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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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Induced mutations are detected as single mosaic spots on the wing blade of surviving adults that show either the multiple wing hairs or flare phenotype. Induced recombination leads to mwh and fir twin spots and also to a certain extent, to mwh single spots. Recording of the frequency and the size of the different spots allows for a quantitative determination of the mutagenic and recombinogenic effects. This and earlier studies with a small set of well‐known mutagens indicate that the test detects monofunctional and polyfunctional alkylating agents (ethyl methanesulfonate, diepoxybutane, mitomycin C, Trenimon), mutagens forming large adducts (aflatoxin B\u003Cjats:sub>1\u003C\u002Fjats:sub>), DNA breaking agents (bleomycin), intercalating agents (5‐aminoacridine, ICR‐170), spindle poisons (vinblastine), and antimetabolites (methotrexate). 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Adv Enzymol 60‐1‐34.",{"doi":2401},"10.1002\u002F9780470123065.ch1",{"id":28,"text":2403,"url":28,"identifiers":2404},"10.1093\u002Fnar\u002F14.16.6621",{"doi":2403},{"id":28,"text":2406,"url":28,"identifiers":2407},"10.1111\u002Fj.1751-1097.1987.tb07879.x",{"doi":2406},{"id":28,"text":2409,"url":28,"identifiers":2410},"10.1073\u002Fpnas.75.4.1924",{"doi":2409},{"id":28,"text":2412,"url":28,"identifiers":2413},"10.1128\u002Fjb.126.3.1082-1088.1976",{"doi":2412},{"id":28,"text":2415,"url":28,"identifiers":2416},"10.1016\u002F0005-2787(73)90049-X",{"doi":2415},{"id":28,"text":2418,"url":28,"identifiers":2419},"10.1073\u002Fpnas.84.22.8016",{"doi":2418},{"id":28,"text":2421,"url":28,"identifiers":2422},"Winkelman JW, 1986, Anaerobically induced genes of Escherichia coli, J Bacteriol, 167, 362, 10.1128\u002Fjb.167.1.362-367.1986",{"doi":2423},"10.1128\u002Fjb.167.1.362-367.1986",{"id":28,"text":2425,"url":28,"identifiers":2426},"10.1016\u002F0165-7992(84)90087-3",{"doi":2425},{"id":28,"text":2428,"url":28,"identifiers":2429},"10.1016\u002F0005-2787(78)90225-3",{"doi":2428},{"id":28,"text":2431,"url":28,"identifiers":2432},"10.1016\u002F0167-4838(85)90264-X",{"doi":2431},{"id":28,"text":2434,"url":28,"identifiers":2435},"10.1073\u002Fpnas.72.2.688",{"doi":2434},{"id":2437,"createTime":2438,"updateTime":2438,"relativeEntities":2439,"slug":2440,"properties":2441,"entityType":905,"verifyStatus":26,"verifyTime":2438,"verifyNote":906,"languages":2454,"translateLanguages":28,"viewCount":32,"primaryUrl":2455,"fullTextUrl":28,"authors":2456,"publicationType":1035,"publisherRelationship":2523,"citationCount":359,"citationInfo":2540,"publishDate":2543,"publishYear":2541,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":2544,"openAccess":28,"references":2545,"isForceReanalyzing":1277},"7ca9044f-12fd-4d1e-a468-28c2fa4752aa","2024-12-26T05:26:41.290+00:00",[],"Comparative-cytogenetic-analysis-of-bone-marrow-damage-induced-in-male-B6C3F1-mice-by-multiple-exposures-to-gaseous-1-3-butadiene",{"openalex":2442,"mag":2444,"abstract":2446,"title":2448,"pm":2450,"doi":2452},{"VOID":2443},"W1994752319",{"VOID":2445},"1994752319",{"EN":2447},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Groups of male B6C3F1 mice (N = 12) were exposed to ambient air or to gaseous 1,3‐butadiene (BD) at 6.25, 62.5, and 625 ppm for 10 exposure days (6 hr + T\u003Cjats:sub>90\u003C\u002Fjats:sub>\u002Fday). Exposure to BD induced in bone marrow: 1) a significant increase in the frequency of chromosomal aberrations (CA); 2) a significant elevation in the frequency of sister chromatid exchanges (SCE); 3) a significant lengthening of the average generation time (AGT); 4) a significant depression in the mitotic index (MI); and, as measured in the peripheral blood, 5) a significant increase in the proportion of circulating polychromatic erythrocytes (%PCE), and 6) a significant increase in the level of micronucleated PCE (MN‐PCE) and micronucleated normochromatic erythrocytes (MN‐NCE). The most sensitive indicator of genotoxic damage was the frequency of SCE (significant at 6.25 ppm), followed by MN‐PCE levels (significant at 62.5 ppm), and then by CA and MN‐NCE frequencies (significant at 625 ppm). The most sensitive measure of cytotoxic damage was AGT (significant at 62.5 ppm), followed by %PCE (significant at 625 ppm), and then by MI (significant by trend test only). Because each cytogenetic endpoint was evaluated in every animal, a correlation analysis was conducted to evaluate the degree of concordance among the various indicators of genotoxic and cytotoxic damage. The extent of concordance ranged from a very good correlation between the induction of MN‐PCE and the induction of SCE (correlation coefficient r = 0.9562) to the lack of a significant correlation between the depression in the MI and any other endpoint (r < 0.37).\u003C\u002Fjats:p>",{"EN":2449},"Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3‐butadiene",{"VOID":2451},"3569168",{"VOID":2453},"10.1002\u002Fem.2860090303",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860090303",[2457,2474,2491,2506],{"id":2458,"sortIndex":32,"researcher":28,"roles":2459,"affiliations":2460,"properties":2469,"displayName":2471,"givenName":28,"familyName":28},"849284de-01aa-4cb7-bc0f-0d526da770c0",[],[2461],{"id":2462,"sortIndex":32,"affiliation":2463,"properties":28},"74985163-8717-400e-bea0-ade68dedc37e",{"id":2462,"createTime":28,"updateTime":28,"relativeEntities":2464,"slug":28,"properties":2465,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2468,"statistic":28},[],{"title":2466},{"VI":2467},"Medical Department, Brookhaven National Laboratory, Upton, NY 11973",[],{"title":2470,"openalex":2472},{"EN":2471},"Raymond R. 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Luke",{"VOID":2505},"A5083080917",{"id":2507,"sortIndex":42,"researcher":28,"roles":2508,"affiliations":2509,"properties":2518,"displayName":2520,"givenName":28,"familyName":28},"9f4c4a7a-545b-41af-b82d-aa5bcecdcb6c",[],[2510],{"id":2511,"sortIndex":32,"affiliation":2512,"properties":28},"a72a27b9-585e-47a3-ba6c-69867047dc5c",{"id":2511,"createTime":28,"updateTime":28,"relativeEntities":2513,"slug":28,"properties":2514,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2517,"statistic":28},[],{"title":2515},{"EN":2516},"National Toxicology Program , NIEHS , Research Triangle Park, North Carolina",[],{"title":2519,"openalex":2521},{"EN":2520},"Michael D. Shelby",{"VOID":2522},"A5027953355",{"url":28,"publisher":2524,"properties":2533},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2525,"slug":872,"properties":2526,"entityType":25,"verifyStatus":879,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2530,"manageAffiliations":2531,"indexDatabases":2532,"url":28,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"issn":2527,"title":2528,"eissn":2529},{"VOID":875},{"EN":872},{"VOID":878},[],[],[],{"issue":2534,"pages":2536,"volume":2538},{"VOID":2535},"3",{"VOID":2537},"235-250",{"VOID":2539},"9",{"total":359,"publishYear":2541,"statisticByYear":2542},1987,{"2012":123,"2013":123,"2015":40,"2016":123,"2017":40,"2018":40,"2019":40,"2021":40,"2023":40},"1987-01-01",[],[2546,2549,2552,2555,2558,2561,2564,2567,2570,2573,2576,2579,2582,2585,2588,2591,2594,2597,2600,2603,2606,2609,2612,2615,2618,2621,2624,2627,2630,2633,2636,2639,2643,2646,2649,2652],{"id":28,"text":2547,"url":28,"identifiers":2548},"10.1016\u002F0024-3205(69)90020-4",{"doi":2547},{"id":28,"text":2550,"url":28,"identifiers":2551},"10.1016\u002F0041-008X(86)90268-1",{"doi":2550},{"id":28,"text":2553,"url":28,"identifiers":2554},"Choy W‐N, 1986, Genotoxicity of 1,3‐butadiene. Induction of bone marrow micronuclei in B6C3F1 mice and Sprague‐Dawley rats in vivo, Environ Mutagen, 8, 18",{},{"id":28,"text":2556,"url":28,"identifiers":2557},"10.1016\u002F0027-5107(83)90124-0",{"doi":2556},{"id":28,"text":2559,"url":28,"identifiers":2560},"Cunningham MJ, 1986, Genotoxicity of 1,3‐butadiene. Induction of sister chromatid exchanges in B6C3F1 mice and Sprague‐Dawley rats, Environ Mutagen, 8, 20",{},{"id":28,"text":2562,"url":28,"identifiers":2563},"10.1016\u002F0378-4274(80)90179-4",{"doi":2562},{"id":28,"text":2565,"url":28,"identifiers":2566},"10.1007\u002FBF00329173",{"doi":2565},{"id":28,"text":2568,"url":28,"identifiers":2569},"10.1016\u002F0027-5107(84)90014-9",{"doi":2568},{"id":28,"text":2571,"url":28,"identifiers":2572},"Hazleton Laboratories Europe(1981):1 3‐Butadiene. Inhalation Teratogenicity Study in the Rat. Final Report and Addendum No. 2788‐522\u002F3. Hazleton Labs Harrowgate HG3 IPY UK.",{},{"id":28,"text":2574,"url":28,"identifiers":2575},"10.1016\u002F0165-1110(83)90047-7",{"doi":2574},{"id":28,"text":2577,"url":28,"identifiers":2578},"10.1126\u002Fscience.3966163",{"doi":2577},{"id":28,"text":2580,"url":28,"identifiers":2581},"10.1016\u002F0041-008X(86)90326-1",{"doi":2580},{"id":28,"text":2583,"url":28,"identifiers":2584},"10.1016\u002F0041-008X(86)90352-2",{"doi":2583},{"id":28,"text":2586,"url":28,"identifiers":2587},"Ivett JL, 1982, Average generation time: A new method for analyzing cellular proliferation kinetics based on bromodeoxyuridine‐dependent chromosomal differential staining patterns, Environ Mutagen, 4, 358",{},{"id":28,"text":2589,"url":28,"identifiers":2590},"10.1080\u002F09553008214550171",{"doi":2589},{"id":28,"text":2592,"url":28,"identifiers":2593},"10.1038\u002F251070a0",{"doi":2592},{"id":28,"text":2595,"url":28,"identifiers":2596},"Kirk‐Othmen Encyclopedia of Chemical Technology, 1979, Butadiene, 313",{},{"id":28,"text":2598,"url":28,"identifiers":2599},"10.1016\u002F0378-4274(86)90095-0",{"doi":2598},{"id":28,"text":2601,"url":28,"identifiers":2602},"10.1016\u002F0165-1110(81)90003-8",{"doi":2601},{"id":28,"text":2604,"url":28,"identifiers":2605},"10.1016\u002F0014-4800(86)90032-8",{"doi":2604},{"id":28,"text":2607,"url":28,"identifiers":2608},"Luke CA, 1985, Duration and regimen induced micronuclei in the peripheral blood of mice exposed chronically to benzene, Environ Mutagen, 7, 29",{},{"id":28,"text":2610,"url":28,"identifiers":2611},"10.1002\u002Fem.2860020408",{"doi":2610},{"id":28,"text":2613,"url":28,"identifiers":2614},"Margolin BH, 1986, Evaluation of Short‐Term Tests for Carcinogens: Report of the International Programme on Chemical Safety's Collaborative Study on In Vivo Assays",{},{"id":28,"text":2616,"url":28,"identifiers":2617},"10.1002\u002Fem.2860080203",{"doi":2616},{"id":28,"text":2619,"url":28,"identifiers":2620},"10.1016\u002F0165-7992(83)90042-8",{"doi":2619},{"id":28,"text":2622,"url":28,"identifiers":2623},"10.1016\u002F0027-5107(82)90241-X",{"doi":2622},{"id":28,"text":2625,"url":28,"identifiers":2626},"10.1007\u002F978-3-642-67729-8_14",{"doi":2625},{"id":28,"text":2628,"url":28,"identifiers":2629},"10.1016\u002F0165-1110(81)90030-0",{"doi":2628},{"id":28,"text":2631,"url":28,"identifiers":2632},"10.1002\u002Fem.2860070615",{"doi":2631},{"id":28,"text":2634,"url":28,"identifiers":2635},"10.1016\u002F0047-6374(81)90051-8",{"doi":2634},{"id":28,"text":2637,"url":28,"identifiers":2638},"10.1002\u002Fem.2860080312",{"doi":2637},{"id":28,"text":2640,"url":28,"identifiers":2641},"ThurmondLM LauerLD HouseRV StillmanWS IronsRD SteinhagenWH DeanJW(1986):Effect of short‐term inhalation exposure to 1 3‐butadiene on murine immune functions. Toxicol Applied Pharmacol (in press).",{"doi":2642},"10.1016\u002F0041-008X(86)90047-5",{"id":28,"text":2644,"url":28,"identifiers":2645},"10.1016\u002F0165-1218(78)90022-8",{"doi":2644},{"id":28,"text":2647,"url":28,"identifiers":2648},"Tice RR, 1985, Toxicology of the Blood and Bone Marrow, 119",{},{"id":28,"text":2650,"url":28,"identifiers":2651},"TiceRR LukeCA ShelbyMD(1986):Methyl isocyanate: An evaluation of in vivo cytogenetic activity. Environ Mutagen (in press).",{},{"id":28,"text":2653,"url":28,"identifiers":2654},"10.1016\u002F0014-4827(76)90037-9",{"doi":2653},{"id":2656,"createTime":2657,"updateTime":2657,"relativeEntities":2658,"slug":2659,"properties":2660,"entityType":905,"verifyStatus":26,"verifyTime":2657,"verifyNote":906,"languages":2673,"translateLanguages":28,"viewCount":32,"primaryUrl":2674,"fullTextUrl":28,"authors":2675,"publicationType":1035,"publisherRelationship":2761,"citationCount":2777,"citationInfo":2778,"publishDate":2781,"publishYear":2779,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":2782,"openAccess":28,"references":2783,"isForceReanalyzing":1277},"414eb0be-6508-4936-9628-a134e2467ca8","2024-10-07T07:42:45.235+00:00",[],"Ethylene-oxide-Evidence-of-human-chromosomal-effects",{"openalex":2661,"mag":2663,"abstract":2665,"title":2667,"pm":2669,"doi":2671},{"VOID":2662},"W2144912555",{"VOID":2664},"2144912555",{"EN":2666},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were employed. All persons whose work activities involved some aspect of the sterilization process were considered exposed to the gas. Within this group of symptomatic and asymptomatic individuals, chronic and incidental exposure was documented by clinical history. Sister chromatid exchanges were studied in lymphocytes cultured from exposed individuals as well as comparable controls. Four chronically exposed persons who reported upper respiratory and neurologic symptoms were studied in some detail. This group showed significantly increased sister chromatid exchange at three weeks and again at eight weeks after the last known exposure. Another group of eight persons with fewer complaints studied as late as the ninth week showed significantly increased exchanges. Incidental exposure may also increase sister chromatid exchange. The measured maximum concentration of ethylene oxide in the sterilizer room was 36 ppm (within standards set by the Occupational Safety and Health Administration).\u003C\u002Fjats:p>",{"EN":2668},"Ethylene oxide: Evidence of human chromosomal effects",{"VOID":2670},"553808",{"VOID":2672},"10.1002\u002Fem.2860010410",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860010410",[2676,2693,2710,2729,2746],{"id":2677,"sortIndex":32,"researcher":28,"roles":2678,"affiliations":2679,"properties":2688,"displayName":2690,"givenName":28,"familyName":28},"378794d4-60eb-464f-b7b1-fd1cd0bfea6a",[],[2680],{"id":2681,"sortIndex":32,"affiliation":2682,"properties":28},"c9b78b53-02e2-45c6-aea6-0ece644d2419",{"id":2681,"createTime":28,"updateTime":28,"relativeEntities":2683,"slug":28,"properties":2684,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2687,"statistic":28},[],{"title":2685},{"EN":2686},"Department of Laboratory Medicine, University of Minnesota, Box 198, Mayo, Minneapolis, MN 55455",[],{"title":2689,"openalex":2691},{"EN":2690},"Vincent F. 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Gray",{"VOID":2760},"A5036197254",{"url":28,"publisher":2762,"properties":2771},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2763,"slug":872,"properties":2764,"entityType":25,"verifyStatus":879,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2768,"manageAffiliations":2769,"indexDatabases":2770,"url":28,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"issn":2765,"title":2766,"eissn":2767},{"VOID":875},{"EN":872},{"VOID":878},[],[],[],{"issue":2772,"pages":2773,"volume":2775},{"VOID":1328},{"VOID":2774},"375-382",{"VOID":2776},"1",103,{"total":2777,"publishYear":2779,"statisticByYear":2780},1979,{"2012":42,"2016":40,"2019":40},"1979-01-01",[],[2784,2787,2790,2793,2797,2800,2803,2806,2809,2812,2815,2818,2821,2824,2827,2830,2834,2837,2840,2843,2846,2850,2852,2855,2858,2861,2864,2867,2870,2873,2876],{"id":28,"text":2785,"url":28,"identifiers":2786},"Glaser ZR, 1977, Use of Ethylene Oxide as a Sterilant in Medical Facilities",{},{"id":28,"text":2788,"url":28,"identifiers":2789},"Gross JA, 1978, Ethylene oxide neuropathy, Neurology, 28, 355",{},{"id":28,"text":2791,"url":28,"identifiers":2792},"EhrenbergL HallstronT: Haematologic studies on persons occupationally exposed to ethylene oxide. In: International Agency Report; SM 92\u002F26 1967 pp327–334.",{},{"id":28,"text":2794,"url":28,"identifiers":2795},"Frankel‐Conrat H, 1944, The actions of 1,2‐epoxides on proteins, J Biol Chem, 154, 227, 10.1016\u002FS0021-9258(18)71961-3",{"doi":2796},"10.1016\u002FS0021-9258(18)71961-3",{"id":28,"text":2798,"url":28,"identifiers":2799},"Frankel‐Conrat H, 1961, Chemical modification of viral ribonucleic acid. Part 1. Alkylating agents, Biochem Biophys Acta, 49, 165",{},{"id":28,"text":2801,"url":28,"identifiers":2802},"10.1016\u002F0027-5107(74)90123-7",{"doi":2801},{"id":28,"text":2804,"url":28,"identifiers":2805},"10.1073\u002Fpnas.70.12.3395",{"doi":2804},{"id":28,"text":2807,"url":28,"identifiers":2808},"10.1038\u002F251156a0",{"doi":2807},{"id":28,"text":2810,"url":28,"identifiers":2811},"10.1038\u002F258121a0",{"doi":2810},{"id":28,"text":2813,"url":28,"identifiers":2814},"10.1016\u002F0014-4827(73)90356-X",{"doi":2813},{"id":28,"text":2816,"url":28,"identifiers":2817},"10.1007\u002FBF00390438",{"doi":2816},{"id":28,"text":2819,"url":28,"identifiers":2820},"10.1016\u002F0027-5107(78)90274-9",{"doi":2819},{"id":28,"text":2822,"url":28,"identifiers":2823},"National Institute for Occupational Safety and Health, 1974, NIOSH Manual of Analytical Methods",{},{"id":28,"text":2825,"url":28,"identifiers":2826},"Department of Health, Education, and Welfare, 1977, Occupational Diseases: A Guide to Their Recognition, 203",{},{"id":28,"text":2828,"url":28,"identifiers":2829},"Fujii K, 1969, Carcinogenicity of food additives, pesticides, and drugs, Toxicol Appl Pharmacol, 14, 613",{},{"id":28,"text":2831,"url":28,"identifiers":2832},"Shiraishi Y, 1972, Chromosomal abnormalities in cultured leucocyte cells from Itai Itai disease patients, Proc Jpn Acad, 48, 248, 10.2183\u002Fpjab1945.48.248",{"doi":2833},"10.2183\u002Fpjab1945.48.248",{"id":28,"text":2835,"url":28,"identifiers":2836},"10.1007\u002F978-1-4757-4429-3_3",{"doi":2835},{"id":28,"text":2838,"url":28,"identifiers":2839},"Evans HJ, 1975, Symposium of the Society for the Study of Human Biology, 63",{},{"id":28,"text":2841,"url":28,"identifiers":2842},"Embree JW, 1973, Mutagenicity of ethylene oxide, Toxicol Appl Pharmacol, 33, 172",{},{"id":28,"text":2844,"url":28,"identifiers":2845},"10.1016\u002F0027-5107(77)90206-8",{"doi":2844},{"id":28,"text":2847,"url":28,"identifiers":2848},"Taylor JH, 1958, Sister chromatid exchange in tritium‐labelled chromosomes, Genetics, 43, 515, 10.1093\u002Fgenetics\u002F43.3.515",{"doi":2849},"10.1093\u002Fgenetics\u002F43.3.515",{"id":28,"text":2810,"url":28,"identifiers":2851},{"doi":2810},{"id":28,"text":2853,"url":28,"identifiers":2854},"10.1038\u002F271551a0",{"doi":2853},{"id":28,"text":2856,"url":28,"identifiers":2857},"10.1016\u002F0027-5107(78)90064-7",{"doi":2856},{"id":28,"text":2859,"url":28,"identifiers":2860},"10.1016\u002FS0027-5107(77)80032-8",{"doi":2859},{"id":28,"text":2862,"url":28,"identifiers":2863},"10.1159\u002F000130495",{"doi":2862},{"id":28,"text":2865,"url":28,"identifiers":2866},"10.1016\u002F0027-5107(78)90275-0",{"doi":2865},{"id":28,"text":2868,"url":28,"identifiers":2869},"Clinc MJ, 1975, The White Cell, 247",{},{"id":28,"text":2871,"url":28,"identifiers":2872},"10.1016\u002F0014-4827(78)90107-6",{"doi":2871},{"id":28,"text":2874,"url":28,"identifiers":2875},"10.1016\u002F0165-1218(79)90008-9",{"doi":2874},{"id":28,"text":2877,"url":28,"identifiers":2878},"LevinsonC: “Urgent Alert to Blood Cancer Hazard From Ethylene Oxide.” ICEF circular letter No. 97\u002F78. Geneva: International Federation of Chemical Energy and General Worker's Unions 1978.",{},{"id":2880,"createTime":2881,"updateTime":2881,"relativeEntities":2882,"slug":2883,"properties":2884,"entityType":905,"verifyStatus":26,"verifyTime":2897,"verifyNote":906,"languages":2898,"translateLanguages":28,"viewCount":32,"primaryUrl":2899,"fullTextUrl":28,"authors":2900,"publicationType":1035,"publisherRelationship":2965,"citationCount":2980,"citationInfo":2981,"publishDate":2984,"publishYear":2982,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":2985,"openAccess":28,"references":2986,"isForceReanalyzing":1277},"eca82655-379b-4d51-98d4-dfd002bf8b4c","2024-10-07T07:42:50.289+00:00",[],"Variation-in-the-baseline-sister-chromatid-exchange-frequency-in-human-lymphocytes",{"openalex":2885,"mag":2887,"abstract":2889,"title":2891,"pm":2893,"doi":2895},{"VOID":2886},"W2016202499",{"VOID":2888},"2016202499",{"EN":2890},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The utility of the sister chromatid exchange (SCE) assay for human population studies is potentially limited by the variability associated with individual baseline SCE frequencies. This investigation identifies and quantifies the major sources of preparative and biological variation associated with the determination of baseline SCE frequencies in cultured human lymphocytes. Much of the variation in lymphocyte SCE frequencies is attributable to the amount of bromodeoxyuridine (BrdUrd) available per lymphocyte; the pooled coefficient of variation (CV) over the dose range of 10 to 160 μM is about 18%. Other variations in the baseline frequency result from culture‐to‐culture and slide‐to‐slide differences. The pooled coefficient of variation among donors is about 10%. The effect of cell‐to‐cell differences in baseline SCE frequency among donors can be minimized by increasing the number of cells scored per donor. When 20 cells are analyzed per individual the pooled cell‐to‐cell variation is 9% but when 40 or 80 cells are analyzed it is reduced to 6 and 4% respectively. For a single individual the cell‐to‐cell coefficient of variation at 100 μM BrdUrd is 40.8%. Under our experimental conditions, a 30% increase in SCE frequency between two cohort populations can be detected with a 95% probability at a 5% level of significance when 11 individuals per cohort are studied. For a longitudinal or in vitro dose response study of a single individual, a 50% increase in SCE frequency can be detected with a 95% probability at a 5% level of significance when 25 cells per sample are analyzed. These results indicate the feasibility of applying the SCE bioassay to humans as a measure of environmental stress.\u003C\u002Fjats:p>",{"EN":2892},"Variation in the baseline sister chromatid exchange frequency in human lymphocytes",{"VOID":2894},"7318781",{"VOID":2896},"10.1002\u002Fem.2860020303","2024-10-07T07:42:50.288+00:00",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860020303",[2901,2918,2933,2948],{"id":2902,"sortIndex":32,"researcher":28,"roles":2903,"affiliations":2904,"properties":2913,"displayName":2915,"givenName":28,"familyName":28},"c878d84a-30da-4e27-ba6e-e090417550e2",[],[2905],{"id":2906,"sortIndex":32,"affiliation":2907,"properties":28},"0aaabe56-3754-4bc7-83ca-526fe5ee6f12",{"id":2906,"createTime":28,"updateTime":28,"relativeEntities":2908,"slug":28,"properties":2909,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2912,"statistic":28},[],{"title":2910},{"EN":2911},"Lawrence Livermore Laboratory, Biomedical Sciences Division, University of California, Livermore",[],{"title":2914,"openalex":2916},{"EN":2915},"A.V. Carrano",{"VOID":2917},"A5031903020",{"id":2919,"sortIndex":40,"researcher":28,"roles":2920,"affiliations":2921,"properties":2928,"displayName":2930,"givenName":28,"familyName":28},"fd9af263-40d1-4b34-a11b-7d24e3e6ea04",[],[2922],{"id":2906,"sortIndex":32,"affiliation":2923,"properties":28},{"id":2906,"createTime":28,"updateTime":28,"relativeEntities":2924,"slug":28,"properties":2925,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2927,"statistic":28},[],{"title":2926},{"EN":2911},[],{"title":2929,"openalex":2931},{"EN":2930},"J.L. Minkler",{"VOID":2932},"A5029872592",{"id":2934,"sortIndex":123,"researcher":28,"roles":2935,"affiliations":2936,"properties":2943,"displayName":2945,"givenName":28,"familyName":28},"c8315f5e-60b3-40d0-a56b-104f6e3c14a0",[],[2937],{"id":2906,"sortIndex":32,"affiliation":2938,"properties":28},{"id":2906,"createTime":28,"updateTime":28,"relativeEntities":2939,"slug":28,"properties":2940,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2942,"statistic":28},[],{"title":2941},{"EN":2911},[],{"title":2944,"openalex":2946},{"EN":2945},"Daniel G. Stetka",{"VOID":2947},"A5078118661",{"id":2949,"sortIndex":42,"researcher":28,"roles":2950,"affiliations":2951,"properties":2958,"displayName":2962,"givenName":28,"familyName":28},"e34f0f03-798e-496f-b127-af83429be978",[],[2952],{"id":2906,"sortIndex":32,"affiliation":2953,"properties":28},{"id":2906,"createTime":28,"updateTime":28,"relativeEntities":2954,"slug":28,"properties":2955,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2957,"statistic":28},[],{"title":2956},{"EN":2911},[],{"orcid":2959,"title":2961,"openalex":2963},{"VOID":2960},"https:\u002F\u002Forcid.org\u002F0000-0002-5860-0127",{"EN":2962},"Dan H. Moore",{"VOID":2964},"A5059617881",{"url":28,"publisher":2966,"properties":2975},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2967,"slug":872,"properties":2968,"entityType":25,"verifyStatus":879,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2972,"manageAffiliations":2973,"indexDatabases":2974,"url":28,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"issn":2969,"title":2970,"eissn":2971},{"VOID":875},{"EN":872},{"VOID":878},[],[],[],{"issue":2976,"pages":2977,"volume":2979},{"VOID":2535},{"VOID":2978},"325-337",{"VOID":1048},101,{"total":2980,"publishYear":2982,"statisticByYear":2983},1980,{"2018":40},"1980-01-01",[],[2987,2990,2993,2996,2998,3001,3004,3007,3010,3013,3016,3019,3022,3024,3027,3030,3033,3036,3039,3041,3044,3046,3048,3050,3052,3055,3058,3061,3063],{"id":28,"text":2988,"url":28,"identifiers":2989},"10.1093\u002Fjnci\u002F58.6.1635",{"doi":2988},{"id":28,"text":2991,"url":28,"identifiers":2992},"Alhadeff B, 1976, Frequency and distribution of sister chromatid exchanges in human peripheral lymphocytes, Israel J Med Sci, 12, 1440",{},{"id":28,"text":2994,"url":28,"identifiers":2995},"10.1159\u002F000130765",{"doi":2994},{"id":28,"text":2853,"url":28,"identifiers":2997},{"doi":2853},{"id":28,"text":2999,"url":28,"identifiers":3000},"10.1016\u002F0027-5107(79)90114-3",{"doi":2999},{"id":28,"text":3002,"url":28,"identifiers":3003},"10.1007\u002FBF00446625",{"doi":3002},{"id":28,"text":3005,"url":28,"identifiers":3006},"Crossen PE, 1978, Cytogenetic studies of pesticide and herbicide sprayers, New Zealand Med J, 88, 192",{},{"id":28,"text":3008,"url":28,"identifiers":3009},"10.1016\u002F0014-4827(79)90171-X",{"doi":3008},{"id":28,"text":3011,"url":28,"identifiers":3012},"10.1016\u002FS0140-6736(77)91485-4",{"doi":3011},{"id":28,"text":3014,"url":28,"identifiers":3015},"10.1016\u002F0027-5107(77)90144-0",{"doi":3014},{"id":28,"text":3017,"url":28,"identifiers":3018},"10.1111\u002Fj.1601-5223.1976.tb01582.x",{"doi":3017},{"id":28,"text":3020,"url":28,"identifiers":3021},"Lambert B, 1978, Sister chromatid exchanges in lymphocyte cultures of patients receiving chemotherapy for malignant disorders, Cancer Treatment Rpts, 62, 1413",{},{"id":28,"text":2804,"url":28,"identifiers":3023},{"doi":2804},{"id":28,"text":3025,"url":28,"identifiers":3026},"Latt SA, 1977, Population Cytogenetics: Studies in Humans, 217",{},{"id":28,"text":3028,"url":28,"identifiers":3029},"10.1016\u002F0165-1218(79)90020-X",{"doi":3028},{"id":28,"text":3031,"url":28,"identifiers":3032},"10.1016\u002F0014-4827(78)90423-8",{"doi":3031},{"id":28,"text":3034,"url":28,"identifiers":3035},"Minkler J, 1978, An ultraviolet light source for consistent differential staining of sister chromatids, Stain Technol, 53, 359",{},{"id":28,"text":3037,"url":28,"identifiers":3038},"10.1007\u002FBF00402152",{"doi":3037},{"id":28,"text":2859,"url":28,"identifiers":3040},{"doi":2859},{"id":28,"text":3042,"url":28,"identifiers":3043},"10.1016\u002F0165-1218(79)90023-5",{"doi":3042},{"id":28,"text":2865,"url":28,"identifiers":3045},{"doi":2865},{"id":28,"text":2807,"url":28,"identifiers":3047},{"doi":2807},{"id":28,"text":2810,"url":28,"identifiers":3049},{"doi":2810},{"id":28,"text":2819,"url":28,"identifiers":3051},{"doi":2819},{"id":28,"text":3053,"url":28,"identifiers":3054},"10.1016\u002F0027-5107(76)90106-8",{"doi":3053},{"id":28,"text":3056,"url":28,"identifiers":3057},"10.1016\u002F0027-5107(78)90126-4",{"doi":3056},{"id":28,"text":3059,"url":28,"identifiers":3060},"Taylor JH, 1958, Sister chromatid exchanges in tritium‐labeled chromosomes, Genetics, 43, 515, 10.1093\u002Fgenetics\u002F43.3.515",{"doi":2849},{"id":28,"text":2653,"url":28,"identifiers":3062},{"doi":2653},{"id":28,"text":3064,"url":28,"identifiers":3065},"10.1007\u002FBF00290991",{"doi":3064},{"id":3067,"createTime":3068,"updateTime":3068,"relativeEntities":3069,"slug":3070,"properties":3071,"entityType":905,"verifyStatus":26,"verifyTime":3068,"verifyNote":906,"languages":3084,"translateLanguages":28,"viewCount":32,"primaryUrl":3085,"fullTextUrl":28,"authors":3086,"publicationType":1035,"publisherRelationship":3138,"citationCount":601,"citationInfo":3153,"publishDate":1057,"publishYear":1055,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":3155,"openAccess":28,"references":3156,"isForceReanalyzing":1277},"cdae2432-e4ab-4b9e-bc33-e08d5abec798","2024-12-06T07:46:13.606+00:00",[],"The-genetic-toxicology-of-metal-compounds-I-Induction-of-%CE%BB-prophage-in-i-E-coli-i-WP2-sub-S-sub-%CE%BB-",{"openalex":3072,"mag":3074,"abstract":3076,"title":3078,"pm":3080,"doi":3082},{"VOID":3073},"W2060211227",{"VOID":3075},"2060211227",{"EN":3077},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>A number of metal compounds have been shown to be human carcinogens. Others, while not proven human carcinogens, are able to cause tumors in laboratory animals. Short‐term bacterial assays for genotoxic effects have not been successful in predicting the carcinogenicity of metal compounds. We report here the ability of some metal compounds to cause the induction of λ prophage in \u003Cjats:italic>E coli\u003C\u002Fjats:italic> WP2\u003Cjats:sub>S\u003C\u002Fjats:sub>(λ). By far the strongest inducing ability was observed with K2CrO4, followed by Pb(N0\u003Cjats:sub>3\u003C\u002Fjats:sub>)\u003Cjats:sub>2\u003C\u002Fjats:sub> > MnCl\u003Cjats:sub>2\u003C\u002Fjats:sub> > Ni(OOCCH\u003Cjats:sub>3\u003C\u002Fjats:sub>)\u003Cjats:sub>2\u003C\u002Fjats:sub> > CrCl\u003Cjats:sub>2\u003C\u002Fjats:sub> > NaWO\u003Cjats:sub>4\u003C\u002Fjats:sub> > Na\u003Cjats:sub>2\u003C\u002Fjats:sub>MoO\u003Cjats:sub>4\u003C\u002Fjats:sub> > KMnO\u003Cjats:sub>4\u003C\u002Fjats:sub>. With the exception of chromate, long‐term exposures in a narrow, subtoxic dose range were required in order to demonstrate phage induction. A new microtiter assay for λ prophage induction, which incorporates these features, is described. This system also was able to detect very small amounts of organic carcinogens.\u003C\u002Fjats:p>",{"EN":3079},"The genetic toxicology of metal compounds: I. 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In vitro studies, Drug Metab Dispos, 8, 376",{},{"id":28,"text":3473,"url":28,"identifiers":3474},"10.1007\u002FBF01538862",{"doi":3473},{"id":28,"text":3476,"url":28,"identifiers":3477},"10.1016\u002F0027-5107(80)90203-1",{"doi":3476},{"id":28,"text":3479,"url":28,"identifiers":3480},"10.1016\u002F0165-7992(83)90186-0",{"doi":3479},{"id":28,"text":3482,"url":28,"identifiers":3483},"10.1016\u002F0041-008X(80)90217-3",{"doi":3482},{"id":28,"text":2556,"url":28,"identifiers":3485},{"doi":2556},{"id":28,"text":3487,"url":28,"identifiers":3488},"10.1016\u002F0165-1161(79)90125-0",{"doi":3487},{"id":28,"text":3490,"url":28,"identifiers":3491},"Guengerich FP, 1981, In vitro metabolism of acrylonitrile to 2‐cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acids, Cancer Res, 41, 4925",{},{"id":28,"text":3493,"url":28,"identifiers":3494},"10.5271\u002Fsjweh.2414",{"doi":3493},{"id":28,"text":3496,"url":28,"identifiers":3497},"10.5271\u002Fsjweh.2649",{"doi":3496},{"id":28,"text":2601,"url":28,"identifiers":3499},{"doi":2601},{"id":28,"text":3501,"url":28,"identifiers":3502},"10.1016\u002F0378-4274(81)90056-4",{"doi":3501},{"id":28,"text":3504,"url":28,"identifiers":3505},"10.1016\u002F0006-2952(69)90237-8",{"doi":3504},{"id":28,"text":3507,"url":28,"identifiers":3508},"10.1016\u002F0165-1218(78)90020-4",{"doi":3507},{"id":28,"text":3510,"url":28,"identifiers":3511},"10.5271\u002Fsjweh.2760",{"doi":3510},{"id":28,"text":3513,"url":28,"identifiers":3514},"Maltoni C, 1977, Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion, Med Lab, 68, 401",{},{"id":28,"text":3516,"url":28,"identifiers":3517},"10.3109\u002F00498258209046787",{"doi":3516},{"id":28,"text":2619,"url":28,"identifiers":3519},{"doi":2619},{"id":28,"text":3521,"url":28,"identifiers":3522},"McFee AF, 1984, Influence of time on the in vivo induction of sister chromatid exchanges and chromosome aberrations, Environ Mutagen, 6, 156",{},{"id":28,"text":3524,"url":28,"identifiers":3525},"10.5271\u002Fsjweh.2739",{"doi":3524},{"id":28,"text":3527,"url":28,"identifiers":3528},"10.1016\u002F0027-5107(77)90209-3",{"doi":3527},{"id":28,"text":3530,"url":28,"identifiers":3531},"10.1016\u002F0378-4274(80)90066-1",{"doi":3530},{"id":28,"text":3533,"url":28,"identifiers":3534},"Norppa H, 1983, Metabolic activation of styrene by erythrocytes detected as increased sister chromatid exchanges in cultured human lymphocytes, Cancer Res, 43, 3579",{},{"id":28,"text":3536,"url":28,"identifiers":3537},"Nutt AR, 1984, Toxic Hazards of Rubber Chemicals, 1",{},{"id":28,"text":3539,"url":28,"identifiers":3540},"10.5271\u002Fsjweh.2464",{"doi":3539},{"id":28,"text":2810,"url":28,"identifiers":3542},{"doi":2810},{"id":28,"text":3544,"url":28,"identifiers":3545},"10.5271\u002Fsjweh.2754",{"doi":3544},{"id":28,"text":3547,"url":28,"identifiers":3548},"10.1016\u002F0009-2797(78)90050-9",{"doi":3547},{"id":28,"text":3550,"url":28,"identifiers":3551},"10.1016\u002F0165-1218(80)90072-5",{"doi":3550},{"id":28,"text":2631,"url":28,"identifiers":3553},{"doi":2631},{"id":28,"text":3555,"url":28,"identifiers":3556},"10.1016\u002F0009-2797(83)90081-9",{"doi":3555},{"id":28,"text":2634,"url":28,"identifiers":3558},{"doi":2634},{"id":28,"text":3560,"url":28,"identifiers":3561},"Sokal RR, 1969, Biometry: The Principles and Practice of Statistics in Biological Research",{},{"id":28,"text":3563,"url":28,"identifiers":3564},"10.1007\u002FBF00302526",{"doi":3563},{"id":28,"text":3566,"url":28,"identifiers":3567},"U.S. Environmental Protection Agency(1983):The reproductive effects assessment group's report on the mutagenicity of acrylonitrile. Health Assessment Document for Acrylonitrile EPA‐600\u002F8–82–007F pp13–71.",{},{"id":28,"text":3569,"url":28,"identifiers":3570},"10.1016\u002F0304-3835(82)90034-9",{"doi":3569},{"id":3572,"createTime":3573,"updateTime":3573,"relativeEntities":3574,"slug":3575,"properties":3576,"entityType":905,"verifyStatus":26,"verifyTime":3573,"verifyNote":906,"languages":3589,"translateLanguages":28,"viewCount":32,"primaryUrl":3590,"fullTextUrl":28,"authors":3591,"publicationType":1035,"publisherRelationship":3645,"citationCount":152,"citationInfo":3661,"publishDate":3664,"publishYear":3662,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":3665,"openAccess":28,"references":3666,"isForceReanalyzing":1277},"80814096-0df2-4661-88ed-d9ac46a240f7","2024-10-05T22:30:37.632+00:00",[],"Pesticide-induced-complete-and-partial-chromosome-loss-in-screens-with-repair-defective-females-of-drosophila-melanogaster",{"openalex":3577,"mag":3579,"abstract":3581,"title":3583,"pm":3585,"doi":3587},{"VOID":3578},"W2011245011",{"VOID":3580},"2011245011",{"EN":3582},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Commercial preparation of fungicides (captan and maneb), herbicides (bromacil, paraquat, picloram, and 2,4‐D), and insecticides (carbaryl, chlorpyrifos, dimethoate, DDT, diazinon, carbofuran, and permethrin) were tested for their ability to induce complete and partial chromosome losses in Drosophila melanogaster males. In an attempt to identify the mutagenic activity of pesticides that are toxic in low concentrations in Drosophila, these males were mated with mus‐302 repair‐defective females. The rationale for this mating scheme is based on the repair of genetic damage in Drosophila sperm by maternal enzymes in the zygote, and on the reports that there may be increases in the frequency of recovery of chemically induced chromosome losses in crosses of treated males with mus‐302 females. Verification of the sensitivity of this screen in this study came from significant increases in the frequency of chromosome loss induced by low concentrations of the positive controls. N‐nitrosodimethylamine and methyl methanesulfonate. Of the 13 pesticides, the insecticide chlorpyrifos induced a significant amount of ring‐X chromosome loss. No pesticide induced a significant increase in partial chromosome loss. These results are discussed in relation to the usefulness of repair‐defective mutants in screens for genetic damage in Drosophila and other higher eukaryotes by chemicals that are toxic or cause sterility at low concentrations.\u003C\u002Fjats:p>",{"EN":3584},"Pesticide‐induced complete and partial chromosome loss in screens with repair‐defective females of drosophila melanogaster",{"VOID":3586},"6418539",{"VOID":3588},"10.1002\u002Fem.2860050608",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860050608",[3592,3609,3628],{"id":3593,"sortIndex":32,"researcher":28,"roles":3594,"affiliations":3595,"properties":3604,"displayName":3606,"givenName":28,"familyName":28},"5256ecbf-7fbb-4d56-ae50-9d1cfc9ac6ba",[],[3596],{"id":3597,"sortIndex":32,"affiliation":3598,"properties":28},"1972530e-8250-4f38-ba24-e5ac6e62f775",{"id":3597,"createTime":28,"updateTime":28,"relativeEntities":3599,"slug":28,"properties":3600,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3603,"statistic":28},[],{"title":3601},{"EN":3602},"Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio",[],{"title":3605,"openalex":3607},{"EN":3606},"R. 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Carnegie Inst Wash Publ. 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There was a marginal increase in the incidence of structural chromosomal aberrations in first‐division metaphases in the styrene‐exposed workers, as compared with the nonexposed controls. However, there was no difference in SCE frequencies. When each group was divided into smokers and nonsmokers, styrene‐exposed smokers tended to have higher SCE frequencies than styrene‐exposed nonsmokers. Furthermore, cell proliferation was inhibited in styrene‐exposed workers (both smokers and nonsmokers) and control smokers.\u003C\u002Fjats:p>",{"EN":3757},"Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking 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Sym Toxicol, 16",{},{"id":28,"text":3976,"url":28,"identifiers":3977},"Šarrám RJ, 1981, Industrial and Environmental Xenobiotics. Metabolism and Pharmacokinetics of Organic Chemicals and Metals, 187",{},{"id":28,"text":3979,"url":28,"identifiers":3980},"10.1097\u002F00043764-197811000-00006",{"doi":3979},{"id":28,"text":3982,"url":28,"identifiers":3983},"10.1002\u002Fajim.4700010211",{"doi":3982},{"id":28,"text":3985,"url":28,"identifiers":3986},"10.1002\u002Fajim.4700030216",{"doi":3985},{"id":28,"text":3988,"url":28,"identifiers":3989},"10.1016\u002F0165-1161(80)90060-6",{"doi":3988},{"id":28,"text":3991,"url":28,"identifiers":3992},"Valadaud‐Barrieu D, 1979, Action de la phase gazeuse de fumée de cigarette sur le taux d'échanges des chromatides‐soeurs du lymphocyte humain in vitro, CR Acad Se (Paris), 288, 899",{},{"id":28,"text":3994,"url":28,"identifiers":3995},"10.1016\u002F0027-5107(82)90234-2",{"doi":3994},{"id":28,"text":3997,"url":28,"identifiers":3998},"10.1111\u002Fj.1399-0004.1981.tb01056.x",{"doi":3997},{"id":28,"text":4000,"url":28,"identifiers":4001},"10.1007\u002FBF00377457",{"doi":4000},{"id":28,"text":4003,"url":28,"identifiers":4004},"10.2486\u002Findhealth.19.37",{"doi":4003},{"id":28,"text":4006,"url":28,"identifiers":4007},"WatanabeT.KasukawaT.EndoA(1983):Sister chromatid exchanges in lymphocytes from cigarette smokers. Jpn J Hum Genet (Abstr) 28 (in press).",{},{"id":4009,"createTime":4010,"updateTime":4010,"relativeEntities":4011,"slug":4012,"properties":4013,"entityType":905,"verifyStatus":26,"verifyTime":4010,"verifyNote":906,"languages":4026,"translateLanguages":28,"viewCount":32,"primaryUrl":4027,"fullTextUrl":28,"authors":4028,"publicationType":1035,"publisherRelationship":4063,"citationCount":196,"citationInfo":4078,"publishDate":4081,"publishYear":4079,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":4082,"openAccess":28,"references":4083,"isForceReanalyzing":1277},"59d2634b-5a62-4f7f-9c4d-b2e1124480a9","2024-10-07T07:42:42.983+00:00",[],"Sister-chromatid-exchanges-induced-in-rabbit-lymphocytes-by-ethylene-oxide-after-inhalation-exposure",{"openalex":4014,"mag":4016,"abstract":4018,"title":4020,"pm":4022,"doi":4024},{"VOID":4015},"W1967365304",{"VOID":4017},"1967365304",{"EN":4019},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Ethylene oxide, which is the simplest epoxide and an extremely important commercial compound, has been used by many investigators as a model compound to study mutagenicity by alkylation of DNA. Knowledge of in vivo dose‐effect relations under experimental conditions may provide further insight into the dynamics of the sister chromatid exchange (SCE) response. It may also provide information on temporal aspects of sampling design for human worker populations. Groups of four male New Zealand white rabbits were exposed in inhalation chambers to 0, 10, 50, and 250 parts per million (ppm) ethylene oxide for 6 hr a day, 5 days a week, for 12 weeks. Peripheral blood samples were taken before the start of exposure, at intervals during exposure, and up to 15 weeks after the end of exposure to measure SCE rates in peripheral lymphocytes as well as standard hematological endpoints. Additionally, the level of reduced glutathione (GSH) in liver and blood was measured in a set of concurrently exposed animals at the end of the 12‐week exposure. Results show that exposure to 10 ppm does not cause a detectable increase in SCE rates. However, exposure to 50 and 250 ppm does cause an increase in SCEs that decreases after exposure ends, but still remains above baseline levels 15 weeks after exposure. Hematological and GSH measurements did not differ between control and exposed groups. These results indicate that inhalation exposure to the mutagenic alkylating agent ethylene oxide results in a dose‐related SCE effect, and that SCE is a more sensitive indicator of exposure than either standard hematological end points or GSH levels.\u003C\u002Fjats:p>",{"EN":4021},"Sister chromatid exchanges induced in rabbit lymphocytes by ethylene oxide after inhalation exposure",{"VOID":4023},"7075577",{"VOID":4025},"10.1002\u002Fem.2860040204",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fem.2860040204",[4029,4046],{"id":4030,"sortIndex":32,"researcher":28,"roles":4031,"affiliations":4032,"properties":4041,"displayName":4043,"givenName":28,"familyName":28},"1ca4016a-4baa-4f2b-a89f-802864ebc9a4",[],[4033],{"id":4034,"sortIndex":32,"affiliation":4035,"properties":28},"9f528da9-23a4-4d61-a903-9e519a54238e",{"id":4034,"createTime":28,"updateTime":28,"relativeEntities":4036,"slug":28,"properties":4037,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":4040,"statistic":28},[],{"title":4038},{"VI":4039},"Department of Biomedical and Environmental Health Sciences School of Public Health, University of California, Berkeley",[],{"title":4042,"openalex":4044},{"EN":4043},"Janice W. Yager",{"VOID":4045},"A5103464205",{"id":4047,"sortIndex":40,"researcher":28,"roles":4048,"affiliations":4049,"properties":4058,"displayName":4060,"givenName":28,"familyName":28},"e2cc789c-0a65-4c15-a09d-e3cb45ed9ade",[],[4050],{"id":4051,"sortIndex":32,"affiliation":4052,"properties":28},"5ac1066a-c83f-4e39-89ef-c133157d9bd4",{"id":4051,"createTime":28,"updateTime":28,"relativeEntities":4053,"slug":28,"properties":4054,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":4057,"statistic":28},[],{"title":4055},{"EN":4056},"Toxic Hazards Research Unit, University of California, Irvine, at Wright-Patterson AFB, Dayton, Ohio",[],{"title":4059,"openalex":4061},{"EN":4060},"R. 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The Risk to Humans",{},{"id":28,"text":2801,"url":28,"identifiers":4112},{"doi":2801},{"id":28,"text":4114,"url":28,"identifiers":4115},"Ehrenberg L, 1967, Haematologic studies on persons occupationally exposed to ethylene oxide, Int Atomic Energy Agency Report SM, 92, 327",{},{"id":28,"text":4117,"url":28,"identifiers":4118},"10.1111\u002Fj.1601-5223.1957.tb03463.x",{"doi":4117},{"id":28,"text":4120,"url":28,"identifiers":4121},"10.1016\u002F0041-008X(77)90096-5",{"doi":4120},{"id":28,"text":4123,"url":28,"identifiers":4124},"Embree JW, 1975, Mutagenicity of ethylene oxide, Toxicol Appl Pharmacol, 33, 172",{},{"id":28,"text":4126,"url":28,"identifiers":4127},"Fjellstedt TA, 1973, Enzymatic conjugation of epoxides with glutathione, J Biol Chem, 248, 3702, 10.1016\u002FS0021-9258(19)43983-5",{"doi":4128},"10.1016\u002FS0021-9258(19)43983-5",{"id":28,"text":3011,"url":28,"identifiers":4130},{"doi":3011},{"id":28,"text":2672,"url":28,"identifiers":4132},{"doi":2672},{"id":28,"text":4134,"url":28,"identifiers":4135},"Melby EC, 1976, Handbook of Laboratory Animal Science",{},{"id":28,"text":4137,"url":28,"identifiers":4138},"10.1016\u002F0009-2797(76)90042-9",{"doi":4137},{"id":28,"text":4140,"url":28,"identifiers":4141},"10.1007\u002FBF00336584",{"doi":4140},{"id":28,"text":4143,"url":28,"identifiers":4144},"10.1007\u002FBF00336573",{"doi":4143},{"id":28,"text":4146,"url":28,"identifiers":4147},"10.1002\u002Fem.2860030409",{"doi":4146},{"id":28,"text":4149,"url":28,"identifiers":4150},"10.1016\u002F0165-1218(79)90105-8",{"doi":4149},{"id":28,"text":3927,"url":28,"identifiers":4152},{"doi":3927},{"id":28,"text":4154,"url":28,"identifiers":4155},"Lambert B, 1978, Sister chromatid exchanges in lymphocyte cultures of patients receiving chemotherapy for malignant disorders, Cancer Treatment Rep, 62, 1413",{},{"id":28,"text":4157,"url":28,"identifiers":4158},"LeidelNA BuschKA LynchJR(1977):Occupational exposure sampling strategy manual. NIOSH January 1977 DHEW Publ No 77–173.",{},{"id":28,"text":4160,"url":28,"identifiers":4161},"10.1016\u002F0304-4165(79)90289-7",{"doi":4160},{"id":28,"text":4163,"url":28,"identifiers":4164},"Nakao Y, 1961, Test of a possible correlation between crosslinking and chromosome breaking abilities of chemical mutagens, Z Vererbungsl, 93, 356",{},{"id":28,"text":2865,"url":28,"identifiers":4166},{"doi":2865},{"id":28,"text":4168,"url":28,"identifiers":4169},"10.1007\u002F978-1-4613-3072-1_1",{"doi":4168},{"id":28,"text":2807,"url":28,"identifiers":4171},{"doi":2807},{"id":28,"text":2819,"url":28,"identifiers":4173},{"doi":2819},{"id":28,"text":4175,"url":28,"identifiers":4176},"10.1016\u002F0041-008X(75)90274-4",{"doi":4175},{"id":28,"text":4178,"url":28,"identifiers":4179},"10.1016\u002F0003-2697(68)90092-4",{"doi":4178},{"id":28,"text":3053,"url":28,"identifiers":4181},{"doi":3053},{"id":28,"text":3056,"url":28,"identifiers":4183},{"doi":3056},{"id":28,"text":4185,"url":28,"identifiers":4186},"Use of ethylene oxide as a sterilant in medical facilities. DHEW (NIOSH) Publ No 77–200 August 1977.",{},{"id":28,"text":4188,"url":28,"identifiers":4189},"10.1016\u002F0300-483X(76)90002-0",{"doi":4188},{"id":28,"text":4191,"url":28,"identifiers":4192},"Weisbroth SH, 1974, The Biology of the Laboratory Rabbit, 57",{}]