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nodules of the thyroid, AJR Am J Roentgenol, 178, 687, 10.2214\u002Fajr.178.3.1780687\nLang, 2006, Classical and follicular variant of papillary thyroid carcinoma: A comparative study on clinicopathologic features and long-term outcome, World J Surg, 30, 752, 10.1007\u002Fs00268-005-0356-7\nLiu, 2006, Follicular variant of papillary thyroid carcinoma: A clinicopathologic study of a problematic entity, Cancer, 107, 1255, 10.1002\u002Fcncr.22138\nLloyd, 2004, Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma, Am J Surg Pathol, 28, 1336, 10.1097\u002F01.pas.0000135519.34847.f6\nMoon, 2015, BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence\u002Frecurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area, Head Neck, 37, 1432, 10.1002\u002Fhed.23770\nNechifor-Boila, 2013, Immunohistochemical markers in the diagnosis of papillary thyroid carcinomas: The promising role of combined immunostaining using HBME-1 and CD56, Pathol Res Pract, 209, 585, 10.1016\u002Fj.prp.2013.06.012\nOzdemir, 2011, Classical and follicular variant papillary thyroid carcinoma: Comparison of clinical, ultrasonographical, cytological, and histopathological features in 444 patients, Endocr Pathol, 22, 58, 10.1007\u002Fs12022-011-9160-0\nRago, 2007, Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hürthle cell thyroid lesions: Results from a series of 505 consecutive patients, Clin Endocrinol (Oxf), 66, 13\nRenshaw, 2002, Why there is the tendency to “overdiagnose” the follicular variant of papillary thyroid carcinoma, Am J Clin Pathol, 117, 19, 10.1309\u002FCJEU-XLQ7-UPVE-NWFV\nRenshaw, 2013, Can changing the terminology for benign aspirates reduce the atypia of undetermined significance\u002Ffollicular lesion of undetermined significance rate in thyroid fine-needle aspirates?, Cancer Cytopathology, 121, 175, 10.1002\u002Fcncy.21236\nRhee, 2014, Follicular variant of papillary thyroid carcinoma: Distinct biologic behavior based on ultrasonographic features, Thyroid, 24, 683, 10.1089\u002Fthy.2013.0351\nRosai, 2010, The encapsulated follicular variant of papillary thyroid carcinoma: Back to the drawing board, Endocr Pathol, 21, 7, 10.1007\u002Fs12022-009-9103-1\nShih, 2005, Follicular variant of papillary thyroid carcinoma: Diagnostic limitations of fine needle aspiration cytology, Acta Cytol, 49, 383, 10.1159\u002F000326170\nSuen, 1997, Guidelines of the Papanicolaou Society of Cytopathology for fine-needle aspiration procedure and reporting, Diagn Cytopathol, 17, 239, 10.1002\u002F(SICI)1097-0339(199710)17:4\u003C239::AID-DC1>3.0.CO;2-7\nTuttle, 2010, Thyroid, 20, 1341, 10.1089\u002Fthy.2010.0178\nUstun, 2014, Follicular variant of papillary thyroid carcinoma: Accuracy of FNA diagnosis and implications for patient management, Endocr Pathol, 25, 257, 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1996, Nonlinear behavior of an ultrasonic transducer, Ultrasonics, 34, 187, 10.1016\u002F0041-624X(95)00077-G\nAverkiou, 1997, Nonlinear distortion of short pulses radiated by plane and focused circular pistons, J Acoust Soc Am, 102, 2539, 10.1121\u002F1.420308\nBaker, 1992, Distortion and high-frequency generation due to nonlinear propagation of short ultrasonic pulses from a plane circular piston, J Acoust Soc Am, 92, 1699, 10.1121\u002F1.403909\nBell SA. A beginner's guide to uncertainty of measurement.2001.\nBeyer, 1960, Parameter of nonlinearity in fluids, J Acoust Soc Am, 32, 719, 10.1121\u002F1.1908195\nBjørnø, 1986, Characterization of biological media by means of their non-linearity, Ultrasonics, 24, 254, 10.1016\u002F0041-624X(86)90102-2\nBjørnø, 2002, Forty years of nonlinear ultrasound, Ultrasonics, 40, 11, 10.1016\u002FS0041-624X(02)00084-7\nCobb, 1983, Finite amplitude method for the determination of the acoustic nonlinearity parameter B\u002FA, J Acoust Soc Am, 73, 1525, 10.1121\u002F1.389413\nCobbold, 2006\nCoppens, 1965, Parameter of nonlinearity in fluids II, J Acoust Soc Am, 38, 797, 10.1121\u002F1.1909806\nCurra, 2000, Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound, IEEE Trans Ultrason Ferroelectr Freq Control, 47, 1077, 10.1109\u002F58.852092\nDong, 1999, Nonlinearity parameter for tissue-mimicking materials, Ultrasound Med Biol, 25, 831, 10.1016\u002FS0301-5629(99)00016-2\nDuck, 2002, Nonlinear acoustics in diagnostic ultrasound, Ultrasound Med Biol, 28, 1, 10.1016\u002FS0301-5629(01)00463-X\nGong, 1984, Ultrasonic investigation of the nonlinearity parameter B\u002FA in biological media, J Acoust Soc Am, 76, 949, 10.1121\u002F1.391277\nGong, 1989, Determination of the acoustic nonlinearity parameter in biological media using FAIS and ITD methods, J Acoust Soc Am, 86, 1, 10.1121\u002F1.398326\nHagelberg, 1967, Calculation of B\u002FA for water from measurements of ultrasonic velocity versus temperature and pressure to 10 000 kg\u002Fcm2, J Acoust Soc Am, 41, 564, 10.1121\u002F1.1910380\nHamilton, 1998\nHart, 1988, Nonlinear effects in focused sound beams, J Acoust Soc Am, 84, 1488, 10.1121\u002F1.396595\nInternational Electrotechnical Commission (IEC). 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10.1006\u002Fabbi.1999.1197\nCherin, 1998, Evaluation of acoustical parameter sensitivity to age-related and osteoarthritic changes in articular cartilage using 50-MHz ultrasound, Ultrasound Med Biol, 24, 341, 10.1016\u002FS0301-5629(97)00289-5\nDuke, 1999, Exposure to altered gravity affects all stages of endochondral cartilage differentiation, Adv Space Res, 24, 821, 10.1016\u002FS0273-1177(99)00077-0\nFincke, 2005, Evaluation of shoulder integrity in space: first report of musculoskeletal US on the International Space Station, Radiology, 234, 319, 10.1148\u002Fradiol.2342041680\nFoster, 2000, Advances in ultrasound biomicroscopy, Ultrasound Med Biol, 26, 1, 10.1016\u002FS0301-5629(99)00096-4\nGardner, 1971, Living articular cartilage is not smooth: The structure of mammalian and avian joint surfaces demonstrated in vivo by immersion incident light microscopy, Ann Rheum Dis, 30, 3, 10.1136\u002Fard.30.1.3\nGlobus, 1986, The temporal response of bone to unloading, Endocrinology, 118, 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10.1118\u002F1.4808149\nKrasovitski, 2011, Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects, Proc Natl Acad Sci USA, 108, 3258, 10.1073\u002Fpnas.1015771108\nKumon, 2009, Spatiotemporal effects of sonoporation measured by real-time calcium imaging, Ultrasound Med Biol, 35, 494, 10.1016\u002Fj.ultrasmedbio.2008.09.003\nLeighton, 1994\nLeslie, 2007, High intensity focused ultrasound in the treatment of abdominal and gynaecological diseases, Int J Hyperthermia, 23, 173, 10.1080\u002F02656730601150514\nLi, 2014, Passive cavitation detection during pulsed HIFU exposures of ex vivo tissues and in vivo mouse pancreatic tumors, Ultrasound Med Biol, 40, 1523, 10.1016\u002Fj.ultrasmedbio.2014.01.007\nMorris, 2007, Nav Channel Mechanosensitivity: Activation and inactivation accelerate reversibly with stretch, Biophys J, 93, 822, 10.1529\u002Fbiophysj.106.101246\nMortimer, 1988, The effect of therapeutic ultrasound on calcium uptake in fibroblasts, Ultrasound Med 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from bovine adrenal chromaffin cells by microsecond bursts of therapeutic levels of ultrasound, J Physiol, 492, 257, 10.1113\u002Fjphysiol.1996.sp021306\nRorsman, 2003, Insulin granule dynamics in pancreatic beta cells, Diabetologia, 46, 1029, 10.1007\u002Fs00125-003-1153-1\nSakurada, 1993, Relation between glucose-stimulated insulin secretion and intracellular calcium accumulation studied with a superfusion system of a glucose-responsive pancreatic beta-cell line MIN6, Endocrinology, 132, 2659, 10.1210\u002Fendo.132.6.8504766\nSchlicher, 2006, Mechanism of intracellular delivery by acoustic cavitation, Ultrasound Med Biol, 32, 915, 10.1016\u002Fj.ultrasmedbio.2006.02.1416\nSemino, 1990, Early changes in the rat pancreatic B cell size induced by glucose, Cells Tissues Organs, 138, 293, 10.1159\u002F000146958\nSpellman, 2007, Islet cell dysfunction in progression to diabetes mellitus, J Am Osteopath Assoc, 107, S1\nSuarez Castellanos, 2016, Therapeutic modulation of calcium dyanamis using ultrasound and other energy-based techniques, IEEE Rev Biomed Eng, 9, 177, 10.1109\u002FRBME.2016.2555760\nTakii, 2006, Involvement of stretch-activated cation channels in hypotonically induced insulin secretion in rat pancreatic B-cells, Am J Physiol Cell Physiol, 291, 1405, 10.1152\u002Fajpcell.00519.2005\nTennant, 1964, Evaluation of the trypan blue technique for determination of cell viability, Transplantation, 2, 685, 10.1097\u002F00007890-196411000-00001\nTsukamoto, 2011, Stable cavitation induces increased cytoplasmic calcium in L929 fibroblasts exposed to 1-MHz pulsed ultrasound, Ultrasonics, 51, 982, 10.1016\u002Fj.ultras.2011.05.014\nTyler, 2008, Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound, PLoS One, 3, e3511, 10.1371\u002Fjournal.pone.0003511\nWheeler, 1996, Characterization of SNARE protein expression in beta cell lines and pancreatic islets, Endocrinology, 137, 1340, 10.1210\u002Fendo.137.4.8625909\nWild, 2004, Estimates for 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coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. 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2007, Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells, Cancer Cell, 13, 193, 10.1016\u002Fj.ccr.2007.11.032\nBernsen, 1999, A quantitative analysis of vascularization and perfusion of human glioma xenografts at different implantation sites, Microvasc Res, 57, 2442, 10.1006\u002Fmvre.1999.2143\nBernsen, 1995, Vascularity and perfusion of human gliomas xenografted in the athymic nude-mouse, Br J Cancer, 71, 721, 10.1038\u002Fbjc.1995.141\nBussink, 1999, Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts, effects of carbogen and nicotinamide, Radiother Oncol, 50, 173, 10.1016\u002FS0167-8140(99)00010-9\nChen, 2011, Vasculatures in tumors growing from preirradiated tissues: formed by vasculogenesis and resistant to radiation and antiangiogenic therapy, Int J Radiat Oncol Biol Phys, 80, 1515, 10.1016\u002Fj.ijrobp.2011.02.055\nChen, 2011, Assessment of tumor vasculature for diagnostic and therapeutic applications in a mouse model in vivo using 25-MHz power Doppler imaging, Ultrasonics, 51, 925, 10.1016\u002Fj.ultras.2011.05.007\nClifton, 1975, Mammary carcinoma cell population growth in preirradiated and unirradiated transplant sites. Viable tumor growth, vascularity, and tumor-bed effect, Radiology, 117, 459, 10.1148\u002F117.2.459\nDenis, 2002, In vivo quantitation of tumour vascularisation assessed by Doppler sonography in rat mammary tumours, Ultrasound Med Biol, 28, 431, 10.1016\u002FS0301-5629(02)00478-7\nFoster, 2000, Advances in ultrasound biomicroscopy, Ultrasound Med Biol, 26, 1, 10.1016\u002FS0301-5629(99)00096-4\nFoster, 2002, A new ultrasound instrument for in vivo microimaging of mice, Ultrasound Med Biol, 28, 1165, 10.1016\u002FS0301-5629(02)00567-7\nGee, 2001, Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations, Cancer Res, 61, 2974\nGoertz, 2000, High-frequency color flow imaging of the microcirculation, Ultrasound Med Biol, 26, 63, 10.1016\u002FS0301-5629(99)00101-5\nGoertz, 2002, High-frequency Doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow, Cancer Res, 62, 6371\nGoertz, 2003, High-frequency 3-D color-flow imaging of the microcirculation, Ultrasound Med Biol, 29, 39, 10.1016\u002FS0301-5629(02)00682-8\nGreenfield, 2010, Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas, J Clin Invest, 120, 663, 10.1172\u002FJCI42345\nJugold, 2008, Volumetric high-frequency Doppler ultrasound enables the assessment of early antiangiogenic therapy effects on tumor xenografts in nude mice, Eur Radiol, 18, 753, 10.1007\u002Fs00330-007-0825-5\nKao, 2003, Reirradiation of recurrent and second primary head and neck malignancies: a comprehensive review, Cancer Treat Rev, 29, 21, 10.1016\u002FS0305-7372(02)00096-8\nKioi, 2010, Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice, J Clin Invest, 120, 694, 10.1172\u002FJCI40283\nKozin, 2007, Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors, Cancer Res, 67, 5076, 10.1158\u002F0008-5472.CAN-06-3664\nKruse, 1998, A swept-scanning mode for estimation of blood velocity in the microvasculature, IEEE Trans Ultrason Ferroelectr Freq Control, 45, 1437, 10.1109\u002F58.738282\nKuwa, 2006, Use of power Doppler ultrasound to monitor renal perfusion during burn shock, Burns, 32, 706, 10.1016\u002Fj.burns.2006.01.017\nLunt, 2009, The tumor microenvironment and metastatic disease, Clin Exp Metastasis, 26, 19, 10.1007\u002Fs10585-008-9182-2\nMenon, 2005, Tumor oxygenation status as a prognostic marker, Cancer Lett, 221, 225, 10.1016\u002Fj.canlet.2004.06.029\nMenon, 2003, An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model, Cancer Res, 63, 7232\nMilas, 1988, Effect of radiation-induced injury of tumor bed stroma on metastatic spread of murine sarcomas and carcinomas, Cancer Res, 48, 2116\nMilas, 1986, Retardation of tumor-growth in mice caused by radiation-induced injury of tumor bed stroma - dependency on tumor type, Cancer Res, 46, 723\nOhlerth, 2010, Correlation of quantified contrast-enhanced power Doppler ultrasonography with immunofluorescent analysis of microvessel density in spontaneous canine tumours, Vet J, 183, 58, 10.1016\u002Fj.tvjl.2008.08.026\nPhoon, 2000, 40 MHz Doppler characterization of umbilical and dorsal aortic blood flow in the early mouse embryo, Ultrasound Med Biol, 26, 1275, 10.1016\u002FS0301-5629(00)00278-7\nRofstad, 2005, The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products, Cancer Res, 65, 2387, 10.1158\u002F0008-5472.CAN-04-3039\nSehgal, 2000, Quantitative vascularity of breast masses by Doppler imaging: regional variations and diagnostic implications, J Ultrasound Med, 19, 427, 10.7863\u002Fjum.2000.19.7.427\nSehgal, 2001, Renal blood flow changes induced with endothelin-1 and fenoldopam mesylate at quantitative Doppler US: initial results in a canine study, Radiology, 219, 419, 10.1148\u002Fradiology.219.2.r01ma13419\nSmith, 1988, Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours, Br J Cancer, 57, 247, 10.1038\u002Fbjc.1988.54\nStewart, 1996, Vascular endothelial platelet endothelial adhesion molecule-1 (PECAM-1) expression is decreased by TNF-alpha and IFN-gamma. Evidence for cytokine-induced destabilization of messenger ribonucleic acid transcripts in bovine endothelial cells, J Immunol, 156, 1221, 10.4049\u002Fjimmunol.156.3.1221\nTamsel, 2006, The potential value of power Doppler ultrasound imaging compared with grey-scale ultrasound findings in the diagnosis of local recurrence after radical prostatectomy, Clin Radiol, 61, 325, 10.1016\u002Fj.crad.2005.12.011\nTong, 1998, Intra- and inter-observer variability and reliability of prostate volume measurement via two-dimensional and three-dimensional ultrasound imaging, Ultrasound Med Biol, 24, 673, 10.1016\u002FS0301-5629(98)00039-8\nTredan, 2007, Drug resistance and the solid tumor microenvironment, J Natl Cancer Inst, 99, 1441, 10.1093\u002Fjnci\u002Fdjm135\nTrotter, 1990, Effect of vascular marker Hoechst 33342 on tumour perfusion and cardiovascular function in the mouse, Br J Cancer, 62, 903, 10.1038\u002Fbjc.1990.406\nTsai, 2007, Macrophages from irradiated tumors express higher levels of 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Miner Res, 2, 595, 10.1002\u002Fjbmr.5650020617\nRobey, 1999, Cellular mechanisms of bone loss, 145\nRoux, 2001, Ultrasonic backscatter and transmission parameters at the os calcis in postmenopausal osteoporosis, J Bone Miner Res, 16, 1353, 10.1359\u002Fjbmr.2001.16.7.1353\nSaadé, 2006, Understanding velocity of sound in trabecular bone via computer simulations, Comput Biol Med, 36, 439, 10.1016\u002Fj.compbiomed.2005.03.008\nSchnitzler, 1998, Bone marrow composition and bone microarchitecture and turnover in blacks and whites, J Bone Miner Res, 13, 1300, 10.1359\u002Fjbmr.1998.13.8.1300\nSerpe, 1996, The nonlinear transition period of broadband ultrasound attenuation as bone density varies, J Biomech, 29, 963, 10.1016\u002F0021-9290(95)00146-8\nStrelitzki, 1998, A model for ultrasonic scattering in cancellous bone based on velocity fluctuations in a binary mixture, Physiol Meas, 19, 189, 10.1088\u002F0967-3334\u002F19\u002F2\u002F006\nTöyräs, 2002, Bone mineral density, ultrasound 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