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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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of Cytomegalovirus (CMV) knowledge among healthcare professionals has been proven to be the main threat to pregnant women's awareness, preventing them from reducing the risk of infection. The aims of this study were to assess the knowledge and practices of French-speaking Swiss perinatal professionals in terms of CMV prevention, as well as the sociodemographic-professional factors that influence them. This observational study used a cross-sectional design to collect data-via an anonymous electronic questionnaire in French distributed to gynecologists-obstetricians, general practitioners and midwives via various channels: e-mails and social networks of partner centers, professional associations, and conferences. The 41-item questionnaire collected data on sociodemographic and professional characteristics, general CMV knowledge, national recommendation knowledge and prevention practices. Univariable and multivariable analyses were performed. A total of 110 gynecologist-obstetricians, 5 general practitioners and 226 midwives participated in the study. While more than 80% of practitioners were familiar with protective hygiene measures, significant gaps were highlighted concerning the transmission routes, as well as the signs of short- and long-term congenital CMV infection. Regarding practice, 63.3% of participants provided information on CMV to their patients, mainly during the first antenatal visit. Among those who did not, lack of knowledge and forgetfulness were the two main reasons cited. Concerning systematic screening, 45.7% of participants offered it to their patients, and 37.3% only offered it to “at risk” groups. The existence of national guidelines on CMV was known by 62.0% of participants. Multivariable analysis revealed that working as a gynecologist-obstetrician was independently associated with higher score of preventive practices, while performing ultrasound or preconception consultations was independently associated with a higher score of general CMV knowledge, and working in a university hospital was independently associated with a higher score of Swiss recommendation knowledge. A level of training higher than the basic medical or midwifery diploma and participation in fetal medicine symposia both promote a higher score of CMV knowledge and prevention practices in line with current recommendations. This study confirms the significant gaps in CMV knowledge among French-speaking Swiss caregivers along with the heterogeneity of their prevention practices. To raise awareness among pregnant women and reduce the burden of congenital CMV infections, improving professional knowledge through access to specific training and standardizing practices should be a national priority.",{"EN":1289},"Cytomegalovirus infection during pregnancy: cross-sectional survey of knowledge and prevention practices of healthcare professionals in French-speaking Switzerland",{"EN":1291},"",{"VOID":1293},"Davis NL, King CC, Kourtis AP. Cytomegalovirus infection in pregnancy. Birth Defects Res. 2017;109(5):336–46.\nNavti OB, Al-Belushi M, Konje JC. Cytomegalovirus infection in pregnancy—an update. Eur J Obstet Gynecol Reprod Biol. 2021;258:216–22.\nLeruez-Ville M, Foulon I, Pass R, Ville Y. Cytomegalovirus infection during pregnancy: state of the science. Am J Obstet Gynecol. 2020;223(3):330–49.\nBarton M, Forrester AM, McDonald J. Update on congenital cytomegalovirus infection: prenatal prevention, newborn diagnosis, and management. Paediatr Child Health. 2020;25(6):395–6.\nCheeran MC, Lokensgard JR, Schleiss MR. Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev. 2009;22(1):99–126.\nFoulon I, Naessens A, Foulon W, Casteels A, Gordts F. A 10-year prospective study of sensorineural hearing loss in children with congenital cytomegalovirus infection. J Pediatr. 2008;153(1):84–8.\nLeruez-Ville M, Stirnemann J, Sellier Y, et al. Feasibility of predicting the outcome of fetal infection with cytomegalovirus at the time of prenatal diagnosis. Am J Obstet Gynecol. 2016;215(3):342e1–9.\nNance WE, Lim BG, Dodson KM. Importance of congenital cytomegalovirus infections as a cause for pre-lingual hearing loss. J Clin Virol. 2006;35(2):221–5.\nDollard SC, Grosse SD, Ross DS. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol. 2007;17(5):355–63.\nRevello MG, Tibaldi C, Masuelli G, et al. Prevention of primary cytomegalovirus infection in pregnancy. EBioMedicine. 2015;2(9):1205–10.\nPicone O, Grangeot-Keros L, Senat M, et al. Cytomegalovirus non-primary infection during pregnancy. Can serology help with diagnosis? J Matern Fetal Neonatal Med. 2017;30(2):224–7.\nHadar E, Dorfman E, Bardin R, Gabbay-Benziv R, Amir J, Pardo J. Symptomatic congenital cytomegalovirus disease following non-primary maternal infection: a retrospective cohort study. BMC Infect Dis. 2017;17(1):31.\nArnouts L, Van Mechelen K, Laroche S, et al. Non-primary CMV infection not always innocent. A case-report and literature review. Acta Clin Belg. 2022;77(1):96–100.\nSchäffer L ON, Boulvain M, Baud D, Raio L, Duppenthaler A, et al. Cytomégalovirus (CMV) et grossesse. 2021. https:\u002F\u002Fwww.sggg.ch\u002Ffileadmin\u002Fuser_upload\u002F73_Cytomegalievirus_und_Schwangerschaft_F_aktualisiert.pdf (accessed 02.22.2022.\nFowler KB, Boppana SB. Congenital cytomegalovirus infection. Semin Perinatol. 2018;42(3):149–54.\nDahle AJ, Fowler KB, Wright JD, Boppana SB, Britt WJ, Pass RF. Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. J Am Acad Audiol. 2000;11(5):283–90.\nSmithers-Sheedy H, Raynes-Greenow C, Badawi N, et al. Congenital Cytomegalovirus among Children with Cerebral Palsy. J Pediatr. 2017;181:267-71e1.\nCordier AG, Vauloup-Fellous C, Picone O. Is maternal infection with cytomegalovirus prevention possible? Gynecol Obstet Fertil. 2010;38(10):620–3.\nVauloup-Fellous C, Picone O, Cordier AG, et al. Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy? Results of a 3-year prospective study in a French hospital. J Clin Virol. 2009;46(Suppl 4):S49-53.\nJohnson J, Anderson B, Pass RF. Prevention of maternal and congenital cytomegalovirus infection. Clin Obstet Gynecol. 2012;55(2):521–30.\nThigpen J. Congenital cytomegalovirus-history, current practice, and future opportunities. Neonatal Netw. 2020;39(5):293–8.\nBillette de Villemeur A, Tattevin P, Salmi LR, French Haut Conseil de la sante publique Working G. Hygiene promotion might be better than serological screening to deal with Cytomegalovirus infection during pregnancy: a methodological appraisal and decision analysis. BMC Infect Dis. 2020;20(1):418.\nCordier AG, Guitton S, Vauloup-Fellous C, Grangeot-Keros L, Benachi A, Picone O. Awareness and knowledge of congenital cytomegalovirus infection among health care providers in France. J Clin Virol. 2012;55(2):158–63.\nCalvert A, Vandrevala T, Parsons R, et al. Changing knowledge, attitudes and behaviours towards cytomegalovirus in pregnancy through film-based antenatal education: a feasibility randomised controlled trial of a digital educational intervention. BMC Pregnancy Childbirth. 2021;21(1):565.\nPesch MH, Saunders NA, Abdelnabi S. Cytomegalovirus infection in pregnancy: prevention, presentation, management and neonatal outcomes. J Midwifery Womens Health. 2021;66(3):397–402.\nBeaudoin ML, Renaud C, Boucher M, Kakkar F, Gantt S, Boucoiran I. Perspectives of women on screening and prevention of CMV in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2021;258:409–13.\nLim SL, Tan WC, Tan LK. Awareness of and attitudes toward congenital cytomegalovirus infection among pregnant women in Singapore. Int J Gynaecol Obstet. 2012;117(3):268–72.\nWillame A, Blanchard-Rohner G, Combescure C, Irion O, Posfay-Barbe K, de Tejada BM. Awareness of cytomegalovirus infection among pregnant women in Geneva, Switzerland: a cross-sectional study. Int J Environ Res Public Health. 2015;12(12):15285–97.\nPomar L. Awareness and knowledge of congenital cytomegalovirus infection among pregnant women in French-speaking Switzerland; 2023.\nFellah T, Sibiude J, Vauloup-Fellous C, et al. Evolution of awareness and knowledge of congenital cytomegalovirus infection among health care providers in France between 2011 and 2018. J Clin Virol. 2020;129:104335.\nKorver AM, de Vries JJ, de Jong JW, Dekker FW, Vossen AC, Oudesluys-Murphy AM. Awareness of congenital cytomegalovirus among doctors in the Netherlands. J Clin Virol. 2009;46(Suppl 4):S11–5.\nMuldoon KM, Armstrong-Heimsoth A, Thomas J. Knowledge of congenital cytomegalovirus (cCMV) among physical and occupational therapists in the United States. PLoS ONE. 2017;12(10):e0185635.\nHosseinzadeh Adli A, Karami C, Baghban Rahimi S, Mirarab A, Tabarraei A. What family doctors know about congenital CMV: a regional survey in Iran. Ital J Pediatr. 2018;44(1):31.\nSmithers-Sheedy H, Swinburn K, Waight E, et al. eLearning significantly improves maternity professionals’ knowledge of the congenital cytomegalovirus prevention guidelines. Aust N Z J Obstet Gynaecol. 2022;62:445–52.\nClémence Merçay AG, Peter Dolder. Personnel de santé en Suisse – Rapport national 2021. Effectifs, besoins, offre et mesures pour assurer la relève. Office fédéral de la statistique, CH2010 Neuchâtel. Impression réalisée en Suisse, 2021\nFMH. Médecins en exercice par discipline principale et par canton; 2022. In: FMH Sg, editor. 2022.\nSages-femmes Fsd. Feuille d’information: les sages-femmes en Suisse, 2021.\nCordier AG, Guitton S, Vauloup-Fellous C, et al. Awareness of cytomegalovirus infection among pregnant women in France. J Clin Virol. 2012;53(4):332–7.\nCannon MJ. Congenital cytomegalovirus (CMV) epidemiology and awareness. J Clin Virol. 2009;46(Suppl 4):S6-10.\nMazzitelli M, Micieli M, Votino C, et al. Knowledge of human cytomegalovirus infection and prevention in pregnant women: a baseline. Oper Surv Infect Dis Obstet Gynecol. 2017;2017:5495927.\nPesch MH, Anderson C, Mowers E. Improving obstetric provider congenital cytomegalovirus knowledge and practices. Infect Dis Obstet Gynecol. 2020;2020:8875494.\nCastillo K, Hawkins-Villarreal A, Valdes-Bango M, et al. Congenital cytomegalovirus awareness and knowledge among health professionals and pregnant women: an action towards prevention. Fetal Diagn Ther. 2022;49(5–6):265–72.\nConfédération Suisse DfdliD, Office fédéral de la santé publique OFSP. OFSP-Bulletin 49\u002F2018 Magazine d'information pour professionnel de la santé et pour les médias. 2018.\nL’Huillier AG, Crisinel PA. Congenital toxoplasmosis and CMV in Switzerland in 2019. Rev Med Suisse. 2020;16(682):361–4.\nConfédération Suisse OfdlspO. Politique extérieure suisse en matière de santé (PES). 2019. https:\u002F\u002Fwww.bag.admin.ch\u002Fbag\u002Ffr\u002Fhome\u002Fstrategie-und-politik\u002Finternationale-beziehungen\u002Fschweizer-gesundheitsaussenpolitik.html (accessed 25.04.2022 2022).\nWalker SP, Palma-Dias R, Wood EM, Shekleton P, Giles ML. Cytomegalovirus in pregnancy: to screen or not to screen. BMC Pregnancy Childbirth. 2013;13:96.\nLetamendia-Richard E, Perillaud-Dubois C, de La Guillonniere L, et al. Universal newborn screening for congenital cytomegalovirus infection: feasibility and relevance in a French type-III maternity cohort. BJOG. 2022;129(2):291–9.\nChiopris G, Veronese P, Cusenza F, et al. Congenital cytomegalovirus infection: update on diagnosis and treatment. Microorganisms. 2020;8(10):1516.\nLeruez-Ville M, Magny JF, Couderc S, et al. Risk factors for congenital cytomegalovirus infection following primary and nonprimary maternal infection: a prospective neonatal screening study using polymerase chain reaction in Saliva. Clin Infect Dis. 2017;65(3):398–404.\nVille Y. Advocating for cytomegalovirus maternal serologic screening in the first trimester of pregnancy: if you do not know where you are going, you will wind up somewhere else. Am J Obstet Gynecol MFM. 2021;3(4):100356.\nFaure-Bardon V, Fourgeaud J, Stirnemann J, Leruez-Ville M, Ville Y. Secondary prevention of congenital cytomegalovirus infection with valacyclovir following maternal primary infection in early pregnancy. Ultrasound Obstet Gynecol. 2021;58(4):576–81.\nGievers LL, Holmes AV, Loyal J, et al. Ethical and public health implications of targeted screening for congenital cytomegalovirus. Pediatrics 2020; 146(1).\nDegos V. Pour une décision médicale équilibrée. Revue Leannec. 2014;4(62):8–13.\nAebi-Popp K, Kahlert C, Rauch A, et al. Heterogeneity in testing practices for infections during pregnancy: national survey across Switzerland. Swiss Med Wkly. 2016;146:w14325.\nPetignat P-A. Les guidelines sont-ils des standards à suivre? Revue Médicale Suisse. 2009;5:2271–5.\nMontague A, Vandrevala T, Calvert A, et al. Experiences of pregnant women and healthcare professionals of participating in a digital antenatal CMV education intervention. Midwifery. 2022;106:103249.\nBaer HR, McBride HE, Caviness AC, Demmler-Harrison GJ. Survey of congenital cytomegalovirus (cCMV) knowledge among medical students. J Clin Virol. 2014;60(3):222–42.\nvon Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. 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B virus is a hepatotropic DNA virus that reproduces via an RNA intermediate. It can lead to an increased risk of serious liver diseases such as hepatocellular carcinoma and is a serious threat to public health. Currently, the HBV are designated based on greater than 8% nucleotide variation along the whole genome. The recombination of HBV is very common, a large majority of which are recombinants between 2 genotypes. The current work aims to characterize a suspected recombinant involving 3 genotypes. Fifty-seven HBV full-genome sequences were obtained from 57 patients co-infected with HBV and HIV-1 by amplification coupled with sequencing. JpHMM and RDP4 were used to perform recombination analysis respectively. The recombination results of a suspected 3-genotypic recombinant were further confirmed by both maximum likelihood phylogenetic tree and Mrbayes tree. JpHMM recombination analysis clearly indicated one 3-genotypic HBV recombinant composing of B\u002FC\u002FD. The genotype assignments are supported by significant posterior probabilities. The subsequent phylogenetic analysis of sub-regions derived from inferred breakpoints led to a disagreement on the assignment of D segment. Investigating the conflict, further exploration by RDP4 and phylogenies revealed that the jpHMM-derived 3-genotypic recombinant is actually a B\u002FC genotypic recombinant with C fragment spanning 1899 to 2295 (jpHMM) or 1821 to 2199 (RDP4). The whole analysis indicated that (i) determination of small genomic regions should be performed with more caution, (ii) combinations of various recombination detection approaches conduce to obtain impartial results, and (iii) a unified system of nomenclature of HBV genotypes is necessary.",{"EN":1670},"Characterization of small genomic regions of the hepatitis B virus should be performed with more caution",{"VOID":1672},"Arankalle VA, Gandhe SS, Borkakoty BJ, Walimbe AM, Biswas D, Mahanta J. A novel HBV recombinant (genotype I) similar to Vietnam\u002FLaos in a primitive tribe in eastern India. J Viral Hepat. 2010;17:501–10.\nAraujo NM. Hepatitis B virus intergenotypic recombinants worldwide: an overview. Infecti Genet Evol. 2015;36:500–10.\nArauz-Ruiz P, Norder H, Robertson BH, Magnius LO. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol. 2002;83:2059–73.\nBenson DA, Cavanaugh M, Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J, Sayers EW. GenBank. Nucleic Acids Res. 2013;41:D36–42.\nBoni MF, Posada D, Feldman MW. An exact nonparametric method for inferring mosaic structure in sequence triplets. Genetics. 2007;176:1035–47.\nChen X, Dai B, Liu Z, Gao J, Ji Z, Guo J, Chen G, Deng Z, Shao Z. A novel B\u002FC inter-genotype recombinant of hepatitis B virus identified in north-West China. J Gen Virol. 2014;95:153–5.\nFang ZL, Hue S, Sabin CA, Li GJ, Yang JY, Chen QY, Fang KX, Huang J, Wang XY, Harrison TJ. A complex hepatitis B virus (X\u002FC) recombinant is common in long an county, Guangxi and may have originated in southern China. J Gen Virol. 2011;92:402–11.\nGalibert F, Mandart E, Fitoussi F, Tiollais P, Charnay P. Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature. 1979;281:646–50.\nGanem D, Prince AM. Hepatitis B virus infection — natural history and clinical consequences. N Engl J Med. 2004;350:1118–29.\nGibbs MJ, Armstrong JS, Gibbs AJ. Sister-scanning: a Monte Carlo procedure for assessing signals in recombinant sequences. Bioinformatics. 2000;16:573–82.\nGuindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59:307–21.\nHayer J, Jadeau F, Deléage G, Kay A, Zoulim F, Combet C. HBVdb: a knowledge database for hepatitis B virus. Nucleic Acids Res. 2013;41:D566–70.\nHolmes EC, Worobey M, Rambaut A. Phylogenetic evidence for recombination in dengue virus. Mol Biol Evol. 1999;16:405–9.\nJia L, Gui T, Li L, Liu S, Li H, Bao Z, Wang X, Zhuang D, Li T, Han J, Liu Y, Li J. A considerable proportion of CRF01_AE strains in China originated from circulating intrasubtype recombinant forms (CIRF). BMC Infect Dis. 2015;15:528.\nJia L, Li L, Gui T, Liu S, Li H, Han J, Guo W, Liu Y, Li J. Analysis of HIV-1 intersubtype recombination breakpoints suggests region with high pairing probability may be a more fundamental factor than sequence similarity affecting HIV-1 recombination. Virol J. 2016;13:1–12.\nJia L, Li L, Li H, Liu S, Wang X, Bao Z, Li T, Zhuang D, Liu Y, Li J. Recombination pattern reanalysis of some HIV-1 circulating recombination forms suggest the necessity and difficulty of revision. PLoS One. 2014;9:e107349.\nKiwelu IE, Novitsky V, Margolin L, Baca J, Manongi R, Sam N, Shao J, McLane MF, Kapiga SH, Essex M. Frequent intra-subtype recombination among HIV-1 circulating in Tanzania. PLoS One. 2013;8:e71131.\nLiang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y, Wang F, Zheng H, Guo J, Jia Z, Ma J, Wang H, Luo H, Li L, Jin S, Hadler SC, Wang Y. Epidemiological serosurvey of hepatitis B in China—declining HBV prevalence due to hepatitis B vaccination. Vaccine. 2009;27:6550–7.\nMahgoub S, Candotti D, El Ekiaby M, Allain JP. Hepatitis B virus (HBV) infection and recombination between HBV genotypes D and E in asymptomatic blood donors from Khartoum, Sudan. J Clin Microbiol. 2011;49:298–306.\nMartin DP, Lemey P, Lott M, Moulton V, Posada D, Lefeuvre P. RDP3: a flexible and fast computer program for analyzing recombination. Bioinformatics. 2010;26:2462–3.\nMartin DP, Murrell B, Golden M, Khoosal A, Muhire B. RDP4: detection and analysis of recombination patterns in virus genomes. Virus Evolution. 2015;1:vev003.\nMartin DP, Posada D, Crandall KA, Williamson C. A modified bootscan algorithm for automated identification of recombinant sequences and recombination breakpoints. AIDS Res Hum Retrovir. 2005;21:98–102.\nMorozov V, Pisareva M, Groudinin M. Homologous recombination between different genotypes of hepatitis B virus. Gene. 2000;260:55–65.\nNaumann H, Schaefer S, Yoshida CF, Gaspar AM, Repp R, Gerlich WH. Identification of a new hepatitis B virus (HBV) genotype from Brazil that expresses HBV surface antigen subtype adw4. J Gen Virol. 1993;74(Pt 8):1627–32.\nNorder H, Courouce AM, Magnius LO. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology. 1994;198:489–503.\nNorder H, Hammas B, Löfdahl S, Couroucé A-M, Magnius LO. Comparison of the amino acid sequences of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains. JGen Virol. 1992;73:1201–8.\nOkamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, Mayumi M. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol. 1988;69:2575–83.\nPadidam M, Sawyer S, Fauquet CM. Possible emergence of new geminiviruses by frequent recombination. Virology. 1999;265:218–25.\nPosada D, Crandall KA. Evaluation of methods for detecting recombination from DNA sequences: computer simulations. Proc Natl Acad Sci U S A. 2001;98:13757–62.\nRonquist F, Teslenko M, van der Mark P, Ayres DL, Darling A, Höhna S, Larget B, Liu L, Suchard MA, Huelsenbeck JP. MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Syst Biol. 2012;61:539–42.\nSalminen MO, Carr JK, Burke DS, McCutchan FE. Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning. AIDS Res Hum Retrovir. 1995;11:1423–5.\nSchultz AK, Bulla I, Abdou-Chekaraou M, Gordien E, Morgenstern B, Zoaulim F, Deny P, Stanke M. jpHMM: recombination analysis in viruses with circular genomes such as the hepatitis B virus. Nucleic Acids Res. 2012;40:W193–8.\nSchultz AK, Zhang M, Bulla I, Leitner T, Korber B, Morgenstern B, Stanke M. jpHMM: improving the reliability of recombination prediction in HIV-1. Nucleic Acids Res. 2009;37:W647–51.\nSchultz AK, Zhang M, Leitner T, Kuiken C, Korber B, Morgenstern B, Stanke M. A jumping profile hidden Markov model and applications to recombination sites in HIV and HCV genomes. BMC Bioinform. 2006;7:265.\nSeeger C, Mason WS. Hepatitis B Virus Biology. Microbiol Mol Biol Rev. 2000;64:51–68.\nSentandreu V, Jimenez-Hernandez N, Torres-Puente M, Bracho MA, Valero A, Gosalbes MJ, Ortega E, Moya A, Gonzalez-Candelas F. Evidence of recombination in intrapatient populations of hepatitis C virus. PLoS One. 2008;3:e3239.\nShih C, Chou S-F, Yang C-C, Huang J-Y, Choijilsuren G, Jhou R-S. Control and eradication strategies of hepatitis B virus. Trends Microbiol. 2016;24:739–49.\nSimmonds P, Midgley S. Recombination in the genesis and evolution of hepatitis B virus genotypes. J Virol. 2005;79:15467–76.\nSmith JM. Analyzing the mosaic structure of genes. J Mol Evol. 1992;34:126–9.\nStuyver L, De Gendt S, Van Geyt C, Zoulim F, Fried M, Schinazi RF, Rossau R. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol. 2000;81:67–74.\nSugauchi F, Orito E, Ichida T, Kato H, Sakugawa H, Kakumu S, Ishida T, Chutaputti A, Lai C-L, Ueda R, Miyakawa Y, Mizokami M. Hepatitis B virus of genotype B with or without recombination with genotype C over the Precore region plus the Core gene. J Virol. 2002;76:5985–92.\nTamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol. 2013;30:2725–9.\nTongo M, Dorfman JR, Martin DP. High degree of HIV-1 group M (HIV-1M) genetic diversity within circulating recombinant forms: insight into the early events of HIV-1M evolution. J Virol. 2016;90:2221–9.\nTran TT, Trinh TN, Abe K. New complex recombinant genotype of hepatitis B virus identified in Vietnam. J Virol. 2008;82:5657–63.\nYan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J, Li W. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. ELife. 2012;1:e00049.\nZhang M, Foley B, Schultz AK, Macke JP, Bulla I, Stanke M, Morgenstern B, Korber B, Leitner T. The role of recombination in the emergence of a complex and dynamic HIV epidemic. Retrovirology. 2010;7:25.",{"VOID":1674},"10.1186\u002Fs12985-018-1100-x","https:\u002F\u002Fvirologyj.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12985-018-1100-x",[1677,1692,1707,1720,1733,1746,1759,1772,1785,1798],{"id":1678,"sortIndex":32,"researcher":28,"roles":1679,"affiliations":1680,"properties":1689},"5c4ac322-3daa-436c-a4f5-6b782e19da75",[977],[1681],{"id":1682,"sortIndex":32,"affiliation":1683,"properties":28},"44ece006-4c8e-4402-9977-77f40880bfe8",{"id":1682,"createTime":28,"updateTime":28,"relativeEntities":1684,"slug":28,"properties":1685,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1688,"statistic":28},[],{"title":1686},{"VI":1687},"Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China",[],{"title":1690},{"VI":1691},"Lei 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fever (LF) is a devastating hemorrhagic viral disease that is endemic to West Africa and responsible for thousands of human deaths each year. Analysis of humoral immune responses (IgM and IgG) by antibody-capture ELISA (Ab-capture ELISA) and Lassa virus (LASV) viremia by antigen-capture ELISA (Ag-capture ELISA) in suspected patients admitted to the Kenema Government Hospital (KGH) Lassa Fever Ward (LFW) in Sierra Leone over the past five years is reshaping our understanding of acute LF. Analyses in LF survivors indicated that LASV-specific IgM persists for months to years after initial infection. Furthermore, exposure to LASV appeared to be more prevalent in historically non-endemic areas of West Africa with significant percentages of reportedly healthy donors IgM and IgG positive in LASV-specific Ab-capture ELISA. We found that LF patients who were Ag positive were more likely to die than suspected cases who were only IgM positive. Analysis of metabolic and immunological parameters in Ag positive LF patients revealed a strong correlation between survival and low levels of IL-6, -8, -10, CD40L, BUN, ALP, ALT, and AST. Despite presenting to the hospital with fever and in some instances other symptoms consistent with LF, the profiles of Ag negative IgM positive individuals were similar to those of normal donors and nonfatal (NF) LF cases, suggesting that IgM status cannot necessarily be considered a diagnostic marker of acute LF in suspected cases living in endemic areas of West Africa. Only LASV viremia assessed by Ag-capture immunoassay, nucleic acid detection or virus isolation should be used to diagnose acute LASV infection in West Africans. LASV-specific IgM serostatus cannot be considered a diagnostic marker of acute LF in suspected cases living in endemic areas of West Africa. By applying these criteria, we identified a dysregulated metabolic and pro-inflammatory response profile conferring a poor prognosis in acute LF. In addition to suggesting that the current diagnostic paradigm for acute LF should be reconsidered, these studies present new opportunities for therapeutic interventions based on potential prognostic markers in LF.",{"EN":1875},"Emerging trends in Lassa fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection",{"VOID":1877},"McCormick JB: Clinical, epidemiologic, and therapeutic aspects of Lassa fever. Med Microbiol Immunol. 1986, 175: 153-5. 10.1007\u002FBF02122438.\nMcCormick JB: Epidemiology and control of Lassa fever. Current Topics in Microbiol and Immunol. 1987, 134: 69-78. 10.1007\u002F978-3-642-71726-0_3.\nFisher-Hoch SP, McCormick JB: Lassa fever vaccine: A review. Expert Rev Vaccines. 2004, 3: 103-11.\nFisher-Hoch SP, Tomori O, Nasidi A, Perez-Oronoz GI, Fakile Y, Hutwagner L, McCormick JB: Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice. 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Emerg Infect Dis. 2000, 6 (5): 466-476. 10.3201\u002Feid0605.000504.\nHaas WH, Breuer T, Pfaff G, Schmitz H, Köhler P, Asper M, Emmerich P, Drosten C, Gölnitz U, Fleischer K, Günther S: Imported Lassa fever in Germany: surveillance and management of contact persons. Clin Infect Dis. 2003, 36 (10): 1254-1258. 10.1086\u002F374853.\nHensley LE, Smith MA, Geisbert JB, Fritz EA, Daddario-DiCaprio KM, Larsen T, Geisbert TW: Pathogenesis of lassa fever in cynomolgus macaques. Virol J. 2011, 8: 205-10.1186\u002F1743-422X-8-205.",{"VOID":1879},"10.1186\u002F1743-422X-8-478","https:\u002F\u002Fvirologyj.biomedcentral.com\u002Farticles\u002F10.1186\u002F1743-422X-8-478",[1882,1897,1912,1934,1949,1964,1986,2006,2030],{"id":1883,"sortIndex":32,"researcher":28,"roles":1884,"affiliations":1885,"properties":1894},"2eaffd81-ccff-4ba5-b751-0b7d7670a913",[977],[1886],{"id":1887,"sortIndex":32,"affiliation":1888,"properties":28},"1774c687-8a94-489e-b00d-e24ccb6454aa",{"id":1887,"createTime":28,"updateTime":28,"relativeEntities":1889,"slug":28,"properties":1890,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1893,"statistic":28},[],{"title":1891},{"VI":1892},"Autoimmune Technologies, LLC, New Orleans, Louisiana, USA",[],{"title":1895},{"VI":1896},"Luis M 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murine leukemia virus (MLV)-related virus (XMRV) is a gammaretrovirus that was discovered in prostate cancer tissues. Recently, it has been proposed that XMRV is a laboratory contaminant and may have originated via a rare recombination event. Host restriction factor APOBEC3G (A3G) has been reported to severely restrict XMRV replication in human peripheral blood mononuclear cells. Interestingly, XMRV infects and replicates efficiently in prostate cancer cells of epithelial origin. It has been proposed that due to lack off or very low levels of A3G protein XMRV is able to productively replicate in these cells. This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines. We demonstrate the presence of A3G in prostate epithelial cell lines (LNCaP and DU145) by western blot and mass spectrometry. We believe the discrepancy in A3G detection is may be due to selection and sensitivity of A3G antibodies employed in the prior studies. Our results also indicate that XMRV produced from A3G expressing LNCaP cells can infect and replicate in target cells. Most importantly our data reveal downregulation of A3G in XMRV infected LNCaP and DU145 cells. We propose that XMRV replicates efficiently in prostate epithelial cells by downregulating A3G expression. Given that XMRV lacks accessory proteins such as HIV-1 Vif that are known to counteract A3G function in human cells, our data suggest a novel mechanism by which retroviruses can counteract the antiviral effects of A3G proteins.",{"EN":2107},"Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells",{"VOID":2109},"Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Tubbs RR, Ganem D, Silverman RH, DeRisi JL: Identification of a novel gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoSPathog 2006, 2: e25.\nArnold RS, Makarova NV, Osunkoya AO, Suppiah S, Scott TA, Johnson NA, Bhosle SM, Liotta D, Hunter E, Marshall FF, et al.: XMRV infection in patients with prostatecancer: novel serologic assay and correlation with PCR andFISH. Urology 2010, 75: 755-761. 10.1016\u002Fj.urology.2010.01.038\nDong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, DeRisi JL, Chow SA, Silverman RH: An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. ProcNatlAcadSci USA 2007, 104: 1655-60. 10.1073\u002Fpnas.0610291104\nSchlaberg R, Choe DJ, Brown KR, Thaker HM, Singh IR: XMRV ispresent in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors. ProcNatlAcadSci USA 106: 16351-16356.\nSabunciyan S, Mandelberg N, Rabkin CS, Yolken R, Viscidi R: No difference in antibody titers against xenotropicMLV related virus in prostate cancer cases and cancer-freecontrols. Mol Cell Probes 2010, 25: 134-136.\nFischer N, Hellwinkel O, Schulz C, Chun FK, Huland H, Aepfelbacher M, Schlomm T: Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. J ClinVirol 2008, 43: 277-83.\nHohn O, Krause H, Barbarotto P, Niederstadt L, Beimforde N, Miller K, Kurth R, Bannert N: Lack of evidence for xenotropic murine leukemia virus-related virus (XMRV) in German prostate cancer patients. Retrovirology 2009, 6: 92. 10.1186\u002F1742-4690-6-92\nVerhaegh GW, de Jong AS, Smit FP, et al.: Prevalence of human xenotropic murine leukemia virus-related gammaretrovirus (XMRV) in Dutch prostate cancer patients. Prostate 2010, 71: 415-20.\nAloia AL, Sfanos KS, Isaacs WB, et al.: XMRV: a new virus in prostate cancer? Cancer Res 2010, 70: 10028-33. 10.1158\u002F0008-5472.CAN-10-2837\nPaprotka T, Delviks-Frankenberry KA, Cingöz O, Martinez A, Kung H-J, Tepper CG, Hu W-S, Fivash MJ Jr, Coffin MJ, Pathak VK: Recombinant Origin of the Retrovirus XMRV. Science 2011, in press. 31 May 2011\u002FPage 1\u002F10.1126\u002Fscience.1205292\nSheehy AM, Gaddis NC, Choi JD, Malim MH: Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 2002, 418: 646-650. 10.1038\u002Fnature00939\nGabuzda DH, et al.: Role of vif in replication of human immunodeficiencyvirus type 1 in CD4 T lymphocytes. J Virol 1992, 66: 6489-6495.\nBogerd HP, Zhang FDBP, Cullen BR: Human APOBEC3proteins can inhibit xenotropic murine leukemia virus-related virus infectivity. Virology 2011, 410: 234-239. 10.1016\u002Fj.virol.2010.11.011\nGroom HC, Yap MW, Galao RP, Neil SJ, Bishop KN: Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors. Proc Natl Acad Sci USA 2010, 107: 5166-5171. 10.1073\u002Fpnas.0913650107\nPaprotka T, et al.: Inhibition of xenotropic murine leukemia virusrelated virus by APOBEC3 proteins and antiviral drugs. J Virol 2010, 84: 5719-5729. 10.1128\u002FJVI.00134-10\nStieler K, Fischer N: Apobec 3 G efficiently reduces infectivity of the human exogenousgammaretrovirus XMRV. PLoS One 2010, 5: e11738. 10.1371\u002Fjournal.pone.0011738\nPaprotka T, et al.: Inhibition of xenotropic murine leukemia virusrelatedvirus by APOBEC3 proteins in PBMCS. J Virol 2011, 85: 4888-4897. 10.1128\u002FJVI.00046-11\nRodriguez JJ, Goff SP: Xenotropic murine leukemia virus-related virus establishes an efficient spreading infection and exhibits enhanced transcriptional activity in prostate carcinoma cells. J Virol 2010,84(5):2556-62. 10.1128\u002FJVI.01969-09\nKnouf EC, et al.: Multiple integrated copies and high-level production of the human retrovirus XMRV from 22Rv1 prostate carcinoma cells. J Virol 2009, 83: 7353-7356. 10.1128\u002FJVI.00546-09\nDerse D, Hill SA, Princler G, Lloyd P, Heidecker G: Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid. Proc Natl Acad Sci USA 2007, 104: 2915-2920. 10.1073\u002Fpnas.0609444104\nDoehle BP, Schafer A, Wiegand HL, Bogerd HP, Cullen BR: Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion. J Virol 2005, 79: 8201-8207. 10.1128\u002FJVI.79.13.8201-8207.2005\nAbudu A, Takaori-Kondo A, Izumi T, Shirakawa K, Kobayashi M, et al.: Murine retrovirus escapes from murine APOBEC3 via two distinct novel mechanisms. Curr Biol 2006, 16: 1565-1570. 10.1016\u002Fj.cub.2006.06.055\nAn P, Bleiber G, Duggal P, Nelson G, May M, Mangeat B, Alobwede I, Trono D, Vlahov D, Donfield S, Goedert JJ, Phair J, Buchbinder S, O'Brien SJ, Telenti A, Winkler CA: APOBEC3G Genetic Variants and Their Influence on the Progression to AIDS. J Virol 2004, 78: 11070-11076. 10.1128\u002FJVI.78.20.11070-11076.2004\nChiu Y, Soros VB, Kreisberg J, Stopak K, Yonemoto Wes, Greene WC: Cellular APOBEC3G restricts HIV-1 infection in resting CD4+T cells. Nature 2005, 435: 108-114. 10.1038\u002Fnature03493\nTriques K, Stevenson M: Characterization of restrictions to human immunodeficiency virus type 1 infection of monocytes. 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foot and mouth disease (HFMD) is usually caused by Enterovirus 71(EV71), and Coxsackievirus A16 (CV-A16) in Guangzhou, the biggest city of South China. However, Coxsackievirus A6 (CV-A6) were observed increased dramatically from 2010–2012. In order to understand and to describe the epidemiologic and genetic characteristics of CV-A6, specimens of 5482 suspected HFMD cases were collected and examined by real-time fluorescence PCR. All samples positive for enteroviruses were analyzed by descriptive statistics. Phylogenetic analysis of CV-A6 based on the VP1 sequences was performed to investigate molecular and evolutionary characteristics. Coxsackievirus A6 increased dramatically from 9.04% in 2010 to 23.21% in 2012 and became one of the main causative agents of HFMD in Guangzhou. CV-A6 attack rates were highest in one to two year olds (33.14%). Typical clinic symptoms of CV-A6 HFMD include fever (589\u002F720, 81.81%), maculopopular rash and vesicular exanthema around the perioral area (408\u002F720, 56.66%), intraoral (545\u002F720, 75.69%), the buttock (395\u002F720, 54.86%), the trunk (244\u002F720, 33.89%), the knee (188\u002F720, 26.11%), and the dorsal aspects of hands (437\u002F720, 60.69%). Phylogenetic analysis showed the CV-A6 isolates in this study belonged to Cluster A1 and were similar to those found in Shanghai in 2011 and 2012 (JX495148, KC414735), Shenzhen in 2011 (JX473394), Japan in 2011 (AB649243, AB649246), France in 2010(HE572928), Thailand in 2012(JX556564) and Israel in 2012 and 2013(.KF991010, KF991012).",{"EN":2258},"Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012",{"VOID":2260},"Robinson CR, Doane FW, Rhodes AJ: Report of an outbreak of febrile illness with pharyngeal lesions and exanthema: Toronto, summer 1957- isolation of group A Coxsackie virus. Can Med Assoc J 1958, 79: 615-621.\nKennett ML, Birch CJ, Lewis FA, Yung AP, Locamini SA, Gust ID: Enterovirus type 71 infection in Melbourne. Bull World Health Organ 1974, 51: 609-615.\nEggertson L: Infectious disease experts monitor outbreaks of enterovirus 71 in Asia. CMA J 2012, 184: E781-E782. 10.1503\u002Fcmaj.109-4291\nZhu J, Luo Z, Wang J, Xu Z, Chen H, Fan D, Gao N, Ping G, Zhou Z, Zhang Y, An J: Phylogenetic analysis of enterovirus 71 circulating in Beijing, China from 2007 to 2009. PLoS One 2013, 8: e56318. 10.1371\u002Fjournal.pone.0056318\nSun LM, Zheng HY, Zheng HZ, Xue G, He JF, Cuan DW, Kang ML, Liu Z, Ke CW, Li JS, Liu L, Guo RN, Hiromu Y, Lin JY: An enterovirus 71 epidemic in Guangdong Province of China, 2008: epidemiological, clinical, and virogenic manifestations. Jpn J Infect Dis 2011, 64: 13-18.\nZhang Y, Zhu Z, Yang W, Ren J, Tan X, Wang Y, Mao N, Xu S, Zhu S, Cui A, Zhang Y, Yan D, Li Q, Dong X, Zhang J, Zhao Y, Wan J, Feng Z, Sun J, Wang S, Li D, Xu W: An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J 2010, 7: 94. 10.1186\u002F1743-422X-7-94\nWang Y, Feng Z, Yang Y, Self S, Gao Y, Longini IM, Wakefield J, Zhang J, Wang L, Chen X, Yao L, Stanaway JD, Wang Z, Yang W: Hand, foot, and mouth disease in China: patterns of spread and transmissibility during 2008–2009. Epidemiology 2011, 22: 781-792. 10.1097\u002FEDE.0b013e318231d67a\nLi L, He Y, Yang H, Zhu J, Xu X, Dong J, Zhu YF, Jin Q: Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People’s Republic of China. J Clin Microbiol 2005, 43: 3835-3839. 10.1128\u002FJCM.43.8.3835-3839.2005\nLiang HY, Kang Y, Tao X, Li MX, Luo L: [Dynamic analysis of the epidemiological characteristics of hand-foot-mouth disease during 2008–2011, Guangzhou]. J Tropi Medici 2011,11(12):1410-1413. Chinese\nLu QB, Zhang XA, Wo Y, Xu HM, Li XJ, Wang XJ, Ding SJ, Chen XD, He C: Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009–2011. PLoS One 2012, 7: p.e52073. 10.1371\u002Fjournal.pone.0052073\nDavia JL, Bel PH, Ninet VZ, Bracho MA, González-Candelas F, Salaza A, Gobernado M, Bosch IF: Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses. Pediatr Dermatol 2011, 28: 1-5. 10.1111\u002Fj.1525-1470.2010.01161.x\nMirand A, Henquell C, Archimbaud C, Ughetto S, Antona D, Bailly JL, Peigue-Lafeuille H: Outbreak of hand, foot and mouth disease\u002Fherpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin Microbiol Infect 2012, 18: E110-E118. 10.1111\u002Fj.1469-0691.2012.03789.x\nFlett K, Youngster I, Huang J, McAdam A, Sandora TJ, Rennick M, Smole S, Rogers SL, Nix WA, Oberste MS, Gellis S, Ahmed AA: Hand, foot, and mouth disease caused by coxsackievirus A6. Emerg Infect Dis 2012, 18: 1702-1704.\nCenters for Disease Control and Prevention Notes from the field: Severe hand, foot, and mouth disease associated with coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 2011-February 2012. Morb Mortal Wkly Rep 2012, 61: 213-214.\nBen-Chetrit E, Wiener-Well Y, Shulman LM, Cohen MJ, Elinav H, Sofer D, Feldman I, Marva E, Wolf DG: Coxsackievirus A6-related hand foot and mouth disease: skin manifestations in a cluster of adult patients. J Clin Virol 2014, 59: 201-203. 10.1016\u002Fj.jcv.2013.12.012\nLeitch EC, Harvala H, Robertson I, Ubillos I, Templeton K, Simmonds P: Direct identification of human enterovirus serotypes in cerebrospinal fluid by amplification and sequencing of the VP1 region. J Clin Virol 2009, 44: 119-124. 10.1016\u002Fj.jcv.2008.11.015\nHu YF, Yang F, Du J, Zhang T, Wu ZQ, Xue Y, Jin Q: Complete genome analysis of coxsackievirus A2, A4, A5, and A10 isolates isolated from hand, foot, and mouth disease patients in China revealing frequent recombination of human enterovirus A. J Clin Microbiol 2011, 49: 2426-2434. 10.1128\u002FJCM.00007-11\nLu QB, Zhang XA, Wo Y, Xu HM, Li XJ, Wang XJ, Ding SJ, Chen XD, He C, Liu LJ, Li H, Yang H, Li TY, Liu W, Cao WC: Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009–2011. PLoS One 2012, 7: e52073. 10.1371\u002Fjournal.pone.0052073\nHan JF, Jiang T, Fan XL, Yang LM, Yu M, Cao RY, Wang JZ, Qin ED, Qin CF: Recombinationof HumanCoxsackievirus B5in Hand, Foot,and Mouth DiseasePatients, China. Emerg Infect Dis 2012, 18: 351-353. 10.3201\u002Feid1802.111524\nHuang YC, Chu YH, Yen TY, Huang WC, Huang LM, Chen AL, Wang HY, Chang LY: Clinical features and phylogenetic analysis of Coxsackievirus A9 in northern Taiwan in 2011. BMC Infect Dis 2013, 13: 33. 10.1186\u002F1471-2334-13-33\nTao Z, Song Y, Li Y, Liu Y, Jiang P, Lin X, Liu G, Song L, Wang H, Xu A: Coxsackievirus B3, Shandong province, China, 1990–2010. Emerg Infect Dis 2012, 18: 1865-1867. 10.3201\u002Feid1811.120090\nChen L, Mou X, Zhang Q, Li Y, Lin F, Yuan L, Tang Y, Xiang C: Detection of human enterovirus 71 and coxsackievirus A16 in children with hand, foot and mouth disease in China. Mol Med Rep 2012, 5: 1001-1004.\nÖsterback R, Vuorinen T, Linna M, Susi P, Hyypiä T, Waris M: Coxsackievirus A6 and hand, foot, and mouth disease, Finland. Emerg Infect Dis 2009, 15: 1485-1488. 10.3201\u002Feid1509.090438\nLo SH, Huang YC, Huang CG, Tsao KC, Li WC, Hsieh YC, Chiu CH, Lin TY: Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009. J Microbiol Immunol Infect 2011, 44: 252-257. 10.1016\u002Fj.jmii.2011.01.031\nBlomqvista S, Klemola P, Kaijalainen S, Paananen A, Simonen ML, Vuorinen T, Roivainena M: Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. J Clin Virol 2010, 48: 49-84. 10.1016\u002Fj.jcv.2010.02.002\nZhu FC, Meng FY, Li JX, Li XL, Mao QY, Tao H, Zhang YT, Yao X, Chu K, Chen QH, Hu YM, Wu X, Liu P, Zhu LY, Gao F, Jin H, Chen YJ, Dong YY, Liang YC, Shi NM, Ge HM, Liu L, Chen SG, Ai X, Zhang ZY, Ji YG, Luo FJ, Chen XQ, Zhang Y, Zhu LW, Liang ZL, Shen XL: Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2013, 381: 2024-2032. 10.1016\u002FS0140-6736(13)61049-1\nNix WA, Oberste MS, Pallansch MA: Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. 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Emerg Microbes Infect. 2017;6 e13–e13.\nKikuti M, Tauro LB, Moreira PSS, et al. Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection. Virol J. 2018;15(1):108. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12985-018-1015-6.\nChouin-Carneiro T, et al. Differential susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika virus. PLoS Negl Trop Dis. 2016;10:e0004543.\nMusso D, Gubler DJ. Zika Virus. Clin Microbiol Rev. 2016;29:487–524.\nBesnard M, Lastère S, Teissier A, Cao-Lormeau V, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Eurosurveillance. 2014;19:20751.\nFoy BD, et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011;17:880–2.\nMuñoz L, Barreras P, Pardo C. Zika virus–associated neurological disease in the adult: Guillain–Barré syndrome, encephalitis, and myelitis. Semin Reprod Med. 2016;34:273–9.\nDe Araújo TVB, et al. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. Lancet Infect Dis. 2018;18:328–36.\nHaby MM, Pinart M, Elias V, Reveiz L. Systematic reviews Prevalence of asymptomatic Zika virus infection: a systematic review. Bull World Heal Organ. 2018;96:402–13.\nGallian P, et al. Zika virus in asymptomatic blood donors in Martinique. Blood. 2017;129:263–6.\nPriyamvada L, Hudson W, Ahmed R, Wrammert J. Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology. Emerg. Microbes Infect. 2017;6:e33.\nL ‘azou M, et al. Dengue Seroprevalence in the French West Indies: a prospective study in adult blood donors. Am J Trop Med Hyg. 2015;92:1137–40.\nGake B, et al. Low seroprevalence of Zika virus in Cameroonian blood donors. Brazilian J Infect Dis. 2017;21:481–3.\nTouret, F. et al. Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone. bioRxiv 272625 (2018). https:\u002F\u002Fdoi.org\u002F10.1101\u002F272625.\nHoldcroft, T. Immunization, Vaccines and Biologicals Guidelines for plaque reduction neutralization testing of human antibodies to dengue viruses. (2007). at \u003Chttp:\u002F\u002Fapps.who.int\u002Firis\u002Fbitstream\u002Fhandle\u002F10665\u002F69687\u002Fwho_ivb_07.07_eng.pdf;jsessionid=DE076FD831D9AC0BC8BAD523E5D3080E?sequence=1>.\nAgbulos DS, Barelli L, Giordano B V., Hunter FF. Zika Virus: Quantification, Propagation, Detection, and Storage. In: Current Protocols in Microbiology. Vol 43. Hoboken: Wiley; 2016:15D.4.1-15D.4.16. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fcpmc.19.\nUpdated Guidance for US Laboratories Testing for Zika Virus Infection. (2017). at \u003Chttp:\u002F\u002Fwww.cdc.gov\u002Fzika\u002Flaboratories.>.\nShan C, et al. Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and dengue virus infection. J Clin Microbiol. 2017;55:3028–36.\nBalmaseda A, et al. Antibody-based assay discriminates Zika virus infection from other flaviviruses. Proc Natl Acad Sci U S A. 2017;114:8384–9.\nDejnirattisai W, et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol. 2016;17:1102–8.\nBraack L, de Almeida AP, Cornel AJ, Swanepoel R, de Jager C. Mosquito-borne arboviruses of African origin: review of key viruses and vectors. Parasit Vectors. 2018;11(1):29. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13071-017-2559-9.\nMüller JA, et al. Development of a high-throughput colorimetric Zika virus infection assay. Med Microbiol Immunol. 2017;206:175–85.\nKoishi AC, et al. Development and evaluation of a novel high-throughput image-based fluorescent neutralization test for detection of Zika virus infection. PLoS Negl Trop Dis. 2018;12:e0006342.\nWilson HL, Tran T, Druce J, Dupont-Rouzeyrol M, Catton M. Neutralization assay for Zika and dengue viruses by use of real-time-PCR-based endpoint assessment. J Clin Microbiol. 2017;55:3104–12.\nShan C, et al. A rapid Zika diagnostic assay to measure neutralizing antibodies in patients. EBioMedicine. 2017;17:157–62.\nSaba Villarroel PM, et al. Zika virus epidemiology in Bolivia: a seroprevalence study in volunteer blood donors. 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Gallian",{"url":2505,"publisher":2724,"properties":2769},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2725,"slug":872,"properties":2726,"entityType":25,"verifyStatus":880,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2729,"manageAffiliations":2738,"indexDatabases":2749,"url":28,"thumbnailPath":28,"statistic":2764,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":2727,"title":2728},{"VOID":875},{"EN":877},[2730,2734],{"id":883,"createTime":28,"updateTime":28,"relativeEntities":2731,"label":2732,"description":2733,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":886},{},{"id":889,"createTime":28,"updateTime":28,"relativeEntities":2735,"label":2736,"description":2737,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":892},{},[2739,2744],{"id":896,"createTime":28,"updateTime":28,"relativeEntities":2740,"slug":28,"properties":2741,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2743,"statistic":28},[],{"title":2742},{"EN":900},[],{"id":903,"createTime":28,"updateTime":28,"relativeEntities":2745,"slug":28,"properties":2746,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2748,"statistic":28},[],{"title":2747},{"EN":907},[],[2750,2757],{"id":911,"indexDatabase":2751,"url":917,"indexYears":918,"academicFieldIds":2756,"indexDatabaseRanking":922},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2752,"label":2753,"description":2754,"key":781,"publicationTags":2755,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[920,921],{"id":924,"indexDatabase":2758,"url":936,"indexYears":28,"academicFieldIds":2763,"indexDatabaseRanking":28},{"id":926,"createTime":28,"updateTime":28,"relativeEntities":2759,"label":2760,"description":2761,"key":933,"publicationTags":2762,"standard":28},[],{"EN":929,"VI":929},{"EN":931,"VI":932},[935,813],[938],{"impactFactor":32,"impactFactorByYear":2765,"i10Index":123,"i10IndexLast5Year":32,"totalPublication":941,"totalPublicationByYear":2766,"totalCitation":951,"totalCitationByYear":2767,"totalCitationPerPublication":116,"totalCitationPerPublicationByYear":2768,"hindexLast5Year":123,"hindex":123},{"2011":106,"2012":421,"2014":32},{"2004":48,"2005":50,"2006":151,"2007":332,"2008":565,"2009":943,"2010":944,"2011":945,"2012":360,"2013":570,"2014":946,"2015":947,"2016":334,"2017":948,"2018":451,"2019":949,"2020":154,"2021":950,"2022":153,"2023":520,"2024":201},{"2010":596,"2012":130},{"2010":342,"2012":54},{"pages":2770,"volume":2771},{"VOID":2244},{"VOID":1861},"2018-12-27",[922,935],{"id":2775,"createTime":2776,"updateTime":2777,"relativeEntities":2778,"slug":2779,"properties":2780,"entityType":971,"verifyStatus":26,"verifyTime":2777,"verifyNote":1296,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":2789,"fullTextUrl":28,"authors":2790,"publicationType":1223,"publisherRelationship":2888,"citationCount":28,"citationInfo":28,"publishDate":2938,"publishYear":2939,"citationAnalyzeStatus":880,"lastCitationAnalyze":28,"indexDatabases":2940,"openAccess":28,"references":28,"isForceReanalyzing":1278},"0169d5d9-4d43-456c-821a-ac792f73533f","2024-01-20T12:57:58.943+00:00","2024-10-03T01:13:13.265+00:00",[],"Potent-and-persistent-antibody-responses-against-the-receptor-binding-domain-of-SARS-CoV-spike-protein-in-recovered-patients",{"abstract":2781,"title":2783,"references":2785,"doi":2787},{"EN":2782},"The spike (S) protein of SARS-CoV not only mediates receptor-binding but also induces neutralizing antibodies. We previously identified the receptor-binding domain (RBD) of S protein as a major target of neutralizing antibodies in animal models and thus proposed a RBD-based vaccine. However, the antigenicity and immunogenicity of RBD in humans need to be characterized. Two panels of serum samples from recovered SARS patients were included and the antibody responses against the RBD were measured by ELISA and micro-neutralization assays. We found that the RBD of S protein induced potent antibody responses in the recovered SARS patients and RBD-specific antibodies could persist at high titers over three year follow-up. Furthermore, affinity purified anti-RBD antibodies possessed robust neutralizing activity. The RBD of SARS-CoV is highly immunogenic in humans and mediates protective responses and RBD-based vaccines and diagnostic approaches can be further developed.",{"EN":2784},"Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients",{"VOID":2786},"Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH, Wang H, Crameri G, Hu Z, Zhang H, et al.: Bats are natural reservoirs of SARS-like coronaviruses. Science 2005, 310: 676-679. 10.1126\u002Fscience.1118391\nRota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, et al.: Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003, 300: 1394-1399. 10.1126\u002Fscience.1085952\nMarra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY, et al.: The Genome sequence of the SARS-associated coronavirus. Science 2003, 300: 1399-1404. 10.1126\u002Fscience.1085953\nLiu S, Xiao G, Chen Y, He Y, Niu J, Escalante CR, Xiong H, Farmar J, Debnath AK, Tien P, Jiang S: Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. Lancet 2004, 363: 938-947. 10.1016\u002FS0140-6736(04)15788-7\nBosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ: Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. Proc Natl Acad Sci USA 2004, 101: 8455-8460. 10.1073\u002Fpnas.0400576101\nSimmons G, Reeves JD, Rennekamp AJ, Amberg SM, Piefer AJ, Bates P: Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc Natl Acad Sci USA 2004, 101: 4240-4245. 10.1073\u002Fpnas.0306446101\nBuchholz UJ, Bukreyev A, Yang L, Lamirande EW, Murphy BR, Subbarao K, Collins PL: Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity. Proc Natl Acad Sci USA 2004, 101: 9804-9809. 10.1073\u002Fpnas.0403492101\nYang ZY, Kong WP, Huang Y, Roberts A, Murphy BR, Subbarao K, Nabel GJ: A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 2004, 428: 561-564. 10.1038\u002Fnature02463\nBisht H, Roberts A, Vogel L, Bukreyev A, Collins PL, Murphy BR, Subbarao K, Moss B: Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice. Proc Natl Acad Sci USA 2004, 101: 6641-6646. 10.1073\u002Fpnas.0401939101\nBukreyev A, Lamirande EW, Buchholz UJ, Vogel LN, Elkins WR, St Claire M, Murphy BR, Subbarao K, Collins PL: Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS. Lancet 2004, 363: 2122-2127. 10.1016\u002FS0140-6736(04)16501-X\nter Meulen J, Bakker AB, van den Brink EN, Weverling GJ, Martina BE, Haagmans BL, Kuiken T, de Kruif J, Preiser W, Spaan W, et al.: Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Lancet 2004, 363: 2139-2141. 10.1016\u002FS0140-6736(04)16506-9\nHe Y, Zhou Y, Wu H, Luo B, Chen J, Li W, Jiang S: Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines. J Immunol 2004, 173: 4050-4057.\nWong SK, Li W, Moore MJ, Choe H, Farzan M: A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem 2004, 279: 3197-3201. 10.1074\u002Fjbc.C300520200\nBabcock GJ, Esshaki DJ, Thomas WD Jr, Ambrosino DM: Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. J Virol 2004, 78: 4552-4560. 10.1128\u002FJVI.78.9.4552-4560.2004\nLi W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, et al.: Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003, 426: 450-454. 10.1038\u002Fnature02145\nHe Y, Lu H, Siddiqui P, Zhou Y, Jiang S: Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies. J Immunol 2005, 174: 4908-4915.\nHe Y, Li J, Li W, Lustigman S, Farzan M, Jiang S: Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein. J Immunol 2006, 176: 6085-6092.\nHe Y, Li J, Heck S, Lustigman S, Jiang S: Antigenic and immunogenic characterization of recombinant baculovirus-expressed severe acute respiratory syndrome coronavirus spike protein: implication for vaccine design. J Virol 2006, 80: 5757-5767. 10.1128\u002FJVI.00083-06\nHe Y, Zhu Q, Liu S, Zhou Y, Yang B, Li J, Jiang S: Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines. Virology 2005, 334: 74-82. 10.1016\u002Fj.virol.2005.01.034\nDu L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S: The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol 2009, 7: 226-236. 10.1038\u002Fnrmicro2090\nHe Y, Jiang S: Vaccine design for severe acute respiratory syndrome coronavirus. Viral Immunol 2005, 18: 327-332. 10.1089\u002Fvim.2005.18.327\nJiang S, He Y, Liu S: SARS vaccine development. Emerg Infect Dis 2005, 11: 1016-1020.\nDu L, Zhao G, Chan CC, Sun S, Chen M, Liu Z, Guo H, He Y, Zhou Y, Zheng BJ, Jiang S: Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity. Virology 2009, 393: 144-150. 10.1016\u002Fj.virol.2009.07.018\nDu L, Zhao G, He Y, Guo Y, Zheng BJ, Jiang S, Zhou Y: Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model. Vaccine 2007, 25: 2832-2838. 10.1016\u002Fj.vaccine.2006.10.031\nDu L, Zhao G, Lin Y, Sui H, Chan C, Ma S, He Y, Jiang S, Wu C, Yuen KY, et al.: Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. J Immunol 2008, 180: 948-956.\nZhu Z, Chakraborti S, He Y, Roberts A, Sheahan T, Xiao X, Hensley LE, Prabakaran P, Rockx B, Sidorov IA, et al.: Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. Proc Natl Acad Sci USA 2007, 104: 12123-12128. 10.1073\u002Fpnas.0701000104\nSui J, Li W, Murakami A, Tamin A, Matthews LJ, Wong SK, Moore MJ, Tallarico AS, Olurinde M, Choe H, et al.: Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc Natl Acad Sci USA 2004, 101: 2536-2541. 10.1073\u002Fpnas.0307140101\nHe Y, Li J, Du L, Yan X, Hu G, Zhou Y, Jiang S: Identification and characterization of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: revealing the critical antigenic determinants in inactivated SARS-CoV vaccine. Vaccine 2006, 24: 5498-5508. 10.1016\u002Fj.vaccine.2006.04.054\nHe Y, Li J, Jiang S: A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity. Biochem Biophys Res Commun 2006, 344: 106-113. 10.1016\u002Fj.bbrc.2006.03.139\nHe Y, Zhou Y, Liu S, Kou Z, Li W, Farzan M, Jiang S: Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine. Biochem Biophys Res Commun 2004, 324: 773-781. 10.1016\u002Fj.bbrc.2004.09.106\nHe Y, Zhou Y, Siddiqui P, Jiang S: Inactivated SARS-CoV vaccine elicits high titers of spike protein-specific antibodies that block receptor binding and virus entry. Biochem Biophys Res Commun 2004, 325: 445-452. 10.1016\u002Fj.bbrc.2004.10.052\nHe Y, Zhou Y, Siddiqui P, Niu J, Jiang S: Identification of immunodominant epitopes on the membrane protein of the severe acute respiratory syndrome-associated coronavirus. J Clin Microbiol 2005, 43: 3718-3726. 10.1128\u002FJCM.43.8.3718-3726.2005\nHe Y, Zhou Y, Wu H, Kou Z, Liu S, Jiang S: Mapping of antigenic sites on the nucleocapsid protein of the severe acute respiratory syndrome coronavirus. J Clin Microbiol 2004, 42: 5309-5314. 10.1128\u002FJCM.42.11.5309-5314.2004\nDu L, Zhao G, Lin Y, Chan C, He Y, Jiang S, Wu C, Jin DY, Yuen KY, Zhou Y, Zheng BJ: Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection. Vaccine 2008, 26: 1644-1651. 10.1016\u002Fj.vaccine.2008.01.025\nWu LP, Wang NC, Chang YH, Tian XY, Na DY, Zhang LY, Zheng L, Lan T, Wang LF, Liang GD: Duration of antibody responses after severe acute respiratory syndrome. Emerg Infect Dis 2007, 13: 1562-1564.\nCao WC, Liu W, Zhang PH, Zhang F, Richardus JH: Disappearance of antibodies to SARS-associated coronavirus after recovery. N Engl J Med 2007, 357: 1162-1163. 10.1056\u002FNEJMc070348",{"VOID":2788},"10.1186\u002F1743-422X-7-299","https:\u002F\u002Fvirologyj.biomedcentral.com\u002Farticles\u002F10.1186\u002F1743-422X-7-299",[2791,2806,2821,2836,2849,2862,2875],{"id":2792,"sortIndex":32,"researcher":28,"roles":2793,"affiliations":2794,"properties":2803},"c936956f-f2f2-4490-a7ad-a16670316351",[977],[2795],{"id":2796,"sortIndex":32,"affiliation":2797,"properties":28},"d2001093-0471-448d-b6bf-86e423f10b56",{"id":2796,"createTime":28,"updateTime":28,"relativeEntities":2798,"slug":28,"properties":2799,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2802,"statistic":28},[],{"title":2800},{"VI":2801},"State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China",[],{"title":2804},{"VI":2805},"Zhiliang Cao",{"id":2807,"sortIndex":40,"researcher":28,"roles":2808,"affiliations":2809,"properties":2818},"209ab583-e8d6-46b4-a574-b4e285ba2fe5",[977],[2810],{"id":2811,"sortIndex":32,"affiliation":2812,"properties":28},"8ccb689d-f00b-46a0-8f72-55931cc2bd1c",{"id":2811,"createTime":28,"updateTime":28,"relativeEntities":2813,"slug":28,"properties":2814,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2817,"statistic":28},[],{"title":2815},{"VI":2816},"Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China",[],{"title":2819},{"VI":2820},"Lifeng Liu",{"id":2822,"sortIndex":123,"researcher":28,"roles":2823,"affiliations":2824,"properties":2833},"8dca4cd9-4cda-4207-ab0f-dcf43b49792a",[977],[2825],{"id":2826,"sortIndex":32,"affiliation":2827,"properties":28},"12235c8d-64fd-44f8-ae11-7e7635016ae1",{"id":2826,"createTime":28,"updateTime":28,"relativeEntities":2828,"slug":28,"properties":2829,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2832,"statistic":28},[],{"title":2830},{"VI":2831},"Lindsley F. Kimball Research Institute, New York Blood Center, New York, USA",[],{"title":2834},{"VI":2835},"Lanying Du",{"id":2837,"sortIndex":42,"researcher":28,"roles":2838,"affiliations":2839,"properties":2846},"43e9845a-200f-4ff5-991b-fa1f1e65bc96",[977],[2840],{"id":2796,"sortIndex":32,"affiliation":2841,"properties":28},{"id":2796,"createTime":28,"updateTime":28,"relativeEntities":2842,"slug":28,"properties":2843,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2845,"statistic":28},[],{"title":2844},{"VI":2801},[],{"title":2847},{"VI":2848},"Chao 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reproductive and respiratory syndrome virus (PRRSV) is a macrophage-tropic arterivirus with extremely high genetic and pathogenic heterogeneity that causes significant economic losses in the swine industry worldwide. PRRSV can be divided into two species [PRRSV1 (European) and PRRSV2 (North American)] and is usually diagnosed and genetically differentiated into several lineages based on the ORF5 gene, which constitutes only 5% of the whole genome. This study was conducted to achieve nonselective amplification and whole-genome sequencing (WGS) based on a simplified sequence-independent, single-primer amplification (SISPA) technique with next-generation sequencing (NGS), and to genetically characterize Korean PRRSV field isolates at the whole genome level. The SISPA-NGS method coupled with a bioinformatics pipeline was utilized to retrieve full length PRRSV genomes of 19 representative Korean PRRSV strains by de novo assembly. Phylogenetic analysis, analysis of the insertion and deletion (INDEL) pattern of nonstructural protein 2 (NSP2), and recombination analysis were conducted. Nineteen complete PRRSV genomes were obtained with a high depth of coverage by the SISPA-NGS method. Korean PRRSV1 belonged to the Korean-specific subtype 1A and vaccine-related subtype 1C lineages, showing no evidence of recombination and divergent genetic heterogeneity with conserved NSP2 deletion patterns. Among Korean PRRSV2 isolates, modified live vaccine (MLV)-related lineage 5 viruses, lineage 1 viruses, and nation-specific Korean lineages (KOR A, B and C) could be identified. The NSP2 deletion pattern of the Korean lineages was consistent with that of the MN-184 strain (lineage 1), which indicates the common ancestor and independent evolution of Korean lineages. Multiple recombination signals were detected from Korean-lineage strains isolated in the 2010s, suggesting natural interlineage recombination between circulating KOR C and MLV strains. Interestingly, the Korean strain GGYC45 was identified as a recombinant KOR C and MLV strain harboring the KOR B ORF5 gene and might be the ancestor of currently circulating KOR B strains. Additionally, two novel lineage 1 recombinants of NADC30-like and NADC34-like viruses were detected. Genome-wide analysis of Korean PRRSV isolates retrieved by the SISPA-NGS method and de novo assembly, revealed complex evolution and recombination in the field. Therefore, continuous surveillance of PRRSV at the whole genome level should be conducted, and new vaccine strategies for more efficient control of the virus are needed.",{"EN":2951},"Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea",{"VOID":2953},"Keffaber K. Reproduction failure of unknown etiology. Am Assoc Swine Pract Newsl. 1989;1:1–9.\nHoltkamp DJ, Kliebenstein JB, Neumann E, Zimmerman JJ, Rotto H, Yoder TK, Wang C, Yeske P, Mowrer CL, Haley CA. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. 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Virus Genes. 2020;56:354–60.",{"VOID":2955},"10.1186\u002Fs12985-022-01790-6","https:\u002F\u002Fvirologyj.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12985-022-01790-6",[2958,2973,2986,3008,3021,3034,3047,3060,3073,3086,3099,3112],{"id":2959,"sortIndex":32,"researcher":28,"roles":2960,"affiliations":2961,"properties":2970},"99b37348-64ec-4663-aca8-f0ad732fd3c9",[977],[2962],{"id":2963,"sortIndex":32,"affiliation":2964,"properties":28},"795bbe27-8a34-4fcd-8318-bf17beff849b",{"id":2963,"createTime":28,"updateTime":28,"relativeEntities":2965,"slug":28,"properties":2966,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2969,"statistic":28},[],{"title":2967},{"VI":2968},"College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea",[],{"title":2971},{"VI":2972},"Seung-Chai Kim",{"id":2974,"sortIndex":40,"researcher":28,"roles":2975,"affiliations":2976,"properties":2983},"7f21a0cc-d25b-4892-81a0-98eb58b36c9c",[977],[2977],{"id":2963,"sortIndex":32,"affiliation":2978,"properties":28},{"id":2963,"createTime":28,"updateTime":28,"relativeEntities":2979,"slug":28,"properties":2980,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2982,"statistic":28},[],{"title":2981},{"VI":2968},[],{"title":2984},{"VI":2985},"Sung-Hyun Moon",{"id":2987,"sortIndex":123,"researcher":28,"roles":2988,"affiliations":2989,"properties":3005},"6a4659e6-9bcd-449a-a733-a797de3a18f7",[977],[2990,2996],{"id":2963,"sortIndex":32,"affiliation":2991,"properties":28},{"id":2963,"createTime":28,"updateTime":28,"relativeEntities":2992,"slug":28,"properties":2993,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2995,"statistic":28},[],{"title":2994},{"VI":2968},[],{"id":2997,"sortIndex":40,"affiliation":2998,"properties":3004},"db98d016-eca0-4667-b4f0-9aab26ad0504",{"id":2997,"createTime":28,"updateTime":28,"relativeEntities":2999,"slug":28,"properties":3000,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3003,"statistic":28},[],{"title":3001},{"VI":3002},"Animal and Plant Quarantine Agency, Gimcheon, Korea",[],{},{"title":3006},{"VI":3007},"Chang-Gi Jeong",{"id":3009,"sortIndex":42,"researcher":28,"roles":3010,"affiliations":3011,"properties":3018},"bfc75d4b-d6f7-4fdf-b1e6-543b50ef861e",[977],[3012],{"id":2963,"sortIndex":32,"affiliation":3013,"properties":28},{"id":2963,"createTime":28,"updateTime":28,"relativeEntities":3014,"slug":28,"properties":3015,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3017,"statistic":28},[],{"title":3016},{"VI":2968},[],{"title":3019},{"VI":3020},"Gyeong-Seo Park",{"id":3022,"sortIndex":45,"researcher":28,"roles":3023,"affiliations":3024,"properties":3031},"c5f94161-44a5-458f-9cc0-5bcc454ff18f",[977],[3025],{"id":2997,"sortIndex":32,"affiliation":3026,"properties":28},{"id":2997,"createTime":28,"updateTime":28,"relativeEntities":3027,"slug":28,"properties":3028,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3030,"statistic":28},[],{"title":3029},{"VI":3002},[],{"title":3032},{"VI":3033},"Ji-Young Park",{"id":3035,"sortIndex":46,"researcher":28,"roles":3036,"affiliations":3037,"properties":3044},"d8617381-ead1-43b8-a860-be06ca47745c",[977],[3038],{"id":2997,"sortIndex":32,"affiliation":3039,"properties":28},{"id":2997,"createTime":28,"updateTime":28,"relativeEntities":3040,"slug":28,"properties":3041,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3043,"statistic":28},[],{"title":3042},{"VI":3002},[],{"title":3045},{"VI":3046},"Hye-Young Jeoung",{"id":3048,"sortIndex":48,"researcher":28,"roles":3049,"affiliations":3050,"properties":3057},"680cab25-675c-4867-a666-e630388ca7ae",[977],[3051],{"id":2997,"sortIndex":32,"affiliation":3052,"properties":28},{"id":2997,"createTime":28,"updateTime":28,"relativeEntities":3053,"slug":28,"properties":3054,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3056,"statistic":28},[],{"title":3055},{"VI":3002},[],{"title":3058},{"VI":3059},"Go-Eun Shin",{"id":3061,"sortIndex":49,"researcher":28,"roles":3062,"affiliations":3063,"properties":3070},"74a51950-5bf3-46ee-8571-a75e2e448112",[977],[3064],{"id":2997,"sortIndex":32,"affiliation":3065,"properties":28},{"id":2997,"createTime":28,"updateTime":28,"relativeEntities":3066,"slug":28,"properties":3067,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3069,"statistic":28},[],{"title":3068},{"VI":3002},[],{"title":3071},{"VI":3072},"Mi-Kyeong 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high-risk human papillomavirus (HR-HPV) infection is an important factor in the development of cervical cancer, and human papillomavirus type 16 (HPV-16) is the most common HR-HPV type worldwide. The oncogenic potential of HPV-16 is closely related to viral sequence variation. In order to clarify the variant characteristics of HPV-16 E6 and E7 genes in central China, E6 and E7 sequences of 205 HPV‐16 positive samples were amplified by polymerase chain reaction. PCR products of E6 and E7 genes were further sequenced and subjected to variation analysis, phylogenetic analysis, selective pressure analysis and B-cell epitope prediction. Twenty-six single nucleotide variants were observed in E6 sequence, including 21 non-synonymous and 5 synonymous variants. Twelve single nucleotide variants were identified in E7 sequence, including 6 non-synonymous and 6 synonymous variants. Four new variants were found. Furthermore, nucleotide variation A647G (N29S) in E7 was significantly related to the higher risk of HSIL and cervical cancer. Phylogenetic analysis showed that the E6 and E7 sequences were all distributed in A lineage. No positively selected site was found in HPV-16 E6 and E7 sequences. Non-conservative substitutions in E6, H31Y, D32N, D32E, I34M, L35V, E36Q, L45P, N65S and K75T, affected multiple B-cell epitopes. However, the variation of E7 gene had little impact on the corresponding B-cell epitopes (score \u003C 0.85). HPV-16 E6 and E7 sequences variation data may contribute to HR-HPV prevention and vaccine development in Jingzhou, central China.",{"EN":3187},"Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China",{"VOID":3189},"Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2007;370(9590):890–907.\nCohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169–82.\nChen Q, Yao L, Wu Q, Xu J, Yan C, Guo C, et al. Rapid and simultaneous visual typing of high-risk HPV-16\u002F18 with use of integrated lateral flow strip platform. Mikrochim Acta. 2022;189(9):350.\nPiña-Sánchez P. Human papillomavirus: challenges and opportunities for the control of cervical cancer. Arch Med Res. 2022;53(8):753–69.\nHoppe-Seyler K, Bossler F, Braun JA, Herrmann AL, Hoppe-Seyler F. The HPV E6\u002FE7 oncogenes: key factors for viral carcinogenesis and therapeutic targets. Trends Microbiol. 2018;26(2):158–68.\nMuñoz-Bello JO, Carrillo-García A, Lizano M. Epidemiology and molecular biology of HPV variants in cervical cancer: the state of the art in Mexico. Int J Mol Sci. 2022;23(15):8566.\nAsensio-Puig L, Alemany L, Pavón MA. A straightforward HPV16 lineage classification based on machine learning. Front Artif Intell. 2022;5:851841.\nCornet I, Gheit T, Iannacone MR, Vignat J, Sylla BS, Del Mistro A, et al. HPV16 genetic variation and the development of cervical cancer worldwide. Br J Cancer. 2013;108(1):240–4.\nZhou Z, Yang H, Yang L, Yao Y, Dai S, Shi L, et al. Human papillomavirus type 16 E6 and E7 gene variations associated with cervical cancer in a Han Chinese population. Infect Genet Evol. 2019;73:13–20.\nGheit T, Cornet I, Clifford GM, Iftner T, Munk C, Tommasino M, et al. Risks for persistence and progression by human papillomavirus type 16 variant lineages among a population-based sample of Danish women. Cancer Epidemiol Biomark Prev. 2011;20(7):1315–21.\nMirabello L, Yeager M, Cullen M, Boland JF, Chen Z, Wentzensen N, et al. HPV16 sublineage associations with histology-specific cancer risk using HPV whole-genome sequences in 3200 women. J Natl Cancer Inst. 2016;108(9):djw100.\nMatsumoto K, Yoshikawa H, Nakagawa S, Tang X, Yasugi T, Kawana K, et al. Enhanced oncogenicity of human papillomavirus type 16 (HPV16) variants in Japanese population. Cancer Lett. 2000;156(2):159–65.\nZine El Abidine A, Tomaić V, Bel Haj Rhouma R, Massimi P, Guizani I, Boubaker S, et al. A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site. Virology. 2017;500:218–25.\nEschle D, Dürst M, ter Meulen J, Luande J, Eberhardt HC, Pawlita M, et al. Geographical dependence of sequence variation in the E7 gene of human papillomavirus type 16. J Gen Virol. 1992;73(Pt 7):1829–32.\nTang SY, Liao YQ, Hu Y, Shen HY, Wan YP, Wu YM. HPV Prevalence and genotype distribution among women from Hengyang district of Hunan province, China. Front Public Health. 2021;9:710209.\nOyouni AAA. Human papillomavirus in cancer: infection, disease transmission, and progress in vaccines. J Infect Public Health. 2023;16(4):626–31.\nMirabello L, Clarke MA, Nelson CW, Dean M, Wentzensen N, Yeager M, et al. The intersection of HPV epidemiology, genomics and mechanistic Studies of HPV-mediated carcinogenesis. Viruses. 2018;10(2):80.\nDeFilippis VR, Ayala FJ, Villarreal LP. Evidence of diversifying selection in human papillomavirus type 16 E6 but not E7 oncogenes. J Mol Evol. 2002;55(4):491–9.\nYang Z. Maximum likelihood estimation on large phylogenies and analysis of adaptive evolution in human influenza virus A. J Mol Evol. 2000;51(5):423–32.\nBedell SL, Goldstein LS, Goldstein AR, Goldstein AT. Cervical cancer screening: past, present, and future. Sex Med Rev. 2020;8(1):28–37.\nXia C, Li S, Long T, Chen Z, Chan PKS, Boon SS. Current updates on cancer-causing types of human papillomaviruses (HPVs) in east, southeast, and south Asia. Cancers (Basel). 2021;13(11):2691.\nWang Q, Song R, Zhao C, Liu H, Yang Y, Gu S, et al. HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. Int J Cancer. 2019;144(7):1619–32.\nAi W, Wu C, Jia L, Xiao X, Xu X, Ren M, et al. Deep sequencing of HPV16 E6 region reveals unique mutation pattern of HPV16 and predicts cervical cancer. Microbiol Spectr. 2022;10(4):e0140122.\nBao HL, Jin C, Wang S, Song Y, Xu ZY, Yan XJ, et al. Prevalence of cervicovaginal human papillomavirus infection and genotypes in the pre-vaccine era in China: a nationwide population-based study. J Infect. 2021;82(4):75–83.\nLi K, Li Q, Song L, Wang D, Yin R. The distribution and prevalence of human papillomavirus in women in mainland China. Cancer. 2019;125(7):1030–7.\nZhu X, Wang Y, Lv Z, Su J. Prevalence and genotype distribution of high-risk HPV infection among women in Beijing, China. J Med Virol. 2021;93(8):5103–9.\nYang Z, Zhang C, Luo P, Ye M, Gong Q, Mei B. Genetic variability of E6 and E7 genes of human papillomavirus type 58 in Jingzhou, Hubei Province of central China. Virol J. 2022;19(1):71.\nZheng Y, Li X, Jiao Y, Wu C. High-risk human papillomavirus oncogenic E6\u002FE7 mRNAs splicing regulation. Front Cell Infect Microbiol. 2022;12:929666.\nXi LF, Schiffman M, Koutsky LA, Hughes JP, Hulbert A, Shen Z, et al. Variant-specific persistence of infections with human papillomavirus types 31, 33, 45, 56 and 58 and risk of cervical intraepithelial neoplasia. Int J Cancer. 2016;139(5):1098–105.\nChoi BS, Kim SS, Yun H, Jang DH, Lee JS. Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers. J Med Virol. 2007;79(4):426–30.\nPande S, Jain N, Prusty BK, Bhambhani S, Gupta S, Sharma R, et al. Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in north India. J Clin Microbiol. 2008;46(3):1060–6.\nZhe X, Xin H, Pan Z, Jin F, Zheng W, Li H, et al. Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China. Cancer Cell Int. 2019;19:65.\nShang Q, Wang Y, Fang Y, Wei L, Chen S, Sun Y, et al. Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in identification of cervical carcinomas in patients in northeast China. J Clin Microbiol. 2011;49(7):2656–63.\nDai MZ, Qiu Y, Di XH, Shi WW, Xu HH. Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China. BMC Cancer. 2021;21(1):769.\nBletsa G, Zagouri F, Amoutzias GD, Nikolaidis M, Zografos E, Markoulatos P, et al. Genetic variability of the HPV16 early genes and LCR. Present and future perspectives. Expert Rev Mol Med. 2021;23:e19.\nAndersson S, Alemi M, Rylander E, Strand A, Larsson B, Sällström J, et al. Uneven distribution of HPV 16 E6 prototype and variant (L83V) oncoprotein in cervical neoplastic lesions. Br J Cancer. 2000;83(3):307–10.\nZhao J, Zhan Q, Guo J, Liu M, Ruan Y, Zhu T, et al. Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai. Infect Agent Cancer. 2019;14:38.\nMandal P, Bhattacharjee B, Sen S, Bhattacharya A, Saha SS, Chowdhury RR, et al. Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes. Transl Oncol. 2022;15(1):101256.\nClifford GM, Tenet V, Georges D, Alemany L, Pavón MA, Chen Z, et al. Human papillomavirus 16 sub-lineage dispersal and cervical cancer risk worldwide: Whole viral genome sequences from 7116 HPV16-positive women. Papillomavirus Res. 2019;7:67–74.\nZhao J, Zhu J, Guo J, Zhu T, Zhong J, Liu M, et al. Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women. J Med Virol. 2020;92(3):372–81.\nGalati L, Equestre M, Bruni R, Accardi L, Torti C, Fiorillo MT, et al. Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears. Infect Genet Evol. 2019;68:185–93.\nLiu Y, Pan Y, Gao W, Ke Y, Lu Z. Whole-genome analysis of human papillomavirus types 16, 18, and 58 isolated from cervical precancer and cancer samples in Chinese women. Sci Rep. 2017;7(1):263.\nZhang Y, Cao M, Wang M, Ding X, Jing Y, Chen Z, et al. Genetic variability in E6, E7, and L1 genes of human papillomavirus genotype 52 from Southwest China. Gene. 2016;585(1):110–8.\nTsakogiannis D, Papadopoulou A, Kontostathi G, Ruether IGA, Kyriakopoulou Z, Dimitriou TG, et al. Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women. J Med Microbiol. 2013;62(Pt 11):1688–96.\nYang L, Yang H, Wu K, Shi X, Ma S, Sun Q. Prevalence of HPV and variation of HPV 16\u002FHPV 18 E6\u002FE7 genes in cervical cancer in women in South West China. J Med Virol. 2014;86(11):1926–36.\nWang R, Pan W, Jin L, Huang W, Li Y, Wu D, et al. Human papillomavirus vaccine against cervical cancer: opportunity and challenge. Cancer Lett. 2020;471:88–102.\nHe J, Yang Y, Chen Z, Liu Y, Bao S, Zhao Y, et al. Identification of variants and therapeutic epitopes in HPV-33\u002FHPV-58 E6 and E7 in Southwest China. Virol J. 2019;16(1):72.",{"VOID":3191},"10.1186\u002Fs12985-023-02188-8","https:\u002F\u002Fvirologyj.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12985-023-02188-8",[3194,3209,3222,3235,3248],{"id":3195,"sortIndex":32,"researcher":28,"roles":3196,"affiliations":3197,"properties":3206},"dd74449e-69e7-4551-ac30-25be207e2f05",[977],[3198],{"id":3199,"sortIndex":32,"affiliation":3200,"properties":28},"1c9da570-7c9a-4691-860f-2c6d2965dd4b",{"id":3199,"createTime":28,"updateTime":28,"relativeEntities":3201,"slug":28,"properties":3202,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3205,"statistic":28},[],{"title":3203},{"VI":3204},"Department of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, China",[],{"title":3207},{"VI":3208},"Ting 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