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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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in several regions of HCV genome are shown to correlate with response to interferon (IFN) treatment. Persistence of HCV infection and poor susceptibility to treatment might be contributed by mutations arising within HCV genome which enable the virus to escape from host immune response\u002FIFN treatment. This study investigated mutations in core and NS5A genes of HCV from non-responder and relapser patients after treatment with Peg-IFN-α and ribavirin. Viral RNA was extracted from patient sera and core and NS5A genes were amplified by RT-PCR. Nucleotide sequences of the core and NS5A genes were determined by direct sequencing, and converted to amino acid sequences. Nucleotide and amino acid sequences in the core region, ISDR, PKRBD, and V3 regions within NS5A after treatment were highly conserved when comparing to their corresponding sequences obtained before treatment. Interestingly, when comparing the virus from relapsers to those from non-responders, the number of mutations after treatment in N-terminal region of NS5A of virus from relapsers was significantly higher than those from non-responders (P \u003C 0.05). Amino acid mutations at the N-terminus of NS5A of the virus in relapsers might help the virus to survive and somehow relapse after the cessation of the treatment.",{"EN":946},"Analysis of mutations in the core and NS5A genes of hepatitis C virus in non-responder and relapser patients after treatment with Peg-IFN-α and ribavirin",{"VOID":948},"Akuta N, Suzuki F, Sezaki H, et al. Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy. Intervirology. 2005;48(6):372–80.\nCastillo I, Rodriguez-Inigo E, Bartolome J, et al. Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection. Gut. 2005;54(5):682–5.\nCuevas JM, Torres-Puente M, Jimenez-Hernandez N, et al. Refined analysis of genetic variability parameters in hepatitis C virus and the ability to predict antiviral treatment response. J Viral Hepat. 2008;15(8):578–90.\nEnomoto N, Sakuma I, Asahina Y, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med. 1996;334(2):77–81.\nEscudero A, Rodriguez F, Serra MA, Del Olmo JA, Montes F, Rodrigo JM. Pegylated alpha-interferon-2a plus ribavirin compared with pegylated alpha-interferon-2b plus ribavirin for initial treatment of chronic hepatitis C virus: prospective, non-randomized study. J Gastroenterol Hepatol. 2008;23(6):861–6.\nFried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 2002;347(13):975–82.\nGale MJ Jr, Korth MJ, Tang NM, et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology. 1997;230(2):217–27.\nGale MJ Jr, Korth MJ, Katze MG. Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance. Clin Diagn Virol. 1998;10(2–3):157–62.\nGerotto M, Dal Pero F, Sullivan DG, et al. Evidence for sequence selection within the non-structural 5A gene of hepatitis C virus type 1b during unsuccessful treatment with interferon-alpha. J Viral Hepat. 1999;6(5):367–72.\nGong GZ, Lai LY, Jiang YF, He Y, Su XS. HCV replication in PBMC and its influence on interferon therapy. World J Gastroenterol. 2003;9(2):291–4.\nHayashi K, Katano Y, Ishigami M, et al. Mutations in the core and NS5A region of hepatitis C virus genotype 1b and correlation with response to pegylated-interferon-alpha 2b and ribavirin combination therapy. J Viral Hepat. 2011;18(4):280–6.\nHofmann WP, Zeuzem S, Sarrazin C. Hepatitis C virus-related resistance mechanisms to interferon alpha-based antiviral therapy. J Clin Virol. 2005;32(2):86–91.\nJanuszkiewicz-Lewandowska D, Wysocki J, Pernak M, et al. Presence of hepatitis C virus (HCV)-RNA in peripheral blood mononuclear cells in HCV serum negative patients during interferon and ribavirin therapy. Jpn J Infect Dis. 2007;60(1):29–32.\nKumthip K, Pantip C, Chusri P, et al. Correlation between mutations in the core and NS5A genes of hepatitis C virus genotypes 1a, 1b, 3a, 3b, 6f and the response to pegylated interferon and ribavirin combination therapy. J Viral Hepat. 2011;18(4):e117–25.\nKumthip K, Chusri P, Pantip C, et al. Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy. J Med Virol. 2014;86(8):1360–5.\nMarrone A, Sallie R. Genetic heterogeneity of hepatitis C virus. The clinical significance of genotypes and quasispecies behavior. Clin Lab Med. 1996;16(2):429–49.\nMartell M, Esteban JI, Quer J, et al. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J Virol. 1992;66(5):3225–9.\nMunoz de Rueda P, Casado J, Paton R, et al. Mutations in E2-PePHD, NS5A-PKRBD, NS5A-ISDR, and NS5A-V3 of hepatitis C virus genotype 1 and their relationships to pegylated interferon-ribavirin treatment responses. J Virol. 2008;82(13):6644–53.\nNousbaum J, Polyak SJ, Ray SC, et al. Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy. J Virol. 2000;74(19):9028–38.\nOkanoue T, Itoh Y, Hashimoto H, et al. Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study. J Gastroenterol. 2009;44(9):952–63.\nPawlotsky JM, Germanidis G, Neumann AU, Pellerin M, Frainais PO, Dhumeaux D. Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations. J Virol. 1998;2(4):2795–805.\nReed KE, Rice CM. Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Curr Top Microbiol Immunol. 2000;242:55–84.\nTai AW, Chung RT. Treatment failure in hepatitis C: mechanisms of non-response. J Hepatol. 2009;50(2):412–20.\nTaliani G, Badolato C, Lecce R, et al. Hepatitis C virus RNA in peripheral blood mononuclear cells: relation with response to interferon treatment. J Med Virol. 1995;47(1):16–22.\nTellinghuisen TL, Marcotrigiano J, Rice CM. Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature. 2005;435(7040):374–9.\nTellinghuisen TL, Foss KL, Treadaway J. Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog. 2008;4(3):e1000032.\nTong CY, Gilmore IT, Hart CA. HCV-associated liver cancer. Lancet. 1995;345(8956):1058–9.\nTorres-Puente M, Cuevas JM, Jimenez-Hernandez N, et al. Genetic variability in hepatitis C virus and its role in antiviral treatment response. J Viral Hepat. 2008;15(3):188–99.\nWang JT, Sheu JC, Lin JT, Wang TH, Chen DS. Detection of replicative form of hepatitis C virus RNA in peripheral blood mononuclear cells. J Infect Dis. 1992;166(5):1167–9.\nWohnsland A, Hofmann WP, Sarrazin C. Viral determinants of resistance to treatment in patients with hepatitis C. Clin Microbiol Rev. 2007;20(1):23–38.",{"VOID":950},"10.1007\u002Fs13337-015-0300-x","PUBLICATION","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13337-015-0300-x",[955,971,984,999,1014,1027],{"id":956,"sortIndex":32,"researcher":28,"roles":957,"affiliations":959,"properties":968,"displayName":970,"givenName":28,"familyName":28},"88f1e6e1-31a9-4612-bed3-ab7b32dee053",[958],"AUTHOR",[960],{"id":961,"sortIndex":32,"affiliation":962,"properties":28},"e40da25b-b70f-4eb6-843d-b5739ddb9617",{"id":961,"createTime":28,"updateTime":28,"relativeEntities":963,"slug":28,"properties":964,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":967,"statistic":28},[],{"title":965},{"VI":966},"Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand",[],{"title":969},{"VI":970},"Kattareeya 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viral agent of the porcine epidemic diarrhea (PED) was investigated during the reported 2014–2015 outbreaks in commercial farms in Central Luzon, Philippines. The study covered detection of PED virus (PEDV) in fecal and intestinal samples through reverse transcription PCR and sequence analysis of the nucleocapsid (N) gene. Results showed that 10 out of 34 fecal and intestinal samples examined were positive for PEDV. The partial nucleotide sequence of the N gene of the field samples showed 98–99% homologous to PEDV sequences registered in the GenBank. It was also noted that N gene sequences between field samples were 98% homologous. Interestingly, the partial sequences of the N genes of the field samples were genetically similar to the PEDV isolates from USA, China, Mexico, Canada and Japan. The phylogenetic tree analysis revealed that the Philippine samples clustered in group 2–1 of the PEDV, wherein the isolates of this group were responsible for the outbreaks in Asia and the USA. Analysis of the partial nucleotide and amino acid sequences revealed polymorphisms, deletions and insertions in the N-gene of the PEDV. Amino acid sequence alignment also showed deletions and insertion in the PEDV detected in the Philippines.",{"EN":1095},"Characterisation of porcine epidemic diarrhea virus isolates during the 2014–2015 outbreak in the Philippines",{"VOID":1097},"Song DS, Oh JS, Kang BK, Yang JS, Song JY, Moon HJ, Kim TY, Yoo HS, Jang YS, Park BK. Fecal shedding of a highly cell-culture-adapted porcine epidemic virus after oral inoculation in pigs. J Swine Health Prod. 2005;13(5):269–72.\nWang S, Cheng X, Chen S, Lin F, Jiang B, Zhu X, Li Z, Wang J, Chen S. Classification of emergent US strain of PED virus by phylogenetic analysis of nucleocapsid and ORF3 genes. J Clin Microbiol. 2014;52(9):3509–10.\nLee C. Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus. Virol J. 2015;12:93.\nToplak I, Ipavec M, Kuhar U, Kusar D, Papic B, Koren S, Toplak N. Complete genome sequence of the porcine epidemic diarrhea strain SLO\u002FJH-11\u002F2015. Genome Announc. 2016;4(2):e01725-15.\nParaguison-Alili R, Domigo CYJ. Phylogenetic tracking of current porcine epidemic diarrhea virus (PEDV) strains in the Philippines. Arch Virol. 2016;161(9):2601–4.\nTeenavechyan S, Frantz PN, Wongthida P, Chailangkarn T, Jaru-ampornpan P, Koonpaew S, Jongkaewwattana A. Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse genetics. Virus Res. 2016;226:152–71.\nWood EN. An apparently new syndrome of porcine epidemic diarrhea. Vet Rec. 1977;100:243–4.\nPensaert MB, de Bouck P. A new coronavirus-like particle associated with diarrhea in swine. Arch Virol. 1978;50:243–7.\nTurgeon DC, Morin M, Jolette J, Higgins R, Marsolais G, Di Franco E. Coronavirus-like particles associated with diarrhea in baby pigs in Quebec. Can Vet J. 1980;21:100–23.\nFan H, Zhang J, Ye Y, Tong T, Xie K, Lao M. Complete genome sequence of novel porcine epidemic diarrhea virus in South China. 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Complete genome sequence of K14J1301, a novel variant strain of porcine epidemic diarrhea virus in South Korea. Genome Announc. 2014;2(3):e00505-14.\nLee S, Park GS, Shin JH, Lee C. Full-genome sequence analysis of variant strain of porcine epidemic diarrhea virus in South Korea. Genome Announc. 2014;2(6):e01116-14.\nCheun-Arom T, Temeeyasen G, Srijangwad A, Tripipat T, Sangmalee S, Vui T, Chusana T, Tantituvanoat A, Nilubol D. Complete genome sequence of two genetically distinct variants of porcine epidemic diarrhea virus in the Eastern Region of Thailand. Genome Announc. 2015;3(3):e00634-15.\nStott CJ, Wiratsudakul A, Temeeyasen G, Sawattrakool K, Nilubol D. An introduction of porcine epidemic diarrhea virus to Thailand. Thai J Vet Med Suppl. 2016;46:369–70.\nDuy DT, Toan NT, Puranaveja S, Thanawongnuwech R. Genetic characterization of porcine epidemic diarrhea virus (PEDV) isolates from Southern Vietnam during 2009–2010 outbreaks. 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J Virol Methods. 2016;234:137–41.\nDiel DG, Lawson S, Okda F, Singrey A, Clement T, Fernandes MHV, Christopher-Hennings J, Nelson EA. Porcine epidemic diarrhea virus: an overview of current virological and serological diagnostic methods. Virus Res. 2016;226:60–70.",{"VOID":1099},"10.1007\u002Fs13337-018-0470-4","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs13337-018-0470-4",[1102,1117,1130,1145,1158,1173],{"id":1103,"sortIndex":32,"researcher":28,"roles":1104,"affiliations":1105,"properties":1114,"displayName":1116,"givenName":28,"familyName":28},"ec7da2f2-252e-4123-9ee7-6815e1b38bf3",[958],[1106],{"id":1107,"sortIndex":32,"affiliation":1108,"properties":28},"d35ee302-20ba-4227-800a-83735209eb3b",{"id":1107,"createTime":28,"updateTime":28,"relativeEntities":1109,"slug":28,"properties":1110,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1113,"statistic":28},[],{"title":1111},{"VI":1112},"College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz, Philippines",[],{"title":1115},{"VI":1116},"Gemerlyn G. Garcia",{"id":1118,"sortIndex":40,"researcher":28,"roles":1119,"affiliations":1120,"properties":1127,"displayName":1129,"givenName":28,"familyName":28},"9db1ce56-3378-4d88-8b08-54a89490cb31",[958],[1121],{"id":1107,"sortIndex":32,"affiliation":1122,"properties":28},{"id":1107,"createTime":28,"updateTime":28,"relativeEntities":1123,"slug":28,"properties":1124,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1126,"statistic":28},[],{"title":1125},{"VI":1112},[],{"title":1128},{"VI":1129},"Mark Arman D. 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Balbin",{"id":1146,"sortIndex":42,"researcher":28,"roles":1147,"affiliations":1148,"properties":1155,"displayName":1157,"givenName":28,"familyName":28},"f74d9791-a0b8-466b-8473-558a53304a5e",[958],[1149],{"id":1135,"sortIndex":32,"affiliation":1150,"properties":28},{"id":1135,"createTime":28,"updateTime":28,"relativeEntities":1151,"slug":28,"properties":1152,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1154,"statistic":28},[],{"title":1153},{"VI":1140},[],{"title":1156},{"VI":1157},"Lawrence P. Belotindos",{"id":1159,"sortIndex":45,"researcher":28,"roles":1160,"affiliations":1161,"properties":1170,"displayName":1172,"givenName":28,"familyName":28},"e0081192-be0b-4520-8c39-7204b43ddb9a",[958],[1162],{"id":1163,"sortIndex":32,"affiliation":1164,"properties":28},"a8ad948e-3f00-4c1c-9611-81f70d51b4dc",{"id":1163,"createTime":28,"updateTime":28,"relativeEntities":1165,"slug":28,"properties":1166,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1169,"statistic":28},[],{"title":1167},{"VI":1168},"Angeles Core Enterprise Inc., Angeles City, Philippines",[],{"title":1171},{"VI":1172},"Jonathan G. Supnet",{"id":1174,"sortIndex":46,"researcher":28,"roles":1175,"affiliations":1176,"properties":1192,"displayName":1194,"givenName":28,"familyName":28},"fea3731e-58c7-4171-9db7-5bff473cf612",[958],[1177,1183],{"id":1135,"sortIndex":32,"affiliation":1178,"properties":28},{"id":1135,"createTime":28,"updateTime":28,"relativeEntities":1179,"slug":28,"properties":1180,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1182,"statistic":28},[],{"title":1181},{"VI":1140},[],{"id":1184,"sortIndex":40,"affiliation":1185,"properties":1191},"2b7995b9-f291-495a-9bf8-d723a9127807",{"id":1184,"createTime":28,"updateTime":28,"relativeEntities":1186,"slug":28,"properties":1187,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1190,"statistic":28},[],{"title":1188},{"VI":1189},"Department of Animal Science, College of Agriculture, Central Luzon State University, Science City of Muñoz, Philippines",[],{},{"title":1193},{"VI":1194},"Claro N. Mingala",{"url":1100,"publisher":1196,"properties":1230},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1197,"slug":872,"properties":1198,"entityType":25,"verifyStatus":881,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1202,"manageAffiliations":1211,"indexDatabases":1217,"url":28,"thumbnailPath":28,"statistic":1225,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1199,"title":1200,"eissn":1201},{"VOID":877},{"EN":872},{"VOID":875},[1203,1207],{"id":884,"createTime":28,"updateTime":28,"relativeEntities":1204,"label":1205,"description":1206,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":887},{},{"id":890,"createTime":28,"updateTime":28,"relativeEntities":1208,"label":1209,"description":1210,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":893},{},[1212],{"id":897,"createTime":28,"updateTime":28,"relativeEntities":1213,"slug":28,"properties":1214,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1216,"statistic":28},[],{"title":1215},{"EN":901},[903],[1218],{"id":906,"indexDatabase":1219,"url":912,"indexYears":913,"academicFieldIds":1224,"indexDatabaseRanking":917},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1220,"label":1221,"description":1222,"key":781,"publicationTags":1223,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[915,916],{"impactFactor":32,"impactFactorByYear":1226,"i10Index":136,"i10IndexLast5Year":49,"totalPublication":920,"totalPublicationByYear":1227,"totalCitation":922,"totalCitationByYear":1228,"totalCitationPerPublication":925,"totalCitationPerPublicationByYear":1229,"hindexLast5Year":126,"hindex":126},{"2015":316,"2016":52,"2017":169,"2018":194,"2019":194,"2020":319,"2021":286,"2022":709,"2023":52},{"2013":145,"2014":139,"2015":69,"2016":353,"2017":150,"2018":208,"2019":139,"2020":436,"2021":611,"2022":69,"2023":150,"2024":42},{"2014":924,"2015":159,"2016":159,"2017":611,"2018":324,"2019":148,"2020":830,"2021":147,"2022":131,"2023":123},{"2014":927,"2015":183,"2016":588,"2017":928,"2018":442,"2019":929,"2020":930,"2021":229,"2022":931,"2023":106},{"pages":1231,"volume":1233},{"VOID":1232},"342-348",{"VOID":1234},"29","2018-06-28",2018,[917],{"id":1239,"createTime":1240,"updateTime":1241,"relativeEntities":1242,"slug":1243,"properties":1244,"entityType":951,"verifyStatus":26,"verifyTime":1241,"verifyNote":952,"languages":28,"translateLanguages":28,"viewCount":40,"primaryUrl":1253,"fullTextUrl":28,"authors":1254,"publicationType":1040,"publisherRelationship":1311,"citationCount":28,"citationInfo":28,"publishDate":1351,"publishYear":1352,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":1353,"openAccess":28,"references":28,"isForceReanalyzing":1084},"03342335-6aa0-41d7-a008-8431cf8324e7","2024-01-04T11:21:16.690+00:00","2025-01-22T12:32:26.156+00:00",[],"Neutralizing-antibody-response-against-subcutaneously-injected-bacteriophages-in-rabbit-model",{"abstract":1245,"title":1247,"references":1249,"doi":1251},{"EN":1246},"Bacteriophage therapy is currently experiencing a renaissance. Therapeutic efficacy of bacteriophages depends on phage-bacterial and phage-host interactions. The appearance of neutralizing anti-phage antibody has been speculated to be one of the few reasons for bacteriophage therapy's failure. This study aimed to know whether there is a rise in the neutralizing antibody on the parenteral injection of bacteriophages in an animal model. This study included bacteriophages against five different bacteria, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella Typhi and Staphylococcus aureus. These bacteriophages were isolated, propagated and purified. Bacteriophage specificity was confirmed by spot testing on the respective bacterial lawn. Weekly subcutaneous injection of purified bacteriophages (109PFU) was given to five rabbits for six weeks. Blood samples were collected before administering the next dose every week. The antibody response was tested by phage neutralization followed by plaque assay by using double agar overlay method. The rise in anti-phage neutralizing antibodies was observed usually after the 3rd week after immunization. Complete neutralization of bacteriophages could be seen between 3 and 5 weeks after immunization. A further rise in bacteriophage counts (PFU), especially on 1:1000 and 1:2000 serum dilutions, could be noticed by the end of 6th week against most bacteriophages injected. Background anti-phage neutralizing antibodies were observed against bacteriophage specific to Escherichia coli. However, it was absent against bacteriophages specific to other four bacteria. Bacteriophage interacts with mammalian host and induces anti-phages neutralizing antibody production. However, neutralization of phage depends on repeated administration and duration of therapy. The significant rise in neutralizing antibody could be seen at the end of 3rd week. Therefore, bacteriophage can be effectively used in acute cases where therapy duration is less than 2 weeks. However, for prolonged therapy, bacteriophage cocktail of different antigenicity may be suggested.",{"EN":1248},"Neutralizing antibody response against subcutaneously injected bacteriophages in rabbit model",{"VOID":1250},"Belinda L, Sebastian L. A call for a multidisciplinary future of phage therapy to combat multi-drug resistant bacterial infections. Infect Microbe Dis. 2020;2:1–2. https:\u002F\u002Fdoi.org\u002F10.1097\u002FIM9.0000000000000018.\nZumla A, Rao M, Wallis RS, Kaufmann SH, Rustomjee R, Mwaba P, et al. Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. Lancet Infect Dis. 2016;16(4):e47–63. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1473-3099(16)00078-5.\nSybesma W, Pimay JP. Expert round table on acceptance and re-implementation of bacteriophage therapy. 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Viruses. 2019;11:10.\nKrut O, Bekeredjian-Ding I. Contribution of the immune response to phage therapy. J Immunol. 2018;200(9):3037–44.\nUhr JW, Finkelstein MS. Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunological memory to bacteriophage phi-X 174. J Exp Med. 1963;117:457–77.\nUhr JW, Finkelstein MS, Baumann JB. Antibody formation. III. The primary and secondary antibody response to bacteriophage phi X 174 in guinea pigs. J Exp Med. 1962;115:655–70.\nHa’jek P. Neutralization of bacterial viruses by antibodies of young animals. The development of the avidity of 19S and 7S neutralizing antibodies in the course of primary and secondary response in young rabbits immunized with PhiX 174 bacteriophage. Folia Microbiol (Praha). 1970;15:9–16.\nStashak PW, Baker PJ, Roberso BS. The serum antibody response to bacteriophage phi chi 174 in germ-free and conventionally reared mice. I. Assay of neutralizing antibody by a 50 per cent neutralization method. Immunol. 1970;18:295–305.\nWang B, Hu B, Xu M, Yan Q, Liu S, Zhu X, Sun Z, Reed R, Ding L, Gong J, Li QQ, Hu J. Use of bacteriophage in the treatment of experimental animal bacteremia from imipenem-resistant Pseudomonas aeruginosa. Int J Mol Med. 2006;17:309–17.\nWang B, Hu B, Xu M, Yan Q, Liu S, Zhu X, Sun Z, Reed R, Ding L, Gong J, Li QQ, Hu J. Therapeutic effectiveness of bacteriophages in the rescue of mice with extended-spectrum beta-lactamase-producing Escherichia coli bacteremia. Int J Mol Med. 2006;17:347–55.\nBiswas B, Adhya S, Washart P, Paul B, Trostel AN, Powel B, Carlton R, Merril CR. Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium. Infect Immun. 2002;70:204–10.\nŻaczek M, Łusiak-Szelachowska M, Jończyk-Matysiak E, Weber-Dąbrowska B, Międzybrodzki R, Owczarek B, Kopciuch A, Fortuna W, Rogóż P, Górski A. Antibody production in response to Staphylococcal MS-1 phage cocktail in patients undergoing phage therapy. Front Microbiol. 2016;7:1681. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmicb.2016.01681.\nSingla S, Harjai K, Katare OP, Chhibber S. Encapsulation of bacteriophage in liposome accentuates its entry into macrophage and shields it from neutralizing antibodies. PLoS ONE. 2016;11:e0153777.\nAdams MH. Bacteriophages. New York and London: Inter-science Publishers; 1959.\nKropinski AM, Mazzocco A, Waddell TE, Lingohr E, Johnson RP. Enumeration of bacteriophages by double agar overlay plaque assay. In: Bacteriophages, 2009; pp. 69–76. Humana Press.\nŁusiak-Szelachowska M, Żaczek M, Weber-Dąbrowska B, Miedzybrodzki R, Klak M, Fortuna W, et al. Phage neutralization by sera of patients receiving phage therapy. Viral immunol. 2014;27(6):295–304.\nMajewska J, Beta W, Lecion D, Hodyra-Stefaniak K, Kłopot A, Kaźmierczak Z, et al. Oral application of T4 phage induces weak antibody production in the gut and in the blood. Viruses. 2015;7(8):4783–99. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fv7082845.\nDąbrowska K, Miernikiewicz P, Piotrowicz A, Hodyra K, Owczarek B, Lecion D, Mierczak ZK, Letarov A, Gorski A. Immunogenicity studies of proteins forming the T4 phage head surface. J Virol. 2014;88(21):12551–7.\nGenovese MC, Covarrubias A, Leon G, Mysler E, Keiserman M, Valente R, et al. Subcutaneous abatacept versus intravenous abatacept: a phase IIIb noninferiority study in patients with an inadequate response to methotrexate. Arthritis Rheum. 2011;63(10):2854–64.",{"VOID":1252},"10.1007\u002Fs13337-021-00673-8","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13337-021-00673-8",[1255,1270,1285,1298],{"id":1256,"sortIndex":32,"researcher":28,"roles":1257,"affiliations":1258,"properties":1267,"displayName":1269,"givenName":28,"familyName":28},"7d2762ef-dd07-440c-9781-9674bb4935e1",[958],[1259],{"id":1260,"sortIndex":32,"affiliation":1261,"properties":28},"0e0b0318-2dbc-4296-af8a-45b3d5bada90",{"id":1260,"createTime":28,"updateTime":28,"relativeEntities":1262,"slug":28,"properties":1263,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1266,"statistic":28},[],{"title":1264},{"VI":1265},"Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India",[],{"title":1268},{"VI":1269},"Archana Archana",{"id":1271,"sortIndex":40,"researcher":28,"roles":1272,"affiliations":1273,"properties":1282,"displayName":1284,"givenName":28,"familyName":28},"9f7e054b-64ba-4178-9b13-bab36ed856bb",[958],[1274],{"id":1275,"sortIndex":32,"affiliation":1276,"properties":28},"ec6aecfe-ec4b-4e23-846d-1ce5b067017c",{"id":1275,"createTime":28,"updateTime":28,"relativeEntities":1277,"slug":28,"properties":1278,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1281,"statistic":28},[],{"title":1279},{"VI":1280},"Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India",[],{"title":1283},{"VI":1284},"Prem Shankar 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emerging or re-emerging infections are posing continuous threat to both public health system and clinical care globally. The emergence of infections especially caused by arboviruses can be linked to several mechanisms which include geographical expansion linked to human development and transportation, global warming, enhanced transmission in peridomestic area and close proximity of human habitations to domestic as well as wild animals. The co-circulation of Dengue, Chikungunya and Zika is a matter of public health priority due to the fact that they are transmitted by the same vector as well as increase in the number of reported cases of severe dengue, post-chikungunya chronic joint disease and microcephaly related to Zika virus disease. The study was designed to estimate the prevalence of these arboviral infections in Odisha. About 5198 cases presenting with common clinical symptoms of fever, arthralgia, headache, myalgia and malaise were screened during 2016–2019. A total of 42.2% patients tested positive for dengue NS1 antigen (n = 4154), 30.2% for dengue IgM (n = 2161) and 14.3% for chikungunya IgM (n = 1816). A total of 1684 samples were subjected to Zika RT-PCR and none was tested positive. Peak in the numbers of dengue\u002F chikungunya cases was evident in the post-monsoon months of July – October. Circulation of all four serotypes of dengue i.e. DEN 1, 2, 3, and 4 was noticed in the state. Molecular investigation of suspected Chik cases in early phases showed circulation of Eastern Central Southern African genotype (E1:226A). There is dearth of knowledge about disease severity during arbovirus co-infections and importance of adequate management of patients at an early stage residing in risk areas. It is the first study in Odisha to study the pattern and status of these three arboviral diseases Dengue, Chikungunya and Zika. The outcome of this study will help in focusing and improvement of existing surveillance systems and vector control tools, as well as on the development of suitable antiviral agents and formulating candidate vaccine.",{"EN":1364},"Prevalence and trend of emerging and re-emerging arboviral infections in the state of Odisha",{"VOID":1366},"World Health Organization. Dengue: guidelines for diagnoses, treatment, prevention and control. Geneva: WHO; 2009.\nBurt FJ, Rolph MS, Rulli NE, et al. Chikungunya: a re-emerging virus. Lancet. 2012;379(662–71):2.\nCenters for Disease Control and Protection. Chikungunya: Information for Healthcare Providers. Available at: http:\u002F\u002Fwww.cdc.gov\u002Fchikungunya\u002Fpdfs\u002FCHIKV_Clinicians.pdf. Accessed April 10, 2016.\nGulland A. Zika virus is a global public health emergency, declares WHO. BMJ. 2016:i657.\nPatterson J, Sammon M, Garg M. Dengue, Zika and Chikungunya: emerging arboviruses in the new world. West J Emerg Med. 2016;17(6):671–9. https:\u002F\u002Fdoi.org\u002F10.5811\u002Fwestjem.2016.9.30904.\nIoos S, Mallet HP, Leparc Goffart I, et al. Current Zika virus epidemiology and recent epidemics. Med Mal Infect. 2014;44:302–7.\nLanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol. 1992;30(3):545–51.\nPfeffer M, Linssen B, Parker MD, Kinney RM. Specific detection of chikungunya virus using a RT-PCR\u002Fnested PCR combination. J Vet Med B Infect Dis Vet Public Health. 2002;49(1):49–54.\nDas B, Sahu A, Das M, Patra A, Dwibedi B, Kar SK, Hazra RK. Molecular investigations of chikungunya virus during outbreaks in Orissa, Eastern India in 2010. Infect Genet Evol. 2012;12(5):1094–101. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.meegid.2012.03.012.\nBeltrán-Silva SL, et al. 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Indian J Med Res. 2011;133(3):316–21.\nGupta E, Dar L, Narang P, Srivastava VK, Barror S. Serodiagnosis of dengue during an outbreak at a tertiary hospital in Delhi. Indian J Med Res. 2005;121:36–8.\nShashi SS, et al. Serosurveillance of Dengue. Chikungunya and Zika in Jammu, a Sub-Himalayan Region of India, J Clin Diagn Res. 2017;11(11):DC05–8.\nKurukumbi M, Wali JP, Broor S, Aggarwal P, Seth P, Handa R, et al. Seroepidemiology and active surveillance of dengue fever\u002Fdengue haemorrhagic fever in Delhi. Indian J Med Sci. 2001;55(3):149–56.\nParida MM, Dash PK, Upadhyay C, Saxena JAM. Serological and virological investigation of an Outbreak of Dengue fever in Gwalior, India. Indian J Med Res. 2002;116:248–54.\nPialoux G, Gaüzère BA, Jauréguiberry S, Strobel M. Chikungunya: an epidemic arbovirosis. Lancet Infect Dis. 2007;7:319–27.\nNational Vector Borne Disease Control Programme. Chikungunya fever. 2017; http:\u002F\u002Fnvbdcp.gov.in\u002Fchikun-status.html. Accessed 24 May 2017.\nFuruya-Kanamori L, Liang S, Milinovich G, Magalhaes RJS, Clements ACA, Hu W, et al. Co-distribution and co-infection of chikungunya and dengue viruses. BMC Infect Dis. 2016;16:84.\nSingh J, Dinkar A, Singh RG, Siddiqui MS, Sinha N, Singh SK. Clinical profile of dengue fever and coinfection with chikungunya. Ci Ji Yi Xue Za Zhi. 2018;30(3):158–64. https:\u002F\u002Fdoi.org\u002F10.4103\u002Ftcmj.tcmj_138_17.\nSippy R, Herrera D, Gaus D, Gangnon RE, Patz JA, Osorio JE. Seasonal patterns of dengue fever in rural Ecuador: 2009–2016. PLoS Negl Trop Dis. 2019;13(5): e0007360. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pntd.0007360.\nKakarla SG, Caminade C, Mutheneni SR, et al. Lag effect of climatic variables on dengue burden in India. Epidemiol Infect. 2019;147: e170. https:\u002F\u002Fdoi.org\u002F10.1017\u002FS0950268819000608.\nGaneshkumar P, Murhekar MV, Poornima V, Saravanakumar V, Sukumaran K, Anandaselvasankar A, et al. Dengue infection in India: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2018;12(7): e0006618. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pntd.0006618.\nBroor S, Devi LS. Arboviral Infections in India. Indian J Health Sci Care. 2015;2(3):192–202.\nLiang G, Gao X, Gould EA. Factors responsible for the emergence of arboviruses; strategies, challenges and limitations for their control. Emerg Microbes Infect. 2015;4(3): e18. https:\u002F\u002Fdoi.org\u002F10.1038\u002Femi.2015.18.\nKilpatrick AM, Randolph SE. Drivers, dynamics, and control of emerging vector-borne zoonotic diseases. Lancet. 2012;380:1946–55.\nChowell G, Cazelles B, Broutin H, Munayco CV. The influence of geographic and climate factors on the timing of dengue epidemics in Perú, 1994–2008. BMC Infect Dis. 2011;11:164. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1471-2334-11-164.\nCardoso CW, Paploski IA, Kikuti M, et al. Outbreak of Exanthematous Illness Associated with Zika, Chikungunya, and Dengue Viruses, Salvador, Brazil. Emerg Infect Dis. 2015;21(12):2274–6. https:\u002F\u002Fdoi.org\u002F10.3201\u002Feid2112.151167.\nAzeredo EL, dos Santos FB, Barbosa LS, Souza TMA, Badolato-Corrêa J, Sánchez-Arcila JC, Nunes PCG, de-Oliveira-Pinto LM, de Filippis AM, Dal Fabbro M, Hoscher Romanholi I, Venancio da Cunha R. Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil. PLOS Currents Outbreaks. 2018 Feb 15. Edition 1. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fcurrents.outbreaks.0bf6aeb4d30824de63c4d5d745b217f5.\nSolomon T, Dung N, Vaughn D, Kneen R, Thao L, Raengsakulrach B, et al. Neurological manifestations of dengue infection. Lancet. 2000;355:1053–8.\nCenters for Disease Control and Prevention. Clinical Guidance Dengue Virus. http:\u002F\u002Fwww.cdc.gov\u002Fdengue\u002FclinicalLab\u002Fclinical.html. Accessed 30 Mar 2016.\nMishra B, Turuk J, Sahu SJ, Khajuria A, Kumar S, Dey A, Praharaj AK. Co-circulation of all four dengue virus serotypes: first report from Odisha. Indian J Med Microbiol. 2017;35:293–5.",{"VOID":1368},"10.1007\u002Fs13337-021-00730-2","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs13337-021-00730-2",[1371,1386,1399,1414,1427,1440,1453,1466,1479,1492],{"id":1372,"sortIndex":32,"researcher":28,"roles":1373,"affiliations":1374,"properties":1383,"displayName":1385,"givenName":28,"familyName":28},"f24f0cdc-cca8-4053-8d38-21a36ac7528d",[958],[1375],{"id":1376,"sortIndex":32,"affiliation":1377,"properties":28},"b13f04be-0830-4971-bf7d-c365daeab633",{"id":1376,"createTime":28,"updateTime":28,"relativeEntities":1378,"slug":28,"properties":1379,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1382,"statistic":28},[],{"title":1380},{"VI":1381},"Virus Research and Diagnostic Laboratory, ICMR – Regional Medical Research Centre, Bhubaneswar, India",[],{"title":1384},{"VI":1385},"Subhra 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astrovirus (BAstV) is a small single-stranded RNA virus, which belongs taxonomically to genus Mamastrovirus under the family Astroviridae. The BAstV is strongly linked to neonatal diarrhea of calves. A few studies are available on BAstV, mainly from Asia, and to a lesser extent from Europe, South America, and Africa. There is only one report from Egypt, in which BAstV was found in diarrheic calves, either in single- or co-infections, based on reverse transcription polymerase chain reaction (RT-PCR) and BAstV-polymerase enzyme targeting primers. One of the samples was further subjected to genomic characterization using Illumina platform for next generation sequencing (NGS). After being processed, the returned BAstV complete genome was subjected to sequence and phylogenetic analysis in comparison to reference strains. The BAstV open reading frames (ORF1a, ORF1b, and ORF2) followed a nearly similar genetic topology, as they belonged to the same unclassified lineage, which was earlier proposed as BAstV-lineage 1, and is known to be disseminated worldwide. This close phylogenetic relationship between the study strain and other members of this lineage was further confirmed by high nucleotide and amino acid (aa) identities. Additionally, a total of 24 unique aa residues were found through the entire BAstV genome. As being the first report in Egypt, indeed Africa, we believe that this record shall be useful in either taxonomic classification or epidemiological tracking of BAstV. The status of BAstV in Egypt should be carefully investigated with possible to-be-implemented precautions for the protection of animal-raising industries.",{"EN":1556},"Genomic features of first bovine astrovirus detected in Egypt",{"VOID":1558},"Alfred N, Liu H, Li M, Hong S, Tang H, Wei Z, Chen Y, Li F, Zhong Y, Huang W. Molecular epidemiology and phylogenetic analysis of diverse bovine astroviruses associated with diarrhea in cattle and water buffalo calves in China. J Vet Med Sci. 2015;77:643–51. https:\u002F\u002Fdoi.org\u002F10.1292\u002Fjvms.14-0252.\nBoros Á, Albert M, Pankovics P, Bíró H, Pesavento PA, Phan TG, Delwart E, Reuter G. Outbreaks of neuroinvasive astrovirus associated with encephalomyelitis, weakness, and paralysis among weaned pigs, Hungary. Emerg Infect Dis. 2017;23:1982–93. https:\u002F\u002Fdoi.org\u002F10.3201\u002Feid2312.170804.\nBosch A, Guix S, Krishna NK, Méndez E, Monroe SS, Pantin-Jackwood M, Schultz-Cherry S. Family Astroviridae. In: King AMQ, Lefkowitz E, Adams MJ, Carstens EB, editors. Virus taxonomy: classification and nomenclature of viruses (ninth report of the international committee on the taxonomy of viruses). New York: Elsevier Academic Press; 2011. p. 953–9.\nBoujon CL, Koch MC, Wüthrich D, Werder S, Jakupovic D, Bruggmann R, Seuberlich T. Indication of cross-species transmission of astrovirus associated with encephalitis in sheep and cattle. Emerg Infect Dis. 2017;23:1604–6. https:\u002F\u002Fdoi.org\u002F10.3201\u002Feid2309.170168.\nBridger JC, Hall GA, Brown JF. Characterization of a calici-like virus (Newbury agent) found in association with astrovirus in bovine diarrhea. Infect Immun. 1984;43:133–8.\nCandido M, Alencar AL, Almeida-Queiroz SR, Buzinaro Mda G, Munin FS, de Godoy SH, Livonesi MC, Fernandes AM, de Sousa RL. Molecular detection and phylogenetic analysis of bovine astrovirus in Brazil. Arch Virol. 2015;160:1519–25. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00705-015-2400-8.\nCastells M, Bertoni E, Caffarena RD, Casaux ML, Schild C, Victoria M, Correa FR, Giannitti F, Parreño V, Colina R. Bovine astrovirus surveillance in Uruguay reveals high detection rate of a novel Mamastrovirus species. Viruses. 2020;12:32. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fv12010032.\nDe Benedictis P, Schultz-Cherry S, Burnham A, Cattoli G. Astrovirus infections in humans and animals—molecular biology, genetic diversity, and interspecies transmissions. Infect Genet Evol. 2011;11:1529–44. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.meegid.2011.07.024.\nDonato C, Vijaykrishna D. The broad host range and genetic diversity of mammalian and avian astroviruses. Viruses. 2017;9:102. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fv9050102.\nFu Y, Pan M, Wang X, Xu Y, Xie X, Knowles NJ, Yang H, Zhang D. Complete sequence of a duck astrovirus associated with fatal hepatitis in ducklings. J Gen Virol. 2009;90:1104–8. https:\u002F\u002Fdoi.org\u002F10.1099\u002Fvir.0.008599-0.\nImada T, Yamaguchi S, Mase M, Tsukamoto K, Kubo M, Morooka A. Avian nephritis virus (ANV) as a new member of the family Astroviridae and construction of infectious ANV cDNA. J Virol. 2000;74:8487–93. https:\u002F\u002Fdoi.org\u002F10.1128\u002Fjvi.74.18.8487-8493.2000.\nKumar S, Stecher G, Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol. 2016;33:1870–4. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fmolbev\u002Fmsw054.\nLi L, Diab S, McGraw S, Barr B, Traslavina R, Higgins R, Talbot T, Blanchard P, Rimoldi G, Fahsbender E, Page B, Phan TG, Wang C, Deng X, Pesavento P, Delwart E. Divergent astrovirus associated with neurologic disease in cattle. Emerg Infect Dis. 2013;9:1385–92. https:\u002F\u002Fdoi.org\u002F10.3201\u002Feid1909.130682.\nMéndez E, Arias CF. Astroviruses. In: Knipe DM, Howley PM, editors. Fields virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 981–1000.\nMohamed FF, Mansour SM, El-Araby IE, Mor SK, Goyal SM. Molecular detection of enteric viruses from diarrheic calves in Egypt. Arch Virol. 2017;162:129–37. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00705-016-3088-0.\nMohamed FF, Mansour SM, Orabi A, El-Araby IE, Ng TFF, Mor SK, Goyal SM. Detection and genetic characterization of bovine kobuvirus from calves in Egypt. Arch Virol. 2018;163:1439–47. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00705-018-3758-1.\nNaccache SN, Peggs KS, Mattes FM, Phadke R, Garson JA, Grant P, Samayoa E, Federman S, Miller S, Lunn MP, Gant V, Chiu CY. Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing. Clin Infect Dis. 2015;60:919–23. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fcid\u002Fciu912.\nNagai M, Omatsu T, Aoki H, Otomaru K, Uto T, Koizumi M, Minami-Fukuda F, Takai H, Murakami T, Masuda T, Yamasato H. Full genome analysis of bovine astrovirus from fecal samples of cattle in Japan: identification of possible interspecies transmission of bovine astrovirus. Arch Virol. 2015;160:2491–501. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00705-015-2543-7.\nNg TFF, Kondov NO, Deng X, Van Eenennaam A, Neibergs HL, Delwart E. A metagenomics and case-control study to identify viruses associated with bovine respiratory disease. J Virol. 2015;89:5340–9. https:\u002F\u002Fdoi.org\u002F10.1128\u002FJVI.00064-15.\nOem JK, An DJ. Phylogenetic analysis of bovine astrovirus in Korean cattle. Virus Genes. 2014;48:372–5. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11262-013-1013-0.\nSharp CP, Gregory WF, Mason C, Barend M, Beard PM. High prevalence and diversity of bovine astroviruses in the faeces of healthy and diarrhoeic calves in South West Scotland. Vet Microbiol. 2015;178:70–6. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetmic.2015.05.002.\nSimon-Loriere E, Holmes EC. Why do RNA viruses recombine? Nat Rev Microbiol. 2011;9:617–26. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnrmicro2614.\nTse H, Chan WM, Tsoi HW, Fan RRY, Lau CCY, Lau SKP, Woo PCY, Yuen KY. Rediscovery and genomic characterization of bovine astroviruses. J Gen Virol. 2011;92:1888–98. https:\u002F\u002Fdoi.org\u002F10.1099\u002Fvir.0.030817-0.\nTuran T, Işidan H. The first detection and phylogenetic analysis of bovine astrovirus from diarrheic calves in Turkey. Etlik Vet Mikrobiyol Derg. 2018;29:104–10. https:\u002F\u002Fdoi.org\u002F10.35864\u002Fevmd.513442.\nVito M, Cristiana C, Paolo C, Georgia D, Michele C, Gianvito L, Galante D, Cafiero MA, Lavazza A, Bányai K, Canio B. Identification of astroviruses in bovine and buffalo calves with enteritis. Res Vet Sci. 2020;131:59–68. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.rvsc.2020.04.010.\nWoode GN, Bridger JC. Isolation of small viruses resembling astroviruses and caliciviruses from acute enteritis of calves. J Med Microbiol. 1978;11:441–52. https:\u002F\u002Fdoi.org\u002F10.1099\u002F00222615-11-4-441.\nWoode GN, Gourley NE, Pohlenz JF, Liebler EM, Mathews SL, Hutchinson MP. Serotypes of bovine astrovirus. J Clin Microbiol. 1985;22:668–70.",{"VOID":1560},"10.1007\u002Fs13337-021-00668-5","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs13337-021-00668-5",[1563,1578,1600,1613,1628,1641],{"id":1564,"sortIndex":32,"researcher":28,"roles":1565,"affiliations":1566,"properties":1575,"displayName":1577,"givenName":28,"familyName":28},"bba85ec6-be63-4dcc-b190-bf059ad0ae74",[958],[1567],{"id":1568,"sortIndex":32,"affiliation":1569,"properties":28},"62a5fcee-64ba-4087-9026-96be84fea51e",{"id":1568,"createTime":28,"updateTime":28,"relativeEntities":1570,"slug":28,"properties":1571,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1574,"statistic":28},[],{"title":1572},{"VI":1573},"Department of Virology, Faculty of veterinary Medicine, Zagazig University, Zagazig, Egypt",[],{"title":1576},{"VI":1577},"Shimaa M. G. 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Several members of the genus Crinivirus are considered emerging viruses. Currently, four criniviruses: Beet pseudo-yellows virus, Cucurbit chlorotic yellows virus, Cucurbit yellow stunting disorder virus and Lettuce infectious yellows virus have been reported to infect field- or greenhouse- grown cucurbits. Apart from their cucurbit hosts, criniviruses infect other cash crops and weeds. Criniviruses are exclusively transmitted by whiteflies. The virion titer and the vector genus or species complex are predominant factors affecting virus transmission. These criniviruses maintain genetic stability with limited intra-species variability. They share similar core genome structure and replication strategies with some variations in the non-core proteins and downstream replication processes. Management of the diseases induced by criniviruses relies on integrated disease management strategies and on resistant varieties, when available. This review will cover their epidemiology, molecular biology, detection and management.","Trong thập kỷ qua, các loại virus crinivirus đã thu hút sự quan tâm do khả năng lây lan nhanh chóng và tính hủy diệt của chúng đối với canh tác cây họ bầu bí. Một số thành viên của chi Crinivirus được coi là virus mới nổi. Hiện tại, bốn loại virus crinivirus đã được báo cáo gây bệnh trên cây họ bầu bí được trồng ngoài đồng hoặc trong nhà kính: virus giả vàng củ cải, virus vàng đốm xanh cây họ bầu bí, virus rối loạn lùn vàng cây họ bầu bí, và virus vàng nhiễm khuẩn rau diếp. Ngoài các chủng cây họ bầu bí, virus crinivirus còn gây bệnh trên các cây trồng thương mại khác và cỏ dại. Virus crinivirus chỉ được truyền qua ruồi trắng. Tỷ lệ virion và loài hoặc đa dạng giống của vật mang virus là những yếu tố quan trọng ảnh hưởng đến quá trình truyền virus. Các loại virus crinivirus này duy trì tính ổn định di truyền với sự biến đổi hạn chế giữa các loài. Chúng có cấu trúc bộ gene lõi và chiến lược sao chép tương tự với một số biến thể trong các protein không lõi và các quá trình sao chép hạ nguồn. Quản lý bệnh do virus crinivirus gây ra dựa vào các chiến lược quản lý dịch bệnh tích hợp và các giống kháng, nếu có. Bài tổng quan này sẽ đề cập đến dịch tễ học, sinh học phân tử, phát hiện và quản lý các loại virus này.",{"EN":1706,"VI":1707},"Whitefly-transmitted criniviruses of cucurbits: current status and future prospects","Virus crinivirus truyền qua ruồi trắng ở cây họ bầu bí: tình trạng hiện tại và triển vọng tương lai",{"VI":1709},"crinivirus, virus họ bầu bí, ruồi trắng, truyền bệnh, quản lý dịch bệnh",{"VOID":1711},"Abou-Jawdah Y, Eid SG, Atamian HS, Havey M. Assessing the movement of Cucurbit yellow stunting disorder virus in susceptible and tolerant cucumber germplasms using serological and nucleic acid-based methods. J Phytopathol. 2008;156:438–45.\nAbou-Jawdah Y, Sobh H, El-Zammar S, Fayyad A, Lecoq H. 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Plant Dis. 2011;95:354.",{"VOID":1713},"10.1007\u002Fs13337-013-0173-9","2025-02-05T14:01:24.837+00:00",[30],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13337-013-0173-9",[1718,1733],{"id":1719,"sortIndex":32,"researcher":28,"roles":1720,"affiliations":1721,"properties":1730,"displayName":1732,"givenName":28,"familyName":28},"7edab839-cc95-41cf-9de3-43a4fe7b7dbe",[958],[1722],{"id":1723,"sortIndex":32,"affiliation":1724,"properties":28},"e9c757c1-852c-4129-8741-f75d346ad978",{"id":1723,"createTime":28,"updateTime":28,"relativeEntities":1725,"slug":28,"properties":1726,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1729,"statistic":28},[],{"title":1727},{"VI":1728},"Department of Agricultural Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon",[],{"title":1731},{"VI":1732},"Peter E. Abrahamian",{"id":1734,"sortIndex":40,"researcher":28,"roles":1735,"affiliations":1736,"properties":1743,"displayName":1745,"givenName":28,"familyName":28},"e171f870-8c2e-4863-a66d-877f8d8ad169",[958],[1737],{"id":1723,"sortIndex":32,"affiliation":1738,"properties":28},{"id":1723,"createTime":28,"updateTime":28,"relativeEntities":1739,"slug":28,"properties":1740,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1742,"statistic":28},[],{"title":1741},{"VI":1728},[],{"title":1744},{"VI":1745},"Yusuf Abou-Jawdah",{"url":1716,"publisher":1747,"properties":1781},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1748,"slug":872,"properties":1749,"entityType":25,"verifyStatus":881,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1753,"manageAffiliations":1762,"indexDatabases":1768,"url":28,"thumbnailPath":28,"statistic":1776,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1750,"title":1751,"eissn":1752},{"VOID":877},{"EN":872},{"VOID":875},[1754,1758],{"id":884,"createTime":28,"updateTime":28,"relativeEntities":1755,"label":1756,"description":1757,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":887},{},{"id":890,"createTime":28,"updateTime":28,"relativeEntities":1759,"label":1760,"description":1761,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":893},{},[1763],{"id":897,"createTime":28,"updateTime":28,"relativeEntities":1764,"slug":28,"properties":1765,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1767,"statistic":28},[],{"title":1766},{"EN":901},[903],[1769],{"id":906,"indexDatabase":1770,"url":912,"indexYears":913,"academicFieldIds":1775,"indexDatabaseRanking":917},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1771,"label":1772,"description":1773,"key":781,"publicationTags":1774,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[915,916],{"impactFactor":32,"impactFactorByYear":1777,"i10Index":136,"i10IndexLast5Year":49,"totalPublication":920,"totalPublicationByYear":1778,"totalCitation":922,"totalCitationByYear":1779,"totalCitationPerPublication":925,"totalCitationPerPublicationByYear":1780,"hindexLast5Year":126,"hindex":126},{"2015":316,"2016":52,"2017":169,"2018":194,"2019":194,"2020":319,"2021":286,"2022":709,"2023":52},{"2013":145,"2014":139,"2015":69,"2016":353,"2017":150,"2018":208,"2019":139,"2020":436,"2021":611,"2022":69,"2023":150,"2024":42},{"2014":924,"2015":159,"2016":159,"2017":611,"2018":324,"2019":148,"2020":830,"2021":147,"2022":131,"2023":123},{"2014":927,"2015":183,"2016":588,"2017":928,"2018":442,"2019":929,"2020":930,"2021":229,"2022":931,"2023":106},{"pages":1782,"volume":1784},{"VOID":1783},"26-38",{"VOID":1785},"25","2013-10-27",2013,[],{"id":1790,"createTime":1791,"updateTime":1792,"relativeEntities":1793,"slug":1794,"properties":1795,"entityType":951,"verifyStatus":26,"verifyTime":1792,"verifyNote":952,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1804,"fullTextUrl":28,"authors":1805,"publicationType":1040,"publisherRelationship":1894,"citationCount":28,"citationInfo":28,"publishDate":1934,"publishYear":1935,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":1936,"openAccess":28,"references":28,"isForceReanalyzing":1084},"06e6e8fe-1baa-466c-97f7-e2cbfeb10686","2024-01-13T07:08:54.217+00:00","2025-01-09T00:49:30.469+00:00",[],"Occurrence-of-granulovirus-infecting-Cydia-pomonella-in-high-altitude-cold-arid-region-of-India",{"abstract":1796,"title":1798,"references":1800,"doi":1802},{"EN":1797},"Codling moth (Cydia pomonella, Lepidoptera: Tortricidae) is a quarantine pest of apple in Ladakh, India. We report Cydia pomonella granulovirus from infected larvae of codling moth for the first time in India. The two CpGV isolates were identified as (CpGV SKUAST-1 and CpGV SKUAST-2) and published in Genbank under accession number, MK801791 and MK801792, respectively. The mortality of CpGV was evaluated against 3rd instar larvae of codling moth at various concentrations viz., 102, 104, 106, 108, 1010, 1012 and 1014 OBS\u002Fml. The median lethal concentrations (LC50 and LC90) were observed at 7.08 and 28.56 OBS\u002Fml, respectively. In field, the infection rate by CpGV was 5.95 to 15.65%. Based on typical infection symptoms on the larvae, morphological features under the microscope and sequence results of the amplified product confirmed the first occurrence of CpGV from India. Thus, CpGV will form an important non-chemical strategy for managing this pest.",{"EN":1799},"Occurrence of granulovirus infecting Cydia pomonella in high altitude cold arid region of India",{"VOID":1801},"Arneodo JD, De Anna J, Salvador R, Farinon M, Quintana G, Sciocco-Cap A. Prospection and molecular analysis of CpGV isolates infecting Cydia pomonella at different geographical locations in Argentina. Ann Appl Biol. 2015;166:67–74.\nAsser-Kaiser S, Fritsch E, Undorf-Spahn K, Kienzle J, Eberle K, Gund NA, Reineke A, Zebitz CPW, Heckel DG, Huber J, Jehle JA. Rapid emergence of baculovirus resistance in codling moth due to dominant, sex-linked inheritance. Science. 2007;318:1916–7.\nAsser-Kaiser S, Radtke P, El-Salamouny S, Winstanley D, Jehle JA. Baculovirus resistance in codling moth (Cydia pomonella L.) caused by early block of virus replication. Virology. 2011;410:360–7.\nBloem S, Carpenter JE, Blomefield TL, Harrison C. Compatibility of codling moths Cydia pomonella (Linnaeus) (Lepidoptera: Tortricidae) from South Africa with codling moths shipped from Canada. J Appl Entomol. 2010;134:201–6.\nBlomefield TL. Codling moth resistance: is it here and how do we manage it? Deciduous Fruit Grower. 1994;44:130–2.\nClem RJ, Robson M, Miller LK. Influence of infection route on the infectivity of baculovirus mutants lacking the apoptosis-inhibiting gene p35 and the adjacent gene p94. J Virol. 1994;68:6759–62.\nCossentine JE, Jensen LBM. Persistence of a commercial codling moth granulovirus product on apple fruit and foliage. J Entomol Soc Br Columbia. 2004;101:87–92.\nCrook NE, Clem RJ, Miller LK. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J Virol. 1993;67:2168–74.\nEPPO. EPPO Global database (available online). Paris, France: EPPO; 2014. https:\u002F\u002Fgd.eppo.int\u002F.\nEastwell KC, Cossentine JE, Bernardy MG. Characterisation of Cydia pomonella granulovirus from codling moths in a laboratory colony and in orchards of British Columbia. Ann Appl Biol. 1999;134:285–91.\nEberle KE, Sayed S, Rezapanah M, Shojai-Estabragh S, Jehle HA. Diversity and evolution of the Cydia pomonella granulovirus. J Gen Virol. 2009;90:662–71.\nFelsenstein J. Confidence limits on phylogenies: an approach using the bootstrap. Evolution. 1985;39:783–91.\nGlen DM, Wiltshire CW, Milsom NF, Brain P. Codling moth granulosis virus: effects of its use on some other orchard arthropods. Ann Appl Biol. 1984;104:99–106.\nHowell JF. Rearing the codling moth on an artificial diet. J Econ Entomol. 1970;63:1148–50.\nHuber J. Western Europe. In: Hunter-Fujita FR, Entwistle PF, Evans HF, Crook NE, editors. Insect viruses and pest management. New York: Wiley; 1998. p. 201–15.\nHussain B, Abidi I, Mohammad I, Ayaz A. First record of Pieris brassicae granulosis virus infecting Pieris brassicae larvae in Kashmir Valley. Trends Biosci. 2014;7:2010–1. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs41938-019-0117-9.\nHussain B, Ahmad B, Sheikh B. Monitoring and mass trapping of codling moth, Cydia pomonella by the use of pheromone baited traps in Kargil, Ladakh India. Int J Fruit Sci. 2015;1:1–9.\nHussain B, Sivakumar G, Kannan M, War AR, Ballal CR. First record of a nucleopolyhedrovirus infecting brown-tail moth larvae, Euproctis chrysorrhoea (L.) (Lepidoptera: Lymantriidae) in India. Egypt J Biol Pest Control. 2019;29(1):11.\nJaques RP, Laing JE, MacLellan CR, Proverbs MD, Sanford KH, Trottier R. Apple orchard tests on the efficacy of the granulosis virus of the codling moth. Laspeyresia pomonella (Lep.: Olethreutidae). Entomophaga. 1981;26:111–8.\nJehle JA, Lange M, Wang H, Hu Z, Wang Y, Hauschild R. Molecular identification and phylogenetic analysis of baculoviruses from Lepidoptera. Virology. 2006;346:180–93.\nJehle JA, Schulze-Bopp S, Undorf-Spahn K, Fritsch E. Evidence for a second type of resistance against Cydia pomonella granulovirus (CpGV) in codling moth field populations. Appl Environ Microbiol. 2017;83:e02330-e2416.\nJina PS. Tourism in Ladakh Himalaya. New Delhi: Indus Publishing; 1994. p. 212.\nLacey LA, Frutos R, Kaya HK, Vail P. Insect pathogens as biological control agents: do they have a future? Biol Control. 2001;21:230–48.\nLacey LA, Thomson D, Vincent C, Arthurs SP. Codling moth granulovirus: a comprehensive review. Biocontrol Sci Technol. 2008;18(7):639–63.\nMasoodi MA, Trali AR, Bhat AM, Tikoo RK, Nehru RK. Phenological studies on codling moth Laspeyresia pomonella in Ladakh. Environ Ecol. 1987;5(2):253–6.\nPandey AK, Namgyal D. Bio-ecology of codling moth (Cydia pomonella L.) damaging apple in Kargil district of Ladakh region. J Entomol Res. 2014;38(2):131–3.\nPawar AD, Parry M. Occurrence of codling moth, Cydia pomonella (L.) in Nobra Valley and other areas of Ladakh (J and K). Indian J Plant Prot. 1989;17(2):291–3.\nPawar AD, Tuhan NC, Balasubramaniam S, Parry M. Biological control of codling moth in Ladakh. Indian J Plant Prot. 1980;8(2):189–91.\nRehman MU, Hussain B, Mir MM, Angmo T, Parray E, Zubair M. Low productivity of fruits, its implications and combating strategies in cold arid eco-region of Ladakh (J and K). Curr J Appl Sci Technol. 2020;39:122–8.\nSaitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987;4:406–25.\nSauer AJ, Fritsch E, Undorf-Spahn K, Nguyen P, Marec F, Heckel DG, et al. Novel resistance to Cydia pomonella granulovirus (CpGV) in codling moth shows autosomal and dominant inheritance and confers cross-resistance to different CpGV genome groups. PLoS ONE. 2017;12(6):e0179157.\nSchmitt A, Bisutti IL, Ladurner E, Benuzzi M, Sauphanor B, Kienzle J, et al. The occurrence and distribution of resistance of codling moth to Cydia pomonella granulovirus in Europe. J Appl Entomol. 2013;137(9):641–9.\nSmith IRL, Crook NE. In vivo isolation of baculovirus genotypes. Virology. 1988;166:240–4.\nStobdan T, Angmo S, Angchok D, Paljor E, Dawa T, Tsetan T, Chaurasia OP. Vegetable production scenario in trans-Himalayan Leh Ladakh region, India. Defence Life Sci J. 2018;3(1):85–92.\nTanada Y. A granulosis virus of codling moth, Carpocapsa pomonella (Linnaeus) (Olethreutidae, Lepidoptera). J Insect Pathol. 1964;6(3):378–80.\nZaki FA. Incidence and biology of codling moth, Cydia pomonella L., in Ladakh (Jammu and Kashmir). Appl Biol Res. 1999;1:75–8.",{"VOID":1803},"10.1007\u002Fs13337-020-00638-3","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13337-020-00638-3",[1806,1821,1836,1851,1864,1879],{"id":1807,"sortIndex":32,"researcher":28,"roles":1808,"affiliations":1809,"properties":1818,"displayName":1820,"givenName":28,"familyName":28},"6f78ef79-fb1f-480b-a326-1c5bb612a229",[958],[1810],{"id":1811,"sortIndex":32,"affiliation":1812,"properties":28},"20c7d227-a816-4ae8-99b3-debdc4414e1e",{"id":1811,"createTime":28,"updateTime":28,"relativeEntities":1813,"slug":28,"properties":1814,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1817,"statistic":28},[],{"title":1815},{"VI":1816},"Division of Entomology, Sher-E-Kashmir University of Agriculture Science and Technology, Kashmir (SKUAST-K), Shalimar, Srinagar, India",[],{"title":1819},{"VI":1820},"Barkat Hussain",{"id":1822,"sortIndex":40,"researcher":28,"roles":1823,"affiliations":1824,"properties":1833,"displayName":1835,"givenName":28,"familyName":28},"74502461-52bf-4441-841a-db51aa919aaf",[958],[1825],{"id":1826,"sortIndex":32,"affiliation":1827,"properties":28},"1ba32277-f2d6-4bf6-a219-847e41d156bc",{"id":1826,"createTime":28,"updateTime":28,"relativeEntities":1828,"slug":28,"properties":1829,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1832,"statistic":28},[],{"title":1830},{"VI":1831},"Division of Plant Biotechnology, SKUAST-K, Srinagar, India",[],{"title":1834},{"VI":1835},"Khalid Z. Masoodi",{"id":1837,"sortIndex":123,"researcher":28,"roles":1838,"affiliations":1839,"properties":1848,"displayName":1850,"givenName":28,"familyName":28},"4783f4a4-4140-4741-9929-a7004a29d106",[958],[1840],{"id":1841,"sortIndex":32,"affiliation":1842,"properties":28},"2f4e757e-f260-4d08-aece-90318197291e",{"id":1841,"createTime":28,"updateTime":28,"relativeEntities":1843,"slug":28,"properties":1844,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1847,"statistic":28},[],{"title":1845},{"VI":1846},"Rohama Rafiabad, Baramulla, India",[],{"title":1849},{"VI":1850},"Abdul Rasheed War",{"id":1852,"sortIndex":42,"researcher":28,"roles":1853,"affiliations":1854,"properties":1861,"displayName":1863,"givenName":28,"familyName":28},"add50e06-94bb-42cf-b2fb-bdca2fe37679",[958],[1855],{"id":1826,"sortIndex":32,"affiliation":1856,"properties":28},{"id":1826,"createTime":28,"updateTime":28,"relativeEntities":1857,"slug":28,"properties":1858,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1860,"statistic":28},[],{"title":1859},{"VI":1831},[],{"title":1862},{"VI":1863},"Asma S. 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A total of 460 goat serum samples were tested by using c-ELISA for the presence of antibodies against PPR. Out of the 460 samples tested, 380 samples were found positive, giving overall sero-positivity of 82.60%. Significantly higher sero-prevalence was found (*P \u003C 0.05) in females (87.50%) compared to males (70.45%) and crossbreed goats were found highly susceptible than the pure breed goats (*P \u003C 0.05). Likewise, higher sero-prevalence of PPR was observed in adults and cross breed goats compared to their counterparts and significantly higher sero-prevalence was observed in Syangja district compared to Kaski. Thus, adults, females and cross-breeds populations of goats are at higher risk of PPR whereas geographically, goat population of Syangja district were found significantly prone to PPR. Appropriate control measures, such as ring vaccination can be followed to prevent the potential outbreak situation.",{"EN":1947},"Cross-sectional sero-prevalence study of Peste des Petits Ruminants (PPR) in goats of Syangja and Kaski districts of Nepal",{"VOID":1949},"Abdalla AS, Majok AA, El Malik KH, Ali AS. Sero-prevalence of peste des petits ruminants virus (PPRV) in small ruminants in Blue Nile, Gadaref and North Kordofan States of Sudan. J Public Heal Epidemiol. 2012;4:59–64.\nAbubakar M, Rasool MH, Manzoor S, Saqalein M, Rizwan M, et al. Evaluation of risk factors for peste des petits ruminants virus in sheep and goats at the wildlife-livestock interface in Punjab province, Pakistan. Biomed Res Int. 2016;2016:7826245.\nAbubakar M, Zahur AB, Afzal M, Ali Q, Gonzales J. Peste des Petits Ruminants (PPR) in Pakistan: analysis of a national level serological data. Small Rumin Res. 2017;155:57–65.\nAbubakar M, Mahapatra M, Muniraju M, Arshed MJ, Khan EH, Banyard AC, et al. Serological detection of antibodies to peste des petits ruminants virus in large ruminants. Transbound Emerg Dis. 2017;64:513–9.\nAl-Majali AM, Hussain NO, Amarin NM, Majok AA. Seroprevalence of, and risk factors for, peste des petits ruminants in sheep and goats in Northern Jordan. Prev Vet Med. 2008;85:1–8.\nAnnual Technical Report [Internet]. Tripureshwor, Kathmandu, Central Veterinary Laboratory, Department of Livestock Services, Ministry of Livestock Development, Government of Nepal. 2015. http:\u002F\u002Fwww.cvl.gov.np\u002Fuploads\u002Ffiles\u002F5324820354.pdf. Accessed 22 Dec 2017.\nBaazizi R, Mahapatra M, Clarke BD, Ait-Oudhia K, Khelef D, Parida S. Peste des petits ruminants (PPR): a neglected tropical disease in Maghreb region of North Africa and its threat to Europe. PLoS ONE. 2017;12:e0175461.\nBalamurugan V, Saravanan P, Sen A, Rajak KK, Venkatesan G, Krishnamoorthy P, et al. Prevalence of peste des petits ruminants among sheep and goats in India. J Vet Sci. 2012;13:279–85.\nBalamurugan V, Krishnamoorthy P, Raju DSN, Rajak KK, Bhanuprakash V, Pandey AB, et al. Prevalence of Peste-des-petits-ruminant virus antibodies in cattle, buffaloes, sheep and goats in India. Virusdisease. 2014;25:85–90.\nBalamurugan V, Das S, Raju DSN, Chakravarty I, Nagalingam M, Hemadri D, et al. Prevalence of peste des petits ruminants in goats in North-East India. Virusdisease. 2014;25:488–92.\nBanyard AC, Parida S, Batten C, Oura C, Kwiatek O, Libeau G. Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control. J Gen Virol. 2010;91:2885–97.\nBanyard AC, Wang Z, Parida S. Peste des petits ruminants virus, eastern Asia. Emerg Infect Dis. 2014;20:2176–8.\nBello AM, Lawal JR, Dauda J, Wakil Y, Lekko YM, Mshellia ES, et al. Research for peste des petits ruminants (PPR) virus antibodies in goats, sheep and gazelle from Bauchi and Gombe states, North Eastern Nigeria. Direct Res J Agric Food Sci. 2016;4:193–8.\nBhaskar SR, Deshmukh VV, Chopade NA, Rautmare SS. Seroprevalence of Peste Des Petits Ruminants in Maharashtra. Indian J Anim Res. 2009;43:285–7.\nDaniel WW, editor. Biostatistics: a foundation for analysis in the health sciences. 7th ed. New York: Wiley; 1999.\nDhar P, Sreenivasa B, Barrett T, Corteyn M, Singh R, Bandyopadhyay S. Recent epidemiology of peste des petits ruminants virus (PPRV). Vet Microbiol. 2002;88:153–9.\nDoAH. Annual Epidemiological Bulletin. Tripureshwor, Kathmandu: Veterinary Epidemiological Centre, Directorate of Animal Health; 2015.\nEl-Yuguda AD, Abubakar MB, Nabi AB, Andrew A, Baba SS. Outbreak of peste des petits ruminant in an unvaccinated Sahel goat farm in Maiduguri, Nigeria. Afr J Biomed Res. 2008;12:83–7.\nIslam M, Hasan A, Yousuf A, Islam UK, Mahfuz M, Khan A. Seroprevalence of Peste des Petits Ruminant Virus specific antibody in goats in different regions of Bangladesh. J Adv Vet Anim Res. 2016;7710:127–33.\nJanus A, Tresamol PV, Saseendranath MR, Vijayakumar K, Pillai UN. Seroprevalence of PPR in goats in Kerala by cELISA. J Vet Anim Sci. 2009;40:15–6.\nJha VK, Singh DB, Thakuri KC, Gautam SP. National workshop. In: Gurung TB, Joshi BR, Singh UM, Paudel KP, Shrestha BS, Rijal KP et al (eds) Research & development strategies for goat enterprises in Nepal. 2013. https:\u002F\u002Fwww.researchgate.net\u002Fprofile\u002FTek_Gurung\u002Fpublication\u002F257143203_Proceedings_of_the_National_Workshop_on_Research_and_Development_Strategies_for_Goat_Enterprises_in_Nepal\u002Flinks\u002F0deec524bc1267ea34000000\u002FProceedings-of-the-National-Workshop-on-Research. Accessed 9 Nov 2017\nKhakural GP. Surveillance of goat diseases in the Western Hills of Nepal. Nepal J Sci Technol. 2003;5:37–40.\nKhakural GP, Upreti CR. Proceedings of the 3rd national workshop on livestock and fisheries research in Nepal. 1999. p. 148–52. http:\u002F\u002Fcoin.fao.org\u002Fcoin-static\u002Fcms\u002Fmedia\u002F22\u002F14376249192440\u002Fa_compendium_of_livestock_and_fisheries_research_highlights_in_nepal.pdf. Accessed 9 Nov 2017.\nKhan HA, Siddique M, Sajjad-Ur-Rahman, Abubakar M, Ashraf M. The detection of antibody against peste des petits ruminants virus in Sheep, Goats, Cattle and Buffaloes. Trop Anim Health Prod. 2008;40:521–7.\nKihu SM, Gachohi JM, Ndungu EK, Gitao GC, Bebora LC, John NM, et al. Sero-epidemiology of Peste des petits ruminants virus infection in Turkana County, Kenya. BMC Vet Res. 2015;11:87.\nMahajan S, Agrawal R, Kumar M, Mohan A, Pande N. Risk of seroconversion to peste des petits ruminants (PPR) and its association with species, sex, age and migration. Small Rumin Res. 2012;104:195–200.\nMariner JC, Jones BA, Rich KM, Thevasagayam S, Anderson J, Jeggo M, et al. The opportunity to eradicate peste des petits ruminants. J Immunol. 2016;196:3499–506.\nMehmood A, Ali Q, Gadahi JA, Malik SA, Shah SI. Detection of peste des petits ruminants (PPR) virus antibodies in sheep and goat populations of the north west frontier province (NWFP) of Pakistan by competitive elisa (cELISA). Vet World. 2009;2:333–6.\nNaing L, Winn T, Rusli BN. Practical issues in calculating the sample size for prevalence studies. Arch Orofac Sci. 2006;1:9–14.\nNizamani AR, Nizamani ZA, Umrani AP, Dewani P, Vandiar MA, Gandahi JA, et al. Prevalence of peste des petits ruminants virus antibodies in small Ruminantsin Sindh, Pakistan. J Anim Plant Sci. 2015;25:1515–9.\nOzkul A, Akca Y, Alkan F, Barrett T, Karaoglu T, Dagalp SB, et al. Prevalence, distribution, and host range of Peste des petits ruminants virus, Turkey. Emerg Infect Dis. 2002;8:708–12.\nParida S, Muniraju M, Mahapatra M, Muthuchelvan D, Buczkowski H, Banyard AC. Peste des petits ruminants. 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Emerg Infect Dis. 2009;15:299–301.",{"VOID":1951},"10.1007\u002Fs13337-018-0449-1","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13337-018-0449-1",[1954,1971,1986],{"id":1955,"sortIndex":32,"researcher":28,"roles":1956,"affiliations":1957,"properties":1968,"displayName":1970,"givenName":28,"familyName":28},"5cef3e2b-097f-4a55-8865-c59ee8f4c896",[958],[1958],{"id":1959,"sortIndex":32,"affiliation":1960,"properties":1966},"2571f49f-5400-46ed-9558-3d686929c848",{"id":1959,"createTime":28,"updateTime":28,"relativeEntities":1961,"slug":28,"properties":1962,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1965,"statistic":28},[],{"title":1963},{"EN":1964},"Texas Tech University, Lubbock, USA",[],{"title":1967},{"VI":1964},{"title":1969},{"VI":1970},"Narayan Acharya",{"id":1972,"sortIndex":40,"researcher":28,"roles":1973,"affiliations":1974,"properties":1983,"displayName":1985,"givenName":28,"familyName":28},"9d4bc2e2-eab4-49ff-9424-dc0e98f8fcf9",[958],[1975],{"id":1976,"sortIndex":32,"affiliation":1977,"properties":28},"7ade3c68-b506-4431-8685-059d64da1ecd",{"id":1976,"createTime":28,"updateTime":28,"relativeEntities":1978,"slug":28,"properties":1979,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1982,"statistic":28},[],{"title":1980},{"VI":1981},"Institute of Agriculture and Animal Science (IAAS), Rampur, Chitwan, Nepal",[],{"title":1984},{"VI":1985},"Shankar Prasad Poudel",{"id":1987,"sortIndex":123,"researcher":28,"roles":1988,"affiliations":1989,"properties":1998,"displayName":2000,"givenName":28,"familyName":28},"7f39fb49-bd8b-4833-a78e-46f5c13a7a4e",[958],[1990],{"id":1991,"sortIndex":32,"affiliation":1992,"properties":28},"47d456c7-7222-46ab-8bf9-4601bc27fdb1",{"id":1991,"createTime":28,"updateTime":28,"relativeEntities":1993,"slug":28,"properties":1994,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1997,"statistic":28},[],{"title":1995},{"VI":1996},"Regional Veterinary Laboratory (RVL), Pokhara, Nepal",[],{"title":1999},{"VI":2000},"Krishna Prasad Acharya",{"url":1952,"publisher":2002,"properties":2036},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2003,"slug":872,"properties":2004,"entityType":25,"verifyStatus":881,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2008,"manageAffiliations":2017,"indexDatabases":2023,"url":28,"thumbnailPath":28,"statistic":2031,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":2005,"title":2006,"eissn":2007},{"VOID":877},{"EN":872},{"VOID":875},[2009,2013],{"id":884,"createTime":28,"updateTime":28,"relativeEntities":2010,"label":2011,"description":2012,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":887},{},{"id":890,"createTime":28,"updateTime":28,"relativeEntities":2014,"label":2015,"description":2016,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":893},{},[2018],{"id":897,"createTime":28,"updateTime":28,"relativeEntities":2019,"slug":28,"properties":2020,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2022,"statistic":28},[],{"title":2021},{"EN":901},[903],[2024],{"id":906,"indexDatabase":2025,"url":912,"indexYears":913,"academicFieldIds":2030,"indexDatabaseRanking":917},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2026,"label":2027,"description":2028,"key":781,"publicationTags":2029,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[915,916],{"impactFactor":32,"impactFactorByYear":2032,"i10Index":136,"i10IndexLast5Year":49,"totalPublication":920,"totalPublicationByYear":2033,"totalCitation":922,"totalCitationByYear":2034,"totalCitationPerPublication":925,"totalCitationPerPublicationByYear":2035,"hindexLast5Year":126,"hindex":126},{"2015":316,"2016":52,"2017":169,"2018":194,"2019":194,"2020":319,"2021":286,"2022":709,"2023":52},{"2013":145,"2014":139,"2015":69,"2016":353,"2017":150,"2018":208,"2019":139,"2020":436,"2021":611,"2022":69,"2023":150,"2024":42},{"2014":924,"2015":159,"2016":159,"2017":611,"2018":324,"2019":148,"2020":830,"2021":147,"2022":131,"2023":123},{"2014":927,"2015":183,"2016":588,"2017":928,"2018":442,"2019":929,"2020":930,"2021":229,"2022":931,"2023":106},{"pages":2037,"volume":2039},{"VOID":2038},"173-179",{"VOID":1234},"2018-04-06",[917],{"id":2043,"createTime":2044,"updateTime":2045,"relativeEntities":2046,"slug":2047,"properties":2048,"entityType":951,"verifyStatus":26,"verifyTime":2045,"verifyNote":952,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":2057,"fullTextUrl":28,"authors":2058,"publicationType":1040,"publisherRelationship":2122,"citationCount":28,"citationInfo":28,"publishDate":2162,"publishYear":2163,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":2164,"openAccess":28,"references":28,"isForceReanalyzing":1084},"0929da98-d2f8-4f82-a133-7d9e4913084c","2024-01-26T23:45:17.713+00:00","2025-01-24T09:45:05.605+00:00",[],"Molecular-characterization-and-phylogenetic-analyses-of-virulent-infectious-bronchitis-viruses-isolated-from-chickens-in-Eastern-Saudi-Arabia",{"abstract":2049,"title":2051,"references":2053,"doi":2055},{"EN":2050},"\nInfectious bronchitis virus (IBV) is one of the major respiratory viral threats for chickens. Despite the intensive application of IBV vaccines, several outbreaks have been reported worldwide. Here, we report several IBV outbreaks in thirteen poultry farms in Eastern Saudi Arabia (ESA) from 2013 to 2014. The main goals of the current study were as follows: (1) isolation and molecular characterization of the currently circulating strains in ESA (Al-Hasa, Dammam, and Buqayq) and (2) evaluation of the immune status of these birds to IBV. To achieve our goals, tissue specimens (trachea, lungs, liver, kidney and cecal tonsils) and sera were collected. High morbidity up to 100% and mortality ranging from 18 to 90% were reported. Severe infection was observed in the trachea, bronchi, and kidneys of the infected birds. IBV strains were isolated using embryonated chicken eggs. The isolated viruses induced hemorrhage, dwarfing and death of the inoculated embryos 3–5 days post-infection. The circulating IBV strains were identified by sequencing the partial IBV-N and IBV-S1 genes. These viruses showed 95% sequence identity to Indian, Italian, Egyptian and Chinese strains and were quite distinct from the locally used vaccines on the genomic level. Interestingly, high antibody titers against IBV were reported in some of these farms, suggesting the presence of new virulent strains in ESA. The seroconversion of infected birds was reported among the affected flocks. In conclusion, very virulent IBV strains are currently circulating in ESA. Further studies are currently in progress to molecularly characterize these IBV strains.\n",{"EN":2052},"Molecular characterization and phylogenetic analyses of virulent infectious bronchitis viruses isolated from chickens in Eastern Saudi Arabia",{"VOID":2054},"Ababneh M, Dalab AE, Alsaad S, Al-Zghoul M. Presence of infectious bronchitis virus strain CK\u002FCH\u002FLDL\u002F97I in the Middle East. ISRN Vet Sci. 2012;2012:201721. doi:10.5402\u002F2012\u002F201721.\nAbdel-Moneim AS, El-Kady MF, Ladman BS, Gelb J. 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Vaccine. 2006;24(47–48):6830–8. doi:10.1016\u002Fj.vaccine.2006.06.040..\nToro H, Pennington D, Gallardo RA, van Santen VL, van Ginkel FW, Zhang J, et al. Infectious bronchitis virus subpopulations in vaccinated chickens after challenge. Avian Dis. 2012;56(3):501–8. doi:10.1637\u002F9982-110811-Reg.1.\nYan F, Zhao Y, Hu Y, Qiu J, Lei W, Ji W, et al. Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine. J Vet Sci. 2013;14(1):53–60.\nZaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814–20. doi:10.1056\u002FNEJMoa1211721.\nZhang J, Guo Y, Xiao Y, Wang X, Li Z, Hu S, et al. A simple and rapid strip test for detection of antibodies to avian infectious bronchitis virus. J Vet Med Sci. 2010;72(7):883–6.\nZhao G, Jiang Y, Qiu H, Gao T, Zeng Y, Guo Y, et al. Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with middle east respiratory syndrome-coronavirus. PLoS ONE. 2015;10(12):e0145561. doi:10.1371\u002Fjournal.pone.0145561.",{"VOID":2056},"10.1007\u002Fs13337-017-0375-7","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13337-017-0375-7",[2059,2083,2096,2109],{"id":2060,"sortIndex":32,"researcher":28,"roles":2061,"affiliations":2062,"properties":2080,"displayName":2082,"givenName":28,"familyName":28},"78b7d38d-13a9-46dc-9d24-e888f4d255cd",[958],[2063,2071],{"id":2064,"sortIndex":32,"affiliation":2065,"properties":28},"f0a0569d-2eca-4b36-afa4-717e4ae8b614",{"id":2064,"createTime":28,"updateTime":28,"relativeEntities":2066,"slug":28,"properties":2067,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2070,"statistic":28},[],{"title":2068},{"VI":2069},"Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia",[],{"id":2072,"sortIndex":40,"affiliation":2073,"properties":2079},"494937ce-c817-4c76-8cfa-0f55d64e343a",{"id":2072,"createTime":28,"updateTime":28,"relativeEntities":2074,"slug":28,"properties":2075,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2078,"statistic":28},[],{"title":2076},{"VI":2077},"Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt",[],{},{"title":2081},{"VI":2082},"Maged Gomaa Hemida",{"id":2084,"sortIndex":40,"researcher":28,"roles":2085,"affiliations":2086,"properties":2093,"displayName":2095,"givenName":28,"familyName":28},"a612b805-5bd0-4a7d-ac72-0fce3117edc6",[958],[2087],{"id":2064,"sortIndex":32,"affiliation":2088,"properties":28},{"id":2064,"createTime":28,"updateTime":28,"relativeEntities":2089,"slug":28,"properties":2090,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2092,"statistic":28},[],{"title":2091},{"VI":2069},[],{"title":2094},{"VI":2095},"Mohammed A. 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In the present study, Piper yellow mottle virus (PYMoV), a badnavirus infecting black pepper was shown to occur as endogenous virus based on the PCR, reverse transcription (RT)-PCR, ELISA and Southern hybridization tests. Black pepper plants that tested positive in PCR for PYMoV gave negative reaction in RT-PCR indicating that they harbour endogenous PYMoV (ePYMoV) sequences. The RT-PCR (−ve) plants tested negative in ELISA and also in PCR using outword primers to amplify the full circular genome. Further, the presence of ePYMoV sequences in the black pepper genome was confirmed by Southern hybridization analysis using cloned PYMoV genomic fragments as probes. Among different open reading frames (ORFs) of the virus, ORF 3 was more frequently integrated. This is the first report of occurrence of ePYMoV sequences in black pepper genome.",{"EN":2175},"Occurrence of endogenous Piper yellow mottle virus in black pepper",{"VOID":2177},"Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Short protocols in molecular biology. New York: Wiley; 1995.\nBhat AI, Hohn T, Selvarajan R. Badnaviruses: the current global scenario. Viruses. 2016;8:177. doi:10.3390\u002Fv8060177.\nDeeshma KP, Bhat AI. Complete genome sequencing of Piper yellow mottle virus infecting black pepper, betelvine, and Indian long pepper. Virus Genes. 2015;50:172–5.\nEid S, Pappu R. Expression of endogenous para-retroviral genes and molecular analysis of the integration events in its plant host Dahlia variabilis. Virus Genes. 2014;48:153–9.\nGeering AD, Maumus F, Copetti D, Choisne N, Zwickl DJ, Zytnicki M, McTaggart AR, Scalabrin S, Vezzulli S, Wing RA, Quesneville H. Endogenous florendoviruses are major components of plant genomes and hallmarks of virus evolution. Nat Commun. 2014;5:1–11.\nGeering ADW, Olszewski NEO, Dahal G, Thomas JE. Analysis of the distribution and structure of integrated Banana streak virus DNA in a range of Musa cultivars. Mol Plant Pathol. 2001;2:207–13.\nHany U, Adams IP, Glover R, Bhat AI, Boonham N. The complete genome sequence of Piper yellow mottle virus (PYMoV). Arch Virol. 2014;159:385–8.\nHareesh PS, Bhat AI. Detection and partial nucleotide sequence analysis of Piper yellow mottle virus infecting black pepper in India. Indian J Virol. 2008;19:160–7.\nHarper G, Hull R, Lockhart B, Olszewski N. Virus sequences integrated to plant genomes. Annu Rev Phytopathol. 2002;40:119–36.\nIskra-Caruana ML, Chabannes M, Duroy PO, Muller E. A possible scenario for the evolution of Banana streak virus in banana. Virus Res. 2014;186:155–62.\nLaney AG, Hassan M, Tzanetakis IE. An integrated badnavirus is prevalent in fig germplasm. Phytopathology. 2012;102:1182–9.\nLockhart BEL, Kirtisak KA, Jones P, Padmini DD, Olszieewski NE, Lockhart N, Nuarchan D, Sangalang J. Identification of Piper yellow mottle virus, a mealy bug transmited badnavirus infecting Piper spp. in South East Asia. Eur J Plant Pathol. 1997;103:303–11.\nNdowora T, Dahal G, LaFleur D, Harper G, Hull R, Olszewski NE, Lockhart B. Evidence that Badnavirus infection in Musa can originate from integrated sequences. Virology. 1999;255:214–20.\nSambrook J, Russell DW. Southern blotting. In: Argentine J, Irwin N, Janssen KA, Curtis S, Zierler M, McInerny N, Brown D, Schaefer S, editors. Molecular cloning: a laboratory manual, vol. 1. New York: Cold Spring Harbor Press; 2011. p. 6.33–47.\nSeal S, Turaki A, Muller E, Kumar PL, Kenyon L, Filloux D, Galzi S, Lopez-Montes A, Iskra-Caruana ML. The prevalence of badnaviruses in West African yams (Dioscorea cayenensis-rotundata) and evidence of endogenous pararetrovirus sequences in their genomes. Virus Res. 2014;186:144–54.\nSu L, Gao S, Huang Y, Ji C, Wang D, Ma Y, Fang R, Chen X. Complete genomic sequence of Dracaena mottle virus, a distinct badnavirus. Virus Genes. 2007;35:423–9.\nUmadevi P, Bhat AI, Krishnamurthy KS, Anandaraj M. Influence of temperature on symptom expression, detection of host factors in virus infected black Piper nigrum L. Indian J Exp Biol. 2016;54:354–60.\nUmber M, Filloux D, Muller E, Laboureau N, Galzi S, Roumagnac P, Iskra-Caruana ML, Pavis C, Teycheney PY, Seal SE. The genome of African yam (Dioscorea cayenensis-rotundata complex) hosts endogenous sequences from four distinct badnavirus species. Mol Plant Pathol. 2014;15:790–801.\nYang IC, Hafner GJ, Revill PA, Dale JL, Harding RM. Sequence diversity of South Pacific isolates of Taro bacilliform virus and the development of a PCR-based diagnostic test. Arch Virol. 2003;148:1957–66.\nYang Z, Nicotaisen M, Olszewski NE, Lockhart BE. Sequencing, improved detection, and a novel form of Kalanchoë top-spotting virus. Plant Dis. 2005;89:298–302.",{"VOID":2179},"10.1007\u002Fs13337-017-0369-5","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs13337-017-0369-5",[2182,2197],{"id":2183,"sortIndex":32,"researcher":28,"roles":2184,"affiliations":2185,"properties":2194,"displayName":2196,"givenName":28,"familyName":28},"cf7b6f00-6266-44d9-920b-a01c23b069c3",[958],[2186],{"id":2187,"sortIndex":32,"affiliation":2188,"properties":28},"1c1df579-fdce-4649-9bbc-46a14dc9ee31",{"id":2187,"createTime":28,"updateTime":28,"relativeEntities":2189,"slug":28,"properties":2190,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2193,"statistic":28},[],{"title":2191},{"VI":2192},"Division of Crop Protection, ICAR-Indian Institute of Spices Research, Kozhikode, India",[],{"title":2195},{"VI":2196},"K. P. 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