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The specific endpoints assessed in this meta‐analysis include the total blood loss, the incidence rate of deep vein thrombosis (\u003Cjats:styled-content style=\"fixed-case\">DVT\u003C\u002Fjats:styled-content>) and pulmonary embolisms (\u003Cjats:styled-content style=\"fixed-case\">PE\u003C\u002Fjats:styled-content>), the number of patients requiring at least 1 U of red blood cell following surgery.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>The prevalence of \u003Cjats:styled-content style=\"fixed-case\">THA\u003C\u002Fjats:styled-content> and \u003Cjats:styled-content style=\"fixed-case\">TKA\u003C\u002Fjats:styled-content> is increasing and both are usually accompanied by considerable blood loss. \u003Cjats:styled-content style=\"fixed-case\">TXA\u003C\u002Fjats:styled-content> has been reported to reduce total blood loss in many orthopaedic surgeries. \u003Cjats:styled-content style=\"fixed-case\">TXA\u003C\u002Fjats:styled-content> administration continues to be a controversial topic in the literature about joint arthroplasty, and many studies have reported substantial doubt with respect to its benefits and safety.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u002Fmaterials\u003C\u002Fjats:title>\u003Cjats:p>We conducted a meta‐analysis that combined all data from available randomised controlled trials, regardless the methods of \u003Cjats:styled-content style=\"fixed-case\">TXA\u003C\u002Fjats:styled-content> administration, which included administrated intravenously, intra‐articularly, topically or orally. Finally, available data from the 39 included trials were pooled for analysis. Then, mean differences with 95% confidence intervals (\u003Cjats:styled-content style=\"fixed-case\">CIs\u003C\u002Fjats:styled-content>) was calculated for continuous outcomes and relative risks with 95% \u003Cjats:styled-content style=\"fixed-case\">CIs\u003C\u002Fjats:styled-content> for dichotomous outcomes.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>This meta‐analysis suggests that the administration of \u003Cjats:styled-content style=\"fixed-case\">TXA\u003C\u002Fjats:styled-content> significantly reduced blood loss and the need for allogeneic blood transfusion, without apparent increased risk of \u003Cjats:styled-content style=\"fixed-case\">DVT\u003C\u002Fjats:styled-content> or \u003Cjats:styled-content style=\"fixed-case\">PE\u003C\u002Fjats:styled-content> thromboembolic complications.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>To our knowledge, this meta‐analysis is more powerful and persuasive than any other published before. It suggests that the use of \u003Cjats:styled-content style=\"fixed-case\">TXA\u003C\u002Fjats:styled-content> reduced the risk of blood loss and the need for allogeneic blood transfusion significantly, without apparent increased risk of \u003Cjats:styled-content style=\"fixed-case\">DVT\u003C\u002Fjats:styled-content> or \u003Cjats:styled-content style=\"fixed-case\">PE\u003C\u002Fjats:styled-content> complications.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":101},"The effectiveness and safety of tranexamic acid in total hip or knee arthroplasty: a meta‐analysis of 2720 cases",{"VOID":103},"26033447",{"VOID":105},"10.1111\u002Ftme.12212","PUBLICATION","VERIFIED","Auto Verify",[110],"EN","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Ftme.12212",[113,132],{"id":114,"sortIndex":25,"researcher":24,"roles":115,"affiliations":116,"properties":125,"displayName":129,"givenName":24,"familyName":24},"26a75445-4711-498e-87af-e112e18cc687",[],[117],{"id":118,"sortIndex":25,"affiliation":119,"properties":24},"0445c1db-50ea-44ab-bd8e-8dbd017cc63c",{"id":118,"createTime":24,"updateTime":24,"relativeEntities":120,"slug":24,"properties":121,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":124,"statistic":24},[],{"title":122},{"EN":123},"Department of Trauma, Union Medicine Centre of Tianjin, Tianjin, China",[],{"orcid":126,"title":128,"openalex":130},{"VOID":127},"https:\u002F\u002Forcid.org\u002F0000-0002-5949-0994",{"EN":129},"Zhenhong Wei",{"VOID":131},"A5032116592",{"id":133,"sortIndex":134,"researcher":24,"roles":135,"affiliations":136,"properties":143,"displayName":145,"givenName":24,"familyName":24},"e3e6944d-2a2e-45d5-9d07-f224a318e4e2",1,[],[137],{"id":118,"sortIndex":25,"affiliation":138,"properties":24},{"id":118,"createTime":24,"updateTime":24,"relativeEntities":139,"slug":24,"properties":140,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":142,"statistic":24},[],{"title":141},{"EN":123},[],{"title":144,"openalex":146},{"EN":145},"M. 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The goal of this research was to study the safety and the efficacy of transfusing citrate‐phosphate‐adenine anticoagulant‐preservative (CPDA‐1) RBC stored for up to 28 days to reduce donor exposures in premature infants. A prospective randomized two‐group study was conducted with very low‐birth‐weight premature infants that received at least one RBC transfusion during hospital stay. Neonates randomly assigned to Group 1 (26 infants) were transfused with CPDA‐1 RBC stored for up to 28 days; those assigned to Group 2 (26 infants) received CPDA‐1 RBC stored for up to 3 days. Demographic and transfusion‐related data were collected. Neonates from both groups showed similar demographics and clinical characteristics. The number of transfusions per infant transfused was 4·4 ± 4·0 in Group 1 and 4·2 ± 3·1 in Group 2, and the number of donors per infant transfused was 1·5 ± 0·8 (Group 1) and 4·3 ± 3·4 (Group 2), \u003Cjats:italic>P\u003C\u002Fjats:italic> < 0·001. RBC transfusions containing 29·7 ± 18·3 mmol L\u003Cjats:sup>−1\u003C\u002Fjats:sup> of potassium (RBC stored for up to 28 days) did not cause clinical or biochemical changes and reduced donor exposures by 70·2%, compared to transfusions containing 19·8 ± 12·3 mmol L\u003Cjats:sup>−1\u003C\u002Fjats:sup> of potassium (RBC stored for up to 3 days), \u003Cjats:italic>P\u003C\u002Fjats:italic> < 0·001. In conclusion, RBC stored for up to 28 days safely reduced donor exposures in premature infants.\u003C\u002Fjats:p>",{"EN":392},"Transfusions of CPDA‐1 red blood cells stored for up to 28 days decrease donor exposures in very low‐birth‐weight premature 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evaluated whole blood integral filtration to produce leucocyte‐depleted red cells and plasma by using the WBF1 whole blood filter (Pall Medsep). Whole blood units were filtered after either warm (2–4 h at room temperature) or cold (12–24 h at 4 °C) holds. Filtered and control units were processed using either a bottom‐and‐top or top‐top method. Red cells were tested weekly for 6 weeks, and plasma 3 monthly for 12 months. All filtered red‐cell packs contained < 5 × 10\u003Cjats:sup>6\u003C\u002Fjats:sup> leucocytes\u002Funit with 71 of 72 containing < 1 × 10\u003Cjats:sup>6\u003C\u002Fjats:sup> leucocytes\u002Funit. No clinically significant differences in red‐cell storage parameters were seen, although haemolysis was less and \u003Cjats:italic>p\u003C\u002Fjats:italic>O\u003Cjats:sub>2\u003C\u002Fjats:sub>\u002F\u003Cjats:italic>p\u003C\u002Fjats:italic>CO\u003Cjats:sub>2\u003C\u002Fjats:sub> values were better maintained in filtered units. 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Winter M.A. Payrat J.‐M. Mathias J.‐M. Pamphilon D.H.(in press)Leucocytes can be eliminated from plasma by filtration prior to viral inactivation with methylene blue.Vox Sanguinis.",{},{"id":24,"text":926,"url":24,"identifiers":927},"10.1046\u002Fj.1537-2995.1997.371098016442.x",{"doi":926},{"id":24,"text":929,"url":24,"identifiers":930},"10.1111\u002Fj.1423-0410.1995.tb02594.x",{"doi":929},{"id":24,"text":932,"url":24,"identifiers":933},"Schleuning M., 1992, Complement activation during storage of blood under normal blood bank conditions. 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Brand A.(1996) Leucocyte depletion reduces postoperative mortality in patients undergoing cardiac surgery.Abstract SY3DI‐06 24th Congress International Society of Blood Transfusion Japan.",{},{"id":24,"text":948,"url":24,"identifiers":949},"Williamson L.M., 1994, Bedside filtration of blood products in the prevention of HLA alloimmunisation — a prospective randomised study, Blood, 83, 3028, 10.1182\u002Fblood.V83.10.3028.3028",{"doi":950},"10.1182\u002Fblood.V83.10.3028.3028",{"id":952,"createTime":953,"updateTime":953,"relativeEntities":954,"slug":955,"properties":956,"entityType":106,"verifyStatus":107,"verifyTime":953,"verifyNote":108,"languages":969,"translateLanguages":24,"viewCount":25,"primaryUrl":970,"fullTextUrl":24,"authors":971,"publicationType":148,"publisherRelationship":1042,"citationCount":1088,"citationInfo":1089,"publishDate":1097,"publishYear":1090,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1098,"openAccess":24,"references":1099,"isForceReanalyzing":378},"da16b1e6-bfb2-489b-bc7c-78d0b26cf3be","2024-10-10T10:23:33.898+00:00",[],"Red-blood-cell-storage-and-cell-morphology",{"openalex":957,"mag":959,"abstract":961,"title":963,"pm":965,"doi":967},{"VOID":958},"W2161889928",{"VOID":960},"2161889928",{"EN":962},"\u003Cjats:p>\u003Cjats:bold>Aim:\u003C\u002Fjats:bold> In this study, we performed weekly assessment of morphology‐related parameters through monitoring of CPD‐SAGM leuco‐filtered erythrocyte concentrates from blood withdrawal until the 42nd day of storage.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Background:\u003C\u002Fjats:bold> Liquid storage of red blood cells (RBCs) delivers a blood‐derived therapeutic, which is safe, available, effective and affordable for most patients who need transfusion therapy in developed countries. However, a growing body of accumulating controversial evidences, from either biochemical or retrospective clinical studies, prompted safety concerns about longer stored RBCs.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Methods:\u003C\u002Fjats:bold> Statistical image analysis through scanning electron microscope was coupled to osmotic fragility and erythrocyte sedimentation rate.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Results:\u003C\u002Fjats:bold> We could observe that by day 21 more than 50% of RBCs displayed non‐discocyte phenotypes. This observation was related to an increase in osmotic fragility, which was totally overlapped in day 0 controls and day 7 RBCs while only slightly augmented in day 14 samples. 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722",{},{"id":24,"text":1216,"url":24,"identifiers":1217},"10.1046\u002Fj.1537-2995.1979.19279160297.x",{"doi":1216},{"id":1219,"createTime":1220,"updateTime":1220,"relativeEntities":1221,"slug":1222,"properties":1223,"entityType":106,"verifyStatus":107,"verifyTime":1220,"verifyNote":108,"languages":1236,"translateLanguages":24,"viewCount":25,"primaryUrl":1237,"fullTextUrl":24,"authors":1238,"publicationType":148,"publisherRelationship":1277,"citationCount":1323,"citationInfo":1324,"publishDate":1327,"publishYear":1325,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1328,"openAccess":24,"references":1329,"isForceReanalyzing":378},"8c34185b-7dc3-4155-bd0e-108ccf40b8ac","2024-10-09T23:32:15.337+00:00",[],"Transfusion-transmitted-scp-CMV-scp-infection-current-knowledge-and-future-perspectives",{"openalex":1224,"mag":1226,"abstract":1228,"title":1230,"pm":1232,"doi":1234},{"VOID":1225},"W2702060047",{"VOID":1227},"2702060047",{"EN":1229},"\u003Cjats:title>SUMMARY\u003C\u002Fjats:title>\u003Cjats:p>Transmission of human cytomegalovirus (\u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content>) via transfusion (\u003Cjats:styled-content style=\"fixed-case\">TT‐CMV\u003C\u002Fjats:styled-content>) may still occur and remains a challenge in the treatment of immunocompromised \u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content>‐seronegative patients, e.g. after stem cell transplantation, and for low birthweight infants. Measures to reduce the risk of \u003Cjats:styled-content style=\"fixed-case\">TT‐CMV\u003C\u002Fjats:styled-content> have been evaluated in clinical studies, including leucocyte depletion of cellular blood products and\u002For the selection of \u003Cjats:styled-content style=\"fixed-case\">CMV‐IgG\u003C\u002Fjats:styled-content>‐negative donations. Studies in large blood donor cohorts indicate that donations from newly \u003Cjats:styled-content style=\"fixed-case\">CMV‐IgG\u003C\u002Fjats:styled-content>‐positive donors should bear the highest risk for transmitting \u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content> infections because they contain the highest levels of \u003Cjats:styled-content style=\"fixed-case\">CMV‐DNA\u003C\u002Fjats:styled-content>, and early \u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content> antibodies cannot neutralise \u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content>. Based on this knowledge, rational strategies to reduce the residual risk of \u003Cjats:styled-content style=\"fixed-case\">TT‐CMV\u003C\u002Fjats:styled-content> using leucoreduced blood products could be designed. However, there is a lack of evidence that \u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content> is still transmitted by transfusion of leucoreduced units. In low birthweight infants, most (if not all) \u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content> infections are caused by breast milk feeding or congenital transmission rather than by transfusion of leucoreduced blood products. For other patients at risk, no definitive data exist about the relative importance of alternative transmission routes of \u003Cjats:styled-content style=\"fixed-case\">CMV\u003C\u002Fjats:styled-content> compared to blood transfusion. As a result, only the conduction of well‐designed studies addressing strategies to prevent \u003Cjats:styled-content style=\"fixed-case\">TT‐CMV\u003C\u002Fjats:styled-content> and the thorough examination of presumed cases of \u003Cjats:styled-content style=\"fixed-case\">TT‐CMV\u003C\u002Fjats:styled-content> will achieve guidance for the best transfusion regimen in patients at risk.\u003C\u002Fjats:p>",{"EN":1231},"Transfusion‐transmitted \u003Cscp>CMV\u003C\u002Fscp> infection – current knowledge and future 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assess the value of patient blood management (PBM) in the detection and management of preoperative anaemia before elective surgery.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>PBM is recognised as the standard of care, with diagnosis and management of preoperative anaemia being the key components of PBM. No formal assessment of the value of PBM anaemia screening and correction before scheduled surgery had been made at our hospital.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>We conducted a retrospective study in a tertiary‐care, academic hospital of consecutive records of elective surgery (\u003Cjats:italic>n\u003C\u002Fjats:italic> = 25 641). We excluded minor surgeries. We identified anaemic patients who had been assessed by PBM or not (non‐PBM). We calculated transfusion incidence and hospital length of stay (LOS) across all surgical specialities.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>During the 1‐year study period, 15 245 patients were eligible for inclusion; 311 patients (2·0%) were transfused, and 83·3% of transfusions were in anaemic patients. Transfusion incidence was 9·2% in anaemic PBM‐assessed patients and 17·4% in non‐PBM patients. For haemoglobin (Hb) <100 g L\u003Cjats:sup>−1\u003C\u002Fjats:sup>, the transfusion incidence was 22·1% [95% confidence interval (CI) 15·5–30·6%] in PBM and 40·0% (95% CI 35·1–45·0%) in non‐PBM patients, and for Hb 100–119 g L\u003Cjats:sup>−1\u003C\u002Fjats:sup>, it was 4·7% (95% CI 2·8–7·5%) and 7·9% (95% CI 6·3–9·8%), respectively. Overall mean LOS was 2·1 days [standard deviation (SD) 6·0]. Mean LOS with Hb <100 g L\u003Cjats:sup>−1\u003C\u002Fjats:sup> was 6·7 days (SD 14·8) in PBM‐assessed patients and 12·4 days (SD 19·5) in non‐PBM patients and was 3·1 (SD 5·2) and 6·2 (SD 9·5) days, respectively, for Hb 100–119 g L\u003Cjats:sup>−1\u003C\u002Fjats:sup>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>Anaemic elective surgery patients assessed by patient blood management (PBM) had a markedly lower  transfusion risk and shorter LOS than anaemic patients not assessed by PBM.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1561},"Transfusion requirement and length of stay of anaemic surgical patients associated with a patient blood management service:a single‐Centre retrospective study",{"VOID":1563},"31327171",{"VOID":1565},"10.1111\u002Ftme.12617",[110],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Ftme.12617",[1569,1588,1605],{"id":1570,"sortIndex":25,"researcher":24,"roles":1571,"affiliations":1572,"properties":1581,"displayName":1585,"givenName":24,"familyName":24},"5c49bdfe-18e2-4417-8f8d-7059a22d0df9",[],[1573],{"id":1574,"sortIndex":25,"affiliation":1575,"properties":24},"088542de-c34f-43f8-97e4-5115be99cb6e",{"id":1574,"createTime":24,"updateTime":24,"relativeEntities":1576,"slug":24,"properties":1577,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1580,"statistic":24},[],{"title":1578},{"EN":1579},"Patient Blood Management, Royal Cornwall Hospital NHS Trust, Cornwall, UK",[],{"orcid":1582,"title":1584,"openalex":1586},{"VOID":1583},"https:\u002F\u002Forcid.org\u002F0000-0001-7904-4601",{"EN":1585},"J. 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Di(2‐ethylhexyl)phthalate (DEHP) is present in many industrial and domestic products, and is a common plasticiser used in blood bags and tubing sets. Concerns have been raised by environmental groups that DEHP exposure may result in gender birth defects and the feminisation of boys although there were no studies performed of intravenous exposure to DEHP on higher mammals or humans which report similar effects.\u003C\u002Fjats:p>\u003Cjats:p>This article reports on the toxicology of DEHP and considers concerns regarding its use in the context of transfusion medicine. The benefits of using DEHP are evaluated and the use of alternative plasticisers to DEHP is explored. The article reports on international and European regulatory recommendations for DEHP use in transfusion medicine and examines the impact of legislation on the medical devices and blood industries. 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URLhttps:\u002F\u002Fwww.cen.eu\u002Fcen\u002FSectors\u002FSectors\u002FHealthcare\u002FPages\u002Fdefault.aspx(Accessed 15\u002F7\u002F10).",{},{"id":24,"text":1884,"url":24,"identifiers":1885},"10.1080\u002F01926230152500040",{"doi":1884},{"id":24,"text":1887,"url":24,"identifiers":1888},"Eucomed(2006)Eucomed position on the use of DEHP‐plasticized PVC in medical products[WWW document]. URLhttp:\u002F\u002Fwww.eucomed.be\u002Fupload\u002Fpdf\u002Ftl\u002F2006\u002Fportal\u002Fpublications\u002Fposition_papers\u002F2006‐09_dehp‐pvc_in_medical_products.pdf(Accessed 15\u002F7\u002F10).",{},{"id":24,"text":1890,"url":24,"identifiers":1891},"European Commission(1993)Official Journal of the European Union. Council Directive 93\u002F42\u002FEEC of 14 June 1993 concerning medical devices[WWW document]. URLhttp:\u002F\u002Feurlex.europa.eu\u002FLexUriServ\u002FLexUriServ.do?uri=CELEX:31993L0042:EN:HTML(Accessed 15\u002F7\u002F10).",{},{"id":24,"text":1893,"url":24,"identifiers":1894},"European Commission(1967)Council Directive 67\u002F548\u002FEEC of 27 June 1967 on the approximation of laws regulations and administrative provisions relating to the classification packaging and labelling of dangerous substrates. Annex 1[WWW document]. URLhttp:\u002F\u002Fwww.reach‐compliance.eu\u002Fenglish\u002Flegislation\u002Fdocs\u002Flaunchers\u002Flaunch‐annex‐1‐67‐548‐EEC.html(Accessed 19\u002F7\u002F10).",{},{"id":24,"text":1896,"url":24,"identifiers":1897},"European Commission Scientific Committee on Medicinal Products and Medical Devices (SCMPMD)(2002)Opinion on Medical Devices Containing DEHP Plasticised PVC; Neonates and Other Groups Possibly at Risk from DEHP Toxicity[WWW document]. URLhttp:\u002F\u002Fec.europa.eu\u002Fhealth\u002Fph_risk\u002Fcommittees\u002Fscmp\u002Fdocuments\u002Fout43_en.pdf(Accessed 15\u002F7\u002F10).",{},{"id":24,"text":1899,"url":24,"identifiers":1900},"European Commission Scientific Committee on Toxicity Ecotoxicity and the Environment (CSTEE)(2004)Opinion on the result of a second Risk Assessment of bis(2‐ethylhexyl)phthalate(DEHP) Human Health Part[WWW document]. URLhttp:\u002F\u002Fec.europa.eu\u002Fhealth\u002Fph_risk\u002Fcommittees\u002Fsct\u002Fdocuments\u002Fout214_en.pdf(Accessed 16\u002F7\u002F10).",{},{"id":24,"text":1902,"url":24,"identifiers":1903},"European Commission(2007a)Official Journal of the European Union. Directive 2007\u002F47\u002FEC Of The European Parliament And Of The Council of 5 September 2007[WWW document]. URLhttp:\u002F\u002Feur‐lex.europa.eu\u002FLexUriServ\u002FLexUriServ.do?uri=OJ:L:2007:247:0021:0055:EN:PDF(Accessed 15\u002F7\u002F10).",{},{"id":24,"text":1905,"url":24,"identifiers":1906},"European Commission Scientific Committee on Emerging and Newly‐Identified Health Risks (SCENIHR)(2007b)Preliminary report on the safety of medical devices containing DEHP‐plasticized PVC or other plasticizers on neonates and other groups possibly at risk[WWW document]. URLhttp:\u002F\u002Fec.europa.eu\u002Fhealth\u002Fph_risk\u002Fcommittees\u002F04_scenihr\u002Fdocs\u002Fscenihr_o_008.pdf(Accessed 15\u002F7\u002F10).",{},{"id":24,"text":1908,"url":24,"identifiers":1909},"European Commission. European Chemicals Bureau.(2008a)EUR 23384 EN\u002F2 European Union Risk Assessment Report bis (2‐ethylhexyl) phthalate (DEHP) Volume 80. Luxembourg: Office for Official Publications of the European Communities 2008 EUR–Scientific and Technical Research series–ISSN 1018–5593[WWW document]. URLhttp:\u002F\u002Fecb.jrc.ec.europa.eu\u002Fdocuments\u002FExisting‐Chemicals\u002FRISK_ASSESSMENT\u002FREPORT\u002Fdehpreport042.pdf(Accessed 16\u002F7\u002F10).",{},{"id":24,"text":1911,"url":24,"identifiers":1912},"European Commission Scientific Committee on Emerging and Newly‐Identified Health Risks (SCENIHR).(2008b)Opinion on the safety of medical devices containing DEHP‐plasticized PVC or other plasticizers on neonates and other groups possibly at risk[WWW document]. URLhttp:\u002F\u002Fec.europa.eu\u002Fhealth\u002Fph_risk\u002Fcommittees\u002F04_scenihr\u002Fdocs\u002Fscenihr_o_014.pdf(Accessed 15\u002F7\u002F10).",{},{"id":24,"text":1914,"url":24,"identifiers":1915},"European Food Safety Authority, 2005, Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to bis(2‐ethylhexyl)phthalate (DEHP) for use in food contact materials. Question N° EFSA‐Q‐2003‐191., EFSA Journal, 243, 1",{},{"id":24,"text":1917,"url":24,"identifiers":1918},"FDA.U.S. Food and Drug Administration (2002a)Medical devices made with polyvinylchloride (PVC) using the plasticiser di‐(2‐ethylhexyl) phthalate (DEHP). Draft guidance for industry and FDA Draft released for comment FDA Centre for Devices and Radiological Health.",{},{"id":24,"text":1920,"url":24,"identifiers":1921},"FDA.U.S. Food and Drug Administration (2002b)Safety assessment of di(2‐ethylhexyl) phthalate (DEHP) released from PVC medical devices FDA Centre for Devices and Radiological Health.",{},{"id":24,"text":1923,"url":24,"identifiers":1924},"10.1093\u002Ftoxsci\u002F58.2.350",{"doi":1923},{"id":24,"text":1926,"url":24,"identifiers":1927},"Health Canada Expert Advisory Panel On DEHP In Medical Devices(2002) Final Report 2002 January 11 Health Canada. Ottawa Canada[WWW document]. 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The identification of specific antimicrobial activity of intravenous immunoglobulin (IVIG) preparations against particular microbial pathogens can assist in determining their therapeutic potential for specific infectious diseases. We analysed five different commercial IVIG preparations for the presence of antibodies directed against a large panel of viral, bacterial, fungal and parasitic pathogens. All IVIG batches contained high activity against herpesviruses types 1, 2, 6 and 7, as well as against varicella zoster virus, Epstein‐Barr virus (EBV), measles, mumps, rubella and parvovirus B19. Some IVIG batches also had a significant activity against adenovirus and Saint Louis encephalitis virus. The IVIGs held high activity against several bacterial pathogens, including \u003Cjats:italic>Mycoplasma pneumonia\u003C\u002Fjats:italic>, \u003Cjats:italic>Chlamydia pneumonia\u003C\u002Fjats:italic>, \u003Cjats:italic>Helicobacter pylori\u003C\u002Fjats:italic> and tetanus. No activity was found against various parasitic and fungal pathogens. 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