[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_73eab956-47bc-4d41-8022-acb8c32305bf":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:73eab956-47bc-4d41-8022-acb8c32305bf,\"}":106},{"code":4,"data":5,"meta":20},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":22,"manageAffiliations":29,"indexDatabases":44,"url":20,"thumbnailPath":20,"statistic":79,"gsStatistic":20,"type":20,"analyzePriority":20},"73eab956-47bc-4d41-8022-acb8c32305bf","2024-04-15T03:07:06.181+00:00","2025-11-21T10:00:59.476+00:00",[],"Walter-de-Gruyter-GmbH",{"issn":12,"title":14,"eissn":16},{"VOID":13},"2081-3856",{"EN":15},"Walter de Gruyter GmbH",{"VOID":17},"2081-6936","PUBLISHER","PENDING",null,0,[23],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":25,"label":26,"description":28,"parentId":20,"standard":20,"scholarHubFieldId":20},"ad2df4fc-f3aa-41d5-b713-331b2df73f42",[],{"EN":27},"Neuroscience (miscellaneous)",{},[30,37],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":32,"slug":20,"properties":33,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":36,"statistic":20},"1eac249d-faac-4d64-9561-18de823b9469",[],{"title":34},{"EN":35},"De Gruyter Open Ltd.",[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":39,"slug":20,"properties":40,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":43,"statistic":20},"dd38bcd5-5730-4d47-8066-b349c431799c",[],{"title":41},{"EN":42},"DE GRUYTER POLAND SP Z O O",[],[45,62],{"id":46,"indexDatabase":47,"url":57,"indexYears":58,"academicFieldIds":59,"indexDatabaseRanking":61},"181b96ef-ebdd-46c4-a35f-b129250a9c8f",{"id":48,"createTime":20,"updateTime":20,"relativeEntities":49,"label":50,"description":52,"key":54,"publicationTags":55,"standard":20},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":51,"VI":51},"Scopus - Elsevier",{"EN":51,"VI":53},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[56],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F19700188483","2010-2025",[60],"fcfab063-8c6c-4582-8a75-e1ae02713ec5","SCOPUS__Q3",{"id":63,"indexDatabase":64,"url":76,"indexYears":20,"academicFieldIds":77,"indexDatabaseRanking":20},"a8c80499-0bed-4823-93f6-ef589da090ac",{"id":65,"createTime":20,"updateTime":20,"relativeEntities":66,"label":67,"description":69,"key":72,"publicationTags":73,"standard":20},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":68,"VI":68},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":70,"VI":71},"SCIE database","Cơ sở dữ liệu SCIE","scie",[74,75],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=2081-3856",[78],"8d10567b-4ae4-42f8-b554-ff4a4364e08f",{"impactFactor":21,"impactFactorByYear":80,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":88,"totalCitation":93,"totalCitationByYear":94,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":99,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},0.09,0.16,0.21,0.15,0.12,6,144,{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},27,28,35,26,203,{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},31,44,76,1.41,{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},0.96,1.11,1.57,2.17,1,7,{"meta":107,"data":109},{"total":108},"145",[110,272,719,942,1172,1255,1349,1521,1676,1756],{"id":111,"createTime":112,"updateTime":113,"relativeEntities":114,"slug":115,"properties":116,"entityType":125,"verifyStatus":126,"verifyTime":113,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":128,"fullTextUrl":20,"authors":129,"publicationType":219,"publisherRelationship":220,"citationCount":20,"citationInfo":20,"publishDate":268,"publishYear":269,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":270,"openAccess":20,"references":20,"isForceReanalyzing":271},"a06cca8f-cb00-47ed-b49a-0caeb44996c3","2023-12-05T05:25:19.706+00:00","2025-02-25T19:46:59.377+00:00",[],"Amyloid-imaging-in-Alzheimer-s-disease-a-potential-new-era-of-personalized-medicine-",{"abstract":117,"title":119,"references":121,"doi":123},{"EN":118},"Recent advances along clinical and neuropathological lines, as well as in our ability to detect the deposition of β-amyloid (Aβ) in vivo using positron emission tomography (PET), have helped redefine Alzheimer’s disease (AD) as a dynamic clinicobiological entity. On the basis of these advances, AD is now conceptualized as a continuum comprising asymptomatic, minimally symptomatic, and dementia phases, with detection of brain Aβ — in particular, via PET amyloid imaging — central to the diagnostic process. In this respect, [18F]florbetapir (Amyvid™) and [18F]flutemetamol (Vizamyl™) have recently received approval for clinical use from the Food and Drug Administration (FDA) and the European Medicines Agency (EMA), with additional radiofluorinated tracers for detection of Aβ in phase III trials. Recent initiatives such as the Alzheimer’s Disease Neuroimaging Initiative (ADNI) suggest that Aβ production, oligomerization and aggregation begins many years, possibly decades, before detectable cognitive impairment, with Aβ shown to associate with cognitive decline and conversion to dementia. While personalized medicine has now emerged as a prospect for the field, the recent decision by the Centers for Medicare & Medicaid Services (CMS) — who declined to cover the cost of amyloid PET imaging citing insufficient evidence to support its clinical utility — highlights that such a move may be premature.",{"EN":120},"Amyloid imaging in Alzheimer’s disease: a potential new era of personalized medicine?",{"VOID":122},"McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M., Clinical diagnosis of Alzheimer’s disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease, Neurology, 1984, 34, 939–94\nDubois B., Feldman H.H., Jacova C., Cummings J.L., Dekosky S.T., Barberger-Gateau P., et al., Revising the definition of Alzheimer’s disease: a new lexicon, Lancet Neurol., 2010, 9, 1118–1127\nDubois B., Feldman H.H., Jacova C., Dekosky S.T., Barberger-Gateau P., Cummings J., et al., Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria, Lancet Neurol., 2007, 6, 734–746\nSperling R.A., Aisen P.S., Beckett L.A., Bennett D.A., Craft S., Fagan A.M., et al., Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease, Alzheimers Dement., 2011, 7, 280–292\nAlbert M.S., DeKosky S.T., Dickson D., Dubois B., Feldman H.H., Fox N.C., et al., The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease, Alzheimers Dement., 2011, 7, 270–279\nMcKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Jr., Kawas C.H., et al., The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease, Alzheimers Dement., 2011, 7, 263–269\nVarma A.R., Snowden J.S., Lloyd J.J., Talbot P.R., Mann D.M., Neary D., Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer’s disease and frontotemporal dementia, J. Neurol. Neurosurg. Psychiatry, 1999, 66, 184–188\nKazee A.M., Eskin T.A., Lapham L.W., Gabriel K.R., McDaniel K.D., Hamill R.W., Clinicopathologic correlates in Alzheimer disease: assessment of clinical and pathologic diagnostic criteria, Alzheimer Dis. Assoc. Disord., 1993, 7, 152–164\nBiomarkers Definitions Working G., Biomarkers and surrogate endpoints: preferred definitions and conceptual framework, Clin. Pharmacol. Ther., 2001, 69, 89–95\nHardy J., Selkoe D.J., The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics, Science, 2002, 297, 353–356\nFagan A.M., Mintun M.A., Shah A.R., Aldea P., Roe C.M., Mach R.H., et al., Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer’s disease, EMBO Mol. Med., 2009, 1, 371–380\nMorris J.C., Roe C.M., Xiong C., Fagan A.M., Goate A.M., Holtzman D.M., et al., APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging, Ann. Neurol., 2010, 67, 122–131\nFagan A.M., Mintun M.A., Mach R.H., Lee S.Y., Dence C.S., Shah A.R., et al., Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans, Ann. Neurol., 2006, 59, 512–519\nKoivunen J., Pirttila T., Kemppainen N., Aalto S., Herukka S.K., Jauhianen A.M., et al., PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment, Dement. Geriatr. Cogn. Disord., 2008, 26, 378–383\nForsberg A., Almkvist O., Engler H., Wall A., Langstrom B., Nordberg A., High PIB retention in Alzheimer’s disease is an early event with complex relationship with CSF biomarkers and functional parameters, Curr. Alzheimer Res., 2010, 7, 56–66\nLandau S.M., Lu M., Joshi A.D., Pontecorvo M., Mintun M.A., Trojanowski J.Q., et al., Comparing positron emission tomography imaging and cerebrospinal fluid measurements of beta-amyloid, Ann. Neurol., 2013, 74, 826–836\nMattsson N., Blennow K., Zetterberg H., Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer’s disease: united we stand, divided we fall, Clin. Chem. Lab. Med., 2010, 48, 603–607\nNordberg A., Carter S.F., Rinne J., Drzezga A., Brooks D.J., Vandenberghe R., et al., A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease, Eur. J. Nucl. Med. Mol. Imaging, 2013, 40, 104–114\nVandenberghe R., Adamczuk K., Dupont P., Laere K.V., Chételat G., Amyloid PET in clinical practice: its place in the multidimensional space of Alzheimer’s disease, Neuroimage. Clin., 2013, 2, 497–511\nCohen A.D., Rabinovici G.D., Mathis C.A., Jagust W.J., Klunk W.E., Ikonomovic M.D., Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta, Adv. Pharmacol., 2012, 64, 27–81\nPrice J.C., Klunk W.E., Lopresti B.J., Lu X., Hoge J.A., Ziolko S.K., et al., Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B, J. Cereb. Blood Flow Metab., 2005, 25, 1528–1547\nLockhart A., Lamb J.R., Osredkar T., Sue L.I., Joyce J.N., Ye L., et al., PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptiderelated cerebral amyloidosis, Brain, 2007, 130, 2607–2615\nMaezawa I., Hong H.S., Liu R., Wu C.Y., Cheng R.H., Kung M.P., et al., Congo red and thioflavin-T analogs detect Abeta oligomers, J. Neurochem., 2008, 104, 457–468\nKemppainen N.M., Aalto S., Wilson I.A., Nagren K., Helin S., Bruck A., et al., PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment, Neurology, 2007, 68, 1603–1606\nKlunk W.E., Engler H., Nordberg A., Wang Y., Blomqvist G., Holt D.P., et al., Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B, Ann. Neurol., 2004, 55, 306–319\nForsberg A., Engler H., Almkvist O., Blomquist G., Hagman G., Wall A., et al., PET imaging of amyloid deposition in patients with mild cognitive impairment, Neurobiol. Aging, 2008, 29, 1456–1465\nOkello A., Koivunen J., Edison P., Archer H.A., Turkheimer F.E., Nagren K., et al., Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study, Neurology, 2009, 73, 754–760\nJagust W.J., Bandy D., Chen K., Foster N.L., Landau S.M., Mathis C.A., et al., The Alzheimer’s Disease Neuroimaging Initiative positron emission tomography core, Alzheimers Dement., 2010, 6, 221–229\nResnick S.M., Sojkova J., Amyloid imaging and memory change for prediction of cognitive impairment, Alzheimers Res.Ther., 2011, 3, 3\nRowe C.C., Ellis K.A., Rimajova M., Bourgeat P., Pike K.E., Jones G., et al., Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, Neurobiol. Aging, 2010, 31, 1275–1283\nMintun M.A., Larossa G.N., Sheline Y.I., Dence C.S., Lee S.Y., Mach R.H., et al., [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease, Neurology, 2006, 67, 446–452\nRowe C.C., Ng S., Ackermann U., Gong S.J., Pike K., Savage G., et al., Imaging beta-amyloid burden in aging and dementia, Neurology, 2007, 68, 1718–1725\nNg S.Y., Villemagne V.L., Masters C.L., Rowe C.C., Evaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh Compound B, Arch. Neurol., 2007, 64, 1140–1144\nRabinovici G.D., Furst A.J., O’Neil J.P., Racine C.A., Mormino E.C., Baker S.L., et al., 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration, Neurology, 2007, 68, 1205–1212\nRowe C.C., Ackerman U., Browne W., Mulligan R., Pike K.L., O’Keefe G., et al., Imaging of amyloid beta in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism, Lancet Neurol., 2008, 7, 129–135\nClark C.M., Pontecorvo M.J., Beach T.G., Bedell B.J., Coleman R.E., Doraiswamy P.M., et al., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-beta plaques: a prospective cohort study, Lancet Neurol., 2012, 11, 669–678\nWolk D.A., Grachev I.D., Buckley C., Kazi H., Grady M.S., Trojanowski J.Q., et al., Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology, Arch. Neurol., 2011, 68, 1398–1403\nCselenyi Z., Jonhagen M.E., Forsberg A., Halldin C., Julin P., Schou M., et al., Clinical validation of 18F-AZD4694, an amyloid-beta-specific PET radioligand, J. Nucl. Med., 2012, 53, 415–424\nIkonomovic M.D., Klunk W.E., Abrahamson E.E., Mathis C.A., Price J.C., Tsopelas N.D., et al., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease, Brain, 2008, 131, 1630–1645\nClark C.M., Schneider J.A., Bedell B.J., Beach T.G., Bilker W.B., Mintun M.A., et al., Use of florbetapir-PET for imaging beta-amyloid pathology, JAMA, 2011, 305, 275–283\nZimmer E., Parent M., Leuzy A., Rowley J., Cheewakriengkrai L., Shin M., et al., [18F]NAV4694 shows higher binding and wider dynamic range compared with [11C]PiB in Alzheimer’s disease postmortem tissue, Alzheimers Dement., 2013, 9, P22–P23\nJohnson K.A., Minoshima S., Bohnen N.I., Donohoe K.J., Foster N.L., Herscovitch P., et al., Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association, Alzheimers Dement., 2013, 9, e-1–16\nJohnson K.A., Fox N.C., Sperling R.A., Klunk W.E., Brain imaging in Alzheimer disease, Cold Spring Harb. Perspect. Med., 2012, 2, a006213\nOlson S., Institute of Medicine (U.S.). Roundtable on translating genomic-based research for health., Institute of Medicine (U.S.). Board on Health Sciences Policy., Integrating large-scale genomic information into clinical practice: workshop summary, National Academies Press, Washington, D.C., 2012\nHood L., Flores M., A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory, N. Biotechnol., 2012, 29, 613–624\nSnyderman R., Personalized health care: from theory to practice, Biotechnol. J., 2012, 7, 973–979\nWeiner M.W., Veitch D.P., Aisen P.S., Beckett L.A., Cairns N.J., Green R.C., et al., The Alzheimer’s Disease Neuroimaging Initiative: a review of papers published since its inception, Alzheimers Dement., 2012, 8, S1–68\nEllis K.A., Bush A.I., Darby D., De Fazio D., Foster J., Hudson P., et al., The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer’s disease, Int. Psychogeriatr., 2009, 21, 672–687\nPike K.E., Savage G., Villemagne V.L., Ng S., Moss S.A., Maruff P., et al., Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer’s disease, Brain, 2007, 130, 2837–2844\nJack C.R., Jr., Lowe V.J., Senjem M.L., Weigand S.D., Kemp B.J., Shiung M.M., et al., 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment, Brain, 2008, 131, 665–680\nAizenstein H.J., Nebes R.D., Saxton J.A., Price J.C., Mathis C.A., Tsopelas N.D., et al., Frequent amyloid deposition without significant cognitive impairment among the elderly, Arch. Neurol., 2008, 65, 1509–1517\nMormino E.C., Kluth J.T., Madison C.M., Rabinovici G.D., Baker S.L., Miller B.L., et al., Episodic memory loss is related to hippocampalmediated beta-amyloid deposition in elderly subjects, Brain, 2009, 132, 1310–1323\nStorandt M., Mintun M.A., Head D., Morris J.C., Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition, Arch. Neurol., 2009, 66, 1476–1481\nVillemagne V.L., Pike K.E., Chetelat G., Ellis K.A., Mulligan R.S., Bourgeat P., et al., Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease, Ann. Neurol., 2011, 69, 181–192\nLandau S.M., Mintun M.A., Joshi A.D., Koeppe R.A., Petersen R.C., Aisen P.S., et al., Amyloid deposition, hypometabolism, and longitudinal cognitive decline, Ann. Neurology, 2012, 72, 578–586\nJack C.R., Jr., Wiste H.J., Vemuri P., Weigand S.D., Senjem M.L., Zeng G., et al., Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer’s disease, Brain, 2010, 133, 3336–3348\nWolk D.A., Price J.C., Saxton J.A., Snitz B.E., James J.A., Lopez O.L., et al., Amyloid imaging in mild cognitive impairment subtypes, Ann. Neurol., 2009, 65, 557–568\nTrzepacz P.T., Yu P., Sun J., Schuh K., Case M., Witte M.M., et al., Comparison of neuroimaging modalities for the prediction of conversion from mild cognitive impairment to Alzheimer’s dementia, Neurobiol. Aging, 2014, 35, 143–151\nGreen R.C., Roberts J.S., Cupples L.A., Relkin N.R., Whitehouse P.J., Brown T., et al., Disclosure of APOE genotype for risk of Alzheimer’s disease, N. Engl. J. Med., 2009, 361, 245–254\nSteinbrook R., The Centers for Medicare & Medicaid Services and amyloid-beta positron emission tomography for Alzheimer disease, JAMA Intern. Med., 2014, 174, 135\nPearson S.D., Ollendorf D.A., Colby J.A., Amyloid-beta positron emission tomography in the diagnostic evaluation of Alzheimer disease: summary of primary findings and conclusions, JAMA Intern. Med., 2014, 174, 133–134\nDoraiswamy P.M., Sperling R.A., Coleman R.E., Johnson K.A., Reiman E.M., Davis M.D., et al., Amyloid-beta assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study, Neurology, 2012, 79, 1636–1644\nGarber K., First FDA-approved beta-amyloid diagnostic hits the market, Nat. Biotechnol., 2012, 30, 575\nLeuzy A., Gauthier S., Ethical issues in Alzheimer’s disease: an overview, Expert Rev. Neurother., 2012, 12, 557–567\nLineweaver T.T., Bondi M.W., Galasko D., Salmon D.P., Effect of knowledge of APOE genotype on subjective and objective memory performance in healthy older adults, Am. J. Psychiatry, 2014, 171, 201–208\nKarlawish J., Green R.C., Minding the aging brain: are we ready for personalized medicine?, Am. J. Psychiatry, 2014, 171, 137–139",{"VOID":124},"10.2478\u002Fs13380-014-0205-y","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-014-0205-y\u002Fhtml",[130,155,185,198],{"id":131,"sortIndex":21,"researcher":20,"roles":132,"affiliations":134,"properties":152,"displayName":154,"givenName":20,"familyName":20},"2553980a-ecb1-4cc3-b09a-c109d2a7c523",[133],"AUTHOR",[135,143],{"id":136,"sortIndex":21,"affiliation":137,"properties":20},"e437ec58-f1c6-47a0-92aa-22b3e46da007",{"id":136,"createTime":20,"updateTime":20,"relativeEntities":138,"slug":20,"properties":139,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":142,"statistic":20},[],{"title":140},{"VI":141},"Translational Neuroimaging Laboratory (TNL), McGill Centre for Studies in Aging (MCSA), Douglas Mental Health University Institute, Montreal, Canada",[],{"id":144,"sortIndex":104,"affiliation":145,"properties":151},"0bcfb9c0-6cb1-4369-a010-cdd1bc75fa36",{"id":144,"createTime":20,"updateTime":20,"relativeEntities":146,"slug":20,"properties":147,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":150,"statistic":20},[],{"title":148},{"VI":149},"Alzheimer’s Disease Research Unit, MCSA, Douglas Mental Health University Institute, Montreal, Canada",[],{},{"title":153},{"VI":154},"Antoine Leuzy",{"id":156,"sortIndex":104,"researcher":20,"roles":157,"affiliations":158,"properties":182,"displayName":184,"givenName":20,"familyName":20},"2905de68-60e8-4e26-abca-535e666e42ef",[133],[159,165,172],{"id":136,"sortIndex":21,"affiliation":160,"properties":20},{"id":136,"createTime":20,"updateTime":20,"relativeEntities":161,"slug":20,"properties":162,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":164,"statistic":20},[],{"title":163},{"VI":141},[],{"id":144,"sortIndex":104,"affiliation":166,"properties":171},{"id":144,"createTime":20,"updateTime":20,"relativeEntities":167,"slug":20,"properties":168,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":170,"statistic":20},[],{"title":169},{"VI":149},[],{},{"id":173,"sortIndex":174,"affiliation":175,"properties":181},"818aeaac-73fa-465d-86a6-eb7d618e5c10",2,{"id":173,"createTime":20,"updateTime":20,"relativeEntities":176,"slug":20,"properties":177,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":180,"statistic":20},[],{"title":178},{"VI":179},"Department of Biochemistry Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil",[],{},{"title":183},{"VI":184},"Eduardo Rigon Zimmer",{"id":186,"sortIndex":174,"researcher":20,"roles":187,"affiliations":188,"properties":195,"displayName":197,"givenName":20,"familyName":20},"d074aced-03b9-4a30-84e6-08772d877f73",[133],[189],{"id":136,"sortIndex":21,"affiliation":190,"properties":20},{"id":136,"createTime":20,"updateTime":20,"relativeEntities":191,"slug":20,"properties":192,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":194,"statistic":20},[],{"title":193},{"VI":141},[],{"title":196},{"VI":197},"Serge Gauthier",{"id":199,"sortIndex":200,"researcher":20,"roles":201,"affiliations":202,"properties":216,"displayName":218,"givenName":20,"familyName":20},"ae7c2262-8d4b-4a5d-a7f3-41e120736fe4",3,[133],[203,209],{"id":136,"sortIndex":21,"affiliation":204,"properties":20},{"id":136,"createTime":20,"updateTime":20,"relativeEntities":205,"slug":20,"properties":206,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":208,"statistic":20},[],{"title":207},{"VI":141},[],{"id":144,"sortIndex":104,"affiliation":210,"properties":215},{"id":144,"createTime":20,"updateTime":20,"relativeEntities":211,"slug":20,"properties":212,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":214,"statistic":20},[],{"title":213},{"VI":149},[],{},{"title":217},{"VI":218},"Pedro Rosa-Neto","ARTICLE",{"url":128,"publisher":221,"properties":263},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":222,"slug":10,"properties":223,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":227,"manageAffiliations":232,"indexDatabases":243,"url":20,"thumbnailPath":20,"statistic":258,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":224,"title":225,"eissn":226},{"VOID":13},{"EN":15},{"VOID":17},[228],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":229,"label":230,"description":231,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[233,238],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":234,"slug":20,"properties":235,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":237,"statistic":20},[],{"title":236},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":239,"slug":20,"properties":240,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":242,"statistic":20},[],{"title":241},{"EN":42},[],[244,251],{"id":46,"indexDatabase":245,"url":57,"indexYears":58,"academicFieldIds":250,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":246,"label":247,"description":248,"key":54,"publicationTags":249,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":252,"url":76,"indexYears":20,"academicFieldIds":257,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":253,"label":254,"description":255,"key":72,"publicationTags":256,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":259,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":260,"totalCitation":93,"totalCitationByYear":261,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":262,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":264,"volume":266},{"VOID":265},"51-56",{"VOID":267},"5","2014-03-28",2014,[61,74],false,{"id":273,"createTime":274,"updateTime":275,"relativeEntities":276,"slug":277,"properties":278,"entityType":125,"verifyStatus":126,"verifyTime":275,"verifyNote":127,"languages":293,"translateLanguages":295,"viewCount":21,"primaryUrl":297,"fullTextUrl":20,"authors":298,"publicationType":219,"publisherRelationship":350,"citationCount":393,"citationInfo":394,"publishDate":398,"publishYear":395,"citationAnalyzeStatus":399,"lastCitationAnalyze":400,"indexDatabases":401,"openAccess":20,"references":402,"isForceReanalyzing":271},"f2d673d2-90a5-403d-b42a-27f56a69935d","2024-04-14T13:34:43.786+00:00","2025-02-25T02:06:36.305+00:00",[],"Breath-hold-diving-as-a-brain-survival-response",{"openalex":279,"mag":281,"abstract":283,"title":286,"keywords":289,"doi":291},{"VOID":280},"W2067635831",{"VOID":282},"2067635831",{"EN":284,"VI":285},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Elite breath-hold divers are unique athletes challenged with compression induced by hydrostatic pressure and extreme hypoxia\u002Fhypercapnia during maximal field dives. The current world records for men are 214 meters for depth (Herbert Nitsch, No-Limits Apnea discipline), 11:35 minutes for duration (Stephane Mifsud, Static Apnea discipline), and 281 meters for distance (Goran Čolak, Dynamic Apnea with Fins discipline). The major physiological adaptations that allow breath-hold divers to achieve such depths and duration are called the “diving response” that is comprised of peripheral vasoconstriction and increased blood pressure, bradycardia, decreased cardiac output, increased cerebral and myocardial blood flow, splenic contraction, and preserved O2 delivery to the brain and heart. This complex of physiological adaptations is not unique to humans, but can be found in all diving mammals. Despite these profound physiological adaptations, divers may frequently show hypoxic loss of consciousness. The breath-hold starts with an easy-going phase in which respiratory muscles are inactive, whereas during the second so-called “struggle” phase, involuntary breathing movements start. These contractions increase cerebral blood flow by facilitating left stroke volume, cardiac output, and arterial pressure. The analysis of the compensatory mechanisms involved in maximal breath-holds can improve brain survival during conditions involving profound brain hypoperfusion and deoxygenation.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Các vận động viên lặn nín thở chuyên nghiệp là những vận động viên độc nhất đối mặt với áp lực do sức nước và tình trạng hạ oxy\u002Fhypercapnia cực độ trong các lần lặn tối đa. Kỷ lục thế giới hiện tại dành cho nam giới là 214 mét cho độ sâu (Herbert Nitsch, môn lặn nín thở không giới hạn), 11:35 phút cho thời gian (Stephane Mifsud, môn lặn nín thở tĩnh), và 281 mét cho khoảng cách (Goran Čolak, môn lặn nín thở động với vây). Những thích ứng sinh lý chính cho phép các vận động viên lặn nín thở đạt được độ sâu và thời gian như vậy được gọi là phản ứng \"lặn\" bao gồm co mạch ngoại biên và tăng huyết áp, nhịp tim chậm, giảm lưu lượng tim, tăng lưu lượng máu não và cơ tim, co tỳ, và duy trì cung cấp O2 cho não và tim. Tổ hợp các thích ứng sinh lý này không chỉ riêng có ở con người mà còn tồn tại ở tất cả các loài động vật có vú lặn. Mặc dù có những thích ứng sinh lý sâu sắc này, các vận động viên lặn có thể thường xuyên gặp tình trạng mất ý thức do thiếu oxy. Quá trình lặn nín thở bắt đầu với một giai đoạn dễ chịu trong đó các cơ hô hấp không hoạt động, trong khi trong giai đoạn thứ hai được gọi là \"giai đoạn đấu tranh\", các chuyển động thở không tự nguyện bắt đầu xảy ra. Những co thắt này làm tăng lưu lượng máu não bằng cách thúc đẩy khối lượng bơm máu của tâm thất trái, lưu lượng tim, và huyết áp động mạch. Phân tích các cơ chế bù trừ tham gia vào các lần lặn nín thở tối đa có thể cải thiện khả năng sống sót của não trong các điều kiện liên quan đến tình trạng thiếu máu não sâu và thiếu oxy.",{"EN":287,"VI":288},"Breath-hold diving as a brain survival response","Lặn nín thở như một phản ứng sinh tồn của não",{"VI":290},"",{"VOID":292},"10.2478\u002Fs13380-013-0130-5",[294],"EN",[296],"VI","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-013-0130-5\u002Fhtml",[299,318,335],{"id":300,"sortIndex":21,"researcher":20,"roles":301,"affiliations":302,"properties":311,"displayName":315,"givenName":20,"familyName":20},"dd72ecb0-44a4-441a-adf7-2e7b7595e63c",[],[303],{"id":304,"sortIndex":21,"affiliation":305,"properties":20},"03985732-ec5e-410e-9404-f9fa810a9389",{"id":304,"createTime":20,"updateTime":20,"relativeEntities":306,"slug":20,"properties":307,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":310,"statistic":20},[],{"title":308},{"VI":309},"Department of Integrative Physiology, University of Split School of Medicine, Split, Croatia",[],{"orcid":312,"title":314,"openalex":316},{"VOID":313},"https:\u002F\u002Forcid.org\u002F0000-0002-6450-0130",{"EN":315},"Željko Dujić",{"VOID":317},"A5014380719",{"id":319,"sortIndex":104,"researcher":20,"roles":320,"affiliations":321,"properties":328,"displayName":332,"givenName":20,"familyName":20},"2eb28433-7833-4dc7-9df5-8e152566ceb7",[],[322],{"id":304,"sortIndex":21,"affiliation":323,"properties":20},{"id":304,"createTime":20,"updateTime":20,"relativeEntities":324,"slug":20,"properties":325,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":327,"statistic":20},[],{"title":326},{"VI":309},[],{"orcid":329,"title":331,"openalex":333},{"VOID":330},"https:\u002F\u002Forcid.org\u002F0000-0001-7266-2087",{"EN":332},"Toni Brešković",{"VOID":334},"A5027222043",{"id":336,"sortIndex":174,"researcher":20,"roles":337,"affiliations":338,"properties":345,"displayName":347,"givenName":20,"familyName":20},"7be74488-4df2-4ab4-94f5-7dcbc74f590c",[],[339],{"id":304,"sortIndex":21,"affiliation":340,"properties":20},{"id":304,"createTime":20,"updateTime":20,"relativeEntities":341,"slug":20,"properties":342,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":344,"statistic":20},[],{"title":343},{"VI":309},[],{"title":346,"openalex":348},{"EN":347},"Darija Baković",{"VOID":349},"A5046337658",{"url":20,"publisher":351,"properties":20},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":352,"slug":10,"properties":353,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":357,"manageAffiliations":362,"indexDatabases":373,"url":20,"thumbnailPath":20,"statistic":388,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":354,"title":355,"eissn":356},{"VOID":13},{"EN":15},{"VOID":17},[358],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":359,"label":360,"description":361,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[363,368],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":364,"slug":20,"properties":365,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":367,"statistic":20},[],{"title":366},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":369,"slug":20,"properties":370,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":372,"statistic":20},[],{"title":371},{"EN":42},[],[374,381],{"id":46,"indexDatabase":375,"url":57,"indexYears":58,"academicFieldIds":380,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":376,"label":377,"description":378,"key":54,"publicationTags":379,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":382,"url":76,"indexYears":20,"academicFieldIds":387,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":383,"label":384,"description":385,"key":72,"publicationTags":386,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":389,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":390,"totalCitation":93,"totalCitationByYear":391,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":392,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},8,{"total":393,"publishYear":395,"statisticByYear":396},2013,{"2014":104,"2016":104,"2017":397,"2019":104},5,"2013-01-01","ERROR_IN_ANALYZE_CITATION","2024-04-15T03:14:42.190+00:00",[61,74],[403,407,411,415,419,422,426,430,433,437,441,445,449,453,457,461,465,468,472,476,480,484,488,492,496,500,504,508,512,516,519,523,527,531,535,539,543,547,551,555,559,563,567,571,575,579,583,587,591,595,599,603,606,609,612,616,620,624,628,632,636,640,644,648,652,656,660,664,668,672,676,680,684,688,692,695,699,703,707,711,715],{"id":20,"text":404,"url":20,"identifiers":405},"Lindholm P., Loss of motor control and\u002For loss of consciousness during breath-hold competitions, Int. J. Sports Med., 2007, 28, 295–299",{"doi":406},"10.1055\u002Fs-2006-924361",{"id":20,"text":408,"url":20,"identifiers":409},"Dujic Z., Breskovic T., Impact of breath holding on cardiovascular respiratory and cerebrovascular health, Sports Med., 2012, 42, 459–472",{"doi":410},"10.2165\u002F11599260-000000000-00000",{"id":20,"text":412,"url":20,"identifiers":413},"Muth C.M., Radermacher P., Pittner A., Steinacker J., Schabana R., Hamich S., et al., Arterial blood gases during diving in elite apnea divers, Int. J. Sports Med., 2003, 24, 104–107",{"doi":414},"10.1055\u002Fs-2003-38401",{"id":20,"text":416,"url":20,"identifiers":417},"Breskovic T., Uglesic L., Zubin P., Kuch B., Kraljevic J., Zanchi J., et al., Cardiovascular changes during underwater static and dynamic breath-hold dives in trained divers, J. Appl. Physiol, 2011, 111, 673–678",{"doi":418},"10.1152\u002Fjapplphysiol.00209.2011",{"id":20,"text":420,"url":20,"identifiers":421},"Kuch B., Koss B., Dujic Z., Buttazzo G., Sieber A., A novel wearable apnea dive computer for continuous plethysmographic monitoring of oxygen saturation and heart rate, Diving. Hyperb. Med., 2010, 40, 34–40",{},{"id":20,"text":423,"url":20,"identifiers":424},"Tocco F., Marongiu E., Pinna M., Roberto S., Pusceddu M., Angius L., et al., Assessment of circulatory adjustments during underwater apnoea in elite divers by means of a portable device, Acta. Physiol. (Oxf), 2013, 207, 290–298",{"doi":425},"10.1111\u002Fapha.12000",{"id":20,"text":427,"url":20,"identifiers":428},"Lindholm P., Nyren S., Studies on inspiratory and expiratory glossopharyngeal breathing in breath-hold divers employing magnetic resonance imaging and spirometry, Eur. J. Appl. Physiol, 2005, 94, 646–651",{"doi":429},"10.1007\u002Fs00421-005-1358-8",{"id":20,"text":431,"url":20,"identifiers":432},"Novalija J., Lindholm P., Loring S.H., Diaz E., Fox J.A., Ferrigno M., Cardiovascular aspects of glossopharyngeal insufflation and exsufflation, Undersea Hyperb. Med., 2007, 34, 415–423",{},{"id":20,"text":434,"url":20,"identifiers":435},"Ferrigno M., Hickey D.D., Liner M.H., Lundgren C.E., Cardiac performance in humans during breath holding, J. Appl. Physiol, 1986, 60, 1871–1877",{"doi":436},"10.1152\u002Fjappl.1986.60.6.1871",{"id":20,"text":438,"url":20,"identifiers":439},"Potkin R., Cheng V., Siegel R., Effects of glossopharyngeal insufflation on cardiac function: an echocardiographic study in elite breath-hold divers, J. Appl. Physiol, 2007, 103, 823–827",{"doi":440},"10.1152\u002Fjapplphysiol.00125.2007",{"id":20,"text":442,"url":20,"identifiers":443},"Batinic T., Utz W., Breskovic T., Jordan J., Schulz-Menger J., Jankovic S., et al., Cardiac magnetic resonance imaging during pulmonary hyperinflation in apnea divers, Med. Sci. Sports Exerc., 2011, 43, 2095–2101",{"doi":444},"10.1249\u002FMSS.0b013e31821ff294",{"id":20,"text":446,"url":20,"identifiers":447},"Palada I., Bakovic D., Valic Z., Obad A., Ivancev V., Eterovic D., et al., Restoration of hemodynamics in apnea struggle phase in association with involuntary breathing movements, Respir. Physiol. Neurobiol., 2008, 161, 174–181",{"doi":448},"10.1016\u002Fj.resp.2008.01.008",{"id":20,"text":450,"url":20,"identifiers":451},"Palada I., Obad A., Bakovic D., Valic Z., Ivancev V., Dujic Z., Cerebral and peripheral hemodynamics and oxygenation during maximal dry breath-holds, Respir. Physiol. Neurobiol., 2007, 157, 374–381",{"doi":452},"10.1016\u002Fj.resp.2007.02.002",{"id":20,"text":454,"url":20,"identifiers":455},"Bakovic D., Valic Z., Eterovic D., Vukovic I., Obad A., Marinovic-Terzic I., et al., Spleen volume and blood flow response to repeated breathhold apneas, J. Appl. Physiol., 2003, 95, 1460–1466",{"doi":456},"10.1152\u002Fjapplphysiol.00221.2003",{"id":20,"text":458,"url":20,"identifiers":459},"Heusser K., Dzamonja G., Tank J., Palada I., Valic Z., Bakovic D., et al., Cardiovascular regulation during apnea in elite divers, Hypertension, 2009, 53, 719–724",{"doi":460},"10.1161\u002FHYPERTENSIONAHA.108.127530",{"id":20,"text":462,"url":20,"identifiers":463},"Joulia F., Steinberg J.G., Wolff F., Gavarry O., Jammes Y., Reduced oxidative stress and blood lactic acidosis in trained breath-hold human divers, Respir. Physiol. Neurobiol., 2002, 133, 121–130",{"doi":464},"10.1016\u002FS1569-9048(02)00133-7",{"id":20,"text":466,"url":20,"identifiers":467},"Liner M.H., Ferrigno M., Lundgren C.E., Alveolar gas exchange during simulated breath-hold diving to 20 m, Undersea Hyperb. Med., 1993, 20, 27–38",{},{"id":20,"text":469,"url":20,"identifiers":470},"Ferretti G., Extreme human breath-hold diving, Eur. J. Appl. Physiol., 2001, 84, 254–271",{"doi":471},"10.1007\u002Fs004210000377",{"id":20,"text":473,"url":20,"identifiers":474},"Fagius J., Sundlof G., The diving response in man: effects on sympathetic activity in muscle and skin nerve fascicles, J. Physiol., 1986, 377, 429–443",{"doi":475},"10.1113\u002Fjphysiol.1986.sp016196",{"id":20,"text":477,"url":20,"identifiers":478},"Kiviniemi A.M., Breskovic T., Uglesic L., Kuch B., Maslov P.Z., Sieber A., et al., Heart rate variability during static and dynamic breath-hold dives in elite divers, Auton. Neurosci., 2012, 169, 95–101",{"doi":479},"10.1016\u002Fj.autneu.2012.05.004",{"id":20,"text":481,"url":20,"identifiers":482},"Schagatay E., Andersson J.P., Hallen M., Palsson B., Selected contribution: role of spleen emptying in prolonging apneas in humans, J. Appl. Physiol., 2001, 90, 1623–1629",{"doi":483},"10.1152\u002Fjappl.2001.90.4.1623",{"id":20,"text":485,"url":20,"identifiers":486},"Palada I., Eterovic D., Obad A., Bakovic D., Valic Z., Ivancev V., et al., Spleen and cardiovascular function during short apneas in divers, J. Appl. Physiol., 2007, 103, 1958–1963",{"doi":487},"10.1152\u002Fjapplphysiol.00182.2007",{"id":20,"text":489,"url":20,"identifiers":490},"Dujic Z., Uglesic L., Breskovic T., Valic Z., Heusser K., Marinovic J., et al., Involuntary breathing movements improve cerebral oxygenation during apnea struggle phase in elite divers, J. Appl. Physiol., 2009, 107, 1840–1846",{"doi":491},"10.1152\u002Fjapplphysiol.00334.2009",{"id":20,"text":493,"url":20,"identifiers":494},"Ferrigno M., Ferretti G., Ellis A., Warkander D., Costa M., Cerretelli P., et al., Cardiovascular changes during deep breath-hold dives in a pressure chamber, J. Appl. Physiol., 1997, 83, 1282–1290",{"doi":495},"10.1152\u002Fjappl.1997.83.4.1282",{"id":20,"text":497,"url":20,"identifiers":498},"Sieber A., L’abbate A., Passera M., Garbella E., Benassi A., Bedini R., Underwater study of arterial blood pressure in breath-hold divers, J. Appl. Physiol., 2009, 107, 1526–1531",{"doi":499},"10.1152\u002Fjapplphysiol.91438.2008",{"id":20,"text":501,"url":20,"identifiers":502},"Perini R., Gheza A., Moia C., Sponsiello N., Ferretti G., Cardiovascular time courses during prolonged immersed static apnoea, Eur. J. Appl. Physiol., 2010, 110, 277–283",{"doi":503},"10.1007\u002Fs00421-010-1489-4",{"id":20,"text":505,"url":20,"identifiers":506},"Irving L., Bradycardia in Human Divers, J. Appl. Physiol., 1963, 18, 489–491",{"doi":507},"10.1152\u002Fjappl.1963.18.3.489",{"id":20,"text":509,"url":20,"identifiers":510},"Hong S.K., Song S.H., Kim P.K., Suh C.S., Seasonal observations on the cardiac rhythm during diving in the Korean ama, J. Appl. Physiol., 1967, 23, 18–22",{"doi":511},"10.1152\u002Fjappl.1967.23.1.18",{"id":20,"text":513,"url":20,"identifiers":514},"Somers V.K., Mark A.L., Zavala D.C., Abboud F.M., Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans, J. Appl. Physiol., 1989, 67, 2101–2106",{"doi":515},"10.1152\u002Fjappl.1989.67.5.2101",{"id":20,"text":517,"url":20,"identifiers":518},"Lindholm P., Lundgren C.E., Alveolar gas composition before and after maximal breath-holds in competitive divers, Undersea Hyperb. Med., 2006, 33, 463–467",{},{"id":20,"text":520,"url":20,"identifiers":521},"Overgaard K., Friis S., Pedersen R.B., Lykkeboe G., Influence of lung volume, glossopharyngeal inhalation and P(ET) O2 and P(ET) CO2 on apnea performance in trained breath-hold divers, Eur. J. Appl. Physiol., 2006, 97, 158–164",{"doi":522},"10.1007\u002Fs00421-006-0156-2",{"id":20,"text":524,"url":20,"identifiers":525},"Macefield V.G., Wallin B.G., Effects of static lung inflation on sympathetic activity in human muscle nerves at rest and during asphyxia, J. Auton. Nerv. Syst., 1995, 53, 148–156",{"doi":526},"10.1016\u002F0165-1838(94)00174-I",{"id":20,"text":528,"url":20,"identifiers":529},"Morgan B.J., Denahan T., Ebert T.J., Neurocirculatory consequences of negative intrathoracic pressure vs. asphyxia during voluntary apnea, J. Appl. Physiol., 1993, 74, 2969–2975",{"doi":530},"10.1152\u002Fjappl.1993.74.6.2969",{"id":20,"text":532,"url":20,"identifiers":533},"Breskovic T., Ivancev V., Banic I., Jordan J., Dujic Z., Peripheral chemoreflex sensitivity and sympathetic nerve activity are normal in apnea divers during training season, Auton. Neurosci., 2010, 154, 42–47",{"doi":534},"10.1016\u002Fj.autneu.2009.11.001",{"id":20,"text":536,"url":20,"identifiers":537},"Breskovic T., Valic Z., Lipp A., Heusser K., Ivancev V., Tank J., et al., Peripheral chemoreflex regulation of sympathetic vasomotor tone in apnea divers, Clin. Auton. Res., 2010, 20, 57–63",{"doi":538},"10.1007\u002Fs10286-009-0034-1",{"id":20,"text":540,"url":20,"identifiers":541},"Breskovic T., Steinback C.D., Salmanpour A., Shoemaker J.K., Dujic Z., Recruitment pattern of sympathetic neurons during breath-holding at different lung volumes in apnea divers and controls, Auton. Neurosci., 2011, 164, 74–81",{"doi":542},"10.1016\u002Fj.autneu.2011.05.003",{"id":20,"text":544,"url":20,"identifiers":545},"Steinback C.D., Breskovic T., Banic I., Dujic Z., Shoemaker J.K., Autonomic and cardiovascular responses to chemoreflex stress in apnoea divers, Auton. Neurosci., 2010, 156, 138–143",{"doi":546},"10.1016\u002Fj.autneu.2010.05.002",{"id":20,"text":548,"url":20,"identifiers":549},"Dujic Z., Ivancev V., Heusser K., Dzamonja G., Palada I., Valic Z., et al., Central chemoreflex sensitivity and sympathetic neural outflow in elite breath-hold divers, J. Appl. Physiol., 2008, 104, 205–211",{"doi":550},"10.1152\u002Fjapplphysiol.00844.2007",{"id":20,"text":552,"url":20,"identifiers":553},"Macefield V.G., Wallin B.G., Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity, J. Physiol., 1999, 516, 293–301",{"doi":554},"10.1111\u002Fj.1469-7793.1999.293aa.x",{"id":20,"text":556,"url":20,"identifiers":557},"Elam M., Sverrisdottir Y.B., Rundqvist B., McKenzie D., Wallin B.G., Macefield V.G., Pathological sympathoexcitation: how is it achieved?, Acta Physiol. Scand., 2003, 177, 405–411",{"doi":558},"10.1046\u002Fj.1365-201X.2003.01080.x",{"id":20,"text":560,"url":20,"identifiers":561},"Salmanpour A., Brown L.J., Shoemaker J.K., Spike detection in human muscle sympathetic nerve activity using a matched wavelet approach, J. Neurosci. Methods, 2010, 193, 343–355",{"doi":562},"10.1016\u002Fj.jneumeth.2010.08.035",{"id":20,"text":564,"url":20,"identifiers":565},"Steinback C.D., Salmanpour A., Breskovic T., Dujic Z., Shoemaker J.K., Sympathetic neural activation: an ordered affair, J. Physiol., 2010, 588, 4825–4836",{"doi":566},"10.1113\u002Fjphysiol.2010.195941",{"id":20,"text":568,"url":20,"identifiers":569},"Henneman E., Somjen G., Carpenter D.O., Functional siginifcance of cell size in spinal motoneurons, J. Neurophysiol., 1965, 28, 560–580",{"doi":570},"10.1152\u002Fjn.1965.28.3.560",{"id":20,"text":572,"url":20,"identifiers":573},"Salmanpour A., Brown L.J., Steinback C.D., Usselman C.W., Goswami R., Shoemaker J.K., Relationship between size and latency of action potentials in human muscle sympathetic nerve activity, J. Neurophysiol., 2011, 105, 2830–2842",{"doi":574},"10.1152\u002Fjn.00814.2010",{"id":20,"text":576,"url":20,"identifiers":577},"Pan A.W., He J., Kinouchi Y., Yamaguchi H., Miyamoto H., Blood flow in the carotid artery during breath-holding in relation to diving bradycardia, Eur. J. Appl. Physiol. Occup. Physiol., 1997, 75, 388–395",{"doi":578},"10.1007\u002Fs004210050177",{"id":20,"text":580,"url":20,"identifiers":581},"Przybylowski T., Bangash M.F., Reichmuth K., Morgan B.J., Skatrud J.B., Dempsey J.A., Mechanisms of the cerebrovascular response to apnoea in humans, J. Physiol., 2003, 548, 323–332",{"doi":582},"10.1111\u002Fj.1469-7793.2003.t01-1-00323.x",{"id":20,"text":584,"url":20,"identifiers":585},"Vantanajal J.S., Ashmead J.C., Anderson T.J., Hepple R.T., Poulin M.J., Differential sensitivities of cerebral and brachial blood flow to hypercapnia in humans, J. Appl. Physiol., 2007, 102, 87–93",{"doi":586},"10.1152\u002Fjapplphysiol.00772.2006",{"id":20,"text":588,"url":20,"identifiers":589},"Ainslie P.N., Barach A., Murrell C., Hamlin M., Hellemans J., Ogoh S., Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise, Am. J. Physiol. Heart Circ. Physiol., 2007, 292, H976–H983",{"doi":590},"10.1152\u002Fajpheart.00639.2006",{"id":20,"text":592,"url":20,"identifiers":593},"Andersson J.P., Liner M.H., Jonsson H., Increased serum levels of the brain damage marker S100B after apnea in trained breath-hold divers: a study including respiratory and cardiovascular observations, J. Appl. Physiol., 2009, 107, 809–815",{"doi":594},"10.1152\u002Fjapplphysiol.91434.2008",{"id":20,"text":596,"url":20,"identifiers":597},"Riuzzi F., Sorci G., Beccafico S., Donato R., S100B engages RAGE or bFGF\u002FFGFR1 in myoblasts depending on its own concentration and myoblast density. Implications for muscle regeneration, PLoS One, 2012, 7, e28700",{"doi":598},"10.1371\u002Fjournal.pone.0028700",{"id":20,"text":600,"url":20,"identifiers":601},"Kohshi K., Katoh T., Abe H., Okudera T., Neurological accidents caused by repetitive breath-hold dives: two case reports, J. Neurol. Sci., 2000, 178, 66–69",{"doi":602},"10.1016\u002FS0022-510X(00)00360-9",{"id":20,"text":604,"url":20,"identifiers":605},"Potkin R., Uszler J.M., Brain function imaging in asymptomatic elite breath-hold divers, In: Lindholm P., Pollock N.W., Lundgren C.E., eds., Breath-hold diving. Proceedings of the Undersea and Hyperbaric Medical Society\u002FDivers Alert Network, June 20–21 Workshop, NC: Divers Alert Network, Durham, 2006, 135–137",{},{"id":20,"text":607,"url":20,"identifiers":608},"Lin Y.C., Breath-hold diving in terrestrial mammals, Exerc. Sport Sci. Rev., 1982, 10, 270–307",{},{"id":20,"text":610,"url":20,"identifiers":611},"Dejours P., Hazards of hypoxia during diving, In: Rahn H., ed., Physiology of breath-hold diving and the Ama of Japan papers, National Academy of Sciences — National Research Council, Washington, 1965, 183–193",{},{"id":20,"text":613,"url":20,"identifiers":614},"Cross T.J., Breskovic T., Sabapathy S., Zubin M.P., Johnson B.D., Dujic Z., Respiratory muscle pressure development during breath holding in apnea divers, Med. Sci. Sports Exerc., 2013, 45, 93–101",{"doi":615},"10.1249\u002FMSS.0b013e3182690e6a",{"id":20,"text":617,"url":20,"identifiers":618},"Breskovic T., Lojpur M., Maslov P.Z., Cross T.J., Kraljevic J., Ljubkovic M., et al., The influence of varying inspired fractions of O(2) and CO(2) on the development of involuntary breathing movements during maximal apnoea, Respir. Physiol. Neurobiol., 2012, 181, 228–233",{"doi":619},"10.1016\u002Fj.resp.2012.03.007",{"id":20,"text":621,"url":20,"identifiers":622},"Cross T.J., Kavanagh J.J., Breskovic T., Zubin M.P., Lojpur M., Johnson B.D., et al., The effects of involuntary respiratory contractions on cerebral blood flow during maximal apnoea in trained divers, PLoS One, 2013, 8, e66950",{"doi":623},"10.1371\u002Fjournal.pone.0066950",{"id":20,"text":625,"url":20,"identifiers":626},"Dzamonja G., Tank J., Heusser K., Palada I., Valic Z., Bakovic D., et al., Glossopharyngeal insufflation induces cardioinhibitory syncope in apnea divers, Clin. Auton. Res., 2010, 20, 381–384",{"doi":627},"10.1007\u002Fs10286-010-0075-5",{"id":20,"text":629,"url":20,"identifiers":630},"Hurford W.E., Hochachka P.W., Schneider R.C., Guyton G.P., Stanek K.S., Zapol D.G., et al., Splenic contraction, catecholamine release, and blood volume redistribution during diving in the Weddell seal, J. Appl. Physiol., 1996, 80, 298–306",{"doi":631},"10.1152\u002Fjappl.1996.80.1.298",{"id":20,"text":633,"url":20,"identifiers":634},"Laub M., Hvid-Jacobsen K., Hovind P., Kanstrup I.L., Christensen N.J., Nielsen S.L., Spleen emptying and venous hematocrit in humans during exercise, J. Appl. Physiol., 1993, 74, 1024–1026",{"doi":635},"10.1152\u002Fjappl.1993.74.3.1024",{"id":20,"text":637,"url":20,"identifiers":638},"Bakovic D., Eterovic D., Saratlija-Novakovic Z., Palada I., Valic Z., Bilopavlovic N., et al., Effect of human splenic contraction on variation in circulating blood cell counts, Clin. Exp. Pharmacol. Physiol., 2005, 32, 944–951",{"doi":639},"10.1111\u002Fj.1440-1681.2005.04289.x",{"id":20,"text":641,"url":20,"identifiers":642},"Aster R.H., Pooling of platelets in the spleen: role in the pathogenesis of “hypersplenic” thrombocytopenia, J. Clin. Invest., 1966, 45, 645–657",{"doi":643},"10.1172\u002FJCI105380",{"id":20,"text":645,"url":20,"identifiers":646},"Branehog I., Weinfeld A., Roos B., The exchangeable splenic platelet pool studied with epinephrine infusion in idiopathic thrombocytopenic purpura and in patients with splenomegaly, Br. J. Haematol., 1973, 25, 239–248",{"doi":647},"10.1111\u002Fj.1365-2141.1973.tb01735.x",{"id":20,"text":649,"url":20,"identifiers":650},"Schmidt K.G., Rasmussen J.W., Are young platelets released in excess from the spleen in response to short-term physical exercise?, Scand. J. Haematol., 1984, 32, 207–214",{"doi":651},"10.1111\u002Fj.1600-0609.1984.tb02179.x",{"id":20,"text":653,"url":20,"identifiers":654},"Chamberlain K.G., Tong M., Penington D.G., Properties of the exchangeable splenic platelets released into the circulation during exercise-induced thrombocytosis, Am. J. Hematol., 1990, 34, 161–168",{"doi":655},"10.1002\u002Fajh.2830340302",{"id":20,"text":657,"url":20,"identifiers":658},"van der Loo B., Martin J.F., A role for changes in platelet production in the cause of acute coronary syndromes, Arterioscler. Thromb. Vasc. Biol., 1999, 19, 672–679",{"doi":659},"10.1161\u002F01.ATV.19.3.672",{"id":20,"text":661,"url":20,"identifiers":662},"Ojiri Y., Noguchi K., Shiroma N., Matsuzaki T., Sakanashi M., Sakanashi M., Uneven changes in circulating blood cell counts with adrenergic stimulation to the canine spleen, Clin. Exp. Pharmacol. Physiol., 2002, 29, 53–59",{"doi":663},"10.1046\u002Fj.1440-1681.2002.03598.x",{"id":20,"text":665,"url":20,"identifiers":666},"Kjeldsen S.E., Weder A.B., Egan B., Neubig R., Zweifler A.J., Julius S., Effect of circulating epinephrine on platelet function and hematocrit, Hypertension, 1995, 25, 1096–1105",{"doi":667},"10.1161\u002F01.HYP.25.5.1096",{"id":20,"text":669,"url":20,"identifiers":670},"Sloand J.A., Hooper M., Izzo J.L. Jr., Effects of circulating norepinephrine on platelet, leukocyte and red blood cell counts by alpha 1-adrenergic stimulation, Am. J. Cardiol., 1989, 63, 1140–1142",{"doi":671},"10.1016\u002F0002-9149(89)90096-9",{"id":20,"text":673,"url":20,"identifiers":674},"Wadenvik H., Kutti J., The effect of an adrenaline infusion on the splenic blood flow and intrasplenic platelet kinetics, Br. J. Haematol., 1987, 67, 187–192",{"doi":675},"10.1111\u002Fj.1365-2141.1987.tb02325.x",{"id":20,"text":677,"url":20,"identifiers":678},"Bakovic D., Eterovic D., Palada I., Valic Z., Dujic Z., Does breath-holding increase the risk of a thrombotic event?, Platelets, 2008, 19, 314–315",{"doi":679},"10.1080\u002F09537100801910846",{"id":20,"text":681,"url":20,"identifiers":682},"Butterworth R.J., Bath P.M., The relationship between mean platelet volume, stroke subtype and clinical outcome, Platelets, 1998, 9, 359–364",{"doi":683},"10.1080\u002F09537109876429",{"id":20,"text":685,"url":20,"identifiers":686},"Khandekar M.M., Khurana A.S., Deshmukh S.D., Kakrani A.L., Katdare A.D., Inamdar A.K., Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario, J. Clin. Pathol., 2006, 59, 146–149",{"doi":687},"10.1136\u002Fjcp.2004.025387",{"id":20,"text":689,"url":20,"identifiers":690},"Greisenegger S., Endler G., Hsieh K., Tentschert S., Mannhalter C., Lalouschek W., Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?, Stroke, 2004, 35, 1688–1691",{"doi":691},"10.1161\u002F01.STR.0000130512.81212.a2",{"id":20,"text":693,"url":20,"identifiers":694},"Bakovic D., Pivac N., Eterovic D., Breskovic T., Zubin P., Obad A., et al., The effects of low-dose epinephrine infusion on spleen size, central and hepatic circulation and circulating platelets, Clin. Physiol. Funct. Imaging, 2013, 33, 30–37",{},{"id":20,"text":696,"url":20,"identifiers":697},"Varol E., Ozturk O., Gonca T., Has M., Ozaydin M., Erdogan D., et al., Mean platelet volume is increased in patients with severe obstructive sleep apnea, Scand. J. Clin. Lab. Invest., 2010, 70, 497–502",{"doi":698},"10.3109\u002F00365513.2010.520733",{"id":20,"text":700,"url":20,"identifiers":701},"Parish J.M., Somers V.K., Obstructive sleep apnea and cardiovascular disease, Mayo Clin. Proc., 2004, 79, 1036–1046",{"doi":702},"10.4065\u002F79.8.1036",{"id":20,"text":704,"url":20,"identifiers":705},"Kohli P., Balachandran J.S., Malhotra A., Obstructive sleep apnea and the risk for cardiovascular disease, Curr. Atheroscler. Rep., 2011, 13, 138–146",{"doi":706},"10.1007\u002Fs11883-011-0161-8",{"id":20,"text":708,"url":20,"identifiers":709},"Waradekar N.V., Sinoway L.I., Zwillich C.W., Leuenberger U.A., Influence of treatment on muscle sympathetic nerve activity in sleep apnea, Am. J. Respir. Crit. Care Med., 1996, 153, 1333–1338",{"doi":710},"10.1164\u002Fajrccm.153.4.8616563",{"id":20,"text":712,"url":20,"identifiers":713},"Sahota P., Vahidy F., Nguyen C., Bui T.T., Yang B., Parsha K., et al., Changes in spleen size in patients with acute ischemic stroke: a pilot observational study, Int. J. Stroke, 2013, 8, 60–67",{"doi":714},"10.1111\u002Fijs.12022",{"id":20,"text":716,"url":20,"identifiers":717},"Dujic Z., Breskovic T., Ljubkovic M., Breath hold diving: in vivo model of the brain survival response in man?, Med. Hypotheses, 2011, 76, 737–740",{"doi":718},"10.1016\u002Fj.mehy.2011.02.012",{"id":720,"createTime":721,"updateTime":722,"relativeEntities":723,"slug":724,"properties":725,"entityType":125,"verifyStatus":126,"verifyTime":722,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":734,"fullTextUrl":20,"authors":735,"publicationType":219,"publisherRelationship":892,"citationCount":20,"citationInfo":20,"publishDate":940,"publishYear":395,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":941,"openAccess":20,"references":20,"isForceReanalyzing":271},"452396bf-ff6a-4df5-b373-a9ae49c718c9","2024-01-08T16:06:53.309+00:00","2025-02-23T23:28:38.105+00:00",[],"Region-specific-neuron-and-synapse-loss-in-the-hippocampus-of-APPSL-PS1-knock-in-mice",{"abstract":726,"title":728,"references":730,"doi":732},{"EN":727},"Transgenic mouse models with knock-in (KI) expression of human mutant amyloid precursor protein (APP) and\u002For human presenilin 1 (PS1) may be helpful to elucidate the cellular consequences of APP and PS1 misprocessing in the aging brain. Age-related alterations in total numbers of neurons and in numbers of synaptophysin-immunoreactive presynaptic boutons (SIPB), as well as the amyloid plaque load were analyzed in the hippocampal dentate gyrus (DG), CA3, and CA1-2 of 2- and 10-month-old APPSL\u002FPS1 homozygous KI, APPSL (expressing human mutant APP751 carrying the Swedish [K670N\u002FM671L] and London [V717I] mutations under Thy-1 promoter), and PS1 homozygous KI mice (expressing human PS1 mutations [M233T and L235P]). APPSL\u002FPS1 homozygous KI mice, but neither APPSL mice nor PS1 homozygous KI mice, showed substantial agerelated loss of neurons (−47.2%) and SIPB (−22.6%), specifically in CA1-2. PS1 homozygous KI mice showed an age-related increase in hippocampal granule cell numbers (+37.9%). Loss of neurons and SIPB greatly exceeded the amount of local extracellular Aβ aggregation and astrocytes, whereas region-specific accumulation of intraneuronal Aβ preceded neuron and synapse loss. An age-related increase in the ratio of SIPB to neuron numbers in CA1-2 of APPSL\u002FPS1 homozygous KI mice was suggestive of compensatory synaptic plasticity. These findings indicate a region-selectivity in intra- and extraneuronal Aβ accumulation in connection with neuron and synapse loss in the hippocampus of APPSL\u002FPS1 homozygous KI mice.",{"EN":729},"Region-specific neuron and synapse loss in the hippocampus of APPSL\u002FPS1 knock-in mice",{"VOID":731},"Scheff S.W., Price D.A., Schmitt F.A., Scheff M.A., Mufson E.J., Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer’s disease, J. Alzheimers Dis., 2011, 24, 547–557\nSelkoe D.J., Alzheimer’s disease is a synaptic failure, Science, 2002, 298, 789–791\nWalsh D.M., Selkoe D.J., Deciphering the molecular basis of memory failure in Alzheimer’s disease, Neuron, 2004, 44, 181–193\nYu W., Lu B., Synapses and dendritic spines as pathogenic targets in Alzheimer’s disease, Neural Plast., 2012, 2012, 1–8\nTam J.H., Pasternak S.H., Amyloid and Alzheimer’s disease: inside and out, Can. J. Neurol. Sci., 2012, 39, 286–298\nLuque F.A., Jaffe S.L., The molecular and cellular pathogenesis of dementia of the Alzheimer’s type an overview, Int. Rev. Neurobiol., 2009, 84, 151–165\nFjell A.M., Walhovd K.B., Neuroimaging results impose new views on Alzheimer’s disease-the role of amyloid revised, Mol. Neurobiol., 2012, 1–20\nHardy J., Selkoe D.J., The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics, Science, 2002, 297, 353–356\nMucke L., Masliah E., Yu G.Q., Mallory M., Rockenstein E.M., Tatsuno G., et al., High-level neuronal expression of abeta 1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation, J. Neurosci., 2000, 20, 4050–4058\nKlein W.L., Krafft G.A., Finch C.E., Targeting small Abeta oligomers: the solution to an Alzheimer’s disease conundrum?, Trends Neurosci., 2001, 24, 219–224\nSchmitz C., Rutten B.P., Pielen A., Schafer S., Wirths O., Tremp G., et al., Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer’s disease, Am. J. Pathol., 2004, 164, 1495–1502\nBoncristiano S., Calhoun M.E., Howard V., Bondolfi L., Kaeser S.A., Wiederhold K.H., et al., Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice, Neurobiol. Aging, 2005, 26, 607–613\nDickey C.A., Loring J.F., Montgomery J., Gordon M.N., Eastman P.S., Morgan D., Selectively reduced expression of synaptic plasticityrelated genes in amyloid precursor protein + presenilin-1 transgenic mice, J. Neurosci., 2003, 23, 5219–5226\nHsia A.Y., Masliah E., McConlogue L., Yu G.Q., Tatsuno G., Hu K., et al., Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models, Proc. Natl. Acad. Sci. USA, 1999, 96, 3228–3233\nRutten B.P., Van der Kolk N.M., Schafer S., van Zandvoort M.A., Bayer T.A., Steinbusch H.W., et al., Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL\u002FPS1M146L transgenic mice, Am. J. Pathol., 2005, 167, 161–173\nWest M.J., Bach G., Soderman A., Jensen J.L., Synaptic contact number and size in stratum radiatum CA1 of APP\u002FPS1DeltaE9 transgenic mice, Neurobiol. Aging, 2009, 30, 1756–1776\nNizzari M., Thellung S., Corsaro A., Villa V., Pagano A., Porcile C., et al., Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling, J. Toxicol., 2012, 2012, 1–13\nRevett T.J., Baker G.B., Jhamandas J., Kar S., Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology, J. Psychiatry Neurosci., 2013, 38, 6–23\nCasas C., Sergeant N., Itier J.M., Blanchard V., Wirths O., van der Kolk N., et al., Massive CA1\u002F2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model, Am. J. Pathol., 2004, 165, 1289–1300\nWirths O., Breyhan H., Schafer S., Roth C., Bayer T.A., Deficits in working memory and motor performance in the APP\u002FPS1ki mouse model for Alzheimer’s disease, Neurobiol. Aging, 2008, 29, 891–901\nWirths O., Weis J., Szczygielski J., Multhaup G., Bayer T.A., Axonopathy in an APP\u002FPS1 transgenic mouse model of Alzheimer’s disease, Acta Neuropathol., 2006, 111, 312–319\nTakahashi H., Brasnjevic I., Rutten B.P., Van Der Kolk N., Perl D.P., Bouras C., et al., Hippocampal interneuron loss in an APP\u002FPS1 double mutant mouse and in Alzheimer’s disease, Brain Struct. Funct., 2010, 214, 145–160\nBorchardt T., Camakaris J., Cappai R., Masters C.L., Beyreuther K., Multhaup G., Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursorprotein secretion, Biochem. J., 1999, 344, 461–467\nSchmitz C., Hof P.R., Design-based stereology in neuroscience, Neuroscience, 2005, 130, 813–831\nFranklin K., Paxinos G., The mouse brain in stereotaxic coordinates, Academic Press, San Diego, 1997\nVan de Berg W.D., Blokland A., Cuello A.C., Schmitz C., Vreuls W., Steinbusch H.W., et al., Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex-a stereological and behavioral analysis, J. Chem. Neuroanat., 2000, 20, 71–82\nHeinonen O., Soininen H., Sorvari H., Kosunen O. Paljarvi L., Koivisto E., et al., Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer’s disease, Neuroscience, 1995, 64, 375–385\nTerry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., et al., Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment, Ann. Neurol, 1991, 30, 572–580\nIngelsson M., Fukumoto H., Newell K.L., Growdon J.H., Hedley-Whyte E.T., Frosch M.P., et al., Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain, Neurology, 2004, 62, 925–931\nClare R., King V.G., Wirenfeldt M., Vinters H.V., 2010, Synapse loss in dementias, J. Neurosci. Res., 88, 2083–2090\nCotel M.C., Bayer T.A., Wirths O., Age-dependent loss of dentate gyrus granule cells in APP\u002FPS1KI mice, Brain Res., 2008, 1222, 207–213\nBreyhan H., Wirths O., Duan K., Marcello A., Rettig J., Bayer T.A., APP\u002FPS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy, Acta Neuropathol., 2009, 117, 677–685\nTomiyama T., Matsuyama S., Iso H., Umeda T., Takuma H., Ohnishi K., et al., A mouse model of amyloid β oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo, J. Neurosci., 2010, 30, 4845–4856\nSanchez-Varo R., Trujillo-Estrada L., Sanchez-Mejias E., Torres M., Baglietto-Vargas D., Moreno-Gonzalez I., et al., Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus, Acta Neuropathol., 2012, 1–18\nIrizarry M.C., Soriano F., McNamara M., Page K.J., Schenk D., Games D., et al., Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse, J. Neurosci., 1997, 17, 7053–7059\nCalhoun M.E., Wiederhold K.H., Abramowski D., Phinney A.L., Probst A., Sturchler-Pierrat C., et al., Neuron loss in APP transgenic mice, Nature, 1998, 395, 755–756\nTakeuchi A., Irizarry M.C., Duff K., Saido T.C., Hsiao Ashe K., Hasegawa M., et al., Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss, Am. J. Pathol., 2000, 157, 331–339\nDickson D.W., Building a more perfect beast: APP transgenic mice with neuronal loss, Am. J. Pathol., 2004, 164, 1143–1146\nHowlett D.R., Bowler K., Soden P.E., Riddell D., Davis J.B., Richardson J.C., et al., Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer’s disease, Histol. Histopathol., 2008, 23, 67–76\nVan Broeck B., Vanhoutte G., Pirici D., Van Dam D., Wils H., Cuijt I., et al., Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer’s disease, Neurobiol. Aging, 2008, 29, 241–252\nElder G.A., Gama Sosa M.A., De Gasperi R., Dickstein D.L., Hof P.R., Presenilin transgenic mice as models of Alzheimer’s disease, Brain Struct. Funct., 2010, 214, 127–143\nMukaetova-Ladinska E.B., Garcia-Siera F., Hurt J., Gertz H.J., Xuereb J.H., Hills R., et al., Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer’s disease, Am. J. Pathol., 2000, 157, 623–636\nCounts S.E., Nadeem M., Lad S.P., Wuu J., Mufson E.J., Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment, J. Neuropathol. Exp. Neurol., 2006, 65, 592–601\nBell K.F., Bennett D.A., Cuello A.C., Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment, J. Neurosci., 2007, 27, 10810–10817\nAkram A., Christoffel D., Rocher A.B., Bouras C., Kovari E., Perl D.P., et al., Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer’s disease, Neurobiol. Aging, 2008, 29, 1296–1307\nBronfman F.C., Moechars D., Van Leuven F., Acetylcholinesterasepositive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice, Neurobiol. Dis., 2000, 7, 152–168\nBriones T.L., Suh E., Jozsa L., Rogozinska M., Woods J., Wadowska M., Changes in number of synapses and mitochondria in presynaptic terminals in the dentate gyrus following cerebral ischemia and rehabilitation training, Brain Res., 2005, 1033, 51–57\nDeKosky S.T., Scheff S.W., Styren S.D., Structural correlates of cognition in dementia: quantification and assessment of synapse change, Neurodegeneration, 1996, 5, 417–421\nSeeger G., Gärtner U., Ueberham U., Rohn S., Arendt T., FAD-mutation of APP is associated with a loss of its synaptotrophic activity, Neurobiol. Dis., 2009, 35, 258–263\nDong H., Martin M.V., Chambers S., Csernansky J.G., Spatial relationship between synapse loss and β-amyloid deposition in Tg2576 mice, J. Comp. Neurol., 2006, 500, 311–321\nHu L., Wong T.P., Cote S.L., Bell K.F., Cuello A.C., The impact of Abetaplaques on cortical cholinergic and non-cholinergic presynaptic boutons in alzheimer’s disease-like transgenic mice, Neuroscience, 2003, 121, 421–432\nSavage M.J., Lin Y.G., Ciallella J.R., Flood D.G., Scott R.W., Activation of c-Jun N-terminal kinase and p38 in an Alzheimer’s disease model is associated with amyloid deposition, J. Neurosci., 2002, 22, 3376–3385\nGruart A., Lopez-Ramos J.C., Munoz M.D., Delgado-Garcia J.M., Aged wild-type and APP, PS1, and APP + PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load, Neurobiol. Dis., 2008, 30, 439–450\nKoo E.H., Kopan R., Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration, Nat. Med., 2004, Suppl. 10, S26–33\nMorfini G., Pigino G., Beffert U., Busciglio J., Brady S.T., Fast axonal transport misregulation and Alzheimer’s disease, Neuromolecular Med., 2002, 2, 89–99\nGadadhar A., Marr R., Lazarov O., Presenilin-1 regulates neural progenitor cell differentiation in the adult brain, J. Neurosci., 2011, 31, 2615–2623\nLemmens M.A.M., Sierksma A.S.R., Rutten B.P.F., Dennissen F., Steinbusch H.W.M., Lucassen P.J., et al., Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease, Brain Struct. Funct., 2011, 216, 227–237\nvan Tijn P., Kamphuis W., Marlatt M.W., Hol E.M., Lucassen P.J., Presenilin mouse and zebrafish models for dementia: focus on neurogenesis, Prog. Neurobiol., 2011, 93, 149–164",{"VOID":733},"10.2478\u002Fs13380-013-0111-8","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-013-0111-8\u002Fhtml",[736,760,773,788,808,824,839,852,872],{"id":737,"sortIndex":21,"researcher":20,"roles":738,"affiliations":739,"properties":757,"displayName":759,"givenName":20,"familyName":20},"d393ae0a-859e-4757-8462-9a0999821958",[133],[740,748],{"id":741,"sortIndex":21,"affiliation":742,"properties":20},"4f0e5f34-4b26-470b-b044-1a984054116b",{"id":741,"createTime":20,"updateTime":20,"relativeEntities":743,"slug":20,"properties":744,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":747,"statistic":20},[],{"title":745},{"VI":746},"Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands",[],{"id":749,"sortIndex":104,"affiliation":750,"properties":756},"0b45f975-4c94-4cc5-9f4d-325334213f1d",{"id":749,"createTime":20,"updateTime":20,"relativeEntities":751,"slug":20,"properties":752,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":755,"statistic":20},[],{"title":753},{"VI":754},"European Graduate School of Neuroscience (EURON), Maastricht, The Netherlands",[],{},{"title":758},{"VI":759},"Ivona Brasnjevic",{"id":761,"sortIndex":104,"researcher":20,"roles":762,"affiliations":763,"properties":770,"displayName":772,"givenName":20,"familyName":20},"0558a2a8-b5e5-4b26-9fb6-bfc6ad6c8a77",[133],[764],{"id":741,"sortIndex":21,"affiliation":765,"properties":20},{"id":741,"createTime":20,"updateTime":20,"relativeEntities":766,"slug":20,"properties":767,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":769,"statistic":20},[],{"title":768},{"VI":746},[],{"title":771},{"VI":772},"Roy Lardenoije",{"id":774,"sortIndex":174,"researcher":20,"roles":775,"affiliations":776,"properties":785,"displayName":787,"givenName":20,"familyName":20},"b08b6e7e-6afb-4531-81cb-439387f02ebe",[133],[777],{"id":778,"sortIndex":21,"affiliation":779,"properties":20},"0a361890-dc3c-4575-9290-c132f466e8eb",{"id":778,"createTime":20,"updateTime":20,"relativeEntities":780,"slug":20,"properties":781,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":784,"statistic":20},[],{"title":782},{"VI":783},"Department of Anatomy II, Institute of Anatomy, Ludwig-Maximilians-University, Munich, Germany",[],{"title":786},{"VI":787},"Christoph Schmitz",{"id":789,"sortIndex":200,"researcher":20,"roles":790,"affiliations":791,"properties":805,"displayName":807,"givenName":20,"familyName":20},"93226007-a61d-497b-8407-b20e4d7a99ec",[133],[792,798],{"id":741,"sortIndex":21,"affiliation":793,"properties":20},{"id":741,"createTime":20,"updateTime":20,"relativeEntities":794,"slug":20,"properties":795,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":797,"statistic":20},[],{"title":796},{"VI":746},[],{"id":749,"sortIndex":104,"affiliation":799,"properties":804},{"id":749,"createTime":20,"updateTime":20,"relativeEntities":800,"slug":20,"properties":801,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":803,"statistic":20},[],{"title":802},{"VI":754},[],{},{"title":806},{"VI":807},"Nicolien Van Der Kolk",{"id":809,"sortIndex":810,"researcher":20,"roles":811,"affiliations":812,"properties":821,"displayName":823,"givenName":20,"familyName":20},"ec6a7413-054e-4b3b-8530-009af8f3789c",4,[133],[813],{"id":814,"sortIndex":21,"affiliation":815,"properties":20},"67a905f3-8d77-44dc-a4f6-a44db22e2983",{"id":814,"createTime":20,"updateTime":20,"relativeEntities":816,"slug":20,"properties":817,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":820,"statistic":20},[],{"title":818},{"VI":819},"Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA",[],{"title":822},{"VI":823},"Dara L. Dickstein",{"id":825,"sortIndex":397,"researcher":20,"roles":826,"affiliations":827,"properties":836,"displayName":838,"givenName":20,"familyName":20},"90202785-3816-4fb1-9c9d-d4935a8ff2b6",[133],[828],{"id":829,"sortIndex":21,"affiliation":830,"properties":20},"e6503a9b-febd-4d29-b746-81622dc13fbf",{"id":829,"createTime":20,"updateTime":20,"relativeEntities":831,"slug":20,"properties":832,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":835,"statistic":20},[],{"title":833},{"VI":834},"Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Ehime, Japan",[],{"title":837},{"VI":838},"Hisaaki Takahashi",{"id":840,"sortIndex":86,"researcher":20,"roles":841,"affiliations":842,"properties":849,"displayName":851,"givenName":20,"familyName":20},"7c4f0b5c-433e-43c0-86a9-bb00b14767d5",[133],[843],{"id":814,"sortIndex":21,"affiliation":844,"properties":20},{"id":814,"createTime":20,"updateTime":20,"relativeEntities":845,"slug":20,"properties":846,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":848,"statistic":20},[],{"title":847},{"VI":819},[],{"title":850},{"VI":851},"Patrick R. Hof",{"id":853,"sortIndex":105,"researcher":20,"roles":854,"affiliations":855,"properties":869,"displayName":871,"givenName":20,"familyName":20},"18bdfc59-5cad-4177-b1e7-23a081106d66",[133],[856,862],{"id":741,"sortIndex":21,"affiliation":857,"properties":20},{"id":741,"createTime":20,"updateTime":20,"relativeEntities":858,"slug":20,"properties":859,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":861,"statistic":20},[],{"title":860},{"VI":746},[],{"id":749,"sortIndex":104,"affiliation":863,"properties":868},{"id":749,"createTime":20,"updateTime":20,"relativeEntities":864,"slug":20,"properties":865,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":867,"statistic":20},[],{"title":866},{"VI":754},[],{},{"title":870},{"VI":871},"Harry W. M. Steinbusch",{"id":873,"sortIndex":393,"researcher":20,"roles":874,"affiliations":875,"properties":889,"displayName":891,"givenName":20,"familyName":20},"9d8adef2-4d89-46d6-a998-26b19da12881",[133],[876,882],{"id":741,"sortIndex":21,"affiliation":877,"properties":20},{"id":741,"createTime":20,"updateTime":20,"relativeEntities":878,"slug":20,"properties":879,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":881,"statistic":20},[],{"title":880},{"VI":746},[],{"id":749,"sortIndex":104,"affiliation":883,"properties":888},{"id":749,"createTime":20,"updateTime":20,"relativeEntities":884,"slug":20,"properties":885,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":887,"statistic":20},[],{"title":886},{"VI":754},[],{},{"title":890},{"VI":891},"Bart P. F. Rutten",{"url":734,"publisher":893,"properties":935},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":894,"slug":10,"properties":895,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":899,"manageAffiliations":904,"indexDatabases":915,"url":20,"thumbnailPath":20,"statistic":930,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":896,"title":897,"eissn":898},{"VOID":13},{"EN":15},{"VOID":17},[900],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":901,"label":902,"description":903,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[905,910],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":906,"slug":20,"properties":907,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":909,"statistic":20},[],{"title":908},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":911,"slug":20,"properties":912,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":914,"statistic":20},[],{"title":913},{"EN":42},[],[916,923],{"id":46,"indexDatabase":917,"url":57,"indexYears":58,"academicFieldIds":922,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":918,"label":919,"description":920,"key":54,"publicationTags":921,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":924,"url":76,"indexYears":20,"academicFieldIds":929,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":925,"label":926,"description":927,"key":72,"publicationTags":928,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":931,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":932,"totalCitation":93,"totalCitationByYear":933,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":934,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":936,"volume":938},{"VOID":937},"8-19",{"VOID":939},"4","2013-03-07",[61,74],{"id":943,"createTime":944,"updateTime":945,"relativeEntities":946,"slug":947,"properties":948,"entityType":125,"verifyStatus":126,"verifyTime":945,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":957,"fullTextUrl":20,"authors":958,"publicationType":219,"publisherRelationship":1121,"citationCount":20,"citationInfo":20,"publishDate":1169,"publishYear":1170,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1171,"openAccess":20,"references":20,"isForceReanalyzing":271},"3eea1437-9093-478f-b36d-68e4205509ed","2023-12-04T11:32:04.904+00:00","2025-02-23T20:01:29.910+00:00",[],"Diffuse-disconnectivity-in-traumatic-brain-injury-a-resting-state-fMRI-and-DTI-study",{"abstract":949,"title":951,"references":953,"doi":955},{"EN":950},"Diffuse axonal injury is a common pathological consequence of Traumatic Brain Injury (TBI). Diffusion Tensor Imaging is an ideal technique to study white matter integrity using the Fractional Anisotropy (FA) index which is a measure of axonal integrity and coherence. There have been several reports showing reduced FA in individuals with TBI, which suggest demyelination or reduced fiber density in white matter tracts secondary to injury. Individuals with TBI are usually diagnosed with cognitive deficits such as reduced attention span, memory and executive function. In this study we sought to investigate correlations between brain functional networks, white matter integrity, and TBI severity in individuals with TBI ranging from mild to severe. A resting state functional magnetic resonance imaging protocol was used to study the default mode network in subjects at rest. FA values were decreased throughout all white matter tracts in the mild to severe TBI subjects. FA values were also negatively correlated with TBI injury severity ratings. The default mode network showed several brain regions in which connectivity measures were higher among individuals with TBI relative to control subjects. These findings suggest that, subsequent to TBI, the brain may undergo adaptation responses at the cellular level to compensate for functional impairment due to axonal injury.",{"EN":952},"Diffuse disconnectivity in traumatic brain injury: a resting state fMRI and DTI study",{"VOID":954},"Huisman T. A., Schwamm L. H., Schaefer P. W., Koroshetz W. J., Shetty-Alva N., Ozsunar Y. et al., Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury, AJNR Am. J. Neuroradiol., 2004, 25, 370–376\nScheid R., Walther K., Guthke T., Preul C., von Cramon D. Y., Cognitive sequelae of diffuse axonal injury, Arch. Neurol., 2006, 63, 418–424\nKou Z., Wu Z., Tong K. A., Holshouser B., Benson R. R., Hu J. et al., The role of advanced MR imaging findings as biomarkers of traumatic brain injury, J. Head Trauma Rehabil., 2010, 25, 267–282\nMcDowell S., Whyte J., D’Esposito M., Working memory impairments in traumatic brain injury: evidence from a dual-task paradigm, Neuropsychologia, 1997, 35, 1341–1353\nArciniegas D. B., Held K., Wagner P., Cognitive Impairment Following Traumatic Brain Injury, Curr. Treat. Options Neurol., 2002, 4, 43–57\nSchretlen D. J., Shapiro A. M., A quantitative review of the effects of traumatic brain injury on cognitive functioning, Int. Rev. Psychiatry, 2003, 15, 341–349\nHughes D. G., Jackson A., Mason D. L., Berry E., Hollis S., Yates D. W., Abnormalities on magnetic resonance imaging seen acutely following mild traumatic brain injury: correlation with neuropsychological tests and delayed recovery, Neuroradiology, 2004, 46, 550–558\nGuskiewicz K. M., Marshall S. W., Bailes J., McCrea M., Cantu R. C., Randolph C. et al., Association between recurrent concussion and late-life cognitive impairment in retired professional football players, Neurosurgery, 2005, 57, 719–726\nBasser P. J., Pajevic S., Pierpaoli C., Duda J., Aldroubi A., In vivo fiber tractography using DT-MRI data, Magn. Reson. Med., 2000, 44, 625–632\nWozniak J. R., Krach L., Ward E., Mueller B. A., Muetzel R., Schnoebelen S. et al., Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: A diffusion tensor imaging (DTI) study, Arch. Clin. Neuropsychol., 2007, 22, 555–568\nRutgers D. R., Toulgoat F., Cazejust J., Fillard P., Lasjaunias P., Ducreux D., White matter abnormalities in mild traumatic brain injury: a diffusion tensor imaging study, AJNR Am. J. Neuroradiol., 2008, 29, 514–519\nOgawa S., Lee T. M., Kay A. R., Tank D. W., Brain magnetic resonance imaging with contrast dependent on blood oxygenation, Proc. Natl. Acad. Sci. USA, 1990, 87, 9868–9872\nMcAllister T. W., Saykin A. J., Flashman L. A., Sparkling M. B., Johnson S. C., Mamourian A. C. et al., Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study, Neurology, 1999, 53, 1300–1308\nScheibel R. S., Pearson D. A., Faria L. P., Kotrla K. J., Aylward E., Bachevalier J. et al., An fMRI study of executive functioning after severe diffuse TBI, Brain Inj., 2003, 17, 919–930\nAzouvi P., Couillet J., Leclercq M., Martin Y., Asloun S., Rousseaux M., Divided attention and mental effort after severe traumatic brain injury, Neuropsychologia, 2004, 42, 1260–1268\nMaruishi M., Miyatani M., Nakao T., Muranaka H., Compensatory cortical activation during performance of an attention task by patients with diffuse axonal injury: a functional magnetic resonance imaging study, J. Neurol. Neurosurg. Psychiatry, 2007, 78, 168–173\nHaier R. J., Cerebral glucose metabolism and intelligence, In: Biological approaches to the study of human intelligence, Norwood, NJ: Ablex, 1993, 317–332\nTang C. Y., Eaves E. L., Ng J. C., Carpenter D. M., Kanellopoulou I., Mai X. et al., Brain networks for working memory and factors of intelligence assessed in males and females with fMRI and DTI, Intelligence, 2010, 38, 293–303\nGreicius M. D., Krasnow B., Reiss A. L., Menon V., Functional connectivity in the resting brain: A network analysis of the default mode hypothesis, Proc. Natl. Acad. Sci. USA, 2003, 100, 253–258\nDamoiseaux J. S., Rombouts S. A., Barkhof F., Scheltens P., Stam C. J., Smith S. M. et al., Consistent resting-state networks across healthy subjects, Proc. Natl. Acad. Sci. USA, 2006, 103, 13848–13853\nDe Luca M., Beckmann C. F., De Stefano N., Matthews P. M., Smith S. M., fMRI resting state networks define distinct modes of longdistance interactions in the human brain, Neuroimage, 2006, 29, 1359–1367\nMacDonald C. L., Schwarze N., Vaishnavi S. N., Epstein A. A., Snyder A. Z., Raichle M. E. et al., Verbal memory deficit following traumatic brain injury: assessment using advanced MRI methods, Neurology, 2008, 71, 1199–1201\nNakamura T., Hillary F. G., Biswal B. B., Resting network plasticity following brain injury, Plos One, 2009, 4, e8220\nSmith S. M., Jenkinson M., Johansen-Berg H., Rueckert D., Nichols T. E., Mackay C. E. et al., Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data, Neuroimage, 2006, 31, 1487–1505\nSmith S. M., Nichols T. E., Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference, Neuroimage, 2009, 44, 83–98\nBeckmann C. F., Smith S. M., Probabilistic independent component analysis for functional magnetic resonance imaging, IEEE Trans. Med. Imaging, 2004, 23, 137–152\nBenson R. R., Meda S. A., Vasudevan S., Kou Z., Govindarajan K. A., Hanks R. A. et al., Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury, J. Neurotraum., 2007, 24, 446–459\nXu J., Rasmussen I. A., Lagopoulos J., Håberg A., Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging, J. Neurotraum., 2007, 24, 753–765\nNobuhara K., Okugawa G., Sugimoto T., Minami T., Tamagaki C., Takase K. et al., Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study, J. Neurol. Neurosurg. Psychiatry, 2006, 77, 120–122\nHerrmann L. L., Le Masurier M., Ebmeier K. P., White matter hyperintensities in late life depression: a systematic review, J. Neurol. Neurosurg. Psychiatry, 2008, 79, 619–624\nGreicius M. D., Srivastava G., Reiss A. L., Menon V., Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: Evidence from functional MRI, Proc. Natl. Acad. Sci. USA, 2004, 101, 4637–4642\nSorg C., Riedl V., Mühlau M., Calhoun V. D., Eichele T., Läer L. et al., Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease, Proc. Natl. Acad. Sci. USA, 2007, 104, 18760–18765\nLiang M., Zhou Y., Jiang T., Liu Z., Tian L., Liu H. et al., Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging, Neuroreport, 2006, 17, 209–213\nCherkassky V. L., Kana R. K., Keller T. A., Just M. A., Functional connectivity in a baseline resting-state network in autism, Neuroreport, 2006, 17, 1687–1690\nHaier R. J., Siegel B. V. Jr., MacLachlan A., Soderling E., Lottenberg S., Buchsbaum M. S., Regional glucose metabolic changes after learning a complex visuospatial motor task — a positron emission tomographic study, Brain Res., 1992, 570, 134–143\nDavis S. W., Dennis N. A., Daselaar S. M., Fleck M. S., Cabeza R., Que PASA? The posterior-anterior shift in aging, Cereb. Cortex, 2008, 18, 1201–1209\nDamoiseaux J. S., Prater K. E., Miller B. L., Greicius M. D., Functional connectivity tracks clinical deterioration in Alzheimer’s disease, Neurobiol. Aging, 2011, epub ahead of print\nQi Z. G., Wu X., Wang Z., Zhang N., Dong H., Yao L. et al., Impairment and compensation coexist in amnestic MCI default mode network, Neuroimage, 2010, 50, 48–55",{"VOID":956},"10.2478\u002Fs13380-012-0003-3","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-012-0003-3\u002Fhtml",[959,983,996,1011,1026,1039,1052,1065,1078,1091],{"id":960,"sortIndex":21,"researcher":20,"roles":961,"affiliations":962,"properties":980,"displayName":982,"givenName":20,"familyName":20},"9912813e-317e-4b09-9261-096062417c9b",[133],[963,971],{"id":964,"sortIndex":21,"affiliation":965,"properties":20},"a533dbd3-76a9-43a9-89cc-9fce57ae8655",{"id":964,"createTime":20,"updateTime":20,"relativeEntities":966,"slug":20,"properties":967,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":970,"statistic":20},[],{"title":968},{"VI":969},"Department of Radiology, Mount Sinai School of Medicine, New York, USA",[],{"id":972,"sortIndex":104,"affiliation":973,"properties":979},"89be534d-76af-4497-8941-1548348aa188",{"id":972,"createTime":20,"updateTime":20,"relativeEntities":974,"slug":20,"properties":975,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":978,"statistic":20},[],{"title":976},{"VI":977},"Department of Psychiatry, Mount Sinai School of Medicine, New York USA",[],{},{"title":981},{"VI":982},"Cheuk Ying Tang",{"id":984,"sortIndex":104,"researcher":20,"roles":985,"affiliations":986,"properties":993,"displayName":995,"givenName":20,"familyName":20},"3a9a7606-e502-463e-ad05-27a9260361d0",[133],[987],{"id":964,"sortIndex":21,"affiliation":988,"properties":20},{"id":964,"createTime":20,"updateTime":20,"relativeEntities":989,"slug":20,"properties":990,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":992,"statistic":20},[],{"title":991},{"VI":969},[],{"title":994},{"VI":995},"Emily Eaves",{"id":997,"sortIndex":174,"researcher":20,"roles":998,"affiliations":999,"properties":1008,"displayName":1010,"givenName":20,"familyName":20},"dee142e8-acc5-4501-ae3e-b13e057f79d7",[133],[1000],{"id":1001,"sortIndex":21,"affiliation":1002,"properties":20},"7df5ebcd-7c27-4dd0-88db-1c1779c27a9d",{"id":1001,"createTime":20,"updateTime":20,"relativeEntities":1003,"slug":20,"properties":1004,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1007,"statistic":20},[],{"title":1005},{"VI":1006},"Department of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, USA",[],{"title":1009},{"VI":1010},"Kristen Dams-O’Connor",{"id":1012,"sortIndex":200,"researcher":20,"roles":1013,"affiliations":1014,"properties":1023,"displayName":1025,"givenName":20,"familyName":20},"6a21fa9e-3cd3-4d9d-8a5b-a1445ce52082",[133],[1015],{"id":1016,"sortIndex":21,"affiliation":1017,"properties":20},"62ce7d9a-4088-4092-a2aa-bdfd56850f4e",{"id":1016,"createTime":20,"updateTime":20,"relativeEntities":1018,"slug":20,"properties":1019,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1022,"statistic":20},[],{"title":1020},{"VI":1021},"Department of Neurology, Mount Sinai School of Medicine, New York, USA",[],{"title":1024},{"VI":1025},"Lap Ho",{"id":1027,"sortIndex":810,"researcher":20,"roles":1028,"affiliations":1029,"properties":1036,"displayName":1038,"givenName":20,"familyName":20},"39aba0bf-4a17-4f93-92f4-a174213d7b10",[133],[1030],{"id":964,"sortIndex":21,"affiliation":1031,"properties":20},{"id":964,"createTime":20,"updateTime":20,"relativeEntities":1032,"slug":20,"properties":1033,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1035,"statistic":20},[],{"title":1034},{"VI":969},[],{"title":1037},{"VI":1038},"Eric Leung",{"id":1040,"sortIndex":397,"researcher":20,"roles":1041,"affiliations":1042,"properties":1049,"displayName":1051,"givenName":20,"familyName":20},"a30b242f-2542-431e-af53-5aacffd71df6",[133],[1043],{"id":964,"sortIndex":21,"affiliation":1044,"properties":20},{"id":964,"createTime":20,"updateTime":20,"relativeEntities":1045,"slug":20,"properties":1046,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1048,"statistic":20},[],{"title":1047},{"VI":969},[],{"title":1050},{"VI":1051},"Edmund Wong",{"id":1053,"sortIndex":86,"researcher":20,"roles":1054,"affiliations":1055,"properties":1062,"displayName":1064,"givenName":20,"familyName":20},"9191d446-5f90-4eca-85e2-508571c3b910",[133],[1056],{"id":964,"sortIndex":21,"affiliation":1057,"properties":20},{"id":964,"createTime":20,"updateTime":20,"relativeEntities":1058,"slug":20,"properties":1059,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1061,"statistic":20},[],{"title":1060},{"VI":969},[],{"title":1063},{"VI":1064},"David Carpenter",{"id":1066,"sortIndex":105,"researcher":20,"roles":1067,"affiliations":1068,"properties":1075,"displayName":1077,"givenName":20,"familyName":20},"7812b640-d680-4a26-9dcc-29d32075a6ea",[133],[1069],{"id":964,"sortIndex":21,"affiliation":1070,"properties":20},{"id":964,"createTime":20,"updateTime":20,"relativeEntities":1071,"slug":20,"properties":1072,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1074,"statistic":20},[],{"title":1073},{"VI":969},[],{"title":1076},{"VI":1077},"Johnny Ng",{"id":1079,"sortIndex":393,"researcher":20,"roles":1080,"affiliations":1081,"properties":1088,"displayName":1090,"givenName":20,"familyName":20},"6dbf1101-929f-4fa6-bf01-a4c13a821a3c",[133],[1082],{"id":1001,"sortIndex":21,"affiliation":1083,"properties":20},{"id":1001,"createTime":20,"updateTime":20,"relativeEntities":1084,"slug":20,"properties":1085,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1087,"statistic":20},[],{"title":1086},{"VI":1006},[],{"title":1089},{"VI":1090},"Wayne Gordon",{"id":1092,"sortIndex":1093,"researcher":20,"roles":1094,"affiliations":1095,"properties":1118,"displayName":1120,"givenName":20,"familyName":20},"de059d74-d1cc-42a4-84dc-4f1d93c43182",9,[133],[1096,1102,1109],{"id":972,"sortIndex":21,"affiliation":1097,"properties":20},{"id":972,"createTime":20,"updateTime":20,"relativeEntities":1098,"slug":20,"properties":1099,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1101,"statistic":20},[],{"title":1100},{"VI":977},[],{"id":1016,"sortIndex":104,"affiliation":1103,"properties":1108},{"id":1016,"createTime":20,"updateTime":20,"relativeEntities":1104,"slug":20,"properties":1105,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1107,"statistic":20},[],{"title":1106},{"VI":1021},[],{},{"id":1110,"sortIndex":174,"affiliation":1111,"properties":1117},"b2cfc256-5d5e-43b1-85c0-a7a217abae85",{"id":1110,"createTime":20,"updateTime":20,"relativeEntities":1112,"slug":20,"properties":1113,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1116,"statistic":20},[],{"title":1114},{"VI":1115},"James J. Peters Veterans Affairs Medical Center, Bronx, USA",[],{},{"title":1119},{"VI":1120},"Giulio Pasinetti",{"url":957,"publisher":1122,"properties":1164},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1123,"slug":10,"properties":1124,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1128,"manageAffiliations":1133,"indexDatabases":1144,"url":20,"thumbnailPath":20,"statistic":1159,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":1125,"title":1126,"eissn":1127},{"VOID":13},{"EN":15},{"VOID":17},[1129],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1130,"label":1131,"description":1132,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[1134,1139],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":1135,"slug":20,"properties":1136,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1138,"statistic":20},[],{"title":1137},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":1140,"slug":20,"properties":1141,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1143,"statistic":20},[],{"title":1142},{"EN":42},[],[1145,1152],{"id":46,"indexDatabase":1146,"url":57,"indexYears":58,"academicFieldIds":1151,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1147,"label":1148,"description":1149,"key":54,"publicationTags":1150,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":1153,"url":76,"indexYears":20,"academicFieldIds":1158,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":1154,"label":1155,"description":1156,"key":72,"publicationTags":1157,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":1160,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":1161,"totalCitation":93,"totalCitationByYear":1162,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":1163,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":1165,"volume":1167},{"VOID":1166},"9-14",{"VOID":1168},"3","2012-03-14",2012,[61,74],{"id":1173,"createTime":1174,"updateTime":1175,"relativeEntities":1176,"slug":1177,"properties":1178,"entityType":125,"verifyStatus":126,"verifyTime":1175,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":104,"primaryUrl":1187,"fullTextUrl":20,"authors":1188,"publicationType":219,"publisherRelationship":1204,"citationCount":20,"citationInfo":20,"publishDate":1252,"publishYear":1253,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1254,"openAccess":20,"references":20,"isForceReanalyzing":271},"0c53c924-3340-4b2d-b361-ca26c084fc3d","2024-01-27T00:26:03.672+00:00","2025-02-23T19:08:33.905+00:00",[],"F-K-Studni%C4%8Dka-1894-Fishes-and-amphibians-also-have-the-cerebral-cortex",{"abstract":1179,"title":1181,"references":1183,"doi":1185},{"EN":1180},"The aim of this paper is to provide translation of probably the first report (Studnička 1894) demonstrating that the telencephalon of all vertebrate taxa (including fishes and amphibians) is characterized by the presence of the cerebral cortex (pallium). This report was one of those initiating a century-long and still not fully resolved discussion concerning homologies of various pallial subdivisions in different vertebrate taxa and probably the first to draw attention to the importance of careful study of the pallium in representatives of agnathans (Cyclostomes) such as lampreys (Petromyzonts) and hagfishes (Myxinoids). This article also briefly reviews the current status of comparative research on vertebrate telencephalon, and provides historical notes which position Studnička’s report in its historical context.",{"EN":1182},"F. K. Studnička (1894): Fishes and amphibians also have the cerebral cortex",{"VOID":1184},"Butler A. B., Hodos W., Comparative Vertebrate Neuroanatomy. Evolution and Adaptation, 2nd Edition, Hoboken, New Jersey: Wiley-Interscience, 2005\nKaas J. H., Bullock T. H., Evolution of Nervous Systems. A Comprehensive Reference, Volume 2: Non-Mammalian Vertebrates, Oxford — San Diego: Academic Press, 2007\nStriedter G., Principles of Brain Evolution, Sinauer Associates, 2005\nFurlong R. F., Holland P. W. H., Bayesian phylogenetic analysis supports monophyly of Ambulacraria and of cyclostomes, Zoological Science 2002, 19, 593–599\nMallat J., Sullivan J., 28S and 18S rDNA sequences support the monophyly of lampreys and hagfishes, Mol Biol Evol, 1998, 15, 1706–1718\nBruce L.L., Evolution of the nervous system in Reptiles, In: Kaas J.H., Bullock T.H. (Eds) Evolution of Nervous Systems Vol. 2, Oxford-San Diego: Academic Press, 2007, 125–156\nWullimann M. F., Vernier P., Evolution of the nervous system in fishes, In: Kaas J.H., Bullock T.H. (Eds) Evolution of Nervous Systems Vol. 2, Oxford-San Diego: Academic Press, 2007, 39–60\nPuelles L., Brain segmentation and forebrain development in amniotes, Brain Res Bull, 2007, 55, 695–710\nBruce L.L., Neary T.J., The limbic system of tetrapods: A comparative analysis of cortical and amygdalar populations, Brain Behav Evol, 1995, 46, 224–234\nWullimann M.F., Mueller T., Teleostean and mammalian forebrains contrasted: Evidence from genes to behavior, J Comp Neurol 2004, 475, 143–162\nBraun C.B., The sensory biology of lampreys and hagfishes: A phylogenetic assessment, Brain Behav Evol 1996, 48, 262–276\nWicht H., The brains of lampreys and hagfishes: Characteristics, characters, and comparisons, Brain Behav Evol 1996, 48, 248–261\nWicht H., Northcutt R.G., The forebrain of the pacific hagfish: A cladistic reconstruction of the ancestral craniate forebrain, Brain Behav Evol, 1992, 40, 25–64\nWicht H., Northcutt R.G., Telencephalic connections in the Pacific hagfish (Eptatretus stouti), with special reference to the thalamopallial system, J Comp Neurol 1998, 395, 245–260\nPolenova O. A., Vesselkin N. P., Olfactory and non-olfactory projections in the river lamprey (Lampetra fluviatilis) telencephalon, J Hirnforsch, 1993, 34, 261–279\nMurakami Y., Uchida K., Rijli F. M., Kuratani S., Evolution of the brain developmental plan: Insights from agnathans, Dev Biol, 2005, 280, 249–259\nDicke U., Roth G., Evolution of the Amphibian nervous system, In: Kaas JH, Bullock TH (Eds) Evolution of Nervous Systems Vol. 2, Oxford-San Diego: Academic Press, 2007, 61–124\nBrinkmann H., Denk A., Zitzler J., Joss J. J., Meyer A., Complete mitochondrial genome sequences of the South American and the Australian lungfish: Testing of the phylogenetic performance of mitochondrial data sets for phylogenetic problems in tetrapod relationships, J Mol Evol, 2004, 59, 834–848\nKuhlenbeck H., Zur Morphologie des Gymnophionengehirns, Jenaische Zeitschrift für Naturwissenschaften, 1922, 58, 453–484\nHerrick C. J., The Brain of the Tiger Salamander Ambystoma tigrinum, Chicago: University of Chicago Press, 1948\nGregory T. R., Genome size and developmental complexity, Genetica, 2002, 115, 131–146\nGregory T. R., Variation across amphibian species in the size of the nuclear genome supports a pluralistic, hierarchical approach to the C-value enigma, Biol J Linn Soc 2002, 79, 329–339\nNorthcutt R. G., Evolution of the telencephalon in nonmammals, Ann Rev Neurosci 1981, 4, 301–350\nWesthoff G., Roth G., Morphology and projection pattern of medial and dorsal pallial neurons in the frog Discoglossus pictus and the salamander Plethodon jordani, J Comp Neurol, 2002, 445, 97–121\nReiner A., Perkel D. J., Bruce L. L., Butler A. B., Csillag A., Kuenzel W., et al., Revised nomenclature for avian telencephalon and some related brainstem nuclei, J Comp Neurol, 2004, 473, 377–414\nShepherd GM (1991) Foundations of the Neuron Doctrine. New York — Oxford: Oxford University Press.\nJacobson M., Developmental Neurobiology, Third Edition, New York — London: Plenum Press, 1991",{"VOID":1186},"10.2478\u002Fs13380-011-0010-9","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-011-0010-9\u002Fhtml",[1189],{"id":1190,"sortIndex":21,"researcher":20,"roles":1191,"affiliations":1192,"properties":1201,"displayName":1203,"givenName":20,"familyName":20},"0f6968e2-3df0-459c-aa50-90d3fc354d64",[133],[1193],{"id":1194,"sortIndex":21,"affiliation":1195,"properties":20},"4ce2bdd2-3402-4eb7-ac16-c6b64d5de0ef",{"id":1194,"createTime":20,"updateTime":20,"relativeEntities":1196,"slug":20,"properties":1197,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1200,"statistic":20},[],{"title":1198},{"EN":1199},"Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia",[],{"title":1202},{"VI":1203},"Miloš Judaš",{"url":1187,"publisher":1205,"properties":1247},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1206,"slug":10,"properties":1207,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1211,"manageAffiliations":1216,"indexDatabases":1227,"url":20,"thumbnailPath":20,"statistic":1242,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":1208,"title":1209,"eissn":1210},{"VOID":13},{"EN":15},{"VOID":17},[1212],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1213,"label":1214,"description":1215,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[1217,1222],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":1218,"slug":20,"properties":1219,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1221,"statistic":20},[],{"title":1220},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":1223,"slug":20,"properties":1224,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1226,"statistic":20},[],{"title":1225},{"EN":42},[],[1228,1235],{"id":46,"indexDatabase":1229,"url":57,"indexYears":58,"academicFieldIds":1234,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1230,"label":1231,"description":1232,"key":54,"publicationTags":1233,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":1236,"url":76,"indexYears":20,"academicFieldIds":1241,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":1237,"label":1238,"description":1239,"key":72,"publicationTags":1240,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":1243,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":1244,"totalCitation":93,"totalCitationByYear":1245,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":1246,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":1248,"volume":1250},{"VOID":1249},"79-89",{"VOID":1251},"2","2011-03-26",2011,[61,74],{"id":1256,"createTime":1257,"updateTime":1258,"relativeEntities":1259,"slug":1260,"properties":1261,"entityType":125,"verifyStatus":126,"verifyTime":1258,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1270,"fullTextUrl":20,"authors":1271,"publicationType":219,"publisherRelationship":1300,"citationCount":20,"citationInfo":20,"publishDate":1347,"publishYear":1253,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1348,"openAccess":20,"references":20,"isForceReanalyzing":271},"4eaf94b7-317b-4222-b2db-84f118a63872","2024-01-05T13:58:54.496+00:00","2025-02-22T22:21:42.533+00:00",[],"Stem-cell-therapy-for-neurological-disorders",{"abstract":1262,"title":1264,"references":1266,"doi":1268},{"EN":1263},"Stem cells have long been in focus as potential therapy or even cure for a whole myriad of diseases. Many neurodegenerative disorders, both acute and chronic, are characterized by irreversible neuronal damage and loss, and only a few efficient treatment options exist. In contrast to many other tissues, the potential of self-regeneration of the central nervous system is highly limited. There is hope that stem cells could replace the damaged neuronal and glial cells, and provide biological and functional restoration based on their properties of self renewal and the ability to give rise to different cells. In recent years, the promising results of research on animal models has led to the establishment of the first clinical trials; although no clear evidence of therapeutic benefit for any of the conditions have been ascertained. Here we give a review of the current strategies of stem-cell based therapy for some of the more common neurological disorders, discussing the progress and current challenges, and giving an overview of future perspectives.",{"EN":1265},"Stem cell therapy for neurological disorders",{"VOID":1267},"Park D. H., Eve D. J., Chung Y. G., Sanberg P. R., Regenerative medicine for neurological disorders, ScientificWorldJournal, 2010, http:\u002F\u002Fwww. tswj.com\u002F2010\u002F463612\u002Fabs\u002F\nSrivastava A. S., Malhotra R., Sharp J., Berggren T., Potentials of ES cell therapy in neurodegenerative diseases, Curr. Pharm. Design., 2008, 14, 3873–3879\nTakahashi K., Yamanaka S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell, 2006, 126, 663–676\nBaker M., Stem cells: Fast and furious, Nature, 2009, 458, 462–465\nMattis V. B., Svendsen C. N., Induced pluripotent stem cells: a new revolution for clinical neurology?, Lancet Neurol., 2011, 10, 383–394\nPark I. H., Arora N., Huo H., Maherali N., Ahfeldt T., Shimamura A. et al., Disease specific induced pluripotent stem cells, Cell, 2008, 134, 877–886\nDurnaoglu S., Genc S., Genc K., Patient-specific pluripotent stem cells in neurological diseases, Stem Cells Int., 2011, http:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fsci\u002F2011\u002F212487\u002F\nDoetsch F., Caille I., Lim D.A., Garcia-Verdugo J.M., Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain, Cell 97, 1999, 703–716\nReynolds B. A., Weiss S., Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system, Science, 1992, 255, 1707–1710\nEriksson P. S., Perfilieva E., Bjork-Eriksson T., Alborn A. M., Nordborg C., Peterson D. A. et al., Neurogenesis in the adult human hippocampus, Nat. Med., 1998, 4, 1313–1317\nAlvarez-Buylla A., García-Verdugo J. M., Tramontin A. D., A unified hypothesis on the lineage of neural stem cells, Nat. Rev. Neurosci., 2001, 2, 287–293\nKempermann G., Wiskott L., Gage F. H., Functional significance of adult neurogenesis, Curr. Opin. Neurobiol., 2004, 14, 186–191\nKempermann G. Seven principles in the regulation of adult neurogenesis. Eur J Neurosci., 2011, 33, 1018–24\nZhao C., Deng W., Gage F. H., Mechanisms and functional implications of adult neurogenesis, Cell, 2008, 132, 645–660\nJin K., Sun Y., Xie L., Peel A., Mau X. O., Batteur S. et al., Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum, Mol. Cell. Neurosci., 2003, 24, 171–189\nEmery D. L., Fulp C. T., Saatman K. E., Schutz C., Neugebauer E., McIntosh T. K., Newly born granule cells in the dentate gyrus rapidly extend axons into the hippocampal CA3 region following experimental brain injury, J. Neurotrauma, 2005, 22, 978–988\nPicard-Riera N., Decker L., Delarasse C., Goude K., Nait-Oumesmar B., Liblau R. et al., Experimental autoimmune encephalomyelitis mobilized neuronal progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice, Proc. Natl. Acad. Sci. U S A, 2002, 99, 13211–13216\nHattiangady B., Shuai B., Cai J., Coksaygan T., Rao M. S., Shetty A. K., Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus, Stem cells, 2007, 25, 2104–2117\nMunoz J. R., Stoutenger B. R., Robinson A. P., Spees J. L., Prockop D. J., Human stem\u002Fprogenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice, Proc. Natl. Acad. Sci. U S A, 2005, 102, 18171–18176, Erratum in: Proc. Natl. Acad. Sci. U S A, 2006, 103, 2000–2002\nMartino G., Pluchino S., The therapeutic potential of neural stem cells, Nat. Rev. Neurosci., 2006, 7, 395–406\nLindvall O., Kokaia Z., Stem cells for the treatment of neurological disorders, Nature, 2006, 441, 1094–1096\nLindvall O., Kokaia Z., Stem cells in human neurodegenerative disorders—time for clinical translation?, J. Clin. Invest., 2010, 120, 29–40\nPolgar S., Morris M. E., Reilly S., Bilney B., Sanberg P. R., Reconstructive neurosurgery for Parkinson’s disease: a systematic review and preliminary meta-analysis, Brain Res. Bull., 2003, 60, 1–24\nLindvall O., Björklund A., Cell therapy in Parkinson’s disease, NeuroRx., 2004, 1, 382–393\nBrazzini A., Cantella R., De la Cruz A., Yupanqui J., León C., Jorquiera T. et al., Intraarterial autologous implantation of adult stem cells for patients with Parkinson disease, J. Vasc. Interv. Radiol., 2010, 21, 443–451\nVenkataramana N. K., Kumar S. K., Balaraju S., Radhakrishnan R. C., Bansal A., Dixit A. et al., Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson’s disease, Transl. Res., 2010, 155, 62–70\nLévesque M. F., Neuman T., Rezak M., Therapeutic microinjection of autologous adult human neural stem cells and differentiated neurons for Parkinson’s disease: five-year post-operative outcome, Open Stem Cell J., 2009, http:\u002F\u002Fbenthamscience.com\u002Fopen\u002Ftoscj\u002Fopenaccess2.htm\nHagell P., Piccini P., Björklund A., Brundin P., Rehncrona S., Widner H. et al., Dyskinesias following neural transplantation in Parkinson’s disease, Nat. Neurosci., 2002, 5, 627–628\nLang A. E., Obeso J. A., Challenges in Parkinson’s disease: restoration of the nigrostriatal dopamine system is not enough, Lancet Neurol., 2004, 3, 309–316\nBehrstock S., Ebert A., McHugh J., Vosberg S., Moore J., Schneider B. et al., Human neural progenitors deliver glial cell line-derived neurotrophc factor to parkinsonian rodents and aged primates, Gene Ther., 2006, 13, 379–388\nBachoud-Lévi A. C., Gaura V., Brugières P., Lefaucheur J. P., Boissé M. F., Maison P. et al., Effect of fetal neural transplants in patients with Huntington’s disease 6 years after surgery: a long-term follow-up study, Lancet Neurol., 2006, 5, 303–309\nLescaudron L., Unni D., Dunbar G. L., Autologous adult bone marrow stem cell transplantation in an animal model of Huntington’s disease: behavioral and morphological outcomes, Int. J. Neurosci., 2003, 113, 945–956\nMcBride J. L., Behrstock S. P., Chen E. Y., Jakel R. J., Siegel I., Svendsen C. N. et al., Human neural stem cell transplants improve motor function in a rat model of Huntington’s disease, J. Comp. Neurol., 2004, 475, 211–219\nEbert A. D., Barber A. E., Heins B. M., Svendsen C. N., Ex vivo delivery ofGDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington’s disease, Exp. Neurol., 2010, 224, 155–162\nSilani V., Cova L., Corbo M., Ciammola A., Polli E., Stem-cell therapy for amyotrophic lateral sclerosis, Lancet, 2004, 364, 200–202\nBorchelt D. R., Amyotrophic lateral sclerosis-are microglia killing motor neurons?, N. Engl. J. Med., 2006, 12, 1611–1613\nClement A. M., Nguyen M. D., Roberts E. A., Garcia M. L., Boillée S., Rule M. et al., Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice, Science, 2003, 302, 113–117\nLepore A. C., Rauck B., Dejea C., Pardo A. C., Rao M.S., Rothstein J. D. et al., Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease, Nat. Neurosci, 2008, 11, 1294–1301\nMazzini L., Ferrero I., Luparello V., Rustichelli D., Gunetti M., Mareschi K. et al., Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial, Exp. Neurol., 2010, 223, 229–237\nMartinez H. R., Gonzalez-Garza M. T., Moreno-Cuevas J. E., Caro E., Gutierrez-Jimenez E., Segura J. J., Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients, Cytotherapy, 2009, 11, 26–34\nDeda H., Inci M. C., Kürekçi A. E., Sav A., Kayihan K., Ozgün E., Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up, Cytotherapy, 2009, 11, 18–25\nKarussis D., Karageorgiou C., Vaknin-Dembinsky A., Gowda-Kurkalli B., Gomori J. M., Kassis I. et al., Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis, Arch. Neurol., 2010, 67, 1187–1194\nLunn J. S., Sakowski S. A., Hur J., Feldman E. L., Stem cell technology for neurodegenerative diseases, Ann. Neurol., 2011, 70, 353–361\nMartino G., Franklin R. J., Van Evercooren A. B., Kerr D. A., Stem Cells in Multiple Sclerosis (STEMS) Consensus Group. Stem cell transplantation in multiple sclerosis: current status and future prospects, Nat. Rev. Neurol., 2010, 6, 247–255\nScolding N., Adult stem cells and multiple sclerosis, Cell Prolif., 2011, 44(Suppl. 1), 35–38\nFassas A., Anagnostopoulos A., Kazis A., Kapinas K., Sakellari I., Kimiskidis V. et al., Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study, Bone Marrow Transplant., 1997, 20, 631–638\nFassas A., Passweg J. R., Anagnostopoulos A., Kazis A., Kozak T., Havrdova E. et al., Autoimmune disease working party of the EBMT (European Group for Blood and Marrow Transplantation). Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study, J. Neurol., 2002, 249, 1088–1097\nFassas A., Kimiskidis V. K., Sakellari I., Kapinas K., Anagnostopoulos A., Tsimourtou V. et al., Long-term results of stem cell transplantation for MS: a single-center experience, Neurology, 2011, 76, 1066–1070\nBurt R. K., Loh Y., Cohen B., Stefoski D., Balabanov R., Katsamakis G. et al., Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I\u002FII study, Lancet Neurol., 2009, 8, 244–253, Erratum in: Lancet Neurol., 2009, 8, 309\nCummings B. J., Uchida N., Tamaki S. J., Salazar D. L., Hooshmand M., Summers R. et al., Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice, Proc. Natl. Acad. Sci. U S A, 2005, 102, 14069–14074\nKeirstead H. S., Nistor G., Bernal G., Totoiu M., Cloutier F., Sharp K. et al., Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury, J. Neurosci., 2005, 25, 4694–4705\nLee S. H., Chung Y. N., Kim Y. H., Kim Y. J., Park J. P., Kwon D. K. et al., Effects of human neural stem cell transplantation in canine spinal cord hemisection, Neurol. Res., 2009, 31, 996–1002\nSharp J., Frame J., Siegenthaler M., Nistor G., Keirstead H. S., Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury, Stem Cells, 2010, 28, 152–163\nPal R., Venkataramana N. K., Bansal A., Balaraju S., Jan M., Chandra R. et al., Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury\u002Fparaplegia: a pilot clinical study, Cytotherapy, 2009, 11, 897–911\nYoon S. H., Shim Y. S., Park Y. H., Chung J. K., Nam J. H., Kim M. O. et al., Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I\u002FII clinical trial, Stem Cells, 2007, 25, 2066–2073\nHofstetter C. P., Holmstrom N. A., Lilja J. A., Schweinhardt P., Hao J., Spenger C. et al., Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome, Nat. Neurosci., 2005, 8, 346–353\nMacias M. Y., Syring M. B., Pizzi M. A., Crowe M. J., Alexanian A. R., Kurpad S.N. Pain with no gain: Allodynia following neural stem cell transplantation in spinal cord injury, Exp. Neurol., 2006, 201, 335–348\nThored P., Arvidsson A., Cacci E., Ahlenius H., Kallur T., Darsalia V. et al., Persistent production of neurons from adult brain stem cells during recovery after stroke, Stem Cells, 2006, 24, 739–747\nLuo Y., Cell-based therapy for stroke, J. Neural. Transm., 2011, 118, 61–74\nShyu W. C., Lee Y. J., Liu D. D., Lin S. Z., Li H., Homing genes, cell therapy and stroke, Front. Biosci., 2006, 11, 899–907\nBorlongan C. V., Hadman M., Sanberg C. D., Sanberg P. R., Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke, Stroke, 2004, 35, 2385–2389\nBliss T., Guzman R., Daadi M., Steinberg G. K., Cell transplantation therapy for stroke, Stroke, 2007, 38(Suppl. 2), 817–826\nKondziolka D., Steinberg G. K., Wechsler L., Meltzer C., Elder E., Gebel J. et al., Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial, J. Neurosurg., 2005, 103, 38–45\nSavitz S. I., Dinsmore J., Wu J., Henderson G. V., Stieg P., Caplan L. R., Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study, Cerebrovasc. Dis., 2005, 20, 101–107\nBang O. Y., Lee J. S., Lee P. H., Lee G., Autologous mesenchymal stem cell transplantation in stroke patients, Ann. Neurol., 2005, 57, 874–882\nHonmou O., Houkin K., Matsunaga T., Niitsu Y., Ishiai S., Onodera R. et al., Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke, Brain, 2011, 134, 1790–1807\nLee J. S., Hong J. M., Moon G. J., Lee P. H., Ahn Y. H., Bang O. Y. et al., A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke, Stem Cells, 2010, 28, 1099–1106\nChopp M., Li Y., Treatment of stroke and intracerebral hemorrhage with cellular and pharmacological restorative therapies, Acta Neurochir. Suppl., 2008, 105, 79–83\nShyu W. C., Lin S. Z., Lee C. C., Liu D. D., Li H., Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial, CMAJ, 2006, 174, 927–933\nTang K. C., Trzaska K. A., Smimov S., Kotenko S. V., Schwander S. K., Ellner J. J. et al., Down-regulation of MHC-II in mesenchimal stem cells at high IFN can be partly explained by cytoplasmic retention of CIITA, J. Immunol., 2008, 180, 1826–1833",{"VOID":1269},"10.2478\u002Fs13380-011-0040-3","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-011-0040-3\u002Fhtml",[1272,1287],{"id":1273,"sortIndex":21,"researcher":20,"roles":1274,"affiliations":1275,"properties":1284,"displayName":1286,"givenName":20,"familyName":20},"423ba3d4-f1e3-4fa6-b609-cf95162e3e8b",[133],[1276],{"id":1277,"sortIndex":21,"affiliation":1278,"properties":20},"36a4f5ab-ea96-4792-aa50-d72f5f6adf0f",{"id":1277,"createTime":20,"updateTime":20,"relativeEntities":1279,"slug":20,"properties":1280,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1283,"statistic":20},[],{"title":1281},{"VI":1282},"University Department of Neurology, University Hospital Sveti Duh, Zagreb, Croatia",[],{"title":1285},{"VI":1286},"Koraljka Bačić Baronica",{"id":1288,"sortIndex":104,"researcher":20,"roles":1289,"affiliations":1290,"properties":1297,"displayName":1299,"givenName":20,"familyName":20},"266d0d5d-49b1-4d8e-8fe3-c4a3ac689ac2",[133],[1291],{"id":1277,"sortIndex":21,"affiliation":1292,"properties":20},{"id":1277,"createTime":20,"updateTime":20,"relativeEntities":1293,"slug":20,"properties":1294,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1296,"statistic":20},[],{"title":1295},{"VI":1282},[],{"title":1298},{"VI":1299},"Latica Friedrich",{"url":1270,"publisher":1301,"properties":1343},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1302,"slug":10,"properties":1303,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1307,"manageAffiliations":1312,"indexDatabases":1323,"url":20,"thumbnailPath":20,"statistic":1338,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":1304,"title":1305,"eissn":1306},{"VOID":13},{"EN":15},{"VOID":17},[1308],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1309,"label":1310,"description":1311,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[1313,1318],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":1314,"slug":20,"properties":1315,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1317,"statistic":20},[],{"title":1316},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":1319,"slug":20,"properties":1320,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1322,"statistic":20},[],{"title":1321},{"EN":42},[],[1324,1331],{"id":46,"indexDatabase":1325,"url":57,"indexYears":58,"academicFieldIds":1330,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1326,"label":1327,"description":1328,"key":54,"publicationTags":1329,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":1332,"url":76,"indexYears":20,"academicFieldIds":1337,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":1333,"label":1334,"description":1335,"key":72,"publicationTags":1336,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":1339,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":1340,"totalCitation":93,"totalCitationByYear":1341,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":1342,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":1344,"volume":1346},{"VOID":1345},"319-324",{"VOID":1251},"2011-12-28",[61,74],{"id":1350,"createTime":1351,"updateTime":1352,"relativeEntities":1353,"slug":1354,"properties":1355,"entityType":125,"verifyStatus":19,"verifyTime":1352,"verifyNote":1366,"languages":1367,"translateLanguages":20,"viewCount":21,"primaryUrl":1368,"fullTextUrl":20,"authors":1369,"publicationType":219,"publisherRelationship":1419,"citationCount":104,"citationInfo":1462,"publishDate":1465,"publishYear":1463,"citationAnalyzeStatus":399,"lastCitationAnalyze":1466,"indexDatabases":1467,"openAccess":20,"references":1468,"isForceReanalyzing":271},"8d915e27-35d4-4464-b220-3cc39cf46dbc","2024-04-12T02:46:33.572+00:00","2025-02-21T18:08:17.363+00:00",[],"Deep-brain-stimulation-facilitates-memory-in-a-model-of-Alzheimer-s-disease",{"openalex":1356,"mag":1358,"abstract":1360,"title":1362,"doi":1364},{"VOID":1357},"W2025308912",{"VOID":1359},"2025308912",{"EN":1361},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Based on evidence suggesting that deep brain stimulation (DBS) may promote certain cognitive processes, we have been interested in developing DBS as a means of mitigating memory and learning impairments in Alzheimer’s disease (AD). In this study we used an animal model of AD (TgCRND8 mice) to determine the effects of high-frequency stimulation (HFS) on non-amyloidogenic α-secretase activity and DBS in short-term memory. We tested our hypothesis using hippocampal slices (in vitro studies) from TgCRND8 mice to evaluate whether HFS increases α-secretase activity (non-amyloidogenic pathway) in the CA1 region. In a second set of experiments, we performed in vivo studies to evaluate whether DBS in midline thalamic region re-establishes hippocampal dependent short-term memory in TgCRND8 mice. The results showed that application of HFS to isolated hippocampal slices significantly increased synaptic plasticity in the CA1 region and promoted a 2-fold increase of non-amyloidogenic α-secretase activity, in comparison to low frequency stimulated controls from TgCRND8 mice. In the in vivo studies, DBS treatment facilitated acquisition memory in TgCRND8 mice, in comparison to their own baseline before treatment. These results provide evidence that DBS could enhance short-term memory in a mouse model of AD by increasing synaptic transmission and α-secretase activity in the CA1 region of hippocampus.\u003C\u002Fjats:p>",{"EN":1363},"Deep brain stimulation facilitates memory in a model of Alzheimer’s disease",{"VOID":1365},"10.2478\u002Fv10134-010-0026-7","Author affiliation is blank",[294],"https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fv10134-010-0026-7\u002Fhtml",[1370,1389,1408],{"id":1371,"sortIndex":21,"researcher":20,"roles":1372,"affiliations":1373,"properties":1382,"displayName":1386,"givenName":20,"familyName":20},"84229113-a0d7-443d-a73c-d6cc49d21ea8",[],[1374],{"id":1375,"sortIndex":21,"affiliation":1376,"properties":20},"ab8d004c-f1db-49f1-82fc-c674b070d654",{"id":1375,"createTime":20,"updateTime":20,"relativeEntities":1377,"slug":20,"properties":1378,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1381,"statistic":20},[],{"title":1379},{"VI":1380},"Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA",[],{"orcid":1383,"title":1385,"openalex":1387},{"VOID":1384},"https:\u002F\u002Forcid.org\u002F0000-0003-3678-9288",{"EN":1386},"Isabel Arrieta‐Cruz",{"VOID":1388},"A5004652502",{"id":1390,"sortIndex":104,"researcher":20,"roles":1391,"affiliations":1392,"properties":1401,"displayName":1405,"givenName":20,"familyName":20},"9d252beb-7014-4a5f-86ff-c02f4e0924d0",[],[1393],{"id":1394,"sortIndex":21,"affiliation":1395,"properties":20},"09c4a4c4-8ae3-4c66-ab79-c2fd80c1fba9",{"id":1394,"createTime":20,"updateTime":20,"relativeEntities":1396,"slug":20,"properties":1397,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1400,"statistic":20},[],{"title":1398},{"EN":1399},"Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA",[],{"orcid":1402,"title":1404,"openalex":1406},{"VOID":1403},"https:\u002F\u002Forcid.org\u002F0000-0002-7627-4097",{"EN":1405},"Constantine Pavlides",{"VOID":1407},"A5038291313",{"id":1409,"sortIndex":174,"researcher":20,"roles":1410,"affiliations":1411,"properties":1412,"displayName":1416,"givenName":20,"familyName":20},"031a5787-58f4-4a85-a465-ea116def1cf0",[],[],{"orcid":1413,"title":1415,"openalex":1417},{"VOID":1414},"https:\u002F\u002Forcid.org\u002F0000-0002-1524-5196",{"EN":1416},"Giulio Maria Pasinetti",{"VOID":1418},"A5048364336",{"url":20,"publisher":1420,"properties":20},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1421,"slug":10,"properties":1422,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1426,"manageAffiliations":1431,"indexDatabases":1442,"url":20,"thumbnailPath":20,"statistic":1457,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":1423,"title":1424,"eissn":1425},{"VOID":13},{"EN":15},{"VOID":17},[1427],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1428,"label":1429,"description":1430,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[1432,1437],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":1433,"slug":20,"properties":1434,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1436,"statistic":20},[],{"title":1435},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":1438,"slug":20,"properties":1439,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1441,"statistic":20},[],{"title":1440},{"EN":42},[],[1443,1450],{"id":46,"indexDatabase":1444,"url":57,"indexYears":58,"academicFieldIds":1449,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1445,"label":1446,"description":1447,"key":54,"publicationTags":1448,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":1451,"url":76,"indexYears":20,"academicFieldIds":1456,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":1452,"label":1453,"description":1454,"key":72,"publicationTags":1455,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":1458,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":1459,"totalCitation":93,"totalCitationByYear":1460,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":1461,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"total":104,"publishYear":1463,"statisticByYear":1464},2010,{"2018":104},"2010-01-01","2024-04-13T11:15:42.334+00:00",[61,74],[1469,1473,1476,1480,1483,1487,1491,1495,1499,1502,1505,1509,1513,1517],{"id":20,"text":1470,"url":20,"identifiers":1471},"Kringelbach ML, Jenkinson N, Owen S, Aziz TZ, Translational principles of deep brain stimulation, Nature Rev Neuroscience, 8 (2007) 623–635.",{"doi":1472},"10.1038\u002Fnrn2196",{"id":20,"text":1474,"url":20,"identifiers":1475},"Hu R, Eskandar E, Williams Z, Role of deep brain stimulation in modulating memory formation and recall, Neurosurg Focus 27 (2009) 1–5.",{},{"id":20,"text":1477,"url":20,"identifiers":1478},"Shirvalkar P, Seth M, Schiff ND, Herrera DG, Cognitive enhancement with central thalamic electrical stimulation, Proc Natl Acad Sci U S A, 103 (2006) 17007–17012.",{"doi":1479},"10.1073\u002Fpnas.0604811103",{"id":20,"text":1481,"url":20,"identifiers":1482},"Paxinos G, Franklin K BJ, The Mouse Brain in Stereotaxic Coordinates, Second edition, (2001) Academic Press.",{},{"id":20,"text":1484,"url":20,"identifiers":1485},"Mitchell AS, Dalrymple-Alford JC, Lateral and anterior thalamic lesions impair independent memory systems, Learn Mem, 13 (2006) 388–396.",{"doi":1486},"10.1101\u002Flm.122206",{"id":20,"text":1488,"url":20,"identifiers":1489},"Arrieta I, Díaz-Ibáñez LB, Morales T, Mendoza-Garcés L, Morimoto S, Moreno-Mendoza N, Cerbón MA, Progesterone receptor gene and protein expression in the anterior preoptic area and hypothalamus of defeminized rats. J Neurobiol, 56 (2003) 338–346.",{"doi":1490},"10.1002\u002Fneu.10241",{"id":20,"text":1492,"url":20,"identifiers":1493},"Bellucci A, Luccarini I, Scali C, Prosperi C, Giovannini MG, Pepeu G, Casamenti F, Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice. Neurobiol Dis 23 (2006) 260–272.",{"doi":1494},"10.1016\u002Fj.nbd.2006.03.012",{"id":20,"text":1496,"url":20,"identifiers":1497},"Ye H, Jalini S, Mylvaganam S, Carlen P, Activation of largeconductance Ca(2+)-activated K(+) channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe\u002Find) TgCRND8 mice. Neurobiol. Aging. doi:10.1016\u002Fj.neurobiolaging.2008.05.012",{"doi":1498},"10.1016\u002Fj.neurobiolaging.2008.05.012",{"id":20,"text":1500,"url":20,"identifiers":1501},"Steriade M, in Thalamus eds. Steriade M, Jones E, McCormick D. Elsevier, Amsterdam (1997) 721–742.",{},{"id":20,"text":1503,"url":20,"identifiers":1504},"Schiff ND, Purpura, KP, Towards a neurophysiological foundation for cognitive neuromodulation through deep brain stimulation. Thalamus and Related Systems 2 (2002) 55–69.",{},{"id":20,"text":1506,"url":20,"identifiers":1507},"Farber SA, Nitsch RM, Schulz JG, Wurtman RJ, Regulated secretion of beta-amyloid precursor protein in rat brain, J Neurosci, 15 (1995) 7442–7451.",{"doi":1508},"10.1523\u002FJNEUROSCI.15-11-07442.1995",{"id":20,"text":1510,"url":20,"identifiers":1511},"Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC, BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions, J Neurosci, 25 (2005) 11693–11709.",{"doi":1512},"10.1523\u002FJNEUROSCI.2766-05.2005",{"id":20,"text":1514,"url":20,"identifiers":1515},"Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D, Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695, J Biol Chem, 276 (2001) 21562–21570.",{"doi":1516},"10.1074\u002Fjbc.M100710200",{"id":20,"text":1518,"url":20,"identifiers":1519},"Chapman PF, White GL., Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry., Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK, Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice, Nat Neurosci, 2 (1999) 271–276.",{"doi":1520},"10.1038\u002F6374",{"id":1522,"createTime":1523,"updateTime":1524,"relativeEntities":1525,"slug":1526,"properties":1527,"entityType":125,"verifyStatus":126,"verifyTime":1524,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1536,"fullTextUrl":20,"authors":1537,"publicationType":219,"publisherRelationship":1627,"citationCount":20,"citationInfo":20,"publishDate":1674,"publishYear":269,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1675,"openAccess":20,"references":20,"isForceReanalyzing":271},"6f0e0f06-edd3-482b-b220-bb066c5594f1","2024-02-15T21:04:55.264+00:00","2025-02-21T17:53:28.326+00:00",[],"Pentose-phosphate-pathway-disruption-in-the-pathogenesis-of-Parkinson-s-disease",{"abstract":1528,"title":1530,"references":1532,"doi":1534},{"EN":1529},"Oxidative stress is known to be a key factor in the pathogenesis of Parkinson’s disease (PD). Neuronal redox status is maintained by glucose metabolism via the pentose-phosphate pathway and it is known that disruption of glucose metabolism is damaging to neurons. Accumulating evidence supports the idea that glucose metabolism is altered in PD and dysregulation of the pentose-phosphate pathway in this disease has recently been shown. In this review, we present an overview of the literature regarding neuronal glucose metabolism and PD, and discuss the implications of these findings for PD pathogenesis and possible future therapeutic avenues.",{"EN":1531},"Pentose-phosphate pathway disruption in the pathogenesis of Parkinson’s disease",{"VOID":1533},"Healy D.G., Falchi M., O’Sullivan S.S., Bonifati V., Durr A., Bressman S., et al., Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson’s disease: a case-control study, Lancet Neurol., 2008, 7, 583–590\nSurmeier D.J., Guzman J.N., Sanchez-Padilla J., Goldberg J.A., The origins of oxidant stress in Parkinson’s disease and therapeutic strategies, Antioxid. Redox Signal., 2011, 14, 1289–1301\nHurtig H.I., Trojanowski J.Q., Galvin J., Ewbank D., Schmidt M.L., Lee V.M., et al., Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease, Neurology, 2000, 54, 1916–1921\nDias V., Junn E., Mouradian M.M., The role of oxidative stress in Parkinson’s disease, J. Parkinsons Dis., 2013, 3, 461–491\nAlam Z.I., Daniel S.E., Lees A.J., Marsden D.C., Jenner P., Halliwell B., A generalised increase in protein carbonyls in the brain in Parkinson’s but not incidental Lewy body disease, J. Neurochem., 1997, 69, 1326–1329\nJenner P., Oxidative stress in Parkinson’s disease, Ann. Neurol., 2003, 53(Suppl. 3), S26–S36, discussion S36–38\nBen-Yoseph O., Boxer P.A., Ross B.D., Oxidative stress in the central nervous system: monitoring the metabolic response using the pentose phosphate pathway, Dev. Neurosci., 1994, 16, 328–336\nSalvemini F., Franzé A., Iervolino A., Filosa S., Salzano S., Ursini M.V., Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression, J. Biol. Chem., 1999, 274, 2750–2757\nPandolfi P.P., Sonati F., Rivi R., Mason P., Grosveld F., Luzzatto L., Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress, EMBO J., 1995, 14, 5209–5215\nDunn L., Allen G.F., Mamais A., Ling H., Li A., Duberley K.E., et al., Dysregulation of glucose metabolism is an early event in sporadic Parkinson’s disease, Neurobiol. Aging, 2014, 35, 1111–1115\nBolanos J.P., Heales S.J., Persistent mitochondrial damage by nitric oxide and its derivatives: neuropathological implications, Front. Neuroenergetics, 2010, 2, 1\nHerrero-Mendez A., Almeida A., Fernández E., Maestre C., Moncada S., Bolaños J.P., The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\u002FC-Cdh1, Nat. Cell Biol., 2009, 11, 747–752\nPellerin L., Magistretti P.J., Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, Proc. Natl. Acad. Sci. USA, 1994, 91, 10625–10629\nTsacopoulos M., Magistretti P.J., Metabolic coupling between glia and neurons, J. Neurosci., 1996, 16, 877–885\nStokes A.H., Hastings T.G., Vrana K.E., Cytotoxic and genotoxic potential of dopamine, J. Neurosci. Res., 1999, 55, 659–665\nGraham D.G., Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones, Mol. Pharmacol., 1978, 14, 633–643\nHalliwell B., Gutteridge J.M., The importance of free radicals and catalytic metal ions in human diseases, Mol. Aspects Med., 1985, 8, 89–193\nDexter D.T., Wells F.R., Agid F., Agid Y., Lees A.J., Jenner P., et al., Increased nigral iron content in postmortem parkinsonian brain, Lancet, 1987, 2, 1219–1220\nJenner P., Olanow C.W., Oxidative stress and the pathogenesis of Parkinson’s disease, Neurology, 1996, 47(Suppl. 3), S161–170\nLangston J.W., Ballard P.A.Jr., Parkinson’s disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, N. Engl. J. Med., 1983, 309, 310\nRamsay R.R., Dadgar J., Trevor A., Singer T.P., Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP, Life Sci., 1986, 39, 581–588\nSchapira A.H., Cooper J.M., Dexter D., Jenner P., Clark J.B., Marsden C.D., Mitochondrial complex I deficiency in Parkinson’s disease, Lancet, 1989, 333, 1269\nBolaños J.P., Peuchen S., Heales S.J., Land J.M., Clark J.B., Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes, J. Neurochem., 1994, 63, 910–916\nMizuno Y., Ohta S., Tanaka M., Takamiya S., Suzuki K., Sato T., et al., Deficiencies in complex I subunits of the respiratory chain in Parkinson’s disease, Biochem. Biophys. Res. Commun., 1989, 163, 1450–1455\nLindroos M.M., Majamaa K., Tura A., Mari A., Kalliokoski K.K., Taittonen M.T., et al., m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction, Diabetes, 2009, 58, 543–549\nPowers W.J., Videen T.O., Markham J., Black K.J., Golchin N., Perlmutter J.S., Cerebral mitochondrial metabolism in early Parkinson’s disease, J. Cereb. Blood Flow Metab., 2008, 28, 1754–1760\nAlmeida A., Almeida J., Bolaños J.P., Moncada S., Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection, Proc. Natl. Acad. Sci. USA, 2001, 98, 15294–15299\nAlmeida A., Moncada S., Bolaños J.P., Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway, Nat. Cell Biol., 2004, 6, 45–51\nCohen S.S., Scott D.B., Gluconokinase and the oxidative path for glucose-6-phosphate utilization, Nature, 1950, 166, 781–782\nFilosa S., Fico A., Paglialunga F., Balestrieri M., Crooke A., Verde P., et al., Failure to increase glucose consumption through the pentosephosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress, Biochem. J., 2003, 370, 935–943\nBorghammer P., Perfusion and metabolism imaging studies in Parkinson’s disease, Dan. Med. J., 2012, 59, B4466\nDe Rosa A., Criscuolo C., Mancini P., De Martino M., Giordano I.A., Pappatà S., et al., Genetic screening for LRRK2 gene G2019S mutation in Parkinson’s disease patients from Southern Italy, Parkinsonism Relat. Disord., 2009, 15, 242–244\nVolonté M.A., Garibotto V., Spagnolo F., Panzacchi A., Picozzi P., Franzin A., et al., Changes in brain glucose metabolism in subthalamic nucleus deep brain stimulation for advanced Parkinson’s disease, Parkinsonism Relat. Disord., 2012, 18, 770–774\nHenchcliffe C., Shungu D.C., Mao X., Huang C., Nirenberg M.J., Jenkins B.G., et al., Multinuclear magnetic resonance spectroscopy for in vivo assessment of mitochondrial dysfunction in Parkinson’s disease, Ann. NY Acad. Sci., 2008, 1147, 206–220\nAhmed S.S., Santosh W., Kumar S., Christlet H.T., Metabolic profiling of Parkinson’s disease: evidence of biomarker from gene expression analysis and rapid neural network detection, J. Biomed. Sci., 2009, 16, 63\nZheng B., Liao Z., Locascio J.J., Lesniak K.A., Roderick S.S., Watt M.L., et al., PGC-1α, a potential therapeutic target for early intervention in Parkinson’s disease, Sci. Transl. Med., 2010, 2, 52ra73\nBassil F., Fernagut P.O., Bezard E., Meissner W.G., Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?, Prog. Neurobiol., 2014, 118C, 1–18\nHeales S.J., Davies S.E., Bates T.E., Clark J.B., Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration, Neurochem. Res., 1995, 20, 31–38\nHerken H., Neurotoxin-induced impairment of biopterin synthesis and function: initial stage of a Parkinson-like dopamine deficiency syndrome, Neurochem. Int., 1990, 17, 223–238\nSian J., Dexter D.T., Lees A.J., Daniel S., Agid Y., Javoy-Agid F., et al., Alterations in glutathione levels in Parkinson’s disease and other neurodegenerative disorders affecting basal ganglia, Ann. Neurol., 1994, 36, 348–355\nDexter D.T., Sian J., Rose S., Hindmarsh J.G., Mann V.M., Cooper J.M., et al., Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease, Ann. Neurol., 1994, 35, 38–44\nRussell R.L., Siedlak S.L., Raina A.K., Bautista J.M., Smith M.A., Perry G., Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease, Arch. Biochem. Biophys., 1999, 370, 236–239\nMartins R.N., Harper C.G., Stokes G.B., Masters C.L., Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer’s disease may reflect oxidative stress, J. Neurochem., 1986, 46, 1042–1045\nMeijer A.E., The pentose phosphate pathway in skeletal muscle under patho-physiological conditions. A combined histochemical and biochemical study, Prog. Histochem. Cytochem., 1991, 22, 1–118\nGupte S.A., Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases, Curr. Opin. Investig. Drugs, 2008, 9, 993–1000\nUrsini M.V., Parrella A., Rosa G., Salzano S., Martini G., Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress, Biochem. J., 1997, 323, 801–806\nNinfali P., Guidi L., Aluigi G., Biagiotti E., Del Grande P., High glucose-6-phosphate dehydrogenase activity contributes to the structural plasticity of periglomerular cells in the olfactory bulb of adult rats, Brain Res., 1999, 819, 150–154\nBraak H., Del Tredici K., Rüb U., de Vos R.A., Jansen Steur E.N., Braak E., Staging of brain pathology related to sporadic Parkinson’s disease, Neurobiol. Aging, 2003, 24, 197–211\nKirby J., Halligan E., Baptista M.J., Allen S., Heath P.R., Holden H., et al., Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS, Brain, 2005, 128, 1686–1706\nCosentino C., Grieco D., Costanzo V., ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair, EMBO J., 2011, 30, 546–555\nDavies P., Moualla D., Brown D.R., Alpha-synuclein is a cellular ferrireductase, PLoS One, 2011, 6, e15814\nBendor J.T., Logan T.P., Edwards R.H., The function of alpha-synuclein, Neuron, 2013, 79, 1044–1066\nBellucci A., Collo G., Sarnico I., Battistin L., Missale C., Spano P., Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2\u002FD3 receptor activation, J. Neurochem., 2008, 106, 560–577\nFornai F., Schlüter O.M., Lenzi P., Gesi M., Ruffoli R., Ferrucci M., et al., Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alphasynuclein, Proc. Natl. Acad. Sci. USA, 2005, 102, 3413–3418\nRodriguez-Araujo G., Nakagami H., Hayashi H., Mori M., Shiuchi T., Minokoshi Y., et al., Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1\u002FPI3K\u002FAkt transduction pathway, Cell. Mol. Life Sci., 2013, 70, 1123–1133\nLiberatore G.T., Jackson-Lewis V., Vukosavic S., Mandir A.S., Vila M., McAuliffe W.G., et al., Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease, Nat. Med., 1999, 5, 1403–1409\nFountaine T.M., Venda L.L., Warrick N., Christian H.C., Brundin P., Channon K.M., et al., The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons, Eur. J. Neurosci., 2008, 28, 2459–2473\nAdamczyk A., Czapski G.A., Kaźmierczak A., Strosznajder J.B., Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on alphasynuclein-evoked neuronal nitric oxide synthase activation in the rat brain, Pharmacol. Rep., 2009, 61, 1078–1085\nAdamczyk A., Kaźmierczak A., Czapski G.A., Strosznajder J.B., Alphasynuclein induced cell death in mouse hippocampal (HT22) cells is mediated by nitric oxide-dependent activation of caspase-3, FEBS Lett., 2010, 584, 3504–3508\nClancy R.M., Levartovsky D., Leszczynska-Piziak J., Yegudin J., Abramson S.B., Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary, Proc. Natl. Acad. Sci. USA, 1994, 91, 3680–3684\nBolaños J.P., Delgado-Esteban M., Herrero-Mendez A., Fernandez-Fernandez S., Almeida A., Regulation of glycolysis and pentosephosphate pathway by nitric oxide: impact on neuronal survival, Biochim. Biophys. Acta, 2008, 1777, 789–793\nMejías R., Villadiego J., Pintado C.O., Vime P.J., Gao L., Toledo-Aral J.J., et al., Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice, J. Neurosci., 2006, 26, 4500–4508\nOpperdoes F.R., Michels P.A., Enzymes of carbohydrate metabolism as potential drug targets, Int. J. Parasitol., 2001, 31, 482–490",{"VOID":1535},"10.2478\u002Fs13380-014-0221-y","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-014-0221-y\u002Fhtml",[1538,1553,1566,1579,1594],{"id":1539,"sortIndex":21,"researcher":20,"roles":1540,"affiliations":1541,"properties":1550,"displayName":1552,"givenName":20,"familyName":20},"026d23f2-9d0f-4d01-a298-5500c3056a0e",[133],[1542],{"id":1543,"sortIndex":21,"affiliation":1544,"properties":20},"0b8959a1-2ae3-4a7d-9f7a-3f790a6fbd97",{"id":1543,"createTime":20,"updateTime":20,"relativeEntities":1545,"slug":20,"properties":1546,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1549,"statistic":20},[],{"title":1547},{"VI":1548},"Undergraduate School of Medicine, Imperial College London, London, UK",[],{"title":1551},{"VI":1552},"Laura Dunn",{"id":1554,"sortIndex":104,"researcher":20,"roles":1555,"affiliations":1556,"properties":1563,"displayName":1565,"givenName":20,"familyName":20},"2fe06aca-93b7-4ce7-8e7e-d5f1aaba5ceb",[133],[1557],{"id":1543,"sortIndex":21,"affiliation":1558,"properties":20},{"id":1543,"createTime":20,"updateTime":20,"relativeEntities":1559,"slug":20,"properties":1560,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1562,"statistic":20},[],{"title":1561},{"VI":1548},[],{"title":1564},{"VI":1565},"Vanessa Fairfield",{"id":1567,"sortIndex":174,"researcher":20,"roles":1568,"affiliations":1569,"properties":1576,"displayName":1578,"givenName":20,"familyName":20},"38e28ed6-381d-4e21-bc5e-7985269ec516",[133],[1570],{"id":1543,"sortIndex":21,"affiliation":1571,"properties":20},{"id":1543,"createTime":20,"updateTime":20,"relativeEntities":1572,"slug":20,"properties":1573,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1575,"statistic":20},[],{"title":1574},{"VI":1548},[],{"title":1577},{"VI":1578},"Shanay Daham",{"id":1580,"sortIndex":200,"researcher":20,"roles":1581,"affiliations":1582,"properties":1591,"displayName":1593,"givenName":20,"familyName":20},"c4cbdf52-e7da-4101-82dd-c29fb353d50c",[133],[1583],{"id":1584,"sortIndex":21,"affiliation":1585,"properties":20},"d0b32b1f-530f-4b1c-85cc-fee0c7075f5b",{"id":1584,"createTime":20,"updateTime":20,"relativeEntities":1586,"slug":20,"properties":1587,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1590,"statistic":20},[],{"title":1588},{"VI":1589},"Institute of Functional Biology and Genomics, University of Salamanca — Consejo Superior de Investigaciones Científicas, Salamanca, Spain",[],{"title":1592},{"VI":1593},"Juan P. Bolaños",{"id":1595,"sortIndex":810,"researcher":20,"roles":1596,"affiliations":1597,"properties":1624,"displayName":1626,"givenName":20,"familyName":20},"fc0fa543-945f-4a09-9d67-e88f3bc5f6d2",[133],[1598,1606,1615],{"id":1599,"sortIndex":21,"affiliation":1600,"properties":20},"4183e529-e7d8-401b-afe5-717f93ca5120",{"id":1599,"createTime":20,"updateTime":20,"relativeEntities":1601,"slug":20,"properties":1602,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1605,"statistic":20},[],{"title":1603},{"VI":1604},"Chemical Pathology Department, Great Ormond Street Hospital, London, UK",[],{"id":1607,"sortIndex":104,"affiliation":1608,"properties":1614},"71498c4d-8d1c-475e-9eb7-f4bb0878bd5b",{"id":1607,"createTime":20,"updateTime":20,"relativeEntities":1609,"slug":20,"properties":1610,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1613,"statistic":20},[],{"title":1611},{"VI":1612},"Centre for Translational Genomics, University College London, Institute of Child Health, London, UK",[],{},{"id":1616,"sortIndex":174,"affiliation":1617,"properties":1623},"ddd96dbf-4f8f-4e5f-a1dc-483aff3fb607",{"id":1616,"createTime":20,"updateTime":20,"relativeEntities":1618,"slug":20,"properties":1619,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1622,"statistic":20},[],{"title":1620},{"VI":1621},"Department of Molecular Neuroscience, University College London, Institute of Neurology, Queen Square, London, UK",[],{},{"title":1625},{"VI":1626},"Simon J. Heales",{"url":1536,"publisher":1628,"properties":1670},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1629,"slug":10,"properties":1630,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1634,"manageAffiliations":1639,"indexDatabases":1650,"url":20,"thumbnailPath":20,"statistic":1665,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":1631,"title":1632,"eissn":1633},{"VOID":13},{"EN":15},{"VOID":17},[1635],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1636,"label":1637,"description":1638,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[1640,1645],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":1641,"slug":20,"properties":1642,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1644,"statistic":20},[],{"title":1643},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":1646,"slug":20,"properties":1647,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1649,"statistic":20},[],{"title":1648},{"EN":42},[],[1651,1658],{"id":46,"indexDatabase":1652,"url":57,"indexYears":58,"academicFieldIds":1657,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1653,"label":1654,"description":1655,"key":54,"publicationTags":1656,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":1659,"url":76,"indexYears":20,"academicFieldIds":1664,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":1660,"label":1661,"description":1662,"key":72,"publicationTags":1663,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":1666,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":1667,"totalCitation":93,"totalCitationByYear":1668,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":1669,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":1671,"volume":1673},{"VOID":1672},"179-184",{"VOID":267},"2014-08-15",[61,74],{"id":1677,"createTime":1678,"updateTime":1679,"relativeEntities":1680,"slug":1681,"properties":1682,"entityType":125,"verifyStatus":126,"verifyTime":1679,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1691,"fullTextUrl":20,"authors":1692,"publicationType":219,"publisherRelationship":1708,"citationCount":20,"citationInfo":20,"publishDate":940,"publishYear":395,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1755,"openAccess":20,"references":20,"isForceReanalyzing":271},"34be0471-d9af-48e3-b1b0-7773e4a10c30","2024-01-08T22:23:07.129+00:00","2025-02-20T21:15:37.990+00:00",[],"G-protein-co-signaling-and-challenges-for-translational-research",{"abstract":1683,"title":1685,"references":1687,"doi":1689},{"EN":1684},"The Gq-linked G protein coupled receptors (GPCRs) and their signaling pathways are important clinical targets for the dementia of Alzheimer’s disease and cognitive decline with aging. Gq stimulates phospholipase C-β1 (PLC-β1) activity, increasing levels of inositol-1, 4, 5-trisphosphate (IP3) and diacylglycerol, to initiate mobilization of intracellular Ca2+ and activation of protein kinase C, respectively. While high concentrations of ligand typically evoke large sustained increases in cytosolic Ca2+ levels, it has long been appreciated that the dynamics of the Ca2+ increase are more complex and consistent with multiple levels of regulation. Physiologically relevant concentrations of Gq-ligands evoke rhythmic fluctuations or an oscillation in the level of cytosolic Ca2+. Downstream targets are tuned to respond to the frequency of the Ca2+ oscillations which in turn, reflect the oscillations in IP3 levels. Oscillatory behavior depends on the assembly of self-organizing interactions. The components that contribute to and regulate the Ca2+ oscillator have been unclear, precluding transfer of this fundamental knowledge from bench to bedside. Many GPCRs that signal with Gq also co-signal with G12. G protein co-signaling could therefore regulate the Ca2+ oscillator. This letter explores the potential relationship between Ca2+ oscillations, G protein co-signaling and cellular response in the context of our recent observations. We found that Gq efficacy is synergistic with phosphatidic acid, (PA), a signaling mediator generated downstream of activated G12 and RhoA. Regulation by PA depends on interaction with the unique PLC-β1 PA binding region. G protein co-signaling is therefore a mechanism for GPCRs to collectively assemble self-organizing interactions that regulate the Ca2+ oscillator.",{"EN":1686},"G protein co-signaling and challenges for translational research",{"VOID":1688},"Wess J., Novel muscarinic receptor mutant mouse models, Handb. Exp. Pharmacol., 2012, 208, 95–117\nSchliebs R., Arendt T., The cholinergic system in aging and neuronal degeneration, Behav. Brain Res., 2011, 221, 555–563\nFisher A., Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer’s disease, J. Neurochem., 2012, 120, 22–33\nLitosch I., Novel mechanisms for feedback regulation of phospholipase C-β activity, IUBMB, 2002, 54, 253–260\nJope R. S., Song L., Li X., Powers R., Impaired phosphoinositide hydrolysis in Alzheimer’s disease brain, Neurobiol. Aging, 1994, 15, 221–226\nConn P. J., Christopoulos A., Lindsley C.W., Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders, Nat. Rev. Drug Discov., 2009, 8, 41–54\nGilman A. G., G-proteins: transducers of receptor-generated signals, Annu. Rev. Biochem., 1987, 56, 615–649\nBirnbaumer L., Expansion of signal transduction by G proteins, Biochim. Biophys. Acta., 2007, 1768, 772–793\nBerridge M. J., Calcium signaling remodeling and disease, Biochem. Soc. Trans., 2012, 40, 297–309\nMeyer T, Stryer L., Calcium spiking, Annu. Rev. Biophys. Biophys. Chem., 1991, 20, 153–174\nPoliti A., Gaspers L. D., Thomas A. P., Höfer T., Models of IP3 and Ca2+ oscillations: frequency encoding and identification of underlying feedbacks, Biophys. J., 2006, 90, 3120–3133\nHermans E., Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors, Pharmacol. Ther., 2003, 99, 25–44\nRiobo N. A., Manning D. R., Receptors coupled to heterotrimeric G proteins of the G12 family, Tds. Pharm. Sci., 2005, 26, 146–154\nLitosch I., Pujari R., Lee S. J., Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-β1, Cell. Signal., 2009, 21, 1379–1384\nLitosch I., Phosphatidic acid potentiates Gαq stimulation of phospholipase C-β1 signaling, Biochem. Biophys. Res. Commun., 2009, 390, 603–607\nDe Pittà M., Goldberg M., Volman V., Berry H., Ben-Jacob E., Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes, J. Biol. Phys., 2009, 35, 83–411\nTovey S.C., de Smet P., Lipp P., Thomas D., Young K.W., Missiaen L., et al, Calcium puffs are generic InsP3-activated elementary calcium signals and are down-regulated by prolonged hormonal stimulation to inhibit cellular calcium responses, J. Cell. Sci., 2001, 114, 3979–3989\nHarootunian A.T., Kao J.P., Paranjape S., Tsien R.Y., Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3, Science, 1991, 251, 75–78\nBartlett P.J., Young K.W., Nahorski S.R., Challiss R. A., Single cell analysis and temporal profiling of agonist-mediated inositol 1,4,5-trisphosphate, Ca2+, diacylglycerol, and protein kinase C signaling using fluorescent biosensors, J. Biol. Chem., 2005, 280, 21837–21846\nCodazzi F., Teruel M.N., Meyer T., Control of astrocyte Ca2+ oscillations and waves by oscillating translocation and activation of protein kinase C, Curr. Biol., 2001, 1, 1089–1097\nViolin J. D., Zhang J., Tsien R.Y., Newton A.C., A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C, J. Cell Biol., 2003, 161, 899–909\nEichwald C., Kaiser F., Model for receptor-controlled cytosolic calcium oscillations and for external influences on the signal pathway, Biophys. J., 1993, 65, 2047–2058\nRoss E. M., Coordinating speed and amplitude in G protein signaling, Curr. Biol., 2008, 18, R777–R783\nIlkaeva O., Kinch L.N., Paulssen R. H., Ross E. M., Mutations in the carboxyl-terminal domain of phospholipase C-β1 delineate the dimer interface and a potential Gαq interaction site, J. Biol. Chem., 2002, 277, 4294–4300\nLyon A. M., Tesmer V.M., Dhamsania V.D., Thal D.M., Gutierrez J., Chowdhury S., et al., An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gα(q) activation, Nat. Struct. Mol. Biol., 2011, 18, 999–1005\nTurcotte M., Ross E. M., Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP, PLoS Comput. Biol., 2008, 8, e1000148\nBiddlecome G.H., Berstein G., Ross E. M., Regulation of phospholipase C-β1 by Gq and m1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation, J. Biol. Chem., 1996, 271, 7999–8007\nLitosch I., RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy, Biochem. Biophys. Res. Commun., 2011, 415, 215–219\nFukaya M., Uchigashima M., Nomura S., Hasegawa Y., Kikuchi H., Watanabe M., Predominant expression of phospholipase C-β1 in telencephalic principal neurons and cerebellar interneurons, and its close association with related signaling molecules in somatodendritic neuronal elements, Eur. J. Neurosci., 2008, 28, 1744–1759\nNomura S., Fukaya M., Tsujioka T., Wu D., Watanabe M., Phospholipase C-β3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets, Eur. J. Neurosci., 2007, 25, 659–672\nKim D., Jun K.S., Lee S.B., Kang N.G., Min D.S., Kim Y.H., et al., Phospholipase C isozymes selectively couple to specific neurotransmitter receptors, Nat., 1997, 389, 290–293\nMcOmish C.E., Burrows E.L., Howard M., Hannan A.J., PLC-β1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression, Hippocamp., 2008, 18, 824–834\nKurian M.A., Meyer E., Vassallo G., Morgan N.V., Prakash N., Pasha S., et al., Phospholipase C β1 deficiency is associated with early-onset epileptic encephalopathy, Brain, 2010, 133, 2964–2970\nRoss E. M., Mateu D., Gomes A. V., Arana C., Tran T., Litosch I., Structural determinants for phosphatidic acid regulation of phospholipase-C β1, J. Biol. Chem., 2006, 281, 33087–33094\nLitosch I., Regulation of phospholipase C-β1 activity by phosphatidic acid, Biochem., 2000, 39, 7736–7743\nLitosch I, Regulation of phospholipase C-β activity by phosphatidic acid: isoform dependence, role of protein kinase C, and G protein subunits, Biochem., 2003, 42, 1618–1623\nJenkins G. M., Frohman, M. A., Phospholipase D: a lipid centric review, Cell Mol. Life Sci., 2005, 62, 2306–2316\nShulga Y.V., Topham M.K., Epand R.M., Regulation and functions of diacylglycerol kinases, Chem. Rev., 2011, 111, 6186–6208\nRaghu P., Manifava M., Coadwell J., Ktistakis N.T., Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors), Biochim. Biophys. Acta, 2009, 1791, 889–897\nLemmon M. A., Membrane recognition by phospholipid-binding domains, Nat. Rev. Mol. Cell Biol., 2008, 9, 99–111\nTesterink C., Larsen P.B., van der Does D., van Himbergen J.A.J., Munnik T., Phosphatidic acid binds to and inhibits the activity of Arabidopsis CTR1, J. Exp. Bot., 2007, 58, 3905–3914\nSmrcka A.V., Brown J.H., Holz G.G., Role of phospholipase C-ɛ in physiological phosphoinositide signaling networks, Cell. Signal., 2012, 24, 1333–1343\nMurthy S.N., Chung P.H., Lin L., Lomasney J.W., Activation of phospholipase C-ɛ by free fatty acids and cross talk with phospholipase D and phospholipase A2, Biochem., 2006, 45, 10987–10997\nWu D., Tadano M., Edamatsu H., Masago-Toda M., Yamawaki-Kataoka Y., Terashima T., et al., Neuronal lineage-specific induction of phospholipase C-ɛ expression in the developing mouse brain, Eur. J. Neurosci., 2003, 17, 1571–1580\nKelley G.G., Kaproth-Joslin K.A., Reks S.E., Smrcka A.V., Wojcikiewicz R.J., G-protein-coupled receptor agonists activate endogenous phospholipase C-ɛ and phospholipase C-β3 in a temporally distinct manner, J. Biol. Chem., 2006, 281, 2639–2648\nLitosch I., Protein kinase C inhibits the Ca2+-dependent stimulation of phospholipase C-β1 in vitro. Recept. Signal. Transduct., 1996, 6, 87–98\nLitosch I., G-protein βγ subunits antagonize protein kinase C-dependent phosphorylation and inhibition of phospholipase C-β1, Biochem. J., 1997, 326, 701–707\nYue C., Ku C.Y., Liu M., Simon M.I., Sanborn B.M., Molecular mechanism of the inhibition of phospholipase C-β3 by protein kinase C, J. Biol. Chem., 2000, 275, 30220–30225\nPhilip F., Kadamur G., Silos R.G., Woodson J., Ross E.M., Synergistic activation of phospholipase C-β3 by Gαq and Gβγ describes a simple two-state coincidence detector, Curr. Biol., 2010, 20, 1327–1335\nRosse C., Linch M., Kermorgant S., Cameron A.J., Boeckeler K., Parker P.J., PKC and the control of localized signal dynamics, Nat. Rev. Mol. Cell Biol., 2010, 11, 103–112\nNewton A.C., Protein kinase C: poised to signal, Am. J. Physiol. Endocrinol. Metab., 2010, 298, E395–E402\nReither G., Schaefer M., Lipp P., PKCα: a versatile key for decoding the cellular calcium toolkit, J. Cell Biol., 2006, 174, 521–533\nMarignani P.A., Epand R.M., Sebaldt R.J., Acyl chain dependence of diacylglycerol activation of protein kinase C activity in vitro, Biochem. Biophys. Res. Commun., 1996, 225, 469–473\nSinger W.D., Brown H. A., Jiang X., Sternweis P.C., Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity, J. Biol. Chem., 1996, 271, 4504–4510\nYue C., Dodge K.L., Weber G., Sanborn B.M., Phosphorylation of serine 1105 by protein kinase A inhibits phospholipase C-β3 stimulation by Gαq, J. Biol. Chem., 1998, 273, 18023–18027\nLitosch I., Negative feedback regulation of Gq signaling by protein kinase C is disrupted by diacylglycerol kinase ζ in COS-7 cells, Biochem. Biophys. Res. Commun., 2012, 417, 956–960\nLuo B., Prescott S.M., Topham M. K., Protein kinase C phosphorylates and negatively regulates diacylglycerol kinase ζ, J. Biol. Chem., 2003, 278, 39542–39547\nBaranovichi H., Hogan A.B., Obagi C., Topham M.K., Gee S.H., Diacylglycerol kinase ζ localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins, Mol. Biol. Cell, 2003, 14, 4499–4511",{"VOID":1690},"10.2478\u002Fs13380-013-0102-9","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fs13380-013-0102-9\u002Fhtml",[1693],{"id":1694,"sortIndex":21,"researcher":20,"roles":1695,"affiliations":1696,"properties":1705,"displayName":1707,"givenName":20,"familyName":20},"04911983-b055-4ebd-af4a-23f8f83a73ff",[133],[1697],{"id":1698,"sortIndex":21,"affiliation":1699,"properties":20},"08ae11f4-6cb2-4951-a29e-341cd604a4c1",{"id":1698,"createTime":20,"updateTime":20,"relativeEntities":1700,"slug":20,"properties":1701,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1704,"statistic":20},[],{"title":1702},{"VI":1703},"Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, USA",[],{"title":1706},{"VI":1707},"Irene Litosch",{"url":1691,"publisher":1709,"properties":1751},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1710,"slug":10,"properties":1711,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1715,"manageAffiliations":1720,"indexDatabases":1731,"url":20,"thumbnailPath":20,"statistic":1746,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":1712,"title":1713,"eissn":1714},{"VOID":13},{"EN":15},{"VOID":17},[1716],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1717,"label":1718,"description":1719,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[1721,1726],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":1722,"slug":20,"properties":1723,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1725,"statistic":20},[],{"title":1724},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":1727,"slug":20,"properties":1728,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1730,"statistic":20},[],{"title":1729},{"EN":42},[],[1732,1739],{"id":46,"indexDatabase":1733,"url":57,"indexYears":58,"academicFieldIds":1738,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1734,"label":1735,"description":1736,"key":54,"publicationTags":1737,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":1740,"url":76,"indexYears":20,"academicFieldIds":1745,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":1741,"label":1742,"description":1743,"key":72,"publicationTags":1744,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":1747,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":1748,"totalCitation":93,"totalCitationByYear":1749,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":1750,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":1752,"volume":1754},{"VOID":1753},"66-73",{"VOID":939},[61,74],{"id":1757,"createTime":1758,"updateTime":1759,"relativeEntities":1760,"slug":1761,"properties":1762,"entityType":125,"verifyStatus":126,"verifyTime":1759,"verifyNote":127,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1771,"fullTextUrl":20,"authors":1772,"publicationType":219,"publisherRelationship":1862,"citationCount":20,"citationInfo":20,"publishDate":1910,"publishYear":1463,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":1911,"openAccess":20,"references":20,"isForceReanalyzing":271},"7e83ceb0-7a9c-427c-b0fa-191719910fb2","2023-12-26T00:16:26.597+00:00","2025-02-19T17:42:12.585+00:00",[],"Cingulum-bundle-white-matter-in-MAG-knockout-mice",{"abstract":1763,"title":1765,"references":1767,"doi":1769},{"EN":1764},"Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia.",{"EN":1766},"Cingulum bundle white matter in MAG-knockout mice",{"VOID":1768},"Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D. et al., Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia, Proc Natl Acad Sci U S A, 2001; 98, 4746–4751\nTkachev D., Mimmack M.L., Ryan M.M., Wayland M., Freeman T., Jones P.B. et al., Oligodendrocyte dysfunction in schizophrenia and bipolar disorder, Lancet, 2003; 362, 798–805\nWan C., Yang Y., Feng G., Gu N., Liu H., Zhu S. et al., Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population, Neurosci Lett, 2005; 388, 126–131\nHof P.R., Haroutunian V., Friedrich V.L., Jr., Byne W., Buitron C., Perl D.P. et al., Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia, Biol Psychiatry, 2003; 53, 1075–1085\nUranova N.A., Vostrikov V.M., Orlovskaya D.D., Rachmanova V.I., Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium, Schizophr Res, 2004; 67, 269–275\nUranova N., Orlovskaya D., Vikhreva O., Zimina I., Kolomeets N., Vostrikov V. et al., Electron microscopy of oligodendroglia in severe mental illness, Brain Res Bull, 2001; 55, 597–610\nArnone D., McIntosh A.M., Tan G.M., Ebmeier K.P., Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia, Schizophr Res, 2008, 101, 124–132\nHighley J.R., Esiri M.M., McDonald B., Cortina-Borja M., Herron B.M., Crow T.J., The size and fibre composition of the corpus callosum with respect to gender and schizophrenia: a post-mortem study, Brain, 1999; 122(Pt 1), 99–110\nBuchsbaum M.S., Friedman J., Buchsbaum B.R., Chu K.W., Hazlett E.A., Newmark R. et al., Diffusion tensor imaging in schizophrenia, Biol Psychiatry, 2006; 60, 1181–1187\nBuchsbaum M.S., Tang C.Y., Peled S., Gudbjartsson H., Lu D., Hazlett E.A. et al., MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia, NeuroReport, 1998; 9, 425–430\nHoptman M.J., Ardekani B.A., Butler P.D., Nierenberg J., Javitt D.C., Lim K.O., DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis, NeuroReport, 2004; 15, 2467–2470\nKubicki M., McCarley R., Westin C.F., Park H.J., Maier S., Kikinis R. et al., A review of diffusion tensor imaging studies in schizophrenia, J Psychiatr Res, 2007; 41, 15–30\nKubicki M., Park H., Westin C.F., Nestor P.G., Mulkern R.V., Maier S.E. et al., DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity, Neuroimage, 2005; 26, 1109–1118\nLim K.O., Hedehus M., Moseley M., de Crespigny A., Sullivan E.V., Pfefferbaum A., Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging, Arch Gen Psychiatry, 1999; 56, 367–374\nMiyata J., Hirao K., Namiki C., Fukuyama H., Okada T., Miki Y. et al., Interfrontal commissural abnormality in schizophrenia: tractography-assisted callosal parcellation, Schizophr Res, 2007; 97, 236–241\nShergill S.S., Kanaan R.A., Chitnis X.A., O’Daly O., Jones D.K., Frangou S. et al., A diffusion tensor imaging study of fasciculi in schizophrenia, Am J Psychiatry, 2007; 164, 467–473\nBenes F.M., Emerging principles of altered neural circuitry in schizophrenia, Brain Res Rev, 2000; 31, 251–269\nSelemon L.D., Goldman-Rakic P.S., The reduced neuropil hypothesis: a circuit based model of schizophrenia, Biol Psychiatry, 1999; 45, 17–25\nDevinsky O., Morrell M.J., Vogt B.A., Contributions of anterior cingulate cortex to behaviour, Brain, 1995; 118(Pt 1), 279–306\nDracheva S., Davis K.L., Chin B., Woo D.A., Schmeidler J., Haroutunian V., Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients, Neurobiol Dis, 2006; 21, 531–540\nKatsel P., Davis K.L., Haroutunian V., Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study, Schizophr Res, 2005; 79, 157–173\nMcCullumsmith R.E., Gupta D., Beneyto M., Kreger E., Haroutunian V., Davis K.L. et al., Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia, Schizophr Res, 2007; 90, 15–27\nStark A.K., Uylings H.B., Sanz-Arigita E., Pakkenberg B., Glial cell loss in the anterior cingulate cortex, a subregion of the prefrontal cortex, in subjects with schizophrenia, Am J Psychiatry, 2004; 161, 882–888\nYakovlev P.I., Locke S., Limbic nuclei of thalamus and connections of limbic cortex. III. Corticocortical connections of the anterior cingulate gyrus, the cingulum, and the subcallosal bundle in monkey, Arch Neurol, 1961; 5, 364–400\nSchmahmann J.D., Pandya D.N., Wang R., Dai G., D’Arceuil H.E., de Crespigny A.J. et al., Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography, Brain, 2007; 130, 630–653\nKubicki M., Westin C.F., Nestor P.G., Wible C.G., Frumin M., Maier S.E. et al., Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study, Biol Psychiatry, 2003; 54, 1171–1180\nSun Z., Wang F., Cui L., Breeze J., Du X., Wang X. et al., Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study, NeuroReport, 2003; 14, 1833–1836\nWang F., Sun Z., Cui L., Du X., Wang X., Zhang H. et al., Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging, Am J Psychiatry, 2004; 161, 573–575\nFujiwara H., Namiki C., Hirao K., Miyata J., Shimizu M., Fukuyama H. et al., Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: a diffusion tensor imaging study, Schizophr Res, 2007; 95, 215–222\nSegal D., Haznedar M.M., Hazlett E.A., Entis J.J., Newmark R.E., Torosjan Y. et al., Diffusion tensor anisotropy in the cingulate gyrus in schizophrenia, Neuroimage, 2010; 50, 357–365\nKumra S., Ashtari M., Cervellione K.L., Henderson I., Kester H., Roofeh D. et al., White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study, J Am Acad Child Adolesc Psychiatry, 2005; 44, 934–941\nWhite T., Cullen K., Rohrer L.M., Karatekin C., Luciana M., Schmidt M. et al., Limbic structures and networks in children and adolescents with schizophrenia, Schizophr Bull, 2008; 34, 18–29\nLi C., Tropak M.B., Gerlai R., Clapoff S., Abramow-Newerly W., Trapp B. et al., Myelination in the absence of myelin-associated glycoprotein, Nature, 1994; 369, 747–750\nLoers G., Aboul-Enein F., Bartsch U., Lassmann H., Schachner M., Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study, Mol Cell Neurosci, 2004; 27, 175–189\nWeiss M.D., Hammer J., Quarles R.H., Oligodendrocytes in aging mice lacking myelin-associated glycoprotein are dystrophic but not apoptotic, J Neurosci Res, 2000; 62, 772–780\nWeiss M.D., Luciano C.A., Quarles R.H., Nerve conduction abnormalities in aging mice deficient for myelin-associated glycoprotein, Muscle Nerve, 2001; 24, 1380–1387\nMontag D., Giese K.P., Bartsch U., Martini R., Lang Y., Bluthmann H. et al., Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin, Neuron, 1994; 13, 229–246\nPan B., Fromholt S.E., Hess E.J., Crawford T.O., Griffin J.W., Sheikh K.A. et al., Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice, Exp Neurol, 2005; 195, 208–217\nQuarles R.H., A hypothesis about the relationship of myelinassociated glycoprotein’s function in myelinated axons to its capacity to inhibit neurite outgrowth, Neurochem Res, 2009; 34, 79–86\nHoistad M., Segal D., Takahashi N., Sakurai T., Buxbaum J.D., Hof P.R., Linking white and grey matter in schizophrenia: oligodendrocyte and neuron pathology in the prefrontal cortex, Front Neuroanat, 2009; 3, 9\nZhang J., van Zijl P.C., Mori S., Three-dimensional diffusion tensor magnetic resonance microimaging of adult mouse brain and hippocampus, Neuroimage, 2002; 15, 892–901\nHof P.R., Young W.G., Bloom F.E., Belichenko P.V., Celio M.R. Comparative Cytoarchitectonic Atlas of the C57BL\u002F6 and 129\u002FSv Mouse Brains. Amsterdam: Elsevier; 2000.\nSchmued L., Slikker W., Jr., Black-gold: a simple, high-resolution histochemical label for normal and pathological myelin in brain tissue sections, Brain Res, 1999; 837, 289–297\nCalhoun M.E., Mouton P.R., Length measurement: new developments in neurostereology and 3D imagery, J Chem Neuroanat, 2001; 21, 257–265\nKreczmanski P., Schmidt-Kastner R., Heinsen H., Steinbusch H.W., Hof P.R., Schmitz C., Stereological studies of capillary length density in the frontal cortex of schizophrenics, Acta Neuropathol, 2005; 109, 510–518\nMouton P.R., Gokhale A.M., Ward N.L., West M.J., Stereological length estimation using spherical probes, J Microsc, 2002; 206, 54–64\nSchmitz C., Hof P.R., Design-based stereology in neuroscience, Neuroscience, 2005; 130, 813–831\nSchmitz C., Grolms N., Hof P.R., Boehringer R., Glaser J., Korr H., Altered spatial arrangement of layer V pyramidal cells in the mouse brain following prenatal low-dose X-irradiation. A stereological study using a novel three-dimensional analysis method to estimate the nearest neighbor distance distributions of cells in thick sections, Cereb Cortex, 2002; 12, 954–960\nDavis K.L., Stewart D.G., Friedman J.I., Buchsbaum M., Harvey P.D., Hof P.R. et al., White matter changes in schizophrenia: evidence for myelin-related dysfunction, Arch Gen Psychiatry, 2003; 60, 443–456\nKubicki M., McCarley R.W., Shenton M.E., Evidence for white matter abnormalities in schizophrenia, Curr Opin Psychiatry, 2005; 18, 121–134\nHighley J.R., Esiri M.M., McDonald B., Roberts H.C., Walker M.A., Crow T.J., The size and fiber composition of the anterior commissure with respect to gender and schizophrenia, Biol Psychiatry, 1999; au]45, 1120–1127\nChance S.A., Highley J.R., Esiri M.M., Crow T.J., Fiber content of the fornix in schizophrenia: lack of evidence for a primary limbic encephalopathy, Am J Psychiatry, 1999; 156, 1720–1724\nMarner L., Pakkenberg B., Total length of nerve fibers in prefrontal and global white matter of chronic schizophrenics, J Psychiatr Res, 2003; 37, 539–547\nHighley J.R., Walker M.A., Esiri M.M., Crow T.J., Harrison P.J., Asymmetry of the uncinate fasciculus: a post-mortem study of normal subjects and patients with schizophrenia, Cereb Cortex, 2002; 12, 1218–1224\nCasanova M.F., Zito M., Bigelow L.B., Berthot B., Sanders R.D., Kleinman J.E., Axonal counts of the corpus callosum of schizophrenic patients, J Neuropsychiatry Clin Neurosci, 1989; 1, 391–393\nNasrallah H.A., McCalley-Whitters M., Bigelow L.B., Rauscher F.P., A histological study of the corpus callosum in chronic schizophrenia, Psychiatry Res, 1983; 8, 251–260\nSegal D., Schmitz C., Hof P.R., Spatial distribution and density of oligodendrocytes in the cingulum bundle are unaltered in schizophrenia, Acta Neuropathol, 2009; 117, 385–394\nPeters A., The effects of normal aging on myelin and nerve fibers: a review, J Neurocytol, 2002; 31, 581–593\nVoineskos A.N., Lobaugh N.J., Bouix S., Rajji T.K., Miranda D., Kennedy J.L. et al., Diffusion tensor tractography findings in schizophrenia across the adult lifespan, Brain, 2010; 133, 1494–1504\nKaufman J.A., Ahrens E.T., Laidlaw D.H., Zhang S., Allman J.M., Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, Primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion-tensor imaging, Anat Rec, 2005; 287A, 1026–1037",{"VOID":1770},"10.2478\u002Fv10134-010-0019-6","https:\u002F\u002Fwww.degruyter.com\u002Fdocument\u002Fdoi\u002F10.2478\u002Fv10134-010-0019-6\u002Fhtml",[1773,1788,1802,1815,1830,1850],{"id":1774,"sortIndex":21,"researcher":20,"roles":1775,"affiliations":1776,"properties":1785,"displayName":1787,"givenName":20,"familyName":20},"5f0e046b-3088-420c-be93-54753448f74d",[133],[1777],{"id":1778,"sortIndex":21,"affiliation":1779,"properties":20},"fd93c366-27a4-4ef3-97d7-2cdcfa95f4a8",{"id":1778,"createTime":20,"updateTime":20,"relativeEntities":1780,"slug":20,"properties":1781,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1784,"statistic":20},[],{"title":1782},{"VI":1783},"Departments of Neuroscience, Mount Sinai School of Medicine, New York, USA",[],{"title":1786},{"VI":1787},"Devorah Segal",{"id":1789,"sortIndex":104,"researcher":20,"roles":1790,"affiliations":1791,"properties":1800,"displayName":1064,"givenName":20,"familyName":20},"9edbf5c8-24d1-442c-a5b4-8d8e96924044",[133],[1792],{"id":1793,"sortIndex":21,"affiliation":1794,"properties":20},"f4cee8eb-b801-4554-a018-26a2886ffc2d",{"id":1793,"createTime":20,"updateTime":20,"relativeEntities":1795,"slug":20,"properties":1796,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1799,"statistic":20},[],{"title":1797},{"VI":1798},"Departments of Radiology, Mount Sinai School of Medicine, New York, USA",[],{"title":1801},{"VI":1064},{"id":1803,"sortIndex":174,"researcher":20,"roles":1804,"affiliations":1805,"properties":1812,"displayName":1814,"givenName":20,"familyName":20},"42a66269-b2e8-4432-8c5f-014c5d52a1f4",[133],[1806],{"id":1778,"sortIndex":21,"affiliation":1807,"properties":20},{"id":1778,"createTime":20,"updateTime":20,"relativeEntities":1808,"slug":20,"properties":1809,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1811,"statistic":20},[],{"title":1810},{"VI":1783},[],{"title":1813},{"VI":1814},"Malin Höistad",{"id":1816,"sortIndex":200,"researcher":20,"roles":1817,"affiliations":1818,"properties":1827,"displayName":1829,"givenName":20,"familyName":20},"5ba95924-f72f-47b6-8f76-2d83e33b15c4",[133],[1819],{"id":1820,"sortIndex":21,"affiliation":1821,"properties":20},"86114bbd-e9c1-497f-875a-e370cbe5a2a9",{"id":1820,"createTime":20,"updateTime":20,"relativeEntities":1822,"slug":20,"properties":1823,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1826,"statistic":20},[],{"title":1824},{"VI":1825},"Departments of Psychiatry, Mount Sinai School of Medicine, New York, USA",[],{"title":1828},{"VI":1829},"Vahram Haroutunian",{"id":1831,"sortIndex":810,"researcher":20,"roles":1832,"affiliations":1833,"properties":1847,"displayName":1849,"givenName":20,"familyName":20},"7f46004b-b3c1-4ad0-b7c1-88653407c34a",[133],[1834,1840],{"id":1793,"sortIndex":21,"affiliation":1835,"properties":20},{"id":1793,"createTime":20,"updateTime":20,"relativeEntities":1836,"slug":20,"properties":1837,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1839,"statistic":20},[],{"title":1838},{"VI":1798},[],{"id":1820,"sortIndex":104,"affiliation":1841,"properties":1846},{"id":1820,"createTime":20,"updateTime":20,"relativeEntities":1842,"slug":20,"properties":1843,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1845,"statistic":20},[],{"title":1844},{"VI":1825},[],{},{"title":1848},{"VI":1849},"Cheuk Y. Tang",{"id":1851,"sortIndex":397,"researcher":20,"roles":1852,"affiliations":1853,"properties":1860,"displayName":851,"givenName":20,"familyName":20},"86c2dac1-a6de-4f6e-99dd-bb11f55c078b",[133],[1854],{"id":1778,"sortIndex":21,"affiliation":1855,"properties":20},{"id":1778,"createTime":20,"updateTime":20,"relativeEntities":1856,"slug":20,"properties":1857,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1859,"statistic":20},[],{"title":1858},{"VI":1783},[],{"title":1861},{"VI":851},{"url":1771,"publisher":1863,"properties":1905},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1864,"slug":10,"properties":1865,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1869,"manageAffiliations":1874,"indexDatabases":1885,"url":20,"thumbnailPath":20,"statistic":1900,"gsStatistic":20,"type":20,"analyzePriority":20},[],{"issn":1866,"title":1867,"eissn":1868},{"VOID":13},{"EN":15},{"VOID":17},[1870],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":1871,"label":1872,"description":1873,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},[1875,1880],{"id":31,"createTime":20,"updateTime":20,"relativeEntities":1876,"slug":20,"properties":1877,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1879,"statistic":20},[],{"title":1878},{"EN":35},[],{"id":38,"createTime":20,"updateTime":20,"relativeEntities":1881,"slug":20,"properties":1882,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1884,"statistic":20},[],{"title":1883},{"EN":42},[],[1886,1893],{"id":46,"indexDatabase":1887,"url":57,"indexYears":58,"academicFieldIds":1892,"indexDatabaseRanking":61},{"id":48,"createTime":20,"updateTime":20,"relativeEntities":1888,"label":1889,"description":1890,"key":54,"publicationTags":1891,"standard":20},[],{"EN":51,"VI":51},{"EN":51,"VI":53},[56],[60],{"id":63,"indexDatabase":1894,"url":76,"indexYears":20,"academicFieldIds":1899,"indexDatabaseRanking":20},{"id":65,"createTime":20,"updateTime":20,"relativeEntities":1895,"label":1896,"description":1897,"key":72,"publicationTags":1898,"standard":20},[],{"EN":68,"VI":68},{"EN":70,"VI":71},[74,75],[78],{"impactFactor":21,"impactFactorByYear":1901,"i10Index":86,"i10IndexLast5Year":21,"totalPublication":87,"totalPublicationByYear":1902,"totalCitation":93,"totalCitationByYear":1903,"totalCitationPerPublication":98,"totalCitationPerPublicationByYear":1904,"hindexLast5Year":105,"hindex":105},{"2012":81,"2013":82,"2014":83,"2015":84,"2016":85},{"2010":89,"2011":90,"2012":90,"2013":91,"2014":92},{"2010":92,"2011":95,"2012":96,"2013":97,"2014":92},{"2010":100,"2011":101,"2012":102,"2013":103,"2014":104},{"pages":1906,"volume":1908},{"VOID":1907},"131-138",{"VOID":1909},"1","2010-10-22",[61,74]]