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Lancet 396(10258):1204–1222\nAshina S, Mitsikostas DD, Lee MJ, Yamani N, Wang SJ, Messina R, Ashina H, Buse DC, Pozo-Rosich P, Jensen RH et al (2021) Tension-type headache. Nat Rev Dis Primers 7(1):24\nAshina S, Bendtsen L, Lyngberg AC, Lipton RB, Hajiyeva N, Jensen R (2015) Prevalence of neck pain in migraine and tension-type headache: a population study. Cephalalgia 35(3):211–219\nBlaschek A, Milde-Busch A, Straube A, Schankin C, Langhagen T, Jahn K, Schroder SA, Reiter K, von Kries R, Heinen F (2012) Self-reported muscle pain in adolescents with migraine and tension-type headache. Cephalalgia 32(3):241–249\nCharles A (2018) The pathophysiology of migraine: implications for clinical management. Lancet Neurology 17(2):174–182\nFlorencio LL, Chaves TC, Carvalho GF, Goncalves MC, Casimiro EC, Dach F, Bigal ME, Bevilaqua-Grossi D (2014) Neck pain disability is related to the frequency of migraine attacks: a cross-sectional study. Headache 54(7):1203–1210\nFerrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A, Ashina M, van den Maagdenberg A, Dodick DW (2022) Migraine. Nat Rev Dis Primers 8(1):2\nGoadsby PJ, Holland PR (2019) An update: pathophysiology of migraine. Neurol Clin 37(4):651–671\nAshina S, Bendtsen L, Ashina M (2005) Pathophysiology of tension-type headache. Curr Pain Headache Rep 9(6):415–422\nCathcart S, Winefield AH, Lushington K, Rolan P (2010) Stress and tension-type headache mechanisms. Cephalalgia 30(10):1250–1267\nMense S (2003) The pathogenesis of muscle pain. Curr Pain Headache Rep 7(6):419–425\nRusso AF, Hay DL (2022) CGRP physiology, pharmacology, and therapeutic targets: Migraine and beyond. Physiol Rev 103(2):1565–1644\nOlesen J, Burstein R, Ashina M, Tfelt-Hansen P (2009) Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurology 8(7):679–690\nBartsch T, Goadsby PJ (2003) The trigeminocervical complex and migraine: current concepts and synthesis. Curr Pain Headache Rep 7(5):371–376\nHeadache Classification Committee of the International Headache S (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 33(9):629–808\nDo TP, Heldarskard GF, Kolding LT, Hvedstrup J, Schytz HW (2018) Myofascial trigger points in migraine and tension-type headache. J Headache Pain 19(1):84\nWeidlich D, Schlaeger S, Kooijman H, Bornert P, Kirschke JS, Rummeny EJ, Haase A, Karampinos DC (2017) T(2) mapping with magnetization-prepared 3D TSE based on a modified BIR-4 T(2) preparation. NMR Biomed. 30(11)\nSollmann N, Mathonia N, Weidlich D, Bonfert M, Schroeder SA, Badura KA, Renner T, Trepte-Freisleder F, Ganter C, Krieg SM et al (2019) Quantitative magnetic resonance imaging of the upper trapezius muscles - assessment of myofascial trigger points in patients with migraine. J Headache Pain 20(1):8\nSollmann N, Schandelmaier P, Weidlich D, Borner C, Urban G, Lang M, Zimmer C, Karampinos DC, Landgraf MN, Heinen F et al (2021) Patients with episodic migraine show increased T2 values of the trapezius muscles - an investigation by quantitative high-resolution magnetic resonance imaging. Cephalalgia 41(8):934–942\nLandgraf MN, Biebl JT, Langhagen T, Hannibal I, Eggert T, Vill K, Gerstl L, Albers L, von Kries R, Straube A et al (2018) Children with migraine: Provocation of headache via pressure to myofascial trigger points in the trapezius muscle? - A prospective controlled observational study. Eur J Pain 22(2):385–392\nSollmann N, Trepte-Freisleder F, Albers L, Jung NH, Mall V, Meyer B, Heinen F, Krieg SM, Landgraf MN (2016) Magnetic stimulation of the upper trapezius muscles in patients with migraine - A pilot study. Eur J Paediatr Neurol 20(6):888–897\nRenner T, Sollmann N, Heinen F, Albers L, Trepte-Freisleder F, Klose B, Konig H, Krieg SM, Bonfert MV, Landgraf MN (2020) Alleviation of migraine symptoms by application of repetitive peripheral magnetic stimulation to myofascial trigger points of neck and shoulder muscles - A randomized trial. Sci Rep 10(1):5954\nRenner T, Sollmann N, Trepte-Freisleder F, Albers L, Mathonia NM, Bonfert MV, Konig H, Klose B, Krieg SM, Heinen F et al (2019) Repetitive Peripheral Magnetic Stimulation (rPMS) in Subjects With Migraine-Setup Presentation and Effects on Skeletal Musculature. Front Neurol 10:738\nBorner C, Staisch J, Lang M, Hauser A, Hannibal I, Huss K, Klose B, Lechner MF, Sollmann N, Heinen F et al (2022) Repetitive neuromuscular magnetic stimulation for pediatric headache disorders: muscular effects and factors affecting level of response. Brain Sci 12(7):932\nStaisch J, Borner C, Lang M, Hauser A, Hannibal I, Huss K, Klose B, Lechner MF, Sollmann N, Heinen F et al (2022) Repetitive neuromuscular magnetic stimulation in children with headache. Eur J Paediatr Neurol 39:40–48\nRuscheweyh R, Klonowski T, Gossrau G, Kraya T, Gaul C, Straube A, Jurgens TP, Scheidt J, Forderreuther S (2022) The headache registry of the German Migraine and Headache Society (DMKG): baseline data of the first 1,351 patients. J Headache Pain 23(1):74\nAlvarez DJ, Rockwell PG (2002) Trigger points: diagnosis and management. Am Fam Physician 65(4):653–660\nFernandez-de-Las-Penas C, Dommerholt J (2018) International consensus on diagnostic criteria and clinical considerations of myofascial trigger points: a Delphi study. Pain Med 19(1):142–150\nFernandez-de-Las-Penas C, Simons D, Cuadrado ML, Pareja J (2007) The role of myofascial trigger points in musculoskeletal pain syndromes of the head and neck. Curr Pain Headache Rep 11(5):365–372\nMunoz-Munoz S, Munoz-Garcia MT, Alburquerque-Sendin F, Arroyo-Morales M, Fernandez-de-las-Penas C (2012) Myofascial trigger points, pain, disability, and sleep quality in individuals with mechanical neck pain. J Manipulative Physiol Ther 35(8):608–613\nSafiri S, Kolahi AA, Hoy D, Buchbinder R, Mansournia MA, Bettampadi D, Ashrafi-Asgarabad A, Almasi-Hashiani A, Smith E, Sepidarkish M et al (2020) Global, regional, and national burden of neck pain in the general population, 1990–2017: systematic analysis of the Global Burden of Disease Study 2017. BMJ 368:m791\nSollmann N, Weidlich D, Cervantes B, Klupp E, Ganter C, Kooijman H, Rummeny EJ, Zimmer C, Kirschke JS, Karampinos DC (2019) High Isotropic Resolution T2 Mapping of the Lumbosacral Plexus with T2-Prepared 3D Turbo Spin Echo. Clin Neuroradiol 29(2):223–230\nKocer A, Kocer E, Memisogullari R, Domac FM, Yuksel H (2010) Interleukin-6 levels in tension headache patients. Clin J Pain 26(8):690–693\nNew HV, Mudge AW (1986) Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis. Nature 323(6091):809–811\nShah JP, Danoff JV, Desai MJ, Parikh S, Nakamura LY, Phillips TM, Gerber LH (2008) Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil 89(1):16–23\nCalandre EP, Hidalgo J, Garcia-Leiva JM, Rico-Villademoros F (2006) Trigger point evaluation in migraine patients: an indication of peripheral sensitization linked to migraine predisposition? Eur J Neurol 13(3):244–249\nTali D, Menahem I, Vered E, Kalichman L (2014) Upper cervical mobility, posture and myofascial trigger points in subjects with episodic migraine: Case-control study. J Bodyw Mov Ther 18(4):569–575\nMarcus DA, Scharff L, Mercer S, Turk DC (1999) Musculoskeletal abnormalities in chronic headache: a controlled comparison of headache diagnostic groups. Headache 39(1):21–27\nAlonso-Blanco C (2012) de-la-Llave-Rincon AI, Fernandez-de-las-Penas C: Muscle trigger point therapy in tension-type headache. Expert Rev Neurother 12(3):315–322\nMork H, Ashina M, Bendtsen L, Olesen J, Jensen R (2004) Possible mechanisms of pain perception in patients with episodic tension-type headache. A new experimental model of myofascial pain. Cephalalgia 24(6):466–475\nSchulze M, Kotter I, Ernemann U, Fenchel M, Tzaribatchev N, Claussen CD, Horger M (2009) MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol 192(6):1708–1716\nMcMahon CJ, Wu JS, Eisenberg RL (2010) Muscle edema. AJR Am J Roentgenol 194(4):W284–292\nHvedstrup J, Kolding LT, Younis S, Ashina M, Schytz HW (2020) Ictal neck pain investigated in the interictal state - a search for the origin of pain. Cephalalgia 40(6):614–624\nLandgraf MN, von Kries R, Heinen F, Langhagen T, Straube A, Albers L (2016) Self-reported neck and shoulder pain in adolescents is associated with episodic and chronic migraine. Cephalalgia 36(8):807–811\nLiang Z, Thomas L, Jull G, Treleaven J (2022) The neck disability index reflects allodynia and headache disability but not cervical musculoskeletal dysfunction in migraine. Phys Ther 102(5):pzac027.\nMajumdar S, Orphanoudakis SC, Gmitro A, O’Donnell M, Gore JC (1986) Errors in the measurements of T2 using multiple-echo MRI techniques. II. Effects of static field inhomogeneity. Magn Reson Med 3(4):562–574\nMajumdar S, Orphanoudakis SC, Gmitro A, O’Donnell M, Gore JC (1986) Errors in the measurements of T2 using multiple-echo MRI techniques. I. Effects of radiofrequency pulse imperfections. Magn Reson Med 3(3):397–417\nLuedtke K, May A (2017) Stratifying migraine patients based on dynamic pain provocation over the upper cervical spine. J Headache Pain 18(1):97\nAnarte-Lazo E, Carvalho GF, Schwarz A, Luedtke K, Falla D (2021) Differentiating migraine, cervicogenic headache and asymptomatic individuals based on physical examination findings: a systematic review and meta-analysis. BMC Musculoskelet Disord 22(1):755\nBorner C, Urban G, Beaulieu LD, Sollmann N, Krieg SM, Straube A, Renner T, Schandelmaier P, Lang M, Lechner M et al (2021) The bottom-up approach: Non-invasive peripheral neurostimulation methods to treat migraine: A scoping review from the child neurologist’s perspective. Eur J Paediatr Neurol 32:16–28\nBecker WJ (2020) Botulinum Toxin in the Treatment of Headache. Toxins (Basel) 12(12):803\nBurstein R, Blumenfeld AM, Silberstein SD, Manack Adams A, Brin MF (2020) Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review. Headache 60(7):1259–1272",{"EN":157},"Tension-type headache (TTH) is the most prevalent primary headache disorder. Neck pain is commonly associated with primary headaches and the trigemino-cervical complex (TCC) refers to the convergence of trigeminal and cervical afferents onto neurons of the brainstem, thus conceptualizes the emergence of headache in relation to neck pain. However, no objective biomarkers exist for the myofascial involvement in primary headaches. This study aimed to investigate the involvement of the trapezius muscles in primary headache disorders by quantitative magnetic resonance imaging (MRI), and to explore associations between muscle T2 values and headache frequency and neck pain. This cohort study prospectively enrolled fifty participants (41 females, age range 20–31 years): 16 subjects with TTH only (TTH-), 12 with mixed-type TTH plus migraine (TTH+), and 22 healthy controls (HC). The participants completed fat-suppressed T2‐prepared three-dimensional turbo spin-echo MRI, a headache diary (over 30 days prior to MRI), manual palpation (two weeks before MRI), and evaluation of neck pain (on the day of MRI). The bilateral trapezius muscles were manually segmented, followed by muscle T2 extraction. Associations between muscle T2 and the presence of neck pain as well as the number of days with headache (considering the 30 days prior to imaging using the headache calendar) were analyzed using regression models (adjusting for age, sex, and body mass index). The TTH+ group demonstrated the highest muscle T2 values (right side: 31.4 ± 1.2 ms, left side: 31.4 ± 0.8 ms) as compared to the TTH- group or HC group (p \u003C 0.001). Muscle T2 was significantly associated with the number of headache days (β-coefficient: 2.04, p = 0.04) and the presence of neck pain (odds ratio: 2.26, p = 0.04). With muscle T2 as the predictor, the area under the curve for differentiating between HC and the TTH+ group was 0.82. Increased T2 of trapezius muscles may represent an objective imaging biomarker for myofascial involvement in primary headache disorders, which could help to improve patient phenotyping and therapy evaluation. Pathophysiologically, the increased muscle T2 values could be interpreted as a surrogate of neurogenic inflammation and peripheral sensitization within myofascial tissues.",{"EN":159},"Headache frequency and neck pain are associated with trapezius muscle T2 in tension-type headache among young adults",{"VOID":161},"10.1186\u002Fs10194-023-01626-w","PUBLICATION","VERIFIED","Auto 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Germany",{},{"id":184,"sortIndex":185,"affiliation":186,"properties":193},"1001faf7-2afb-4f7c-8c20-d3995342c9e0",1,{"id":187,"createTime":188,"updateTime":188,"relativeEntities":189,"slug":22,"properties":190,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"4a066a50-c215-428f-9d4b-7bd47b987122","2023-12-19T10:52:37.676+00:00",[],{"title":191},{"VI":192},"TUM-Neuroimaging Center, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany",{},{"id":195,"sortIndex":196,"affiliation":197,"properties":204},"884ca4d7-f083-42a8-90da-37cf07b32fb8",3,{"id":198,"createTime":199,"updateTime":199,"relativeEntities":200,"slug":22,"properties":201,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"2ad6cd38-4446-46a0-8595-c9af088a84df","2024-01-01T08:07:12.106+00:00",[],{"title":202},{"VI":203},"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA",{},{"id":22,"sortIndex":23,"affiliation":206,"properties":22},{"id":207,"createTime":208,"updateTime":208,"relativeEntities":209,"slug":22,"properties":210,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"a3c3b647-00f8-4592-a49c-03e9fffce36b","2023-12-22T03:48:31.949+00:00",[],{"title":211},{"VI":212},"Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany",{"title":214},{"VI":215},"Nico Sollmann",{"id":217,"sortIndex":218,"researcher":22,"roles":219,"affiliations":220,"properties":239},"148e5eb8-d68e-4d8a-9e37-f9d76bd10be2",10,[170],[221,229],{"id":22,"sortIndex":23,"affiliation":222,"properties":22},{"id":223,"createTime":224,"updateTime":224,"relativeEntities":225,"slug":22,"properties":226,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"24aec908-b941-42bd-9f03-ca0b23eebec6","2024-01-20T09:36:38.588+00:00",[],{"title":227},{"VI":228},"Department of Pediatrics – Dr. von Hauner Children’s Hospital, Division of Pediatric Neurology and Developmental Medicine, LMU Hospital, Ludwig-Maximilians-Universität München, Munich, 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A, Rasmussen B, Jørgensen T, Jensen R (2005) Incidence of primary headache: a Danish epidemiologic follow-up study. Am J Epidemiol 161(11):1066–1073\nLeonardi M, Raggi A (2013) Burden of migraine: international perspectives. Neurol Sci 34(1):117–118\nMateen F, Dua T, Steiner T, Saxena S (2008) Headache disorders in developing countries: research over the past decade. Cephalalgia 28(11):1107–1114\nDent W, Stelzhammer B, Meindl M, Matuja WB, Schmutzhard E, Winkler AS (2011) Migraine attack frequency, duration, and pain intensity: disease burden derived from a community‐based survey in northern Tanzania. Headache 51(10):1483–1492\nGelaye B, Peterlin BL, Lemma S, Tesfaye M, Berhane Y, Williams MA (2013) Migraine and psychiatric comorbidities among Sub‐Saharan African adults. Headache 53(2):310–321\nHouinato D, Adoukonou T, Ntsiba F, Adjien C, Avode DG, Preux PM (2009) Prevalence of migraine in a rural community in South Benin. Cephalalgia 30(1):62–67\nMengistu G, Alemayehu S (2013) Prevalence and burden of primary headache disorders among a local community in Addis Ababa. Ethiopia J Headache Pain 14(1):1–8\nOfovwe GE, Ofili AN (2010) Prevalence and impact of headache and migraine among secondary school students in Nigeria. Headache 50(10):1570–1575\nOjini F, Okubadejo N, Danesi M (2009) Prevalence and clinical characteristics of headache in medical students of the University of Lagos. Nigeria Cephalalgia 29(4):472–477\nWahab KW, Ugheoke AJ (2009) Migraine: prevalence and associated disability among Nigerian undergraduates. Can J Neurol Sci 36(2):216–221\nWinkler A, Dent W, Stelzhammer B, Kerschbaumsteiner K, Meindl M, Kaaya J, Matuja W, Schmutzhard E (2009) Prevalence of migraine headache in a rural area of northern Tanzania: a community‐based door‐to‐door survey. Cephalalgia 30(5):582–592\nAdoukonou T, Houinato D, Kankouan J, Makoutode M, Paraiso M, Tehindrazanarivelo A, Viader F, Preux PM (2009) Migraine among university students in Cotonou (Benin). Headache 49(6):887–893\nSteptoe A, Peacey V, Wardle J (2006) Sleep duration and health in young adults. Arch Intern Med 166(16):1689–1692\nStranges S, Tigbe W, Gomez-Olive FX, Thorogood M, Kandala NB (2012) Sleep problems: an emerging global epidemic? Findings from the INDEPTH WHO-SAGE study among more than 40,000 older adults from 8 countries across Africa and Asia. Sleep 35(8):1173–1181\nAdewole OO, Hakeem A, Fola A, Anteyi E, Ajuwon Z, Erhabor G (2009) Obstructive sleep apnea among adults in Nigeria. J Natl Med Assoc 101(7):720–725\nLasisi AO, Gureje O (2011) Prevalence of insomnia and impact on quality of life among community elderly with tinnitus. Ann Otol Rhinol Laryngol 120(4):226\nBigal ME, Lipton RB (2006) Modifiable risk factors for migraine progression. Headache 46(9):1334–1343\nKelman L, Rains JC (2005) Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs. Headache 45(7):904–910\nBotros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK (2009) Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med 122(12):1122–1127\nBreslau N, Roth T, Rosenthal L, Andreski P (1996) Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry 39(6):411–418\nGangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Pickering TG, Rundle AG, Zammit GK, Malaspina D (2006) Short sleep duration as a risk factor for hypertension analyses of the first national health and nutrition examination survey. Hypertension 47(5):833–839\nMarshall N, Wong K, Cullen S, Knuiman M, Grunstein R (2013) Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the busselton health study cohort. J Clin Sleep Med 10(4):355–362\nOhayon MM, Vecchierini M-F (2002) Daytime sleepiness and cognitive impairment in the elderly population. Arch Intern Med 162(2):201–208\nPeppard PE, Young T, Palta M, Skatrud J (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342(19):1378–1384\nWeaver TE (2001) Outcome measurement in sleep medicine practice and research. Part 1: assessment of symptoms, subjective and objective daytime sleepiness, health-related quality of life and functional status. Sleep Med Rev 5(2):103–128\nOdegard SS, Engstrom M, Sand T, Stovner LJ, Zwart JA, Hagen K (2010) Associations between sleep disturbance and primary headaches: the third Nord-Trondelag Health Study. J Headache Pain 11(3):197–206\nWilkinson M, Williams K, Leyton M (1977) Observations on the treatment of an acute attack of migraine. Res Clin Stud Headache 6:141–146\nAyzenberg I, Katsarava Z, Sborowski A, Chernysh M, Osipova V, Tabeeva G, Steiner T (2014) Headache‐attributed burden and its impact on productivity and quality of life in Russia: structured healthcare for headache is urgently needed. Eur J Neurol 21(5):758–765\nSharma K, Remanan R, Singh S (2013) Quality of life and psychiatric co-morbidity in Indian migraine patients: A headache clinic sample. Neurol India 61(4):355\nSkevington SM, Lotfy M, O’Connell KA (2004) The World Health Organization’s WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group. Qual Life Res 13(2):299–310\nLipton R, Liberman J, Kolodner K, Bigal M, Dowson A, Stewart W (2003) Migraine headache disability and health‐related quality‐of‐life: a population‐based case‐control study from England. Cephalalgia 23(6):441–450\nSamaan Z, Macgregor EA, Andrew D, McGuffin P, Farmer A (2010) Diagnosing migraine in research and clinical settings: the validation of the Structured Migraine Interview (SMI). BMC Neurol 10:7\nHenry P, Michel P, Brochet B, Dartigues JF, Tison S, Salamon R (1992) A nationwide survey of migraine in France: prevalence and clinical features in adults. GRIM Cephalalgia 12(4):229–237\nSociety HCSotIH (2004) The international classification of headache disorders. Cephalalgia 24:9\nBuysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193–213\nSaxena S, Carlson D, Billington R, Orley J (2001) The WHO quality of life assessment instrument (WHOQOL-Bref): the importance of its items for cross-cultural research. Qual Life Res 10(8):711–721\nBelew M, Kebede D, Kassaye M, Enquoselassie F (2000) The magnitude of khat use and its association with health, nutrition and socio-economic status. Ethiop Med J 38(1):11–26\nKalix P (1987) Khat: scientific knowledge and policy issues. Br J Addict 82(1):47–53\nWorld Health Organization (2004) Global status report on alcohol. WHO, Department of Mental Health and Substance Abuse, Geneva\nWHO (2008) STEPs manual. World Health Organization, Geneva\nCott CA, Gignac MA, Badley EM (1999) Determinants of self rated health for Canadians with chronic disease and disability. J Epidemiol Community Health 53(11):731–736\nStewart W, Wood C, Reed M, Roy J, Lipton R (2008) Cumulative lifetime migraine incidence in women and men. Cephalalgia 28(11):1170–1178\nNuhu FT, Yusuf AJ, Adeyemi SO, Kalu AO (2013) Sleep quality among primary care attendees in Kaduna, northern Nigeria: A case–control study. Int J Psychiatry Med 46(3):291–301\nZhu Z, Fan X, Li X, Tan G, Chen L, Zhou J (2013) Prevalence and predictive factors for poor sleep quality among migraineurs in a tertiary hospital headache clinic. Acta Neurol Belg 113(3):229–235\nHoefelmann LP, Lopes AS, Silva KS, Silva SG, Cabral LGA, Nahas MV (2012) Lifestyle, self-reported morbidities, and poor sleep quality among Brazilian workers. Sleep Med 13(9):1198–1201\nMinowa M, Tango T (2003) Impact and correlates of poor sleep quality in Japanese white-collar employees. Sleep 26(4):467–471\nFerrie JE, Kumari M, Salo P, Singh-Manoux A, Kivimäki M (2011) Sleep epidemiology—a rapidly growing field. Int J Epidemiol 40(6):1431–1437\nFehnel S, Zografos L, Curtice T, Shah H, McLeod L (2008) The burden of restless legs syndrome: an assessment of work productivity, sleep, psychological distress, and health status among diagnosed and undiagnosed individuals in an internet-based panel. Patient 1(3):201–210\nAraghi MH, Jagielski A, Neira I, Brown A, Higgs S, Thomas GN, Taheri S (2013) The complex associations among sleep quality, anxiety-depression, and quality of life in patients with extreme obesity. Sleep 36(12):1859\nScharf SM, Maimon N, Simon-Tuval T, Bernhard-Scharf BJ, Reuveni H, Tarasiuk A (2011) Sleep quality predicts quality of life in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 6:1\nHayashino Y, Yamazaki S, Takegami M, Nakayama T, Sokejima S, Fukuhara S (2010) Association between number of comorbid conditions, depression, and sleep quality using the Pittsburgh Sleep Quality Index: results from a population-based survey. Sleep Med 11(4):366–371\nScott D, Paterson JL, Happell B (2014) Poor sleep quality in Australian adults with comorbid psychological distress and physical illness. Behav Sleep Med 12(4):331–341\nSeidel S, Hartl T, Weber M, Matterey S, Paul A, Riederer F, Gharabaghi M, Wöber‐Bingöl Ç, Wöber C (2009) Quality of sleep, fatigue and daytime sleepiness in migraine—a controlled study. Cephalalgia 29(6):662–669\nWalters AB, Hamer JD, Smitherman TA (2014) Sleep disturbance and affective comorbidity among episodic migraineurs. Headache 54(1):116–124\nKarthik N, Kulkarni G, Taly A, Rao S, Sinha S (2012) Sleep disturbances in ‘migraine without aura’—A questionnaire based study. J Neurol Sci 321(1):73–76\nSadeghniiat K, Rajabzadeh A, Ghajarzadeh M, Ghafarpour M (2013) Sleep quality and depression among patients with migraine. Acta Med Iran 51(11):784–788\nArslantas D, Tozun M, Unsal A, Ozbek Z (2012) Headache and its effects on health-related quality of life among adults. Turk Neurosurg 23(4):498–504\nFox AW, Davis RL (1998) Migraine chronobiology. Headache 38(6):436–441\nEngstrøm M, Hagen K, Bjørk M, Stovner L, Sand T (2014) Sleep quality and arousal in migraine and tension‐type headache: the headache‐sleep study. Acta Neurol Scand 129(s198):47–54\nBrennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptáček LJ (2013) Casein kinase idelta mutations in familial migraine and advanced sleep phase. Sci Transl Med 5(183):183ra156, 181–111\nCharles A (2013) The evolution of a migraine attack - a review of recent evidence. Headache 53(2):413–419\nAloba OO, Adewuya AO, Ola BA, Mapayi BM (2007) Validity of the Pittsburgh Sleep Quality Index (PSQI) among Nigerian university students. Sleep Med 8(3):266–270\nBeaudreau SA, Spira AP, Stewart A, Kezirian EJ, Lui LY, Ensrud K, Redline S, Ancoli-Israel S, Stone KL, Study of Osteoporotic F (2012) Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women. Sleep Med 13(1):36–42",{"EN":715},"Although in the past decade occidental countries have increasingly recognized the personal and societal burden of migraine, it remains poorly understood in Africa. No study has evaluated the impact of sleep disturbances and the quality of life (QOL) in sub-Saharan Africans with migraine. This was a cross-sectional study evaluating adults, ≥ 18 years of age, attending outpatient clinics in Ethiopia. Standardized questionnaires were utilized to collect demographic, headache, sleep, lifestyle, and QOL characteristics in all participants. Migraine classification was based on International Classification of Headache Disorders (ICHD)-II criteria. The Pittsburgh Sleep Quality Index (PSQI) and the World Health Organization Quality of Life (WHOQOL-BREF) questionnaires were utilized to assess sleep quality and QOL characteristics, respectively. Multivariable logistic regression models were fit to estimate adjusted odds ratio (OR) and 95% confidence intervals (95% CI). Of 1,060 participants, 145 (14%) met ICHD-II criteria for migraine. Approximately three-fifth of the study participants (60.5%) were found to have poor sleep quality. After adjustments, migraineurs had over a two-fold increased odds (OR = 2.24, 95% CI 1.49-3.38) of overall poor sleep quality (PSQI global score >5) as compared with non-migraineurs. Compared with non-migraineurs, migraineurs were also more likely to experience short sleep duration (≤7 hours) (OR = 2.07, 95% CI 1.43-3.00), long sleep latency (≥30 min) (OR = 1.97, 95% CI 1.36-2.85), daytime dysfunction due to sleepiness (OR = 1.51, 95% CI 1.12-2.02), and poor sleep efficiency (\u003C85%) (OR = 1.93, 95% CI 1.31-2.88). Similar to occidental countries, Ethiopian migraineurs reported a reduced QOL as compared to non-migraineurs. Specifically Ethiopian migraineurs were more likely to experience poor physical (OR = 1.56, 95% CI 1.08-2.25) and psychological health (OR = 1.75, 95% CI 1.20-2.56), as well as poor social relationships (OR = 1.56, 95% CI 1.08-2.25), and living environments (OR = 1.41, 95% CI 0.97-2.05) as compared to those without migraine. Similar to occidental countries, migraine is highly prevalent among Ethiopians and is associated with poor sleep quality and a lower QOL. These findings support the need for physicians and policy makers to take action to improve the quality of headache care and access to treatment in Ethiopia.",{"EN":717},"Sleep disturbances and quality of life in Sub-Saharan African migraineurs",{"VOID":719},"10.1186\u002Fs10194-015-0504-x","https:\u002F\u002Fthejournalofheadacheandpain.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs10194-015-0504-x",[722,747,764,776,788,805,817,829],{"id":723,"sortIndex":293,"researcher":22,"roles":724,"affiliations":725,"properties":744},"3b28bf41-5ad4-4b0f-b32b-837eb04d6d9e",[170],[726,734],{"id":22,"sortIndex":23,"affiliation":727,"properties":22},{"id":728,"createTime":729,"updateTime":729,"relativeEntities":730,"slug":22,"properties":731,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"7650b248-22a2-409b-b11f-4537b63521cf","2024-02-22T00:09:08.562+00:00",[],{"title":732},{"VI":733},"Department of Epidemiology, Harvard T.H. Chan School of Public Health Multidisciplinary International Research Training Program, Boston, USA",{"id":735,"sortIndex":185,"affiliation":736,"properties":743},"19bb25d5-c1fb-4ed6-936f-e6851f70f161",{"id":737,"createTime":738,"updateTime":738,"relativeEntities":739,"slug":22,"properties":740,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"7dc062b5-d356-4cbc-a3da-8d43d41f756b","2024-02-22T00:09:08.593+00:00",[],{"title":741},{"VI":742},"Department of Mathematics & Statistics, Georgetown University, Washington, USA",{},{"title":745},{"VI":746},"Mahlet G 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Pain 76:189–199. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0304-3959(98)00041-4\nFarquhar-Smith WP, Rice ASC (2001) Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated with Inflammation of the Urinary Bladder. Anesthesiology 94:507–513. https:\u002F\u002Fdoi.org\u002F10.1097\u002F00000542-200103000-00023\nMatsuda LA, Lolait SJ, Brownstein MJ et al (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561–564. https:\u002F\u002Fdoi.org\u002F10.1038\u002F346561a0\nMunro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61–65. https:\u002F\u002Fdoi.org\u002F10.1038\u002F365061a0\nMechoulam R, Ben-Shabat S, Hanus L et al (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50:83–90. https:\u002F\u002Fdoi.org\u002F10.1016\u002F0006-2952(95)00109-d\nStarowicz K, Makuch W, Osikowicz M et al (2012) Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. Neuropharmacology 62:1746–1755. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.neuropharm.2011.11.021\nLeimuranta P, Khiroug L, Giniatullin R (2018) Emerging role of (endo)cannabinoids in migraine. Front Pharmacol 9:1–7. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphar.2018.00420\nTassorelli C, Greco R, Silberstein SD (2019) The endocannabinoid system in migraine: from bench to pharmacy and back. Curr Opin Neurol 32:405–412. https:\u002F\u002Fdoi.org\u002F10.1097\u002FWCO.0000000000000688\nAaltonen N, Savinainen JR, Ribas CR et al (2013) Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase. 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Brain 141:1040–1048. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fbrain\u002Fawy005\nEren-Koçak E, Dalkara T (2021) Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression . Front Pharmacol 12:777607. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphar.2021.777607\nZhao J, Levy D (2018) The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization. PAIN Reports 3:e632. https:\u002F\u002Fdoi.org\u002F10.1097\u002FPR9.0000000000000632\nLevy D, Labastida-Ramirez A, MaassenVanDenBrink A (2019) Current understanding of meningeal and cerebral vascular function underlying migraine headache. Cephalalgia 39:1606–1622. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0333102418771350\nNavia-Paldanius D, Patel JZ, López Navarro M et al (2016) Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α\u002Fβ-hydrolase domain containing 11 (ABHD11). Eur J Pharm Sci 93:253–263. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ejps.2016.08.031\nNavia-Paldanius D, Savinainen JR, Laitinen JT (2012) Biochemical and pharmacological characterization of human α\u002Fβ-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J Lipid Res 53:2413–2424. https:\u002F\u002Fdoi.org\u002F10.1194\u002Fjlr.M030411\nLehtonen M, Storvik M, Malinen H et al (2011) Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry. J Chromatogr B 879:677–694. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jchromb.2011.02.004\nZakharov A, Vitale C, Kilinc E et al (2015) Hunting for origins of migraine pain : cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers. Front Cell Neurosci 9:1–14. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffncel.2015.00287\nDe Col R, Messlinger K, Carr RW (2012) Repetitive activity slows axonal conduction velocity and concomitantly increases mechanical activation threshold in single axons of the rat cranial dura. J Physiol 590:725–736. https:\u002F\u002Fdoi.org\u002F10.1113\u002Fjphysiol.2011.220624\nGafurov O, Zakharov A, Koroleva K, Giniatullin R (2017) Improvement of Nociceptive Spike Clusterization with Shape Approximation. Bionanoscience 7:565–569. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12668-017-0428-9\nZakharov A, Koroleva K, Giniatullin R (2016) Clustering Analysis for Sorting ATP-Induced Nociceptive Firing in rat Meninges. Bionanoscience 6:508–512. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12668-016-0276-z\nKadir SN, Goodman DFM, Harris KD (2014) High-Dimensional Cluster Analysis with the Masked EM Algorithm. Neural Comput 26:2379–2394. https:\u002F\u002Fdoi.org\u002F10.1162\u002FNECO_a_00661\nSavinainen JR, Saario SM, Laitinen JT (2012) The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors. Acta Physiol 204:267–276. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1748-1716.2011.02280.x\nCruz SL, Sánchez-Miranda E, Castillo-Arellano JI et al (2018) Anandamide inhibits FcεRI-dependent degranulation and cytokine synthesis in mast cells through CB2 and GPR55 receptor activation. Possible involvement of CB2-GPR55 heteromers. Int Immunopharmacol 64:298–307. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.intimp.2018.09.006\nLutz B, Marsicano G, Maldonado R, Hillard CJ (2015) The endocannabinoid system in guarding against fear, anxiety and stress. Nat Rev Neurosci 16:705–718. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnrn4036\nCabral GA, Marciano-Cabral F (2005) Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. J Leukoc Biol 78:1192–1197\nGhosh S, Kinsey SG, Liu Q-S et al (2015) Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice. J Pharmacol Exp Ther 354:111–120. https:\u002F\u002Fdoi.org\u002F10.1124\u002Fjpet.115.222851\nKilinc E, Ankarali S, Torun IE, Dagistan Y (2022) Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine. Eur J Neurosci 55:1015–1031. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fejn.14897\nKoroleva K, Gafurov O, Guselnikova V, et al (2019) Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain. Front Cell Neurosci 13:. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffncel.2019.00195\nGreco R, Demartini C, Zanaboni A, et al (2021) Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine. Neurobiol Dis 147:105157. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.nbd.2020.105157\nGreco R, Bandiera T, Mangione A, et al (2015) Effects of peripheral FAAH blockade on NTG-induced hyperalgesia—evaluation of URB937 in an animal model of migraine. Cephalalgia 35:1065–1076. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0333102414566862\nChang L, Luo L, Palmer JA et al (2006) Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms. Br J Pharmacol 148:102–113. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsj.bjp.0706699\nDella Pietra A, Savinainen J, Giniatullin R (2022) Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain. Int J Mol Sci 23:4407. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fijms23084407\nPiomelli D, Tagne AM (2022) Endocannabinoid-Based Therapies. Annu Rev Pharmacol Toxicol 62:. https:\u002F\u002Fdoi.org\u002F10.1146\u002Fannurev-pharmtox-052220-021800\nAdamson Barnes NS, Mitchell VA, Kazantzis NP, Vaughan CW (2016) Actions of the dual FAAH\u002FMAGL inhibitor JZL195 in a murine neuropathic pain model. Br J Pharmacol 173:77–87. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fbph.13337\nGreco R, Demartini C, Francavilla M et al (2021) Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine. Cells 10:2543. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fcells10102543\nPapa A, Pasquini S, Contri C et al (2022) Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition. Cells 11:471. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fcells11030471\nLong JZ, Nomura DK, Vann RE et al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci 106:20270–20275. https:\u002F\u002Fdoi.org\u002F10.1073\u002Fpnas.0909411106\nFischer MJM, Reeh PW (2007) Sensitization to heat through G-protein-coupled receptor pathways in the isolated sciatic mouse nerve. Eur J Neurosci 25:3570–3575. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1460-9568.2007.05582.x\nBernardini N, Neuhuber W, Reeh P, Sauer S (2004) Morphological evidence for functional capsaicin receptor expression and calcitonin gene-related peptide exocytosis in isolated peripheral nerve axons of the mouse. Neuroscience 126:585–590. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.neuroscience.2004.03.017\nGafurov O, Koroleva K, Giniatullin R (2021) Antidromic Spike Propagation and Dissimilar Expression of P2X, 5-HT, and TRPV1 Channels in Peripheral vs. Central Sensory Axons in Meninges. Front Cell Neurosci 14:. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffncel.2020.623134\nEdvinsson JCA, Warfvinge K, Krause DN et al (2019) C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system. J Headache Pain 20:105. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs10194-019-1055-3\nIversen L (2002) Cannabinoids: a real prospect for pain relief. Curr Opin Pharmacol 2:50–55. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1471-4892(01)00120-5\nPertwee RG (2006) The pharmacology of cannabinoid receptors and their ligands: An overview. Int J Obes 30:S13–S18. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsj.ijo.0803272\nDux M, Deák É, Tassi N et al (2016) Endovanilloids are potential activators of the trigeminovascular nocisensor complex. J Headache Pain 17:53. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs10194-016-0644-7\nAkerman S, Kaube H, Goadsby PJ (2004) Anandamide Is Able to Inhibit Trigeminal Neurons Using an in Vivo Model of Trigeminovascular-Mediated Nociception. J Pharmacol Exp Ther 309:56–63. https:\u002F\u002Fdoi.org\u002F10.1124\u002Fjpet.103.059808\nMuller C, Lynch DL, Hurst DP, Reggio PH (2020) A Closer Look at Anandamide Interaction With TRPV1. Front Mol Biosci 7:. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmolb.2020.00144",{"EN":1175},"Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a promising approach to ameliorate migraine pain. However, the activity of MAGL and FAAH and action of endoCB on spiking activity of meningeal afferents, from which migraine pain originates, has not been explored thus far. Therefore, we here explored the analgesic effects of endoCB enhancement in rat and human meningeal tissues. Both MAGL and FAAH activity and local 2-AG and AEA levels were measured by activity-based protein profiling (ABPP) and LC–MS\u002FMS, respectively, in rat meninges obtained from hemiskulls of P38-P40 Wistar rats and human meninges from elderly patients undergoing non-migraine related neurosurgery. The action on endoCBs upon administration of novel dual MAGL\u002FFAAH inhibitor AKU-005 on meningeal afferents excitability was tested by investigating paired KCl-induced spiking and validation with local (co-)application of either AEA or 2-AG. Finally, the specific TRPV1 agonist capsaicin and blocker capsazepine were tested. The basal level of 2-AG exceeded that of AEA in rat and human meninges. KCl-induced depolarization doubled the level of AEA. AKU-005 slightly increased spontaneous spiking activity whereas the dual MAGL\u002FFAAH inhibitor significantly decreased excitation of nerve fibres induced by KCl. Similar inhibitory effects on meningeal afferents were observed with local applications of 2-AG or AEA. The action of AKU-005 was reversed by CB1 antagonist AM-251, implying CB1 receptor involvement in the anti-nociceptive effect. The inhibitory action of AEA was also reversed by AM-251, but not with the TRPV1 antagonist capsazepine. Data cluster analysis revealed that both AKU-005 and AEA largely increased long-term depression-like meningeal spiking activity upon paired KCl-induced spiking. In the meninges, high anti-nociceptive 2-AG levels can tonically counteract meningeal signalling, whereas AEA can be engaged on demand by local depolarization. AEA-mediated anti-nociceptive effects through CB1 receptors have therapeutic potential. Together with previously detected MAGL activity in trigeminal ganglia, dual MAGL\u002FFAAH inhibitor AKU-005 appears promising as migraine treatment. \n                  \n                    \n                      \n                    \n                  \n                ",{"EN":1177},"Potent dual MAGL\u002FFAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain",{"VOID":1179},"10.1186\u002Fs10194-023-01568-3","https:\u002F\u002Fthejournalofheadacheandpain.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs10194-023-01568-3",[1182,1199,1211,1226,1255,1274,1291,1303,1320,1332],{"id":1183,"sortIndex":196,"researcher":22,"roles":1184,"affiliations":1185,"properties":1196},"ae8fba26-ab31-4c02-86bc-5e6cb331ce73",[170],[1186],{"id":22,"sortIndex":23,"affiliation":1187,"properties":22},{"id":1188,"createTime":1189,"updateTime":1190,"relativeEntities":1191,"slug":1192,"properties":1193,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"09f4dc62-b01d-4a8f-a39f-129046c38771","2023-12-28T06:14:42.104+00:00","2025-06-11T22:53:03.988+00:00",[],"A-I-Virtanen-Institute-for-Molecular-Sciences-University-of-Eastern-Finland-Kuopio-Finland",{"title":1194},{"VI":1195},"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland",{"title":1197},{"VI":1198},"Raisa Giniatullina",{"id":1200,"sortIndex":23,"researcher":22,"roles":1201,"affiliations":1202,"properties":1208},"6d6769d7-9fcc-4a9f-94c8-c824881bd10c",[170],[1203],{"id":22,"sortIndex":23,"affiliation":1204,"properties":22},{"id":1188,"createTime":1189,"updateTime":1190,"relativeEntities":1205,"slug":1192,"properties":1206,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1207},{"VI":1195},{"title":1209},{"VI":1210},"Adriana Della Pietra",{"id":1212,"sortIndex":306,"researcher":22,"roles":1213,"affiliations":1214,"properties":1223},"479c712e-9b0d-423d-905d-738399669731",[170],[1215],{"id":22,"sortIndex":23,"affiliation":1216,"properties":22},{"id":1217,"createTime":1218,"updateTime":1218,"relativeEntities":1219,"slug":22,"properties":1220,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"9bf49c2f-7422-4271-b1c8-b127bc290487","2024-01-16T03:47:27.762+00:00",[],{"title":1221},{"VI":1222},"Department of Neurosurgery, Kuopio University Hospital and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland",{"title":1224},{"VI":1225},"Ville Leinonen",{"id":1227,"sortIndex":434,"researcher":22,"roles":1228,"affiliations":1229,"properties":1252},"abdf4033-60bf-496a-96fa-8e645fa8a8cb",[170],[1230,1240],{"id":22,"sortIndex":23,"affiliation":1231,"properties":22},{"id":1232,"createTime":1233,"updateTime":1234,"relativeEntities":1235,"slug":1236,"properties":1237,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"18c6773a-3871-4383-9a7e-06e92181b1a5","2023-12-06T10:48:51.186+00:00","2025-02-08T04:38:13.840+00:00",[],"Department-of-Human-Genetics-Leiden-University-Medical-Center-Leiden-The-Netherlands",{"title":1238},{"VI":1239},"Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands",{"id":1241,"sortIndex":185,"affiliation":1242,"properties":1251},"2f688b99-1ee9-4423-999d-5f0e70f122f6",{"id":1243,"createTime":1244,"updateTime":1245,"relativeEntities":1246,"slug":1247,"properties":1248,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"72e299d1-a176-4535-8e22-9de0dea70370","2024-04-07T02:57:34.243+00:00","2025-01-25T21:05:55.775+00:00",[],"Department-of-Neurology-Leiden-University-Medical-Center-Leiden-The-Netherlands",{"title":1249},{"VI":1250},"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands",{},{"title":1253},{"VI":1254},"Arn M. J. M. van den Maagdenberg",{"id":1256,"sortIndex":185,"researcher":22,"roles":1257,"affiliations":1258,"properties":1271},"26eaf226-84b8-4501-8103-04291d64ff73",[170],[1259,1266],{"id":1260,"sortIndex":185,"affiliation":1261,"properties":1265},"211d6d21-fb1f-44f1-9478-0890e2104f2d",{"id":1232,"createTime":1233,"updateTime":1234,"relativeEntities":1262,"slug":1236,"properties":1263,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1264},{"VI":1239},{},{"id":22,"sortIndex":23,"affiliation":1267,"properties":22},{"id":1188,"createTime":1189,"updateTime":1190,"relativeEntities":1268,"slug":1192,"properties":1269,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1270},{"VI":1195},{"title":1272},{"VI":1273},"Georgii Krivoshein",{"id":1275,"sortIndex":402,"researcher":22,"roles":1276,"affiliations":1277,"properties":1288},"32ead760-9cf2-4c24-8058-442560ea4038",[170],[1278],{"id":22,"sortIndex":23,"affiliation":1279,"properties":22},{"id":1280,"createTime":1281,"updateTime":1282,"relativeEntities":1283,"slug":1284,"properties":1285,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"72cb8593-20fe-4b6d-83b8-b7681a2eec41","2023-12-05T06:17:22.407+00:00","2024-10-16T22:21:38.540+00:00",[],"Institute-of-Biomedicine-University-of-Eastern-Finland-Kuopio-Finland",{"title":1286},{"VI":1287},"Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland",{"title":1289},{"VI":1290},"Juha Savinainen",{"id":1292,"sortIndex":174,"researcher":22,"roles":1293,"affiliations":1294,"properties":1300},"3b352764-e9f4-40cd-9a57-9e5596cdb373",[170],[1295],{"id":22,"sortIndex":23,"affiliation":1296,"properties":22},{"id":1280,"createTime":1281,"updateTime":1282,"relativeEntities":1297,"slug":1284,"properties":1298,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1299},{"VI":1287},{"title":1301},{"VI":1302},"Konstantin Ivanov",{"id":1304,"sortIndex":260,"researcher":22,"roles":1305,"affiliations":1306,"properties":1317},"00e77d39-14dc-4bf9-9dca-c99bafa218fe",[170],[1307],{"id":22,"sortIndex":23,"affiliation":1308,"properties":22},{"id":1309,"createTime":1310,"updateTime":1311,"relativeEntities":1312,"slug":1313,"properties":1314,"entityType":58,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"264cd1ff-ab36-4855-aa4b-340eb3e1b3af","2024-01-13T07:04:29.579+00:00","2024-12-02T08:29:06.918+00:00",[],"School-of-Pharmacy-Faculty-of-Health-Sciences-University-of-Eastern-Finland-Kuopio-Finland",{"title":1315},{"VI":1316},"School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland",{"title":1318},{"VI":1319},"Marko 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ME, Ferrari M, Silberstein SD, Lipton RB, Goadsby PJ (2009) Migraine in the triptan era: lessons from epidemiology, pathophysiology, and clinical science. 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Electroencephalogr Clin Neurophysiol 41(3):268–276, 60214, 10.1016\u002F0013-4694(76)90119-X, 1:STN:280:DyaE283ls12ksA%3D%3D\nLlinas RR, Ribary U, Jeanmonod D, Kronberg E, Mitra PP (1999) Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc Natl Acad Sci USA 96(26):15222–15227, 10611366, 10.1073\u002Fpnas.96.26.15222, 1:CAS:528:DC%2BD3cXhtFejtA%3D%3D\nTai C, Kuzmiski JB, MacVicar BA (2006) Muscarinic enhancement of R-type calcium currents in hippocampal CA1 pyramidal neurons. J Neurosci 26(23):6249–6258, 16763032, 10.1523\u002FJNEUROSCI.1009-06.2006, 1:CAS:528:DC%2BD28XmtFSlsLY%3D\nCrunelli V, Cope DW, Hughes SW (2006) Thalamic T-type Ca2+ channels and NREM sleep. Cell Calcium 40(2):175–190, 16777223, 10.1016\u002Fj.ceca.2006.04.022, 1:CAS:528:DC%2BD28XmsFSrs7s%3D\nSchmitz N, Arkink EB, Mulder M, Rubia K, Admiraal-Behloul F, Schoonman GG et al (2008) Frontal lobe structure and executive function in migraine patients. Neurosci Lett 440(2):92–96, 18556120, 10.1016\u002Fj.neulet.2008.05.033, 1:CAS:528:DC%2BD1cXnsFClt7c%3D\nThomsen LL, Oestergaard E, Bjornsson A, Stefansson H, Fasquel AC, Gulcher J et al (2008) Screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients. Cephalalgia 28(9):914–921, 18513263, 10.1111\u002Fj.1468-2982.2008.01599.x, 1:STN:280:DC%2BD1cnhsVSluw%3D%3D\nJen JC, Kim GW, Dudding KA, Baloh RW (2004) No mutations in CACNA1A and ATP1A2 in probands with common types of migraine. Arch Neurol 61(6):926–928, 15210532, 10.1001\u002Farchneur.61.6.926\nSchoenen J, Jamart B, Delwaide PJ (1987) Cartographie electroencephalographique dans les migraines en periodes critique et intercritique. Rev Electroencephalogr Neurophysiol Clin 17(3):289–299, 3685574, 10.1016\u002FS0370-4475(87)80066-7, 1:STN:280:DyaL1c%2FmvFKrsw%3D%3D\nde Tommaso M, Sciruicchio V, Guido M, Sasanelli G, Specchio LM, Puca FM (1998) EEG spectral analysis in migraine without aura attacks. 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Headache 48(7):1044–1055, 18479421, 10.1111\u002Fj.1526-4610.2008.01133.x\nWaldie KE, Hausmann M, Milne BJ, Poulton R (2002) Migraine and cognitive function: a life-course study. Neurology 59(6):904–908, 12297575\nCabeza R (2002) Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol Aging 17(1):85–100, 11931290, 10.1037\u002F0882-7974.17.1.85\nSalinsky MC, Oken BS, Storzbach D, Dodrill CB (2003) Assessment of CNS effects of antiepileptic drugs by using quantitative EEG measures. Epilepsia 44(8):1042–1050, 12887435, 10.1046\u002Fj.1528-1157.2003.60602.x, 1:CAS:528:DC%2BD3sXntVCltbs%3D\nClemens B, Menes A, Piros P, Bessenyei M, Altmann A, Jerney J et al (2006) Quantitative EEG effects of carbamazepine, oxcarbazepine, valproate, lamotrigine, and possible clinical relevance of the findings. Epilepsy Res 70(2–3):190–199, 16765028, 10.1016\u002Fj.eplepsyres.2006.05.003, 1:CAS:528:DC%2BD28XotVCksbs%3D\nPerneger TV (1998) What’s wrong with Bonferroni adjustments. BMJ 316(7139):1236–1238, 9553006, 1:STN:280:DyaK1c3itFSmtg%3D%3D\nFeise RJ (2002) Do multiple outcome measures require p value adjustment? BMC Med Res Methodol 2:8, 12069695, 10.1186\u002F1471-2288-2-8\nSchulz KF, Grimes DA (2005) Multiplicity in randomised trials I: endpoints and treatments. Lancet 365(9470):1591–1595, 15866314, 10.1016\u002FS0140-6736(05)66461-6",{"EN":1454},"Abnormal electroencephalography (EEG) in migraineurs has been reported in several studies. However, few have evaluated EEG findings in migraineurs during a time period when neither the last attack nor the next attack may interact with the results. We, therefore, compared interictal EEG in migraineurs and headache-free subjects with a design controlled for interference by pre-ictal changes. Pre-ictal EEG findings in the painful cranial side during the next attack after registration were also investigated. Correlations between clinical variables and EEG are reported as well. Interictal EEGs from 33 migraineurs (6 with and 27 without aura) and 31 controls were compared. Absolute power, asymmetry and relative power were studied for delta, theta and alpha frequency bands in parieto-occipital, temporal and fronto-central areas. EEG variables were correlated to attack frequency, headache duration, attack duration, pain intensity, photo- and phonophobia. Compared with controls, migraineurs had increased relative theta power in all cortical regions and increased delta activity in the painful fronto-central region. Absolute power and asymmetry were similar among groups. In age-adjusted analyses, headache intensity correlated with increased delta activity. In this blinded controlled study, we found globally increased relative theta activity in migraineurs. 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