[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_b5209d2b-2258-40ef-8732-874e80fe24a5":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:b5209d2b-2258-40ef-8732-874e80fe24a5,\"}":90},{"code":4,"data":5,"meta":25},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":26,"subjectFields":27,"manageAffiliations":28,"indexDatabases":29,"url":43,"thumbnailPath":25,"statistic":44,"gsStatistic":78,"type":89,"analyzePriority":25},"b5209d2b-2258-40ef-8732-874e80fe24a5","2023-08-01T04:13:30.887+00:00","2026-08-27T01:57:29.562+00:00",[],"VNU-Journal-of-Science-Medical-and-Pharmaceutical-Sciences",{"country":12,"eissn":14,"issn":16,"title":18,"gsId":20},{"VOID":13},"VN",{"VOID":15},"25881132",{"VOID":17},"26159309",{"EN":19},"VNU Journal of Science: Medical and Pharmaceutical Sciences",{"VOID":21},"nxupvWQAAAAJ","PUBLISHER","VERIFIED","2023-08-01T04:16:22.633+00:00",null,31,[],[],[30],{"id":31,"indexDatabase":32,"url":42,"indexYears":25,"academicFieldIds":25,"indexDatabaseRanking":25},"1c684ac3-c7bf-4466-8841-3c6146083c3c",{"id":33,"createTime":25,"updateTime":25,"relativeEntities":34,"label":35,"description":37,"key":39,"publicationTags":40,"standard":25},"7c6668cf-5dbb-472f-ac65-0e3d0d95e1c2",[],{"EN":36,"VI":36},"ACI - Asean Citation Index",{"EN":38,"VI":38},"Cơ sở dữ liệu ACI","aci",[41],"ACI","https:\u002F\u002Fasean-cites.org\u002Fjournal_info?jid=11969","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS",{"impactFactor":45,"impactFactorByYear":46,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":52,"totalPublicationByYear":53,"totalCitation":62,"totalCitationByYear":63,"totalCitationPerPublication":69,"totalCitationPerPublicationByYear":70,"hindexLast5Year":77,"hindex":77},0,{"2019":47,"2020":48,"2021":49,"2022":49,"2023":50,"2024":51},0.05,0.14,0.12,0.15,0.1,360,{"2016":54,"2017":55,"2018":56,"2019":57,"2020":58,"2021":59,"2022":60,"2023":61,"2024":59},26,34,29,30,48,47,49,50,163,{"2016":64,"2017":64,"2018":65,"2019":54,"2020":66,"2021":65,"2022":67,"2023":68},9,21,53,18,6,0.45,{"2016":71,"2017":72,"2018":73,"2019":74,"2020":75,"2021":69,"2022":76,"2023":49},0.35,0.26,0.72,0.87,1.1,0.37,4,{"impactFactor":25,"impactFactorByYear":25,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":79,"totalPublicationByYear":80,"totalCitation":84,"totalCitationByYear":85,"totalCitationPerPublication":87,"totalCitationPerPublicationByYear":88,"hindexLast5Year":81,"hindex":86},24,{"0":81,"2014":82,"2015":82,"2016":83},2,1,20,17,{"2016":82,"2019":81,"2021":81,"2023":77,"2024":86,"2025":82,"2026":82},3,0.71,{"2016":47},"JOURNAL",{"meta":91,"data":93},{"total":92},"429",[94,202,291,405,498,601,670,773,847,933],{"id":95,"createTime":96,"updateTime":97,"relativeEntities":98,"slug":99,"properties":100,"entityType":109,"verifyStatus":23,"verifyTime":110,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":86,"primaryUrl":112,"fullTextUrl":113,"authors":114,"publicationType":160,"publisherRelationship":161,"citationCount":25,"citationInfo":25,"publishDate":196,"publishYear":197,"citationAnalyzeStatus":198,"lastCitationAnalyze":199,"indexDatabases":200,"openAccess":25,"references":25,"isForceReanalyzing":201},"d9f4c3ca-802e-475a-bd9f-f01f620259f6","2023-08-03T06:20:59.437+00:00","2026-08-20T03:37:10.367+00:00",[],"-Clinical-Signs-of-Temporomandibular-Joint-Dysfunction-in-Students-of-a-University-in-Hanoi",{"abstract":101,"title":103,"gsPaper":105,"doi":107},{"EN":102},"Abstract: Temporomandibular joint dysfunction (TMD) is a common disease, especially increasing in young people, and affects the quality of life. Clinical signs of TMDs are various and complex. Diagnosis of symptoms and prognosis is essential. Therefore, we conducted a cross-sectional descriptive study on 61 patients aged 19-23 who participated voluntarily from February to June 2022 at the Odonto-Stomatology clinic at the University of Medicine and Pharmacy, Vietnam National University. The results showed that the proportion of women with symptoms was higher than that of men. For the clinical symptoms, percentages of the limited range of mandibular movements and mouth gap deviation were quite high (77.0% and 68.9%, respectively). Joint sounds and arthralgia took 31.1% and 24.6%, while myalgia accounted for only 11.5%. In the joint, the pain was detected mainly on the outer surface of the joint (24.6%). In both genders, the masseter muscle was the most painful muscle group. Clinical symptoms are very important in diagnosis, treatment, and prognosis.\r\nKeywords: Clinical signs, temporomandibular joint dysfunction, students. \r\n \r\n ",{"VI":104}," Clinical Signs of Temporomandibular Joint Dysfunction  in Students of a University in Hanoi",{"VOID":106},"17179959216878065094",{"VOID":108},"10.25073\u002F2588-1132\u002Fvnumps.4451","PUBLICATION","2023-08-03T06:20:59.436+00:00","65143","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4451","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4451\u002F4055",[115,122,129,136,153],{"id":116,"sortIndex":45,"researcher":25,"roles":117,"affiliations":118,"properties":119,"displayName":121,"givenName":25,"familyName":25},"628feb87-4bc0-46dd-8f71-e4b732e815a8",[],[],{"title":120},{"VI":121},"Nguyen Thi Minh 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39 No. 1","Tập 39 Số 1",{"VOID":195},"39","2023-03-25",2023,"PENDING","2025-11-21T15:24:44.731+00:00",[41],false,{"id":203,"createTime":204,"updateTime":205,"relativeEntities":206,"slug":207,"properties":208,"entityType":109,"verifyStatus":23,"verifyTime":217,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":82,"primaryUrl":218,"fullTextUrl":219,"authors":220,"publicationType":160,"publisherRelationship":249,"citationCount":45,"citationInfo":284,"publishDate":287,"publishYear":285,"citationAnalyzeStatus":288,"lastCitationAnalyze":289,"indexDatabases":290,"openAccess":25,"references":25,"isForceReanalyzing":201},"150d6031-fe0d-41c7-9212-4569f942e25b","2023-08-03T06:55:37.663+00:00","2026-08-20T03:37:10.345+00:00",[],"-Characteristics-of-Clinical-and-Magnetic-Resonance-and-Treatment-Result-for-Anterior-Cruciate-Ligament-Tear-of-the-Knee-Joint",{"abstract":209,"title":211,"gsPaper":213,"doi":215},{"EN":210},"Study on 41 patients with anterior cruciate ligament rupture diagnosed and treated at E Hospital from March 2021 to April 2022 showed: Mean age: 36.02, Male: 68.3%, female: 27.7%. Traffic accidents: 65.9%. Right foot: 53.7%, left foot: 44.3%. Timefrom injury to treatment > 3 weeks: 70.7%. Clinical: loose knee: 90.2%; pain: 87.8%; difficulty going up and down stairs: 65.9%; knee swelling: 51.2%; effusion: 68.3%; front drawer: 95.1%; Lachman: 92.7%; McMurray: 41.4%; average Lysholm score: 60.88. Magnetic resonance imaging (MRI): decompression\u002Fintermittent: complete: 52.7%, partial: 46.3%; contusion, edema: 41.5%; hematoma-hemorrhage: 87.7%; bone marrow edema: 34.1%; meniscus tear: 46.3%. Treatment results: pain relief upon discharge: 70.7%; incision: dry: 56.1% drainage: 43.9%, infection: 0, after follow-up: mean Lysholm score: 86.95, complications: numbness, burning behind the thigh: 2.44%.",{"EN":212}," Characteristics of Clinical and Magnetic Resonance,  and Treatment Result for Anterior Cruciate Ligament Tear  of the Knee Joint",{"VOID":214},"12218438961601618713",{"VOID":216},"10.25073\u002F2588-1132\u002Fvnumps.4407","2023-08-03T06:55:37.661+00:00","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4407","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4407\u002F4000",[221,242],{"id":222,"sortIndex":45,"researcher":25,"roles":223,"affiliations":224,"properties":239,"displayName":241,"givenName":25,"familyName":25},"056a1501-50af-4022-913c-86528aa5d169",[],[225],{"id":226,"sortIndex":45,"affiliation":227,"properties":236},"91a71f5e-4426-4306-b25d-c2754637789a",{"id":226,"createTime":25,"updateTime":25,"relativeEntities":228,"slug":25,"properties":229,"entityType":25,"verifyStatus":25,"verifyTime":25,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":25,"url":25,"parentIds":234,"statistic":25},[],{"title":230,"country":233},{"EN":231,"VI":232},"VNU University of Medicine and Pharmacy","Trường Đại học Y Dược, Đại học Quốc gia Hà Nội",{"VOID":13},[235],"12466116-8f60-4b01-8faf-2411483a0977",{"title":237},{"VI":238},"Trường Đại học Y Dược- Đại Học Quốc gia Hà Nội",{"title":240},{"VI":241},"Pham Thi Minh Ngoc",{"id":243,"sortIndex":45,"researcher":25,"roles":244,"affiliations":245,"properties":246,"displayName":248,"givenName":25,"familyName":25},"89404934-ceb4-4c12-9e63-c7d21cf43aa0",[],[],{"title":247},{"VI":248},"Nguyen Van Son",{"url":218,"publisher":250,"properties":276},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":251,"slug":10,"properties":252,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":26,"subjectFields":258,"manageAffiliations":259,"indexDatabases":260,"url":43,"thumbnailPath":25,"statistic":267,"gsStatistic":272,"type":89,"analyzePriority":25},[],{"country":253,"eissn":254,"issn":255,"title":256,"gsId":257},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},{"VOID":21},[],[],[261],{"id":31,"indexDatabase":262,"url":42,"indexYears":25,"academicFieldIds":25,"indexDatabaseRanking":25},{"id":33,"createTime":25,"updateTime":25,"relativeEntities":263,"label":264,"description":265,"key":39,"publicationTags":266,"standard":25},[],{"EN":36,"VI":36},{"EN":38,"VI":38},[41],{"impactFactor":45,"impactFactorByYear":268,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":52,"totalPublicationByYear":269,"totalCitation":62,"totalCitationByYear":270,"totalCitationPerPublication":69,"totalCitationPerPublicationByYear":271,"hindexLast5Year":77,"hindex":77},{"2019":47,"2020":48,"2021":49,"2022":49,"2023":50,"2024":51},{"2016":54,"2017":55,"2018":56,"2019":57,"2020":58,"2021":59,"2022":60,"2023":61,"2024":59},{"2016":64,"2017":64,"2018":65,"2019":54,"2020":66,"2021":65,"2022":67,"2023":68},{"2016":71,"2017":72,"2018":73,"2019":74,"2020":75,"2021":69,"2022":76,"2023":49},{"impactFactor":25,"impactFactorByYear":25,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":79,"totalPublicationByYear":273,"totalCitation":84,"totalCitationByYear":274,"totalCitationPerPublication":87,"totalCitationPerPublicationByYear":275,"hindexLast5Year":81,"hindex":86},{"0":81,"2014":82,"2015":82,"2016":83},{"2016":82,"2019":81,"2021":81,"2023":77,"2024":86,"2025":82,"2026":82},{"2016":47},{"issue":277,"title":279,"volume":282},{"VOID":278},"2",{"EN":280,"VI":281},"Vol. 38 No. 2","Tập 38 Số 2",{"VOID":283},"38",{"total":45,"publishYear":285,"statisticByYear":286},2022,{},"2022-06-24","ERROR_IN_ANALYZE_CITATION","2026-05-27T08:00:46.023+00:00",[41],{"id":292,"createTime":293,"updateTime":294,"relativeEntities":295,"slug":296,"properties":297,"entityType":109,"verifyStatus":23,"verifyTime":306,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":45,"primaryUrl":307,"fullTextUrl":308,"authors":309,"publicationType":160,"publisherRelationship":366,"citationCount":25,"citationInfo":25,"publishDate":401,"publishYear":402,"citationAnalyzeStatus":288,"lastCitationAnalyze":403,"indexDatabases":404,"openAccess":25,"references":25,"isForceReanalyzing":201},"10f24947-ab16-4743-9657-ca37fe5b3f5a","2023-08-03T06:31:29.430+00:00","2026-08-20T03:37:10.305+00:00",[],"-Anti-inflammatory-and-Antioxidant-Activities-of-Symplocos-cochinchinensis-Lour-Moore-ssp-Laurina-Retz-Nooteb-Leaf-Extract",{"abstract":298,"title":300,"gsPaper":302,"doi":304},{"EN":299},"Symplocos cochinchinensis (S.  cochinchinensis) leaves have been used by Vietnamese in herbal medicines to support the treatment of infirmities. The purpose of this study was to determine some phytochemicals, assess in vitro anti-inflammatory and antioxidant capacities of  S. cochinchinensis leaf extract to provide information for further research. The study results show that S. cochinchinensis leaves contain polyphenols, flavonoids, and saponins by chemical reactions and thin layer chromatography profiling. The total polyphenol, flavonoid, and saponin contents were 517.71 ± 19.50 mg GAE\u002Fg d. w., 1.12 ± 0.01 mg QE\u002Fg d. w., and 32.18 ± 0.24 mg\u002Fg d. w., respectively. S. cochinchinensis leaf extract exhibited anti-inflammatory effect via in vitro protein denaturation inhibition, hemolysis inhibition by heat and hypotonicity with IC50 values of 63.20, 36.32, and 42.55 μg\u002FmL, respectively. S. cochinchinensis leaf extract also displayed antioxidant potential with IC50 values of 189.09 μg\u002FmL (DPPH inhibition), 60.67 μg\u002FmL (ABTS inhibition), and 140.53 μg\u002FmL (Reducing power). Taken together, S. cochinchinensis leaves have great potential for anti-inflammatory, antioxidant activities and some compounds in pure form should be isolated and studied.\r\nKeywords: S. cochinchinensis leaves, anti-inflammatory activity, antioxidant activity\r\n[1] L. F. Millani, O. H. Nelsen, P. S. Anderson, S. E. Girardin, Chronic Inflammation: Importance of NOD2 and NALP3 in Interleukin-1 beta Generation, Clinical and Experimental Immunology, Vol. 147, No. 2, 2007, pp. 227-235, https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.13652249.2006.03261.x.[2] G. Leelaprakash, S. M. Dass, In Vitro Anti-inflammatory Activity of Methanol Extract of Enicostemma axillare, International Journal of Drug Development & Research, Vol. 3, No. 3, 2011, pp. 189-196.[3] S. Chandra, P. Dey, S. Bhattacharya, Preliminary In Vitro Assessment of Anti-inflammatory Property of Mikania scandens Flower Extract, Journal of Advanced Pharmacy Education & Research, Vol. 2, No. 1, 2012, pp. 25-31.[4] D. B. Kapadiya, B. K. Dabhi, K. D. Aparnathi, Spices and Herbs as a Source of Natural Antioxidants for Food, International Journal of Current Microbiology and Applied Sciences, Vol. 5, No. 7, 2016, pp. 280-288, http:\u002F\u002Fdx.doi.org\u002F10.20546\u002Fijcmas.2016.507.029[5] C. Sunil, S. Ignacimuthu, P. Agastian, Antidiabetic Effect of Symplocos cochinchinensis (Lour.) S. Moore. in Type 2 Diabetic Rats, Journal of Ethnopharmacology, Vol. 134, No. 2, 2011, pp. 298-304, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jep.2010.12.018.[6] C. Sunil, P. Agastian, C. Kumarappan, S. Ignacimuthu, In Vitro Antioxidant, Antidiabetic and Antilipidemic Activities of Symplocos cochinchinensis (Lour.) S. Moore bark, Food and Chemical Toxicology, Vol. 50, No. 5, 2012, pp. 1547-1553, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.fct.2012.01.029.[7] K. A. Antu, M. P. Riya, A. Mishra, K. S. Anilkumar, C. K. Chandrakanth, A. K. Tamrakar, A. K. Srivastava, K. G. Raghu, Antidiabetic Property of Symplocos cochinchinensis is Mediated by Inhibition of Alpha Glucosidase and Enhanced Insulin Sensitivity, PLoS One, Vol. 9, No. 9, 2014, pp. 1-13, https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0105829.[8] B. W. Lee, T. K. Q. Ha, H. T. T. Pham, Q. H. Hoang, V. O. Tran, W. K. Oh, Hydroxyoleoside-type Seco-iridoids from Symplocos cochinchinensis and Their Insulin Mimetic Activity, Scientific Reports, Vol. 9, No. 1, 2019, pp. 1-14, https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41598-018-38013-4.[9] Ministry of Healthy, Vietnamese Pharmacopoeia, Fifth Edition, Medical Publishing House, Hanoi, 2017 (in Vietnamese).[10] P. Chumark, K. Panya, S. Yupin, P. Srichan, M. Noppawan, The In Vitro and Ex Vivo Antioxidant Properties, Hypolipidaemic and Antitherosclerotic Activities of Water Extract of Moringa oleifera Lam. Leave, Journal of Ethnopharmacology, Vol. 116, No. 3, 2008, pp. 439-436, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jep.2007.12.010.[11] T. T. Nguyen, M. O. Parat, M. P. Hodson, J. Pan, P. N. Shaw, A. K. Hewavitharana, Chemical Characterization and In Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica papaya Leaf Extracts, Toxins, Vol. 8, No. 1, 2015, pp. 1-11, https:\u002F\u002Fdoi.org\u002F10.3390\u002Ftoxins8010007.[12] F. Alhakmani, S. Kumar, S. A. Khan, Estimation of Total Phenolic Content, In-vitro Antioxidant and Anti-inflammatory Activity of Flowers of Moringa oleifera, Asian Pacific Journal of Tropical Biomedicine, Vol. 3, No. 8, 2013, pp. 623-627, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs2221-1691(13)60126-4.[13] K. Gunathilake, K. Ranaweera, H. Rupasinghe, In Vitro Anti-inflammatory Properties of Selected Green Leafy Vegetables, Biomedicines, Vol. 6, No. 4, 2018, pp. 1-10, https:\u002F\u002Fdoi.org\u002F10.3390\u002Fbiomedicines6040107.[14] N. Pellegrini, M. Serafini, B. Colombi, D. D. Rio, S. Salvatore, M. Bianchi, F. Brighenti, Total Antioxidant Capacity of Plant Foods, Beverages and Oils Consumed in Italy Assessed by Three Different In Vitro Assays, The Journal of Nutrition, Vol. 133, No. 9, 2003, pp. 2812-2819, https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjn\u002F133.9.2812.[15] M. Oyaizu, Studies on Product of Browning Reaction Prepared from Glucose Amine, The Japanese Journal of Nutrition and Dietetics, Vol. 44, No. 6, 1986, pp. 307-315, https:\u002F\u002Fdoi.org\u002F10.5264\u002Feiyogakuzashi.44.307.[16] S. Dharmadeva, L. S. Galgamuwa, C. Prasadinie, N. Kumarasinghe, In Vitro Anti-inflammatory Activity of Ficus racemosa L. Bark using Albumin Denaturation Method, Ayu, Vol. 39, No. 4, 2018, pp. 239-242, https:\u002F\u002Fdx.doi.org\u002F10.4103%2Fayu.AYU_27_18.[17] E. Umapathy, E. J. Ndebia, A. Meeme, B. Adam, P. Menziwa, B. N. N. Chungag, J. E. Iputo, An Experimental Evaluation of Albuca setosa Aqueous Extract on Membrane Stabilization, Protein Denaturation and White Blood Cell Migration during Acute Inflammation, Journal of Medicinal Plants Research, Vol. 4, No. 9, 2010, pp. 789-795, https:\u002F\u002Fdoi.org\u002F10.5897\u002FJMPR10.056.[18] C. O. Okoli, P. A. Akah, N. J. Onuoha, T. C. Okoye, A. C. Nwoye, C. S. Nworu, Acanthus montanus: An Experimental Evaluation of the Antimicrobial, Anti-inflammatory and Immunological Properties of a Traditional Remedy for Furuncles, BMC Complementary and Alternative Medicine, Vol. 8, 2008, pp. 1-11, https:\u002F\u002Fdoi.org\u002F10.1186\u002F1472-6882-8-27.[19] R. Vadivu, K. S. Lakshmi, In Vitro and In Vivo Anti Inflammatory Activity of Leaves of Symplocos cochinchinensis (Lour) Moore ssp Laurina, Bangladesh Journal of Pharmacology, Vol. 3, No. 2, 2008, pp. 121-124, https:\u002F\u002Fdoi.org\u002F10.3329\u002Fbjp.v3i2.956.[20] T. B. Ng, F. Liu, Z. T. Wang, Antioxidative Activity of Natural Products from Plants, Life Sciences, Vol. 66, No. 8, 2000, pp. 709-723. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0024-3205(99)00642-6.[21] H. Cory, S. Passarelli, J. Szeto, M. Tamez, J. Mattei, The Role of Polyphenols in Human Health and Food Systems: A Mini-review, Frontiers in Nutrition, Vol. 5, 2018, pp. 1-9, https:\u002F\u002Fdx.doi.org\u002F10.3389%2Ffnut.2018.00087.[22] A. N. Panche, A. D. Diwan, S. R. Chandra, Flavonoids: an overview, Journal of Nutritional Science, Vol. 5, 2016, pp. 1-15, https:\u002F\u002Fdx.doi.org\u002F10.1017%2Fjns.2016.41.[23] C. S. Yuan, C. Z. Wang, S. M. Wicks, L. W. Qi, Chemical and Pharmacological Studies of Saponins with a Focus on American Ginseng, Journal of Ginseng Research, Vol. 34, No. 3, 2010, pp. 160-167, https:\u002F\u002Fdx.doi.org\u002F10.5142%2Fjgr.2010.34.3.160.",{"VI":301}," Anti-inflammatory and Antioxidant Activities of Symplocos cochinchinensis (Lour.) Moore ssp. Laurina (Retz.) Nooteb Leaf Extract",{"VOID":303},"16878448978302597441",{"VOID":305},"10.25073\u002F2588-1132\u002Fvnumps.4310","2023-08-03T06:31:29.429+00:00","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4310","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4310\u002F3957",[310,317,324,331,338,345,352,359],{"id":311,"sortIndex":45,"researcher":25,"roles":312,"affiliations":313,"properties":314,"displayName":316,"givenName":25,"familyName":25},"60531a5b-2c21-437e-821b-5bf18531a0b1",[],[],{"title":315},{"VI":316},"Le Van Minh",{"id":318,"sortIndex":45,"researcher":25,"roles":319,"affiliations":320,"properties":321,"displayName":323,"givenName":25,"familyName":25},"9a9177cd-8658-48d4-916e-6576c3af4d03",[],[],{"title":322},{"VI":323},"Le Thi Kim Oanh",{"id":325,"sortIndex":45,"researcher":25,"roles":326,"affiliations":327,"properties":328,"displayName":330,"givenName":25,"familyName":25},"203c2ae6-0e22-443a-a608-4029c5cc083f",[],[],{"title":329},{"VI":330},"Nguyen Thanh Huy",{"id":332,"sortIndex":45,"researcher":25,"roles":333,"affiliations":334,"properties":335,"displayName":337,"givenName":25,"familyName":25},"3847dd45-24c0-4752-a574-f534c101abb8",[],[],{"title":336},{"VI":337},"Pham Cong Sanh",{"id":339,"sortIndex":45,"researcher":25,"roles":340,"affiliations":341,"properties":342,"displayName":344,"givenName":25,"familyName":25},"c216a3f0-f41c-4d52-85e4-76f503c5db84",[],[],{"title":343},{"VI":344},"Ly Hai Trieu",{"id":346,"sortIndex":45,"researcher":25,"roles":347,"affiliations":348,"properties":349,"displayName":351,"givenName":25,"familyName":25},"a3de5486-fa62-43cf-9a2d-653105e34728",[],[],{"title":350},{"VI":351},"Lam Bich Thao",{"id":353,"sortIndex":45,"researcher":25,"roles":354,"affiliations":355,"properties":356,"displayName":358,"givenName":25,"familyName":25},"1acf7714-f48a-4b25-9d55-714e9cef72d2",[],[],{"title":357},{"VI":358},"Tran Ngoc Tuan",{"id":360,"sortIndex":45,"researcher":25,"roles":361,"affiliations":362,"properties":363,"displayName":365,"givenName":25,"familyName":25},"35a0232c-e036-433b-9cb7-ea8d60564c08",[],[],{"title":364},{"VI":365},"Le Thanh Minh",{"url":307,"publisher":367,"properties":393},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":368,"slug":10,"properties":369,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":26,"subjectFields":375,"manageAffiliations":376,"indexDatabases":377,"url":43,"thumbnailPath":25,"statistic":384,"gsStatistic":389,"type":89,"analyzePriority":25},[],{"country":370,"eissn":371,"issn":372,"title":373,"gsId":374},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},{"VOID":21},[],[],[378],{"id":31,"indexDatabase":379,"url":42,"indexYears":25,"academicFieldIds":25,"indexDatabaseRanking":25},{"id":33,"createTime":25,"updateTime":25,"relativeEntities":380,"label":381,"description":382,"key":39,"publicationTags":383,"standard":25},[],{"EN":36,"VI":36},{"EN":38,"VI":38},[41],{"impactFactor":45,"impactFactorByYear":385,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":52,"totalPublicationByYear":386,"totalCitation":62,"totalCitationByYear":387,"totalCitationPerPublication":69,"totalCitationPerPublicationByYear":388,"hindexLast5Year":77,"hindex":77},{"2019":47,"2020":48,"2021":49,"2022":49,"2023":50,"2024":51},{"2016":54,"2017":55,"2018":56,"2019":57,"2020":58,"2021":59,"2022":60,"2023":61,"2024":59},{"2016":64,"2017":64,"2018":65,"2019":54,"2020":66,"2021":65,"2022":67,"2023":68},{"2016":71,"2017":72,"2018":73,"2019":74,"2020":75,"2021":69,"2022":76,"2023":49},{"impactFactor":25,"impactFactorByYear":25,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":79,"totalPublicationByYear":390,"totalCitation":84,"totalCitationByYear":391,"totalCitationPerPublication":87,"totalCitationPerPublicationByYear":392,"hindexLast5Year":81,"hindex":86},{"0":81,"2014":82,"2015":82,"2016":83},{"2016":82,"2019":81,"2021":81,"2023":77,"2024":86,"2025":82,"2026":82},{"2016":47},{"issue":394,"title":396,"volume":399},{"VOID":395},"3",{"EN":397,"VI":398},"Vol. 37 No. 3","Tập 37 Số 3",{"VOID":400},"37","2021-09-21",2021,"2026-05-27T15:23:35.570+00:00",[41],{"id":406,"createTime":407,"updateTime":408,"relativeEntities":409,"slug":410,"properties":411,"entityType":109,"verifyStatus":23,"verifyTime":420,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":82,"primaryUrl":421,"fullTextUrl":422,"authors":423,"publicationType":160,"publisherRelationship":460,"citationCount":25,"citationInfo":25,"publishDate":494,"publishYear":495,"citationAnalyzeStatus":288,"lastCitationAnalyze":496,"indexDatabases":497,"openAccess":25,"references":25,"isForceReanalyzing":201},"74a43a28-901f-4f57-a0d8-e95872f79b55","2023-08-03T05:58:05.594+00:00","2026-08-20T03:37:10.272+00:00",[],"-Clinical-Features-of-Chronic-Sinusitis-in-Adult-Patients-in-the-National-Otorhinolaryngology-Hospital-of-Vietnam-in-2019",{"abstract":412,"title":414,"gsPaper":416,"doi":418},{"EN":413},"Abstract:\r\nThis study describes the clinical features of chronic sinusitis in adult patients in the National Otorhinolaryngology Hospital of Vietnam. The transverse descriptive method was used to describe the clinical features of chronic sinusitis in the adult patients aged 18 and over, suffering from chronic sinusitis in the Inpatient Department, the National Otorhinolaryngology Hospital of Vietnam from August 2019 to December 2019. The average age of the patients was 47.17 ± 15.32, with a male to female ratio of 1.1:1; and the most common reasons for being hospitalized were runny nose (72.4%) and stuffy nose (87.9%). The study concludes that the clinical characteristics of chronic sinusitis in the patients were runny nose, stuffy nose, headache, smell disorder and cough in both men and women, with illness duration ranging from 6 months to many years.\r\nKeywords\r\nChronic sinusitis in adults, stuffy nose, smell disorders.\r\nReferences\r\n[1] W. Fokkens, V. Lund, J. Mullol, European position paper on rhinosinusitis and nasal polyps 2012, Rhinology 2012 (2012), 5-216.[2] B.V. Te, B.T.X. Nga, N.V.M. Nhan, The correlation between sinus endoscopy and CTscan in chronic sinusitis, Proceedings of scientific conference An Giang Hospital, Department of Otolaryngology, October 2013 (2013), pp. 129-137 (in Vietnamese).[3] P.K. Hoa, Chronic rhinitis, Otolaryngology (Used for training general doctors), Vietnam Education Publishing (2012), pp. 61-64 (in Vietnamese).[4] T.T.H. Loan, Chronic sinusitis and current antibiotic resistance, Thesis graduated from general doctor, Hanoi Medical University (2003), p. 53 (in Vietnamese),[5] N.D. Bang, H. K. Cuong, N.V. Cong, Effective prevention of recurrent sinus polyps after laparoscopic surgery with high-dose steroid injections, Thematic eyes – Otolaryngology (2009), pp. 68-75 (in Vietnamese).[6] Đ.T. Lan, Study on clinical, subclinical characteristics and evaluate the results of treatment of chronic sinusitis in adults without nasal polyps according to EPOS 2012, Master's thesis in medicine, Hanoi Medical University (2013). (in Vietnamese).[7] V.V. Khoa, Study on clinical and histopathological characteristics in chronic sinusitis, Doctor of Medicine thesis, Hanoi Medical University (2000). (in Vietnamese).[8] V.T. Quang, Research, diagnose and treat chronic sinusitis through endoscopic sinusoscopy, Doctor of Medicine thesis, Hanoi Medical University (2004). (in Vietnamese).[9] V.T. Quang, Otorhinorarynology textbook, Vietnam National University Press, Hanoi (2012). (in Vietnamese).\r\n ",{"VI":415}," Clinical Features of Chronic Sinusitis in Adult Patients in the National Otorhinolaryngology Hospital of Vietnam in 2019",{"VOID":417},"15079806389123571490",{"VOID":419},"10.25073\u002F2588-1132\u002Fvnumps.4230","2023-08-03T05:58:05.593+00:00","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4230","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4230\u002F3895",[424,431,438,453],{"id":425,"sortIndex":45,"researcher":25,"roles":426,"affiliations":427,"properties":428,"displayName":430,"givenName":25,"familyName":25},"4febb938-4b20-46f9-93cf-0a21be3165ef",[],[],{"title":429},{"VI":430},"Dao Dinh Thi",{"id":432,"sortIndex":45,"researcher":25,"roles":433,"affiliations":434,"properties":435,"displayName":437,"givenName":25,"familyName":25},"de8b8de7-99d6-4f8d-80b0-a567bcd705af",[],[],{"title":436},{"VI":437},"Nguyen Tuan Sơn",{"id":439,"sortIndex":45,"researcher":25,"roles":440,"affiliations":441,"properties":450,"displayName":452,"givenName":25,"familyName":25},"4884033c-6a83-4b3f-a0eb-4e640e1f06de",[],[442],{"id":443,"sortIndex":45,"affiliation":444,"properties":25},"b6343b64-71fa-4ab8-975c-b30d0e4b9e80",{"id":443,"createTime":25,"updateTime":25,"relativeEntities":445,"slug":25,"properties":446,"entityType":25,"verifyStatus":25,"verifyTime":25,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":25,"url":25,"parentIds":449,"statistic":25},[],{"title":447},{"VI":448},"Hà Nội",[],{"title":451},{"VI":452},"Le Hai Nam",{"id":454,"sortIndex":45,"researcher":25,"roles":455,"affiliations":456,"properties":457,"displayName":459,"givenName":25,"familyName":25},"6f774890-88f4-4507-a908-2a99718491de",[],[],{"title":458},{"VI":459},"Vo Thanh Quang",{"url":421,"publisher":461,"properties":487},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":462,"slug":10,"properties":463,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":26,"subjectFields":469,"manageAffiliations":470,"indexDatabases":471,"url":43,"thumbnailPath":25,"statistic":478,"gsStatistic":483,"type":89,"analyzePriority":25},[],{"country":464,"eissn":465,"issn":466,"title":467,"gsId":468},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},{"VOID":21},[],[],[472],{"id":31,"indexDatabase":473,"url":42,"indexYears":25,"academicFieldIds":25,"indexDatabaseRanking":25},{"id":33,"createTime":25,"updateTime":25,"relativeEntities":474,"label":475,"description":476,"key":39,"publicationTags":477,"standard":25},[],{"EN":36,"VI":36},{"EN":38,"VI":38},[41],{"impactFactor":45,"impactFactorByYear":479,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":52,"totalPublicationByYear":480,"totalCitation":62,"totalCitationByYear":481,"totalCitationPerPublication":69,"totalCitationPerPublicationByYear":482,"hindexLast5Year":77,"hindex":77},{"2019":47,"2020":48,"2021":49,"2022":49,"2023":50,"2024":51},{"2016":54,"2017":55,"2018":56,"2019":57,"2020":58,"2021":59,"2022":60,"2023":61,"2024":59},{"2016":64,"2017":64,"2018":65,"2019":54,"2020":66,"2021":65,"2022":67,"2023":68},{"2016":71,"2017":72,"2018":73,"2019":74,"2020":75,"2021":69,"2022":76,"2023":49},{"impactFactor":25,"impactFactorByYear":25,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":79,"totalPublicationByYear":484,"totalCitation":84,"totalCitationByYear":485,"totalCitationPerPublication":87,"totalCitationPerPublicationByYear":486,"hindexLast5Year":81,"hindex":86},{"0":81,"2014":82,"2015":82,"2016":83},{"2016":82,"2019":81,"2021":81,"2023":77,"2024":86,"2025":82,"2026":82},{"2016":47},{"issue":488,"title":489,"volume":492},{"VOID":278},{"EN":490,"VI":491},"Vol. 36 No. 2","Tập 36 Số 2",{"VOID":493},"36","2020-06-25",2020,"2026-05-27T10:40:57.816+00:00",[41],{"id":499,"createTime":500,"updateTime":501,"relativeEntities":502,"slug":503,"properties":504,"entityType":109,"verifyStatus":23,"verifyTime":513,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":45,"primaryUrl":514,"fullTextUrl":515,"authors":516,"publicationType":160,"publisherRelationship":565,"citationCount":25,"citationInfo":25,"publishDate":598,"publishYear":402,"citationAnalyzeStatus":288,"lastCitationAnalyze":599,"indexDatabases":600,"openAccess":25,"references":25,"isForceReanalyzing":201},"abb201e6-3592-42dd-99df-f4c4a3496d9b","2023-08-03T04:26:06.075+00:00","2026-08-20T03:37:10.229+00:00",[],"-Extraction-of-Rice-Bran-Oil-from-Rice-Bran-by-Supercritical-Carbon-Dioxide",{"abstract":505,"title":507,"gsPaper":509,"doi":511},{"EN":506}," \r\nRice bran is an important source of nutrients that have many good bioactive compounds. This study examined the extraction of bran rice oil using supercritical carbon dioxide. Free fatty acids contained in bran rice were stabilized at 5.25% for 8 months by fluid bed dryer equipment. Supercritical carbon dioxide extraction of rice bran oil at pressure of 400 bar, temperature of 60 oC, CO2 flow rate of 20 g\u002Fmin for 120 minutes yielded 14.84% oil. The concentration of γ-oryzanol in rice bran oil extracted by supercritical carbon dioxide (0.50%) was higher than in rice bran oil derived from hexane Soxhlet extraction (0.42%). The effect of pressure and temperature on extraction yield and the concentration of γ-oryzanol contained in rice bran oil was observed.\r\nKeywords\r\nRice bran, rice bran oil, γ-oryzanol, free fatty acid, supercritical carbon dioxide.\r\nReferences\r\n[1] A. A. Wani, P. Singh, M. A. Shah, U. S. Weisz, K. Gul, I. A. Wani, Rice Starch Diversity: Effects on Structural, Morphological, Thermal, and Physicochemical Properties -A Review, Comprehensive Reviews in Food Science and Food Safety, Vol. 11, No. 5, 2012, pp. 417-436, https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1541-4337.2012.00193.x.[2] K. Gul, B. Yousuf, A. K. Singh, P. Singh, A. A. Wani, Rice Bran: Nutritional Values and Its Emerging Potential for Development of Functional Food - A Review, Bioactive Carbohydrates and Dietary Fibre, Vol. 6, No. 1, 2015, pp. 24-30, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bcdf.2015.06.002.[3] G. Hua, S. Huang, S. Cao, Z. Ma, Effect of Enrichment with Hemicellulose from Rice Bran on Chemical and Functional Properties of Bread, Food Chemistry, Vol. 115, No. 3, 2009, pp. 839-842, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.foodchem.2008.12.092.[4] T. S. Shin, J. S. Godber, Changes of Endogenous Antioxidants and Fatty Acid Composition in Irradiated Rice Bran during Storage, Journal of Agricultural Food Chemistry, Vol. 44, 1996, pp. 567-573, https:\u002F\u002Fdoi.org\u002F10.1021\u002Fjf950386a.[5] B. O. Juliano, P. A. Hicks, Rice Functional Properties and Rice Food Products, Food Reviews International, Vol. 12, No. 1, 1996, pp. 71-103, https:\u002F\u002Fdoi.org\u002F10.1080\u002F87559129609541068.[6] M. Ghosh, Review on Recent Trends in Rice Bran Oil Processing, J Amer Oil Chem Soc,Vol. 84, 2007, pp. 315-324, https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11746-007-1047-3.[7] M. Sugano, E. Tsuji, Rice Bran Oil and Cholesterol Metabolism, Journal of Nutrition, Vol. 127, No. 3, 1997, pp. 521-524, https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjn\u002F127.3.521S.[8] G. S. Seetharamaiah, N. Chandrasekhara, Studies on Hypocholesterolemic Activity of Rice Bran Oil, Atherosclerosis, Vol. 78, No. 2-3, 1989, pp. 219-223, https:\u002F\u002Fdoi.org\u002F10.1016\u002F0021-9150(89)90226-8.[9] J. K. Duve, P. J. White, Extraction and Identification of Antioxidants in Oats, Journal of American Oil Chemists Society, Vol. 68, No. 6, 1991, pp. 365-37, https:\u002F\u002Fdoi.org\u002F10.1007\u002FBF02663751.[10] L. Xu, X. Zhan, Z. Zeng, R. Chen, H. Li, T. Xie, S. Wang, Recent Advances on Supercritical Fluid Extraction of Essential Oils, African Journal of Pharmacy and Pharmacology, Vol. 5, No. 9, 2011, pp. 1196-1211, https:\u002F\u002Fdoi.org\u002F10.5897\u002FAJPP11.228.[11] C. R. Chen, C. H. Wang, L. Y. Wang, Z. H. Hong, S. H. Chen, W. J. Ho, C. M. J. Chang, Supercritical Carbon Dioxide Extraction and Deacidification of Rice Bran Oil, J. of Supercritical Fluids, Vol. 45, No. 3, 2008, pp. 322-331, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.supflu.2008.01.006.[12] K. Tomita, S. Machmudah, Wahyudiono, R. Fukuzato, H. Kanda, A. T. Quitain, M. Sasaki, M. Goto, Extraction of Rice Bran Oil by Supercritical Carbon Dioxide and Solubility Consideration, Separation and Purification Technology, Vol. 125, No. 7, 2014, pp. 319-325, http:\u002F\u002Fdx.doi.org\u002F10.1016\u002Fj.seppur.2014.02.008.[13] F. Malekian, R. M. Rao, W. Prinyawiwatkul, W. E. Marshall, M. Windhauser, M. Ahmedna, Lipase and Lipoxygenase Activity, Functionality, and Nutrient Losses in Rice Bran During Storage, Bull. La. Agric. Exp. Stn. LSU Agric. Cent., Vol. 870, 2000, pp. 1-68.[14] S. Akter, M. Ahiduzzaman, Effect of Storage Life of Rice Bran on the Quality of Oil, Journal of Food and Nutrition Sciences, Vol. 5, No. 1, 2017, pp. 11-15, https:\u002F\u002Fdoi.org\u002F10.11648\u002Fj.jfns.20170501.12.[15] H. R. Sharma, G. S. Chauhan, K. Agrawal, Physico-Chemical Characteristics of Rice Bran Processed by Dry Heating and Extrusion Cooking, International Journal of Food Properties, Vol. 7, No. 3, 2004, pp. 603-614, https:\u002F\u002Fdoi.org\u002F10.1081\u002FJFP-200033047.[16] N. R. Lakkakula, M. Lima, T. Walker, Rice Bran Stabilization and Rice Bran Oil Extraction using Ohmic Heating, Bioresource Technology, Vol. 92, No. 2, 2004, pp. 157-161, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biortech.2003.08.010.[17] D. Martin, J. S. Gober, G. Selhako, L. Verma, J. H. Wells, Optimizing Rice Bran Stabilization by Extrusion Cooking, Lousiana Agraculture, Vol. 30, 1993, pp. 13.[18] R. N. Sayre, R. M. Saunders, R. V. Enochian, W. G. Shultz, E. C. Beagle, Review of Rice Bran Stabilization Systems with Emphasis on Extrusion Cooking, Cereal Food World, Vol. 7, 1982, pp. 317.[19] M. S. Kuk, M. K. Dowd, Supercritical CO2 Extraction of Rice Bran, J. Am. Oil Chem. Soc, Vol. 75, 1998, pp. 623-628.[20] Y. T. Chen, Y. H. Ling, An Overview of Supercritical Fluid Extraction in Chinese Herbal Medicine: from Preparation to Analysis, J. Food Drug Anal, Vol. 8, No. 4, 2000, pp. 235-247, https:\u002F\u002Fdoi.org\u002F10.38212\u002F2224-6614.2815.[21] S. R. S. Ferreira, Z. L. Nikolov, L. K. Doraiswamy, M. A. A. Meireles, A. J. Petenatee, Supercritical Fluid Extraction of Black Pepper (Piper nigrun L.) Essential Oil, J. Supercrit. Fluids, Vol. 14, No. 3, 1999, pp. 235-245.[22] A. Awasthi, R. K. Trivedi, A Review of Supercritical Carbon Dioxide Extraction of Natural Products, Chem. Eng. World, Vol. 32, 1997, pp. 65-71.\r\n \r\n \r\n ",{"VI":508}," Extraction of Rice Bran Oil  from Rice Bran by Supercritical Carbon Dioxide",{"VOID":510},"3818228892012055527",{"VOID":512},"10.25073\u002F2588-1132\u002Fvnumps.4286","2023-08-03T04:26:06.074+00:00","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4286","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4286\u002F3939",[517,524,533,540,557],{"id":518,"sortIndex":45,"researcher":25,"roles":519,"affiliations":520,"properties":521,"displayName":523,"givenName":25,"familyName":25},"145b1634-7af0-4228-9f87-dab83637fbc1",[],[],{"title":522},{"VI":523},"Tran Quoc Thinh",{"id":525,"sortIndex":45,"researcher":25,"roles":526,"affiliations":527,"properties":528,"displayName":530,"givenName":25,"familyName":25},"b441db75-d0c0-4864-9276-855851a3a92d",[],[],{"title":529,"gsAuthor":531},{"VI":530},"Nguyen Thanh 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MT-ATP6 gene encodes for a protein subunit which is central to the proton channel of the ATP synthase. Mutations of MT-ATP6 gene can affect the ATP synthesis and may play an important role in the process of tumorigenesis. The purpose of this study was to identify potential changes of MT-ATP6 gene in pair of tumor and adjacent tissues of 102 patients with breast cancer and in blood samples of 65 controls by using direct DNA sequencing and PCR-RFLP method. Then, statistical analysis was used to analyze the association between some typical changes and pathological features of breast cancer. As a result, 20 changes in the MT-ATP6 gene in 35 examined breast cancer tissues and 13 changes in 26 blood control samples were reported, of which 12 alterations altered the amino acid and a variant, 9183insC, had not been described in the literature so far. Most of the variants had low frequencies from 2.86% to 5.71%. Two variants, G9053A and G8584A, which changed the amino acid sequence and had high frequency, were screened in all samples. Our results indicated that the frequencies of G9053A and G8584A were 21,6% (22\u002F102 cases) and 24,5% (25\u002F102 cases) respectively in tissues of breast cancer patients and 18,5% (12\u002F65 cases) in normal blood controls. However, there was no statistically significant difference in G9053A and G8485A rates between breast cancer patients and controls as well as between mtDNA alterations and the pathological features of breast cancer such as age, size of tumors, number of lymph nodes, size of lymph nodes, T stage, N stage, tumor differentiation and stages of disease. This study showed that the variations of MT-ATP6 gene differed from patient groups. In Vietnamese patients with breast cancer, the rates of G9053A and G8485A were relatively high but these changes were not statistically related to breast cancer.","Gen MT-ATP6 ty thể mã hóa cho tiểu đơn vị protein a, trung tâm của kênh proton của phức hệ tổng hợp ATP. Biến đổi của gen MT-ATP6 được cho là ảnh hưởng đến quá trình tổng hợp ATP và có liên quan với quá trình tạo u. Trong nghiên cứu này, biến đổi của gen  MT-ATP6 được xác định trên 102 mẫu mô của bệnh nhân ung thư vú và 65 mẫu máu đối chứng sử dụng phương pháp PCR giải trình tự trực tiếp và PCR-RFLP, sau đó sử dụng các phương pháp phân tích thống kê để đánh giá mối liên quan giữa một số biến đổi điển hình với các đặc điểm bệnh học của ung thư vú. Kết quả đã xác định được 20 biến đổi của gen MT-ATP6 trên 35 mẫu mô u của bệnh nhân ung thư vú và 13 biến đổi trên 26 mẫu máu của người bình thường, trong đó có 12 biến đổi làm thay đổi trình tự axít amin và 1 biến đổi 9183insC chưa được công bố trước đây. Đa số các biến đổi có tần suất thấp từ 2,86% đến 5,71%. Các biến đổi làm thay đổi trình tự axít amin G9053A và G8584A với tần suất cao trên mẫu mô u được sàng lọc trong các mẫu nghiên cứu. Kết quả cho thấy tỉ lệ dạng biến đổi G9053A và G8584A tương ứng là 21,6% (22\u002F102 trường hợp) và 24,5% (25\u002F102 trường hợp) ở mô của bệnh nhân ung thư vú và 18,5% (12\u002F65 trường hợp) ở mẫu máu của người bình thường. Tuy nhiên, không có sự khác biệt có ý nghĩa thống kê về tỉ lệ biến đổi G9053A và G8485A khi so sánh giữa nhóm bệnh nhân và đối chứng cũng như theo các đặc điểm bệnh học của ung thư vú như độ tuổi, kích thước khối u, số hạch, kích thước hạch, mức độ xâm lấn (giai đoạn T), mức độ hạch (giai đoạn N), mức độ biệt hóa của khối u và giai đoạn bệnh. Nghiên cứu này cho thấy biến đổi của gen MT-ATP6 khác nhau tùy thuộc vào từng nhóm bệnh nhân. Trên đối tượng bệnh nhân ung thư vú Việt Nam, tỉ lệ biến đổi G9053A và G8485A tương đối cao, tuy nhiên các biến đổi này không có mối liên hệ có ý nghĩa thống kê với bệnh ung thư vú.",{"VI":681}," Preliminary Study of MT-ATP6 Gene’s Alterations  in Patients with Breast Cancer in Vietnam",{"VOID":683},"8297752645192855687",{"VOID":685},"10.25073\u002F2588-1132\u002Fvnumps.4087","2023-08-03T07:06:26.313+00:00",5,"https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4087","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4087\u002F3807",[691,698,707,714],{"id":692,"sortIndex":45,"researcher":25,"roles":693,"affiliations":694,"properties":695,"displayName":697,"givenName":25,"familyName":25},"6036818d-53a1-4f83-817f-3eca9e847fe9",[],[],{"title":696},{"VI":697},"Do Thi 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33 No. 2","Tập 33 Số 2",{"VOID":768},"33","2017-12-01",2017,"2026-05-27T12:20:35.926+00:00",[41],{"id":774,"createTime":775,"updateTime":776,"relativeEntities":777,"slug":778,"properties":779,"entityType":109,"verifyStatus":23,"verifyTime":788,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":45,"primaryUrl":789,"fullTextUrl":790,"authors":791,"publicationType":160,"publisherRelationship":809,"citationCount":82,"citationInfo":842,"publishDate":844,"publishYear":495,"citationAnalyzeStatus":198,"lastCitationAnalyze":845,"indexDatabases":846,"openAccess":25,"references":25,"isForceReanalyzing":201},"ae13e415-35db-4e6d-9a74-66ce67d3862f","2023-08-03T04:16:50.651+00:00","2026-08-20T03:37:10.149+00:00",[],"-Henoch-Schonlein-Purpura-in-Children-at-Department-of-Pediatric-Bach-Mai-Hospital",{"abstract":780,"title":782,"gsPaper":784,"doi":786},{"EN":781},"Objectives: To identify the percentage of parents having the correct knowledge of caring their children and evaluable quality of life in children with chronic kidney diseases. Subject and method: descriptive cross sectional study and  evaluated the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales of 115 children with chronic kidney diseases (CKD) and their parents who treated at Department of Pediatric of Bach Mai hospital. Results: the parents’ correct knowledge about CKD was persistant and relapse (90,4% and 89,4%). The sourse of information parents’s from medical staffs was 48,2% and 23% from social networking. Over 50% of parents thought that knowledge getting from medical staffs was necessary. Beside that 33% of parents thought that information gettinh from social networking was harmful. Total quality of life score of children with CKD was 21,9 ± 14,9  point. Physical and learning field were more effective. However, total quality of life score of children with CKD whose parents got consulting of medical staffs was lower than wothout medical staffs’s consulting. The difference between total quality of life score of children with CKD and job of parents was not is not statistically significant. Conclusion: the supply more information will help parents understand their role in co-operation with medical staffs to help the children integrate into the normal society and enhance their quality of life.\r\nKeywords\r\nKnowledge,chronic kidney diseases.\r\nReferences\r\n[1] EULAR\u002FPRINTO\u002FPRES, Citeria for Henoch– Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008, Part II: Final classification criteria, AnnRheum Dis 69 (2010) 798–806.[2] Seza Ozen, Stephen D. Marks, Paul Brogan et al, European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative, Rheumatology, 58(9) (2019) 1607–1616.[3] L.J. Liu,J. Yu and Y.N. Li, Clinical characteristics of Henoch-Schonlein purpura in children, Zhongguo dang dai er ke za zhi. Chinese journal of contemporary pediatrics 17(10) (2015) 1079-1083.[4] Le Thi Minh Huong, Thuc Thanh Huyen, study about characteristics of clinical and paraclinical manifestations of HSP in children in National Pedicatrics of hospital, Journal of Practical Medicine 874(6) (2013) 91-94 (in Vietnamese).[5] Y.H. Lee, Y.B. Kim, J.W. Koo et al, Henoch-Schonlein Purpura in children hospitalized at a tertiary hospital during 2004-2015 in Korea: epidemiology and clinical management,Pediatric gastroenterology, hepatology & nutrition 19(3) (2016) 175-185.[6] I.M. Buscatti, B.B. Casella, N.E. Aikawa et al, Henoch-Schönlein purpura nephritis: initial risk factors and outcomes in a Latin American tertiary center. Clin Rheumatol 37(5) (2018) 1319-1324.[7] J.D. Delbet, J. Hogan, B. Aoun et al, Clinical outcomes in children with Henoch-Schönlein purpura nephritis without crescents. Pediatr Nephrol 32(7) (2017) 1193-1199. \r\n \r\n \r\n \r\n ",{"EN":783}," Henoch-Schonlein Purpura in Children at  Department of Pediatric, Bach Mai Hospital",{"VOID":785},"1458868070979879464",{"VOID":787},"10.25073\u002F2588-1132\u002Fvnumps.4199","2023-08-03T04:16:50.650+00:00","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4199","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4199\u002F3889",[792],{"id":793,"sortIndex":45,"researcher":25,"roles":794,"affiliations":795,"properties":806,"displayName":808,"givenName":25,"familyName":25},"111e753f-6b5c-4a8c-8d84-2e1e1bc567d0",[],[796],{"id":226,"sortIndex":45,"affiliation":797,"properties":803},{"id":226,"createTime":25,"updateTime":25,"relativeEntities":798,"slug":25,"properties":799,"entityType":25,"verifyStatus":25,"verifyTime":25,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":25,"url":25,"parentIds":802,"statistic":25},[],{"title":800,"country":801},{"EN":231,"VI":232},{"VOID":13},[235],{"title":804},{"VI":805},"Khoa Y Dược, ĐHQGHN",{"title":807},{"VI":808},"Pham Van Dem",{"url":789,"publisher":810,"properties":836},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":811,"slug":10,"properties":812,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":26,"subjectFields":818,"manageAffiliations":819,"indexDatabases":820,"url":43,"thumbnailPath":25,"statistic":827,"gsStatistic":832,"type":89,"analyzePriority":25},[],{"country":813,"eissn":814,"issn":815,"title":816,"gsId":817},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},{"VOID":21},[],[],[821],{"id":31,"indexDatabase":822,"url":42,"indexYears":25,"academicFieldIds":25,"indexDatabaseRanking":25},{"id":33,"createTime":25,"updateTime":25,"relativeEntities":823,"label":824,"description":825,"key":39,"publicationTags":826,"standard":25},[],{"EN":36,"VI":36},{"EN":38,"VI":38},[41],{"impactFactor":45,"impactFactorByYear":828,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":52,"totalPublicationByYear":829,"totalCitation":62,"totalCitationByYear":830,"totalCitationPerPublication":69,"totalCitationPerPublicationByYear":831,"hindexLast5Year":77,"hindex":77},{"2019":47,"2020":48,"2021":49,"2022":49,"2023":50,"2024":51},{"2016":54,"2017":55,"2018":56,"2019":57,"2020":58,"2021":59,"2022":60,"2023":61,"2024":59},{"2016":64,"2017":64,"2018":65,"2019":54,"2020":66,"2021":65,"2022":67,"2023":68},{"2016":71,"2017":72,"2018":73,"2019":74,"2020":75,"2021":69,"2022":76,"2023":49},{"impactFactor":25,"impactFactorByYear":25,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":79,"totalPublicationByYear":833,"totalCitation":84,"totalCitationByYear":834,"totalCitationPerPublication":87,"totalCitationPerPublicationByYear":835,"hindexLast5Year":81,"hindex":86},{"0":81,"2014":82,"2015":82,"2016":83},{"2016":82,"2019":81,"2021":81,"2023":77,"2024":86,"2025":82,"2026":82},{"2016":47},{"issue":837,"title":838,"volume":841},{"VOID":190},{"EN":839,"VI":840},"Vol. 36 No. 1","Tập 36 Số 1",{"VOID":493},{"total":82,"publishYear":495,"statisticByYear":843},{"2024":82},"2020-03-24","2025-08-04T05:42:23.791+00:00",[41],{"id":848,"createTime":849,"updateTime":850,"relativeEntities":851,"slug":852,"properties":853,"entityType":109,"verifyStatus":23,"verifyTime":862,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":82,"primaryUrl":863,"fullTextUrl":864,"authors":865,"publicationType":160,"publisherRelationship":897,"citationCount":25,"citationInfo":25,"publishDate":930,"publishYear":285,"citationAnalyzeStatus":931,"lastCitationAnalyze":25,"indexDatabases":932,"openAccess":25,"references":25,"isForceReanalyzing":201},"31d2439e-dd23-41e1-896f-3b0532926426","2023-08-03T05:14:53.842+00:00","2026-08-20T03:37:10.117+00:00",[],"-Characteristics-of-EGFR-Mutations-in-Plasma-Samples-in-Non-Small-Cell-Lung-Cancer-Patients-after-Treatment-with-1st-and-2nd-Generation-of-TKI-at-Bach-Mai-Hospital",{"abstract":854,"title":856,"gsPaper":858,"doi":860},{"EN":855},"This study aims to describe EGFR mutation status detected in plasma samples and analyze some related factors in non-small cell lung cancer patients after treatment with the generation I and II Tyrosine Kinase inhibitors at Bach Mai Hospital. Patients and methods: A retrospective descriptive study on 75 patients with non-small cell lung cancer tested for EGFR mutations in plasma after treatment with 1st or 2nd EGFR-TKIs in 2019-2020. Results: EGFR mutations were detected in 97.3% plasma samples;  the T790M mutation accounted for  37.3% and is accompanied by a sensitive mutation TKI; The T790M mutations ratio after treatment was higher than before treatment with TKIs (p < 0.001); the median total duration of EGFR-TKI treatment was significantly longer in patients with T790M mutation than in those without (16.8 months vs 12.5 months, p = 0.005); the T790M mutation ratio was higher in patients with a deletion on exon 19 than in L858R mutation on exon 21 (p=0.028), in Erlotinib treatment group higher than in Gefitinib and Afatinib treatment group (51.4% vs. with 20.0% and 33.3%, p=0.039). Conclusions: EGFR mutation plasma test helps to monitor disease progression and detect resistance mutations T790M in NSCLC patients after TKI generation I and II.\r\nKeywords: non-small cell lung cancer, EGFR mutations, T790M mutations, TKIs..\r\nReferences\r\n[1] H. Sung et al., Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers In 185 Countries, CA: A Cancer Journal for Clinicians. Vol. 71, No. 3, 2021, pp. 209-249, https:\u002F\u002Fdoi.org\u002F10.3322\u002Fcaac.21660.[2] N. V. Hieu, Oncology, Medical Publisher, 2015.[3] P. N. Ding et al., Plasma Pre-treatment T790M Relative Allelic Frequency in Patients with Advanced EGFR-mutated Non-small Cell Lung Cancer Predicts Treatment Response to Subsequent-Line Osimertinib, Translational Lung Cancer Research, Vol. 10, No. 4, 2021, pp. 1623-1634, https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs40169-020-0269-y.[4] N. Yamamoto et al., Erlotinib Plus Bevacizumab Vs Erlotinib Monotherapy as First-line Treatment for Advanced EGFR Mutation-positive Non-squamous Non-small-cell Lung Cancer: Survival Follow-up Results of the Randomized JO25567 Study, Lung Cancer, Vol. 151, 2021, pp.20-24, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.lungcan.2020.11.020.[5] D. S. Ettinger et al., NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 2, 2021: Featured Updates to the NCCN Guidelines\", Journal of the National Comprehensive Cancer Network, Vol. 19, No. 3, 2021, pp. 254-266, https:\u002F\u002Fdoi.org\u002F10.6004\u002Fjnccn.2021.0013.[6] K. Usui et al., Plasma ctDNA Monitoring During Epidermal Growth Factor Receptor (EGFR)-Tyrosine Kinase Inhibitor Treatment in Patients With EGFR-mutant Non-small Cell Lung Cancer (JP-CLEAR trial), Japanese Journal of Clinical Oncology, Vol. 49, No. 6, 2021, pp. 554-558, https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjjco\u002Fhyz023.[7] M. Nagasaka et al., Liquid Biopsy for Therapy Monitoring in Early-stage Non-small Cell Lung Cancer, Molecular Cancer, Vol. 20, No. 1, 2021, pp. 82, https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12943-021-01371-1.[8] M. D. Re et al., Incidence of T790M in Patients with NSCLC Progressed to Gefitinib, Erlotinib, and Afatinib: A Study on Circulating Cell-free DNA, Clinical Lung Cancer, Vol. 21, No. 3, 2020, pp. 232-237, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cllc.2019.10.003.[9] S. Jenkins et al., Plasma ctDNA Analysis for Detection of the EGFR T790M Mutation in Patients with Advanced Non–small Cell Lung Cancer\", Journal of Thoracic Oncology, Vol. 12, No. 7, 2017, pp. 1061-1070, https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jtho.2017.04.003.[10] R. Ko et al., Frequency of EGFR T790M Mutation and Multimutational Profiles of Rebiopsy Samples from Non-small Cell Lung Cancer Developing Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Japanese Patients, BMC Cancer, Vol. 16, No. 1, 2016, pp. 864, https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12885-016-2902-0.[11] N. Matsuo et al., Association of EGFR Exon 19 Deletion and EGFR-TKI Treatment Duration with Frequency of T790M Mutation in EGFR-Mutant Lung Cancer Patients, Scientific Reports, Vol. 6, No. 1, 2016, pp. 36458 , https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsrep36458.[12] W. Fanget al., EGFR Exon 20 Insertion Mutations and Response to Osimertinib in Non-small-cell Lung Cancer, BMC Cancer, Vol. 19, No. 1, 2019, pp. 1-9, https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12885-019-5820-0.[13] D. T. Hien, P. C. Phuong, Analysis of EGFR Mutations in Paraffin-covered Tissue Samples and some Related Factors from Non-small Cell Lung Cancer Patients Over 60 Years Old, Science and Technology Vietnam, Vol. 62, No. 7, 2020, pp. 1-5[14] S. Hong et al., Concomitant Genetic Alterations with Response to Treatment and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Advanced Non–small Cell Lung Cancer, JAMA Oncology, Vol. 4, No. 5, 2018, pp. 739-742, https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjamaoncol.2018.0049.",{"VI":857}," Characteristics of EGFR Mutations in Plasma Samples  in Non-Small Cell Lung Cancer Patients after Treatment  with 1st and 2nd Generation of TKI at Bach Mai Hospital",{"VOID":859},"16593238768818098010",{"VOID":861},"10.25073\u002F2588-1132\u002Fvnumps.4368","2023-08-03T05:14:53.841+00:00","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fview\u002F4368","https:\u002F\u002Fjs.vnu.edu.vn\u002FMPS\u002Farticle\u002Fdownload\u002F4368\u002F3983",[866,883,890],{"id":867,"sortIndex":45,"researcher":25,"roles":868,"affiliations":869,"properties":878,"displayName":880,"givenName":25,"familyName":25},"24ca5b09-259e-4cfd-996e-cfe802c8c54d",[],[870],{"id":871,"sortIndex":45,"affiliation":872,"properties":25},"cd9c1bbf-a14f-4f82-b10f-1e82ec90eebc",{"id":871,"createTime":25,"updateTime":25,"relativeEntities":873,"slug":25,"properties":874,"entityType":25,"verifyStatus":25,"verifyTime":25,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":25,"url":25,"parentIds":877,"statistic":25},[],{"title":875},{"VI":876},"Đại học y Dược",[],{"title":879,"gsAuthor":881},{"VI":880},"Nguyen Thuan Loi",{"VOID":882},"E8x-hq4AAAAJ",{"id":884,"sortIndex":45,"researcher":25,"roles":885,"affiliations":886,"properties":887,"displayName":889,"givenName":25,"familyName":25},"b8148855-3b93-45a2-8b82-a077eed92bb3",[],[],{"title":888},{"VI":889},"Pham Cam Phuong",{"id":891,"sortIndex":45,"researcher":25,"roles":892,"affiliations":893,"properties":894,"displayName":896,"givenName":25,"familyName":25},"2ddfec85-302f-4e24-a986-fc0e977e7534",[],[],{"title":895},{"VI":896},"Do Dinh Hung",{"url":863,"publisher":898,"properties":924},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":899,"slug":10,"properties":900,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":25,"languages":25,"translateLanguages":25,"viewCount":26,"subjectFields":906,"manageAffiliations":907,"indexDatabases":908,"url":43,"thumbnailPath":25,"statistic":915,"gsStatistic":920,"type":89,"analyzePriority":25},[],{"country":901,"eissn":902,"issn":903,"title":904,"gsId":905},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},{"VOID":21},[],[],[909],{"id":31,"indexDatabase":910,"url":42,"indexYears":25,"academicFieldIds":25,"indexDatabaseRanking":25},{"id":33,"createTime":25,"updateTime":25,"relativeEntities":911,"label":912,"description":913,"key":39,"publicationTags":914,"standard":25},[],{"EN":36,"VI":36},{"EN":38,"VI":38},[41],{"impactFactor":45,"impactFactorByYear":916,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":52,"totalPublicationByYear":917,"totalCitation":62,"totalCitationByYear":918,"totalCitationPerPublication":69,"totalCitationPerPublicationByYear":919,"hindexLast5Year":77,"hindex":77},{"2019":47,"2020":48,"2021":49,"2022":49,"2023":50,"2024":51},{"2016":54,"2017":55,"2018":56,"2019":57,"2020":58,"2021":59,"2022":60,"2023":61,"2024":59},{"2016":64,"2017":64,"2018":65,"2019":54,"2020":66,"2021":65,"2022":67,"2023":68},{"2016":71,"2017":72,"2018":73,"2019":74,"2020":75,"2021":69,"2022":76,"2023":49},{"impactFactor":25,"impactFactorByYear":25,"i10Index":45,"i10IndexLast5Year":45,"totalPublication":79,"totalPublicationByYear":921,"totalCitation":84,"totalCitationByYear":922,"totalCitationPerPublication":87,"totalCitationPerPublicationByYear":923,"hindexLast5Year":81,"hindex":86},{"0":81,"2014":82,"2015":82,"2016":83},{"2016":82,"2019":81,"2021":81,"2023":77,"2024":86,"2025":82,"2026":82},{"2016":47},{"issue":925,"title":926,"volume":929},{"VOID":190},{"EN":927,"VI":928},"Vol. 38 No. 1","Tập 38 Số 1",{"VOID":283},"2022-03-24","ANALYZING_CITATION",[41],{"id":934,"createTime":935,"updateTime":936,"relativeEntities":937,"slug":938,"properties":939,"entityType":109,"verifyStatus":23,"verifyTime":948,"verifyNote":111,"languages":25,"translateLanguages":25,"viewCount":45,"primaryUrl":949,"fullTextUrl":950,"authors":951,"publicationType":160,"publisherRelationship":1000,"citationCount":81,"citationInfo":1031,"publishDate":844,"publishYear":495,"citationAnalyzeStatus":288,"lastCitationAnalyze":1033,"indexDatabases":1034,"openAccess":25,"references":25,"isForceReanalyzing":201},"d824b33e-5c30-422c-a4be-5ac28e013fe5","2023-08-03T06:17:18.772+00:00","2026-08-20T03:37:10.076+00:00",[],"-Comparing-Acetylcholinesterase-and-Butyrylcholinesterase-Inhibition-Effect-of-Total-Extract-and-Fractions-with-Alcaloid-Rich-Extract-of-Huperzia-Serrata-Thunb-Trevis-",{"abstract":940,"title":942,"gsPaper":944,"doi":946},{"EN":941},"Herbal extract, rich with natural compounds, has been used for medicinal purpose such as treating neurological disorders such as cognitive defection for a long period of time, often without significant adverse effects. We compared AChE and BuChE – inhibition effect of total extracts and fractions of Huperzia serrata (Thunb.) Trevis. with alcaloid-rich extract. Our samples were subjected under supersonic extraction with ethanol 50o as solvent and fractionally extracted with n-hexane, EtOAc and n-butanol, respectively; alcaloid-rich extract was collected simutaneously. Ellman’s method was used to assay AChE and BuChE inhibition activity. Results: Alcaloid-rich extraction proved to be the superior AChE inhibiting agent, its activity nearly 6 fold of the most active Huperzia serrata extraction with IC50 value of 7.93 (5.43-10.98) µg\u002Fml. While the fractions as well as the total extract did not provide any BuChE inhibition activity, alcaloid-rich extract showed weak ability (IC50 at 76.67 (64.78 – 91.84) µg\u002Fml). Overall, the superior enzyme inhibition effect of alcaloid-rich extract might open a new approach in preventing and treating neurological disorders such as alzheimer’s.\r\nKeywords\r\nHuperzia serrata (Thunb.) Trevis, alcaloid, Acetylcholinesrerase inhibitors (AChE); butyrylcholinesterase (BuChE), Alzheimer.\r\nReferences\r\n[1] Dos Santos Picanco, Leide C et al., Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment, Current medicinal chemistry 25(26) (2018) 3141 - 3159. https:\u002F\u002Fdoi.org\u002F10.2174\u002F0929867323666161213101126.[2] B.M. McGleenon, K.B. Dynan, A.P. Passmore, Acetylcholinesterase inhibitors in Alzheimer's disease, British journal of clinical pharmacology 48(4) (1999) 471-480. https:\u002F\u002F10.1046\u002Fj.1365-2125.1999.00026.x.[3] Agneta Nordberg, Clive Ballard, Roger Bullock, Taher Darreh-Shori, Monique Somogyi, A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer’s disease, The primary care companion for CNS disorders 15(2) (2013). https:\u002F\u002F10.4088\u002FPCC.12r01412.[4] N.M. Ha, V.V. Dung et al., Report on the review of Vietnam’s wildlife trade policy, 2007.[5] D.H. Bich, et al., Medicinal plants and medicinal animals in Viet Nam. Science and Technics Publishing House 1 (2011) 896-897 (in Vietnamese).[6] Jia-Sen Liu, Yuan-Long Zhu, Chao-Mei Yu, You-Zuo Zhou, Yan-Yi Han, Feng-Wu Wu, Bao-Feng Qi, The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity. Canadian Journal of Chemistry 64(4) (1986) 837-839. https:\u002F\u002Fdoi.org\u002F10.1139\u002Fv86-137.[7] Takuya Ohba, Yuta Yoshino et al., Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice, Bioscience biotechnology and biochemistry 79(11) (2015) 1838-1844. https:\u002F\u002Fdoi.org\u002F10.1080\u002F09168451.2015.1052773.[8] Ju-Yeon Park, Hyuck Kim et al., Ethanol Extract of Lycopodium serratum Thunb. Attenuates Lipopolysaccharide-Induced C6 Glioma Cells Migration via Matrix Metalloproteinase-9 Expression, Chinese Journal of Integrative Medicine 24(11) (2018) 860-866. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11655-017-2923-9.[9] M. Maridass, G. Raju, Investigation of phytochemical and antimicrobial activity of Huperzia species, Pharmacologyonline 3 (2009) 688-692.[10] George.L.Ellman, K.Diane Courtney, et al., A new and rapid colorimetric determination of acetylcholinesterase activity, Biochemical Pharmacology 7(2) (1961) 88-95. https:\u002F\u002Fdoi.org\u002F10.1016\u002F0006-2952(61)90145-9.[11] Paul T Francis, et al., The cholinergic hypothesis of Alzheimer’s disease: a review of progress. Journal of Neurology, Neurosurgery & Psychiatry, 66(2) (1999) 137-147. http:\u002F\u002Fdx.doi.org\u002F10.1136\u002Fjnnp.66.2.137.[12] Prerna Upadhyaya, Vikas Seth, Mushtaq Ahmad, Therapy of Alzheimer’s disease: An update, African Journal of Pharmacy and Pharmacology 4(6) (2010) 408-421.[13] Hachiro Sugimoto, Hiroo Ogura, et al., Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor, The Japanese journal of pharmacology 89(1) (2002) 7-20.[14] N.T.K. Thu, et al., Acetylcholinesterase and butyrylcholinesterase inhibition effect of fractions extract of Huperzia serrata (Thunb.) Trevis. The journal of Pharmeceutical 56(11) 49-53 (in Vietnamese).[15] Xiaoqiang Ma, Changheng Tan, et al, Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China. J Agric Food Chem, 53(5) (2005)1393-8. https:\u002F\u002Fdoi.org\u002F10.1021\u002Fjf048193n.[16] Ya-Bing Yang, Xue-Qiong Yang, et al., A New Flavone Glycoside from Huperzia serrata. Chinese Journal of Natural Medicines 6(6) (2008) 408-410.[17] G.T. Ha, R.K. Wong, Y. Zhang, Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies, Chemistry & biodiversity 8(7) (2011) 1189-1204. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fcbdv.201000269.[18] H.Y. Zhang, X.C. Tang, Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease, Trends in pharmacological sciences 27(12) (2006) 619-625. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.tips.2006.10.004.[19] Y. Wang, X.C. Tang, H.Y. Zhang, Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe\u002FPS1dE9 transgenic mice, Journal of neuroscience research 90(2) (2012) 508-517. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjnr.22775.[20] C.Y. Wang, et al., Huperzine A activates Wnt\u002Fβ-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model, Neuropsychopharmacology 36(5) (2011) 1073-1089. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnpp.2010.245.[21] R.K. Gordon, et al., The NMDA receptor ion channel: a site for binding of Huperzine A, Journal of applied toxicology 21(S1) (2001) S47-S51. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjat.805.[22] M. Rafii, et al., A phase II trial of huperzine A in mild to moderate Alzheimer disease, Neurology 76(16) (2011) 1389-1394. https:\u002F\u002Fdoi.org\u002F10.1212\u002FWNL.0b013e318216eb7b.[23] N.H. Greig, et al., A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase, Current medical research and opinion 17(3) (2001)1 59-165.[24] A. Ferreira, et al., Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology, Phytochemistry reviews 15(1) (2016) 51-85. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11101-014-9384-y.",{"VI":943}," Comparing Acetylcholinesterase and Butyrylcholinesterase Inhibition Effect of Total Extract and Fractions with Alcaloid-Rich Extract of Huperzia Serrata (Thunb.) 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