.10.3199",{"doi":2518},"10.4049\u002Fjimmunol.139.10.3199",{"id":26,"text":2520,"url":26,"identifiers":2521},"10.1016\u002F0014-5793(92)80914-3",{"doi":2520},{"id":26,"text":1014,"url":26,"identifiers":2523},{"doi":1014},{"id":26,"text":1020,"url":26,"identifiers":2525},{"doi":1020},{"id":26,"text":2527,"url":26,"identifiers":2528},"10.1016\u002F0092-8674(91)90002-G",{"doi":2527},{"id":26,"text":1044,"url":26,"identifiers":2530},{},{"id":2532,"createTime":2533,"updateTime":2533,"relativeEntities":2534,"slug":2535,"properties":2536,"entityType":717,"verifyStatus":25,"verifyTime":2533,"verifyNote":719,"syncStatus":28,"languages":2550,"translateLanguages":26,"viewCount":36,"primaryUrl":2551,"fullTextUrl":26,"authors":2552,"publicationType":838,"publisherRelationship":2572,"citationCount":126,"citationInfo":2594,"publishDate":2596,"publishYear":2597,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2598,"isForceReanalyzing":1058},"2b4a81a6-be45-47ef-8358-743ca5b4b180","2024-10-06T16:30:43.097+00:00",[],"Nucleic-acid-dyes-for-detection-of-apoptosis-in-live-cells",{"mag":2537,"keywords":2539,"openalex":2540,"abstract":2542,"title":2544,"pm":2546,"doi":2548},{"VOID":2538},"2038512880",{},{"VOID":2541},"W2038512880",{"EN":2543},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Apoptotic thymocytes were found to be much dimmer than normal thymocytes when stained with several nucleic acid dyes. These dyes provide a quick and simple assay for apoptosis which works for live cells and does not require a UV laser. The collection of dyes giving this staining pattern includes reagents suitable for use in either the FL1, FL2, or FL3 channel of a standard FACScan. Cells identified by these reagents were identical to apoptotic thymocytes defined by several widely used criteria: (i) rapid uptake of Hoechst 33342 but exclusion of propidium iodide, (ii) merocyanin 540 bright, and (iii) sub‐G\u003Cjats:sub>1\u003C\u002Fjats:sub> DNA content when permeabilized in a buffer that elutes fragmented DNA. In addition, L3T4\u002FThy‐1 dim thymocytes were included in the dye dim population. The standard Hoechst 33342 and merocyanin 540 assays were not able to separate the normal and apoptotic populations in HL‐60 cells treated with camptothecin. However, the dyes SYTO‐16 and LDS‐751 both gave adequate differentiation of apoptotic from nonapoptotic cells in this model system. Some of these dyes also emit very little in other fluorescence channels of the flow cytometer and can be used in multicolor assays on cytometers equipped with only a single argon‐ion laser. © 1995 Wiley‐Liss, Inc.\u003C\u002Fjats:p>",{"EN":2545},"Nucleic acid dyes for detection of apoptosis in live cells",{"VOID":2547},"8582249",{"VOID":2549},"10.1002\u002Fcyto.990210307",[102],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fcyto.990210307",[2553],{"id":2554,"sortIndex":36,"researcher":26,"roles":2555,"affiliations":2556,"properties":2567},"409fb30a-8210-4b80-83a3-1b1d9ad81d49",[],[2557],{"id":2558,"sortIndex":36,"affiliation":2559,"properties":26},"0c487b94-3a14-424e-b454-e2bcbdb9860d",{"id":2560,"createTime":2561,"updateTime":2561,"relativeEntities":2562,"slug":2563,"properties":2564,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2446e86e-55fd-4657-b4be-0cafc1b00ee8","2024-10-06T16:30:43.111+00:00",[],"Becton-Dickinson-Immunocytometry-Systems-San-Jose-California-95131-USA-",{"title":2565},{"EN":2566},"Becton Dickinson Immunocytometry Systems, San Jose, California 95131, USA.",{"openalex":2568,"title":2570},{"VOID":2569},"A5079210545",{"EN":2571},"Tom Frey",{"url":26,"publisher":2573,"properties":2588},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2574,"slug":663,"properties":2575,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2579,"manageAffiliations":2580,"indexDatabases":2581,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":2576,"eissn":2577,"title":2578},{"VOID":666},{"VOID":668},{"EN":663},[],[],[2582],{"id":674,"indexDatabase":2583,"url":687,"indexYears":688,"academicFieldIds":26,"indexDatabaseRanking":689},{"id":676,"createTime":677,"updateTime":678,"relativeEntities":2584,"label":2585,"description":2586,"key":684,"publicationTags":2587,"standard":26},[],{"EN":681,"VI":681},{"EN":681,"VI":683},[686],{"volume":2589,"pages":2591,"issue":2593},{"VOID":2590},"21",{"VOID":2592},"265-274",{"VOID":1155},{"total":126,"publishYear":26,"statisticByYear":2595},{"2012":59,"2013":162,"2014":59,"2015":59,"2016":162,"2017":162,"2018":111,"2019":114,"2020":115,"2021":59,"2022":114,"2024":115},"1995-11-01",1995,[2599,2602,2605,2609,2612,2614,2617,2621,2623,2626,2628,2630,2632,2636,2639,2642,2645,2647,2650,2653,2656,2659,2661,2665,2669,2672,2675,2678,2680,2684,2686,2689,2692,2694,2697],{"id":26,"text":2600,"url":26,"identifiers":2601},"10.1002\u002Fcyto.990170108",{"doi":2600},{"id":26,"text":2603,"url":26,"identifiers":2604},"10.1002\u002Feji.1830240909",{"doi":2603},{"id":26,"text":2606,"url":26,"identifiers":2607},"Carbonari M, 1994, Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometric method, Blood, 83, 1268, 10.1182\u002Fblood.V83.5.1268.1268",{"doi":2608},"10.1182\u002Fblood.V83.5.1268.1268",{"id":26,"text":2610,"url":26,"identifiers":2611},"Catchpoole DR, 1993, Etoposide‐induced cytotoxicity in two human T‐cell leukemic lines: Delayed loss of membrane permeability rather than DNA fragmentation as an indicator of programmed cell death, Cancer Res, 53, 4287",{},{"id":26,"text":2496,"url":26,"identifiers":2613},{"doi":2496},{"id":26,"text":2615,"url":26,"identifiers":2616},"10.1042\u002Fbj2860331",{"doi":2615},{"id":26,"text":2618,"url":26,"identifiers":2619},"Cohen GM, 1993, Identification of a transitional preapoptotic population of thymocytes, J. Immunol, 151, 566, 10.4049\u002Fjimmunol.151.2.566",{"doi":2620},"10.4049\u002Fjimmunol.151.2.566",{"id":26,"text":896,"url":26,"identifiers":2622},{"doi":896},{"id":26,"text":2624,"url":26,"identifiers":2625},"10.1002\u002Fcyto.990160107",{"doi":2624},{"id":26,"text":716,"url":26,"identifiers":2627},{"doi":716},{"id":26,"text":905,"url":26,"identifiers":2629},{},{"id":26,"text":944,"url":26,"identifiers":2631},{"doi":944},{"id":26,"text":2633,"url":26,"identifiers":2634},"Dransfield I, 1994, Neutrophil apoptosis is associated with a reduction in CD16 (FcγRIII) Expression, J Immunol, 153, 1254, 10.4049\u002Fjimmunol.153.3.1254",{"doi":2635},"10.4049\u002Fjimmunol.153.3.1254",{"id":26,"text":2637,"url":26,"identifiers":2638},"10.1002\u002Fcyto.990190211",{"doi":2637},{"id":26,"text":2640,"url":26,"identifiers":2641},"10.1006\u002Fexcr.1994.1094",{"doi":2640},{"id":26,"text":2643,"url":26,"identifiers":2644},"10.1002\u002Fcyto.990160211",{"doi":2643},{"id":26,"text":1860,"url":26,"identifiers":2646},{},{"id":26,"text":2648,"url":26,"identifiers":2649},"10.1016\u002F0022-1759(92)90217-H",{"doi":2648},{"id":26,"text":2651,"url":26,"identifiers":2652},"10.1016\u002F0092-8674(93)80066-N",{"doi":2651},{"id":26,"text":2654,"url":26,"identifiers":2655},"10.1038\u002Fbjc.1972.33",{"doi":2654},{"id":26,"text":2657,"url":26,"identifiers":2658},"10.1182\u002Fblood.V84.5.1415.bloodjournal8451415",{"doi":2657},{"id":26,"text":1878,"url":26,"identifiers":2660},{"doi":1878},{"id":26,"text":2662,"url":26,"identifiers":2663},"Mangan DF, 1991, Lipopolysaccharide, tumor necrosis factor‐α, and IL‐1β prevent programmed cell death (apoptosis) in human peripheral blood monocytes, J Immunol, 146, 1541, 10.4049\u002Fjimmunol.146.5.1541",{"doi":2664},"10.4049\u002Fjimmunol.146.5.1541",{"id":26,"text":2666,"url":26,"identifiers":2667},"Mower DA, 1994, Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis, J Immunol, 152, 4832, 10.4049\u002Fjimmunol.152.10.4832",{"doi":2668},"10.4049\u002Fjimmunol.152.10.4832",{"id":26,"text":2670,"url":26,"identifiers":2671},"Ormerod MG, 1994, Flow cytometric studies of apoptosis, CMB, 1, 35",{},{"id":26,"text":2673,"url":26,"identifiers":2674},"10.1002\u002Fcyto.990140603",{"doi":2673},{"id":26,"text":2676,"url":26,"identifiers":2677},"10.1016\u002F0022-1759(94)90390-5",{"doi":2676},{"id":26,"text":1754,"url":26,"identifiers":2679},{"doi":1754},{"id":26,"text":2681,"url":26,"identifiers":2682},"Solary E, 1993, Differential induction of apoptosis in undifferentiated and differentiated HL‐60 cells by DNA toposomerase I and II inhibitors, Blood, 81, 1359, 10.1182\u002Fblood.V81.5.1359.1359",{"doi":2683},"10.1182\u002Fblood.V81.5.1359.1359",{"id":26,"text":1014,"url":26,"identifiers":2685},{"doi":1014},{"id":26,"text":2687,"url":26,"identifiers":2688},"10.1016\u002F0022-1759(94)90373-5",{"doi":2687},{"id":26,"text":2690,"url":26,"identifiers":2691},"10.1002\u002Fcyto.990090512",{"doi":2690},{"id":26,"text":1077,"url":26,"identifiers":2693},{"doi":1077},{"id":26,"text":2695,"url":26,"identifiers":2696},"10.1038\u002Fbjc.1993.40",{"doi":2695},{"id":26,"text":1047,"url":26,"identifiers":2698},{"doi":1047}]