[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_7bd9bf2f-e3b1-44b8-a22f-c2edb426a91c":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:7bd9bf2f-e3b1-44b8-a22f-c2edb426a91c,\"}":24},{"code":4,"data":5,"meta":17},"SUCCESS",{"id":6,"createTime":7,"updateTime":7,"relativeEntities":8,"slug":9,"properties":10,"entityType":15,"verifyStatus":16,"verifyTime":17,"verifyNote":17,"syncStatus":16,"languages":17,"translateLanguages":17,"viewCount":18,"subjectFields":19,"manageAffiliations":20,"indexDatabases":21,"url":22,"thumbnailPath":17,"statistic":17,"gsStatistic":17,"type":23,"analyzePriority":17},"7bd9bf2f-e3b1-44b8-a22f-c2edb426a91c","2025-10-14T02:05:24.843+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Y-D%C6%B0%E1%BB%A3c-h%E1%BB%8Dc-Qu%C3%A2n-s%E1%BB%B1",{"issn":11,"title":13},{"VOID":12},"18590748",{"VOID":14},"Tạp chí Y Dược học Quân sự","PUBLISHER","PENDING",null,0,[],[],[],"https:\u002F\u002Fjmpm.vn\u002Findex.php\u002Fjmpm","JOURNAL",{"meta":25,"data":27},{"total":26},"1",[28],{"id":29,"createTime":30,"updateTime":31,"relativeEntities":32,"slug":33,"properties":34,"entityType":45,"verifyStatus":46,"verifyTime":47,"verifyNote":48,"syncStatus":16,"languages":49,"translateLanguages":17,"viewCount":18,"primaryUrl":51,"fullTextUrl":52,"authors":53,"publicationType":147,"publisherRelationship":148,"citationCount":17,"citationInfo":17,"publishDate":164,"publishYear":165,"citationAnalyzeStatus":16,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":166,"isForceReanalyzing":187},"18b2e700-b000-4d63-91ff-812bb9687986","2025-07-10T05:10:26.099+00:00","2025-10-14T02:05:24.753+00:00",[],"%C4%90%E1%BA%B6C-%C4%90I%E1%BB%82M-L%C3%82M-S%C3%80NG-C%E1%BA%ACN-L%C3%82M-S%C3%80NG-V%C3%80-GI%C3%81-TR%E1%BB%8A-M%E1%BB%98T-S%E1%BB%90-TH%C3%94NG-S%E1%BB%90-VI%C3%8AM-%E1%BB%9E-B%E1%BB%86NH-NH%C3%82N-UNG-TH%C6%AF-PH%E1%BB%94I-KH%C3%94NG-T%E1%BA%BE-B%C3%80O-NH%E1%BB%8E-GIAI-%C4%90O%E1%BA%A0N-MU%E1%BB%98N",{"keywords":35,"abstract":37,"title":40,"doi":43},{"VI":36},"Ung thư phổi không tế bào nhỏ,Tỷ lệ bạch cầu trung tính trên bạch cầu lympho (NLR),Tỷ lệ tiểu cầu trên bạch cầu lympho (PLR),Chỉ số viêm - miễn dịch toàn thân (SII)",{"VI":38,"EN":39},"Mục ti&ecirc;u: M&ocirc; tả đặc điểm l&acirc;m s&agrave;ng, cận l&acirc;m s&agrave;ng v&agrave; c&aacute;c th&ocirc;ng số vi&ecirc;m (NLR, PLR v&agrave; SII) ở bệnh nh&acirc;n (BN) ung thư phổi kh&ocirc;ng tế b&agrave;o nhỏ (UTPKTBN) giai đoạn muộn. Phương ph&aacute;p nghi&ecirc;n cứu: Nghi&ecirc;n cứu hồi cứu kết hợp tiến cứu, m&ocirc; tả cắt ngang tr&ecirc;n 109 BN được chẩn đo&aacute;n x&aacute;c định UTPKTBN giai đoạn muộn (IIIB, IIIC, IV), điều trị nội tr&uacute; tại Trung t&acirc;m Nội H&ocirc; hấp, Bệnh viện Qu&acirc;n y 103 từ th&aacute;ng 01\u002F2019 - 9\u002F2024. Kết quả: Tuổi trung b&igrave;nh mắc UTPKTBN l&agrave; 65,43 &plusmn; 12,09, nam giới chiếm ưu thế. Triệu chứng l&acirc;m s&agrave;ng chủ yếu l&agrave; ho (86,33%) v&agrave; đau ngực (53,33%). C&aacute;c cơ quan thường di căn gồm m&agrave;ng phổi (42,20%), phổi đối b&ecirc;n (22,93%), ổ bụng (19,27%) v&agrave; xương (18,35%). 79,82% BN ở giai đoạn IV, trong đ&oacute; 75,23% l&agrave; ung thư biểu m&ocirc; tuyến. Tr&ecirc;n phim chụp cắt lớp vi t&iacute;nh (CLVT) ngực, tổn thương phổ biến l&agrave; b&oacute;ng mờ dạng tr&ograve;n (92\u002F109) v&agrave; tr&agrave;n dịch m&agrave;ng phổi (50\u002F109). Gi&aacute; trị trung vị của NLR l&agrave; 3,467 (khoảng từ 0,739 - 36,943), PLR v&agrave; SII lần lượt l&agrave; 166,379 v&agrave; 981,167 (khoảng từ 35,494 - 1.127,027 v&agrave; 232,214 - 14.831,676). Kết luận: BN UTPKTBN giai đoạn muộn chủ yếu l&agrave; nam giới, tuổi cao, c&oacute; triệu chứng l&acirc;m s&agrave;ng đa dạng v&agrave; thường l&agrave; ung thư biểu m&ocirc; tuyến. C&aacute;c h&igrave;nh ảnh tr&ecirc;n CLVT ngực thường gặp l&agrave; b&oacute;ng mờ tr&ograve;n v&agrave; tr&agrave;n dịch m&agrave;ng phổi. C&aacute;c chỉ số vi&ecirc;m NLR, PLR v&agrave; SII c&oacute; gi&aacute; trị trung vị lần lượt l&agrave; 3,467; 166,379 v&agrave; 981,167.","Abstract\r\nObjectives: To describe clinical and paraclinical characteristics and some inflammatory-scores (NLR, PLS, SII) in late stage non-small cell lung cancer&nbsp;&nbsp; patients at&nbsp; Military Hospital 103. Methods: A retrospective and prospective, crosssectional study on 109 inpatients diagnosed with late stage non-small cell lung cancer at the Respiratory Center, Military Hospital 103 from January 2019 to September 2024. Results: The mean age of patiens were 65.43 ± 12.09 years, with a higher proportion of males. Patients have a variety of clinical symptoms, most common subjective symptoms were cough (86.33%) and chest pain (53.33%). The most common sites of metastasis were the pleura (42.20%), contralateral lung (22.93%), abdomen (19.27%) and bones (18.35%). 79,82% of patients were in stage IV, and adenocarcinoma accounted for 75.23% of the cases. On chest CT, the most frequent findings were pleural effusion (50\u002F109) and round-shaped opacity (92\u002F109). The median value of NLR was 3.467, with a range of 0.739 to 36.943. The median values for PLR and SII were 166.379 and 981.167, respectively, with PLR ranging from 35.494 to 1127.027 and SII from 232.214 to 14831.676. Conclusion: Patients with late stage non-small cell lung cancer were higher rate in male, high mean age with diversified clinical symptoms, predominantly adenocarcinoma, and typically presents with round-shaped opacity on chest CT. The median values of NLR, PLR, and SII were 3.467, 166.379, and 981.167, respectively.",{"VI":41,"EN":42},"ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ GIÁ TRỊ MỘT SỐ THÔNG SỐ VIÊM Ở BỆNH NHÂN UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ GIAI ĐOẠN MUỘN","CLINICAL, PARACLINICAL CHARACTERISTICS AND INFLAMMATION-SCORES IN LATE STAGE NON-SMALL CELL LUNG CANCER",{"VOID":44},"10.56535\u002Fjmpm.v50i5.1217","PUBLICATION","VERIFIED","2025-07-10T05:10:26.094+00:00","Auto Verify",[50],"VI","https:\u002F\u002Fjmpm.vn\u002Findex.php\u002Fjmpm\u002Farticle\u002Fview\u002F1217","https:\u002F\u002Fjmpm.vn\u002Findex.php\u002Fjmpm\u002Farticle\u002Fdownload\u002F1217\u002F679",[54,73,87,101,115,134],{"id":55,"sortIndex":56,"researcher":17,"roles":57,"affiliations":58,"properties":70},"a1da7393-ecd1-4276-88d4-239a98514c0e",4,[],[59],{"id":60,"sortIndex":18,"affiliation":61,"properties":17},"1cf3eea3-eb31-4a9c-b8b9-e88c57d40bdc",{"id":62,"createTime":63,"updateTime":63,"relativeEntities":64,"slug":65,"properties":66,"entityType":69,"verifyStatus":16,"verifyTime":17,"verifyNote":17,"syncStatus":16,"languages":17,"translateLanguages":17,"viewCount":18},"5e4ad3d5-3c6f-4148-b4ae-a9963b7f86d8","2025-10-14T02:05:25.481+00:00",[],"B%E1%BB%99-m%C3%B4n-Trung-t%C3%A2m-N%E1%BB%99i-H%C3%B4-h%E1%BA%A5p-B%E1%BB%87nh-vi%E1%BB%87n-Qu%C3%A2n-y-103-H%E1%BB%8Dc-vi%E1%BB%87n-Qu%C3%A2n-y",{"title":67},{"EN":68},"Bộ môn - 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Latest global cancer data shows rising incidene and stark inequities. 2024.",{"id":17,"text":170,"url":17,"identifiers":17},"Riely Gregory, J Wood, et al. Non-small cell lung cancer, version 4.2024, NCCN clinical practice guidelines in oncology. J Journal of the National Comprehensive Cancer Network. 2024; 22(4):249-274.",{"id":17,"text":172,"url":17,"identifiers":17},"Coussens LM and Werb Z. Inflammation and cancer. Nature, 2002; 420(6917):860-867.",{"id":17,"text":174,"url":17,"identifiers":17},"Nguyễn Thị Lan Anh. Nghiên cứu đặc điểm đột biến gen EGFR và mối liên quan với lâm sàng, cận lâm sàng ở BN ung thư phổi biểu mô. Luận án Tiến sĩ Y học, Học viện Quân y. 2017.",{"id":17,"text":176,"url":17,"identifiers":17},"Nguyễn Đức Nhơn, Nguyễn Hồng Phong. Nghiên cứu tình hình và một số yếu tố liên quan đến đột biến gen EGFR trên BN ung thư biểu mô tuyến nguyên phát của phổi tại Bệnh viện Ung bướu thành phố Cần Thơ năm 2021. Tạp chí Y Dược học Cần Thơ. 2023; 41:120-127.",{"id":17,"text":178,"url":17,"identifiers":17},"Hoesel B and Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013; 12:86.",{"id":17,"text":180,"url":17,"identifiers":17},"O'Brien SM, Klampatsa A, Thompson JC, et al. Function of human tumor-infiltrating lymphocytes in early-stage non-small cell lung cancer. Cancer Immunol Res. 2019; 7(6):896-909.",{"id":17,"text":182,"url":17,"identifiers":17},"Shu L, Lin S, Zhou S, et al. Glycan-Lectin interactions between platelets and tumor cells drive hematogenous metastasis. Platelets. 2024; 35(1):2315037.",{"id":17,"text":184,"url":17,"identifiers":17},"Tong YS, Tan J, Zhou XL, et al. Systemic immune-inflammation index predicting chemoradiation resistance and poor outcome in patients with stage III non-small cell lung cancer. J Transl Med. 2017; 15(1):221.",{"id":17,"text":186,"url":17,"identifiers":17},"Huỳnh Đức Lê và CS. Nghiên cứu giá trị chỉ số NLR, PLR trong dự báo đáp ứng điều trị không tế bào nhỏ với phác đồ hóa chất có Platinum. Tạp chí Y học Việt Nam. 2022; 519(2):296-301.",false]