[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_1b68ad21-c580-4b81-b4c6-813b8c89d124":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:1b68ad21-c580-4b81-b4c6-813b8c89d124,\"}":24},{"code":4,"data":5,"meta":19},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":21,"manageAffiliations":22,"indexDatabases":23,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},"1b68ad21-c580-4b81-b4c6-813b8c89d124","2024-09-19T17:04:27.544+00:00","2025-01-30T19:42:25.741+00:00",[],"Wiley",{"issn":12,"title":14,"eissn":15},{"VOID":13},"0192-2521",{"EN":10},{"VOID":16},"1930-238X","PUBLISHER","PENDING",null,0,[],[],[],{"meta":25,"data":27},{"total":26},"17",[28,263,537,803,1016,1263,1457,1673,1859,2253],{"id":29,"createTime":30,"updateTime":31,"relativeEntities":32,"slug":33,"properties":34,"entityType":47,"verifyStatus":48,"verifyTime":30,"verifyNote":49,"languages":50,"translateLanguages":19,"viewCount":20,"primaryUrl":52,"fullTextUrl":19,"authors":53,"publicationType":143,"publisherRelationship":144,"citationCount":20,"citationInfo":161,"publishDate":164,"publishYear":162,"citationAnalyzeStatus":18,"lastCitationAnalyze":165,"indexDatabases":166,"openAccess":19,"references":167,"isForceReanalyzing":262},"e92b7374-639f-474a-8073-dbd4ac4724bc","2024-10-05T22:30:41.580+00:00","2026-04-23T04:24:01.973+00:00",[],"Salmonella-mutagenicity-test-results-for-250-chemicals",{"openalex":35,"mag":37,"title":39,"gsPaper":41,"pm":43,"doi":45},{"VOID":36},"W2028773528",{"VOID":38},"2028773528",{"EN":40},"Salmonella mutagenicity test results for 250 chemicals",{"VOID":42},"[\"10810810659519408111\"]",{"VOID":44},"6365529",{"VOID":46},"10.1002\u002Fem.2860050703","PUBLICATION","VERIFIED","Auto Verify",[51],"EN","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860050703",[54,71,87,107,125],{"id":55,"sortIndex":20,"researcher":19,"roles":56,"affiliations":57,"properties":66,"displayName":68,"givenName":19,"familyName":19},"29f4cf36-44be-418e-b9d4-4b4ab6fc9bd8",[],[58],{"id":59,"sortIndex":20,"affiliation":60,"properties":19},"d02c32ad-39fd-4e9b-b20b-89c487588048",{"id":59,"createTime":19,"updateTime":19,"relativeEntities":61,"slug":19,"properties":62,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":65,"statistic":19},[],{"title":63},{"EN":64},"Genetic Toxicology Department, Microbiological Associates, Bethesda, Maryland",[],{"title":67,"openalex":69},{"EN":68},"Steve Haworth",{"VOID":70},"A5051702889",{"id":72,"sortIndex":73,"researcher":19,"roles":74,"affiliations":75,"properties":82,"displayName":84,"givenName":19,"familyName":19},"901bae2a-4f34-48d7-8f29-7eaa90251ac7",1,[],[76],{"id":59,"sortIndex":20,"affiliation":77,"properties":19},{"id":59,"createTime":19,"updateTime":19,"relativeEntities":78,"slug":19,"properties":79,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":81,"statistic":19},[],{"title":80},{"EN":64},[],{"title":83,"openalex":85},{"EN":84},"Timothy E. Lawlor",{"VOID":86},"A5105413735",{"id":88,"sortIndex":89,"researcher":19,"roles":90,"affiliations":91,"properties":100,"displayName":104,"givenName":19,"familyName":19},"2b790c0d-39ea-4423-a343-32cfd355d8f5",2,[],[92],{"id":93,"sortIndex":20,"affiliation":94,"properties":19},"b7c3c323-56a8-4417-afa8-f3a241ae064c",{"id":93,"createTime":19,"updateTime":19,"relativeEntities":95,"slug":19,"properties":96,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":99,"statistic":19},[],{"title":97},{"EN":98},"Microbial Genetics Department, SRI International, Menlo Park, California",[],{"orcid":101,"title":103,"openalex":105},{"VOID":102},"https:\u002F\u002Forcid.org\u002F0000-0002-6812-2384",{"EN":104},"Kristien Mortelmans",{"VOID":106},"A5063047668",{"id":108,"sortIndex":109,"researcher":19,"roles":110,"affiliations":111,"properties":120,"displayName":122,"givenName":19,"familyName":19},"57b348fd-90ed-483e-8585-4c1137a85e0e",3,[],[112],{"id":113,"sortIndex":20,"affiliation":114,"properties":19},"b78ad955-fa42-4ade-9b88-95e67be0cdfc",{"id":113,"createTime":19,"updateTime":19,"relativeEntities":115,"slug":19,"properties":116,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":119,"statistic":19},[],{"title":117},{"VI":118},"Department of Pediatrics, Case Western Reserve University, Cleveland",[],{"title":121,"openalex":123},{"EN":122},"William T. Speck",{"VOID":124},"A5044255932",{"id":126,"sortIndex":127,"researcher":19,"roles":128,"affiliations":129,"properties":138,"displayName":140,"givenName":19,"familyName":19},"d888a929-20f2-4f18-9f7b-9d92db4b35bf",4,[],[130],{"id":131,"sortIndex":20,"affiliation":132,"properties":19},"ad6fcbef-6c08-4faa-a438-4de21310f18a",{"id":131,"createTime":19,"updateTime":19,"relativeEntities":133,"slug":19,"properties":134,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":137,"statistic":19},[],{"title":135},{"VI":136},"Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina",[],{"title":139,"openalex":141},{"EN":140},"Errol Zeiger",{"VOID":142},"A5028287356","ARTICLE",{"url":19,"publisher":145,"properties":154},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":146,"slug":10,"properties":147,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":151,"manageAffiliations":152,"indexDatabases":153,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":148,"title":149,"eissn":150},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":155,"pages":157,"volume":159},{"VOID":156},"S1",{"VOID":158},"3-49",{"VOID":160},"5",{"total":20,"publishYear":162,"statisticByYear":163},1983,{},"1983-01-01","2026-04-23T04:24:01.972+00:00",[],[168,172,176,179,183,187,191,194,197,200,203,206,209,212,216,219,223,227,230,234,238,241,244,247,251,255,259],{"id":19,"text":169,"url":19,"identifiers":170},"Ames, 1975, Mutat Res, 31, 347, 10.1016\u002F0165-1161(75)90046-1",{"doi":171},"10.1016\u002F0165-1161(75)90046-1",{"id":19,"text":173,"url":19,"identifiers":174},"Bartsch, 1980, Mutat Res, 76, 1, 10.1016\u002F0165-1110(80)90002-0",{"doi":175},"10.1016\u002F0165-1110(80)90002-0",{"id":19,"text":177,"url":19,"identifiers":178},"Bartsch, 1975, Cancer Res, 35, 644",{},{"id":19,"text":180,"url":19,"identifiers":181},"Hartman, 1978, Mutat Res, 58, 125, 10.1016\u002F0165-1218(78)90001-0",{"doi":182},"10.1016\u002F0165-1218(78)90001-0",{"id":19,"text":184,"url":19,"identifiers":185},"Margolin, 1981, Proc Natl Acad Sci USA, 78, 3779, 10.1073\u002Fpnas.78.6.3779",{"doi":186},"10.1073\u002Fpnas.78.6.3779",{"id":19,"text":188,"url":19,"identifiers":189},"McCann, 1975, Proc Natl Acad Sci USA, 72, 5135, 10.1073\u002Fpnas.72.12.5135",{"doi":190},"10.1073\u002Fpnas.72.12.5135",{"id":19,"text":192,"url":19,"identifiers":193},"National Toxicology Program Technical Bulletin, Issue Number 2 (1980a).",{},{"id":19,"text":195,"url":19,"identifiers":196},"National Toxicology Program Technical Bulletin. Issue Number 3 (1980b).",{},{"id":19,"text":198,"url":19,"identifiers":199},"National Toxicology Program Technical Bulletin, Issue Number 4 (1981a).",{},{"id":19,"text":201,"url":19,"identifiers":202},"National Toxicology Program Technical Bulletin, Issue Number 5 (1981b).",{},{"id":19,"text":204,"url":19,"identifiers":205},"National Toxicology Program Technical Bulletin, Issue Number 6 (1982a).",{},{"id":19,"text":207,"url":19,"identifiers":208},"National Toxicology Program Technical Bulletin, Issue Number 7 (1982b).",{},{"id":19,"text":210,"url":19,"identifiers":211},"National Toxicology Program Technical Bulletin. Issue Number 8 (1983)",{},{"id":19,"text":213,"url":19,"identifiers":214},"Prival, 1979, Environ Mutagenesis, 1, 95, 10.1002\u002Fem.2860010202",{"doi":215},"10.1002\u002Fem.2860010202",{"id":19,"text":217,"url":19,"identifiers":218},"Prival, 1981, Cancer Res, 41, 4361",{},{"id":19,"text":220,"url":19,"identifiers":221},"Prival, 1982, Mutat Res, 97, 103, 10.1016\u002F0165-1161(82)90008-5",{"doi":222},"10.1016\u002F0165-1161(82)90008-5",{"id":19,"text":224,"url":19,"identifiers":225},"Purchase, 1978, Br J Cancer, 37, 873, 10.1038\u002Fbjc.1978.132",{"doi":226},"10.1038\u002Fbjc.1978.132",{"id":19,"text":228,"url":19,"identifiers":229},"Rinkus, 1979, Cancer Res, 39, 3289",{},{"id":19,"text":231,"url":19,"identifiers":232},"Robertson, 1982, Carcinogenesis, 3, 21, 10.1093\u002Fcarcin\u002F3.1.21",{"doi":233},"10.1093\u002Fcarcin\u002F3.1.21",{"id":19,"text":235,"url":19,"identifiers":236},", (1980): Microbial assays: Evaluation and application to the elucidation of the etiology of colon cancer. In (eds): “Short-Term Test Systems for Determining Carcinogens.” Berlin: Springer, pp 19–57.",{"doi":237},"10.1007\u002F978-3-642-67202-6_3",{"id":19,"text":239,"url":19,"identifiers":240},", (1977): Mutagenic activity of chemicals identified in drinking water. In , (eds): “Progress in Genetic Toxicology.” Amsterdam: Elsevier\u002FNorth Holland, pp 249–258.",{},{"id":19,"text":242,"url":19,"identifiers":243},", , . . , , , . , , (1977): Mutagen-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled foods. In , (eds): “Origins of Human Cancer.” Book C. Cold Spring Harbor: Cold Spring Harbor Laboratory, pp 1561–1577.",{},{"id":19,"text":245,"url":19,"identifiers":246},", , , . , , (1976): Overlapping of carcinogens and mutagens. In et al (cds): “Fundamentals in Cancer Prevention.” Baltimore: University Park Press, pp 191–215.",{},{"id":19,"text":248,"url":19,"identifiers":249},"Vogel, 1956, J Biol Chem, 218, 97, 10.1016\u002FS0021-9258(18)65874-0",{"doi":250},"10.1016\u002FS0021-9258(18)65874-0",{"id":19,"text":252,"url":19,"identifiers":253},"Yahagi, 1975, Cancer Lett, 1, 91, 10.1016\u002FS0304-3835(75)95563-9",{"doi":254},"10.1016\u002FS0304-3835(75)95563-9",{"id":19,"text":256,"url":19,"identifiers":257},"Yamanaka, 1979, Mutat Res, 68, 211, 10.1016\u002F0165-1218(79)90152-6",{"doi":258},"10.1016\u002F0165-1218(79)90152-6",{"id":19,"text":260,"url":19,"identifiers":261},"(1980): An environmental mutagenesis test development programme. In , (eds): “Molecular & Cellular Aspects of Carcinogen Screening Tests” (IARC Publication No. 27). Lyon: IARC, pp 303–313.",{},false,{"id":264,"createTime":265,"updateTime":265,"relativeEntities":266,"slug":267,"properties":268,"entityType":47,"verifyStatus":48,"verifyTime":265,"verifyNote":49,"languages":281,"translateLanguages":19,"viewCount":20,"primaryUrl":282,"fullTextUrl":19,"authors":283,"publicationType":143,"publisherRelationship":405,"citationCount":422,"citationInfo":423,"publishDate":426,"publishYear":424,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":427,"openAccess":19,"references":428,"isForceReanalyzing":262},"a64d9fdf-94f2-49d3-beff-1fc28d36dab3","2025-01-30T19:42:25.736+00:00",[],"Sister-chromatid-exchange-and-chromosome-aberration-analyses-in-mice-after-in-vivo-exposure-to-acrylonitrile-styrene-or-butadiene-monoxide",{"openalex":269,"mag":271,"abstract":273,"title":275,"pm":277,"doi":279},{"VOID":270},"W2013465473",{"VOID":272},"2013465473",{"EN":274},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The use of polymers in plastic and rubber products has generated concern that monomers potentially active in biological systems may be eluted from these substances. We have evaluated two such monomers, acrylonitrile and styrene, for the induction of chromosome damage in mice. Butadiene monoxide, a presumed metabolite of a third important monomer, 1,3‐butadiene, was also tested. These chemicals were administered as a single intraperitoneal injection; sister chromatid exchanges and chromosome aberrations were analyzed in bone marrow cells. Acrylonitrile and styrene were largely negative for these endpoints when tested at doses ranging to 60 mg\u002Fkg and 1,000 mg\u002Fkg, respectively. Butadiene monoxide, which previously has not been tested in a mammalian system, was determined to be a very effective inducer of sister chromatid exchanges and chromosome aberrations. Both endpoints showed a clear dose response and a greater than ten‐fold increase over control levels at high doses. These studies represent an initial step in our efforts to evaluate genetic risk associated with exposure to common polymeric chemicals.\u003C\u002Fjats:p>",{"EN":276},"Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide",{"VOID":278},"3709426",{"VOID":280},"10.1002\u002Fem.2860080312",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860080312",[284,301,320,337,356,371,387],{"id":285,"sortIndex":20,"researcher":19,"roles":286,"affiliations":287,"properties":296,"displayName":298,"givenName":19,"familyName":19},"0b97a592-a91c-4e68-8992-c74acce0d50b",[],[288],{"id":289,"sortIndex":20,"affiliation":290,"properties":19},"627adb37-58c3-41ff-985e-26778ae60932",{"id":289,"createTime":19,"updateTime":19,"relativeEntities":291,"slug":19,"properties":292,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":295,"statistic":19},[],{"title":293},{"EN":294},"Integrated Laboratory Systems, P.O. Box 13501, Research Triangle Park, NC 27709",[],{"title":297,"openalex":299},{"EN":298},"Yousuf Sharief",{"VOID":300},"A5015982903",{"id":302,"sortIndex":73,"researcher":19,"roles":303,"affiliations":304,"properties":313,"displayName":317,"givenName":19,"familyName":19},"ec5c71b2-d932-47b1-b8d1-df158853e9de",[],[305],{"id":306,"sortIndex":20,"affiliation":307,"properties":19},"491c7e88-3d6b-4616-97d3-71e5827e1b7c",{"id":306,"createTime":19,"updateTime":19,"relativeEntities":308,"slug":19,"properties":309,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":312,"statistic":19},[],{"title":310},{"VI":311},"Food and Drug Administration, Rockville, Maryland",[],{"orcid":314,"title":316,"openalex":318},{"VOID":315},"https:\u002F\u002Forcid.org\u002F0000-0002-8725-3195",{"EN":317},"Arthur Brown",{"VOID":319},"A5086423794",{"id":321,"sortIndex":89,"researcher":19,"roles":322,"affiliations":323,"properties":332,"displayName":334,"givenName":19,"familyName":19},"5efac374-c726-42a1-ab5c-455beae19750",[],[324],{"id":325,"sortIndex":20,"affiliation":326,"properties":19},"1e94acaf-8d3c-49e7-951a-a4d3edf0d5d5",{"id":325,"createTime":19,"updateTime":19,"relativeEntities":327,"slug":19,"properties":328,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":331,"statistic":19},[],{"title":329},{"EN":330},"U. S. Environmental Protection Agency, Research Triangle Park, North Carolina",[],{"title":333,"openalex":335},{"EN":334},"Lorraine C. Backer",{"VOID":336},"A5048494265",{"id":338,"sortIndex":109,"researcher":19,"roles":339,"affiliations":340,"properties":349,"displayName":353,"givenName":19,"familyName":19},"fbb6f862-124b-47dd-9591-29bb6d907c4f",[],[341],{"id":342,"sortIndex":20,"affiliation":343,"properties":19},"f3c0ee86-3ffe-4db5-abe7-e4360b97dc84",{"id":342,"createTime":19,"updateTime":19,"relativeEntities":344,"slug":19,"properties":345,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":348,"statistic":19},[],{"title":346},{"EN":347},"Environmental Health Research and Testing, Inc., North Carolina",[],{"orcid":350,"title":352,"openalex":354},{"VOID":351},"https:\u002F\u002Forcid.org\u002F0000-0003-3183-5417",{"EN":353},"James A. Campbell",{"VOID":355},"A5088345503",{"id":357,"sortIndex":127,"researcher":19,"roles":358,"affiliations":359,"properties":366,"displayName":368,"givenName":19,"familyName":19},"85265caf-585f-4911-8876-fa99bb42e533",[],[360],{"id":342,"sortIndex":20,"affiliation":361,"properties":19},{"id":342,"createTime":19,"updateTime":19,"relativeEntities":362,"slug":19,"properties":363,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":365,"statistic":19},[],{"title":364},{"EN":347},[],{"title":367,"openalex":369},{"EN":368},"Barbara Westbrook‐Collins",{"VOID":370},"A5033339839",{"id":372,"sortIndex":373,"researcher":19,"roles":374,"affiliations":375,"properties":382,"displayName":384,"givenName":19,"familyName":19},"c59e7946-d1df-48c1-85ba-2f86236158a3",5,[],[376],{"id":325,"sortIndex":20,"affiliation":377,"properties":19},{"id":325,"createTime":19,"updateTime":19,"relativeEntities":378,"slug":19,"properties":379,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":381,"statistic":19},[],{"title":380},{"EN":330},[],{"title":383,"openalex":385},{"EN":384},"Andrew G. Stead",{"VOID":386},"A5112221011",{"id":388,"sortIndex":389,"researcher":19,"roles":390,"affiliations":391,"properties":398,"displayName":402,"givenName":19,"familyName":19},"247861f1-62ab-404d-949e-2594ded35928",6,[],[392],{"id":325,"sortIndex":20,"affiliation":393,"properties":19},{"id":325,"createTime":19,"updateTime":19,"relativeEntities":394,"slug":19,"properties":395,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":397,"statistic":19},[],{"title":396},{"EN":330},[],{"orcid":399,"title":401,"openalex":403},{"VOID":400},"https:\u002F\u002Forcid.org\u002F0000-0002-4515-9053",{"EN":402},"James W. Allen",{"VOID":404},"A5086069191",{"url":19,"publisher":406,"properties":415},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":407,"slug":10,"properties":408,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":412,"manageAffiliations":413,"indexDatabases":414,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":409,"title":410,"eissn":411},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":416,"pages":418,"volume":420},{"VOID":417},"3",{"VOID":419},"439-448",{"VOID":421},"8",64,{"total":422,"publishYear":424,"statisticByYear":425},1986,{"2012":89,"2019":73,"2023":89},"1986-01-01",[],[429,432,435,438,441,444,447,450,453,456,459,462,465,468,471,474,477,480,483,486,489,492,495,498,501,504,507,510,513,516,519,522,525,528,531,534],{"id":19,"text":430,"url":19,"identifiers":431},"Abreu ME, 1980, Metabolism of acrylonitrile to cyanide. In vitro studies, Drug Metab Dispos, 8, 376",{},{"id":19,"text":433,"url":19,"identifiers":434},"10.1007\u002FBF01538862",{"doi":433},{"id":19,"text":436,"url":19,"identifiers":437},"10.1016\u002F0027-5107(80)90203-1",{"doi":436},{"id":19,"text":439,"url":19,"identifiers":440},"10.1016\u002F0165-7992(83)90186-0",{"doi":439},{"id":19,"text":442,"url":19,"identifiers":443},"10.1016\u002F0041-008X(80)90217-3",{"doi":442},{"id":19,"text":445,"url":19,"identifiers":446},"10.1016\u002F0027-5107(83)90124-0",{"doi":445},{"id":19,"text":448,"url":19,"identifiers":449},"10.1016\u002F0165-1161(79)90125-0",{"doi":448},{"id":19,"text":451,"url":19,"identifiers":452},"Guengerich FP, 1981, In vitro metabolism of acrylonitrile to 2‐cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acids, Cancer Res, 41, 4925",{},{"id":19,"text":454,"url":19,"identifiers":455},"10.5271\u002Fsjweh.2414",{"doi":454},{"id":19,"text":457,"url":19,"identifiers":458},"10.5271\u002Fsjweh.2649",{"doi":457},{"id":19,"text":460,"url":19,"identifiers":461},"10.1016\u002F0165-1110(81)90003-8",{"doi":460},{"id":19,"text":463,"url":19,"identifiers":464},"10.1016\u002F0378-4274(81)90056-4",{"doi":463},{"id":19,"text":466,"url":19,"identifiers":467},"10.1016\u002F0006-2952(69)90237-8",{"doi":466},{"id":19,"text":469,"url":19,"identifiers":470},"10.1016\u002F0165-1218(78)90020-4",{"doi":469},{"id":19,"text":472,"url":19,"identifiers":473},"10.5271\u002Fsjweh.2760",{"doi":472},{"id":19,"text":475,"url":19,"identifiers":476},"Maltoni C, 1977, Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion, Med Lab, 68, 401",{},{"id":19,"text":478,"url":19,"identifiers":479},"10.3109\u002F00498258209046787",{"doi":478},{"id":19,"text":481,"url":19,"identifiers":482},"10.1016\u002F0165-7992(83)90042-8",{"doi":481},{"id":19,"text":484,"url":19,"identifiers":485},"McFee AF, 1984, Influence of time on the in vivo induction of sister chromatid exchanges and chromosome aberrations, Environ Mutagen, 6, 156",{},{"id":19,"text":487,"url":19,"identifiers":488},"10.5271\u002Fsjweh.2739",{"doi":487},{"id":19,"text":490,"url":19,"identifiers":491},"10.1016\u002F0027-5107(77)90209-3",{"doi":490},{"id":19,"text":493,"url":19,"identifiers":494},"10.1016\u002F0378-4274(80)90066-1",{"doi":493},{"id":19,"text":496,"url":19,"identifiers":497},"Norppa H, 1983, Metabolic activation of styrene by erythrocytes detected as increased sister chromatid exchanges in cultured human lymphocytes, Cancer Res, 43, 3579",{},{"id":19,"text":499,"url":19,"identifiers":500},"Nutt AR, 1984, Toxic Hazards of Rubber Chemicals, 1",{},{"id":19,"text":502,"url":19,"identifiers":503},"10.5271\u002Fsjweh.2464",{"doi":502},{"id":19,"text":505,"url":19,"identifiers":506},"10.1038\u002F258121a0",{"doi":505},{"id":19,"text":508,"url":19,"identifiers":509},"10.5271\u002Fsjweh.2754",{"doi":508},{"id":19,"text":511,"url":19,"identifiers":512},"10.1016\u002F0009-2797(78)90050-9",{"doi":511},{"id":19,"text":514,"url":19,"identifiers":515},"10.1016\u002F0165-1218(80)90072-5",{"doi":514},{"id":19,"text":517,"url":19,"identifiers":518},"10.1002\u002Fem.2860070615",{"doi":517},{"id":19,"text":520,"url":19,"identifiers":521},"10.1016\u002F0009-2797(83)90081-9",{"doi":520},{"id":19,"text":523,"url":19,"identifiers":524},"10.1016\u002F0047-6374(81)90051-8",{"doi":523},{"id":19,"text":526,"url":19,"identifiers":527},"Sokal RR, 1969, Biometry: The Principles and Practice of Statistics in Biological Research",{},{"id":19,"text":529,"url":19,"identifiers":530},"10.1007\u002FBF00302526",{"doi":529},{"id":19,"text":532,"url":19,"identifiers":533},"U.S. Environmental Protection Agency(1983):The reproductive effects assessment group's report on the mutagenicity of acrylonitrile. Health Assessment Document for Acrylonitrile EPA‐600\u002F8–82–007F pp13–71.",{},{"id":19,"text":535,"url":19,"identifiers":536},"10.1016\u002F0304-3835(82)90034-9",{"doi":535},{"id":538,"createTime":539,"updateTime":539,"relativeEntities":540,"slug":541,"properties":542,"entityType":47,"verifyStatus":48,"verifyTime":539,"verifyNote":49,"languages":555,"translateLanguages":19,"viewCount":20,"primaryUrl":556,"fullTextUrl":19,"authors":557,"publicationType":143,"publisherRelationship":628,"citationCount":643,"citationInfo":644,"publishDate":164,"publishYear":162,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":646,"openAccess":19,"references":647,"isForceReanalyzing":262},"d04585ca-9af5-480b-b408-67e91960aa1d","2025-01-30T19:41:52.230+00:00",[],"Chromosome-aberrations-and-sister-chromatid-exchanges-in-styrene-exposed-workers-with-reference-to-their-smoking-habits",{"openalex":543,"mag":545,"abstract":547,"title":549,"pm":551,"doi":553},{"VOID":544},"W2026746027",{"VOID":546},"2026746027",{"EN":548},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The incidences of chromosome aberrations and the frequencies of sister chromatid exchanges (SCE) were investigated in cultured lymphocytes of 18 styrene‐exposed workers in comparison with six controls. There was a marginal increase in the incidence of structural chromosomal aberrations in first‐division metaphases in the styrene‐exposed workers, as compared with the nonexposed controls. However, there was no difference in SCE frequencies. When each group was divided into smokers and nonsmokers, styrene‐exposed smokers tended to have higher SCE frequencies than styrene‐exposed nonsmokers. Furthermore, cell proliferation was inhibited in styrene‐exposed workers (both smokers and nonsmokers) and control smokers.\u003C\u002Fjats:p>",{"EN":550},"Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking habits",{"VOID":552},"6851971",{"VOID":554},"10.1002\u002Fem.2860050308",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860050308",[558,577,594,611],{"id":559,"sortIndex":20,"researcher":19,"roles":560,"affiliations":561,"properties":570,"displayName":574,"givenName":19,"familyName":19},"efe964b9-2d6a-4c86-ad0e-3efaf5a26f12",[],[562],{"id":563,"sortIndex":20,"affiliation":564,"properties":19},"6c9b5357-bc5d-4989-bee7-c914436c4eb3",{"id":563,"createTime":19,"updateTime":19,"relativeEntities":565,"slug":19,"properties":566,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":569,"statistic":19},[],{"title":567},{"VI":568},"Department of Hygiene & Preventive Medicine, Yamagata University School of Medicine, Yamagata, Japan",[],{"orcid":571,"title":573,"openalex":575},{"VOID":572},"https:\u002F\u002Forcid.org\u002F0000-0002-8250-8654",{"EN":574},"Toshiaki Watanabe",{"VOID":576},"A5027839397",{"id":578,"sortIndex":73,"researcher":19,"roles":579,"affiliations":580,"properties":587,"displayName":591,"givenName":19,"familyName":19},"82d1450a-81be-488a-bbd3-6f57c2eea589",[],[581],{"id":563,"sortIndex":20,"affiliation":582,"properties":19},{"id":563,"createTime":19,"updateTime":19,"relativeEntities":583,"slug":19,"properties":584,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":586,"statistic":19},[],{"title":585},{"VI":568},[],{"orcid":588,"title":590,"openalex":592},{"VOID":589},"https:\u002F\u002Forcid.org\u002F0000-0001-9695-4172",{"EN":591},"Akira Endo",{"VOID":593},"A5049981252",{"id":595,"sortIndex":89,"researcher":19,"roles":596,"affiliations":597,"properties":606,"displayName":608,"givenName":19,"familyName":19},"988515c6-8b42-4d7f-ade7-30d674d2d95f",[],[598],{"id":599,"sortIndex":20,"affiliation":600,"properties":19},"a574025f-1ab3-4cfe-80a9-d4ecd7ca4f1f",{"id":599,"createTime":19,"updateTime":19,"relativeEntities":601,"slug":19,"properties":602,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":605,"statistic":19},[],{"title":603},{"VI":604},"Department of Environmental Health, Tohoku University School of Medicine, Sendai, Japan",[],{"title":607,"openalex":609},{"EN":608},"Miho Kumai",{"VOID":610},"A5110143381",{"id":612,"sortIndex":109,"researcher":19,"roles":613,"affiliations":614,"properties":621,"displayName":625,"givenName":19,"familyName":19},"e05ca465-bd02-4fc7-9e20-13d846e477fe",[],[615],{"id":599,"sortIndex":20,"affiliation":616,"properties":19},{"id":599,"createTime":19,"updateTime":19,"relativeEntities":617,"slug":19,"properties":618,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":620,"statistic":19},[],{"title":619},{"VI":604},[],{"orcid":622,"title":624,"openalex":626},{"VOID":623},"https:\u002F\u002Forcid.org\u002F0000-0002-6833-9495",{"EN":625},"Masayuki Ikeda",{"VOID":627},"A5010210218",{"url":19,"publisher":629,"properties":638},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":630,"slug":10,"properties":631,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":635,"manageAffiliations":636,"indexDatabases":637,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":632,"title":633,"eissn":634},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":639,"pages":640,"volume":642},{"VOID":417},{"VOID":641},"299-309",{"VOID":160},43,{"total":643,"publishYear":162,"statisticByYear":645},{"2020":73,"2021":73,"2023":73},[],[648,650,653,656,659,662,665,668,671,674,677,679,682,685,688,691,693,696,699,702,705,708,711,714,717,720,723,726,728,731,734,737,739,742,744,747,749,752,755,758,761,764,767,770,773,776,779,782,785,788,791,794,797,800],{"id":19,"text":436,"url":19,"identifiers":649},{"doi":436},{"id":19,"text":651,"url":19,"identifiers":652},"10.1016\u002F0165-1218(80)90100-7",{"doi":651},{"id":19,"text":654,"url":19,"identifiers":655},"10.1016\u002F0027-5107(82)90232-9",{"doi":654},{"id":19,"text":657,"url":19,"identifiers":658},"10.5271\u002Fsjweh.2729",{"doi":657},{"id":19,"text":660,"url":19,"identifiers":661},"10.1016\u002F0165-1218(82)90106-9",{"doi":660},{"id":19,"text":663,"url":19,"identifiers":664},"10.1016\u002F0165-1218(82)90148-3",{"doi":663},{"id":19,"text":666,"url":19,"identifiers":667},"Brøgger A, 1982, Sister Chromatid Exchange, 665",{},{"id":19,"text":669,"url":19,"identifiers":670},"CamurriL CodeluppiS PedroniC(1982):Chromosomal aberrations and sister chromatid exchanges in styrene exposed workers. In: 12th Annual Meeting of European Environmental Mutagen Society Espoo Finland June20–24 (Abstr) p159.",{},{"id":19,"text":672,"url":19,"identifiers":673},"Carrano AV, 1981, Sister chromatid exchange frequencies in humans: The effect of smoking, Environ Mutagen (Abstr), 3, 339",{},{"id":19,"text":675,"url":19,"identifiers":676},"10.1016\u002FB978-0-12-336180-6.50014-4",{"doi":675},{"id":19,"text":442,"url":19,"identifiers":678},{"doi":442},{"id":19,"text":680,"url":19,"identifiers":681},"10.1016\u002F0014-4827(77)90116-1",{"doi":680},{"id":19,"text":683,"url":19,"identifiers":684},"10.1007\u002FBF00287068",{"doi":683},{"id":19,"text":686,"url":19,"identifiers":687},"Evans HJ, 1981, Cigarette smoke induced DNA damage in man, Prog Mutat Res, 2, 111",{},{"id":19,"text":689,"url":19,"identifiers":690},"10.5271\u002Fsjweh.2740",{"doi":689},{"id":19,"text":457,"url":19,"identifiers":692},{"doi":457},{"id":19,"text":694,"url":19,"identifiers":695},"10.1007\u002FBF00295409",{"doi":694},{"id":19,"text":697,"url":19,"identifiers":698},"10.1038\u002F283388a0",{"doi":697},{"id":19,"text":700,"url":19,"identifiers":701},"10.1111\u002Fj.1601-5223.1980.tb01704.x",{"doi":700},{"id":19,"text":703,"url":19,"identifiers":704},"10.1111\u002Fj.1399-6576.1980.tb01498.x",{"doi":703},{"id":19,"text":706,"url":19,"identifiers":707},"10.2307\u002F3575530",{"doi":706},{"id":19,"text":709,"url":19,"identifiers":710},"10.1016\u002F0165-1161(81)90226-0",{"doi":709},{"id":19,"text":712,"url":19,"identifiers":713},"10.1111\u002Fj.1601-5223.1982.tb00037.x",{"doi":712},{"id":19,"text":715,"url":19,"identifiers":716},"10.1016\u002F0165-1161(81)90120-5",{"doi":715},{"id":19,"text":718,"url":19,"identifiers":719},"10.1007\u002FBF00377941",{"doi":718},{"id":19,"text":721,"url":19,"identifiers":722},"10.1080\u002F15287398009529942",{"doi":721},{"id":19,"text":724,"url":19,"identifiers":725},"10.1111\u002Fj.1601-5223.1978.tb01617.x",{"doi":724},{"id":19,"text":469,"url":19,"identifiers":727},{"doi":469},{"id":19,"text":729,"url":19,"identifiers":730},"10.1080\u002F15287398009529896",{"doi":729},{"id":19,"text":732,"url":19,"identifiers":733},"10.1111\u002Fj.1601-5223.1981.tb01764.x",{"doi":732},{"id":19,"text":735,"url":19,"identifiers":736},"10.1016\u002F0165-7992(82)90011-2",{"doi":735},{"id":19,"text":490,"url":19,"identifiers":738},{"doi":490},{"id":19,"text":740,"url":19,"identifiers":741},"10.1016\u002F0378-4274(78)90013-9",{"doi":740},{"id":19,"text":487,"url":19,"identifiers":743},{"doi":487},{"id":19,"text":745,"url":19,"identifiers":746},"10.1007\u002FBF00278683",{"doi":745},{"id":19,"text":493,"url":19,"identifiers":748},{"doi":493},{"id":19,"text":750,"url":19,"identifiers":751},"10.1016\u002F0165-7992(81)90040-3",{"doi":750},{"id":19,"text":753,"url":19,"identifiers":754},"10.1007\u002FBF00284759",{"doi":753},{"id":19,"text":756,"url":19,"identifiers":757},"10.1016\u002F0027-5107(82)90233-0",{"doi":756},{"id":19,"text":759,"url":19,"identifiers":760},"10.1007\u002FBF00385707",{"doi":759},{"id":19,"text":762,"url":19,"identifiers":763},"10.1038\u002F251156a0",{"doi":762},{"id":19,"text":765,"url":19,"identifiers":766},"10.1016\u002F0165-1161(82)90011-5",{"doi":765},{"id":19,"text":768,"url":19,"identifiers":769},"Sorsa M, 1979, Chromosomal aberrations and sister chromatid exchange in children of women in reinforced plastic industry. Sym Toxicol, 16",{},{"id":19,"text":771,"url":19,"identifiers":772},"Šarrám RJ, 1981, Industrial and Environmental Xenobiotics. Metabolism and Pharmacokinetics of Organic Chemicals and Metals, 187",{},{"id":19,"text":774,"url":19,"identifiers":775},"10.1097\u002F00043764-197811000-00006",{"doi":774},{"id":19,"text":777,"url":19,"identifiers":778},"10.1002\u002Fajim.4700010211",{"doi":777},{"id":19,"text":780,"url":19,"identifiers":781},"10.1002\u002Fajim.4700030216",{"doi":780},{"id":19,"text":783,"url":19,"identifiers":784},"10.1016\u002F0165-1161(80)90060-6",{"doi":783},{"id":19,"text":786,"url":19,"identifiers":787},"Valadaud‐Barrieu D, 1979, Action de la phase gazeuse de fumée de cigarette sur le taux d'échanges des chromatides‐soeurs du lymphocyte humain in vitro, CR Acad Se (Paris), 288, 899",{},{"id":19,"text":789,"url":19,"identifiers":790},"10.1016\u002F0027-5107(82)90234-2",{"doi":789},{"id":19,"text":792,"url":19,"identifiers":793},"10.1111\u002Fj.1399-0004.1981.tb01056.x",{"doi":792},{"id":19,"text":795,"url":19,"identifiers":796},"10.1007\u002FBF00377457",{"doi":795},{"id":19,"text":798,"url":19,"identifiers":799},"10.2486\u002Findhealth.19.37",{"doi":798},{"id":19,"text":801,"url":19,"identifiers":802},"WatanabeT.KasukawaT.EndoA(1983):Sister chromatid exchanges in lymphocytes from cigarette smokers. Jpn J Hum Genet (Abstr) 28 (in press).",{},{"id":804,"createTime":805,"updateTime":805,"relativeEntities":806,"slug":807,"properties":808,"entityType":47,"verifyStatus":48,"verifyTime":805,"verifyNote":49,"languages":821,"translateLanguages":19,"viewCount":20,"primaryUrl":822,"fullTextUrl":19,"authors":823,"publicationType":143,"publisherRelationship":890,"citationCount":906,"citationInfo":907,"publishDate":910,"publishYear":908,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":911,"openAccess":19,"references":912,"isForceReanalyzing":262},"7ca9044f-12fd-4d1e-a468-28c2fa4752aa","2024-12-26T05:26:41.290+00:00",[],"Comparative-cytogenetic-analysis-of-bone-marrow-damage-induced-in-male-B6C3F1-mice-by-multiple-exposures-to-gaseous-1-3-butadiene",{"openalex":809,"mag":811,"abstract":813,"title":815,"pm":817,"doi":819},{"VOID":810},"W1994752319",{"VOID":812},"1994752319",{"EN":814},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Groups of male B6C3F1 mice (N = 12) were exposed to ambient air or to gaseous 1,3‐butadiene (BD) at 6.25, 62.5, and 625 ppm for 10 exposure days (6 hr + T\u003Cjats:sub>90\u003C\u002Fjats:sub>\u002Fday). Exposure to BD induced in bone marrow: 1) a significant increase in the frequency of chromosomal aberrations (CA); 2) a significant elevation in the frequency of sister chromatid exchanges (SCE); 3) a significant lengthening of the average generation time (AGT); 4) a significant depression in the mitotic index (MI); and, as measured in the peripheral blood, 5) a significant increase in the proportion of circulating polychromatic erythrocytes (%PCE), and 6) a significant increase in the level of micronucleated PCE (MN‐PCE) and micronucleated normochromatic erythrocytes (MN‐NCE). The most sensitive indicator of genotoxic damage was the frequency of SCE (significant at 6.25 ppm), followed by MN‐PCE levels (significant at 62.5 ppm), and then by CA and MN‐NCE frequencies (significant at 625 ppm). The most sensitive measure of cytotoxic damage was AGT (significant at 62.5 ppm), followed by %PCE (significant at 625 ppm), and then by MI (significant by trend test only). Because each cytogenetic endpoint was evaluated in every animal, a correlation analysis was conducted to evaluate the degree of concordance among the various indicators of genotoxic and cytotoxic damage. The extent of concordance ranged from a very good correlation between the induction of MN‐PCE and the induction of SCE (correlation coefficient r = 0.9562) to the lack of a significant correlation between the depression in the MI and any other endpoint (r < 0.37).\u003C\u002Fjats:p>",{"EN":816},"Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3‐butadiene",{"VOID":818},"3569168",{"VOID":820},"10.1002\u002Fem.2860090303",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860090303",[824,841,858,873],{"id":825,"sortIndex":20,"researcher":19,"roles":826,"affiliations":827,"properties":836,"displayName":838,"givenName":19,"familyName":19},"849284de-01aa-4cb7-bc0f-0d526da770c0",[],[828],{"id":829,"sortIndex":20,"affiliation":830,"properties":19},"74985163-8717-400e-bea0-ade68dedc37e",{"id":829,"createTime":19,"updateTime":19,"relativeEntities":831,"slug":19,"properties":832,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":835,"statistic":19},[],{"title":833},{"VI":834},"Medical Department, Brookhaven National Laboratory, Upton, NY 11973",[],{"title":837,"openalex":839},{"EN":838},"Raymond R. Tice",{"VOID":840},"A5111817326",{"id":842,"sortIndex":73,"researcher":19,"roles":843,"affiliations":844,"properties":853,"displayName":855,"givenName":19,"familyName":19},"4c709004-2827-4d8c-bc10-0d80bd28eaaa",[],[845],{"id":846,"sortIndex":20,"affiliation":847,"properties":19},"222405b3-b87a-4469-880e-9e3974a69eba",{"id":846,"createTime":19,"updateTime":19,"relativeEntities":848,"slug":19,"properties":849,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":852,"statistic":19},[],{"title":850},{"VI":851},"Medical Department, Brookhaven National Laboratory, Upton, New York",[],{"title":854,"openalex":856},{"EN":855},"Raymond Boucher",{"VOID":857},"A5006275295",{"id":859,"sortIndex":89,"researcher":19,"roles":860,"affiliations":861,"properties":868,"displayName":870,"givenName":19,"familyName":19},"932a0e36-8c38-4d35-aea6-af67b70dea13",[],[862],{"id":846,"sortIndex":20,"affiliation":863,"properties":19},{"id":846,"createTime":19,"updateTime":19,"relativeEntities":864,"slug":19,"properties":865,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":867,"statistic":19},[],{"title":866},{"VI":851},[],{"title":869,"openalex":871},{"EN":870},"Carol A. Luke",{"VOID":872},"A5083080917",{"id":874,"sortIndex":109,"researcher":19,"roles":875,"affiliations":876,"properties":885,"displayName":887,"givenName":19,"familyName":19},"9f4c4a7a-545b-41af-b82d-aa5bcecdcb6c",[],[877],{"id":878,"sortIndex":20,"affiliation":879,"properties":19},"a72a27b9-585e-47a3-ba6c-69867047dc5c",{"id":878,"createTime":19,"updateTime":19,"relativeEntities":880,"slug":19,"properties":881,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":884,"statistic":19},[],{"title":882},{"EN":883},"National Toxicology Program , NIEHS , Research Triangle Park, North Carolina",[],{"title":886,"openalex":888},{"EN":887},"Michael D. Shelby",{"VOID":889},"A5027953355",{"url":19,"publisher":891,"properties":900},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":892,"slug":10,"properties":893,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":897,"manageAffiliations":898,"indexDatabases":899,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":894,"title":895,"eissn":896},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":901,"pages":902,"volume":904},{"VOID":417},{"VOID":903},"235-250",{"VOID":905},"9",153,{"total":906,"publishYear":908,"statisticByYear":909},1987,{"2012":89,"2013":89,"2015":73,"2016":89,"2017":73,"2018":73,"2019":73,"2021":73,"2023":73},"1987-01-01",[],[913,916,919,922,924,927,930,933,936,939,942,945,948,951,954,957,960,963,966,968,971,974,977,980,983,985,988,991,994,996,998,1000,1004,1007,1010,1013],{"id":19,"text":914,"url":19,"identifiers":915},"10.1016\u002F0024-3205(69)90020-4",{"doi":914},{"id":19,"text":917,"url":19,"identifiers":918},"10.1016\u002F0041-008X(86)90268-1",{"doi":917},{"id":19,"text":920,"url":19,"identifiers":921},"Choy W‐N, 1986, Genotoxicity of 1,3‐butadiene. Induction of bone marrow micronuclei in B6C3F1 mice and Sprague‐Dawley rats in vivo, Environ Mutagen, 8, 18",{},{"id":19,"text":445,"url":19,"identifiers":923},{"doi":445},{"id":19,"text":925,"url":19,"identifiers":926},"Cunningham MJ, 1986, Genotoxicity of 1,3‐butadiene. Induction of sister chromatid exchanges in B6C3F1 mice and Sprague‐Dawley rats, Environ Mutagen, 8, 20",{},{"id":19,"text":928,"url":19,"identifiers":929},"10.1016\u002F0378-4274(80)90179-4",{"doi":928},{"id":19,"text":931,"url":19,"identifiers":932},"10.1007\u002FBF00329173",{"doi":931},{"id":19,"text":934,"url":19,"identifiers":935},"10.1016\u002F0027-5107(84)90014-9",{"doi":934},{"id":19,"text":937,"url":19,"identifiers":938},"Hazleton Laboratories Europe(1981):1 3‐Butadiene. Inhalation Teratogenicity Study in the Rat. Final Report and Addendum No. 2788‐522\u002F3. Hazleton Labs Harrowgate HG3 IPY UK.",{},{"id":19,"text":940,"url":19,"identifiers":941},"10.1016\u002F0165-1110(83)90047-7",{"doi":940},{"id":19,"text":943,"url":19,"identifiers":944},"10.1126\u002Fscience.3966163",{"doi":943},{"id":19,"text":946,"url":19,"identifiers":947},"10.1016\u002F0041-008X(86)90326-1",{"doi":946},{"id":19,"text":949,"url":19,"identifiers":950},"10.1016\u002F0041-008X(86)90352-2",{"doi":949},{"id":19,"text":952,"url":19,"identifiers":953},"Ivett JL, 1982, Average generation time: A new method for analyzing cellular proliferation kinetics based on bromodeoxyuridine‐dependent chromosomal differential staining patterns, Environ Mutagen, 4, 358",{},{"id":19,"text":955,"url":19,"identifiers":956},"10.1080\u002F09553008214550171",{"doi":955},{"id":19,"text":958,"url":19,"identifiers":959},"10.1038\u002F251070a0",{"doi":958},{"id":19,"text":961,"url":19,"identifiers":962},"Kirk‐Othmen Encyclopedia of Chemical Technology, 1979, Butadiene, 313",{},{"id":19,"text":964,"url":19,"identifiers":965},"10.1016\u002F0378-4274(86)90095-0",{"doi":964},{"id":19,"text":460,"url":19,"identifiers":967},{"doi":460},{"id":19,"text":969,"url":19,"identifiers":970},"10.1016\u002F0014-4800(86)90032-8",{"doi":969},{"id":19,"text":972,"url":19,"identifiers":973},"Luke CA, 1985, Duration and regimen induced micronuclei in the peripheral blood of mice exposed chronically to benzene, Environ Mutagen, 7, 29",{},{"id":19,"text":975,"url":19,"identifiers":976},"10.1002\u002Fem.2860020408",{"doi":975},{"id":19,"text":978,"url":19,"identifiers":979},"Margolin BH, 1986, Evaluation of Short‐Term Tests for Carcinogens: Report of the International Programme on Chemical Safety's Collaborative Study on In Vivo Assays",{},{"id":19,"text":981,"url":19,"identifiers":982},"10.1002\u002Fem.2860080203",{"doi":981},{"id":19,"text":481,"url":19,"identifiers":984},{"doi":481},{"id":19,"text":986,"url":19,"identifiers":987},"10.1016\u002F0027-5107(82)90241-X",{"doi":986},{"id":19,"text":989,"url":19,"identifiers":990},"10.1007\u002F978-3-642-67729-8_14",{"doi":989},{"id":19,"text":992,"url":19,"identifiers":993},"10.1016\u002F0165-1110(81)90030-0",{"doi":992},{"id":19,"text":517,"url":19,"identifiers":995},{"doi":517},{"id":19,"text":523,"url":19,"identifiers":997},{"doi":523},{"id":19,"text":280,"url":19,"identifiers":999},{"doi":280},{"id":19,"text":1001,"url":19,"identifiers":1002},"ThurmondLM LauerLD HouseRV StillmanWS IronsRD SteinhagenWH DeanJW(1986):Effect of short‐term inhalation exposure to 1 3‐butadiene on murine immune functions. Toxicol Applied Pharmacol (in press).",{"doi":1003},"10.1016\u002F0041-008X(86)90047-5",{"id":19,"text":1005,"url":19,"identifiers":1006},"10.1016\u002F0165-1218(78)90022-8",{"doi":1005},{"id":19,"text":1008,"url":19,"identifiers":1009},"Tice RR, 1985, Toxicology of the Blood and Bone Marrow, 119",{},{"id":19,"text":1011,"url":19,"identifiers":1012},"TiceRR LukeCA ShelbyMD(1986):Methyl isocyanate: An evaluation of in vivo cytogenetic activity. Environ Mutagen (in press).",{},{"id":19,"text":1014,"url":19,"identifiers":1015},"10.1016\u002F0014-4827(76)90037-9",{"doi":1014},{"id":1017,"createTime":1018,"updateTime":1018,"relativeEntities":1019,"slug":1020,"properties":1021,"entityType":47,"verifyStatus":48,"verifyTime":1018,"verifyNote":49,"languages":1034,"translateLanguages":19,"viewCount":20,"primaryUrl":1035,"fullTextUrl":19,"authors":1036,"publicationType":143,"publisherRelationship":1088,"citationCount":1105,"citationInfo":1106,"publishDate":1110,"publishYear":1107,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":1111,"openAccess":19,"references":1112,"isForceReanalyzing":262},"cdae2432-e4ab-4b9e-bc33-e08d5abec798","2024-12-06T07:46:13.606+00:00",[],"The-genetic-toxicology-of-metal-compounds-I-Induction-of-%CE%BB-prophage-in-i-E-coli-i-WP2-sub-S-sub-%CE%BB-",{"openalex":1022,"mag":1024,"abstract":1026,"title":1028,"pm":1030,"doi":1032},{"VOID":1023},"W2060211227",{"VOID":1025},"2060211227",{"EN":1027},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>A number of metal compounds have been shown to be human carcinogens. Others, while not proven human carcinogens, are able to cause tumors in laboratory animals. Short‐term bacterial assays for genotoxic effects have not been successful in predicting the carcinogenicity of metal compounds. We report here the ability of some metal compounds to cause the induction of λ prophage in \u003Cjats:italic>E coli\u003C\u002Fjats:italic> WP2\u003Cjats:sub>S\u003C\u002Fjats:sub>(λ). By far the strongest inducing ability was observed with K2CrO4, followed by Pb(N0\u003Cjats:sub>3\u003C\u002Fjats:sub>)\u003Cjats:sub>2\u003C\u002Fjats:sub> > MnCl\u003Cjats:sub>2\u003C\u002Fjats:sub> > Ni(OOCCH\u003Cjats:sub>3\u003C\u002Fjats:sub>)\u003Cjats:sub>2\u003C\u002Fjats:sub> > CrCl\u003Cjats:sub>2\u003C\u002Fjats:sub> > NaWO\u003Cjats:sub>4\u003C\u002Fjats:sub> > Na\u003Cjats:sub>2\u003C\u002Fjats:sub>MoO\u003Cjats:sub>4\u003C\u002Fjats:sub> > KMnO\u003Cjats:sub>4\u003C\u002Fjats:sub>. With the exception of chromate, long‐term exposures in a narrow, subtoxic dose range were required in order to demonstrate phage induction. A new microtiter assay for λ prophage induction, which incorporates these features, is described. This system also was able to detect very small amounts of organic carcinogens.\u003C\u002Fjats:p>",{"EN":1029},"The genetic toxicology of metal compounds: I. Induction of λ prophage in \u003Ci>E coli\u003C\u002Fi> WP2\u003Csub>S\u003C\u002Fsub>(λ)",{"VOID":1031},"6229401",{"VOID":1033},"10.1002\u002Fem.2860060108",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860060108",[1037,1056,1073],{"id":1038,"sortIndex":20,"researcher":19,"roles":1039,"affiliations":1040,"properties":1049,"displayName":1053,"givenName":19,"familyName":19},"c9e4ea5a-2fe4-449e-bfda-58f7d9926ef6",[],[1041],{"id":1042,"sortIndex":20,"affiliation":1043,"properties":19},"926164a3-25bb-451b-8549-ab69b29a2f73",{"id":1042,"createTime":19,"updateTime":19,"relativeEntities":1044,"slug":19,"properties":1045,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1048,"statistic":19},[],{"title":1046},{"EN":1047},"Dept. of Environmental Medicines, NYU Medical Center, 550 First Ave., New York, NY 10016",[],{"orcid":1050,"title":1052,"openalex":1054},{"VOID":1051},"https:\u002F\u002Forcid.org\u002F0000-0002-6767-7097",{"EN":1053},"Toby G. Rossman",{"VOID":1055},"A5075178472",{"id":1057,"sortIndex":73,"researcher":19,"roles":1058,"affiliations":1059,"properties":1068,"displayName":1070,"givenName":19,"familyName":19},"087cbc8b-1437-437a-a24b-534f03d7a062",[],[1060],{"id":1061,"sortIndex":20,"affiliation":1062,"properties":19},"9311a55b-b127-4421-94ab-9ce2a520a37e",{"id":1061,"createTime":19,"updateTime":19,"relativeEntities":1063,"slug":19,"properties":1064,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1067,"statistic":19},[],{"title":1065},{"VI":1066},"Department of Environmental Medicine, New York University Medical Center, New York",[],{"title":1069,"openalex":1071},{"EN":1070},"Margarita Molina",{"VOID":1072},"A5111780289",{"id":1074,"sortIndex":89,"researcher":19,"roles":1075,"affiliations":1076,"properties":1083,"displayName":1085,"givenName":19,"familyName":19},"bad5bcc7-a7b6-4c20-ab02-0062b414949d",[],[1077],{"id":1061,"sortIndex":20,"affiliation":1078,"properties":19},{"id":1061,"createTime":19,"updateTime":19,"relativeEntities":1079,"slug":19,"properties":1080,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1082,"statistic":19},[],{"title":1081},{"VI":1066},[],{"title":1084,"openalex":1086},{"EN":1085},"LeRoy W. Meyer",{"VOID":1087},"A5012966957",{"url":19,"publisher":1089,"properties":1098},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1090,"slug":10,"properties":1091,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":1095,"manageAffiliations":1096,"indexDatabases":1097,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":1092,"title":1093,"eissn":1094},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":1099,"pages":1101,"volume":1103},{"VOID":1100},"1",{"VOID":1102},"59-69",{"VOID":1104},"6",97,{"total":1105,"publishYear":1107,"statisticByYear":1108},1984,{"2012":1109,"2016":73,"2017":73,"2018":73,"2023":73},9,"1984-01-01",[],[1113,1115,1118,1121,1124,1127,1130,1133,1136,1139,1142,1145,1148,1151,1154,1157,1160,1163,1166,1169,1172,1175,1178,1181,1184,1187,1190,1193,1196,1199,1202,1205,1208,1211,1214,1217,1220,1223,1226,1229,1232,1235,1238,1241,1244,1247,1250,1253,1256,1259],{"id":19,"text":171,"url":19,"identifiers":1114},{"doi":171},{"id":19,"text":1116,"url":19,"identifiers":1117},"Casto BC, 1979, Enhancement of viral transformation for evaluation of the carcinogenic or mutagenic potential of inorganic metal salts, Cancer Res, 39, 193",{},{"id":19,"text":1119,"url":19,"identifiers":1120},"10.2307\u002F3429216",{"doi":1119},{"id":19,"text":1122,"url":19,"identifiers":1123},"10.1002\u002Fem.2860010113",{"doi":1122},{"id":19,"text":1125,"url":19,"identifiers":1126},"Flessel CP, 1979, Trace Metals in Health and Disease, 109",{},{"id":19,"text":1128,"url":19,"identifiers":1129},"10.1016\u002F0009-2797(81)90077-6",{"doi":1128},{"id":19,"text":1131,"url":19,"identifiers":1132},"10.1007\u002F978-1-4684-0796-9_1",{"doi":1131},{"id":19,"text":1134,"url":19,"identifiers":1135},"10.1016\u002F0165-1161(76)90077-7",{"doi":1134},{"id":19,"text":1137,"url":19,"identifiers":1138},"10.1016\u002F0006-291X(78)90931-2",{"doi":1137},{"id":19,"text":1140,"url":19,"identifiers":1141},"10.1007\u002F978-1-4615-8966-2_8",{"doi":1140},{"id":19,"text":1143,"url":19,"identifiers":1144},"10.1007\u002FBF02783843",{"doi":1143},{"id":19,"text":1146,"url":19,"identifiers":1147},"10.1289\u002Fehp.8140143",{"doi":1146},{"id":19,"text":1149,"url":19,"identifiers":1150},"10.2307\u002F3429224",{"doi":1149},{"id":19,"text":1152,"url":19,"identifiers":1153},"10.1021\u002Fbi00533a030",{"doi":1152},{"id":19,"text":1155,"url":19,"identifiers":1156},"10.1016\u002F0027-5107(77)90153-1",{"doi":1155},{"id":19,"text":1158,"url":19,"identifiers":1159},"10.1073\u002Fpnas.79.23.7445",{"doi":1158},{"id":19,"text":1161,"url":19,"identifiers":1162},"Lofroth G, 1978, Mutagenicity of inorganic compounds in Salmonella typhimurium: arsenic, chromium and selinium. Mutat, Res, 53, 65",{},{"id":19,"text":1164,"url":19,"identifiers":1165},"10.1002\u002Fem.2860030404",{"doi":1164},{"id":19,"text":1167,"url":19,"identifiers":1168},"10.1016\u002F0165-1110(81)90032-4",{"doi":1167},{"id":19,"text":1170,"url":19,"identifiers":1171},"10.1073\u002Fpnas.73.10.3700",{"doi":1170},{"id":19,"text":1173,"url":19,"identifiers":1174},"10.1016\u002F0165-1218(78)90007-1",{"doi":1173},{"id":19,"text":1176,"url":19,"identifiers":1177},"10.1016\u002F0165-1218(79)90046-6",{"doi":1176},{"id":19,"text":1179,"url":19,"identifiers":1180},"10.1016\u002F0165-1161(75)90088-6",{"doi":1179},{"id":19,"text":1182,"url":19,"identifiers":1183},"10.1289\u002Fehp.8140121",{"doi":1182},{"id":19,"text":1185,"url":19,"identifiers":1186},"10.1080\u002F15287398209530170",{"doi":1185},{"id":19,"text":1188,"url":19,"identifiers":1189},"10.1289\u002Fehp.814093",{"doi":1188},{"id":19,"text":1191,"url":19,"identifiers":1192},"10.1016\u002F0165-1218(78)90006-X",{"doi":1191},{"id":19,"text":1194,"url":19,"identifiers":1195},"10.1289\u002Fehp.8140107",{"doi":1194},{"id":19,"text":1197,"url":19,"identifiers":1198},"10.1016\u002F0165-1110(82)90031-8",{"doi":1197},{"id":19,"text":1200,"url":19,"identifiers":1201},"Radman M, 1974, Molecular Mechanisms for Repair of DNA, 355",{},{"id":19,"text":1203,"url":19,"identifiers":1204},"10.1016\u002F0304-3835(82)90073-8",{"doi":1203},{"id":19,"text":1206,"url":19,"identifiers":1207},"10.1016\u002F0027-5107(76)90074-9",{"doi":1206},{"id":19,"text":1209,"url":19,"identifiers":1210},"10.2307\u002F3429232",{"doi":1209},{"id":19,"text":1212,"url":19,"identifiers":1213},"10.1016\u002F0165-7992(81)90032-4",{"doi":1212},{"id":19,"text":1215,"url":19,"identifiers":1216},"10.1016\u002FS0300-9084(82)80134-X",{"doi":1215},{"id":19,"text":1218,"url":19,"identifiers":1219},"Sidgwick NV, 1950, The Chemical Elements and Their Compounds, 1272",{},{"id":19,"text":1221,"url":19,"identifiers":1222},"10.2307\u002F3429229",{"doi":1221},{"id":19,"text":1224,"url":19,"identifiers":1225},"10.1126\u002Fscience.1006310",{"doi":1224},{"id":19,"text":1227,"url":19,"identifiers":1228},"10.1073\u002Fpnas.75.1.410",{"doi":1227},{"id":19,"text":1230,"url":19,"identifiers":1231},"10.1016\u002F0165-1161(78)90140-1",{"doi":1230},{"id":19,"text":1233,"url":19,"identifiers":1234},"10.1016\u002F0027-5107(81)90146-9",{"doi":1233},{"id":19,"text":1236,"url":19,"identifiers":1237},"10.1016\u002F0027-5107(82)90280-9",{"doi":1236},{"id":19,"text":1239,"url":19,"identifiers":1240},"10.1289\u002Fehp.8140131",{"doi":1239},{"id":19,"text":1242,"url":19,"identifiers":1243},"10.1016\u002F0165-1161(78)90422-3",{"doi":1242},{"id":19,"text":1245,"url":19,"identifiers":1246},"Tsapakis MJ, 1981, The carcinogen chromate induces DNA cross‐links in rat liver and kidney, J Biol Chem, 256, 2623k‐2626",{},{"id":19,"text":1248,"url":19,"identifiers":1249},"10.2307\u002F3429230",{"doi":1248},{"id":19,"text":1251,"url":19,"identifiers":1252},"10.1038\u002F250493a0",{"doi":1251},{"id":19,"text":1254,"url":19,"identifiers":1255},"10.1016\u002F0009-2797(79)90030-9",{"doi":1254},{"id":19,"text":1257,"url":19,"identifiers":1258},"10.1128\u002FMMBR.40.4.869-907.1976",{"doi":1257},{"id":19,"text":1260,"url":19,"identifiers":1261},"Zakour RA, 1981, Metal‐induced infidelity of DNA synthesis, Environ Health Perspect, 40, 197, 10.1289\u002Fehp.8140197",{"doi":1262},"10.1289\u002Fehp.8140197",{"id":1264,"createTime":1265,"updateTime":1265,"relativeEntities":1266,"slug":1267,"properties":1268,"entityType":47,"verifyStatus":48,"verifyTime":1281,"verifyNote":49,"languages":1282,"translateLanguages":19,"viewCount":20,"primaryUrl":1283,"fullTextUrl":19,"authors":1284,"publicationType":143,"publisherRelationship":1349,"citationCount":1365,"citationInfo":1366,"publishDate":1369,"publishYear":1367,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":1370,"openAccess":19,"references":1371,"isForceReanalyzing":262},"eca82655-379b-4d51-98d4-dfd002bf8b4c","2024-10-07T07:42:50.289+00:00",[],"Variation-in-the-baseline-sister-chromatid-exchange-frequency-in-human-lymphocytes",{"openalex":1269,"mag":1271,"abstract":1273,"title":1275,"pm":1277,"doi":1279},{"VOID":1270},"W2016202499",{"VOID":1272},"2016202499",{"EN":1274},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The utility of the sister chromatid exchange (SCE) assay for human population studies is potentially limited by the variability associated with individual baseline SCE frequencies. This investigation identifies and quantifies the major sources of preparative and biological variation associated with the determination of baseline SCE frequencies in cultured human lymphocytes. Much of the variation in lymphocyte SCE frequencies is attributable to the amount of bromodeoxyuridine (BrdUrd) available per lymphocyte; the pooled coefficient of variation (CV) over the dose range of 10 to 160 μM is about 18%. Other variations in the baseline frequency result from culture‐to‐culture and slide‐to‐slide differences. The pooled coefficient of variation among donors is about 10%. The effect of cell‐to‐cell differences in baseline SCE frequency among donors can be minimized by increasing the number of cells scored per donor. When 20 cells are analyzed per individual the pooled cell‐to‐cell variation is 9% but when 40 or 80 cells are analyzed it is reduced to 6 and 4% respectively. For a single individual the cell‐to‐cell coefficient of variation at 100 μM BrdUrd is 40.8%. Under our experimental conditions, a 30% increase in SCE frequency between two cohort populations can be detected with a 95% probability at a 5% level of significance when 11 individuals per cohort are studied. For a longitudinal or in vitro dose response study of a single individual, a 50% increase in SCE frequency can be detected with a 95% probability at a 5% level of significance when 25 cells per sample are analyzed. These results indicate the feasibility of applying the SCE bioassay to humans as a measure of environmental stress.\u003C\u002Fjats:p>",{"EN":1276},"Variation in the baseline sister chromatid exchange frequency in human lymphocytes",{"VOID":1278},"7318781",{"VOID":1280},"10.1002\u002Fem.2860020303","2024-10-07T07:42:50.288+00:00",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860020303",[1285,1302,1317,1332],{"id":1286,"sortIndex":20,"researcher":19,"roles":1287,"affiliations":1288,"properties":1297,"displayName":1299,"givenName":19,"familyName":19},"c878d84a-30da-4e27-ba6e-e090417550e2",[],[1289],{"id":1290,"sortIndex":20,"affiliation":1291,"properties":19},"0aaabe56-3754-4bc7-83ca-526fe5ee6f12",{"id":1290,"createTime":19,"updateTime":19,"relativeEntities":1292,"slug":19,"properties":1293,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1296,"statistic":19},[],{"title":1294},{"EN":1295},"Lawrence Livermore Laboratory, Biomedical Sciences Division, University of California, Livermore",[],{"title":1298,"openalex":1300},{"EN":1299},"A.V. Carrano",{"VOID":1301},"A5031903020",{"id":1303,"sortIndex":73,"researcher":19,"roles":1304,"affiliations":1305,"properties":1312,"displayName":1314,"givenName":19,"familyName":19},"fd9af263-40d1-4b34-a11b-7d24e3e6ea04",[],[1306],{"id":1290,"sortIndex":20,"affiliation":1307,"properties":19},{"id":1290,"createTime":19,"updateTime":19,"relativeEntities":1308,"slug":19,"properties":1309,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1311,"statistic":19},[],{"title":1310},{"EN":1295},[],{"title":1313,"openalex":1315},{"EN":1314},"J.L. Minkler",{"VOID":1316},"A5029872592",{"id":1318,"sortIndex":89,"researcher":19,"roles":1319,"affiliations":1320,"properties":1327,"displayName":1329,"givenName":19,"familyName":19},"c8315f5e-60b3-40d0-a56b-104f6e3c14a0",[],[1321],{"id":1290,"sortIndex":20,"affiliation":1322,"properties":19},{"id":1290,"createTime":19,"updateTime":19,"relativeEntities":1323,"slug":19,"properties":1324,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1326,"statistic":19},[],{"title":1325},{"EN":1295},[],{"title":1328,"openalex":1330},{"EN":1329},"Daniel G. Stetka",{"VOID":1331},"A5078118661",{"id":1333,"sortIndex":109,"researcher":19,"roles":1334,"affiliations":1335,"properties":1342,"displayName":1346,"givenName":19,"familyName":19},"e34f0f03-798e-496f-b127-af83429be978",[],[1336],{"id":1290,"sortIndex":20,"affiliation":1337,"properties":19},{"id":1290,"createTime":19,"updateTime":19,"relativeEntities":1338,"slug":19,"properties":1339,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1341,"statistic":19},[],{"title":1340},{"EN":1295},[],{"orcid":1343,"title":1345,"openalex":1347},{"VOID":1344},"https:\u002F\u002Forcid.org\u002F0000-0002-5860-0127",{"EN":1346},"Dan H. Moore",{"VOID":1348},"A5059617881",{"url":19,"publisher":1350,"properties":1359},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1351,"slug":10,"properties":1352,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":1356,"manageAffiliations":1357,"indexDatabases":1358,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":1353,"title":1354,"eissn":1355},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":1360,"pages":1361,"volume":1363},{"VOID":417},{"VOID":1362},"325-337",{"VOID":1364},"2",101,{"total":1365,"publishYear":1367,"statisticByYear":1368},1980,{"2018":73},"1980-01-01",[],[1372,1375,1378,1381,1384,1387,1390,1393,1396,1399,1402,1405,1408,1411,1414,1417,1420,1423,1426,1429,1432,1435,1437,1439,1442,1445,1448,1452,1454],{"id":19,"text":1373,"url":19,"identifiers":1374},"10.1093\u002Fjnci\u002F58.6.1635",{"doi":1373},{"id":19,"text":1376,"url":19,"identifiers":1377},"Alhadeff B, 1976, Frequency and distribution of sister chromatid exchanges in human peripheral lymphocytes, Israel J Med Sci, 12, 1440",{},{"id":19,"text":1379,"url":19,"identifiers":1380},"10.1159\u002F000130765",{"doi":1379},{"id":19,"text":1382,"url":19,"identifiers":1383},"10.1038\u002F271551a0",{"doi":1382},{"id":19,"text":1385,"url":19,"identifiers":1386},"10.1016\u002F0027-5107(79)90114-3",{"doi":1385},{"id":19,"text":1388,"url":19,"identifiers":1389},"10.1007\u002FBF00446625",{"doi":1388},{"id":19,"text":1391,"url":19,"identifiers":1392},"Crossen PE, 1978, Cytogenetic studies of pesticide and herbicide sprayers, New Zealand Med J, 88, 192",{},{"id":19,"text":1394,"url":19,"identifiers":1395},"10.1016\u002F0014-4827(79)90171-X",{"doi":1394},{"id":19,"text":1397,"url":19,"identifiers":1398},"10.1016\u002FS0140-6736(77)91485-4",{"doi":1397},{"id":19,"text":1400,"url":19,"identifiers":1401},"10.1016\u002F0027-5107(77)90144-0",{"doi":1400},{"id":19,"text":1403,"url":19,"identifiers":1404},"10.1111\u002Fj.1601-5223.1976.tb01582.x",{"doi":1403},{"id":19,"text":1406,"url":19,"identifiers":1407},"Lambert B, 1978, Sister chromatid exchanges in lymphocyte cultures of patients receiving chemotherapy for malignant disorders, Cancer Treatment Rpts, 62, 1413",{},{"id":19,"text":1409,"url":19,"identifiers":1410},"10.1073\u002Fpnas.70.12.3395",{"doi":1409},{"id":19,"text":1412,"url":19,"identifiers":1413},"Latt SA, 1977, Population Cytogenetics: Studies in Humans, 217",{},{"id":19,"text":1415,"url":19,"identifiers":1416},"10.1016\u002F0165-1218(79)90020-X",{"doi":1415},{"id":19,"text":1418,"url":19,"identifiers":1419},"10.1016\u002F0014-4827(78)90423-8",{"doi":1418},{"id":19,"text":1421,"url":19,"identifiers":1422},"Minkler J, 1978, An ultraviolet light source for consistent differential staining of sister chromatids, Stain Technol, 53, 359",{},{"id":19,"text":1424,"url":19,"identifiers":1425},"10.1007\u002FBF00402152",{"doi":1424},{"id":19,"text":1427,"url":19,"identifiers":1428},"10.1016\u002FS0027-5107(77)80032-8",{"doi":1427},{"id":19,"text":1430,"url":19,"identifiers":1431},"10.1016\u002F0165-1218(79)90023-5",{"doi":1430},{"id":19,"text":1433,"url":19,"identifiers":1434},"10.1016\u002F0027-5107(78)90275-0",{"doi":1433},{"id":19,"text":762,"url":19,"identifiers":1436},{"doi":762},{"id":19,"text":505,"url":19,"identifiers":1438},{"doi":505},{"id":19,"text":1440,"url":19,"identifiers":1441},"10.1016\u002F0027-5107(78)90274-9",{"doi":1440},{"id":19,"text":1443,"url":19,"identifiers":1444},"10.1016\u002F0027-5107(76)90106-8",{"doi":1443},{"id":19,"text":1446,"url":19,"identifiers":1447},"10.1016\u002F0027-5107(78)90126-4",{"doi":1446},{"id":19,"text":1449,"url":19,"identifiers":1450},"Taylor JH, 1958, Sister chromatid exchanges in tritium‐labeled chromosomes, Genetics, 43, 515, 10.1093\u002Fgenetics\u002F43.3.515",{"doi":1451},"10.1093\u002Fgenetics\u002F43.3.515",{"id":19,"text":1014,"url":19,"identifiers":1453},{"doi":1014},{"id":19,"text":1455,"url":19,"identifiers":1456},"10.1007\u002FBF00290991",{"doi":1455},{"id":1458,"createTime":1459,"updateTime":1459,"relativeEntities":1460,"slug":1461,"properties":1462,"entityType":47,"verifyStatus":48,"verifyTime":1459,"verifyNote":49,"languages":1475,"translateLanguages":19,"viewCount":20,"primaryUrl":1476,"fullTextUrl":19,"authors":1477,"publicationType":143,"publisherRelationship":1563,"citationCount":1579,"citationInfo":1580,"publishDate":1583,"publishYear":1581,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":1584,"openAccess":19,"references":1585,"isForceReanalyzing":262},"414eb0be-6508-4936-9628-a134e2467ca8","2024-10-07T07:42:45.235+00:00",[],"Ethylene-oxide-Evidence-of-human-chromosomal-effects",{"openalex":1463,"mag":1465,"abstract":1467,"title":1469,"pm":1471,"doi":1473},{"VOID":1464},"W2144912555",{"VOID":1466},"2144912555",{"EN":1468},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were employed. All persons whose work activities involved some aspect of the sterilization process were considered exposed to the gas. Within this group of symptomatic and asymptomatic individuals, chronic and incidental exposure was documented by clinical history. Sister chromatid exchanges were studied in lymphocytes cultured from exposed individuals as well as comparable controls. Four chronically exposed persons who reported upper respiratory and neurologic symptoms were studied in some detail. This group showed significantly increased sister chromatid exchange at three weeks and again at eight weeks after the last known exposure. Another group of eight persons with fewer complaints studied as late as the ninth week showed significantly increased exchanges. Incidental exposure may also increase sister chromatid exchange. The measured maximum concentration of ethylene oxide in the sterilizer room was 36 ppm (within standards set by the Occupational Safety and Health Administration).\u003C\u002Fjats:p>",{"EN":1470},"Ethylene oxide: Evidence of human chromosomal effects",{"VOID":1472},"553808",{"VOID":1474},"10.1002\u002Fem.2860010410",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860010410",[1478,1495,1512,1531,1548],{"id":1479,"sortIndex":20,"researcher":19,"roles":1480,"affiliations":1481,"properties":1490,"displayName":1492,"givenName":19,"familyName":19},"378794d4-60eb-464f-b7b1-fd1cd0bfea6a",[],[1482],{"id":1483,"sortIndex":20,"affiliation":1484,"properties":19},"c9b78b53-02e2-45c6-aea6-0ece644d2419",{"id":1483,"createTime":19,"updateTime":19,"relativeEntities":1485,"slug":19,"properties":1486,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1489,"statistic":19},[],{"title":1487},{"EN":1488},"Department of Laboratory Medicine, University of Minnesota, Box 198, Mayo, Minneapolis, MN 55455",[],{"title":1491,"openalex":1493},{"EN":1492},"Vincent F. Garry",{"VOID":1494},"A5030033713",{"id":1496,"sortIndex":73,"researcher":19,"roles":1497,"affiliations":1498,"properties":1507,"displayName":1509,"givenName":19,"familyName":19},"2d3935f4-28a6-461d-89ea-7d7f8aef9aef",[],[1499],{"id":1500,"sortIndex":20,"affiliation":1501,"properties":19},"b08a192d-d451-4dd2-81b4-608fa25e8645",{"id":1500,"createTime":19,"updateTime":19,"relativeEntities":1502,"slug":19,"properties":1503,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1506,"statistic":19},[],{"title":1504},{"VI":1505},"Department of Laboratory Medicine\u002FPathology, University of Minnesota, Minneapolis",[],{"title":1508,"openalex":1510},{"EN":1509},"John Hozier",{"VOID":1511},"A5003065995",{"id":1513,"sortIndex":89,"researcher":19,"roles":1514,"affiliations":1515,"properties":1524,"displayName":1528,"givenName":19,"familyName":19},"88e3df18-c975-4092-a28e-a7012b35834a",[],[1516],{"id":1517,"sortIndex":20,"affiliation":1518,"properties":19},"7b19b9dc-4da5-4a02-9e96-afd02ac201f4",{"id":1517,"createTime":19,"updateTime":19,"relativeEntities":1519,"slug":19,"properties":1520,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1523,"statistic":19},[],{"title":1521},{"EN":1522},"Department of Surgery, Hennepin County Hospital, Minneapolis",[],{"orcid":1525,"title":1527,"openalex":1529},{"VOID":1526},"https:\u002F\u002Forcid.org\u002F0000-0002-7232-0543",{"EN":1528},"David R. Jacobs",{"VOID":1530},"A5051078160",{"id":1532,"sortIndex":109,"researcher":19,"roles":1533,"affiliations":1534,"properties":1543,"displayName":1545,"givenName":19,"familyName":19},"5abaaab3-86b5-4e00-8bbb-b8f07604019d",[],[1535],{"id":1536,"sortIndex":20,"affiliation":1537,"properties":19},"e1a74050-4080-43ca-965c-bee8637e3213",{"id":1536,"createTime":19,"updateTime":19,"relativeEntities":1538,"slug":19,"properties":1539,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1542,"statistic":19},[],{"title":1540},{"EN":1541},"Section of Health Risk Assessment, Minnesota Department of Health, Minneapolis",[],{"title":1544,"openalex":1546},{"EN":1545},"Richard L. Wade",{"VOID":1547},"A5058987600",{"id":1549,"sortIndex":127,"researcher":19,"roles":1550,"affiliations":1551,"properties":1558,"displayName":1560,"givenName":19,"familyName":19},"b05e40a7-0ac6-4d5b-8d3e-5b8d23e3e0bc",[],[1552],{"id":1536,"sortIndex":20,"affiliation":1553,"properties":19},{"id":1536,"createTime":19,"updateTime":19,"relativeEntities":1554,"slug":19,"properties":1555,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1557,"statistic":19},[],{"title":1556},{"EN":1541},[],{"title":1559,"openalex":1561},{"EN":1560},"David G. Gray",{"VOID":1562},"A5036197254",{"url":19,"publisher":1564,"properties":1573},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1565,"slug":10,"properties":1566,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":1570,"manageAffiliations":1571,"indexDatabases":1572,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":1567,"title":1568,"eissn":1569},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":1574,"pages":1576,"volume":1578},{"VOID":1575},"4",{"VOID":1577},"375-382",{"VOID":1100},103,{"total":1579,"publishYear":1581,"statisticByYear":1582},1979,{"2012":109,"2016":73,"2019":73},"1979-01-01",[],[1586,1589,1592,1595,1599,1602,1605,1607,1609,1611,1614,1617,1619,1622,1625,1628,1632,1635,1638,1641,1644,1647,1649,1651,1654,1656,1659,1661,1664,1667,1670],{"id":19,"text":1587,"url":19,"identifiers":1588},"Glaser ZR, 1977, Use of Ethylene Oxide as a Sterilant in Medical Facilities",{},{"id":19,"text":1590,"url":19,"identifiers":1591},"Gross JA, 1978, Ethylene oxide neuropathy, Neurology, 28, 355",{},{"id":19,"text":1593,"url":19,"identifiers":1594},"EhrenbergL HallstronT: Haematologic studies on persons occupationally exposed to ethylene oxide. In: International Agency Report; SM 92\u002F26 1967 pp327–334.",{},{"id":19,"text":1596,"url":19,"identifiers":1597},"Frankel‐Conrat H, 1944, The actions of 1,2‐epoxides on proteins, J Biol Chem, 154, 227, 10.1016\u002FS0021-9258(18)71961-3",{"doi":1598},"10.1016\u002FS0021-9258(18)71961-3",{"id":19,"text":1600,"url":19,"identifiers":1601},"Frankel‐Conrat H, 1961, Chemical modification of viral ribonucleic acid. Part 1. Alkylating agents, Biochem Biophys Acta, 49, 165",{},{"id":19,"text":1603,"url":19,"identifiers":1604},"10.1016\u002F0027-5107(74)90123-7",{"doi":1603},{"id":19,"text":1409,"url":19,"identifiers":1606},{"doi":1409},{"id":19,"text":762,"url":19,"identifiers":1608},{"doi":762},{"id":19,"text":505,"url":19,"identifiers":1610},{"doi":505},{"id":19,"text":1612,"url":19,"identifiers":1613},"10.1016\u002F0014-4827(73)90356-X",{"doi":1612},{"id":19,"text":1615,"url":19,"identifiers":1616},"10.1007\u002FBF00390438",{"doi":1615},{"id":19,"text":1440,"url":19,"identifiers":1618},{"doi":1440},{"id":19,"text":1620,"url":19,"identifiers":1621},"National Institute for Occupational Safety and Health, 1974, NIOSH Manual of Analytical Methods",{},{"id":19,"text":1623,"url":19,"identifiers":1624},"Department of Health, Education, and Welfare, 1977, Occupational Diseases: A Guide to Their Recognition, 203",{},{"id":19,"text":1626,"url":19,"identifiers":1627},"Fujii K, 1969, Carcinogenicity of food additives, pesticides, and drugs, Toxicol Appl Pharmacol, 14, 613",{},{"id":19,"text":1629,"url":19,"identifiers":1630},"Shiraishi Y, 1972, Chromosomal abnormalities in cultured leucocyte cells from Itai Itai disease patients, Proc Jpn Acad, 48, 248, 10.2183\u002Fpjab1945.48.248",{"doi":1631},"10.2183\u002Fpjab1945.48.248",{"id":19,"text":1633,"url":19,"identifiers":1634},"10.1007\u002F978-1-4757-4429-3_3",{"doi":1633},{"id":19,"text":1636,"url":19,"identifiers":1637},"Evans HJ, 1975, Symposium of the Society for the Study of Human Biology, 63",{},{"id":19,"text":1639,"url":19,"identifiers":1640},"Embree JW, 1973, Mutagenicity of ethylene oxide, Toxicol Appl Pharmacol, 33, 172",{},{"id":19,"text":1642,"url":19,"identifiers":1643},"10.1016\u002F0027-5107(77)90206-8",{"doi":1642},{"id":19,"text":1645,"url":19,"identifiers":1646},"Taylor JH, 1958, Sister chromatid exchange in tritium‐labelled chromosomes, Genetics, 43, 515, 10.1093\u002Fgenetics\u002F43.3.515",{"doi":1451},{"id":19,"text":505,"url":19,"identifiers":1648},{"doi":505},{"id":19,"text":1382,"url":19,"identifiers":1650},{"doi":1382},{"id":19,"text":1652,"url":19,"identifiers":1653},"10.1016\u002F0027-5107(78)90064-7",{"doi":1652},{"id":19,"text":1427,"url":19,"identifiers":1655},{"doi":1427},{"id":19,"text":1657,"url":19,"identifiers":1658},"10.1159\u002F000130495",{"doi":1657},{"id":19,"text":1433,"url":19,"identifiers":1660},{"doi":1433},{"id":19,"text":1662,"url":19,"identifiers":1663},"Clinc MJ, 1975, The White Cell, 247",{},{"id":19,"text":1665,"url":19,"identifiers":1666},"10.1016\u002F0014-4827(78)90107-6",{"doi":1665},{"id":19,"text":1668,"url":19,"identifiers":1669},"10.1016\u002F0165-1218(79)90008-9",{"doi":1668},{"id":19,"text":1671,"url":19,"identifiers":1672},"LevinsonC: “Urgent Alert to Blood Cancer Hazard From Ethylene Oxide.” ICEF circular letter No. 97\u002F78. Geneva: International Federation of Chemical Energy and General Worker's Unions 1978.",{},{"id":1674,"createTime":1675,"updateTime":1675,"relativeEntities":1676,"slug":1677,"properties":1678,"entityType":47,"verifyStatus":48,"verifyTime":1675,"verifyNote":49,"languages":1691,"translateLanguages":19,"viewCount":20,"primaryUrl":1692,"fullTextUrl":19,"authors":1693,"publicationType":143,"publisherRelationship":1728,"citationCount":1743,"citationInfo":1744,"publishDate":1747,"publishYear":1745,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":1748,"openAccess":19,"references":1749,"isForceReanalyzing":262},"59d2634b-5a62-4f7f-9c4d-b2e1124480a9","2024-10-07T07:42:42.983+00:00",[],"Sister-chromatid-exchanges-induced-in-rabbit-lymphocytes-by-ethylene-oxide-after-inhalation-exposure",{"openalex":1679,"mag":1681,"abstract":1683,"title":1685,"pm":1687,"doi":1689},{"VOID":1680},"W1967365304",{"VOID":1682},"1967365304",{"EN":1684},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Ethylene oxide, which is the simplest epoxide and an extremely important commercial compound, has been used by many investigators as a model compound to study mutagenicity by alkylation of DNA. Knowledge of in vivo dose‐effect relations under experimental conditions may provide further insight into the dynamics of the sister chromatid exchange (SCE) response. It may also provide information on temporal aspects of sampling design for human worker populations. Groups of four male New Zealand white rabbits were exposed in inhalation chambers to 0, 10, 50, and 250 parts per million (ppm) ethylene oxide for 6 hr a day, 5 days a week, for 12 weeks. Peripheral blood samples were taken before the start of exposure, at intervals during exposure, and up to 15 weeks after the end of exposure to measure SCE rates in peripheral lymphocytes as well as standard hematological endpoints. Additionally, the level of reduced glutathione (GSH) in liver and blood was measured in a set of concurrently exposed animals at the end of the 12‐week exposure. Results show that exposure to 10 ppm does not cause a detectable increase in SCE rates. However, exposure to 50 and 250 ppm does cause an increase in SCEs that decreases after exposure ends, but still remains above baseline levels 15 weeks after exposure. Hematological and GSH measurements did not differ between control and exposed groups. These results indicate that inhalation exposure to the mutagenic alkylating agent ethylene oxide results in a dose‐related SCE effect, and that SCE is a more sensitive indicator of exposure than either standard hematological end points or GSH levels.\u003C\u002Fjats:p>",{"EN":1686},"Sister chromatid exchanges induced in rabbit lymphocytes by ethylene oxide after inhalation exposure",{"VOID":1688},"7075577",{"VOID":1690},"10.1002\u002Fem.2860040204",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860040204",[1694,1711],{"id":1695,"sortIndex":20,"researcher":19,"roles":1696,"affiliations":1697,"properties":1706,"displayName":1708,"givenName":19,"familyName":19},"1ca4016a-4baa-4f2b-a89f-802864ebc9a4",[],[1698],{"id":1699,"sortIndex":20,"affiliation":1700,"properties":19},"9f528da9-23a4-4d61-a903-9e519a54238e",{"id":1699,"createTime":19,"updateTime":19,"relativeEntities":1701,"slug":19,"properties":1702,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1705,"statistic":19},[],{"title":1703},{"VI":1704},"Department of Biomedical and Environmental Health Sciences School of Public Health, University of California, Berkeley",[],{"title":1707,"openalex":1709},{"EN":1708},"Janice W. Yager",{"VOID":1710},"A5103464205",{"id":1712,"sortIndex":73,"researcher":19,"roles":1713,"affiliations":1714,"properties":1723,"displayName":1725,"givenName":19,"familyName":19},"e2cc789c-0a65-4c15-a09d-e3cb45ed9ade",[],[1715],{"id":1716,"sortIndex":20,"affiliation":1717,"properties":19},"5ac1066a-c83f-4e39-89ef-c133157d9bd4",{"id":1716,"createTime":19,"updateTime":19,"relativeEntities":1718,"slug":19,"properties":1719,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1722,"statistic":19},[],{"title":1720},{"EN":1721},"Toxic Hazards Research Unit, University of California, Irvine, at Wright-Patterson AFB, Dayton, Ohio",[],{"title":1724,"openalex":1726},{"EN":1725},"R. Benz",{"VOID":1727},"A5073073925",{"url":19,"publisher":1729,"properties":1738},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1730,"slug":10,"properties":1731,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":1735,"manageAffiliations":1736,"indexDatabases":1737,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":1732,"title":1733,"eissn":1734},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":1739,"pages":1740,"volume":1742},{"VOID":1364},{"VOID":1741},"121-134",{"VOID":1575},42,{"total":1743,"publishYear":1745,"statisticByYear":1746},1982,{"2012":109,"2019":73},"1982-01-01",[],[1750,1752,1755,1758,1760,1762,1765,1768,1771,1774,1777,1779,1782,1785,1788,1791,1795,1797,1799,1802,1805,1808,1811,1814,1817,1819,1822,1825,1828,1831,1833,1836,1838,1840,1843,1846,1848,1850,1853,1856],{"id":19,"text":436,"url":19,"identifiers":1751},{"doi":436},{"id":19,"text":1753,"url":19,"identifiers":1754},"Altman PL, 1974, Biology Data Book",{},{"id":19,"text":1756,"url":19,"identifiers":1757},"Beutler E, 1963, Improved method for the determination of blood glutathione, J Lab Clin Med, 61, 882",{},{"id":19,"text":1382,"url":19,"identifiers":1759},{"doi":1382},{"id":19,"text":1280,"url":19,"identifiers":1761},{"doi":1280},{"id":19,"text":1763,"url":19,"identifiers":1764},"Consolazio FC, 1963, Physiological Measurements of Multiple Functions in Man, 196",{},{"id":19,"text":1766,"url":19,"identifiers":1767},"Crossen PE, 1978, Cytogenetic studies of pesticide and herbicide sprayers, N Zealand Med J, 88, 192",{},{"id":19,"text":1769,"url":19,"identifiers":1770},"10.1080\u002F01621459.1955.10501294",{"doi":1769},{"id":19,"text":1772,"url":19,"identifiers":1773},"10.1016\u002F0165-1110(81)90034-8",{"doi":1772},{"id":19,"text":1775,"url":19,"identifiers":1776},"Ehrenberg L, 1979, Assessing Chemical Mutagens. The Risk to Humans",{},{"id":19,"text":1603,"url":19,"identifiers":1778},{"doi":1603},{"id":19,"text":1780,"url":19,"identifiers":1781},"Ehrenberg L, 1967, Haematologic studies on persons occupationally exposed to ethylene oxide, Int Atomic Energy Agency Report SM, 92, 327",{},{"id":19,"text":1783,"url":19,"identifiers":1784},"10.1111\u002Fj.1601-5223.1957.tb03463.x",{"doi":1783},{"id":19,"text":1786,"url":19,"identifiers":1787},"10.1016\u002F0041-008X(77)90096-5",{"doi":1786},{"id":19,"text":1789,"url":19,"identifiers":1790},"Embree JW, 1975, Mutagenicity of ethylene oxide, Toxicol Appl Pharmacol, 33, 172",{},{"id":19,"text":1792,"url":19,"identifiers":1793},"Fjellstedt TA, 1973, Enzymatic conjugation of epoxides with glutathione, J Biol Chem, 248, 3702, 10.1016\u002FS0021-9258(19)43983-5",{"doi":1794},"10.1016\u002FS0021-9258(19)43983-5",{"id":19,"text":1397,"url":19,"identifiers":1796},{"doi":1397},{"id":19,"text":1474,"url":19,"identifiers":1798},{"doi":1474},{"id":19,"text":1800,"url":19,"identifiers":1801},"Melby EC, 1976, Handbook of Laboratory Animal Science",{},{"id":19,"text":1803,"url":19,"identifiers":1804},"10.1016\u002F0009-2797(76)90042-9",{"doi":1803},{"id":19,"text":1806,"url":19,"identifiers":1807},"10.1007\u002FBF00336584",{"doi":1806},{"id":19,"text":1809,"url":19,"identifiers":1810},"10.1007\u002FBF00336573",{"doi":1809},{"id":19,"text":1812,"url":19,"identifiers":1813},"10.1002\u002Fem.2860030409",{"doi":1812},{"id":19,"text":1815,"url":19,"identifiers":1816},"10.1016\u002F0165-1218(79)90105-8",{"doi":1815},{"id":19,"text":721,"url":19,"identifiers":1818},{"doi":721},{"id":19,"text":1820,"url":19,"identifiers":1821},"Lambert B, 1978, Sister chromatid exchanges in lymphocyte cultures of patients receiving chemotherapy for malignant disorders, Cancer Treatment Rep, 62, 1413",{},{"id":19,"text":1823,"url":19,"identifiers":1824},"LeidelNA BuschKA LynchJR(1977):Occupational exposure sampling strategy manual. NIOSH January 1977 DHEW Publ No 77–173.",{},{"id":19,"text":1826,"url":19,"identifiers":1827},"10.1016\u002F0304-4165(79)90289-7",{"doi":1826},{"id":19,"text":1829,"url":19,"identifiers":1830},"Nakao Y, 1961, Test of a possible correlation between crosslinking and chromosome breaking abilities of chemical mutagens, Z Vererbungsl, 93, 356",{},{"id":19,"text":1433,"url":19,"identifiers":1832},{"doi":1433},{"id":19,"text":1834,"url":19,"identifiers":1835},"10.1007\u002F978-1-4613-3072-1_1",{"doi":1834},{"id":19,"text":762,"url":19,"identifiers":1837},{"doi":762},{"id":19,"text":1440,"url":19,"identifiers":1839},{"doi":1440},{"id":19,"text":1841,"url":19,"identifiers":1842},"10.1016\u002F0041-008X(75)90274-4",{"doi":1841},{"id":19,"text":1844,"url":19,"identifiers":1845},"10.1016\u002F0003-2697(68)90092-4",{"doi":1844},{"id":19,"text":1443,"url":19,"identifiers":1847},{"doi":1443},{"id":19,"text":1446,"url":19,"identifiers":1849},{"doi":1446},{"id":19,"text":1851,"url":19,"identifiers":1852},"Use of ethylene oxide as a sterilant in medical facilities. DHEW (NIOSH) Publ No 77–200 August 1977.",{},{"id":19,"text":1854,"url":19,"identifiers":1855},"10.1016\u002F0300-483X(76)90002-0",{"doi":1854},{"id":19,"text":1857,"url":19,"identifiers":1858},"Weisbroth SH, 1974, The Biology of the Laboratory Rabbit, 57",{},{"id":1860,"createTime":1861,"updateTime":1861,"relativeEntities":1862,"slug":1863,"properties":1864,"entityType":47,"verifyStatus":48,"verifyTime":1861,"verifyNote":49,"languages":1877,"translateLanguages":19,"viewCount":20,"primaryUrl":1878,"fullTextUrl":19,"authors":1879,"publicationType":143,"publisherRelationship":2005,"citationCount":2020,"citationInfo":2021,"publishDate":1110,"publishYear":1107,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":2034,"openAccess":19,"references":2035,"isForceReanalyzing":262},"6bec417e-3bc7-407a-a2f6-c934edbf75e5","2024-10-05T22:30:40.585+00:00",[],"Somatic-mutation-and-recombination-test-in-i-Drosophila-melanogaster-i-",{"openalex":1865,"mag":1867,"abstract":1869,"title":1871,"pm":1873,"doi":1875},{"VOID":1866},"W2126041423",{"VOID":1868},"2126041423",{"EN":1870},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>A novel test system for the detection of mutagenic and recombinogenic activity of chemicals is described in detail. \u003Cjats:italic>Drosophila melanogaster\u003C\u002Fjats:italic> larvae trans‐heterozygous for the mutations multiple wing hairs (mwh) and flare (fir) are exposed to the test compounds for various periods of time ranging from 96 hr to 1 hr. Induced mutations are detected as single mosaic spots on the wing blade of surviving adults that show either the multiple wing hairs or flare phenotype. Induced recombination leads to mwh and fir twin spots and also to a certain extent, to mwh single spots. Recording of the frequency and the size of the different spots allows for a quantitative determination of the mutagenic and recombinogenic effects. This and earlier studies with a small set of well‐known mutagens indicate that the test detects monofunctional and polyfunctional alkylating agents (ethyl methanesulfonate, diepoxybutane, mitomycin C, Trenimon), mutagens forming large adducts (aflatoxin B\u003Cjats:sub>1\u003C\u002Fjats:sub>), DNA breaking agents (bleomycin), intercalating agents (5‐aminoacridine, ICR‐170), spindle poisons (vinblastine), and antimetabolites (methotrexate). In addition, the test detects mutagens unstable in aqueous solution β‐propiolactone), gaseous mutagens (1,2‐dibromoethane), as well as promutagens needing various pathways of metabolic activation (aflatoxin B\u003Cjats:sub>1\u003C\u002Fjats:sub>, diethylnitrosamine, dimethylnitrosamine, mitomycin C, and procarbazine). The rapidity and ease of performance as well as the low costs of the test necessitate a high priority for validation of this promising \u003Cjats:italic>Drosophila\u003C\u002Fjats:italic> short‐term test.\u003C\u002Fjats:p>",{"EN":1872},"Somatic mutation and recombination test in \u003Ci>Drosophila melanogaster\u003C\u002Fi>",{"VOID":1874},"6423380",{"VOID":1876},"10.1002\u002Fem.2860060206",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860060206",[1880,1905,1920,1937,1952,1967,1982],{"id":1881,"sortIndex":20,"researcher":19,"roles":1882,"affiliations":1883,"properties":1900,"displayName":1902,"givenName":19,"familyName":19},"a412d98c-2d7c-444e-8b10-5e6c9920a729",[],[1884,1892],{"id":1885,"sortIndex":20,"affiliation":1886,"properties":19},"078d9987-3dca-4c17-881f-7ef383d693c5",{"id":1885,"createTime":19,"updateTime":19,"relativeEntities":1887,"slug":19,"properties":1888,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1891,"statistic":19},[],{"title":1889},{"VI":1890},"Department of Genetics, University of the Witwatersrand, Johannesburg, South Africa",[],{"id":1893,"sortIndex":73,"affiliation":1894,"properties":19},"149b4eb6-33c4-42c2-802e-d946c3245c52",{"id":1893,"createTime":19,"updateTime":19,"relativeEntities":1895,"slug":19,"properties":1896,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1899,"statistic":19},[],{"title":1897},{"VI":1898},"Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, Schwerzenbach, Switzerland",[],{"title":1901,"openalex":1903},{"EN":1902},"Ulrich Gräf",{"VOID":1904},"A5013421314",{"id":1906,"sortIndex":73,"researcher":19,"roles":1907,"affiliations":1908,"properties":1915,"displayName":1917,"givenName":19,"familyName":19},"8e073c18-9a85-4b67-95d5-e19920b9455a",[],[1909],{"id":1893,"sortIndex":20,"affiliation":1910,"properties":19},{"id":1893,"createTime":19,"updateTime":19,"relativeEntities":1911,"slug":19,"properties":1912,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1914,"statistic":19},[],{"title":1913},{"VI":1898},[],{"title":1916,"openalex":1918},{"EN":1917},"F.E. Würgler",{"VOID":1919},"A5009318870",{"id":1921,"sortIndex":89,"researcher":19,"roles":1922,"affiliations":1923,"properties":1932,"displayName":1934,"givenName":19,"familyName":19},"3e7ef47a-6ec9-46c0-bf02-5e60e44a4f7e",[],[1924],{"id":1925,"sortIndex":20,"affiliation":1926,"properties":19},"f5feab9b-aac1-4293-ba30-c50456c73e1b",{"id":1925,"createTime":19,"updateTime":19,"relativeEntities":1927,"slug":19,"properties":1928,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1931,"statistic":19},[],{"title":1929},{"VI":1930},"Department of Biological Sciences, Illinois State University, Normal, Illinois",[],{"title":1933,"openalex":1935},{"EN":1934},"Alan J. Katz",{"VOID":1936},"A5088805220",{"id":1938,"sortIndex":109,"researcher":19,"roles":1939,"affiliations":1940,"properties":1947,"displayName":1949,"givenName":19,"familyName":19},"1ad736ce-8bfe-42e9-88c6-7015568a52c5",[],[1941],{"id":1893,"sortIndex":20,"affiliation":1942,"properties":19},{"id":1893,"createTime":19,"updateTime":19,"relativeEntities":1943,"slug":19,"properties":1944,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1946,"statistic":19},[],{"title":1945},{"VI":1898},[],{"title":1948,"openalex":1950},{"EN":1949},"H. Frei",{"VOID":1951},"A5013633441",{"id":1953,"sortIndex":127,"researcher":19,"roles":1954,"affiliations":1955,"properties":1962,"displayName":1964,"givenName":19,"familyName":19},"8c750d33-9fe7-4661-b3b6-a725ad5ef2b9",[],[1956],{"id":1893,"sortIndex":20,"affiliation":1957,"properties":19},{"id":1893,"createTime":19,"updateTime":19,"relativeEntities":1958,"slug":19,"properties":1959,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1961,"statistic":19},[],{"title":1960},{"VI":1898},[],{"title":1963,"openalex":1965},{"EN":1964},"H. Juon",{"VOID":1966},"A5065450483",{"id":1968,"sortIndex":373,"researcher":19,"roles":1969,"affiliations":1970,"properties":1977,"displayName":1979,"givenName":19,"familyName":19},"99eec11f-151c-4e20-a465-1e716cdab211",[],[1971],{"id":1885,"sortIndex":20,"affiliation":1972,"properties":19},{"id":1885,"createTime":19,"updateTime":19,"relativeEntities":1973,"slug":19,"properties":1974,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1976,"statistic":19},[],{"title":1975},{"VI":1890},[],{"title":1978,"openalex":1980},{"EN":1979},"Caroline B. Hall",{"VOID":1981},"A5017422744",{"id":1983,"sortIndex":389,"researcher":19,"roles":1984,"affiliations":1985,"properties":2000,"displayName":2002,"givenName":19,"familyName":19},"1b639f70-5af0-47c2-a391-40ca9bebe964",[],[1986,1992],{"id":1893,"sortIndex":20,"affiliation":1987,"properties":19},{"id":1893,"createTime":19,"updateTime":19,"relativeEntities":1988,"slug":19,"properties":1989,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1991,"statistic":19},[],{"title":1990},{"VI":1898},[],{"id":1993,"sortIndex":73,"affiliation":1994,"properties":19},"e472fba5-b8c5-404f-83fc-9434cb4fd1d6",{"id":1993,"createTime":19,"updateTime":19,"relativeEntities":1995,"slug":19,"properties":1996,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":1999,"statistic":19},[],{"title":1997},{"EN":1998},"Safety and Environmental Protection Division, Brookhaven National Laboratory, Upton, New York",[],{"title":2001,"openalex":2003},{"EN":2002},"P.G. Kale",{"VOID":2004},"A5070445445",{"url":19,"publisher":2006,"properties":2015},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2007,"slug":10,"properties":2008,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":2012,"manageAffiliations":2013,"indexDatabases":2014,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":2009,"title":2010,"eissn":2011},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":2016,"pages":2017,"volume":2019},{"VOID":1364},{"VOID":2018},"153-188",{"VOID":1104},658,{"total":2020,"publishYear":1107,"statisticByYear":2022},{"2012":2023,"2013":2024,"2014":2023,"2015":2025,"2016":2026,"2017":2027,"2018":2028,"2019":2029,"2020":2030,"2021":2031,"2022":2024,"2023":2032,"2024":2033},19,32,22,27,17,24,28,18,23,16,10,[],[2036,2039,2042,2045,2048,2051,2054,2057,2060,2063,2066,2069,2072,2075,2079,2082,2085,2088,2091,2094,2097,2100,2103,2106,2109,2112,2115,2118,2121,2124,2127,2130,2133,2136,2139,2142,2145,2149,2152,2155,2158,2161,2164,2167,2170,2173,2176,2179,2182,2186,2189,2192,2195,2198,2201,2204,2207,2210,2213,2216,2219,2222,2225,2228,2231,2234,2237,2241,2244,2247,2250],{"id":19,"text":2037,"url":19,"identifiers":2038},"Aaron CS, 1977, EMS effect on consumption behavior in Drosophila, Dros Inf Serv, 52, 166",{},{"id":19,"text":2040,"url":19,"identifiers":2041},"10.1016\u002F0027-5107(80)90085-8",{"doi":2040},{"id":19,"text":2043,"url":19,"identifiers":2044},"10.1038\u002F2151281a0",{"doi":2043},{"id":19,"text":2046,"url":19,"identifiers":2047},"Auerbach C, 1945, The problem of chromosome rearrangements in somatic cells of Drosophila melanogaster, Proc R Soc Edinburgh, 862, 120",{},{"id":19,"text":2049,"url":19,"identifiers":2050},"10.3109\u002F03602538008994025",{"doi":2049},{"id":19,"text":2052,"url":19,"identifiers":2053},"10.1093\u002Fgenetics\u002F90.3.531",{"doi":2052},{"id":19,"text":2055,"url":19,"identifiers":2056},"10.1007\u002FBF00268823",{"doi":2055},{"id":19,"text":2058,"url":19,"identifiers":2059},"Becker HJ, 1976, The Genetics and Biology of Drosophila, 1019",{},{"id":19,"text":2061,"url":19,"identifiers":2062},"10.1016\u002F0027-5107(77)90042-2",{"doi":2061},{"id":19,"text":2064,"url":19,"identifiers":2065},"10.1016\u002FS0027-5107(74)80050-3",{"doi":2064},{"id":19,"text":2067,"url":19,"identifiers":2068},"10.1016\u002F0012-1606(70)90160-0",{"doi":2067},{"id":19,"text":2070,"url":19,"identifiers":2071},"10.1038\u002F289353a0",{"doi":2070},{"id":19,"text":2073,"url":19,"identifiers":2074},"10.1016\u002F0027-5107(77)90141-5",{"doi":2073},{"id":19,"text":2076,"url":19,"identifiers":2077},"CandrianU LuthyJ GrafU SchlatterC(1984): Mutagenic activity of the pyrrolizidine alkaloids seneciphylline and senkirkine in Drosophila and their transfer into rat milk.Food and Chemical Toxicology(in press).",{"doi":2078},"10.1016\u002F0278-6915(84)90131-5",{"id":19,"text":2080,"url":19,"identifiers":2081},"10.1017\u002FS0016672300012039",{"doi":2080},{"id":19,"text":2083,"url":19,"identifiers":2084},"10.1101\u002FSQB.1978.042.01.101",{"doi":2083},{"id":19,"text":2086,"url":19,"identifiers":2087},"10.2307\u002F3001616",{"doi":2086},{"id":19,"text":2089,"url":19,"identifiers":2090},"10.1016\u002F0165-1218(80)90040-3",{"doi":2089},{"id":19,"text":2092,"url":19,"identifiers":2093},"10.1007\u002FBF02078996",{"doi":2092},{"id":19,"text":2095,"url":19,"identifiers":2096},"Ferris GF, 1950, Biology of Drosophila, 368",{},{"id":19,"text":2098,"url":19,"identifiers":2099},"FörsterRE(1982): In vitro Untersuchungen über den Metabolismus von Aflatoxin B1und Aldrin in Hodengewebe von genetisch verschiedenen Stämmen von Drosophila melanogaster. Dissertation ETH‐Zürich Nr. 7081 ADAG Administration und Druck AG Zurich pp.101.",{},{"id":19,"text":2101,"url":19,"identifiers":2102},"10.1016\u002F0012-1606(66)90017-0",{"doi":2101},{"id":19,"text":2104,"url":19,"identifiers":2105},"10.1007\u002FBF00272218",{"doi":2104},{"id":19,"text":2107,"url":19,"identifiers":2108},"10.1016\u002F0012-1606(71)90047-9",{"doi":2107},{"id":19,"text":2110,"url":19,"identifiers":2111},"10.1016\u002F0012-1606(71)90126-6",{"doi":2110},{"id":19,"text":2113,"url":19,"identifiers":2114},"10.1007\u002FBF02654485",{"doi":2113},{"id":19,"text":2116,"url":19,"identifiers":2117},"10.1016\u002F0012-1606(76)90052-X",{"doi":2116},{"id":19,"text":2119,"url":19,"identifiers":2120},"10.1016\u002F0165-7992(83)90095-7",{"doi":2119},{"id":19,"text":2122,"url":19,"identifiers":2123},"10.1016\u002F0009-2797(81)90127-7",{"doi":2122},{"id":19,"text":2125,"url":19,"identifiers":2126},"10.1016\u002F0009-2797(81)90126-5",{"doi":2125},{"id":19,"text":2128,"url":19,"identifiers":2129},"10.1007\u002FBF00848779",{"doi":2128},{"id":19,"text":2131,"url":19,"identifiers":2132},"10.1073\u002Fpnas.50.2.372",{"doi":2131},{"id":19,"text":2134,"url":19,"identifiers":2135},"HolzerCN(1981):Untersuchungen über Metabolismus und Mutagenitat von Nitrosaminen und Aflatoxin B1in Drosophila melanogaster. Dissertation ETH‐Zürich Nr. 6893 ADAG Adminstration und Druck AG Zurich pp.84.",{},{"id":19,"text":2137,"url":19,"identifiers":2138},"10.1111\u002Fj.1601-5223.1982.tb00712.x",{"doi":2137},{"id":19,"text":2140,"url":19,"identifiers":2141},"10.1016\u002F0165-1218(79)90078-8",{"doi":2140},{"id":19,"text":2143,"url":19,"identifiers":2144},"10.1002\u002Fem.2860040607",{"doi":2143},{"id":19,"text":2146,"url":19,"identifiers":2147},"Kennison JA, 1981, Spontaneous mitotic recombination and evidence for an X‐ray‐inducible system for the repair of DNA damage in Drosophila melanogaster, Genetics, 98, 91, 10.1093\u002Fgenetics\u002F98.1.91",{"doi":2148},"10.1093\u002Fgenetics\u002F98.1.91",{"id":19,"text":2150,"url":19,"identifiers":2151},"10.1016\u002F0165-1218(79)90007-7",{"doi":2150},{"id":19,"text":2153,"url":19,"identifiers":2154},"10.1002\u002Fem.2860040609",{"doi":2153},{"id":19,"text":2156,"url":19,"identifiers":2157},"Lee WR, 1976, The Genetics and Biology of Drosophila, 1299",{},{"id":19,"text":2159,"url":19,"identifiers":2160},"10.1016\u002F0165-1110(83)90025-8",{"doi":2159},{"id":19,"text":2162,"url":19,"identifiers":2163},"Lindgren BW, 1976, Statistical Theory, 614",{},{"id":19,"text":2165,"url":19,"identifiers":2166},"Lindsley DL, 1968, Genetic variations of Drosophila melanogaster, 627",{},{"id":19,"text":2168,"url":19,"identifiers":2169},"10.1007\u002FBF00333169",{"doi":2168},{"id":19,"text":2171,"url":19,"identifiers":2172},"10.1016\u002F0027-5107(74)90074-8",{"doi":2171},{"id":19,"text":2174,"url":19,"identifiers":2175},"Nöthiger R, 1970, Sucrose density separation: A method for collecting large numbers of Drosophila larvae, Dros Inf Serv, 45, 177",{},{"id":19,"text":2177,"url":19,"identifiers":2178},"10.1016\u002F0027-5107(82)90214-7",{"doi":2177},{"id":19,"text":2180,"url":19,"identifiers":2181},"Radman M, 1980, Molecular and Cellular Aspects of Carcinogen Screening Tests, 75",{},{"id":19,"text":2183,"url":19,"identifiers":2184},"Roscoe JT, 1971, Sample size restraints commonly imposed on the use of the chi‐square statistics, J Am Statist Assoc, 66, 755, 10.1080\u002F01621459.1971.10482341",{"doi":2185},"10.1080\u002F01621459.1971.10482341",{"id":19,"text":2187,"url":19,"identifiers":2188},"10.1016\u002F0165-1110(81)90011-7",{"doi":2187},{"id":19,"text":2190,"url":19,"identifiers":2191},"10.1007\u002F978-3-662-05749-0",{"doi":2190},{"id":19,"text":2193,"url":19,"identifiers":2194},"10.1016\u002F0027-5107(81)90022-1",{"doi":2193},{"id":19,"text":2196,"url":19,"identifiers":2197},"10.1016\u002F0027-5107(79)90144-1",{"doi":2196},{"id":19,"text":2199,"url":19,"identifiers":2200},"10.1016\u002F0027-5107(80)90037-8",{"doi":2199},{"id":19,"text":2202,"url":19,"identifiers":2203},"Simmon VF, 1979, In vitro assays for recombinogenic activity of chemical carcinogens and related compounds with Saccharomyces cerevisiae D3, J Natl Cancer Inst, 62, 901",{},{"id":19,"text":2205,"url":19,"identifiers":2206},"10.1016\u002F0012-1606(79)90284-7",{"doi":2205},{"id":19,"text":2208,"url":19,"identifiers":2209},"10.1146\u002Fannurev.bi.45.070176.003411",{"doi":2208},{"id":19,"text":2211,"url":19,"identifiers":2212},"10.1016\u002F0165-1161(83)90224-8",{"doi":2211},{"id":19,"text":2214,"url":19,"identifiers":2215},"10.1016\u002F0165-1110(78)90019-2",{"doi":2214},{"id":19,"text":2217,"url":19,"identifiers":2218},"Vogel E, 1977, Origins of Human Cancer, 1483",{},{"id":19,"text":2220,"url":19,"identifiers":2221},"VogelEW(1982):Dependence of mutagenesis in Drosophila males on metabolism and germ cell stage.",{},{"id":19,"text":2223,"url":19,"identifiers":2224},"Sugimura T, Environmental Mutagens and Carcinogens, 183",{},{"id":19,"text":2226,"url":19,"identifiers":2227},"10.1016\u002F0027-5107(75)90059-7",{"doi":2226},{"id":19,"text":2229,"url":19,"identifiers":2230},"Vogel E, 1980, The Predictive Value of Short‐Term Screening Tests in Carcinogenicity, 125",{},{"id":19,"text":2232,"url":19,"identifiers":2233},"10.1007\u002F978-1-4613-3409-5_9",{"doi":2232},{"id":19,"text":2235,"url":19,"identifiers":2236},"10.1016\u002F0027-5107(83)90078-7",{"doi":2235},{"id":19,"text":2238,"url":19,"identifiers":2239},"Whittinghill M, 1961, Clustered crossovers from male Drosophila raised on formaldehyde media, Genetics, 46, 459, 10.1093\u002Fgenetics\u002F46.5.459",{"doi":2240},"10.1093\u002Fgenetics\u002F46.5.459",{"id":19,"text":2242,"url":19,"identifiers":2243},"Wilson L, 1975, Microtubules and Microtubule Inhibitors, 103",{},{"id":19,"text":2245,"url":19,"identifiers":2246},"WürglerFE GrafU FreiH JuonH(1983a):Detection of point mutations chromosome aberrations and somatic recombination in Drosophila melanogaster. In “Critical Evaluation of Mutagenicity Tests.” Symposium of the Institute for Drugs Federal Health Office Berlin February 22–25 1982 (in press).",{},{"id":19,"text":2248,"url":19,"identifiers":2249},"10.1016\u002F0165-7992(83)90014-3",{"doi":2248},{"id":19,"text":2251,"url":19,"identifiers":2252},"10.1016\u002F0027-5107(75)90232-8",{"doi":2251},{"id":2254,"createTime":2255,"updateTime":2255,"relativeEntities":2256,"slug":2257,"properties":2258,"entityType":47,"verifyStatus":48,"verifyTime":2255,"verifyNote":49,"languages":2271,"translateLanguages":19,"viewCount":20,"primaryUrl":2272,"fullTextUrl":19,"authors":2273,"publicationType":143,"publisherRelationship":2329,"citationCount":2344,"citationInfo":2345,"publishDate":1747,"publishYear":1745,"citationAnalyzeStatus":18,"lastCitationAnalyze":19,"indexDatabases":2347,"openAccess":19,"references":2348,"isForceReanalyzing":262},"27a7ebcd-429f-4da5-b8a0-883e8b8af274","2024-10-05T22:30:40.341+00:00",[],"Sister-chromatid-exchanges-in-chines-hamster-cells-treated-with-seventeen-organophosphorus-compounds-in-the-presence-of-a-metabolic-activation-system",{"openalex":2259,"mag":2261,"abstract":2263,"title":2265,"pm":2267,"doi":2269},{"VOID":2260},"W2003861903",{"VOID":2262},"2003861903",{"EN":2264},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The mutagenicity of several organophosphorus pesticides (OPP) has been demonstrated by Wild [1975] in microorganisms. However, the results as reported in the literature of cytogenic, mutagenic, and carcinogenic tests using mammalian cells or experimental animals were scanty and inconclusive [Huang, 1973; Wild, 1975]. This may be partly due to the high toxicity and rapid degradation of these compounds by mammalian cells both in vitro and in vivo [Wild, 1975]. Since sister chromatid exchange (SCE) has proved to be a highly sensitive indicator of genetic damage [Latt, 1975] and for certain chemicals there was a good correlation between the induction of SCE and point mutations in mammalian cells [Carrano et al, 1978; Sirianni and Huang, 1980], we have studied and reported the effect of a total of 17 OPP on induction of sister chromatid exchange and cell cycle delay in an in vitro system using V79 cells without metabolic activation [Chen et al, 1981, 1982]. Among the 17 OPP tested, 8 were able to induce increased SCE frequencies and the other 9 caused no increase in SCE as compared to the control values. The OPP that proved to be positive SCE inducers were methyl‐parathion, demeton, trichlorfon, dimethoate, malathion, methidathion, oxydemeton methyl, and fenthion. The other nine that caused no SCE increase were diazinion, disyston, amaze, azinphosmethyl, bolstar, DEF, fensulfothion, monitor, and nemacur. In addition, cell cycle delay in various degrees was observed after treatment of V79 cells with all the OPP except for fensulfothion and oxydemeton methyl. However, for all experiments there was no clear correlation between the degree of cell cycle delay and induction of SCE.\u003C\u002Fjats:p>",{"EN":2266},"Sister chromatid exchanges in chines hamster cells treated with seventeen organophosphorus compounds in the presence of a metabolic activation system",{"VOID":2268},"7140680",{"VOID":2270},"10.1002\u002Fem.2860040513",[51],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860040513",[2274,2291,2314],{"id":2275,"sortIndex":20,"researcher":19,"roles":2276,"affiliations":2277,"properties":2286,"displayName":2288,"givenName":19,"familyName":19},"c4a18e22-6f3c-4fb1-83b8-ec30901b1e9d",[],[2278],{"id":2279,"sortIndex":20,"affiliation":2280,"properties":19},"1e42369f-1ad6-4c0e-af0b-22dd0270baf2",{"id":2279,"createTime":19,"updateTime":19,"relativeEntities":2281,"slug":19,"properties":2282,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":2285,"statistic":19},[],{"title":2283},{"EN":2284},"Department of Experimental Biology, Roswell Park Memorial Institute, Buffalo, New York",[],{"title":2287,"openalex":2289},{"EN":2288},"H. H. Chen",{"VOID":2290},"A5087044245",{"id":2292,"sortIndex":73,"researcher":19,"roles":2293,"affiliations":2294,"properties":2309,"displayName":2311,"givenName":19,"familyName":19},"2ab19f3f-907f-4d90-a2f4-a6b3e68ec221",[],[2295,2301],{"id":2279,"sortIndex":20,"affiliation":2296,"properties":19},{"id":2279,"createTime":19,"updateTime":19,"relativeEntities":2297,"slug":19,"properties":2298,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":2300,"statistic":19},[],{"title":2299},{"EN":2284},[],{"id":2302,"sortIndex":73,"affiliation":2303,"properties":19},"99b3d1af-2e16-42a8-be78-7823b2d2da21",{"id":2302,"createTime":19,"updateTime":19,"relativeEntities":2304,"slug":19,"properties":2305,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":2308,"statistic":19},[],{"title":2306},{"EN":2307},"S.R. Sirianni is a medical student at the State University of New York at Buffalo, Buffalo, NY 14214.",[],{"title":2310,"openalex":2312},{"EN":2311},"S.R. Sirianni",{"VOID":2313},"A5043542474",{"id":2315,"sortIndex":89,"researcher":19,"roles":2316,"affiliations":2317,"properties":2324,"displayName":2326,"givenName":19,"familyName":19},"dc429f22-8287-45a6-bb02-ed6820d9833e",[],[2318],{"id":2279,"sortIndex":20,"affiliation":2319,"properties":19},{"id":2279,"createTime":19,"updateTime":19,"relativeEntities":2320,"slug":19,"properties":2321,"entityType":19,"verifyStatus":19,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":19,"url":19,"parentIds":2323,"statistic":19},[],{"title":2322},{"EN":2284},[],{"title":2325,"openalex":2327},{"EN":2326},"C. C. Huang",{"VOID":2328},"A5103460295",{"url":19,"publisher":2330,"properties":2339},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2331,"slug":10,"properties":2332,"entityType":17,"verifyStatus":18,"verifyTime":19,"verifyNote":19,"languages":19,"translateLanguages":19,"viewCount":20,"subjectFields":2336,"manageAffiliations":2337,"indexDatabases":2338,"url":19,"thumbnailPath":19,"statistic":19,"gsStatistic":19,"type":19,"analyzePriority":19},[],{"issn":2333,"title":2334,"eissn":2335},{"VOID":13},{"EN":10},{"VOID":16},[],[],[],{"issue":2340,"pages":2341,"volume":2343},{"VOID":160},{"VOID":2342},"621-624",{"VOID":1575},33,{"total":2344,"publishYear":1745,"statisticByYear":2346},{"2017":73},[],[2349,2351,2354,2357,2360,2363,2366,2368,2371],{"id":19,"text":1382,"url":19,"identifiers":2350},{"doi":1382},{"id":19,"text":2352,"url":19,"identifiers":2353},"10.1016\u002F0165-1218(81)90042-2",{"doi":2352},{"id":19,"text":2355,"url":19,"identifiers":2356},"10.1016\u002F0165-7992(82)90059-8",{"doi":2355},{"id":19,"text":2358,"url":19,"identifiers":2359},"10.3181\u002F00379727-142-36952",{"doi":2358},{"id":19,"text":2361,"url":19,"identifiers":2362},"Huang CC, 1980, An in vitro metabolic activation assay using liver microsomes in diffusion chambers: Induction of sister chromatid exchanges and chromosome aberrations by cyclophosphamide or ifosfamide in cultured human and Chinese hamster cells, Car‐cinogenesis (New York), 1, 37",{},{"id":19,"text":2364,"url":19,"identifiers":2365},"10.1073\u002Fpnas.71.8.3162",{"doi":2364},{"id":19,"text":762,"url":19,"identifiers":2367},{"doi":762},{"id":19,"text":2369,"url":19,"identifiers":2370},"10.1093\u002Fcarcin\u002F1.4.353",{"doi":2369},{"id":19,"text":2372,"url":19,"identifiers":2373},"10.1016\u002F0165-1110(75)90003-2",{"doi":2372}]