[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"\"}":3,"_public_publisher_byId_927c69a7-42e5-4fa5-998d-55f42cbf1f51":656,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"totalCitation\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:927c69a7-42e5-4fa5-998d-55f42cbf1f51,\"}":763},{"meta":4,"data":6},{"total":5},"117",[7,60,176,207,299,413,445,480,543,572],{"id":8,"createTime":9,"updateTime":10,"relativeEntities":11,"slug":12,"properties":13,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":29,"subjectFields":30,"manageAffiliations":31,"indexDatabases":32,"url":33,"thumbnailPath":34,"statistic":35,"gsStatistic":26,"type":26,"analyzePriority":26},"5a09599f-54d1-44c3-8f16-3847ac552024","2023-08-17T04:28:50.832+00:00","2025-10-13T23:58:52.517+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Truy%E1%BB%81n-nhi%E1%BB%85m-Vi%E1%BB%87t-Nam",{"country":14,"issn":16,"introduce":18,"title":21},{"VOID":15},"VN",{"VOID":17},"08667829",{"EN":19,"VI":20},"{\"ops\":[{\"insert\":\"Vietnam Journal of Infectious Diseases is a social - professional forum of the Vietnam Society for Infectious Diseases, whose responsibility is to introduce the researches, the scientific advances in Vietnam and from the world; to contribute to the improvement of knowledges for health care staffs about clinic, treatment, guideline, prevention, epidemiology for infectious diseases, HIV\u002FAIDS and community health care; to provide, exchange and publish scientific information to the public accurately and promptly.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Vietnam Journal of Infectious Diseases publishes in the whole country; serves the professional work for researchers, clinical staffs, administrators, undergraduate and postgraduate students who are working and studying in the infections, tropical diseases and HIV\u002FAIDS from central to local levels, also organizations and individuals in the world who are interested in infectious and tropical diseases and prevention for HIV\u002FAIDS.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Editor in Chief:\"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"insert\":\"Prof. Dr. Nguyen Van Kinh. - Chairman of Editorial Board\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"Prof. Dr. Nguyen Van Mui.\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Headquarter:\"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Address:\"},{\"insert\":\" Level 6, National Hospital for Tropical Diseases, No. 78 Giai Phong Street, Dong Da District, Hanoi city, Vietnam.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Tel:\"},{\"insert\":\" \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:02435765464\"},\"insert\":\"02435765464\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913552672\"},\"insert\":\"0913552672\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913228072\"},\"insert\":\"0913228072\"},{\"insert\":\".\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Email\"},{\"insert\":\": \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Findex\u002Fadmin\u002Fcontexts\u002Fmailto:tungphamvan52@gmail.com\"},\"insert\":\"tungphamvan52@gmail.com\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Fmailto:tapchitruyennhiem@gmail.com\"},\"insert\":\"tapchitruyennhiem@gmail.com\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Bank account:\"},{\"insert\":\" 0021000275119, Vietcombank Hanoi Branch. Transaction office No. 7, 402 Tran Khat Chan, Hai Ba Trung District, Hanoi city, Vietnam.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Tạp chí Truyền nhiễm Việt Nam là cơ quan ngôn luận của Hội Truyền nhiễm Việt Nam, chịu sự lãnh đạo, chỉ đạo trực tiếp của Thường vụ Ban Chấp hành Hội Truyền nhiễm Việt Nam; sự kiểm tra, giám sát về nghiệp vụ báo chí của các cơ quan chức năng quản lý báo chí thuộc Bộ Thông tin và Truyền thông và Ban Tuyên giáo Trung ương Đảng.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí có trách nhiệm giới thiệu các công trình nghiên cứu khoa học, những tiến bộ khoa học trên thế giới và trong nước, góp phần nâng cao kiến thức khoa học cho cán bộ y tế về lâm sàng, điều trị, hướng dẫn, dự phòng, dịch tễ học các bệnh truyền nhiễm, HIV\u002FAIDS và chăm sóc sức khỏe cộng đồng; cung cấp, trao đổi, phổ biến các thông tin khoa học tới công chúng chính xác và kịp thời.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí xuất bản 03 tháng\u002F01 kỳ và được phát hành qua Bưu điện và tự phát hành trong phạm vi toàn quốc.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Lãnh đạo Tạp chí: \"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"insert\":\"Tổng Biên tập: ThS.BSCKII Nguyễn Trung Cấp\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"Phó Tổng Biên tập:\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"            TS.BSCKII Phạm Ngọc Thạch\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Trụ sở tòa soạn:\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Địa chỉ: Tầng 6, Bệnh viện Bệnh Nhiệt đới Trung ương, 78 đường Giải Phóng, phường Phương Mai, quận Đống Đa, thành phố Hà Nội.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Điện thoại:\"},{\"insert\":\" \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:02435765464\"},\"insert\":\"02435765464\"},{\"insert\":\" - \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913228072\"},\"insert\":\"0913228072\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Email\"},{\"insert\":\": \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Findex\u002Fadmin\u002Fcontexts\u002Fmailto:tungphamvan52@gmail.com\"},\"insert\":\"tungphamvan52@gmail.com\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Fmailto:tapchitruyennhiem@gmail.com\"},\"insert\":\"tapchitruyennhiem@gmail.com\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Tài khoản:\"},{\"insert\":\" Số 0021000275119 Ngân hàng Ngoại thương Việt Nam, chi nhánh Hà Nội (Vietcombank Hà Nội). Phòng giao dịch số 7, 402 Trần Khát Chân, quận Hai Bà Trưng, Thành phố Hà Nội.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}",{"EN":22,"VI":23},"Vietnam Journal of Infectious Diseases","Tạp chí Truyền nhiễm Việt Nam","PUBLISHER","VERIFIED",null,"Admin update database","PENDING",51,[],[],[],"https:\u002F\u002Ftruyennhiemvietnam.vn\u002Findex.php\u002Fvjid","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F5a09599f-54d1-44c3-8f16-3847ac552024\u002Fadb0e52bf25e0de580fd4289519cb8bf.jpg",{"impactFactor":36,"impactFactorByYear":37,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":41,"totalPublicationByYear":42,"totalCitation":48,"totalCitationByYear":49,"totalCitationPerPublication":54,"totalCitationPerPublicationByYear":55,"hindexLast5Year":59,"hindex":59},0,{"2022":38,"2023":39,"2024":40},0.01,0.03,0.13,315,{"2020":43,"2021":44,"2022":45,"2023":46,"2024":47},63,58,57,65,72,43,{"2020":50,"2021":51,"2022":52,"2023":53},8,15,9,11,0.14,{"2020":40,"2021":56,"2022":57,"2023":58},0.26,0.16,0.17,3,{"id":61,"createTime":62,"updateTime":63,"relativeEntities":64,"slug":65,"properties":66,"entityType":24,"verifyStatus":25,"verifyTime":78,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":79,"subjectFields":80,"manageAffiliations":81,"indexDatabases":136,"url":137,"thumbnailPath":26,"statistic":138,"gsStatistic":155,"type":175,"analyzePriority":26},"25b6bd10-676c-40c0-8dc3-356d1679a284","2023-05-19T02:22:33.430+00:00","2026-06-18T23:33:57.141+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Y-D%C6%B0%E1%BB%A3c-h%E1%BB%8Dc-C%E1%BA%A7n-Th%C6%A1",{"country":67,"issn":68,"introduce":70,"title":73,"gsId":76},{"VOID":15},{"VOID":69},"23541210",{"EN":71,"VI":72},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"EN":74,"VI":75},"Cantho Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"VOID":77},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",32,[],[82],{"id":83,"createTime":84,"updateTime":85,"relativeEntities":86,"slug":87,"properties":88,"entityType":98,"verifyStatus":25,"verifyTime":99,"verifyNote":26,"syncStatus":28,"languages":100,"translateLanguages":26,"viewCount":103,"url":104,"parentIds":105,"statistic":106},"6413896b-eca9-442b-a73f-182a58a0ce40","2023-06-12T14:59:13.446+00:00","2026-06-19T02:29:32.871+00:00",[],"Tr%C6%B0%E1%BB%9Dng-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Y-D%C6%B0%E1%BB%A3c-C%E1%BA%A7n-Th%C6%A1",{"country":89,"title":90,"address":93,"abbreviation":96},{"VOID":15},{"EN":91,"VI":92},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"VI":94,"EN":95},"Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam","No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam",{"VOID":97},"ctump","AFFILIATION","2023-08-01T14:07:27.977+00:00",[101,102],"VI","EN",12,"http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":107,"i10Index":111,"i10IndexLast5Year":59,"totalPublication":112,"totalPublicationByYear":113,"totalCitation":122,"totalCitationByYear":123,"totalCitationPerPublication":128,"totalCitationPerPublicationByYear":129,"hindexLast5Year":135,"hindex":135},{"2022":108,"2023":109,"2024":110,"2025":38},0.1,0.05,0.07,4,1489,{"2013":114,"2014":115,"2015":115,"2016":111,"2017":115,"2018":59,"2019":114,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120,"2025":121,"2026":111},2,1,10,84,281,680,260,156,313,{"2013":59,"2014":114,"2018":124,"2021":125,"2022":126,"2023":127},17,36,123,132,0.21,{"2013":130,"2014":114,"2018":131,"2021":132,"2022":133,"2023":134},1.5,5.67,0.43,0.44,0.19,6,[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":36,"impactFactorByYear":139,"i10Index":114,"i10IndexLast5Year":114,"totalPublication":140,"totalPublicationByYear":141,"totalCitation":147,"totalCitationByYear":148,"totalCitationPerPublication":151,"totalCitationPerPublicationByYear":152,"hindexLast5Year":135,"hindex":135},{"2022":38,"2023":36,"2024":39,"2025":38},1956,{"0":114,"2019":114,"2020":50,"2021":142,"2022":143,"2023":144,"2024":145,"2025":146},76,403,789,305,371,524,{"0":114,"2019":135,"2021":124,"2022":149,"2023":150,"2024":111,"2025":114},287,206,0.27,{"0":115,"2019":59,"2021":153,"2022":154,"2023":56,"2024":38,"2025":38},0.22,0.71,{"impactFactor":26,"impactFactorByYear":26,"i10Index":114,"i10IndexLast5Year":114,"totalPublication":156,"totalPublicationByYear":157,"totalCitation":163,"totalCitationByYear":164,"totalCitationPerPublication":169,"totalCitationPerPublicationByYear":170,"hindexLast5Year":135,"hindex":135},461,{"0":158,"2019":114,"2021":159,"2022":160,"2023":161,"2024":158,"2025":162},7,37,296,107,5,419,{"2021":59,"2022":59,"2023":165,"2024":166,"2025":167,"2026":168},71,126,171,41,0.91,{"2021":171,"2022":38,"2023":172,"2024":173,"2025":174},0.08,0.66,18,34.2,"JOURNAL",{"id":177,"createTime":178,"updateTime":179,"relativeEntities":180,"slug":181,"properties":182,"entityType":24,"verifyStatus":25,"verifyTime":193,"verifyNote":26,"syncStatus":28,"languages":194,"translateLanguages":26,"viewCount":36,"subjectFields":195,"manageAffiliations":196,"indexDatabases":197,"url":198,"thumbnailPath":26,"statistic":26,"gsStatistic":199,"type":175,"analyzePriority":26},"f8d0bf97-8d89-482e-b58c-2fc481a0b79b","2025-10-27T06:27:08.591+00:00","2026-06-18T23:33:41.667+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-v%C3%A0-C%C3%B4ng-ngh%E1%BB%87-nhi%E1%BB%87t-%C4%91%E1%BB%9Bi",{"country":183,"introduce":184,"gsId":186,"title":188,"issn":191},{"VOID":15},{"EN":185},"\u003Cp style=\"text-align:justify;\">     Journal of Tropical Science and Engineering (JTSE) is a multidisciplinary scientific journal, licensed to operate as a print journal in 2012 and an electronic journal in 2024 (License No.1479\u002FGP-BTTTT dated August 20, 2012 and No.91\u002FGP-BTTTT dated April 9, 2024 issued by the Ministry of Information and Communications of Vietnam). The JTSE is headquartered in Hanoi.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">        The JTSE is published every 3 months (4 issues\u002Fyear), publishing research results and overview articles in 3 groups of fields: Tropical Ecology and Environment; Chemistry and Material Sciences; Biomedicine and Pharmacy. In 2022, the JTSE registered the international identifier Digital Object Identifier (DOI): 10.58334\u002Fvrtc.jtst and assigned DOI codes to all articles of the journal. The members of the Editorial Board of the JTSE are prestigious scientists and leading scientists from Vietnam and many countries in the world. The JTSE has been recognized by the Vietnam State Council for Professorship to score scientific articles in Chemistry, Medicine and Biology with scores ranging from 0-0.75 points.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">      Currently, the JTSE is building and perfecting a set of criteria and making efforts to join the List of prestigious  international journals with a roadmap to enter Scopus and SCIE in the coming time.\u003C\u002Fp>",{"VOID":187},"MS2_GJQAAAAJ",{"VI":189,"EN":190},"Tạp chí Khoa học và Công nghệ nhiệt đới","Journal of Tropical Science and Engineering",{"VOID":192},"08667535","2025-10-27T06:27:25.058+00:00",[101,102],[],[],[],"https:\u002F\u002Ftapchikhcnnd.com.vn",{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":200,"totalPublicationByYear":201,"totalCitation":161,"totalCitationByYear":203,"totalCitationPerPublication":153,"totalCitationPerPublicationByYear":205,"hindexLast5Year":114,"hindex":114},481,{"0":115,"2020":115,"2021":115,"2022":114,"2024":115,"2025":202,"2026":115},474,{"2017":114,"2018":115,"2019":111,"2020":162,"2021":162,"2022":116,"2023":50,"2024":162,"2025":204,"2026":52},52,{"2020":162,"2021":162,"2022":162,"2024":162,"2025":206,"2026":52},0.11,{"id":208,"createTime":209,"updateTime":210,"relativeEntities":211,"slug":212,"properties":213,"entityType":24,"verifyStatus":25,"verifyTime":221,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":222,"subjectFields":223,"manageAffiliations":224,"indexDatabases":225,"url":226,"thumbnailPath":26,"statistic":227,"gsStatistic":276,"type":175,"analyzePriority":26},"a3d1e82a-57e2-40f9-940e-f5fa8b9ef64a","2023-06-01T07:11:26.039+00:00","2026-06-18T23:33:28.573+00:00",[],"VNU-Journal-of-Science-Earth-and-Environmental-Sciences",{"issn":214,"title":216,"country":218,"gsId":219},{"VOID":215},"26159279",{"EN":217},"VNU Journal of Science: Earth and Environmental Sciences",{"VOID":15},{"VOID":220},"UmXD8vEAAAAJ","2023-06-01T07:17:59.210+00:00",27,[],[],[],"https:\u002F\u002Fjs.vnu.edu.vn\u002FEES",{"impactFactor":36,"impactFactorByYear":228,"i10Index":234,"i10IndexLast5Year":36,"totalPublication":235,"totalPublicationByYear":236,"totalCitation":246,"totalCitationByYear":247,"totalCitationPerPublication":261,"totalCitationPerPublicationByYear":262,"hindexLast5Year":103,"hindex":103},{"2010":229,"2012":40,"2013":230,"2014":230,"2015":231,"2016":54,"2017":171,"2018":109,"2019":110,"2020":57,"2021":232,"2022":233,"2023":151,"2024":58},0.02,0.04,0.09,0.31,0.4,19,656,{"2008":237,"2009":238,"2010":239,"2011":238,"2012":240,"2013":241,"2014":239,"2015":242,"2016":243,"2017":244,"2018":245,"2019":165,"2020":125,"2021":168,"2022":125,"2023":222,"2024":111},23,24,22,28,25,20,146,29,78,1038,{"2008":248,"2009":249,"2010":250,"2011":251,"2012":252,"2013":253,"2014":254,"2015":255,"2016":256,"2017":257,"2018":161,"2019":258,"2020":259,"2021":29,"2022":260},119,64,66,86,38,73,59,31,129,39,97,53,26,1.58,{"2008":263,"2009":264,"2010":59,"2011":265,"2012":266,"2013":267,"2014":268,"2015":269,"2016":270,"2017":271,"2018":272,"2019":272,"2020":273,"2021":274,"2022":275},5.17,2.67,3.58,1.36,2.92,2.68,1.55,0.88,1.34,1.37,1.47,1.24,0.72,{"impactFactor":26,"impactFactorByYear":26,"i10Index":173,"i10IndexLast5Year":135,"totalPublication":277,"totalPublicationByYear":278,"totalCitation":279,"totalCitationByYear":280,"totalCitationPerPublication":288,"totalCitationPerPublicationByYear":289,"hindexLast5Year":158,"hindex":298},113,{"2007":114,"2008":103,"2009":173,"2010":116,"2011":51,"2012":239,"2013":103,"2014":162,"2015":53,"2016":135},616,{"2009":162,"2010":114,"2011":52,"2012":124,"2013":222,"2014":255,"2015":48,"2016":44,"2017":281,"2018":282,"2019":259,"2020":283,"2021":284,"2022":285,"2023":286,"2024":257,"2025":287,"2026":59},54,60,49,47,34,44,33,5.45,{"2009":290,"2010":291,"2011":292,"2012":293,"2013":294,"2014":295,"2015":296,"2016":297},0.28,0.2,0.6,0.77,2.25,6.2,3.91,9.67,14,{"id":300,"createTime":301,"updateTime":302,"relativeEntities":303,"slug":304,"properties":305,"entityType":24,"verifyStatus":25,"verifyTime":316,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":234,"subjectFields":317,"manageAffiliations":318,"indexDatabases":388,"url":389,"thumbnailPath":390,"statistic":391,"gsStatistic":409,"type":175,"analyzePriority":26},"a7166325-6c9e-4db3-8a59-7c879701a372","2023-07-31T04:28:49.231+00:00","2026-06-18T23:33:22.428+00:00",[],"VNU-Journal-of-Science-Policy-and-Management-Studies",{"country":306,"issn":307,"eissn":309,"title":311,"gsId":314},{"VOID":15},{"VOID":308},"26159295",{"VOID":310},"25881116",{"EN":312,"VI":313},"VNU Journal of Science: Policy and Management Studies","Tạp chí Nghiên cứu Chính sách và Quản lý",{"VOID":315},"xKW2E_cAAAAJ","2023-08-01T03:23:46.688+00:00",[],[319],{"id":320,"createTime":321,"updateTime":322,"relativeEntities":323,"slug":324,"properties":325,"entityType":98,"verifyStatus":25,"verifyTime":335,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":336,"url":337,"parentIds":338,"statistic":339},"12466116-8f60-4b01-8faf-2411483a0977","2023-05-30T09:37:38.472+00:00","2026-06-19T02:14:28.352+00:00",[],"Vietnam-National-University",{"country":326,"title":327,"abbreviation":330,"address":332},{"VOID":15},{"EN":328,"VI":329},"Vietnam National University, Hanoi","Đại học Quốc gia Hà Nội",{"VOID":331},"VNU",{"VI":333,"EN":334},"Số 144 Xuân Thủy, Phường Dịch Vọng Hậu, Quận Cầu Giấy, Hà Nội, Việt Nam","No. 144 Xuan Thuy Street, Dich Vong Hau Ward, Cau Giay District, Hanoi, Vietnam","2023-08-02T13:58:17.029+00:00",16,"http:\u002F\u002Fwww.vnu.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":340,"i10Index":285,"i10IndexLast5Year":162,"totalPublication":344,"totalPublicationByYear":345,"totalCitation":354,"totalCitationByYear":355,"totalCitationPerPublication":368,"totalCitationPerPublicationByYear":369,"hindexLast5Year":336,"hindex":336},{"2014":109,"2015":231,"2016":231,"2017":206,"2018":341,"2019":110,"2020":342,"2021":343,"2022":171,"2023":231,"2024":110,"2025":39},0.06,0.18,0.35,1247,{"2003":115,"2004":115,"2005":114,"2006":59,"2007":111,"2008":162,"2009":59,"2010":50,"2011":124,"2012":336,"2013":260,"2014":244,"2015":250,"2016":281,"2017":346,"2018":347,"2019":348,"2020":349,"2021":350,"2022":351,"2023":352,"2024":353,"2025":255,"2026":50},94,88,83,67,176,185,187,93,1644,{"2004":111,"2005":115,"2006":52,"2007":298,"2008":356,"2009":298,"2010":286,"2011":357,"2012":244,"2013":358,"2014":359,"2015":360,"2016":361,"2017":362,"2018":363,"2019":364,"2020":365,"2021":366,"2022":367,"2023":367,"2024":162},13,81,48,70,151,115,109,259,174,181,121,101,1.32,{"2004":111,"2005":370,"2006":59,"2007":371,"2008":372,"2009":373,"2010":374,"2011":375,"2012":376,"2013":377,"2014":378,"2015":379,"2016":380,"2017":381,"2018":382,"2019":383,"2020":384,"2021":385,"2022":386,"2023":387,"2024":109},0.5,3.5,2.6,4.67,5.5,4.76,1.81,1.85,2.41,2.29,2.13,1.16,2.94,2.1,2.7,0.69,0.55,0.54,[],"https:\u002F\u002Fjs.vnu.edu.vn\u002FPaM","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002Fa7166325-6c9e-4db3-8a59-7c879701a372\u002Fecfe83f4bcc60c7023ae04d8900fe0ac.jpg",{"impactFactor":36,"impactFactorByYear":392,"i10Index":111,"i10IndexLast5Year":36,"totalPublication":394,"totalPublicationByYear":395,"totalCitation":399,"totalCitationByYear":400,"totalCitationPerPublication":293,"totalCitationPerPublicationByYear":403,"hindexLast5Year":158,"hindex":158},{"2018":109,"2019":171,"2020":393,"2021":108,"2022":54,"2023":206,"2024":54},0.23,320,{"2015":50,"2016":239,"2017":286,"2018":396,"2019":397,"2020":159,"2021":398,"2022":168,"2023":79,"2024":255},30,35,40,247,{"2015":115,"2016":242,"2017":401,"2018":222,"2019":402,"2020":79,"2021":239,"2022":50,"2023":116},77,50,{"2015":404,"2016":169,"2017":405,"2018":406,"2019":407,"2020":408,"2021":386,"2022":291,"2023":232},0.12,1.75,0.9,1.43,0.86,{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":103,"totalPublicationByYear":410,"totalCitation":234,"totalCitationByYear":411,"totalCitationPerPublication":261,"totalCitationPerPublicationByYear":412,"hindexLast5Year":114,"hindex":59},{"2015":114,"2016":116},{"2016":115,"2017":114,"2018":114,"2019":59,"2020":114,"2021":59,"2022":114,"2023":114,"2024":115,"2026":115},{"2016":108},{"id":414,"createTime":415,"updateTime":416,"relativeEntities":417,"slug":418,"properties":419,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":238,"subjectFields":428,"manageAffiliations":429,"indexDatabases":430,"url":431,"thumbnailPath":26,"statistic":432,"gsStatistic":438,"type":175,"analyzePriority":26},"16e65a3f-d274-47dd-8691-56d76eb58c3d","2023-05-30T09:10:06.062+00:00","2026-06-18T23:33:17.679+00:00",[],"Vietnam-Journal-of-Otorhinolaryngology-Head-and-Neck-Surgery",{"country":420,"issn":421,"title":423,"gsId":426},{"VOID":15},{"VOID":422},"18593704",{"EN":424,"VI":425},"Vietnam Journal of Otorhinolaryngology - Head and Neck Surgery","Tạp chí Tai Mũi Họng Việt Nam",{"VOID":427},"L78B_eIAAAAJ",[],[],[],"https:\u002F\u002Ftapchitaimuihong.vn\u002Findex.php\u002Ftmh",{"impactFactor":36,"impactFactorByYear":433,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":434,"totalPublicationByYear":435,"totalCitation":111,"totalCitationByYear":436,"totalCitationPerPublication":230,"totalCitationPerPublicationByYear":437,"hindexLast5Year":115,"hindex":115},{"2024":229},95,{"2022":52,"2023":286,"2024":255,"2025":53},{"2023":111},{"2023":231},{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":240,"totalPublicationByYear":439,"totalCitation":234,"totalCitationByYear":440,"totalCitationPerPublication":441,"totalCitationPerPublicationByYear":442,"hindexLast5Year":114,"hindex":114},{"2023":53,"2024":116,"2025":135,"2026":115},{"2024":59,"2025":298,"2026":114},0.68,{"2024":443,"2025":444,"2026":114},0.3,2.33,{"id":446,"createTime":447,"updateTime":448,"relativeEntities":449,"slug":450,"properties":451,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":396,"subjectFields":460,"manageAffiliations":461,"indexDatabases":462,"url":463,"thumbnailPath":464,"statistic":465,"gsStatistic":472,"type":175,"analyzePriority":26},"25988add-c322-4eda-afda-63b1559bb824","2023-04-07T03:49:55.817+00:00","2026-06-18T23:32:23.776+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Y%20-%20D%C6%B0%E1%BB%A3c%20h%E1%BB%8Dc%20qu%C3%A2n%20s%E1%BB%B1",{"country":452,"issn":453,"title":455,"gsId":458},{"VOID":15},{"VOID":454},"18590748",{"EN":456,"VI":457},"Journal of Military Pharmaco-medicine","Tạp chí Y - Dược học quân sự",{"VOID":459},"_pmQ8IEAAAAJ",[],[],[],"https:\u002F\u002Fjmpm.vn\u002Findex.php\u002Fjmpm","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F25988add-c322-4eda-afda-63b1559bb824\u002F09c6bc42157cf5ece95edc971ccddb52.jpg",{"impactFactor":36,"impactFactorByYear":466,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":467,"totalPublicationByYear":468,"totalCitation":135,"totalCitationByYear":470,"totalCitationPerPublication":38,"totalCitationPerPublicationByYear":471,"hindexLast5Year":115,"hindex":115},{"2023":229,"2024":38},475,{"2022":168,"2023":365,"2024":469,"2025":124},236,{"2022":114,"2023":111},{"2022":109,"2023":229},{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":277,"totalPublicationByYear":473,"totalCitation":401,"totalCitationByYear":474,"totalCitationPerPublication":441,"totalCitationPerPublicationByYear":475,"hindexLast5Year":59,"hindex":59},{"2015":115,"2018":114,"2019":115,"2020":115,"2021":59,"2022":103,"2023":159,"2024":287,"2025":237},{"2020":115,"2021":115,"2022":115,"2023":52,"2024":237,"2025":79,"2026":116},{"2020":115,"2021":476,"2022":171,"2023":477,"2024":478,"2025":479},0.33,0.24,0.7,1.39,{"id":481,"createTime":482,"updateTime":483,"relativeEntities":484,"slug":485,"properties":486,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":496,"translateLanguages":26,"viewCount":45,"subjectFields":497,"manageAffiliations":498,"indexDatabases":525,"url":526,"thumbnailPath":527,"statistic":528,"gsStatistic":26,"type":26,"analyzePriority":26},"2b8d7b12-2d20-4777-be98-077f44f03c69","2023-09-07T07:40:58.286+00:00","2025-07-13T21:21:00.542+00:00",[],"VNU-Journal-of-Social-Sciences-and-Humanities",{"country":487,"issn":488,"introduce":490,"title":493},{"VOID":15},{"VOID":489},"23541172",{"EN":491,"VI":492},"{\"ops\":[{\"insert\":\"VNU Journal of Social Sciences and Humanities (ISSN 2354-1172) is a double-blind peer-reviewed journal published by University of Social Sciences and Humanities, Vietnam National University, Hanoi, Vietnam, under the publication permit no. 155\u002FGP-BTTTT, issued on 11\"},{\"attributes\":{\"script\":\"super\"},\"insert\":\"th \"},{\"insert\":\"May, 2015 by Ministry of Information and Communications. The journal publishes four Vietnamese issues and two English issues per year.\\nCurrently, there are 35 reputable professors in the editorial board. The main objectives of the journal include: providing an intellectual platform for Vietnamese and international scholars; promoting interdisciplinary studies in social sciences and humanities; becoming the leading journal in social sciences and humanities in Vietnam; being indexed by worldwide databases and having academic recognition internationally in the near future.\\nThe journal is currently indexed by Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services and Vietnam National University’s digital archive.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Journal of Social Sciences and Humanities-Vietnam\"},{\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"ISSN 2354-1172, email: tapchikhxhnv@gmail.com, tckhxhnv@vnu.edu.vn\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Được thành lập ngày 31\u002F8\u002F2015 (giấy phép hoạt động số 155\u002FGP-BVHTT ngày 11 tháng 5 năm 2015 của Bộ Thông tin và Truyền thông, mã số tiêu chuẩn quốc tế ISSN 2354-1172), Tạp chí Khoa học Xã hội và Nhân văn (Journal of Social Sciences and Humanities) là ấn phẩm khoa học chính thức, duy nhất của Trường Đại học Khoa học Xã hội và Nhân văn, ĐHQG Hà Nội, phát triển và kế thừa Chuyên san Khoa học Xã hội và Nhân văn, Tạp chí Khoa học, ĐHQG Hà Nội.\\nTạp chí xuất bản định kỳ (04 số tiếng Việt\u002Fnăm và 02 số tiếng Anh\u002Fnăm), có nhiệm vụ \"},{\"attributes\":{\"italic\":true},\"insert\":\"công bố, giới thiệu các công trình nghiên cứu khoa học khoa học xã hội và nhân văn của các tác giả là các nhà khoa học trong và ngoài nước, phục vụ giảng dạy, học tập và nghiên cứu khoa học\"},{\"insert\":\". Hội đồng biên tập của Tạp chí hiện bao gồm 33 nhà khoa học có uy tín trong nước và quốc tế. Tạp chí tập trung và ưu tiên đăng tải những bài báo theo định hướng của tinh thần cởi mở, sáng tạo, nhanh chóng vươn lên để tiếp cận và sánh ngang với các tạp chí có uy tín hàng đầu của khu vực và trên thế giới. Nội dung chính của Tạp chí bao gồm các Bài nghiên cứu (khoảng 6000 đến 15000 từ), các bài điểm sách, thông tin khoa học (khoảng 300 đến 1500 từ) được trình bày theo đúng cấu trúc và chuẩn mực của một tạp chí khoa học.\\nCác bài viết của Tạp chí hiện đang được trích dẫn bởi Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services.\\nMọi thông tin xin liên hệ: \"},{\"attributes\":{\"italic\":true},\"insert\":\"Phòng Tạp chí, 701 - E, Trường Đại học Khoa học Xã hội và Nhân văn, 336 Nguyễn Trãi, Thanh Xuân, Hà Nội. ĐT: 024.35581984; email: tckhxhnv@vnu.edu.vn \"},{\"insert\":\"hoặc \"},{\"attributes\":{\"italic\":true},\"insert\":\"tapchikhxhnv@gmail.com \"},{\"insert\":\"\\n\"}]}",{"EN":494,"VI":495},"VNU Journal of Social Sciences and Humanities","Tạp chí Khoa học Xã hội và Nhân văn",[101,102],[],[499],{"id":500,"createTime":501,"updateTime":502,"relativeEntities":503,"slug":504,"properties":505,"entityType":98,"verifyStatus":25,"verifyTime":509,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":222,"url":26,"parentIds":510,"statistic":511},"8b6e349b-0daf-4895-9c3f-85f30f1bfd42","2023-07-31T12:55:58.430+00:00","2026-06-19T02:30:07.899+00:00",[],"Tr%C6%B0%E1%BB%9Dng-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Khoa-h%E1%BB%8Dc-X%C3%A3-h%E1%BB%99i-v%C3%A0-Nh%C3%A2n-v%C4%83n-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-H%C3%A0-N%E1%BB%99i",{"title":506},{"EN":507,"VI":508},"VNU University of Social Sciences and Humanities","Trường Đại học Khoa học Xã hội và Nhân văn, Đại học Quốc gia Hà Nội","2023-08-02T15:28:49.057+00:00",[],{"impactFactor":36,"impactFactorByYear":512,"i10Index":59,"i10IndexLast5Year":115,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":518,"totalCitationByYear":519,"totalCitationPerPublication":520,"totalCitationPerPublicationByYear":521,"hindexLast5Year":162,"hindex":162},{"2016":229,"2017":230,"2018":229,"2021":230,"2022":58,"2023":513,"2024":38},0.15,365,{"2013":115,"2014":158,"2015":125,"2016":252,"2017":44,"2018":516,"2019":286,"2020":396,"2021":259,"2022":517,"2023":396,"2024":115,"2025":59,"2026":115},21,42,169,{"2015":283,"2016":135,"2017":52,"2018":50,"2019":298,"2020":53,"2021":359,"2022":115,"2023":115},0.46,{"2015":266,"2016":57,"2017":57,"2018":522,"2019":523,"2020":524,"2021":368,"2022":229,"2023":39},0.38,0.32,0.37,[],"http:\u002F\u002Fjournal.ussh.vnu.edu.vn\u002Findex.php\u002Fvjossh","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F2b8d7b12-2d20-4777-be98-077f44f03c69\u002F0bd0751202944a4b4165b482e6e623e4.png",{"impactFactor":36,"impactFactorByYear":529,"i10Index":162,"i10IndexLast5Year":115,"totalPublication":530,"totalPublicationByYear":531,"totalCitation":537,"totalCitationByYear":538,"totalCitationPerPublication":343,"totalCitationPerPublicationByYear":540,"hindexLast5Year":135,"hindex":135},{"2016":341,"2017":39,"2018":229,"2019":38,"2020":110,"2021":231,"2022":231,"2023":341,"2024":39},764,{"2015":255,"2016":245,"2017":532,"2018":259,"2019":533,"2020":534,"2021":535,"2022":536,"2023":534,"2024":254,"2025":50},111,106,68,92,89,265,{"2015":539,"2016":241,"2017":168,"2018":51,"2019":349,"2020":260,"2021":244,"2022":298,"2023":114},46,{"2015":541,"2016":523,"2017":524,"2018":290,"2019":542,"2020":522,"2021":523,"2022":57,"2023":39},1.48,0.63,{"id":544,"createTime":545,"updateTime":546,"relativeEntities":547,"slug":548,"properties":549,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":558,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":50,"subjectFields":559,"manageAffiliations":560,"indexDatabases":561,"url":562,"thumbnailPath":563,"statistic":564,"gsStatistic":26,"type":26,"analyzePriority":26},"6ec01bd0-15c0-469a-86ac-41339076ae0a","2023-08-10T07:08:33.153+00:00","2026-01-31T21:19:06.362+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Da-li%E1%BB%85u-h%E1%BB%8Dc-Vi%E1%BB%87t-Nam",{"country":550,"issn":551,"introduce":553,"title":555},{"VOID":15},{"VOID":552},"18594824",{"VI":554},"{\"ops\":[{\"insert\":\"Tạp chí “Da liễu học Việt Nam” (Tiếng Anh: Vietnamese Journal of Dermatology and Venereology) thuộc Hội Da liễu Việt Nam, xuất bản 4 số mỗi năm bằng tiếng Việt hoặc tiếng Anh.\\nTạp chí Da liễu học Việt Nam hoạt động với mục đích, tôn chỉ là phổ biến, trao đổi thông tin trong lĩnh vực chuyên ngành da liễu; đăng tải các công trình nghiên cứu khoa học; chuyển giao công nghệ - kinh tế và khoa học kỹ thuật liên quan đến lĩnh vực da liễu.\\nPhạm vi của tạp chí là tất cả các bài báo khoa học, bài tổng quan, giới thiệu ca lâm sàng, … có liên quan tới chuyên ngành da liễu trong và ngoài nước. Tạp chí công bố các công trình nghiên cứu liên quan đến mô hình bệnh tật, các phương pháp chẩn đoán, điều trị, dự phòng và phục hồi chức năng các bệnh thuộc chuyên ngành da liễu. Ngoài ra, tạp chí còn đăng tải các bài tổng quan, cập nhật thông tin, kiến thức, hướng dẫn chẩn đoán, điều trị trong chuyên ngành da liễu trong nước và quốc tế; đăng tải các bài ca lâm sàng đặc biệt trong chuyên ngành da liễu.\\nTạp chí Da liễu học Việt Nam được biết tới là một tạp chí chuyên ngành có uy tín trong lĩnh vực da liễu. Các bài báo về nghiên cứu khoa học đăng trong Tạp chí được bình duyệt một cách nghiêm ngặt bởi ít nhất 2 chuyên gia. Hội đồng biên tập tạp chí bao gồm các nhà khoa học có uy tín (Giáo sư, Phó Giáo sư, Tiến sĩ, Bác sĩ…) trong chuyên ngành da liễu nhằm đảm bảo chất lượng và tính khách quan, khoa học cho các bài viết đăng trên Tạp chí.\\n\"}]}",{"EN":556,"VI":557},"Vietnamese Journal of Dermatology and Venereology","Tạp chí Da liễu học Việt Nam","Admin Import",[],[],[],"https:\u002F\u002Fvjdv.vn\u002Findex.php\u002Fvjdv","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F6ec01bd0-15c0-469a-86ac-41339076ae0a\u002F3cbc81720e58429dc7b1c4d7ab1935ca.jpg",{"impactFactor":36,"impactFactorByYear":565,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":566,"totalPublicationByYear":567,"totalCitation":116,"totalCitationByYear":570,"totalCitationPerPublication":109,"totalCitationPerPublicationByYear":571,"hindexLast5Year":115,"hindex":115},{"2023":38,"2024":230},182,{"2022":568,"2023":45,"2024":569},69,56,{"2022":52,"2023":115},{"2022":40,"2023":229},{"id":573,"createTime":574,"updateTime":575,"relativeEntities":576,"slug":577,"properties":578,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":587,"translateLanguages":26,"viewCount":283,"subjectFields":588,"manageAffiliations":589,"indexDatabases":647,"url":648,"thumbnailPath":649,"statistic":650,"gsStatistic":26,"type":26,"analyzePriority":26},"19221551-7519-47ff-a892-331d1139c64b","2023-09-12T07:03:05.744+00:00","2026-01-24T20:54:40.144+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-S%E1%BB%A9c-kho%E1%BA%BB-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-Th%C3%A0nh-ph%E1%BB%91-H%E1%BB%93-Ch%C3%AD-Minh",{"country":579,"issn":580,"introduce":582,"title":584},{"VOID":15},{"VOID":581},"27349446",{"EN":583},"{\"ops\":[{\"attributes\":{\"bold\":true},\"insert\":\"1. History\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Science and Technology Development Journal\"},{\"insert\":\" (STDJ) (ISSN 2734-9446), Vietnam National University - Ho Chi Minh City (VNU-HCM) was established in 1997. And the first issue was published in January 1998 with ISSN 1859-0128. Since then, STDJ has become the most important scientific forum of scientists from VNU-HCM as well as other universities. The magazine has undergone 20 years of development and has become a bridge for scientific exchanges, as well as enriching reference materials for the faculty, doctoral students, students of VNU-HCM in particular and other universities, institutes...\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal since 2020.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\" \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"2. Focus and Scope\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Publishing articles with contents on healthcare, research projects in the field of health, advanced directions in health education and management. Therefore, STDJ-HS will accept articles from doctors, administrators, teachers, researchers, graduate students and fellows. The authors will be responsible for the accuracy of the data, opinions, opinions and material cited in the article.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Facilitating the exchange of scientific and technological information and act as a bridge between theory and practice in the community of educators, scientists, managers, policy makers and enterprises in and out of the country.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}",{"EN":585,"VI":586},"VNUHCM JOURNAL OF HEALTH SCIENCES","Tạp chí Khoa học Sức khoẻ Đại học Quốc gia Thành phố Hồ Chí Minh",[101,102],[],[590],{"id":591,"createTime":592,"updateTime":593,"relativeEntities":594,"slug":595,"properties":596,"entityType":98,"verifyStatus":25,"verifyTime":606,"verifyNote":26,"syncStatus":28,"languages":607,"translateLanguages":26,"viewCount":608,"url":609,"parentIds":610,"statistic":611},"fc4c2560-868c-4677-acb1-8686bef88727","2023-06-26T04:48:23.774+00:00","2026-06-19T01:46:17.248+00:00",[],"%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-Th%C3%A0nh-ph%E1%BB%91-H%E1%BB%93-Ch%C3%AD-Minh",{"country":597,"title":598,"abbreviation":601,"address":603},{"VOID":15},{"EN":599,"VI":600},"Vietnam National University Ho Chi Minh City","Đại học Quốc gia Thành phố Hồ Chí Minh",{"VOID":602},"VNUHCM",{"VI":604,"EN":605},"khu phố 6, Phường Linh Trung, Thành phố Thủ Đức, Thành phố Hồ Chí Minh, Việt Nam","Quarter 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam","2023-08-16T14:13:07.134+00:00",[101,102],45,"https:\u002F\u002Fvnuhcm.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":612,"i10Index":285,"i10IndexLast5Year":51,"totalPublication":613,"totalPublicationByYear":614,"totalCitation":624,"totalCitationByYear":625,"totalCitationPerPublication":634,"totalCitationPerPublicationByYear":635,"hindexLast5Year":124,"hindex":124},{"2014":36,"2015":38,"2016":109,"2017":39,"2018":229,"2019":38,"2020":110,"2021":171,"2022":110,"2023":110,"2024":171,"2025":229},3708,{"2005":115,"2006":115,"2007":115,"2008":135,"2009":111,"2010":53,"2011":52,"2012":568,"2013":615,"2014":351,"2015":616,"2016":469,"2017":617,"2018":127,"2019":618,"2020":619,"2021":620,"2022":621,"2023":622,"2024":623,"2025":159,"2026":50},164,266,177,226,603,931,314,246,74,2399,{"2006":115,"2008":50,"2010":162,"2011":242,"2012":222,"2013":43,"2014":626,"2015":627,"2016":628,"2017":629,"2018":258,"2019":630,"2020":631,"2021":632,"2022":633,"2023":353,"2024":115},250,124,157,162,152,385,559,128,0.65,{"2006":115,"2008":636,"2010":637,"2011":638,"2012":639,"2013":522,"2014":640,"2015":641,"2016":642,"2017":643,"2018":644,"2019":642,"2020":645,"2021":292,"2022":646,"2023":522,"2024":38},1.33,0.45,2.22,0.39,1.35,0.47,0.67,0.92,0.73,0.64,0.41,[],"http:\u002F\u002Fstdjhs.scienceandtechnology.com.vn\u002Findex.php\u002Fstdjhs","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F19221551-7519-47ff-a892-331d1139c64b\u002F2e10768b7d1e380c36a25ed0c714dd7e.png",{"impactFactor":36,"impactFactorByYear":651,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":652,"totalPublicationByYear":653,"totalCitation":516,"totalCitationByYear":654,"totalCitationPerPublication":151,"totalCitationPerPublicationByYear":655,"hindexLast5Year":59,"hindex":59},{"2022":57,"2023":108,"2024":39},79,{"2020":116,"2021":240,"2022":239,"2023":52,"2024":162,"2025":162},{"2020":59,"2021":51,"2022":59},{"2020":443,"2021":387,"2022":54},{"code":657,"data":658,"meta":26},"SUCCESS",{"id":659,"createTime":660,"updateTime":661,"relativeEntities":662,"slug":663,"properties":664,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":675,"manageAffiliations":700,"indexDatabases":721,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},"927c69a7-42e5-4fa5-998d-55f42cbf1f51","2023-05-29T11:22:33.557+00:00","2025-11-21T09:52:31.928+00:00",[],"Stem-cells-translational-medicine",{"country":665,"issn":667,"introduce":669,"eissn":671,"title":673},{"VOID":666},"US",{"VOID":668},"21576564",{"EN":670},"STEM CELLS Translational Medicine is a monthly, peer-reviewed, largely online, open access journal. STEM CELLS Translational Medicine works to advance the utilization of cells for clinical therapy. By bridging stem cell molecular and biological research and helping speed translations of emerging lab discoveries into clinical trials, STEM CELLS Translational Medicine will help move applications of these critical investigations closer to accepted best patient practices and ultimately improve outcomes. The journal encourages original research articles and concise reviews describing laboratory investigations of stem cells, including their characterization and manipulation, and the translation of their clinical aspects of from the bench to patient care. STEM CELLS Translational Medicine covers all aspects of translational cell studies, including bench research, first-in-human case studies, and relevant clinical trials.",{"VOID":672},"21576580",{"EN":674},"Stem cells translational medicine",[676,684,692],{"id":677,"createTime":678,"updateTime":679,"relativeEntities":680,"label":681,"description":683,"parentId":26,"standard":26,"scholarHubFieldId":26},"9de9264a-b4da-47bc-9bf5-3619dcd183d7","2023-05-29T10:24:56.525+00:00","2023-11-21T07:54:54.944+00:00",[],{"EN":682},"Developmental Biology",{},{"id":685,"createTime":686,"updateTime":687,"relativeEntities":688,"label":689,"description":691,"parentId":26,"standard":26,"scholarHubFieldId":26},"131e254e-0b02-478f-aa3e-0b27d8c7b9d1","2023-05-29T10:24:28.895+00:00","2023-11-21T07:54:54.939+00:00",[],{"EN":690},"Cell Biology",{},{"id":693,"createTime":694,"updateTime":695,"relativeEntities":696,"label":697,"description":699,"parentId":26,"standard":26,"scholarHubFieldId":26},"0254e3e5-c28d-4a33-83da-81bc94d29ffd","2023-05-29T10:24:00.931+00:00","2023-11-21T07:56:41.438+00:00",[],{"EN":698},"Medicine (miscellaneous)",{},[701,711],{"id":702,"createTime":703,"updateTime":704,"relativeEntities":705,"slug":706,"properties":707,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":111,"url":26,"parentIds":710,"statistic":26},"2bc101c3-b2fa-462b-9498-b1c3a2f9ba51","2023-05-29T12:08:02.996+00:00","2024-02-18T12:06:12.696+00:00",[],"OXFORD-UNIV-PRESS",{"title":708},{"EN":709},"OXFORD UNIV PRESS",[],{"id":712,"createTime":713,"updateTime":714,"relativeEntities":715,"slug":716,"properties":717,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":111,"url":26,"parentIds":720,"statistic":26},"3b2b3c1e-d793-4160-89dd-eb4e42b70e4a","2023-05-29T10:24:01.308+00:00","2025-11-21T10:07:42.786+00:00",[],"Oxford-University-Press",{"title":718},{"EN":719},"Oxford University Press",[],[722,741],{"id":723,"indexDatabase":724,"url":738,"indexYears":26,"academicFieldIds":739,"indexDatabaseRanking":26},"a539ab45-4f08-49c5-90f9-d93f7efcb2d3",{"id":725,"createTime":726,"updateTime":727,"relativeEntities":728,"label":729,"description":731,"key":734,"publicationTags":735,"standard":26},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":730,"VI":730},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":732,"EN":733},"Cơ sở dữ liệu SCIE","SCIE database","scie",[736,737],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=2157-6564",[740],"a1c05535-e0d3-4afa-969d-9ceb802dc5fd",{"id":742,"indexDatabase":743,"url":755,"indexYears":756,"academicFieldIds":757,"indexDatabaseRanking":761},"cc755dde-5057-474b-af7a-20415bc7fcfc",{"id":744,"createTime":745,"updateTime":746,"relativeEntities":747,"label":748,"description":750,"key":752,"publicationTags":753,"standard":26},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":749,"VI":749},"Scopus - Elsevier",{"EN":749,"VI":751},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[754],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21100225608","2012-2025",[758,759,760],"e89cebf4-fecf-4b74-8ab4-88fca891e4c2","77a1f344-c35c-4e7a-b456-46d934d12f01","d2139bd1-2fdb-481b-a416-9c30dd0cc173","SCOPUS__Q1","https:\u002F\u002Fstemcellsjournals.onlinelibrary.wiley.com\u002Fjournal\u002F21576580",{"meta":764,"data":766},{"total":765},"30",[767,1211,1751,2723,3033,3371,3813,4051,4471,5297],{"id":768,"createTime":769,"updateTime":770,"relativeEntities":771,"slug":772,"properties":773,"entityType":792,"verifyStatus":25,"verifyTime":769,"verifyNote":793,"syncStatus":28,"languages":794,"translateLanguages":795,"viewCount":36,"primaryUrl":796,"fullTextUrl":26,"authors":797,"publicationType":877,"publisherRelationship":878,"citationCount":911,"citationInfo":912,"publishDate":915,"publishYear":916,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":917,"isForceReanalyzing":1210},"c5783dd2-ae5e-4e38-ace2-ec73362c7939","2024-10-16T03:17:51.013+00:00","2025-02-22T15:10:57.084+00:00",[],"Concise-Review-Role-of-Mesenchymal-Stem-Cells-in-Wound-Repair",{"mag":774,"keywords":776,"pmc":778,"openalex":780,"abstract":782,"title":785,"pm":788,"doi":790},{"VOID":775},"2153405392",{"VI":777},"",{"VOID":779},"3659685",{"VOID":781},"W2153405392",{"EN":783,"VI":784},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Wound healing requires a coordinated interplay among cells, growth factors, and extracellular matrix proteins. Central to this process is the endogenous mesenchymal stem cell (MSC), which coordinates the repair response by recruiting other host cells and secreting growth factors and matrix proteins. MSCs are self-renewing multipotent stem cells that can differentiate into various lineages of mesenchymal origin such as bone, cartilage, tendon, and fat. In addition to multilineage differentiation capacity, MSCs regulate immune response and inflammation and possess powerful tissue protective and reparative mechanisms, making these cells attractive for treatment of different diseases. The beneficial effect of exogenous MSCs on wound healing was observed in a variety of animal models and in reported clinical cases. Specifically, they have been successfully used to treat chronic wounds and stimulate stalled healing processes. Recent studies revealed that human placental membranes are a rich source of MSCs for tissue regeneration and repair. This review provides a concise summary of current knowledge of biological properties of MSCs and describes the use of MSCs for wound healing. In particular, the scope of this review focuses on the role MSCs have in each phase of the wound-healing process. In addition, characterization of MSCs containing skin substitutes is described, demonstrating the presence of key growth factors and cytokines uniquely suited to aid in wound repair.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Việc hồi phục vết thương đòi hỏi một sự tương tác phối hợp giữa các tế bào, yếu tố tăng trưởng và protein ma trận ngoại bào. Tế bào gốc trung mô (MSC) nội sinh là trung tâm của quá trình này, góp phần điều phối phản ứng sửa chữa bằng cách thu hút các tế bào khác từ cơ thể và tiết ra các yếu tố tăng trưởng cùng protein ma trận. MSC là những tế bào gốc đa năng có khả năng tự phục hồi, có thể biệt hóa thành nhiều loại tế bào có nguồn gốc trung mô khác nhau như xương, sụn, gân và mỡ. Ngoài khả năng biệt hóa đa dòng, MSC còn điều hòa phản ứng miễn dịch và viêm, đồng thời sở hữu các cơ chế bảo vệ và sửa chữa mô mạnh mẽ, khiến cho các tế bào này trở nên hấp dẫn cho việc điều trị nhiều bệnh lý khác nhau. Hiệu quả tích cực của MSC ngoại sinh trong việc hồi phục vết thương đã được quan sát thấy ở nhiều mô hình động vật và trong các trường hợp lâm sàng đã được báo cáo. Cụ thể, chúng đã được sử dụng thành công để điều trị các vết thương mạn tính và kích thích các quá trình lành lại đã bị ngưng trệ. Các nghiên cứu gần đây đã phát hiện ra rằng màng nhau thai người là nguồn giàu MSC cho việc tái tạo và sửa chữa mô. Bài tổng quan này cung cấp một tóm tắt ngắn gọn về những hiểu biết hiện tại về các thuộc tính sinh học của MSC và mô tả việc sử dụng MSC trong hồi phục vết thương. Đặc biệt, phạm vi của bài tổng quan này tập trung vào vai trò của MSC trong từng giai đoạn của quá trình hồi phục vết thương. Ngoài ra, sự đặc trưng của MSC chứa tế bào thay thế da cũng được mô tả, cho thấy sự hiện diện của các yếu tố tăng trưởng và cytokine chủ chốt đặc biệt phù hợp để hỗ trợ trong việc sửa chữa vết thương.\u003C\u002Fjats:p>",{"EN":786,"VI":787},"Concise Review: Role of Mesenchymal Stem Cells in Wound Repair","Tổng quan ngắn gọn: Vai trò của tế bào gốc trung mô trong quá trình phục hồi vết thương",{"VOID":789},"23197761",{"VOID":791},"10.5966\u002Fsctm.2011-0018","PUBLICATION","Auto Verify",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F1\u002F2\u002F142-149\u002F6386961",[798,817,832,847,862],{"id":799,"sortIndex":115,"researcher":26,"roles":800,"affiliations":801,"properties":812},"4333a5cf-aa79-475e-ba62-018c16a886b3",[],[802],{"id":803,"sortIndex":36,"affiliation":804,"properties":26},"9369b652-3d05-489d-8737-142bc42cb11f",{"id":805,"createTime":806,"updateTime":806,"relativeEntities":807,"slug":808,"properties":809,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a95bb45a-0423-4354-bbf4-f04fbb0f4461","2024-10-16T03:17:51.029+00:00",[],"Osiris-Therapeutics-Inc-Columbia-Maryland-USA",{"title":810},{"EN":811},"Osiris Therapeutics, Inc., Columbia, Maryland, USA",{"openalex":813,"title":815},{"VOID":814},"A5053029409",{"EN":816},"Erasmo A. Lopez",{"id":818,"sortIndex":59,"researcher":26,"roles":819,"affiliations":820,"properties":827},"e4aa8519-71c8-4180-8490-6c41d60aa4a8",[],[821],{"id":822,"sortIndex":36,"affiliation":823,"properties":26},"bd495480-70e0-4c8c-9f21-c5db9ab978c7",{"id":805,"createTime":806,"updateTime":806,"relativeEntities":824,"slug":808,"properties":825,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":826},{"EN":811},{"openalex":828,"title":830},{"VOID":829},"A5046790660",{"EN":831},"Alla Danilkovitch‐Miagkova",{"id":833,"sortIndex":114,"researcher":26,"roles":834,"affiliations":835,"properties":842},"bd67bdbb-6b14-4cd0-a392-b50755187f8d",[],[836],{"id":837,"sortIndex":36,"affiliation":838,"properties":26},"17015c70-60f5-43d9-b287-c146ea4123e4",{"id":805,"createTime":806,"updateTime":806,"relativeEntities":839,"slug":808,"properties":840,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":841},{"EN":811},{"openalex":843,"title":845},{"VOID":844},"A5034172463",{"EN":846},"Dana Yoo",{"id":848,"sortIndex":111,"researcher":26,"roles":849,"affiliations":850,"properties":857},"000fce13-2c43-4e71-946d-9735c542701a",[],[851],{"id":852,"sortIndex":36,"affiliation":853,"properties":26},"f191597c-9418-4dbd-b556-a8be1aebbb2a",{"id":805,"createTime":806,"updateTime":806,"relativeEntities":854,"slug":808,"properties":855,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":856},{"EN":811},{"openalex":858,"title":860},{"VOID":859},"A5076182862",{"EN":861},"Michelle A. LeRoux",{"id":863,"sortIndex":36,"researcher":26,"roles":864,"affiliations":865,"properties":872},"7cf9e95e-6e35-4b1e-a54b-89c1e428c360",[],[866],{"id":867,"sortIndex":36,"affiliation":868,"properties":26},"e6bf0d02-b848-4db1-b971-79b870ffa635",{"id":805,"createTime":806,"updateTime":806,"relativeEntities":869,"slug":808,"properties":870,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":871},{"EN":811},{"openalex":873,"title":875},{"VOID":874},"A5004286032",{"EN":876},"Scott Maxson","ARTICLE",{"url":26,"publisher":879,"properties":904},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":880,"slug":663,"properties":881,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":887,"manageAffiliations":888,"indexDatabases":889,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":882,"issn":883,"introduce":884,"eissn":885,"title":886},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[890,897],{"id":742,"indexDatabase":891,"url":755,"indexYears":756,"academicFieldIds":896,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":892,"label":893,"description":894,"key":752,"publicationTags":895,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":898,"url":738,"indexYears":26,"academicFieldIds":903,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":899,"label":900,"description":901,"key":734,"publicationTags":902,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":905,"pages":907,"issue":909},{"VOID":906},"1",{"VOID":908},"142-149",{"VOID":910},"2",725,{"total":911,"publishYear":26,"statisticByYear":913},{"2012":115,"2013":255,"2014":259,"2015":359,"2016":117,"2017":359,"2018":652,"2019":914,"2020":44,"2021":165,"2022":608,"2023":204,"2024":358},62,"2012-02-01",2012,[918,922,926,930,933,937,941,945,949,953,957,961,965,969,973,977,981,985,989,993,996,1000,1004,1008,1012,1016,1020,1024,1028,1032,1036,1040,1044,1048,1052,1056,1060,1064,1068,1072,1076,1080,1084,1088,1092,1096,1100,1104,1108,1112,1116,1120,1124,1128,1131,1135,1139,1143,1147,1151,1155,1158,1161,1165,1169,1173,1177,1181,1185,1189,1192,1196,1200,1204,1206],{"id":26,"text":919,"url":26,"identifiers":920},"Hanson, 2010, Mesenchymal stem cell therapy for nonhealing cutaneous wounds, Plast Reconstr Surg, 125, 510, 10.1097\u002FPRS.0b013e3181c722bb",{"doi":921},"10.1097\u002FPRS.0b013e3181c722bb",{"id":26,"text":923,"url":26,"identifiers":924},"Mustoe, 2006, Chronic wound pathogenesis and current treatment strategies: A unifying hypothesis, Plast Reconstr Surg, 117, 35S, 10.1097\u002F01.prs.0000225431.63010.1b",{"doi":925},"10.1097\u002F01.prs.0000225431.63010.1b",{"id":26,"text":927,"url":26,"identifiers":928},"Sellheyer, 2010, Cutaneous mesenchymal stem cells. Current status of research and potential clinical applications, Hautarzt, 61, 429, 10.1007\u002Fs00105-010-1919-6",{"doi":929},"10.1007\u002Fs00105-010-1919-6",{"id":26,"text":931,"url":26,"identifiers":932},"Paquet-Fifield, 2009, A role for pericytes as microenvironmental regulators of human skin tissue regeneration, J Clin Invest, 119, 2795",{},{"id":26,"text":934,"url":26,"identifiers":935},"Krampera, 2006, Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair, Bone, 39, 678, 10.1016\u002Fj.bone.2006.04.020",{"doi":936},"10.1016\u002Fj.bone.2006.04.020",{"id":26,"text":938,"url":26,"identifiers":939},"Rahaman, 2005, Stem cell-based composite tissue constructs for regenerative medicine, Biotechnol Bioeng, 91, 261, 10.1002\u002Fbit.20292",{"doi":940},"10.1002\u002Fbit.20292",{"id":26,"text":942,"url":26,"identifiers":943},"Polak, 2006, Stem cells and tissue engineering: Past, present, and future, Ann N Y Acad Sci, 1068, 352, 10.1196\u002Fannals.1346.001",{"doi":944},"10.1196\u002Fannals.1346.001",{"id":26,"text":946,"url":26,"identifiers":947},"Raghunath, 2005, Advancing cartilage tissue engineering: The application of stem cell technology, Curr Opin Biotechnol, 16, 503, 10.1016\u002Fj.copbio.2005.08.004",{"doi":948},"10.1016\u002Fj.copbio.2005.08.004",{"id":26,"text":950,"url":26,"identifiers":951},"da Silva Meirelles, 2008, In search of the in vivo identity of mesenchymal stem cells, Stem Cells, 26, 2287, 10.1634\u002Fstemcells.2007-1122",{"doi":952},"10.1634\u002Fstemcells.2007-1122",{"id":26,"text":954,"url":26,"identifiers":955},"Sakaguchi, 2005, Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source, Arthritis Rheum, 52, 2521, 10.1002\u002Fart.21212",{"doi":956},"10.1002\u002Fart.21212",{"id":26,"text":958,"url":26,"identifiers":959},"Hwang, 2009, Comparison of cytokine expression in mesenchymal stem cells from human placenta, cord blood, and bone marrow, J Korean Med Sci, 24, 547, 10.3346\u002Fjkms.2009.24.4.547",{"doi":960},"10.3346\u002Fjkms.2009.24.4.547",{"id":26,"text":962,"url":26,"identifiers":963},"Tsai, 2007, Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow, Stem Cells, 25, 2511, 10.1634\u002Fstemcells.2007-0023",{"doi":964},"10.1634\u002Fstemcells.2007-0023",{"id":26,"text":966,"url":26,"identifiers":967},"Dominici, 2006, Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, 8, 315, 10.1080\u002F14653240600855905",{"doi":968},"10.1080\u002F14653240600855905",{"id":26,"text":970,"url":26,"identifiers":971},"Barlow, 2008, Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells, Stem Cells Dev, 17, 1095, 10.1089\u002Fscd.2007.0154",{"doi":972},"10.1089\u002Fscd.2007.0154",{"id":26,"text":974,"url":26,"identifiers":975},"Miao, 2006, Isolation of mesenchymal stem cells from human placenta: Comparison with human bone marrow mesenchymal stem cells, Cell Biol Int, 30, 681, 10.1016\u002Fj.cellbi.2006.03.009",{"doi":976},"10.1016\u002Fj.cellbi.2006.03.009",{"id":26,"text":978,"url":26,"identifiers":979},"Parolini, 2008, Concise review: Isolation and characterization of cells from human term placenta: Outcome of the first International Workshop on Placenta Derived Stem Cells, Stem Cells, 26, 300, 10.1634\u002Fstemcells.2007-0594",{"doi":980},"10.1634\u002Fstemcells.2007-0594",{"id":26,"text":982,"url":26,"identifiers":983},"Poloni, 2008, Characterization and expansion of mesenchymal progenitor cells from first-trimester chorionic villi of human placenta, Cytotherapy, 10, 690, 10.1080\u002F14653240802419310",{"doi":984},"10.1080\u002F14653240802419310",{"id":26,"text":986,"url":26,"identifiers":987},"Banas, 2008, Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells, Hum Immunol, 69, 321, 10.1016\u002Fj.humimm.2008.04.007",{"doi":988},"10.1016\u002Fj.humimm.2008.04.007",{"id":26,"text":990,"url":26,"identifiers":991},"Magatti, 2008, Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities, Stem Cells, 26, 182, 10.1634\u002Fstemcells.2007-0491",{"doi":992},"10.1634\u002Fstemcells.2007-0491",{"id":26,"text":994,"url":26,"identifiers":995},"Pool, 1977, Normal Hemostatic Mechanisms: A review, Am J Med Technol, 43, 776",{},{"id":26,"text":997,"url":26,"identifiers":998},"Robson, 2001, Wound healing: Biologic features and approaches to maximize healing trajectories, Curr Probl Surg, 38, 72, 10.1067\u002Fmsg.2001.111167",{"doi":999},"10.1067\u002Fmsg.2001.111167",{"id":26,"text":1001,"url":26,"identifiers":1002},"Velnar, 2009, The wound healing process: An overview of the cellular and molecular mechanisms, J Int Med Res, 37, 1528, 10.1177\u002F147323000903700531",{"doi":1003},"10.1177\u002F147323000903700531",{"id":26,"text":1005,"url":26,"identifiers":1006},"Degreef, 1998, How to heal a wound fast, Dermatol Clin, 16, 365, 10.1016\u002FS0733-8635(05)70019-X",{"doi":1007},"10.1016\u002FS0733-8635(05)70019-X",{"id":26,"text":1009,"url":26,"identifiers":1010},"Hunt, 1988, The physiology of wound healing, Ann Emergency Med, 17, 1265, 10.1016\u002FS0196-0644(88)80351-2",{"doi":1011},"10.1016\u002FS0196-0644(88)80351-2",{"id":26,"text":1013,"url":26,"identifiers":1014},"Ramasastry, 2005, Acute wounds, Clin Plast Surg, 32, 195, 10.1016\u002Fj.cps.2004.12.001",{"doi":1015},"10.1016\u002Fj.cps.2004.12.001",{"id":26,"text":1017,"url":26,"identifiers":1018},"Diegelmann, 2004, Wound healing: An overview of acute, fibrotic and delayed healing, Front Biosci, 9, 283, 10.2741\u002F1184",{"doi":1019},"10.2741\u002F1184",{"id":26,"text":1021,"url":26,"identifiers":1022},"Schultz, 1991, EGF and TGF-alpha in wound healing and repair, J Cell Biochem, 45, 346, 10.1002\u002Fjcb.240450407",{"doi":1023},"10.1002\u002Fjcb.240450407",{"id":26,"text":1025,"url":26,"identifiers":1026},"Tonnesen, 2000, Angiogenesis in wound healing, J Invest Dermatol Symp Proc, 5, 40, 10.1046\u002Fj.1087-0024.2000.00014.x",{"doi":1027},"10.1046\u002Fj.1087-0024.2000.00014.x",{"id":26,"text":1029,"url":26,"identifiers":1030},"Clark, 2001, Fibrin and wound healing, Ann N Y Acad Sci, 936, 355, 10.1111\u002Fj.1749-6632.2001.tb03522.x",{"doi":1031},"10.1111\u002Fj.1749-6632.2001.tb03522.x",{"id":26,"text":1033,"url":26,"identifiers":1034},"Baum, 2005, Normal cutaneous wound healing: Clinical correlation with cellular and molecular events, Dermatol Surg, 31, 674, 10.1097\u002F00042728-200506000-00011",{"doi":1035},"10.1097\u002F00042728-200506000-00011",{"id":26,"text":1037,"url":26,"identifiers":1038},"Mulder, 2002, Cellular senescence and matrix metalloproteinase activity in chronic wounds. Relevance to debridement and new technologies, J Am Podiatr Med Assoc, 92, 34, 10.7547\u002F87507315-92-1-34",{"doi":1039},"10.7547\u002F87507315-92-1-34",{"id":26,"text":1041,"url":26,"identifiers":1042},"Clark, 1993, Regulation of Fibroplasia in Cutaneous Wound Repair, Am J Med Sci, 306, 42, 10.1097\u002F00000441-199307000-00011",{"doi":1043},"10.1097\u002F00000441-199307000-00011",{"id":26,"text":1045,"url":26,"identifiers":1046},"Nwomeh, 1999, MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers, J Surg Res, 81, 189, 10.1006\u002Fjsre.1998.5495",{"doi":1047},"10.1006\u002Fjsre.1998.5495",{"id":26,"text":1049,"url":26,"identifiers":1050},"Yager, 1996, Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids, J Invest Dermatol, 107, 743, 10.1111\u002F1523-1747.ep12365637",{"doi":1051},"10.1111\u002F1523-1747.ep12365637",{"id":26,"text":1053,"url":26,"identifiers":1054},"Aggarwal, 2005, Human mesenchymal stem cells modulate allogeneic immune cell responses, Blood, 105, 1815, 10.1182\u002Fblood-2004-04-1559",{"doi":1055},"10.1182\u002Fblood-2004-04-1559",{"id":26,"text":1057,"url":26,"identifiers":1058},"Newman, 2009, Treatment of inflammatory diseases with mesenchymal stem cells, Inflamm Allergy Drug Targets, 8, 110, 10.2174\u002F187152809788462635",{"doi":1059},"10.2174\u002F187152809788462635",{"id":26,"text":1061,"url":26,"identifiers":1062},"Singer, 2011, Mesenchymal stem cells: Mechanisms of inflammation, Annu Rev Pathol, 6, 457, 10.1146\u002Fannurev-pathol-011110-130230",{"doi":1063},"10.1146\u002Fannurev-pathol-011110-130230",{"id":26,"text":1065,"url":26,"identifiers":1066},"Krasnodembskaya, 2010, Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37, Stem Cells, 28, 2229, 10.1002\u002Fstem.544",{"doi":1067},"10.1002\u002Fstem.544",{"id":26,"text":1069,"url":26,"identifiers":1070},"Mei, 2010, Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis, Am J Respir Crit Care Med, 182, 1047, 10.1164\u002Frccm.201001-0010OC",{"doi":1071},"10.1164\u002Frccm.201001-0010OC",{"id":26,"text":1073,"url":26,"identifiers":1074},"Gnecchi, 2008, Paracrine mechanisms in adult stem cell signaling and therapy, Circ Res, 103, 1204, 10.1161\u002FCIRCRESAHA.108.176826",{"doi":1075},"10.1161\u002FCIRCRESAHA.108.176826",{"id":26,"text":1077,"url":26,"identifiers":1078},"Chen, 2008, Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing, PLoS One, 3, e1886, 10.1371\u002Fjournal.pone.0001886",{"doi":1079},"10.1371\u002Fjournal.pone.0001886",{"id":26,"text":1081,"url":26,"identifiers":1082},"Hocking, 2010, Mesenchymal stem cells: Paracrine signaling and differentiation during cutaneous wound repair, Exp Cell Res, 316, 2213, 10.1016\u002Fj.yexcr.2010.05.009",{"doi":1083},"10.1016\u002Fj.yexcr.2010.05.009",{"id":26,"text":1085,"url":26,"identifiers":1086},"Gurtner, 2008, Wound repair and regeneration, Nature, 453, 314, 10.1038\u002Fnature07039",{"doi":1087},"10.1038\u002Fnature07039",{"id":26,"text":1089,"url":26,"identifiers":1090},"Smith, 2010, Mesenchymal stem cells induce dermal fibroblast responses to injury, Exp Cell Res, 316, 48, 10.1016\u002Fj.yexcr.2009.08.001",{"doi":1091},"10.1016\u002Fj.yexcr.2009.08.001",{"id":26,"text":1093,"url":26,"identifiers":1094},"Lee, 2009, Hypoxia-enhanced wound-healing function of adipose-derived stem cells: Increase in stem cell proliferation and up-regulation of VEGF and bFGF, Wound Repair Regen, 17, 540, 10.1111\u002Fj.1524-475X.2009.00499.x",{"doi":1095},"10.1111\u002Fj.1524-475X.2009.00499.x",{"id":26,"text":1097,"url":26,"identifiers":1098},"Ono, 2004, Combined administration of basic fibroblast growth factor protein and the hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds, Wound Repair Regen, 12, 67, 10.1111\u002Fj.1067-1927.2004.012113.x-1",{"doi":1099},"10.1111\u002Fj.1067-1927.2004.012113.x-1",{"id":26,"text":1101,"url":26,"identifiers":1102},"Shah, 1995, Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring, J Cell Sci, 108, 985, 10.1242\u002Fjcs.108.3.985",{"doi":1103},"10.1242\u002Fjcs.108.3.985",{"id":26,"text":1105,"url":26,"identifiers":1106},"Colwell, 2005, Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair, Plast Reconstr Surg, 115, 204, 10.1097\u002F01.PRS.0000138252.51581.22",{"doi":1107},"10.1097\u002F01.PRS.0000138252.51581.22",{"id":26,"text":1109,"url":26,"identifiers":1110},"Cha, 2007, Stem cells in cutaneous wound healing, Clin Dermatol, 25, 73, 10.1016\u002Fj.clindermatol.2006.10.002",{"doi":1111},"10.1016\u002Fj.clindermatol.2006.10.002",{"id":26,"text":1113,"url":26,"identifiers":1114},"Lau, 2009, Exploring the role of stem cells in cutaneous wound healing, Exp Dermatol, 18, 921, 10.1111\u002Fj.1600-0625.2009.00942.x",{"doi":1115},"10.1111\u002Fj.1600-0625.2009.00942.x",{"id":26,"text":1117,"url":26,"identifiers":1118},"Nakagawa, 2005, Human mesenchymal stem cells successfully improve skin-substitute wound healing, Br J Dermatol, 153, 29, 10.1111\u002Fj.1365-2133.2005.06554.x",{"doi":1119},"10.1111\u002Fj.1365-2133.2005.06554.x",{"id":26,"text":1121,"url":26,"identifiers":1122},"Shumakov, 2003, Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts, Bull Exp Biol Med, 136, 192, 10.1023\u002FA:1026387411627",{"doi":1123},"10.1023\u002FA:1026387411627",{"id":26,"text":1125,"url":26,"identifiers":1126},"Badiavas, 2003, Treatment of chronic wounds with bone marrow-derived cells, Arch Dermatol, 139, 510, 10.1001\u002Farchderm.139.4.510",{"doi":1127},"10.1001\u002Farchderm.139.4.510",{"id":26,"text":1129,"url":26,"identifiers":1130},"Vojtassák, 2006, Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot, Neuro Endocrinol Lett, 27, 134",{},{"id":26,"text":1132,"url":26,"identifiers":1133},"Falanga, 2007, Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds, Tissue Eng, 13, 1299, 10.1089\u002Ften.2006.0278",{"doi":1134},"10.1089\u002Ften.2006.0278",{"id":26,"text":1136,"url":26,"identifiers":1137},"Yoshikawa, 2008, Wound therapy by marrow mesenchymal cell transplantation, Plast Reconstr Surg, 121, 860, 10.1097\u002F01.prs.0000299922.96006.24",{"doi":1138},"10.1097\u002F01.prs.0000299922.96006.24",{"id":26,"text":1140,"url":26,"identifiers":1141},"Dash, 2009, Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells, Rejuvenation Res, 12, 359, 10.1089\u002Frej.2009.0872",{"doi":1142},"10.1089\u002Frej.2009.0872",{"id":26,"text":1144,"url":26,"identifiers":1145},"Lu, 2011, Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: A double-blind, randomized, controlled trial, Diabetes Res Clin Pract, 92, 26, 10.1016\u002Fj.diabres.2010.12.010",{"doi":1146},"10.1016\u002Fj.diabres.2010.12.010",{"id":26,"text":1148,"url":26,"identifiers":1149},"Kesting, 2008, Cryopreserved human amniotic membrane for soft tissue repair in rats, Ann Plast Surg, 60, 684, 10.1097\u002FSAP.0b013e31814fb9d2",{"doi":1150},"10.1097\u002FSAP.0b013e31814fb9d2",{"id":26,"text":1152,"url":26,"identifiers":1153},"Kesting, 2008, The role of allogenic amniotic membrane in burn treatment, J Burn Care Res, 29, 907, 10.1097\u002FBCR.0b013e31818b9e40",{"doi":1154},"10.1097\u002FBCR.0b013e31818b9e40",{"id":26,"text":1156,"url":26,"identifiers":1157},"Davis, 1910, Skin transplantation with a review of 550 cases at the Johns Hopkins Hospital, Johns Hopkins Med J, 15, 307",{},{"id":26,"text":1159,"url":26,"identifiers":1160},"Sabella, 1913, Use of fetal membranes in skin grafting, Med Rec, NY, 83, 478",{},{"id":26,"text":1162,"url":26,"identifiers":1163},"Stern, 1913, The grafting of preserved amniotic membrane to burned and ulcerated skin surfaces substituting skin grafts, JAMA, 60, 973, 10.1001\u002Fjama.1913.04340130021008",{"doi":1164},"10.1001\u002Fjama.1913.04340130021008",{"id":26,"text":1166,"url":26,"identifiers":1167},"Toda, 2007, The potential of amniotic membrane\u002Famnion-derived cells for regeneration of various tissues, J Pharmacol Sci, 105, 215, 10.1254\u002Fjphs.CR0070034",{"doi":1168},"10.1254\u002Fjphs.CR0070034",{"id":26,"text":1170,"url":26,"identifiers":1171},"Miki, 2006, Amnion-derived pluripotent\u002Fmultipotent stem cells, Stem Cell Rev, 2, 133, 10.1007\u002Fs12015-006-0020-0",{"doi":1172},"10.1007\u002Fs12015-006-0020-0",{"id":26,"text":1174,"url":26,"identifiers":1175},"Miki, 2007, Identification of stem cell marker-positive cells by immunofluorescence in term human amnion, J Reprod Immunol, 75, 91, 10.1016\u002Fj.jri.2007.03.017",{"doi":1176},"10.1016\u002Fj.jri.2007.03.017",{"id":26,"text":1178,"url":26,"identifiers":1179},"Miki, 2007, Isolation of amniotic epithelial stem cells, Curr Protoc Stem Cell Biol, 10.1002\u002F9780470151808.sc01e03s3",{"doi":1180},"10.1002\u002F9780470151808.sc01e03s3",{"id":26,"text":1182,"url":26,"identifiers":1183},"Koizumi, 2000, Growth factor mRNA and protein in preserved human amniotic membrane, Curr Eye Res, 20, 173, 10.1076\u002F0271-3683(200003)2031-9FT173",{"doi":1184},"10.1076\u002F0271-3683(200003)2031-9FT173",{"id":26,"text":1186,"url":26,"identifiers":1187},"Mermet, 2007, Use of amniotic membrane transplantation in the treatment of venous leg ulcers, Wound Repair Regen, 15, 459, 10.1111\u002Fj.1524-475X.2007.00252.x",{"doi":1188},"10.1111\u002Fj.1524-475X.2007.00252.x",{"id":26,"text":1190,"url":26,"identifiers":1191},"Yoo, 2011, Characterization of novel human mesenchymal stem cell-containing skin substitutes for the treatment of wounds, Ostomy Wound Manage, 57, 71",{},{"id":26,"text":1193,"url":26,"identifiers":1194},"Bieback, 2010, Mesenchymal stromal cells from human perinatal tissues: From biology to cell therapy, World J Stem Cells, 2, 81, 10.4252\u002Fwjsc.v2.i4.81",{"doi":1195},"10.4252\u002Fwjsc.v2.i4.81",{"id":26,"text":1197,"url":26,"identifiers":1198},"Yew, 2011, Enhancement of wound healing by human multipotent stromal cell conditioned medium: The paracrine factors and p38MAPK activation, Cell Transplant, 20, 693, 10.3727\u002F096368910X550198",{"doi":1199},"10.3727\u002F096368910X550198",{"id":26,"text":1201,"url":26,"identifiers":1202},"Wolbank, 2009, Impact of human amniotic membrane preparation on release of angiogenic factors, J Tissue Eng Regen Med, 3, 651, 10.1002\u002Fterm.207",{"doi":1203},"10.1002\u002Fterm.207",{"id":26,"text":777,"url":26,"identifiers":1205},{},{"id":26,"text":1207,"url":26,"identifiers":1208},"Andree, 1994, In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair, Proc Natl Acad Sci U S A, 91, 12188, 10.1073\u002Fpnas.91.25.12188",{"doi":1209},"10.1073\u002Fpnas.91.25.12188",false,{"id":1212,"createTime":1213,"updateTime":1214,"relativeEntities":1215,"slug":1216,"properties":1217,"entityType":792,"verifyStatus":25,"verifyTime":1236,"verifyNote":793,"syncStatus":28,"languages":1237,"translateLanguages":1238,"viewCount":36,"primaryUrl":1239,"fullTextUrl":26,"authors":1240,"publicationType":877,"publisherRelationship":1433,"citationCount":1466,"citationInfo":1467,"publishDate":1471,"publishYear":1472,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1473,"isForceReanalyzing":1210},"a284595a-2f89-4f71-8946-9b0a82008ac2","2024-10-01T09:55:50.485+00:00","2024-12-25T09:02:23.139+00:00",[],"Extracellular-Vesicles-Improve-Post-Stroke-Neuroregeneration-and-Prevent-Postischemic-Immunosuppression",{"mag":1218,"keywords":1220,"pmc":1222,"openalex":1224,"abstract":1226,"title":1229,"pm":1232,"doi":1234},{"VOID":1219},"2177788064",{"VI":1221},"EVs, tế bào gốc trung mô, thiếu máu cục bộ, tái sinh thần kinh, bảo vệ thần kinh, miễn dịch học, đột quỵ, exosomes, tái cấu trúc não, tổn thương não",{"VOID":1223},"4572905",{"VOID":1225},"W2177788064",{"EN":1227,"VI":1228},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:sec>\n                  \u003Cjats:title \u002F>\n                  \u003Cjats:p>Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent evidence has suggested that stem and progenitor cells alike promote postischemic neurological recovery by secreted factors that restore the injured brain's capacity to reshape. Specifically, extracellular vesicles (EVs) derived from stem cells such as exosomes have recently been suggested to mediate restorative stem cell effects. In order to define whether EVs indeed improve postischemic neurological impairment and brain remodeling, we systematically compared the effects of mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) with MSCs that were i.v. delivered to mice on days 1, 3, and 5 (MSC-EVs) or on day 1 (MSCs) after focal cerebral ischemia in C57BL6 mice. For as long as 28 days after stroke, motor coordination deficits, histological brain injury, immune responses in the peripheral blood and brain, and cerebral angiogenesis and neurogenesis were analyzed. Improved neurological impairment and long-term neuroprotection associated with enhanced angioneurogenesis were noticed in stroke mice receiving EVs from two different bone marrow-derived MSC lineages. MSC-EV administration closely resembled responses to MSCs and persisted throughout the observation period. Although cerebral immune cell infiltration was not affected by MSC-EVs, postischemic immunosuppression (i.e., B-cell, natural killer cell, and T-cell lymphopenia) was attenuated in the peripheral blood at 6 days after ischemia, providing an appropriate external milieu for successful brain remodeling. Because MSC-EVs have recently been shown to be apparently safe in humans, the present study provides clinically relevant evidence warranting rapid proof-of-concept studies in stroke patients.\u003C\u002Fjats:p>\n               \u003C\u002Fjats:sec>\n               \u003Cjats:sec>\n                  \u003Cjats:title>Significance\u003C\u002Fjats:title>\n                  \u003Cjats:p>Transplantation of mesenchymal stem cells (MSCs) offers an interesting adjuvant approach next to thrombolysis for treatment of ischemic stroke. However, MSCs are not integrated into residing neural networks but act indirectly, inducing neuroprotection and promoting neuroregeneration. Although the mechanisms by which MSCs act are still elusive, recent evidence has suggested that extracellular vesicles (EVs) might be responsible for MSC-induced effects under physiological and pathological conditions. The present study has demonstrated that EVs are not inferior to MSCs in a rodent stroke model. EVs induce long-term neuroprotection, promote neuroregeneration and neurological recovery, and modulate peripheral post-stroke immune responses. Also, because EVs are well-tolerated in humans, as previously reported, the administration of EVs under clinical settings might set the path for a novel and innovative therapeutic stroke concept without the putative side effects attached to stem cell transplantation.\u003C\u002Fjats:p>\n               \u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n               \u003Cjats:sec>\n                  \u003Cjats:title \u002F>\n                  \u003Cjats:p>Mặc dù các khái niệm ban đầu về liệu pháp tế bào gốc nhằm thay thế mô bị mất, nhưng bằng chứng gần đây đã gợi ý rằng cả tế bào gốc và tiền thân đều thúc đẩy phục hồi thần kinh sau thiếu máu cục bộ thông qua các yếu tố tiết ra giúp phục hồi khả năng tái cấu trúc của não bị tổn thương. Cụ thể, các túi ngoại tiết (EVs) từ các tế bào gốc như exosomes đã được đề xuất gần đây có vai trò trung gian cho các tác dụng phục hồi của tế bào gốc. Để xác định liệu EVs có thực sự cải thiện suy giảm thần kinh sau thiếu máu cục bộ và tái cấu trúc não hay không, chúng tôi đã so sánh có hệ thống các tác động của các túi ngoại tiết (MSC-EVs) từ tế bào gốc trung mô (MSCs) so với MSCs được truyền i.v. vào chuột trong các ngày 1, 3 và 5 (MSC-EVs) hoặc ngày 1 (MSCs) sau khi xảy ra thiếu máu cục bộ não tiêu điểm ở chuột C57BL6. Trong 28 ngày sau khi đột quỵ, các điểm yếu về phối hợp vận động, tổn thương não trên mô học, phản ứng miễn dịch trong máu ngoại vi và não, cùng những thay đổi về tạo mạch và sinh trưởng tâm thần kinh đã được phân tích. Cải thiện suy giảm thần kinh và bảo vệ thần kinh dài hạn kết hợp với tăng cường tạo mạch thần kinh và thần kinh đã được ghi nhận ở các con chuột bị đột quỵ nhận EVs từ hai dòng MSC nguồn gốc tủy xương khác nhau. Việc sử dụng MSC-EV mô phỏng chính xác các phản ứng của MSCs và kéo dài suốt giai đoạn quan sát. Mặc dù sự xâm nhập của tế bào miễn dịch não không bị ảnh hưởng bởi MSC-EVs, sự suy giảm miễn dịch sau thiếu máu cục bộ (tức là B-cell, tế bào giết tự nhiên và lymphopenia tế bào T) đã giảm bớt trong máu ngoại vi ở 6 ngày sau thiếu máu cục bộ, cung cấp môi trường ngoại vi thích hợp cho tái cấu trúc não thành công. Vì các nghiên cứu gần đây cho thấy MSC-EVs an toàn với con người, nghiên cứu này cung cấp bằng chứng lâm sàng quan trọng cần thiết cho các nghiên cứu chứng minh nhanh chóng trong bệnh nhân đột quỵ.\u003C\u002Fjats:p>\n               \u003C\u002Fjats:sec>\n               \u003Cjats:sec>\n                  \u003Cjats:title>Ý nghĩa\u003C\u002Fjats:title>\n                  \u003Cjats:p>Cấy ghép các tế bào gốc trung mô (MSCs) cung cấp một phương pháp tiếp cận hỗ trợ quan trọng bên cạnh việc làm tan cục máu đông để điều trị đột quỵ thiếu máu cục bộ. Tuy nhiên, MSCs không tích hợp vào các mạng lưới thần kinh cư trú mà hoạt động gián tiếp, gây bảo vệ thần kinh và thúc đẩy tái sinh thần kinh. Mặc dù cơ chế MSCs hoạt động còn chưa rõ ràng, bằng chứng gần đây đã gợi ý rằng các túi ngoại tiết (EVs) có thể chịu trách nhiệm cho các tác dụng gây ra bởi MSCs dưới điều kiện sinh lý và bệnh lý. Nghiên cứu hiện tại đã chứng minh rằng EVs không thua kém MSCs trong mô hình đột quỵ động vật gặm nhấm. EVs gây bảo vệ thần kinh lâu dài, thúc đẩy tái sinh thần kinh và phục hồi chức năng thần kinh, và điều tiết các phản ứng miễn dịch sau đột quỵ ngoại biên. Ngoài ra, vì EVs dung nạp tốt ở người theo báo cáo trước đó, việc sử dụng EVs trong điều kiện lâm sàng có thể mở đường cho một định nghĩa điều trị đột quỵ mới và sáng tạo mà không có các tác dụng phụ dự kiến liên quan đến cấy ghép tế bào gốc.\u003C\u002Fjats:p>\n               \u003C\u002Fjats:sec>",{"EN":1230,"VI":1231},"Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression","Các túi ngoại tiết cải thiện tái sinh thần kinh sau đột quỵ và ngăn ngừa suy giảm miễn dịch sau thiếu máu cục bộ",{"VOID":1233},"26339036",{"VOID":1235},"10.5966\u002Fsctm.2015-0078","2024-10-01T09:55:50.484+00:00",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F4\u002F10\u002F1131-1143\u002F6387853",[1241,1263,1295,1310,1327,1342,1365,1382,1399,1416],{"id":1242,"sortIndex":162,"researcher":26,"roles":1243,"affiliations":1244,"properties":1256},"a99a7aa7-a62d-4eda-ad3b-27baf44a8614",[],[1245],{"id":1246,"sortIndex":36,"affiliation":1247,"properties":26},"18d867e8-b47c-4a04-8e5d-8a017b714f9d",{"id":1248,"createTime":1249,"updateTime":1250,"relativeEntities":1251,"slug":1252,"properties":1253,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"718b55d7-5b76-4baa-a07d-3e2675c04383","2024-01-10T04:02:51.931+00:00","2024-10-01T09:55:50.507+00:00",[],"Institute-for-Transfusion-Medicine-University-Hospital-Essen-University-of-Duisburg-Essen-Essen-Germany",{"title":1254},{"VI":1255},"Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany",{"openalex":1257,"orcid":1259,"title":1261},{"VOID":1258},"A5047833836",{"VOID":1260},"https:\u002F\u002Forcid.org\u002F0000-0002-2842-4820",{"EN":1262},"Stefan Radtke",{"id":1264,"sortIndex":115,"researcher":26,"roles":1265,"affiliations":1266,"properties":1288},"5016a061-244d-49bd-aed1-c20da172e80f",[],[1267,1277],{"id":1268,"sortIndex":115,"affiliation":1269,"properties":26},"0a2d5884-81ef-4a9e-b740-9f4bb042134a",{"id":1270,"createTime":1271,"updateTime":1271,"relativeEntities":1272,"slug":1273,"properties":1274,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"bb0d6c8e-3d67-4298-b986-8275606203fc","2024-10-01T09:55:50.518+00:00",[],"Department-of-Pediatrics-I-University-Hospital-Essen-University-of-Duisburg-Essen-Essen-Germany",{"title":1275},{"EN":1276},"Department of Pediatrics I, University Hospital Essen, University of Duisburg-Essen, Essen, Germany",{"id":1278,"sortIndex":36,"affiliation":1279,"properties":26},"186a7505-825d-4dbb-9216-120e125a4d1d",{"id":1280,"createTime":1281,"updateTime":1282,"relativeEntities":1283,"slug":1284,"properties":1285,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"021f8cea-93cb-4324-9109-77d128e184dd","2024-04-21T20:49:56.255+00:00","2025-06-11T15:33:06.124+00:00",[],"Department-of-Neurology-University-Hospital-Essen-University-of-Duisburg-Essen-Essen-Germany",{"title":1286},{"EN":1287},"Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany",{"openalex":1289,"orcid":1291,"title":1293},{"VOID":1290},"A5016898105",{"VOID":1292},"https:\u002F\u002Forcid.org\u002F0000-0001-8132-7459",{"EN":1294},"Josephine Herz",{"id":1296,"sortIndex":59,"researcher":26,"roles":1297,"affiliations":1298,"properties":1305},"8f874e7b-da29-4ee5-a3a1-f44482bbcf48",[],[1299],{"id":1300,"sortIndex":36,"affiliation":1301,"properties":26},"83560158-f8c3-4640-bd36-fa10427984cd",{"id":1280,"createTime":1281,"updateTime":1282,"relativeEntities":1302,"slug":1284,"properties":1303,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1304},{"EN":1287},{"openalex":1306,"title":1308},{"VOID":1307},"A5054870694",{"EN":1309},"Jana Schlechter",{"id":1311,"sortIndex":50,"researcher":26,"roles":1312,"affiliations":1313,"properties":1320},"905d8660-0f01-43bf-90bf-5b5589884df4",[],[1314],{"id":1315,"sortIndex":36,"affiliation":1316,"properties":26},"c90bcfe6-9ad2-43fe-ac93-9e44c266f470",{"id":1248,"createTime":1249,"updateTime":1250,"relativeEntities":1317,"slug":1252,"properties":1318,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1319},{"VI":1255},{"openalex":1321,"orcid":1323,"title":1325},{"VOID":1322},"A5031009228",{"VOID":1324},"https:\u002F\u002Forcid.org\u002F0000-0003-2446-948X",{"EN":1326},"Bernd Giebel",{"id":1328,"sortIndex":135,"researcher":26,"roles":1329,"affiliations":1330,"properties":1337},"2faf0a91-3687-43f8-9301-c67f3ba40e55",[],[1331],{"id":1332,"sortIndex":36,"affiliation":1333,"properties":26},"f2b0dba5-bded-46f7-b995-b735358ffd03",{"id":1248,"createTime":1249,"updateTime":1250,"relativeEntities":1334,"slug":1252,"properties":1335,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1336},{"VI":1255},{"openalex":1338,"title":1340},{"VOID":1339},"A5007507729",{"EN":1341},"Kyra de Miroschedji",{"id":1343,"sortIndex":36,"researcher":26,"roles":1344,"affiliations":1345,"properties":1358},"4f8c3854-63d8-4426-b10c-6183a51caa84",[],[1346,1352],{"id":1347,"sortIndex":36,"affiliation":1348,"properties":26},"83cfef01-201d-459b-8e28-f7fbd00ae4bf",{"id":1280,"createTime":1281,"updateTime":1282,"relativeEntities":1349,"slug":1284,"properties":1350,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1351},{"EN":1287},{"id":1353,"sortIndex":115,"affiliation":1354,"properties":26},"0482ba85-d777-491c-8411-fedc7edc7f74",{"id":1248,"createTime":1249,"updateTime":1250,"relativeEntities":1355,"slug":1252,"properties":1356,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1357},{"VI":1255},{"openalex":1359,"orcid":1361,"title":1363},{"VOID":1360},"A5057081490",{"VOID":1362},"https:\u002F\u002Forcid.org\u002F0000-0002-1222-9211",{"EN":1364},"Thorsten R. Doeppner",{"id":1366,"sortIndex":158,"researcher":26,"roles":1367,"affiliations":1368,"properties":1375},"1dfa8474-9517-4c83-b1c1-ec9c69628e1e",[],[1369],{"id":1370,"sortIndex":36,"affiliation":1371,"properties":26},"232c67a5-d752-41e7-8ea5-f1c60f8444a7",{"id":1248,"createTime":1249,"updateTime":1250,"relativeEntities":1372,"slug":1252,"properties":1373,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1374},{"VI":1255},{"openalex":1376,"orcid":1378,"title":1380},{"VOID":1377},"A5027480329",{"VOID":1379},"https:\u002F\u002Forcid.org\u002F0000-0003-0901-3484",{"EN":1381},"Peter A. Horn",{"id":1383,"sortIndex":114,"researcher":26,"roles":1384,"affiliations":1385,"properties":1392},"003e8f36-a607-420e-833a-282891c46d47",[],[1386],{"id":1387,"sortIndex":36,"affiliation":1388,"properties":26},"f399dcdf-8b5a-488a-b3d1-bd82352fe62a",{"id":1248,"createTime":1249,"updateTime":1250,"relativeEntities":1389,"slug":1252,"properties":1390,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1391},{"VI":1255},{"openalex":1393,"orcid":1395,"title":1397},{"VOID":1394},"A5011018836",{"VOID":1396},"https:\u002F\u002Forcid.org\u002F0000-0001-9198-0857",{"EN":1398},"André Görgens",{"id":1400,"sortIndex":111,"researcher":26,"roles":1401,"affiliations":1402,"properties":1409},"0c9465d2-0fb4-43a2-8d19-fee8bf902c31",[],[1403],{"id":1404,"sortIndex":36,"affiliation":1405,"properties":26},"5532d749-4d45-4428-b239-491601600568",{"id":1248,"createTime":1249,"updateTime":1250,"relativeEntities":1406,"slug":1252,"properties":1407,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1408},{"VI":1255},{"openalex":1410,"orcid":1412,"title":1414},{"VOID":1411},"A5024500046",{"VOID":1413},"https:\u002F\u002Forcid.org\u002F0000-0003-0901-839X",{"EN":1415},"Anna‐Kristin Ludwig",{"id":1417,"sortIndex":52,"researcher":26,"roles":1418,"affiliations":1419,"properties":1426},"a5509fc2-566f-4c08-8286-dcba90af84d0",[],[1420],{"id":1421,"sortIndex":36,"affiliation":1422,"properties":26},"a5f0e964-8d4c-4ba1-a0b3-9a55174892ca",{"id":1280,"createTime":1281,"updateTime":1282,"relativeEntities":1423,"slug":1284,"properties":1424,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1425},{"EN":1287},{"openalex":1427,"orcid":1429,"title":1431},{"VOID":1428},"A5028410367",{"VOID":1430},"https:\u002F\u002Forcid.org\u002F0000-0003-0198-3152",{"EN":1432},"Dirk M. Hermann",{"url":26,"publisher":1434,"properties":1459},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1435,"slug":663,"properties":1436,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1442,"manageAffiliations":1443,"indexDatabases":1444,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":1437,"issn":1438,"introduce":1439,"eissn":1440,"title":1441},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[1445,1452],{"id":742,"indexDatabase":1446,"url":755,"indexYears":756,"academicFieldIds":1451,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":1447,"label":1448,"description":1449,"key":752,"publicationTags":1450,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":1453,"url":738,"indexYears":26,"academicFieldIds":1458,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":1454,"label":1455,"description":1456,"key":734,"publicationTags":1457,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":1460,"pages":1462,"issue":1464},{"VOID":1461},"4",{"VOID":1463},"1131-1143",{"VOID":1465},"10",643,{"total":1466,"publishYear":26,"statisticByYear":1468},{"2015":114,"2016":241,"2017":48,"2018":250,"2019":249,"2020":1469,"2021":1470,"2022":251,"2023":353,"2024":29},98,105,"2015-10-01",2015,[1474,1478,1482,1486,1490,1494,1498,1502,1506,1510,1514,1518,1522,1526,1530,1534,1538,1542,1546,1550,1554,1558,1562,1566,1570,1574,1578,1582,1586,1590,1594,1598,1602,1606,1609,1613,1617,1621,1625,1629,1633,1637,1641,1645,1649,1653,1657,1661,1665,1669,1673,1677,1681,1685,1689,1693,1697,1701,1705,1708,1712,1716,1720,1724,1728,1732,1735,1739,1743,1747],{"id":26,"text":1475,"url":26,"identifiers":1476},"Bacigaluppi, 2009, Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms, Brain, 132, 2239, 10.1093\u002Fbrain\u002Fawp174",{"doi":1477},"10.1093\u002Fbrain\u002Fawp174",{"id":26,"text":1479,"url":26,"identifiers":1480},"Banerjee, 2012, The potential benefit of stem cell therapy after stroke: An update, Vasc Health Risk Manag, 8, 569, 10.2147\u002FVHRM.S25745",{"doi":1481},"10.2147\u002FVHRM.S25745",{"id":26,"text":1483,"url":26,"identifiers":1484},"Chen, 2001, Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats, Stroke, 32, 1005, 10.1161\u002F01.STR.32.4.1005",{"doi":1485},"10.1161\u002F01.STR.32.4.1005",{"id":26,"text":1487,"url":26,"identifiers":1488},"Dharmasaroja, 2009, Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke, J Clin Neurosci, 16, 12, 10.1016\u002Fj.jocn.2008.05.006",{"doi":1489},"10.1016\u002Fj.jocn.2008.05.006",{"id":26,"text":1491,"url":26,"identifiers":1492},"Doeppner, 2014, Effects of acute versus post-acute systemic delivery of neural progenitor cells on neurological recovery and brain remodeling after focal cerebral ischemia in mice, Cell Death Dis, 5, e1386, 10.1038\u002Fcddis.2014.359",{"doi":1493},"10.1038\u002Fcddis.2014.359",{"id":26,"text":1495,"url":26,"identifiers":1496},"Leong, 2012, Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms, Stem Cells Translational Medicine, 1, 177, 10.5966\u002Fsctm.2011-0039",{"doi":1497},"10.5966\u002Fsctm.2011-0039",{"id":26,"text":1499,"url":26,"identifiers":1500},"Schwarting, 2008, Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury, Stroke, 39, 2867, 10.1161\u002FSTROKEAHA.108.513978",{"doi":1501},"10.1161\u002FSTROKEAHA.108.513978",{"id":26,"text":1503,"url":26,"identifiers":1504},"Shen, 2007, One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke, Stroke, 38, 2150, 10.1161\u002FSTROKEAHA.106.481218",{"doi":1505},"10.1161\u002FSTROKEAHA.106.481218",{"id":26,"text":1507,"url":26,"identifiers":1508},"Shen, 2007, Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke, J Cereb Blood Flow Metab, 27, 6, 10.1038\u002Fsj.jcbfm.9600311",{"doi":1509},"10.1038\u002Fsj.jcbfm.9600311",{"id":26,"text":1511,"url":26,"identifiers":1512},"Shen, 2006, Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke, Neuroscience, 137, 393, 10.1016\u002Fj.neuroscience.2005.08.092",{"doi":1513},"10.1016\u002Fj.neuroscience.2005.08.092",{"id":26,"text":1515,"url":26,"identifiers":1516},"Ukai, 2007, Mesenchymal stem cells derived from peripheral blood protects against ischemia, J Neurotrauma, 24, 508, 10.1089\u002Fneu.2006.0161",{"doi":1517},"10.1089\u002Fneu.2006.0161",{"id":26,"text":1519,"url":26,"identifiers":1520},"Zheng, 2010, Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia, Brain Res, 1310, 8, 10.1016\u002Fj.brainres.2009.11.012",{"doi":1521},"10.1016\u002Fj.brainres.2009.11.012",{"id":26,"text":1523,"url":26,"identifiers":1524},"Caplan, 2007, Adult mesenchymal stem cells for tissue engineering versus regenerative medicine, J Cell Physiol, 213, 341, 10.1002\u002Fjcp.21200",{"doi":1525},"10.1002\u002Fjcp.21200",{"id":26,"text":1527,"url":26,"identifiers":1528},"Bhasin, 2011, Autologous mesenchymal stem cells in chronic stroke, Cerebrovasc Dis Extra, 1, 93, 10.1159\u002F000333381",{"doi":1529},"10.1159\u002F000333381",{"id":26,"text":1531,"url":26,"identifiers":1532},"Bhasin, 2013, Stem cell therapy: A clinical trial of stroke, Clin Neurol Neurosurg, 115, 1003, 10.1016\u002Fj.clineuro.2012.10.015",{"doi":1533},"10.1016\u002Fj.clineuro.2012.10.015",{"id":26,"text":1535,"url":26,"identifiers":1536},"Doeppner, 2014, Stem cell-based treatments against stroke: Observations from human proof-of-concept studies and considerations regarding clinical applicability, Front Cell Neurosci, 8, 357, 10.3389\u002Ffncel.2014.00357",{"doi":1537},"10.3389\u002Ffncel.2014.00357",{"id":26,"text":1539,"url":26,"identifiers":1540},"Honmou, 2011, Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke, Brain, 134, 1790, 10.1093\u002Fbrain\u002Fawr063",{"doi":1541},"10.1093\u002Fbrain\u002Fawr063",{"id":26,"text":1543,"url":26,"identifiers":1544},"Savitz, 2011, Intravenous autologous bone marrow mononuclear cells for ischemic stroke, Ann Neurol, 70, 59, 10.1002\u002Fana.22458",{"doi":1545},"10.1002\u002Fana.22458",{"id":26,"text":1547,"url":26,"identifiers":1548},"England, 2009, Stem cells for enhancing recovery after stroke: A review, Int J Stroke, 4, 101, 10.1111\u002Fj.1747-4949.2009.00253.x",{"doi":1549},"10.1111\u002Fj.1747-4949.2009.00253.x",{"id":26,"text":1551,"url":26,"identifiers":1552},"Hermann, 2012, Promoting brain remodelling and plasticity for stroke recovery: Therapeutic promise and potential pitfalls of clinical translation, Lancet Neurol, 11, 369, 10.1016\u002FS1474-4422(12)70039-X",{"doi":1553},"10.1016\u002FS1474-4422(12)70039-X",{"id":26,"text":1555,"url":26,"identifiers":1556},"Yoo, 2008, Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model, Exp Mol Med, 40, 387, 10.3858\u002Femm.2008.40.4.387",{"doi":1557},"10.3858\u002Femm.2008.40.4.387",{"id":26,"text":1559,"url":26,"identifiers":1560},"Doeppner, 2012, Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: Therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation, Stem Cells, 30, 1297, 10.1002\u002Fstem.1098",{"doi":1561},"10.1002\u002Fstem.1098",{"id":26,"text":1563,"url":26,"identifiers":1564},"Lee, 2009, Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6, Cell Stem Cell, 5, 54, 10.1016\u002Fj.stem.2009.05.003",{"doi":1565},"10.1016\u002Fj.stem.2009.05.003",{"id":26,"text":1567,"url":26,"identifiers":1568},"Timmers, 2007, Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium, Stem Cell Res (Amst), 1, 129, 10.1016\u002Fj.scr.2008.02.002",{"doi":1569},"10.1016\u002Fj.scr.2008.02.002",{"id":26,"text":1571,"url":26,"identifiers":1572},"Hsieh, 2013, Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis, PLoS One, 8, e72604, 10.1371\u002Fjournal.pone.0072604",{"doi":1573},"10.1371\u002Fjournal.pone.0072604",{"id":26,"text":1575,"url":26,"identifiers":1576},"Scheibe, 2012, Mesenchymal stromal cells rescue cortical neurons from apoptotic cell death in an in vitro model of cerebral ischemia, Cell Mol Neurobiol, 32, 567, 10.1007\u002Fs10571-012-9798-2",{"doi":1577},"10.1007\u002Fs10571-012-9798-2",{"id":26,"text":1579,"url":26,"identifiers":1580},"Tate, 2010, Human mesenchymal stromal cells and their derivative, SB623 cells, rescue neural cells via trophic support following in vitro ischemia, Cell Transplant, 19, 973, 10.3727\u002F096368910X494885",{"doi":1581},"10.3727\u002F096368910X494885",{"id":26,"text":1583,"url":26,"identifiers":1584},"Cantaluppi, 2012, Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells, Kidney Int, 82, 412, 10.1038\u002Fki.2012.105",{"doi":1585},"10.1038\u002Fki.2012.105",{"id":26,"text":1587,"url":26,"identifiers":1588},"Gatti, 2011, Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury, Nephrol Dial Transplant, 26, 1474, 10.1093\u002Fndt\u002Fgfr015",{"doi":1589},"10.1093\u002Fndt\u002Fgfr015",{"id":26,"text":1591,"url":26,"identifiers":1592},"Lai, 2010, Exosome secreted by MSC reduces myocardial ischemia\u002Freperfusion injury, Stem Cell Res (Amst), 4, 214, 10.1016\u002Fj.scr.2009.12.003",{"doi":1593},"10.1016\u002Fj.scr.2009.12.003",{"id":26,"text":1595,"url":26,"identifiers":1596},"Li, 2013, Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis, Stem Cells Dev, 22, 845, 10.1089\u002Fscd.2012.0395",{"doi":1597},"10.1089\u002Fscd.2012.0395",{"id":26,"text":1599,"url":26,"identifiers":1600},"Xin, 2013, Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats, J Cereb Blood Flow Metab, 33, 1711, 10.1038\u002Fjcbfm.2013.152",{"doi":1601},"10.1038\u002Fjcbfm.2013.152",{"id":26,"text":1603,"url":26,"identifiers":1604},"Witwer, 2013, Standardization of sample collection, isolation and analysis methods in extracellular vesicle research, J Extracell Vesicles, 2, 2, 10.3402\u002Fjev.v2i0.20360",{"doi":1605},"10.3402\u002Fjev.v2i0.20360",{"id":26,"text":1607,"url":26,"identifiers":1608},"Thery, 2006, Isolation and characterization of exosomes from cell culture supernatants and biological fluids, Curr Protoc Cell Biol, Chapter 3, Unit 3.22",{},{"id":26,"text":1610,"url":26,"identifiers":1611},"Valadi, 2007, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nat Cell Biol, 9, 654, 10.1038\u002Fncb1596",{"doi":1612},"10.1038\u002Fncb1596",{"id":26,"text":1614,"url":26,"identifiers":1615},"Ludwig, 2012, Exosomes: Small vesicles participating in intercellular communication, Int J Biochem Cell Biol, 44, 11, 10.1016\u002Fj.biocel.2011.10.005",{"doi":1616},"10.1016\u002Fj.biocel.2011.10.005",{"id":26,"text":1618,"url":26,"identifiers":1619},"Mitkari, 2013, Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats, Exp Neurol, 239, 158, 10.1016\u002Fj.expneurol.2012.09.018",{"doi":1620},"10.1016\u002Fj.expneurol.2012.09.018",{"id":26,"text":1622,"url":26,"identifiers":1623},"Janowski, 2013, Cell size and velocity of injection are major determinants of the safety of intracarotid stem cell transplantation, J Cereb Blood Flow Metab, 33, 921, 10.1038\u002Fjcbfm.2013.32",{"doi":1624},"10.1038\u002Fjcbfm.2013.32",{"id":26,"text":1626,"url":26,"identifiers":1627},"Blum, 2008, The tumorigenicity of human embryonic stem cells, Adv Cancer Res, 100, 133, 10.1016\u002FS0065-230X(08)00005-5",{"doi":1628},"10.1016\u002FS0065-230X(08)00005-5",{"id":26,"text":1630,"url":26,"identifiers":1631},"Blum, 2009, The tumorigenicity of diploid and aneuploid human pluripotent stem cells, Cell Cycle, 8, 3822, 10.4161\u002Fcc.8.23.10067",{"doi":1632},"10.4161\u002Fcc.8.23.10067",{"id":26,"text":1634,"url":26,"identifiers":1635},"Dlouhy, 2014, Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: Case report, J Neurosurg Spine, 21, 618, 10.3171\u002F2014.5.SPINE13992",{"doi":1636},"10.3171\u002F2014.5.SPINE13992",{"id":26,"text":1638,"url":26,"identifiers":1639},"Kordelas, 2014, MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease, Leukemia, 28, 970, 10.1038\u002Fleu.2014.41",{"doi":1640},"10.1038\u002Fleu.2014.41",{"id":26,"text":1642,"url":26,"identifiers":1643},"Le Blanc, 2004, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells, Lancet, 363, 1439, 10.1016\u002FS0140-6736(04)16104-7",{"doi":1644},"10.1016\u002FS0140-6736(04)16104-7",{"id":26,"text":1646,"url":26,"identifiers":1647},"Sokolova, 2011, Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy, Colloids Surf B Biointerfaces, 87, 146, 10.1016\u002Fj.colsurfb.2011.05.013",{"doi":1648},"10.1016\u002Fj.colsurfb.2011.05.013",{"id":26,"text":1650,"url":26,"identifiers":1651},"Doeppner, 2014, Effects of neural progenitor cells on post-stroke neurological impairment—A detailed and comprehensive analysis of behavioral tests, Front Cell Neurosci, 8, 338, 10.3389\u002Ffncel.2014.00338",{"doi":1652},"10.3389\u002Ffncel.2014.00338",{"id":26,"text":1654,"url":26,"identifiers":1655},"Lin, 1993, Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats, Stroke, 24, 117, 10.1161\u002F01.STR.24.1.117",{"doi":1656},"10.1161\u002F01.STR.24.1.117",{"id":26,"text":1658,"url":26,"identifiers":1659},"Herz, 2014, Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses, Neurobiol Dis, 62, 456, 10.1016\u002Fj.nbd.2013.10.022",{"doi":1660},"10.1016\u002Fj.nbd.2013.10.022",{"id":26,"text":1662,"url":26,"identifiers":1663},"Macrez, 2011, Stroke and the immune system: From pathophysiology to new therapeutic strategies, Lancet Neurol, 10, 471, 10.1016\u002FS1474-4422(11)70066-7",{"doi":1664},"10.1016\u002FS1474-4422(11)70066-7",{"id":26,"text":1666,"url":26,"identifiers":1667},"Uccelli, 2008, Mesenchymal stem cells in health and disease, Nat Rev Immunol, 8, 726, 10.1038\u002Fnri2395",{"doi":1668},"10.1038\u002Fnri2395",{"id":26,"text":1670,"url":26,"identifiers":1671},"Offner, 2006, Experimental stroke induces massive, rapid activation of the peripheral immune system, J Cereb Blood Flow Metab, 26, 654, 10.1038\u002Fsj.jcbfm.9600217",{"doi":1672},"10.1038\u002Fsj.jcbfm.9600217",{"id":26,"text":1674,"url":26,"identifiers":1675},"Dirnagl, 2007, Stroke-induced immunodepression: Experimental evidence and clinical relevance, Stroke, 38, 770, 10.1161\u002F01.STR.0000251441.89665.bc",{"doi":1676},"10.1161\u002F01.STR.0000251441.89665.bc",{"id":26,"text":1678,"url":26,"identifiers":1679},"Meisel, 2011, Suppressing immunosuppression after stroke, N Engl J Med, 365, 2134, 10.1056\u002FNEJMcibr1112454",{"doi":1680},"10.1056\u002FNEJMcibr1112454",{"id":26,"text":1682,"url":26,"identifiers":1683},"Meisel, 2005, Central nervous system injury-induced immune deficiency syndrome, Nat Rev Neurosci, 6, 775, 10.1038\u002Fnrn1765",{"doi":1684},"10.1038\u002Fnrn1765",{"id":26,"text":1686,"url":26,"identifiers":1687},"Gelderblom, 2009, Temporal and spatial dynamics of cerebral immune cell accumulation in stroke, Stroke, 40, 1849, 10.1161\u002FSTROKEAHA.108.534503",{"doi":1688},"10.1161\u002FSTROKEAHA.108.534503",{"id":26,"text":1690,"url":26,"identifiers":1691},"Chung, 2009, Intraarterially delivered human umbilical cord blood-derived mesenchymal stem cells in canine cerebral ischemia, J Neurosci Res, 87, 3554, 10.1002\u002Fjnr.22162",{"doi":1692},"10.1002\u002Fjnr.22162",{"id":26,"text":1694,"url":26,"identifiers":1695},"Honma, 2006, Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat, Exp Neurol, 199, 56, 10.1016\u002Fj.expneurol.2005.05.004",{"doi":1696},"10.1016\u002Fj.expneurol.2005.05.004",{"id":26,"text":1698,"url":26,"identifiers":1699},"Leu, 2010, Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats, J Transl Med, 8, 63, 10.1186\u002F1479-5876-8-63",{"doi":1700},"10.1186\u002F1479-5876-8-63",{"id":26,"text":1702,"url":26,"identifiers":1703},"Bliss, 2010, Optimizing the success of cell transplantation therapy for stroke, Neurobiol Dis, 37, 275, 10.1016\u002Fj.nbd.2009.10.003",{"doi":1704},"10.1016\u002Fj.nbd.2009.10.003",{"id":26,"text":1706,"url":26,"identifiers":1707},"Doeppner, 2010, Mesenchymal stem cells in the treatment of ischemic stroke: Progress and possibilities, Stem Cells Cloning, 3, 157",{},{"id":26,"text":1709,"url":26,"identifiers":1710},"Onda, 2008, Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia, J Cereb Blood Flow Metab, 28, 329, 10.1038\u002Fsj.jcbfm.9600527",{"doi":1711},"10.1038\u002Fsj.jcbfm.9600527",{"id":26,"text":1713,"url":26,"identifiers":1714},"Doeppner, 2013, MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation, Acta Neuropathol, 126, 251, 10.1007\u002Fs00401-013-1142-5",{"doi":1715},"10.1007\u002Fs00401-013-1142-5",{"id":26,"text":1717,"url":26,"identifiers":1718},"Komatsu, 2010, Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia, Brain Res, 1334, 84, 10.1016\u002Fj.brainres.2010.04.006",{"doi":1719},"10.1016\u002Fj.brainres.2010.04.006",{"id":26,"text":1721,"url":26,"identifiers":1722},"Caplan, 2011, The MSC: An injury drugstore, Cell Stem Cell, 9, 11, 10.1016\u002Fj.stem.2011.06.008",{"doi":1723},"10.1016\u002Fj.stem.2011.06.008",{"id":26,"text":1725,"url":26,"identifiers":1726},"Pittenger, 2009, Sleuthing the source of regeneration by MSCs, Cell Stem Cell, 5, 8, 10.1016\u002Fj.stem.2009.06.013",{"doi":1727},"10.1016\u002Fj.stem.2009.06.013",{"id":26,"text":1729,"url":26,"identifiers":1730},"van Koppen, 2012, Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease, PLoS One, 7, e38746, 10.1371\u002Fjournal.pone.0038746",{"doi":1731},"10.1371\u002Fjournal.pone.0038746",{"id":26,"text":1733,"url":26,"identifiers":1734},"Famakin, 2014, The immune response to acute focal cerebral ischemia and associated post-stroke immunodepression: A focused review, Aging Dis, 5, 307",{},{"id":26,"text":1736,"url":26,"identifiers":1737},"Vogelgesang, 2010, Functional status of peripheral blood T-cells in ischemic stroke patients, PLoS One, 5, e8718, 10.1371\u002Fjournal.pone.0008718",{"doi":1738},"10.1371\u002Fjournal.pone.0008718",{"id":26,"text":1740,"url":26,"identifiers":1741},"Sheikh, 2011, Mesenchymal stem cell transplantation modulates neuroinflammation in focal cerebral ischemia: Contribution of fractalkine and IL-5, Neurobiol Dis, 41, 717, 10.1016\u002Fj.nbd.2010.12.009",{"doi":1742},"10.1016\u002Fj.nbd.2010.12.009",{"id":26,"text":1744,"url":26,"identifiers":1745},"Yoo, 2013, Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β, Neurobiol Dis, 58, 249, 10.1016\u002Fj.nbd.2013.06.001",{"doi":1746},"10.1016\u002Fj.nbd.2013.06.001",{"id":26,"text":1748,"url":26,"identifiers":1749},"Li, 2012, Mesenchymal stem cells: A double-edged sword in regulating immune responses, Cell Death Differ, 19, 1505, 10.1038\u002Fcdd.2012.26",{"doi":1750},"10.1038\u002Fcdd.2012.26",{"id":1752,"createTime":1753,"updateTime":1754,"relativeEntities":1755,"slug":1756,"properties":1757,"entityType":792,"verifyStatus":25,"verifyTime":1775,"verifyNote":793,"syncStatus":28,"languages":1776,"translateLanguages":1777,"viewCount":36,"primaryUrl":1778,"fullTextUrl":26,"authors":1779,"publicationType":877,"publisherRelationship":1926,"citationCount":1959,"citationInfo":1960,"publishDate":1965,"publishYear":1966,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1967,"isForceReanalyzing":1210},"1a2bd9e9-b3a5-424c-b525-2da02d823c98","2024-10-03T05:20:14.425+00:00","2025-02-22T15:11:54.619+00:00",[],"Concise-Review-Multifaceted-Characterization-of-Human-Mesenchymal-Stem-Cells-for-Use-in-Regenerative-Medicine",{"mag":1758,"keywords":1760,"pmc":1761,"openalex":1763,"abstract":1765,"title":1768,"pm":1771,"doi":1773},{"VOID":1759},"2765979567",{"VI":777},{"VOID":1762},"5702523",{"VOID":1764},"W2765979567",{"EN":1766,"VI":1767},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Mesenchymal stem cells (MSC) hold great potential for regenerative medicine because of their ability for self-renewal and differentiation into tissue-specific cells such as osteoblasts, chondrocytes, and adipocytes. MSCs orchestrate tissue development, maintenance and repair, and are useful for musculoskeletal regenerative therapies to treat age-related orthopedic degenerative diseases and other clinical conditions. Importantly, MSCs produce secretory factors that play critical roles in tissue repair that support both engraftment and trophic functions (autocrine and paracrine). The development of uniform protocols for both preparation and characterization of MSCs, including standardized functional assays for evaluation of their biological potential, are critical factors contributing to their clinical utility. Quality control and release criteria for MSCs should include cell surface markers, differentiation potential, and other essential cell parameters. For example, cell surface marker profiles (surfactome), bone-forming capacities in ectopic and orthotopic models, as well as cell size and granularity, telomere length, senescence status, trophic factor secretion (secretome), and immunomodulation, should be thoroughly assessed to predict MSC utility for regenerative medicine. We propose that these and other functionalities of MSCs should be characterized prior to use in clinical applications as part of comprehensive and uniform guidelines and release criteria for their clinical-grade production to achieve predictably favorable treatment outcomes for stem cell therapy.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Tế bào gốc trung mô (MSC) có tiềm năng lớn trong y học tái tạo nhờ khả năng tự làm mới và phân hóa thành các tế bào đặc hiệu cho mô như tế bào tạo xương (osteoblast), tế bào sụn (chondrocyte) và tế bào mỡ (adipocyte). MSC điều phối sự phát triển, duy trì và sửa chữa mô, và hữu ích trong các liệu pháp tái tạo cơ xương để điều trị các bệnh thoái hóa khớp do tuổi tác và các tình trạng lâm sàng khác. Quan trọng hơn, MSC sản xuất các yếu tố tiết ra có vai trò quan trọng trong việc sửa chữa mô hỗ trợ cho cả chức năng ghép (engraftment) và chức năng nuôi dưỡng (trophic) (tự nội tiết và ngoại tiết). Việc phát triển các quy trình đồng nhất cho cả việc chuẩn bị và đặc trưng hóa MSC, bao gồm các thử nghiệm chức năng tiêu chuẩn để đánh giá tiềm năng sinh học của chúng, là những yếu tố quan trọng góp phần vào tính khả thi lâm sàng của chúng. Các tiêu chí kiểm soát chất lượng và phát hành cho MSC cần bao gồm các dấu hiệu bề mặt tế bào, tiềm năng phân hóa và các thông số tế bào thiết yếu khác. Ví dụ, hồ sơ dấu hiệu bề mặt tế bào (surfactome), khả năng hình thành xương trong các mô hình ghép và mô hình chuẩn, cũng như kích thước tế bào và độ phân giải, chiều dài telomere, tình trạng lão hóa, sự tiết ra yếu tố nuôi dưỡng (secretome), và điều chỉnh miễn dịch, cần được đánh giá kỹ lưỡng để dự đoán tính khả thi của MSC cho y học tái tạo. Chúng tôi đề xuất rằng những chức năng này và các chức năng khác của MSC nên được đặc trưng trước khi sử dụng trong các ứng dụng lâm sàng như một phần của các hướng dẫn và tiêu chí phát hành đồng bộ cho sản xuất có tiêu chuẩn lâm sàng nhằm đạt được kết quả điều trị dao động thuận lợi dự đoán cho liệu pháp tế bào gốc.\u003C\u002Fjats:p>",{"EN":1769,"VI":1770},"Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine","Tổng quan ngắn gọn: Đặc trưng đa diện của tế bào gốc trung mô người để sử dụng trong y học tái tạo",{"VOID":1772},"29076267",{"VOID":1774},"10.1002\u002Fsctm.17-0129","2024-10-03T05:20:14.424+00:00",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F6\u002F12\u002F2173\u002F6454762",[1780,1821,1842,1859,1882,1899],{"id":1781,"sortIndex":36,"researcher":26,"roles":1782,"affiliations":1783,"properties":1814},"a22fa950-e042-4416-b6e9-f459229daae7",[],[1784,1794,1804],{"id":1785,"sortIndex":115,"affiliation":1786,"properties":26},"16fd9164-9bd6-4823-84b2-dfacd170c06c",{"id":1787,"createTime":1788,"updateTime":1788,"relativeEntities":1789,"slug":1790,"properties":1791,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"10fce6ef-5b33-45d4-8589-434041045f66","2024-10-03T05:20:14.449+00:00",[],"bDepartment-of-Biomedical-Engineering-National-University-of-Singapore-Singapore",{"title":1792},{"EN":1793},"bDepartment of Biomedical Engineering, National University of Singapore, Singapore",{"id":1795,"sortIndex":36,"affiliation":1796,"properties":26},"e3e98d2d-140b-4d0e-a379-ca9d5c4accb2",{"id":1797,"createTime":1798,"updateTime":1798,"relativeEntities":1799,"slug":1800,"properties":1801,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e4eb67c1-28df-4796-9966-a3bb6fc62ace","2024-10-03T05:20:14.443+00:00",[],"aGlycotherapeutics-Group-Institute-of-Medical-Biology-Agency-for-Science-Technology-and-Research-A-STAR-Singapore",{"title":1802},{"EN":1803},"aGlycotherapeutics Group, Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore",{"id":1805,"sortIndex":114,"affiliation":1806,"properties":26},"4a78462f-cf6a-4c3b-a789-67ee8d1e2687",{"id":1807,"createTime":1808,"updateTime":1808,"relativeEntities":1809,"slug":1810,"properties":1811,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2fc8b5dc-1f7d-4b24-b43e-d43b32dc8b99","2024-10-03T05:20:14.453+00:00",[],"cDepartment-of-Orthopaedic-Surgery-Mayo-Clinic-Rochester-Minnesota-USA",{"title":1812},{"EN":1813},"cDepartment of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota, USA",{"openalex":1815,"orcid":1817,"title":1819},{"VOID":1816},"A5089242774",{"VOID":1818},"https:\u002F\u002Forcid.org\u002F0000-0001-8804-8284",{"EN":1820},"Rebekah M. Samsonraj",{"id":1822,"sortIndex":59,"researcher":26,"roles":1823,"affiliations":1824,"properties":1835},"d6d2099d-b53f-43d4-849f-0b11c35b7e53",[],[1825],{"id":1826,"sortIndex":36,"affiliation":1827,"properties":26},"24efba14-1c8d-4d73-a7ed-061950f6f9ea",{"id":1828,"createTime":1829,"updateTime":1829,"relativeEntities":1830,"slug":1831,"properties":1832,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"aa5f5b26-a08b-468d-83a8-d7d23727cbaa","2024-10-03T05:20:14.488+00:00",[],"eDepartment-of-Orthopaedic-Surgery-Yong-Loo-Lin-School-of-Medicine-National-University-of-Singapore-Singapore",{"title":1833},{"EN":1834},"eDepartment of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore",{"openalex":1836,"orcid":1838,"title":1840},{"VOID":1837},"A5054426924",{"VOID":1839},"https:\u002F\u002Forcid.org\u002F0000-0002-1130-4558",{"EN":1841},"James Hoi Po Hui",{"id":1843,"sortIndex":114,"researcher":26,"roles":1844,"affiliations":1845,"properties":1852},"e729faad-0189-44b1-913b-3ae2d26ed673",[],[1846],{"id":1847,"sortIndex":36,"affiliation":1848,"properties":26},"23aa77f3-59f4-4ac9-9a1e-dca2b16926ff",{"id":1797,"createTime":1798,"updateTime":1798,"relativeEntities":1849,"slug":1800,"properties":1850,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1851},{"EN":1803},{"openalex":1853,"orcid":1855,"title":1857},{"VOID":1854},"A5056730499",{"VOID":1856},"https:\u002F\u002Forcid.org\u002F0000-0003-1270-7452",{"EN":1858},"Victor Nurcombe",{"id":1860,"sortIndex":162,"researcher":26,"roles":1861,"affiliations":1862,"properties":1875},"77075cf9-b3f5-4477-bebc-adaaca5cc110",[],[1863,1869],{"id":1864,"sortIndex":36,"affiliation":1865,"properties":26},"dff0754d-d5b7-4eef-b09c-41f57d1eb1ca",{"id":1797,"createTime":1798,"updateTime":1798,"relativeEntities":1866,"slug":1800,"properties":1867,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1868},{"EN":1803},{"id":1870,"sortIndex":115,"affiliation":1871,"properties":26},"03decf60-f619-40f2-9846-89360d1762e9",{"id":1828,"createTime":1829,"updateTime":1829,"relativeEntities":1872,"slug":1831,"properties":1873,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1874},{"EN":1834},{"openalex":1876,"orcid":1878,"title":1880},{"VOID":1877},"A5038986017",{"VOID":1879},"https:\u002F\u002Forcid.org\u002F0000-0001-8543-3056",{"EN":1881},"Simon M. Cool",{"id":1883,"sortIndex":111,"researcher":26,"roles":1884,"affiliations":1885,"properties":1892},"36c24f82-cbcb-4289-a6ad-7acbbd3b0917",[],[1886],{"id":1887,"sortIndex":36,"affiliation":1888,"properties":26},"a673abfb-03a4-481f-9846-0c723257007c",{"id":1807,"createTime":1808,"updateTime":1808,"relativeEntities":1889,"slug":1810,"properties":1890,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1891},{"EN":1813},{"openalex":1893,"orcid":1895,"title":1897},{"VOID":1894},"A5008755139",{"VOID":1896},"https:\u002F\u002Forcid.org\u002F0000-0002-4458-0946",{"EN":1898},"André J. van Wijnen",{"id":1900,"sortIndex":115,"researcher":26,"roles":1901,"affiliations":1902,"properties":1919},"7aa8d986-79ae-4ba1-b938-32842f9169d5",[],[1903,1913],{"id":1904,"sortIndex":115,"affiliation":1905,"properties":26},"cb3e1075-499b-462c-82b7-67d114d5a64a",{"id":1906,"createTime":1907,"updateTime":1907,"relativeEntities":1908,"slug":1909,"properties":1910,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"29a34973-c7ec-4bef-aed8-cb3b574d70c4","2024-10-03T05:20:14.466+00:00",[],"dCenter-for-Cell-Biology-and-Tissue-Engineering-Competence-Center-for-Tissue-Engineering-and-Substance-Testing-TEDD-Institute-for-Chemistry-and-Biotechnology-ZHAW-School-of-Life-Sciences-and-Facility-Management-Zurich-University-of-Applied-Sciences-Switzerland",{"title":1911},{"EN":1912},"dCenter for Cell Biology and Tissue Engineering, Competence Center for Tissue Engineering and Substance Testing (TEDD), Institute for Chemistry and Biotechnology, ZHAW School of Life Sciences and Facility Management, Zurich University of Applied Sciences, Switzerland",{"id":1914,"sortIndex":36,"affiliation":1915,"properties":26},"5cdbca8e-b726-4aed-8c37-8817e2ce6511",{"id":1787,"createTime":1788,"updateTime":1788,"relativeEntities":1916,"slug":1790,"properties":1917,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1918},{"EN":1793},{"openalex":1920,"orcid":1922,"title":1924},{"VOID":1921},"A5075382707",{"VOID":1923},"https:\u002F\u002Forcid.org\u002F0000-0002-2138-6614",{"EN":1925},"Michael Raghunath",{"url":26,"publisher":1927,"properties":1952},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1928,"slug":663,"properties":1929,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1935,"manageAffiliations":1936,"indexDatabases":1937,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":1930,"issn":1931,"introduce":1932,"eissn":1933,"title":1934},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[1938,1945],{"id":742,"indexDatabase":1939,"url":755,"indexYears":756,"academicFieldIds":1944,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":1940,"label":1941,"description":1942,"key":752,"publicationTags":1943,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":1946,"url":738,"indexYears":26,"academicFieldIds":1951,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":1947,"label":1948,"description":1949,"key":734,"publicationTags":1950,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":1953,"pages":1955,"issue":1957},{"VOID":1954},"6",{"VOID":1956},"2173-2185",{"VOID":1958},"12",582,{"total":1959,"publishYear":26,"statisticByYear":1961},{"2018":252,"2019":253,"2020":1962,"2021":533,"2022":1963,"2023":1964,"2024":569},99,100,104,"2017-12-01",2017,[1968,1972,1976,1980,1984,1988,1990,1994,1997,2001,2005,2009,2013,2017,2021,2025,2029,2033,2037,2041,2045,2049,2053,2057,2061,2065,2067,2070,2074,2077,2081,2085,2089,2093,2097,2101,2105,2109,2111,2115,2119,2123,2127,2131,2135,2139,2143,2147,2151,2155,2159,2163,2167,2171,2175,2179,2181,2184,2188,2192,2195,2199,2203,2207,2211,2215,2219,2223,2227,2231,2235,2239,2243,2247,2251,2255,2259,2263,2267,2271,2275,2279,2283,2287,2291,2295,2299,2303,2307,2311,2315,2319,2323,2327,2331,2334,2338,2342,2346,2350,2354,2358,2362,2366,2370,2374,2378,2382,2386,2389,2393,2397,2401,2405,2409,2413,2417,2421,2425,2429,2433,2437,2441,2445,2447,2450,2454,2458,2462,2466,2470,2474,2478,2482,2485,2487,2491,2495,2499,2503,2507,2511,2513,2517,2521,2525,2529,2533,2537,2541,2545,2549,2553,2557,2561,2565,2567,2571,2575,2579,2583,2587,2591,2594,2598,2602,2606,2610,2614,2618,2622,2626,2630,2634,2638,2642,2646,2650,2654,2658,2662,2666,2670,2674,2678,2682,2686,2690,2694,2697,2701,2704,2708,2711,2715,2719],{"id":26,"text":1969,"url":26,"identifiers":1970},"Caplan, 1991, Mesenchymal stem cells, J Orthop Res, 9, 641, 10.1002\u002Fjor.1100090504",{"doi":1971},"10.1002\u002Fjor.1100090504",{"id":26,"text":1973,"url":26,"identifiers":1974},"Corselli, 2013, Perivascular support of human hematopoietic stem\u002Fprogenitor cells, Blood, 121, 2891, 10.1182\u002Fblood-2012-08-451864",{"doi":1975},"10.1182\u002Fblood-2012-08-451864",{"id":26,"text":1977,"url":26,"identifiers":1978},"Crisan, 2008, A perivascular origin for mesenchymal stem cells in multiple human organs, Cell Stem Cell, 3, 301, 10.1016\u002Fj.stem.2008.07.003",{"doi":1979},"10.1016\u002Fj.stem.2008.07.003",{"id":26,"text":1981,"url":26,"identifiers":1982},"Blocki, 2013, Not all MSCs can act as pericytes: Functional in vitro assays to distinguish pericytes from other mesenchymal stem cells in angiogenesis, Stem Cells Dev, 22, 2347, 10.1089\u002Fscd.2012.0415",{"doi":1983},"10.1089\u002Fscd.2012.0415",{"id":26,"text":1985,"url":26,"identifiers":1986},"Sacchetti, 2007, Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment, Cell, 131, 324, 10.1016\u002Fj.cell.2007.08.025",{"doi":1987},"10.1016\u002Fj.cell.2007.08.025",{"id":26,"text":1721,"url":26,"identifiers":1989},{"doi":1723},{"id":26,"text":1991,"url":26,"identifiers":1992},"Samsonraj, 2015, Establishing criteria for human mesenchymal stem cell potency, Stem Cells, 33, 1878, 10.1002\u002Fstem.1982",{"doi":1993},"10.1002\u002Fstem.1982",{"id":26,"text":1995,"url":26,"identifiers":1996},"Friedenstein, 1970, The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells, Cell Tissue Kinet, 3, 393",{},{"id":26,"text":1998,"url":26,"identifiers":1999},"Castro-Malaspina, 1980, Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny, Blood, 56, 289, 10.1182\u002Fblood.V56.2.289.289",{"doi":2000},"10.1182\u002Fblood.V56.2.289.289",{"id":26,"text":2002,"url":26,"identifiers":2003},"Song, 2004, Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow, FASEB J, 18, 980, 10.1096\u002Ffj.03-1100fje",{"doi":2004},"10.1096\u002Ffj.03-1100fje",{"id":26,"text":2006,"url":26,"identifiers":2007},"Crain, 2005, Transplanted human bone marrow cells generate new brain cells, J Neurol Sci, 233, 121, 10.1016\u002Fj.jns.2005.03.017",{"doi":2008},"10.1016\u002Fj.jns.2005.03.017",{"id":26,"text":2010,"url":26,"identifiers":2011},"Krabbe, 2005, Neural transdifferentiation of mesenchymal stem cells–a critical review, APMIS, 113, 831, 10.1111\u002Fj.1600-0463.2005.apm_3061.x",{"doi":2012},"10.1111\u002Fj.1600-0463.2005.apm_3061.x",{"id":26,"text":2014,"url":26,"identifiers":2015},"Ries, 2012, Stem Cells and Cancer Stem Cells, Volume 8: Therapeutic Applications in Disease and Injury, 71, 10.1007\u002F978-94-007-4798-2_7",{"doi":2016},"10.1007\u002F978-94-007-4798-2_7",{"id":26,"text":2018,"url":26,"identifiers":2019},"Kopen, 1999, Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains, Proc Natl Acad Sci USA, 96, 10711, 10.1073\u002Fpnas.96.19.10711",{"doi":2020},"10.1073\u002Fpnas.96.19.10711",{"id":26,"text":2022,"url":26,"identifiers":2023},"Aguilar, 2016, Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus, Biochim Biophys Acta, 1859, 1043, 10.1016\u002Fj.bbagrm.2016.05.009",{"doi":2024},"10.1016\u002Fj.bbagrm.2016.05.009",{"id":26,"text":2026,"url":26,"identifiers":2027},"Okolicsanyi, 2015, Human mesenchymal stem cells retain multilineage differentiation capacity including neural marker expression after extended in vitro expansion, PLoS One, 10, e0137255, 10.1371\u002Fjournal.pone.0137255",{"doi":2028},"10.1371\u002Fjournal.pone.0137255",{"id":26,"text":2030,"url":26,"identifiers":2031},"Aust, 2004, Yield of human adipose-derived adult stem cells from liposuction aspirates, Cytotherapy, 6, 7, 10.1080\u002F14653240310004539",{"doi":2032},"10.1080\u002F14653240310004539",{"id":26,"text":2034,"url":26,"identifiers":2035},"Smiler, 2008, Toward the identification of mesenchymal stem cells in bone marrow and peripheral blood for bone regeneration, Implant Dent, 17, 236, 10.1097\u002FID.0b013e3181835b13",{"doi":2036},"10.1097\u002FID.0b013e3181835b13",{"id":26,"text":2038,"url":26,"identifiers":2039},"He, 2007, Concise review: Multipotent mesenchymal stromal cells in blood, Stem Cells, 25, 69, 10.1634\u002Fstemcells.2006-0335",{"doi":2040},"10.1634\u002Fstemcells.2006-0335",{"id":26,"text":2042,"url":26,"identifiers":2043},"Griffiths, 2005, Stem cells of the alveolar epithelium, Lancet, 366, 249, 10.1016\u002FS0140-6736(05)66916-4",{"doi":2044},"10.1016\u002FS0140-6736(05)66916-4",{"id":26,"text":2046,"url":26,"identifiers":2047},"Tuli, 2003, Current state of cartilage tissue engineering, Arthritis Res Ther, 5, 235, 10.1186\u002Far991",{"doi":2048},"10.1186\u002Far991",{"id":26,"text":2050,"url":26,"identifiers":2051},"Fan, 2009, Synovium-derived mesenchymal stem cells: A new cell source for musculoskeletal regeneration, Tissue Eng Part B Rev, 15, 75, 10.1089\u002Ften.teb.2008.0586",{"doi":2052},"10.1089\u002Ften.teb.2008.0586",{"id":26,"text":2054,"url":26,"identifiers":2055},"Gay, 2007, Isolation and characterization of multipotent human periodontal ligament stem cells, Orthod Craniofac Res, 10, 149, 10.1111\u002Fj.1601-6343.2007.00399.x",{"doi":2056},"10.1111\u002Fj.1601-6343.2007.00399.x",{"id":26,"text":2058,"url":26,"identifiers":2059},"Jackson, 2010, Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells, Expert Opin Biol Ther, 10, 505, 10.1517\u002F14712591003610606",{"doi":2060},"10.1517\u002F14712591003610606",{"id":26,"text":2062,"url":26,"identifiers":2063},"In't Anker, 2004, Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta, Stem Cells, 22, 1338, 10.1634\u002Fstemcells.2004-0058",{"doi":2064},"10.1634\u002Fstemcells.2004-0058",{"id":26,"text":974,"url":26,"identifiers":2066},{"doi":976},{"id":26,"text":2068,"url":26,"identifiers":2069},"Corrao, 2013, Umbilical cord revisited: From Wharton's jelly myofibroblasts to mesenchymal stem cells, Histol Histopathol, 28, 1235",{},{"id":26,"text":2071,"url":26,"identifiers":2072},"Erices, 2000, Mesenchymal progenitor cells in human umbilical cord blood, Br J Haematol, 109, 235, 10.1046\u002Fj.1365-2141.2000.01986.x",{"doi":2073},"10.1046\u002Fj.1365-2141.2000.01986.x",{"id":26,"text":2075,"url":26,"identifiers":2076},"Mareschi, 2001, Isolation of human mesenchymal stem cells: Bone marrow versus umbilical cord blood, Haematologica, 86, 1099",{},{"id":26,"text":2078,"url":26,"identifiers":2079},"Seo, 2004, Investigation of multipotent postnatal stem cells from human periodontal ligament, Lancet, 364, 149, 10.1016\u002FS0140-6736(04)16627-0",{"doi":2080},"10.1016\u002FS0140-6736(04)16627-0",{"id":26,"text":2082,"url":26,"identifiers":2083},"Shi, 2003, Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp, J Bone Miner Res, 18, 696, 10.1359\u002Fjbmr.2003.18.4.696",{"doi":2084},"10.1359\u002Fjbmr.2003.18.4.696",{"id":26,"text":2086,"url":26,"identifiers":2087},"Corselli, 2010, Perivascular ancestors of adult multipotent stem cells, Arterioscler Thromb Vasc Biol, 30, 1104, 10.1161\u002FATVBAHA.109.191643",{"doi":2088},"10.1161\u002FATVBAHA.109.191643",{"id":26,"text":2090,"url":26,"identifiers":2091},"Elahi, 2016, Human mesenchymal stromal cells from different sources diverge in their expression of cell surface proteins and display distinct differentiation patterns, Stem Cells Int, 2016, 5646384, 10.1155\u002F2016\u002F5646384",{"doi":2092},"10.1155\u002F2016\u002F5646384",{"id":26,"text":2094,"url":26,"identifiers":2095},"Kwon, 2016, Tissue-specific differentiation potency of mesenchymal stromal cells from perinatal tissues, Sci Rep, 6, 23544, 10.1038\u002Fsrep23544",{"doi":2096},"10.1038\u002Fsrep23544",{"id":26,"text":2098,"url":26,"identifiers":2099},"Davies, 2017, Concise review: Wharton's Jelly: The rich, but enigmatic, source of mesenchymal stromal cells, Stem Cells Translational Medicine, 6, 1620, 10.1002\u002Fsctm.16-0492",{"doi":2100},"10.1002\u002Fsctm.16-0492",{"id":26,"text":2102,"url":26,"identifiers":2103},"Chen, 2015, Comparative analysis of biological characteristics of adult mesenchymal stem cells with different tissue origins, Asian Pac J Trop Med, 8, 739, 10.1016\u002Fj.apjtm.2015.07.022",{"doi":2104},"10.1016\u002Fj.apjtm.2015.07.022",{"id":26,"text":2106,"url":26,"identifiers":2107},"Billing, 2016, Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers, Sci Rep, 6, 21507, 10.1038\u002Fsrep21507",{"doi":2108},"10.1038\u002Fsrep21507",{"id":26,"text":954,"url":26,"identifiers":2110},{"doi":956},{"id":26,"text":2112,"url":26,"identifiers":2113},"Rider, 2007, Selection using the alpha-1 integrin (CD49a) enhances the multipotentiality of the mesenchymal stem cell population from heterogeneous bone marrow stromal cells, J Mol Histol, 38, 449, 10.1007\u002Fs10735-007-9128-z",{"doi":2114},"10.1007\u002Fs10735-007-9128-z",{"id":26,"text":2116,"url":26,"identifiers":2117},"Hass, 2011, Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC, Cell Commun Signal CCS, 9, 12, 10.1186\u002F1478-811X-9-12",{"doi":2118},"10.1186\u002F1478-811X-9-12",{"id":26,"text":2120,"url":26,"identifiers":2121},"Maleki, 2014, Comparison of mesenchymal stem cell markers in multiple human adult stem cells, Int J Stem Cells, 7, 118, 10.15283\u002Fijsc.2014.7.2.118",{"doi":2122},"10.15283\u002Fijsc.2014.7.2.118",{"id":26,"text":2124,"url":26,"identifiers":2125},"Trounson, 2015, Stem cell therapies in clinical trials: Progress and challenges, Cell Stem Cell, 17, 11, 10.1016\u002Fj.stem.2015.06.007",{"doi":2126},"10.1016\u002Fj.stem.2015.06.007",{"id":26,"text":2128,"url":26,"identifiers":2129},"Monsarrat, 2016, An innovative, comprehensive mapping and multiscale analysis of registered trials for stem cell-based regenerative medicine, Stem Cells Translational Medicine, 5, 826, 10.5966\u002Fsctm.2015-0329",{"doi":2130},"10.5966\u002Fsctm.2015-0329",{"id":26,"text":2132,"url":26,"identifiers":2133},"Atoui, 2012, Concise review: Immunomodulatory properties of mesenchymal stem cells in cellular transplantation: Update, controversies, and unknowns, Stem Cells Translational Medicine, 1, 200, 10.5966\u002Fsctm.2011-0012",{"doi":2134},"10.5966\u002Fsctm.2011-0012",{"id":26,"text":2136,"url":26,"identifiers":2137},"Steinert, 2012, Concise review: The clinical application of mesenchymal stem cells for musculoskeletal regeneration: Current status and perspectives, Stem Cells Translational Medicine, 1, 237, 10.5966\u002Fsctm.2011-0036",{"doi":2138},"10.5966\u002Fsctm.2011-0036",{"id":26,"text":2140,"url":26,"identifiers":2141},"Hare, 2012, Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The POSEIDON randomized trial, JAMA, 308, 2369, 10.1001\u002Fjama.2012.25321",{"doi":2142},"10.1001\u002Fjama.2012.25321",{"id":26,"text":2144,"url":26,"identifiers":2145},"Kinkaid, 2010, What's new in cardiac cell therapy? Allogeneic bone marrow stromal cells as “universal donor cells, J Card Surg, 25, 359, 10.1111\u002Fj.1540-8191.2009.00984.x",{"doi":2146},"10.1111\u002Fj.1540-8191.2009.00984.x",{"id":26,"text":2148,"url":26,"identifiers":2149},"Zhang, 2015, The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy, Stem Cell Res Ther, 6, 234, 10.1186\u002Fs13287-015-0240-9",{"doi":2150},"10.1186\u002Fs13287-015-0240-9",{"id":26,"text":2152,"url":26,"identifiers":2153},"Griffin, 2013, Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?, Stem Cells, 31, 2033, 10.1002\u002Fstem.1452",{"doi":2154},"10.1002\u002Fstem.1452",{"id":26,"text":2156,"url":26,"identifiers":2157},"Alagesan, 2014, Autologous and allogeneic mesenchymal stem cells in organ transplantation: What do we know about their safety and efficacy?, Curr Opin Organ Transplant, 19, 65, 10.1097\u002FMOT.0000000000000043",{"doi":2158},"10.1097\u002FMOT.0000000000000043",{"id":26,"text":2160,"url":26,"identifiers":2161},"Grisendi, 2010, GMP-manufactured density gradient media for optimized mesenchymal stromal\u002Fstem cell isolation and expansion, Cytotherapy, 12, 466, 10.3109\u002F14653241003649510",{"doi":2162},"10.3109\u002F14653241003649510",{"id":26,"text":2164,"url":26,"identifiers":2165},"Gronthos, 2003, Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow, J Cell Sci, 116, 1827, 10.1242\u002Fjcs.00369",{"doi":2166},"10.1242\u002Fjcs.00369",{"id":26,"text":2168,"url":26,"identifiers":2169},"Miltenyi, 1990, High gradient magnetic cell separation with MACS, Cytometry, 11, 231, 10.1002\u002Fcyto.990110203",{"doi":2170},"10.1002\u002Fcyto.990110203",{"id":26,"text":2172,"url":26,"identifiers":2173},"Wagner, 2009, Optimizing mesenchymal stem cell-based therapeutics, Curr Opin Biotechnol, 20, 531, 10.1016\u002Fj.copbio.2009.08.009",{"doi":2174},"10.1016\u002Fj.copbio.2009.08.009",{"id":26,"text":2176,"url":26,"identifiers":2177},"Wagner, 2008, The stromal activity of mesenchymal stromal cells, Transfus Med Hemother, 35, 185, 10.1159\u002F000128956",{"doi":2178},"10.1159\u002F000128956",{"id":26,"text":966,"url":26,"identifiers":2180},{"doi":968},{"id":26,"text":2182,"url":26,"identifiers":2183},"Friedenstein, 1974, Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method, Exp Hematol, 2, 83",{},{"id":26,"text":2185,"url":26,"identifiers":2186},"Pochampally, 2008, Mesenchymal Stem Cells: Methods and Protocols, 83, 10.1007\u002F978-1-60327-169-1_6",{"doi":2187},"10.1007\u002F978-1-60327-169-1_6",{"id":26,"text":2189,"url":26,"identifiers":2190},"Caplan, 2009, Why are MSCs therapeutic? New data: New insight, J Pathol, 217, 318, 10.1002\u002Fpath.2469",{"doi":2191},"10.1002\u002Fpath.2469",{"id":26,"text":2193,"url":26,"identifiers":2194},"Haynesworth, 1994, 79",{},{"id":26,"text":2196,"url":26,"identifiers":2197},"Gronthos, 1994, The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors, Blood, 84, 4164, 10.1182\u002Fblood.V84.12.4164.bloodjournal84124164",{"doi":2198},"10.1182\u002Fblood.V84.12.4164.bloodjournal84124164",{"id":26,"text":2200,"url":26,"identifiers":2201},"Gronthos, 1995, The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro, Blood, 85, 929, 10.1182\u002Fblood.V85.4.929.bloodjournal854929",{"doi":2202},"10.1182\u002Fblood.V85.4.929.bloodjournal854929",{"id":26,"text":2204,"url":26,"identifiers":2205},"Gronthos, 1999, Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells, J Bone Miner Res, 14, 47, 10.1359\u002Fjbmr.1999.14.1.47",{"doi":2206},"10.1359\u002Fjbmr.1999.14.1.47",{"id":26,"text":2208,"url":26,"identifiers":2209},"Simmons, 1991, Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1, Blood, 78, 55, 10.1182\u002Fblood.V78.1.55.55",{"doi":2210},"10.1182\u002Fblood.V78.1.55.55",{"id":26,"text":2212,"url":26,"identifiers":2213},"Gang, 2007, SSEA-4 identifies mesenchymal stem cells from bone marrow, Blood, 109, 1743, 10.1182\u002Fblood-2005-11-010504",{"doi":2214},"10.1182\u002Fblood-2005-11-010504",{"id":26,"text":2216,"url":26,"identifiers":2217},"Jones, 2008, Human bone marrow mesenchymal stem cells in vivo, Rheumatology (Oxford), 47, 126, 10.1093\u002Frheumatology\u002Fkem206",{"doi":2218},"10.1093\u002Frheumatology\u002Fkem206",{"id":26,"text":2220,"url":26,"identifiers":2221},"Buhring, 2007, Novel markers for the prospective isolation of human MSC, Ann N Y Acad Sci, 1106, 262, 10.1196\u002Fannals.1392.000",{"doi":2222},"10.1196\u002Fannals.1392.000",{"id":26,"text":2224,"url":26,"identifiers":2225},"Quirici, 2002, Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies, Exp Hematol, 30, 783, 10.1016\u002FS0301-472X(02)00812-3",{"doi":2226},"10.1016\u002FS0301-472X(02)00812-3",{"id":26,"text":2228,"url":26,"identifiers":2229},"Buhring, 2009, Phenotypic characterization of distinct human bone marrow-derived MSC subsets, Ann N Y Acad Sci, 1176, 124, 10.1111\u002Fj.1749-6632.2009.04564.x",{"doi":2230},"10.1111\u002Fj.1749-6632.2009.04564.x",{"id":26,"text":2232,"url":26,"identifiers":2233},"Sobiesiak, 2010, The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase, Stem Cells Dev, 19, 669, 10.1089\u002Fscd.2009.0290",{"doi":2234},"10.1089\u002Fscd.2009.0290",{"id":26,"text":2236,"url":26,"identifiers":2237},"Halfon, 2011, Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging, Stem Cells Dev, 20, 53, 10.1089\u002Fscd.2010.0040",{"doi":2238},"10.1089\u002Fscd.2010.0040",{"id":26,"text":2240,"url":26,"identifiers":2241},"Jurisic, 2010, Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium, Exp Cell Res, 316, 2982, 10.1016\u002Fj.yexcr.2010.06.013",{"doi":2242},"10.1016\u002Fj.yexcr.2010.06.013",{"id":26,"text":2244,"url":26,"identifiers":2245},"Kisselbach, 2009, CD90 Expression on human primary cells and elimination of contaminating fibroblasts from cell cultures, Cytotechnology, 59, 31, 10.1007\u002Fs10616-009-9190-3",{"doi":2246},"10.1007\u002Fs10616-009-9190-3",{"id":26,"text":2248,"url":26,"identifiers":2249},"Ishii, 2005, Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts, Biochem Biophys Res Commun, 332, 297, 10.1016\u002Fj.bbrc.2005.04.118",{"doi":2250},"10.1016\u002Fj.bbrc.2005.04.118",{"id":26,"text":2252,"url":26,"identifiers":2253},"Fitter, 2017, The mesenchymal precursor cell marker antibody STRO-1 binds to cell surface heat shock cognate 70, Stem Cells, 35, 940, 10.1002\u002Fstem.2560",{"doi":2254},"10.1002\u002Fstem.2560",{"id":26,"text":2256,"url":26,"identifiers":2257},"Bianco, 2013, The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine, Nat Med, 19, 35, 10.1038\u002Fnm.3028",{"doi":2258},"10.1038\u002Fnm.3028",{"id":26,"text":2260,"url":26,"identifiers":2261},"Arthur, 2009, The therapeutic applications of multipotential mesenchymal\u002Fstromal stem cells in skeletal tissue repair, J Cell Physiol, 218, 237, 10.1002\u002Fjcp.21592",{"doi":2262},"10.1002\u002Fjcp.21592",{"id":26,"text":2264,"url":26,"identifiers":2265},"Bourin, 2013, Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal\u002Fstem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT), Cytotherapy, 15, 641, 10.1016\u002Fj.jcyt.2013.02.006",{"doi":2266},"10.1016\u002Fj.jcyt.2013.02.006",{"id":26,"text":2268,"url":26,"identifiers":2269},"Andersen, 2011, Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells, Mol Cells, 32, 133, 10.1007\u002Fs10059-011-2277-7",{"doi":2270},"10.1007\u002Fs10059-011-2277-7",{"id":26,"text":2272,"url":26,"identifiers":2273},"Tormin, 2011, CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization, Blood, 117, 5067, 10.1182\u002Fblood-2010-08-304287",{"doi":2274},"10.1182\u002Fblood-2010-08-304287",{"id":26,"text":2276,"url":26,"identifiers":2277},"Boxall, 2012, Markers for characterization of bone marrow multipotential stromal cells, Stem Cells Int, 2012, 12, 10.1155\u002F2012\u002F975871",{"doi":2278},"10.1155\u002F2012\u002F975871",{"id":26,"text":2280,"url":26,"identifiers":2281},"Deschaseaux, 2003, Direct selection of human bone marrow mesenchymal stem cells using an anti-CD49a antibody reveals their CD45(med, low) phenotype, Br J Haematol, 122, 506, 10.1046\u002Fj.1365-2141.2003.04469.x",{"doi":2282},"10.1046\u002Fj.1365-2141.2003.04469.x",{"id":26,"text":2284,"url":26,"identifiers":2285},"Tormin, 2009, CD146 expression in primary bone marrow MSC progenitor\u002Fstem cells is dependent on their in vivo location, Blood, 114, 107, 10.1182\u002Fblood.V114.22.251.251",{"doi":2286},"10.1182\u002Fblood.V114.22.251.251",{"id":26,"text":2288,"url":26,"identifiers":2289},"Jones, 2006, Optimization of a flow cytometry-based protocol for detection and phenotypic characterization of multipotent mesenchymal stromal cells from human bone marrow, Cytometry B Clin Cytom, 70B, 391, 10.1002\u002Fcyto.b.20118",{"doi":2290},"10.1002\u002Fcyto.b.20118",{"id":26,"text":2292,"url":26,"identifiers":2293},"Jones, 2002, Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells, Arthritis Rheum, 46, 3349, 10.1002\u002Fart.10696",{"doi":2294},"10.1002\u002Fart.10696",{"id":26,"text":2296,"url":26,"identifiers":2297},"Battula, 2009, Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1, Haematologica, 94, 173, 10.3324\u002Fhaematol.13740",{"doi":2298},"10.3324\u002Fhaematol.13740",{"id":26,"text":2300,"url":26,"identifiers":2301},"Nombela-Arrieta, 2011, The elusive nature and function of mesenchymal stem cells, Nat Rev Mol Cell Biol, 12, 126, 10.1038\u002Fnrm3049",{"doi":2302},"10.1038\u002Fnrm3049",{"id":26,"text":2304,"url":26,"identifiers":2305},"Mendez-Ferrer, 2010, Mesenchymal and haematopoietic stem cells form a unique bone marrow niche, Nature, 466, 829, 10.1038\u002Fnature09262",{"doi":2306},"10.1038\u002Fnature09262",{"id":26,"text":2308,"url":26,"identifiers":2309},"Morikawa, 2009, Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow, J Exp Med, 206, 2483, 10.1084\u002Fjem.20091046",{"doi":2310},"10.1084\u002Fjem.20091046",{"id":26,"text":2312,"url":26,"identifiers":2313},"Pinho, 2013, PDGFRα and CD51 mark human Nestin(+) sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion, J Exp Med, 210, 1351, 10.1084\u002Fjem.20122252",{"doi":2314},"10.1084\u002Fjem.20122252",{"id":26,"text":2316,"url":26,"identifiers":2317},"Zhou, 2014, Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow, Cell Stem Cell, 15, 154, 10.1016\u002Fj.stem.2014.06.008",{"doi":2318},"10.1016\u002Fj.stem.2014.06.008",{"id":26,"text":2320,"url":26,"identifiers":2321},"Jones, 2015, Where is the common ground between bone marrow mesenchymal stem\u002Fstromal cells from different donors and species?, Stem Cell Res Ther, 6, 143, 10.1186\u002Fs13287-015-0144-8",{"doi":2322},"10.1186\u002Fs13287-015-0144-8",{"id":26,"text":2324,"url":26,"identifiers":2325},"Camilleri, 2016, Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production, Stem Cell Res Ther, 7, 107, 10.1186\u002Fs13287-016-0370-8",{"doi":2326},"10.1186\u002Fs13287-016-0370-8",{"id":26,"text":2328,"url":26,"identifiers":2329},"Ong, 2014, Identification of specific cell-surface markers of adipose-derived stem cells from subcutaneous and visceral fat depots, Stem Cell Reports, 2, 171, 10.1016\u002Fj.stemcr.2014.01.002",{"doi":2330},"10.1016\u002Fj.stemcr.2014.01.002",{"id":26,"text":2332,"url":26,"identifiers":2333},"Reger, 2008, Differentiation and characterization of human MSCs, Methods Mol Biol, 449, 93",{},{"id":26,"text":2335,"url":26,"identifiers":2336},"Sarugaser, 2009, Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy, PLoS One, 4, e6498, 10.1371\u002Fjournal.pone.0006498",{"doi":2337},"10.1371\u002Fjournal.pone.0006498",{"id":26,"text":2339,"url":26,"identifiers":2340},"Bhakta, 2012, Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2, Biomaterials, 33, 6113, 10.1016\u002Fj.biomaterials.2012.05.030",{"doi":2341},"10.1016\u002Fj.biomaterials.2012.05.030",{"id":26,"text":2343,"url":26,"identifiers":2344},"Bramono, 2012, Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2), Bone, 50, 954, 10.1016\u002Fj.bone.2011.12.013",{"doi":2345},"10.1016\u002Fj.bone.2011.12.013",{"id":26,"text":2347,"url":26,"identifiers":2348},"Dombrowski, 2013, FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21(Waf1) and p27(Kip1), Stem Cells, 31, 2724, 10.1002\u002Fstem.1514",{"doi":2349},"10.1002\u002Fstem.1514",{"id":26,"text":2351,"url":26,"identifiers":2352},"Helledie, 2012, Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow, Stem Cells Dev, 21, 1897, 10.1089\u002Fscd.2011.0367",{"doi":2353},"10.1089\u002Fscd.2011.0367",{"id":26,"text":2355,"url":26,"identifiers":2356},"Ling, 2010, Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase\u002FAkt\u002FRUNX2 pathway, J Biol Chem, 285, 26233, 10.1074\u002Fjbc.M110.122069",{"doi":2357},"10.1074\u002Fjbc.M110.122069",{"id":26,"text":2359,"url":26,"identifiers":2360},"Teplyuk, 2009, The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor\u002Fproteoglycan signaling axis in osteoblasts, J Cell Biochem, 107, 144, 10.1002\u002Fjcb.22108",{"doi":2361},"10.1002\u002Fjcb.22108",{"id":26,"text":2363,"url":26,"identifiers":2364},"Scott, 2011, Current methods of adipogenic differentiation of mesenchymal stem cells, Stem Cells Dev, 20, 1793, 10.1089\u002Fscd.2011.0040",{"doi":2365},"10.1089\u002Fscd.2011.0040",{"id":26,"text":2367,"url":26,"identifiers":2368},"Johnstone, 1998, In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells, Exp Cell Res, 238, 265, 10.1006\u002Fexcr.1997.3858",{"doi":2369},"10.1006\u002Fexcr.1997.3858",{"id":26,"text":2371,"url":26,"identifiers":2372},"Mackay, 1998, Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow, Tissue Eng, 4, 415, 10.1089\u002Ften.1998.4.415",{"doi":2373},"10.1089\u002Ften.1998.4.415",{"id":26,"text":2375,"url":26,"identifiers":2376},"Barry, 2001, Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components, Exp Cell Res, 268, 189, 10.1006\u002Fexcr.2001.5278",{"doi":2377},"10.1006\u002Fexcr.2001.5278",{"id":26,"text":2379,"url":26,"identifiers":2380},"Hoch, 2014, Concise review: Optimizing expansion of bone marrow mesenchymal stem\u002Fstromal cells for clinical applications, Stem Cells Translational Medicine, 3, 643, 10.5966\u002Fsctm.2013-0196",{"doi":2381},"10.5966\u002Fsctm.2013-0196",{"id":26,"text":2383,"url":26,"identifiers":2384},"Riis, 2016, Comparative analysis of media and supplements on initiation and expansion of adipose-derived stem cells, Stem Cells Translational Medicine, 5, 314, 10.5966\u002Fsctm.2015-0148",{"doi":2385},"10.5966\u002Fsctm.2015-0148",{"id":26,"text":2387,"url":26,"identifiers":2388},"Pountos, 2014, Mesenchymal stem cell physiology can be affected by antibiotics: An in vitro study, Cell Mol Biol (Noisy-le-grand), 60, 1",{},{"id":26,"text":2390,"url":26,"identifiers":2391},"Petersen, 1999, Bone marrow as a potential source of hepatic oval cells, Science, 284, 1168, 10.1126\u002Fscience.284.5417.1168",{"doi":2392},"10.1126\u002Fscience.284.5417.1168",{"id":26,"text":2394,"url":26,"identifiers":2395},"Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126\u002Fscience.284.5411.143",{"doi":2396},"10.1126\u002Fscience.284.5411.143",{"id":26,"text":2398,"url":26,"identifiers":2399},"Quinn, 2008, In vivo differentiation potential of mesenchymal stem cells: Prenatal and postnatal model systems, Transfus Med Hemother, 35, 239, 10.1159\u002F000129129",{"doi":2400},"10.1159\u002F000129129",{"id":26,"text":2402,"url":26,"identifiers":2403},"Li, 2013, In vivo tracking and comparison of the therapeutic effects of MSCs and HSCs for liver injury, PLoS One, 8, e62363, 10.1371\u002Fjournal.pone.0062363",{"doi":2404},"10.1371\u002Fjournal.pone.0062363",{"id":26,"text":2406,"url":26,"identifiers":2407},"Munoz-Elias, 2004, Adult bone marrow stromal cells in the embryonic brain: Engraftment, migration, differentiation, and long-term survival, J Neurosci, 24, 4585, 10.1523\u002FJNEUROSCI.5060-03.2004",{"doi":2408},"10.1523\u002FJNEUROSCI.5060-03.2004",{"id":26,"text":2410,"url":26,"identifiers":2411},"Bae, 2007, Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration, Stem Cells, 25, 1307, 10.1634\u002Fstemcells.2006-0561",{"doi":2412},"10.1634\u002Fstemcells.2006-0561",{"id":26,"text":2414,"url":26,"identifiers":2415},"Liu, 2015, The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases, J Cell Mol Med, 19, 511, 10.1111\u002Fjcmm.12482",{"doi":2416},"10.1111\u002Fjcmm.12482",{"id":26,"text":2418,"url":26,"identifiers":2419},"Meier, 2013, Transplantation of mesenchymal stem cells for the treatment of liver diseases, is there enough evidence?, Stem Cell Res, 11, 1348, 10.1016\u002Fj.scr.2013.08.011",{"doi":2420},"10.1016\u002Fj.scr.2013.08.011",{"id":26,"text":2422,"url":26,"identifiers":2423},"Terada, 2002, Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion, Nature, 416, 542, 10.1038\u002Fnature730",{"doi":2424},"10.1038\u002Fnature730",{"id":26,"text":2426,"url":26,"identifiers":2427},"Sottile, 2016, Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis, Sci Rep, 6, 36863, 10.1038\u002Fsrep36863",{"doi":2428},"10.1038\u002Fsrep36863",{"id":26,"text":2430,"url":26,"identifiers":2431},"Nygren, 2004, Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation, Nat Med, 10, 494, 10.1038\u002Fnm1040",{"doi":2432},"10.1038\u002Fnm1040",{"id":26,"text":2434,"url":26,"identifiers":2435},"Muraglia, 2000, Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model, J Cell Sci, 113, 1161, 10.1242\u002Fjcs.113.7.1161",{"doi":2436},"10.1242\u002Fjcs.113.7.1161",{"id":26,"text":2438,"url":26,"identifiers":2439},"Pevsner-Fischer, 2011, The origins of mesenchymal stromal cell heterogeneity, Stem Cell Rev, 7, 560, 10.1007\u002Fs12015-011-9229-7",{"doi":2440},"10.1007\u002Fs12015-011-9229-7",{"id":26,"text":2442,"url":26,"identifiers":2443},"Russell, 2010, In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment, Stem Cells, 28, 788, 10.1002\u002Fstem.312",{"doi":2444},"10.1002\u002Fstem.312",{"id":26,"text":1638,"url":26,"identifiers":2446},{"doi":1640},{"id":26,"text":2448,"url":26,"identifiers":2449},"Lai, 2010, Exosome secreted by MSC reduces myocardial ischemia\u002Freperfusion injury, Stem Cell Res, 4, 214, 10.1016\u002Fj.scr.2009.12.003",{"doi":1593},{"id":26,"text":2451,"url":26,"identifiers":2452},"Amable, 2014, Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton's jelly, Stem Cell Res Ther, 5, 53-53, 10.1186\u002Fscrt442",{"doi":2453},"10.1186\u002Fscrt442",{"id":26,"text":2455,"url":26,"identifiers":2456},"Eirin, 2014, MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells, Gene, 551, 55, 10.1016\u002Fj.gene.2014.08.041",{"doi":2457},"10.1016\u002Fj.gene.2014.08.041",{"id":26,"text":2459,"url":26,"identifiers":2460},"Eirin, 2016, Comparative proteomic analysis of extracellular vesicles isolated from porcine adipose tissue-derived mesenchymal stem\u002Fstromal cells, Sci Rep, 6, 36120, 10.1038\u002Fsrep36120",{"doi":2461},"10.1038\u002Fsrep36120",{"id":26,"text":2463,"url":26,"identifiers":2464},"Hong, 2012, Perspectives on mesenchymal stem cells: Tissue repair, immune modulation, and tumor homing, Arch Pharm Res, 35, 201, 10.1007\u002Fs12272-012-0201-0",{"doi":2465},"10.1007\u002Fs12272-012-0201-0",{"id":26,"text":2467,"url":26,"identifiers":2468},"Marfy-Smith, 2017, Are mesenchymal stem cells so bloody great after all?, Stem Cells Translational Medicine, 6, 3, 10.5966\u002Fsctm.2016-0026",{"doi":2469},"10.5966\u002Fsctm.2016-0026",{"id":26,"text":2471,"url":26,"identifiers":2472},"Le Blanc, 2008, Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study, Lancet, 371, 1579, 10.1016\u002FS0140-6736(08)60690-X",{"doi":2473},"10.1016\u002FS0140-6736(08)60690-X",{"id":26,"text":2475,"url":26,"identifiers":2476},"Ortiz, 2007, Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury, Proc Natl Acad Sci USA, 104, 11002, 10.1073\u002Fpnas.0704421104",{"doi":2477},"10.1073\u002Fpnas.0704421104",{"id":26,"text":2479,"url":26,"identifiers":2480},"Shabbir, 2009, Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: A noninvasive therapeutic regimen, Am J Physiol Heart Circ Physiol, 296, H1888, 10.1152\u002Fajpheart.00186.2009",{"doi":2481},"10.1152\u002Fajpheart.00186.2009",{"id":26,"text":2483,"url":26,"identifiers":2484},"Dexter, 1989, Regulation of hemopoietic cell growth and development: Experimental and clinical studies, Leukemia, 3, 469",{},{"id":26,"text":1053,"url":26,"identifiers":2486},{"doi":1055},{"id":26,"text":2488,"url":26,"identifiers":2489},"Nicola, 2002, Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli, Blood, 99, 3838, 10.1182\u002Fblood.V99.10.3838",{"doi":2490},"10.1182\u002Fblood.V99.10.3838",{"id":26,"text":2492,"url":26,"identifiers":2493},"Centeno, 2008, Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells, Med Hypotheses, 71, 900, 10.1016\u002Fj.mehy.2008.06.042",{"doi":2494},"10.1016\u002Fj.mehy.2008.06.042",{"id":26,"text":2496,"url":26,"identifiers":2497},"Andrews, 2008, Human adult bone marrow-derived somatic cell therapy results in functional recovery and axonal plasticity following stroke in the rat, Exp Neurol, 211, 588, 10.1016\u002Fj.expneurol.2008.02.027",{"doi":2498},"10.1016\u002Fj.expneurol.2008.02.027",{"id":26,"text":2500,"url":26,"identifiers":2501},"Shabbir, 2010, Activation of host tissue trophic factors through JAK-STAT3 signaling: A mechanism of mesenchymal stem cell-mediated cardiac repair, Am J Physiol Heart Circ Physiol, 299, H1428, 10.1152\u002Fajpheart.00488.2010",{"doi":2502},"10.1152\u002Fajpheart.00488.2010",{"id":26,"text":2504,"url":26,"identifiers":2505},"Horwitz, 1999, Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta, Nat Med, 5, 309, 10.1038\u002F6529",{"doi":2506},"10.1038\u002F6529",{"id":26,"text":2508,"url":26,"identifiers":2509},"Luong-Van, 2007, The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells, J Mol Histol, 38, 459, 10.1007\u002Fs10735-007-9129-y",{"doi":2510},"10.1007\u002Fs10735-007-9129-y",{"id":26,"text":1061,"url":26,"identifiers":2512},{"doi":1063},{"id":26,"text":2514,"url":26,"identifiers":2515},"Lener, 2015, Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper, J Extracell Vesicles, 4, 30087, 10.3402\u002Fjev.v4.30087",{"doi":2516},"10.3402\u002Fjev.v4.30087",{"id":26,"text":2518,"url":26,"identifiers":2519},"Cruz, 2015, Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice, Stem Cells Translational Medicine, 4, 1302, 10.5966\u002Fsctm.2014-0280",{"doi":2520},"10.5966\u002Fsctm.2014-0280",{"id":26,"text":2522,"url":26,"identifiers":2523},"Reiner, 2017, Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles, Stem Cells Translational Medicine, 6, 1730, 10.1002\u002Fsctm.17-0055",{"doi":2524},"10.1002\u002Fsctm.17-0055",{"id":26,"text":2526,"url":26,"identifiers":2527},"Zhang, 2016, Focus on extracellular vesicles: Therapeutic potential of stem cell-derived extracellular vesicles, Int J Mol Sci, 17, 174, 10.3390\u002Fijms17020174",{"doi":2528},"10.3390\u002Fijms17020174",{"id":26,"text":2530,"url":26,"identifiers":2531},"Lo Sicco, 2017, Mesenchymal stem cell-derived extracellular vesicles as mediators of anti-inflammatory effects: Endorsement of macrophage polarization, Stem Cells Translational Medicine, 6, 1018, 10.1002\u002Fsctm.16-0363",{"doi":2532},"10.1002\u002Fsctm.16-0363",{"id":26,"text":2534,"url":26,"identifiers":2535},"Wen, 2016, Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells, Leukemia, 30, 2221, 10.1038\u002Fleu.2016.107",{"doi":2536},"10.1038\u002Fleu.2016.107",{"id":26,"text":2538,"url":26,"identifiers":2539},"Xie, 2017, Extracellular vesicle-functionalized decalcified bone matrix scaffolds with enhanced pro-angiogenic and pro-bone regeneration activities, Sci Rep, 7, 45622, 10.1038\u002Fsrep45622",{"doi":2540},"10.1038\u002Fsrep45622",{"id":26,"text":2542,"url":26,"identifiers":2543},"Pachler, 2017, A Good Manufacturing Practice-grade standard protocol for exclusively human mesenchymal stromal cell-derived extracellular vesicles, Cytotherapy, 19, 458, 10.1016\u002Fj.jcyt.2017.01.001",{"doi":2544},"10.1016\u002Fj.jcyt.2017.01.001",{"id":26,"text":2546,"url":26,"identifiers":2547},"Rai, 2010, Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells cultured on PCL-TCP scaffolds, Biomaterials, 31, 7960, 10.1016\u002Fj.biomaterials.2010.07.001",{"doi":2548},"10.1016\u002Fj.biomaterials.2010.07.001",{"id":26,"text":2550,"url":26,"identifiers":2551},"Glennie, 2005, Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells, Blood, 105, 2821, 10.1182\u002Fblood-2004-09-3696",{"doi":2552},"10.1182\u002Fblood-2004-09-3696",{"id":26,"text":2554,"url":26,"identifiers":2555},"Corcione, 2006, Human mesenchymal stem cells modulate B-cell functions, Blood, 107, 367, 10.1182\u002Fblood-2005-07-2657",{"doi":2556},"10.1182\u002Fblood-2005-07-2657",{"id":26,"text":2558,"url":26,"identifiers":2559},"Gonzalez, 2009, Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells, Arthritis Rheum, 60, 1006, 10.1002\u002Fart.24405",{"doi":2560},"10.1002\u002Fart.24405",{"id":26,"text":2562,"url":26,"identifiers":2563},"Ren, 2011, Adhesion molecules: Key players in mesenchymal stem cell-mediated immunosuppression, Cell Adh Migr, 5, 20, 10.4161\u002Fcam.5.1.13491",{"doi":2564},"10.4161\u002Fcam.5.1.13491",{"id":26,"text":1666,"url":26,"identifiers":2566},{"doi":1668},{"id":26,"text":2568,"url":26,"identifiers":2569},"Kyurkchiev, 2014, Secretion of immunoregulatory cytokines by mesenchymal stem cells, World J Stem Cells, 6, 552, 10.4252\u002Fwjsc.v6.i5.552",{"doi":2570},"10.4252\u002Fwjsc.v6.i5.552",{"id":26,"text":2572,"url":26,"identifiers":2573},"Selmani, 2008, Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells, Stem Cells, 26, 212, 10.1634\u002Fstemcells.2007-0554",{"doi":2574},"10.1634\u002Fstemcells.2007-0554",{"id":26,"text":2576,"url":26,"identifiers":2577},"Ren, 2008, Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide, Cell Stem Cell, 2, 141, 10.1016\u002Fj.stem.2007.11.014",{"doi":2578},"10.1016\u002Fj.stem.2007.11.014",{"id":26,"text":2580,"url":26,"identifiers":2581},"Lee, 2006, Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD\u002Fscid mice, Proc Natl Acad Sci USA, 103, 17438, 10.1073\u002Fpnas.0608249103",{"doi":2582},"10.1073\u002Fpnas.0608249103",{"id":26,"text":2584,"url":26,"identifiers":2585},"Corrao, 2013, New frontiers in regenerative medicine in cardiology: The potential of Wharton's jelly mesenchymal stem cells, Curr Stem Cell Res Ther, 8, 39, 10.2174\u002F1574888X11308010006",{"doi":2586},"10.2174\u002F1574888X11308010006",{"id":26,"text":2588,"url":26,"identifiers":2589},"Anzalone, 2010, New emerging potentials for human Wharton's jelly mesenchymal stem cells: Immunological features and hepatocyte-like differentiative capacity, Stem Cells Dev, 19, 423, 10.1089\u002Fscd.2009.0299",{"doi":2590},"10.1089\u002Fscd.2009.0299",{"id":26,"text":2592,"url":26,"identifiers":2593},"Squillaro, 2016, Clinical trials with mesenchymal stem cells: An Update. Cell, Transplant, 25, 829",{},{"id":26,"text":2595,"url":26,"identifiers":2596},"Miteva, 2016, Human endomyocardial biopsy specimen-derived stromal cells modulate angiotensin ii-induced cardiac remodeling, Stem Cells Translational Medicine, 5, 1707, 10.5966\u002Fsctm.2016-0031",{"doi":2597},"10.5966\u002Fsctm.2016-0031",{"id":26,"text":2599,"url":26,"identifiers":2600},"Kalluri, 2016, The biology and function of fibroblasts in cancer, Nat Rev Cancer, 16, 582, 10.1038\u002Fnrc.2016.73",{"doi":2601},"10.1038\u002Fnrc.2016.73",{"id":26,"text":2603,"url":26,"identifiers":2604},"Mattar, 2015, Comparing the immunomodulatory properties of bone marrow, adipose tissue, and birth-associated tissue mesenchymal stromal cells, Front Immunol, 6, 560, 10.3389\u002Ffimmu.2015.00560",{"doi":2605},"10.3389\u002Ffimmu.2015.00560",{"id":26,"text":2607,"url":26,"identifiers":2608},"Rhee, 2015, Mesenchymal stem cell-mediated effects of tumor support or suppression, Int J Mol Sci, 16, 30015, 10.3390\u002Fijms161226215",{"doi":2609},"10.3390\u002Fijms161226215",{"id":26,"text":2611,"url":26,"identifiers":2612},"Klopp, 2007, Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment, Cancer Res, 67, 11687, 10.1158\u002F0008-5472.CAN-07-1406",{"doi":2613},"10.1158\u002F0008-5472.CAN-07-1406",{"id":26,"text":2615,"url":26,"identifiers":2616},"Costanza, 2017, Stromal modulators of TGF-β in cancer, J Clin Med, 6, 7, 10.3390\u002Fjcm6010007",{"doi":2617},"10.3390\u002Fjcm6010007",{"id":26,"text":2619,"url":26,"identifiers":2620},"Lacerda, 2015, Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model, Breast Cancer Res, 17, 42, 10.1186\u002Fs13058-015-0549-4",{"doi":2621},"10.1186\u002Fs13058-015-0549-4",{"id":26,"text":2623,"url":26,"identifiers":2624},"Ridge, 2017, Mesenchymal stem cells: Key players in cancer progression, Mol Cancer, 16, 31, 10.1186\u002Fs12943-017-0597-8",{"doi":2625},"10.1186\u002Fs12943-017-0597-8",{"id":26,"text":2627,"url":26,"identifiers":2628},"Ye, 2012, Human bone marrow-derived mesenchymal stem cells produced TGFbeta contributes to progression and metastasis of prostate cancer, Cancer Invest, 30, 513, 10.3109\u002F07357907.2012.692171",{"doi":2629},"10.3109\u002F07357907.2012.692171",{"id":26,"text":2631,"url":26,"identifiers":2632},"Caimi, 2010, Emerging therapeutic approaches for multipotent mesenchymal stromal cells, Curr Opin Hematol, 17, 505, 10.1097\u002FMOH.0b013e32833e5b18",{"doi":2633},"10.1097\u002FMOH.0b013e32833e5b18",{"id":26,"text":2635,"url":26,"identifiers":2636},"Solchaga, 2010, Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells, Tissue Eng Part A, 16, 1009, 10.1089\u002Ften.tea.2009.0100",{"doi":2637},"10.1089\u002Ften.tea.2009.0100",{"id":26,"text":2639,"url":26,"identifiers":2640},"Parsch, 2004, Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes, J Mol Med (Berl), 82, 49, 10.1007\u002Fs00109-003-0506-z",{"doi":2641},"10.1007\u002Fs00109-003-0506-z",{"id":26,"text":2643,"url":26,"identifiers":2644},"Zimmermann, 2003, Lack of telomerase activity in human mesenchymal stem cells, Leukemia, 17, 1146, 10.1038\u002Fsj.leu.2402962",{"doi":2645},"10.1038\u002Fsj.leu.2402962",{"id":26,"text":2647,"url":26,"identifiers":2648},"Sethe, 2006, Aging of mesenchymal stem cells, Ageing Res Rev, 5, 91, 10.1016\u002Fj.arr.2005.10.001",{"doi":2649},"10.1016\u002Fj.arr.2005.10.001",{"id":26,"text":2651,"url":26,"identifiers":2652},"Samsonraj, 2013, Telomere length analysis of human mesenchymal stem cells by quantitative PCR, Gene, 519, 348, 10.1016\u002Fj.gene.2013.01.039",{"doi":2653},"10.1016\u002Fj.gene.2013.01.039",{"id":26,"text":2655,"url":26,"identifiers":2656},"Hemeda, 2014, Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells, Cytotherapy, 16, 170, 10.1016\u002Fj.jcyt.2013.11.004",{"doi":2657},"10.1016\u002Fj.jcyt.2013.11.004",{"id":26,"text":2659,"url":26,"identifiers":2660},"Spees, 2004, Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy, Mol Ther, 9, 747, 10.1016\u002Fj.ymthe.2004.02.012",{"doi":2661},"10.1016\u002Fj.ymthe.2004.02.012",{"id":26,"text":2663,"url":26,"identifiers":2664},"Bieback, 2013, Platelet lysate as replacement for fetal bovine serum in mesenchymal stromal cell cultures, Transfus Med Hemother, 40, 326, 10.1159\u002F000354061",{"doi":2665},"10.1159\u002F000354061",{"id":26,"text":2667,"url":26,"identifiers":2668},"Bieback, 2009, Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow, Stem Cells, 27, 2331, 10.1002\u002Fstem.139",{"doi":2669},"10.1002\u002Fstem.139",{"id":26,"text":2671,"url":26,"identifiers":2672},"Wijesinghe, 2017, Affinity selection of FGF2-binding heparan sulfates for ex vivo expansion of human mesenchymal stem cells, J Cell Physiol, 232, 566, 10.1002\u002Fjcp.25454",{"doi":2673},"10.1002\u002Fjcp.25454",{"id":26,"text":2675,"url":26,"identifiers":2676},"Ling, 2016, Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells, Gene, 576, 292, 10.1016\u002Fj.gene.2015.10.039",{"doi":2677},"10.1016\u002Fj.gene.2015.10.039",{"id":26,"text":2679,"url":26,"identifiers":2680},"Gibson, 2017, Regeneration of articular cartilage by human esc-derived mesenchymal progenitors treated sequentially with BMP-2 and Wnt5a, Stem Cells Translational Medicine, 6, 40, 10.5966\u002Fsctm.2016-0020",{"doi":2681},"10.5966\u002Fsctm.2016-0020",{"id":26,"text":2683,"url":26,"identifiers":2684},"Eaker, 2013, Concise review: Guidance in developing commercializable autologous\u002Fpatient-specific cell therapy manufacturing, Stem Cells Translational Medicine, 2, 871, 10.5966\u002Fsctm.2013-0050",{"doi":2685},"10.5966\u002Fsctm.2013-0050",{"id":26,"text":2687,"url":26,"identifiers":2688},"Muller-Cohn, 2015, Stem Cells in Regenerative Medicine, 341, 10.1002\u002F9781118846193.ch18",{"doi":2689},"10.1002\u002F9781118846193.ch18",{"id":26,"text":2691,"url":26,"identifiers":2692},"Schnitzler, 2016, Bioprocessing of human mesenchymal stem\u002Fstromal cells for therapeutic use: Current technologies and challenges, Biochem Eng J, 108, 3, 10.1016\u002Fj.bej.2015.08.014",{"doi":2693},"10.1016\u002Fj.bej.2015.08.014",{"id":26,"text":2695,"url":26,"identifiers":2696},"Research, 2017, 150",{},{"id":26,"text":2698,"url":26,"identifiers":2699},"Nery, 2013, Human mesenchymal stem cells: From immunophenotyping by flow cytometry to clinical applications, Cytometry Part A, 83A, 48, 10.1002\u002Fcyto.a.22205",{"doi":2700},"10.1002\u002Fcyto.a.22205",{"id":26,"text":2702,"url":26,"identifiers":2703},"Caplan, 2016, The 3Rs of cell therapy, Stem Cells Translational Medicine",{},{"id":26,"text":2705,"url":26,"identifiers":2706},"Gronthos, 2007, A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cells, Stem Cells Dev, 16, 953, 10.1089\u002Fscd.2007.0069",{"doi":2707},"10.1089\u002Fscd.2007.0069",{"id":26,"text":2709,"url":26,"identifiers":2710},"Bubnic, 2008",{},{"id":26,"text":2712,"url":26,"identifiers":2713},"Smith, 2004, Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma, Stem Cells, 22, 823, 10.1634\u002Fstemcells.22-5-823",{"doi":2714},"10.1634\u002Fstemcells.22-5-823",{"id":26,"text":2716,"url":26,"identifiers":2717},"Gupta, 2013, A double blind randomized placebo controlled phase I\u002FII study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia, J Transl Med, 11, 143, 10.1186\u002F1479-5876-11-143",{"doi":2718},"10.1186\u002F1479-5876-11-143",{"id":26,"text":2720,"url":26,"identifiers":2721},"Gupta, 2017, Administration of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells in critical limb ischemia due to Buerger's disease: Phase II study report suggests clinical efficacy, Stem Cells Translational Medicine, 6, 689, 10.5966\u002Fsctm.2016-0237",{"doi":2722},"10.5966\u002Fsctm.2016-0237",{"id":2724,"createTime":2725,"updateTime":2726,"relativeEntities":2727,"slug":2728,"properties":2729,"entityType":792,"verifyStatus":25,"verifyTime":2725,"verifyNote":793,"syncStatus":28,"languages":2747,"translateLanguages":2748,"viewCount":36,"primaryUrl":2749,"fullTextUrl":26,"authors":2750,"publicationType":877,"publisherRelationship":2872,"citationCount":2903,"citationInfo":2904,"publishDate":2907,"publishYear":1966,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2908,"isForceReanalyzing":1210},"e1ade20b-5717-4c50-ad6d-fe012694ae1c","2024-10-14T04:23:49.766+00:00","2025-02-22T15:12:53.974+00:00",[],"Cartilage-Regeneration-in-Osteoarthritic-Patients-by-a-Composite-of-Allogeneic-Umbilical-Cord-Blood-Derived-Mesenchymal-Stem-Cells-and-Hyaluronate-Hydrogel-Results-from-a-Clinical-Trial-for-Safety-and-Proof-of-Concept-with-7-Years-of-Extended-Follow-Up",{"mag":2730,"keywords":2732,"pmc":2733,"openalex":2735,"abstract":2737,"title":2740,"pm":2743,"doi":2745},{"VOID":2731},"2511760972",{"VI":777},{"VOID":2734},"5442809",{"VOID":2736},"W2511760972",{"EN":2738,"VI":2739},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Few methods are available to regenerate articular cartilage defects in patients with osteoarthritis. We aimed to assess the safety and efficacy of articular cartilage regeneration by a novel medicinal product composed of allogeneic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs). Patients with Kellgren-Lawrence grade 3 osteoarthritis and International Cartilage Repair Society (ICRS) grade 4 cartilage defects were enrolled in this clinical trial. The stem cell-based medicinal product (a composite of culture-expanded allogeneic hUCB-MSCs and hyaluronic acid hydrogel [Cartistem]) was applied to the lesion site. Safety was assessed by the World Health Organization common toxicity criteria. The primary efficacy outcome was ICRS cartilage repair assessed by arthroscopy at 12 weeks. The secondary efficacy outcome was visual analog scale (VAS) score for pain on walking. During a 7-year extended follow-up, we evaluated safety, VAS score, International Knee Documentation Committee (IKDC) subjective score, magnetic resonance imaging (MRI) findings, and histological evaluations. Seven participants were enrolled. Maturing repair tissue was observed at the 12-week arthroscopic evaluation. The VAS and IKDC scores were improved at 24 weeks. The improved clinical outcomes were stable over 7 years of follow-up. The histological findings at 1 year showed hyaline-like cartilage. MRI at 3 years showed persistence of the regenerated cartilage. Only five mild to moderate treatment-emergent adverse events were observed. There were no cases of osteogenesis or tumorigenesis over 7 years. The application of this novel stem cell-based medicinal product appears to be safe and effective for the regeneration of durable articular cartilage in osteoarthritic knees.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm Tắt\u003C\u002Fjats:title>\n               \u003Cjats:p>Chỉ có một vài phương pháp có sẵn để tái tạo các khuyết tật sụn khớp ở bệnh nhân bị thoái hóa khớp. Chúng tôi nhằm mục tiêu đánh giá độ an toàn và hiệu quả của việc tái tạo sụn khớp thông qua một sản phẩm dược phẩm mới được chế tạo từ tế bào gốc trung mô (hUCB-MSCs) lấy từ máu dây rốn người đồng loại. Các bệnh nhân bị thoái hóa khớp Kellgren-Lawrence độ 3 và có khuyết tật sụn độ 4 theo Tiêu Chí Sửa Chữa Sụn Quốc Tế (ICRS) đã được ghi danh vào thử nghiệm lâm sàng này. Sản phẩm dược phẩm dựa trên tế bào gốc (composite của hUCB-MSCs nhân nuôi và gel hyaluronic acid [Cartistem]) được áp dụng vào vị trí tổn thương. Độ an toàn được đánh giá bằng tiêu chí độc tính chung của Tổ Chức Y Tế Thế Giới. Kết quả chính đánh giá hiệu quả là sửa chữa sụn ICRS được đánh giá bằng nội soi sau 12 tuần. Kết quả thứ cấp là điểm số thang đánh giá đau (VAS) khi đi lại. Trong suốt 7 năm theo dõi mở rộng, chúng tôi đã đánh giá độ an toàn, điểm VAS, điểm chủ quan theo Ủy Ban Tài Liệu Gối Quốc Tế (IKDC), kết quả hình ảnh cộng hưởng từ (MRI), và đánh giá mô học. Bảy người tham gia đã được ghi danh. Mô sụn phục hồi đang phát triển được quan sát thấy trong đánh giá nội soi sau 12 tuần. Điểm VAS và IKDC đã cải thiện sau 24 tuần. Các kết quả lâm sàng được cải thiện ổn định trong suốt 7 năm theo dõi. Các phát hiện mô học sau 1 năm cho thấy có sụn tương tự như sụn hyaline. MRI sau 3 năm cho thấy sự tồn tại của sụn tái tạo. Chỉ có năm trường hợp biến chứng nhẹ đến vừa được ghi nhận. Không có trường hợp tạo xương hay khối u nào được phát hiện trong 7 năm theo dõi. Việc áp dụng sản phẩm dược phẩm mới dựa trên tế bào gốc này dường như là an toàn và hiệu quả cho việc tái tạo sụn khớp bền vững ở khớp gối bị thoái hóa.",{"EN":2741,"VI":2742},"Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up","Tái Tạo Sụn Khớp Ở Bệnh Nhân Bị Thoái Hóa Khớp Qua Hợp Chất Chứa Tế Bào Gốc Từ Máu Dây Rốn Và Gel Hyaluronate: Kết Quả Từ Một Nghiên Cứu Lâm Sàng Đánh Giá An Toàn Và Chứng Minh Khái Niệm Với Thời Gian Theo Dõi Kéo Dài 7 Năm",{"VOID":2744},"28191757",{"VOID":2746},"10.5966\u002Fsctm.2016-0157",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F6\u002F2\u002F613\u002F6404831",[2751,2792,2813,2834,2851],{"id":2752,"sortIndex":115,"researcher":26,"roles":2753,"affiliations":2754,"properties":2785},"df2cce47-e173-4a16-8299-0bcf30cd18f0",[],[2755,2765,2775],{"id":2756,"sortIndex":115,"affiliation":2757,"properties":26},"36a171f6-f7e5-41f4-a640-54f0dc192b2a",{"id":2758,"createTime":2759,"updateTime":2759,"relativeEntities":2760,"slug":2761,"properties":2762,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"1a0aba5f-da15-4f1b-b0de-9da8acd997a1","2024-10-14T04:23:49.798+00:00",[],"cStem-Cell-Regenerative-Medicine-Research-Institute-Samsung-Medical-Center-Sungkyunkwan-University-School-of-Medicine-Seoul-Republic-of-Korea",{"title":2763},{"EN":2764},"cStem Cell & Regenerative Medicine Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea",{"id":2766,"sortIndex":36,"affiliation":2767,"properties":26},"07627f92-2aa9-46b9-9c7e-15153a46c584",{"id":2768,"createTime":2769,"updateTime":2769,"relativeEntities":2770,"slug":2771,"properties":2772,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"5283a4fa-1815-4429-a119-22eebc0de9cf","2024-10-14T04:23:49.793+00:00",[],"bDepartment-of-Orthopedic-Surgery-Samsung-Medical-Center-Sungkyunkwan-University-School-of-Medicine-Seoul-Republic-of-Korea",{"title":2773},{"EN":2774},"bDepartment of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea",{"id":2776,"sortIndex":114,"affiliation":2777,"properties":26},"f427a438-8e00-43e0-a748-7782b914c3aa",{"id":2778,"createTime":2779,"updateTime":2779,"relativeEntities":2780,"slug":2781,"properties":2782,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"15c038a3-0c9c-4fee-b9c0-082f94c67c34","2024-10-14T04:23:49.803+00:00",[],"dDepartment-of-Health-Sciences-and-Technology-Samsung-Advanced-Institute-of-Health-Sciences-and-Technology-Sungkyunkwan-University-Seoul-Republic-of-Korea",{"title":2783},{"EN":2784},"dDepartment of Health Sciences and Technology, Samsung Advanced Institute of Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea",{"openalex":2786,"orcid":2788,"title":2790},{"VOID":2787},"A5002118713",{"VOID":2789},"https:\u002F\u002Forcid.org\u002F0000-0001-5123-6513",{"EN":2791},"Chul‐Won Ha",{"id":2793,"sortIndex":111,"researcher":26,"roles":2794,"affiliations":2795,"properties":2806},"6b5468ea-16ed-4a85-a5ed-7d3e9f8655b9",[],[2796],{"id":2797,"sortIndex":36,"affiliation":2798,"properties":26},"d43dfa7c-e33e-437b-bd59-57af8497aee6",{"id":2799,"createTime":2800,"updateTime":2800,"relativeEntities":2801,"slug":2802,"properties":2803,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"727ffbec-a8fa-4159-a6dc-b09c7dfd7cae","2024-10-14T04:23:49.838+00:00",[],"fDepartment-of-Orthopedic-Surgery-Jeju-National-University-Hospital-Jeju-National-University-School-of-Medicine-Jeju-Republic-of-Korea",{"title":2804},{"EN":2805},"fDepartment of Orthopedic Surgery, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea",{"openalex":2807,"orcid":2809,"title":2811},{"VOID":2808},"A5101902029",{"VOID":2810},"https:\u002F\u002Forcid.org\u002F0000-0002-9156-1203",{"EN":2812},"Yong‐Geun Park",{"id":2814,"sortIndex":59,"researcher":26,"roles":2815,"affiliations":2816,"properties":2827},"bc1cc49a-7a25-47fc-8dcb-52ff507f9bdb",[],[2817],{"id":2818,"sortIndex":36,"affiliation":2819,"properties":26},"1309c5b3-a815-4042-b372-88d37e566841",{"id":2820,"createTime":2821,"updateTime":2821,"relativeEntities":2822,"slug":2823,"properties":2824,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d0799d8d-044b-4dc1-aaf7-e87d5928b522","2024-10-14T04:23:49.824+00:00",[],"eDepartment-of-Radiology-Samsung-Medical-Center-Sungkyunkwan-University-School-of-Medicine-Seoul-Republic-of-Korea",{"title":2825},{"EN":2826},"eDepartment of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea",{"openalex":2828,"orcid":2830,"title":2832},{"VOID":2829},"A5022690482",{"VOID":2831},"https:\u002F\u002Forcid.org\u002F0000-0002-7822-5344",{"EN":2833},"Young Cheol Yoon",{"id":2835,"sortIndex":114,"researcher":26,"roles":2836,"affiliations":2837,"properties":2844},"cc8e632a-0768-4c9a-ae99-45f4f32ecb6b",[],[2838],{"id":2839,"sortIndex":36,"affiliation":2840,"properties":26},"483cf89a-d97e-4b30-a205-b8481795a0f9",{"id":2768,"createTime":2769,"updateTime":2769,"relativeEntities":2841,"slug":2771,"properties":2842,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2843},{"EN":2774},{"openalex":2845,"orcid":2847,"title":2849},{"VOID":2846},"A5003220970",{"VOID":2848},"https:\u002F\u002Forcid.org\u002F0000-0002-7808-8554",{"EN":2850},"Choong‐Hee Lee",{"id":2852,"sortIndex":36,"researcher":26,"roles":2853,"affiliations":2854,"properties":2865},"2675971d-6cb2-4de4-8668-e6156e199d71",[],[2855],{"id":2856,"sortIndex":36,"affiliation":2857,"properties":26},"40e816fe-fb35-4e52-9270-df215b822852",{"id":2858,"createTime":2859,"updateTime":2859,"relativeEntities":2860,"slug":2861,"properties":2862,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d1a1d28b-fc15-49bb-9345-58ece79e76aa","2024-10-14T04:23:49.781+00:00",[],"aDepartment-of-Orthopedic-Surgery-Chung-Ang-University-Hospital-Chung-Ang-University-College-of-Medicine-Seoul-Republic-of-Korea",{"title":2863},{"EN":2864},"aDepartment of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea",{"openalex":2866,"orcid":2868,"title":2870},{"VOID":2867},"A5101902027",{"VOID":2869},"https:\u002F\u002Forcid.org\u002F0000-0002-3741-2311",{"EN":2871},"Yong‐Beom Park",{"url":26,"publisher":2873,"properties":2898},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2874,"slug":663,"properties":2875,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2881,"manageAffiliations":2882,"indexDatabases":2883,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":2876,"issn":2877,"introduce":2878,"eissn":2879,"title":2880},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[2884,2891],{"id":742,"indexDatabase":2885,"url":755,"indexYears":756,"academicFieldIds":2890,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":2886,"label":2887,"description":2888,"key":752,"publicationTags":2889,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":2892,"url":738,"indexYears":26,"academicFieldIds":2897,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":2893,"label":2894,"description":2895,"key":734,"publicationTags":2896,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":2899,"pages":2900,"issue":2902},{"VOID":1954},{"VOID":2901},"613-621",{"VOID":910},355,{"total":2903,"publishYear":26,"statisticByYear":2905},{"2017":173,"2018":516,"2019":240,"2020":569,"2021":44,"2022":2906,"2023":204,"2024":398},82,"2017-02-01",[2909,2913,2917,2921,2925,2929,2933,2937,2941,2944,2948,2952,2956,2960,2964,2968,2972,2976,2980,2984,2988,2992,2996,3000,3004,3008,3010,3014,3018,3022,3026,3029],{"id":26,"text":2910,"url":26,"identifiers":2911},"Seo, 2011, Management of focal chondral lesion in the knee joint, Knee Surg Relat Res, 23, 185, 10.5792\u002Fksrr.2011.23.4.185",{"doi":2912},"10.5792\u002Fksrr.2011.23.4.185",{"id":26,"text":2914,"url":26,"identifiers":2915},"Goyal, 2013, Evidence-based status of microfracture technique: A systematic review of level I and II studies, Arthroscopy, 29, 1579, 10.1016\u002Fj.arthro.2013.05.027",{"doi":2916},"10.1016\u002Fj.arthro.2013.05.027",{"id":26,"text":2918,"url":26,"identifiers":2919},"Mithoefer, 2009, Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: An evidence-based systematic analysis, Am J Sports Med, 37, 2053, 10.1177\u002F0363546508328414",{"doi":2920},"10.1177\u002F0363546508328414",{"id":26,"text":2922,"url":26,"identifiers":2923},"Lee, 2013, Results of microfracture in the osteoarthritic knee with focal full-thickness articular cartilage defects and concomitant medial meniscal tears, Knee Surg Relat Res, 25, 71, 10.5792\u002Fksrr.2013.25.2.71",{"doi":2924},"10.5792\u002Fksrr.2013.25.2.71",{"id":26,"text":2926,"url":26,"identifiers":2927},"Martin, 2003, The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair, J Bone Joint Surg Am, 85-A, 106, 10.2106\u002F00004623-200300002-00014",{"doi":2928},"10.2106\u002F00004623-200300002-00014",{"id":26,"text":2930,"url":26,"identifiers":2931},"Tuan, 2003, Adult mesenchymal stem cells and cell-based tissue engineering, Arthritis Res Ther, 5, 32, 10.1186\u002Far614",{"doi":2932},"10.1186\u002Far614",{"id":26,"text":2934,"url":26,"identifiers":2935},"Koh, 2013, Mesenchymal stem cell injections improve symptoms of knee osteoarthritis, Arthroscopy, 29, 748, 10.1016\u002Fj.arthro.2012.11.017",{"doi":2936},"10.1016\u002Fj.arthro.2012.11.017",{"id":26,"text":2938,"url":26,"identifiers":2939},"Ha, 2014, Mesenchymal stem cells versus fat pad-derived cells, Arthroscopy, 30, 419, 10.1016\u002Fj.arthro.2014.01.015",{"doi":2940},"10.1016\u002Fj.arthro.2014.01.015",{"id":26,"text":2942,"url":26,"identifiers":2943},"Varma, 2010, The new avenues in the management of osteo-arthritis of knee––stem cells, J Indian Med Assoc, 108, 583",{},{"id":26,"text":2945,"url":26,"identifiers":2946},"Jo, 2014, Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: A proof-of-concept clinical trial, Stem Cells, 32, 1254, 10.1002\u002Fstem.1634",{"doi":2947},"10.1002\u002Fstem.1634",{"id":26,"text":2949,"url":26,"identifiers":2950},"Wakitani, 2002, Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees, Osteoarthritis Cartilage, 10, 199, 10.1053\u002Fjoca.2001.0504",{"doi":2951},"10.1053\u002Fjoca.2001.0504",{"id":26,"text":2953,"url":26,"identifiers":2954},"Wakitani, 2011, Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months, J Tissue Eng Regen Med, 5, 146, 10.1002\u002Fterm.299",{"doi":2955},"10.1002\u002Fterm.299",{"id":26,"text":2957,"url":26,"identifiers":2958},"Flynn, 2007, UC blood-derived mesenchymal stromal cells: An overview, Cytotherapy, 9, 717, 10.1080\u002F14653240701584578",{"doi":2959},"10.1080\u002F14653240701584578",{"id":26,"text":2961,"url":26,"identifiers":2962},"Kern, 2006, Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue, Stem Cells, 24, 1294, 10.1634\u002Fstemcells.2005-0342",{"doi":2963},"10.1634\u002Fstemcells.2005-0342",{"id":26,"text":2965,"url":26,"identifiers":2966},"Chung, 2014, Comparison of articular cartilage repair with different hydrogel-human umbilical cord blood-derived mesenchymal stem cell composites in a rat model, Stem Cell Res Ther, 5, 39, 10.1186\u002Fscrt427",{"doi":2967},"10.1186\u002Fscrt427",{"id":26,"text":2969,"url":26,"identifiers":2970},"Yang, 2004, Mesenchymal stem\u002Fprogenitor cells developed in cultures from UC blood, Cytotherapy, 6, 476, 10.1080\u002F14653240410005041",{"doi":2971},"10.1080\u002F14653240410005041",{"id":26,"text":2973,"url":26,"identifiers":2974},"Trotti, 2003, CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment, Semin Radiat Oncol, 13, 176, 10.1016\u002FS1053-4296(03)00031-6",{"doi":2975},"10.1016\u002FS1053-4296(03)00031-6",{"id":26,"text":2977,"url":26,"identifiers":2978},"Smith, 2005, Arthroscopic assessment of cartilage repair: A validation study of 2 scoring systems, Arthroscopy, 21, 1462, 10.1016\u002Fj.arthro.2005.09.007",{"doi":2979},"10.1016\u002Fj.arthro.2005.09.007",{"id":26,"text":2981,"url":26,"identifiers":2982},"Watanabe, 2006, Delayed gadolinium-enhanced MR to determine glycosaminoglycan concentration in reparative cartilage after autologous chondrocyte implantation: Preliminary results, Radiology, 239, 201, 10.1148\u002Fradiol.2383050173",{"doi":2983},"10.1148\u002Fradiol.2383050173",{"id":26,"text":2985,"url":26,"identifiers":2986},"Veronesi, 2013, Clinical use of bone marrow, bone marrow concentrate, and expanded bone marrow mesenchymal stem cells in cartilage disease, Stem Cells Dev, 22, 181, 10.1089\u002Fscd.2012.0373",{"doi":2987},"10.1089\u002Fscd.2012.0373",{"id":26,"text":2989,"url":26,"identifiers":2990},"Zhang, 2011, Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: reevaluation of critical factors for successful isolation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells from bone marrow and adipose tissue, J Cell Biochem, 112, 1206, 10.1002\u002Fjcb.23042",{"doi":2991},"10.1002\u002Fjcb.23042",{"id":26,"text":2993,"url":26,"identifiers":2994},"Roura, 2015, The role and potential of umbilical cord blood in an era of new therapies: A review, Stem Cell Res Ther, 6, 123, 10.1186\u002Fs13287-015-0113-2",{"doi":2995},"10.1186\u002Fs13287-015-0113-2",{"id":26,"text":2997,"url":26,"identifiers":2998},"Park, 2015, Cartilage repair by human umbilical cord blood-derived mesenchymal stem cells with different hydrogels in a rat model, J Orthop Res, 33, 1580, 10.1002\u002Fjor.22950",{"doi":2999},"10.1002\u002Fjor.22950",{"id":26,"text":3001,"url":26,"identifiers":3002},"Ha, 2015, Cartilage repair using composites of human umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel in a minipig model, Stem Cells Translational Medicine, 4, 1044, 10.5966\u002Fsctm.2014-0264",{"doi":3003},"10.5966\u002Fsctm.2014-0264",{"id":26,"text":3005,"url":26,"identifiers":3006},"Lee, 2014, Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo, Biochem Biophys Res Commun, 446, 983, 10.1016\u002Fj.bbrc.2014.03.051",{"doi":3007},"10.1016\u002Fj.bbrc.2014.03.051",{"id":26,"text":1053,"url":26,"identifiers":3009},{"doi":1055},{"id":26,"text":3011,"url":26,"identifiers":3012},"Sato, 2012, Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis, Arthritis Res Ther, 14, R31, 10.1186\u002Far3735",{"doi":3013},"10.1186\u002Far3735",{"id":26,"text":3015,"url":26,"identifiers":3016},"Jeong, 2013, Thrombospondin-2 secreted by human umbilical cord blood-derived mesenchymal stem cells promotes chondrogenic differentiation, Stem Cells, 31, 2136, 10.1002\u002Fstem.1471",{"doi":3017},"10.1002\u002Fstem.1471",{"id":26,"text":3019,"url":26,"identifiers":3020},"Brown, 2014, Temporal in vivo assessment of fresh osteochondral allograft transplants to the distal aspect of the femur by dGEMRIC (delayed gadolinium-enhanced MRI of cartilage) and zonal T2 mapping MRI, J Bone Joint Surg Am, 96, 564, 10.2106\u002FJBJS.K.01456",{"doi":3021},"10.2106\u002FJBJS.K.01456",{"id":26,"text":3023,"url":26,"identifiers":3024},"Mithoefer, 2005, The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study, J Bone Joint Surg Am, 87, 1911, 10.2106\u002FJBJS.D.02846",{"doi":3025},"10.2106\u002FJBJS.D.02846",{"id":26,"text":3027,"url":26,"identifiers":3028},"Williams, 2007, Microfracture: Indications, technique, and results, Instr Course Lect, 56, 419",{},{"id":26,"text":3030,"url":26,"identifiers":3031},"Filardo, 2013, Matrix-assisted autologous chondrocyte transplantation for cartilage regeneration in osteoarthritic knees: Results and failures at midterm follow-up, Am J Sports Med, 41, 95, 10.1177\u002F0363546512463675",{"doi":3032},"10.1177\u002F0363546512463675",{"id":3034,"createTime":3035,"updateTime":3036,"relativeEntities":3037,"slug":3038,"properties":3039,"entityType":792,"verifyStatus":25,"verifyTime":3035,"verifyNote":793,"syncStatus":28,"languages":3057,"translateLanguages":3058,"viewCount":36,"primaryUrl":3059,"fullTextUrl":26,"authors":3060,"publicationType":877,"publisherRelationship":3097,"citationCount":3128,"citationInfo":3129,"publishDate":3131,"publishYear":1966,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":3132,"isForceReanalyzing":1210},"d21a1baf-a8e7-402a-a881-545b6369e563","2024-10-04T11:16:53.309+00:00","2025-02-22T15:13:52.711+00:00",[],"Bone-Marrow-Derived-Mesenchymal-Stem-Cells-Derived-Exosomes-Promote-Survival-of-Retinal-Ganglion-Cells-Through-miRNA-Dependent-Mechanisms",{"mag":3040,"keywords":3042,"pmc":3043,"openalex":3045,"abstract":3047,"title":3050,"pm":3053,"doi":3055},{"VOID":3041},"2581455542",{"VI":777},{"VOID":3044},"5442835",{"VOID":3046},"W2581455542",{"EN":3048,"VI":3049},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC) have demonstrated significant neuroprotective and axogenic effects on RGC in both of the aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30–100 nm) containing proteins, mRNA and miRNA which can be delivered to nearby cells. The present study aimed to isolate exosomes from bone marrow-derived MSC (BMSC) and test them in a rat optic nerve crush (ONC) model. Treatment of primary retinal cultures with BMSC-exosomes demonstrated significant neuroprotective and neuritogenic effects. Twenty-one days after ONC and weekly intravitreal exosome injections; optical coherence tomography, electroretinography, and immunohistochemistry was performed. BMSC-derived exosomes promoted statistically significant survival of RGC and regeneration of their axons while partially preventing RGC axonal loss and RGC dysfunction. Exosomes successfully delivered their cargo into inner retinal layers and the effects were reliant on miRNA, demonstrated by the diminished therapeutic effects of exosomes derived from BMSC after knockdown of Argonaute-2, a key miRNA effector molecule. This study supports the use of BMSC-derived exosomes as a cell-free therapy for traumatic and degenerative ocular disease.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n               \u003Cjats:p>Mất tế bào thần kinh hạch võng mạc (RGC) và các sợi trục của chúng là một trong những nguyên nhân hàng đầu gây mù lòa, bao gồm các bệnh về mắt chấn thương (bệnh thần kinh thị giác) và thoái hóa (cườm nước). Mặc dù không có liệu pháp lâm sàng nào được sử dụng, tế bào gốc trung mô (MSC) đã chứng tỏ có tác dụng bảo vệ thần kinh và thúc đẩy sự hình thành sợi thần kinh đáng kể đối với RGC trong cả hai mô hình nêu trên. Bằng chứng gần đây cho thấy MSC tiết ra exosome, các túi màng bao gồm (30–100 nm) chứa protein, mRNA và miRNA có thể được chuyển đến các tế bào lân cận. Nghiên cứu hiện tại nhằm mục đích phân lập exosome từ MSC lấy từ tủy xương (BMSC) và thử nghiệm chúng trong mô hình nghiền dây thần kinh thị giác ở chuột (ONC). Việc điều trị các mô hình văn hóa võng mạc chính bằng exosome BMSC cho thấy tác dụng bảo vệ thần kinh và thúc đẩy hình thành sợi thần kinh đáng kể. Hai mươi mốt ngày sau ONC và tiêm thuốc vào thủy tinh thể hàng tuần; chụp ánh sáng đồng bộ quang học, điện sinh lý võng mạc và hóa miễn dịch đã được thực hiện. Exosome nguồn gốc từ BMSC đã thúc đẩy sự sống sót đáng kể của RGC và sự tái sinh các sợi trục của chúng trong khi một phần ngăn chặn mất mát sợi trục RGC và rối loạn chức năng RGC. Exosome đã thành công trong việc chuyển tải hàng hóa của chúng vào các lớp trong của võng mạc và các hiệu ứng phụ thuộc vào miRNA, được chứng minh bằng việc giảm hiệu ứng điều trị của các exosome lấy từ BMSC sau khi gạt bỏ Argonaute-2, một phân tử tác động miRNA quan trọng. Nghiên cứu này ủng hộ việc sử dụng exosome lấy từ BMSC như một liệu pháp không dựa trên tế bào cho căn bệnh mắt chấn thương và thoái hóa.\u003C\u002Fjats:p>",{"EN":3051,"VI":3052},"Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms","Exosome từ tế bào gốc trung mô lấy từ tủy xương thúc đẩy sự sống sót của tế bào thần kinh hạch võng mạc thông qua cơ chế phụ thuộc vào miRNA",{"VOID":3054},"28198592",{"VOID":3056},"10.1002\u002Fsctm.16-0428",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F6\u002F4\u002F1273\u002F6404678",[3061,3082],{"id":3062,"sortIndex":36,"researcher":26,"roles":3063,"affiliations":3064,"properties":3075},"2add27ce-3648-4b4d-ac20-82e4ac9407ee",[],[3065],{"id":3066,"sortIndex":36,"affiliation":3067,"properties":26},"e0f4ad01-3bdf-4b8a-ab3a-cd93328a641f",{"id":3068,"createTime":3069,"updateTime":3069,"relativeEntities":3070,"slug":3071,"properties":3072,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2fc4607b-4f5e-4255-aa5e-75b1628fd27f","2024-10-04T11:16:53.329+00:00",[],"Section-of-Retinal-Ganglion-Cell-Biology-Laboratory-of-Retinal-Cell-and-Molecular-Biology-National-Eye-Institute-National-Institutes-of-Health-Bethesda-Maryland-USA",{"title":3073},{"EN":3074},"Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA",{"openalex":3076,"orcid":3078,"title":3080},{"VOID":3077},"A5036095079",{"VOID":3079},"https:\u002F\u002Forcid.org\u002F0000-0001-5855-0097",{"EN":3081},"Ben Mead",{"id":3083,"sortIndex":115,"researcher":26,"roles":3084,"affiliations":3085,"properties":3092},"2929c47e-5591-4ec3-bf72-1228ebdce242",[],[3086],{"id":3087,"sortIndex":36,"affiliation":3088,"properties":26},"ff90e132-41c6-48a8-b905-4e412259132a",{"id":3068,"createTime":3069,"updateTime":3069,"relativeEntities":3089,"slug":3071,"properties":3090,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3091},{"EN":3074},{"openalex":3093,"title":3095},{"VOID":3094},"A5079651670",{"EN":3096},"Stanislav I. Tomarev",{"url":26,"publisher":3098,"properties":3123},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3099,"slug":663,"properties":3100,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3106,"manageAffiliations":3107,"indexDatabases":3108,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":3101,"issn":3102,"introduce":3103,"eissn":3104,"title":3105},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[3109,3116],{"id":742,"indexDatabase":3110,"url":755,"indexYears":756,"academicFieldIds":3115,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":3111,"label":3112,"description":3113,"key":752,"publicationTags":3114,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":3117,"url":738,"indexYears":26,"academicFieldIds":3122,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":3118,"label":3119,"description":3120,"key":734,"publicationTags":3121,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":3124,"pages":3125,"issue":3127},{"VOID":1954},{"VOID":3126},"1273-1285",{"VOID":1461},338,{"total":3128,"publishYear":26,"statisticByYear":3130},{"2017":52,"2018":239,"2019":257,"2020":517,"2021":44,"2022":254,"2023":282,"2024":402},"2017-04-01",[3133,3135,3139,3143,3147,3150,3154,3158,3162,3166,3170,3173,3177,3181,3185,3189,3193,3197,3201,3205,3209,3212,3216,3218,3222,3226,3230,3234,3237,3239,3243,3247,3251,3253,3257,3261,3265,3269,3273,3277,3281,3285,3289,3293,3297,3301,3305,3309,3313,3317,3321,3325,3329,3333,3337,3341,3345,3347,3351,3355,3359,3363,3367],{"id":26,"text":1995,"url":26,"identifiers":3134},{},{"id":26,"text":3136,"url":26,"identifiers":3137},"Zuk, 2001, Multilineage cells from human adipose tissue: Implications for cell-based therapies, Tissue Eng, 7, 211, 10.1089\u002F107632701300062859",{"doi":3138},"10.1089\u002F107632701300062859",{"id":26,"text":3140,"url":26,"identifiers":3141},"Gronthos, 2000, Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo, Proc Natl Acad Sci USA, 97, 13625, 10.1073\u002Fpnas.240309797",{"doi":3142},"10.1073\u002Fpnas.240309797",{"id":26,"text":3144,"url":26,"identifiers":3145},"Kogler, 2004, A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential, J Exp Med, 200, 123, 10.1084\u002Fjem.20040440",{"doi":3146},"10.1084\u002Fjem.20040440",{"id":26,"text":3148,"url":26,"identifiers":3149},"Berry, 2008, Regeneration of axons in the visual system, Restor Neurol Neurosci, 26, 147",{},{"id":26,"text":3151,"url":26,"identifiers":3152},"Mead, 2015, Stem cell treatment of degenerative eye disease, Stem Cell Res, 14, 243, 10.1016\u002Fj.scr.2015.02.003",{"doi":3153},"10.1016\u002Fj.scr.2015.02.003",{"id":26,"text":3155,"url":26,"identifiers":3156},"Mead, 2014, Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow and adipose-derived mesenchymal stem cells, PLoS One, 9, e109305, 10.1371\u002Fjournal.pone.0109305",{"doi":3157},"10.1371\u002Fjournal.pone.0109305",{"id":26,"text":3159,"url":26,"identifiers":3160},"Mead, 2014, Dental pulp stem cells, a paracrine-mediated therapy for the retina, Neural Regen Res, 9, 577, 10.4103\u002F1673-5374.130089",{"doi":3161},"10.4103\u002F1673-5374.130089",{"id":26,"text":3163,"url":26,"identifiers":3164},"Levkovitch-Verbin, 2010, Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection, Invest Ophthalmol Vis Sci, 51, 6394, 10.1167\u002Fiovs.09-4310",{"doi":3165},"10.1167\u002Fiovs.09-4310",{"id":26,"text":3167,"url":26,"identifiers":3168},"Mead, 2013, Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury, Invest Ophthalmol Vis Sci, 54, 7544, 10.1167\u002Fiovs.13-13045",{"doi":3169},"10.1167\u002Fiovs.13-13045",{"id":26,"text":3171,"url":26,"identifiers":3172},"Tan, 2015, The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat, Clin Interv Aging, 10, 487",{},{"id":26,"text":3174,"url":26,"identifiers":3175},"Zwart, 2009, Umbilical cord blood mesenchymal stromal cells are neuroprotective and promote regeneration in a rat optic tract model, Exp Neurol, 216, 439, 10.1016\u002Fj.expneurol.2008.12.028",{"doi":3176},"10.1016\u002Fj.expneurol.2008.12.028",{"id":26,"text":3178,"url":26,"identifiers":3179},"Mead, 2016, Mesenchymal stromal cell-mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma, Cytotherapy, 18, 487, 10.1016\u002Fj.jcyt.2015.12.002",{"doi":3180},"10.1016\u002Fj.jcyt.2015.12.002",{"id":26,"text":3182,"url":26,"identifiers":3183},"Emre, 2015, Neuroprotective effects of intravitreally transplanted adipose tissue and bone marrow-derived mesenchymal stem cells in an experimental ocular hypertension model, Cytotherapy, 10.1016\u002Fj.jcyt.2014.12.005",{"doi":3184},"10.1016\u002Fj.jcyt.2014.12.005",{"id":26,"text":3186,"url":26,"identifiers":3187},"Johnson, 2010, Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma, Invest Ophthalmol Vis Sci, 51, 2051, 10.1167\u002Fiovs.09-4509",{"doi":3188},"10.1167\u002Fiovs.09-4509",{"id":26,"text":3190,"url":26,"identifiers":3191},"Yu, 2006, Effects of bone marrow stromal cell injection in an experimental glaucoma model, Biochem Biophys Res Commun, 344, 1071, 10.1016\u002Fj.bbrc.2006.03.231",{"doi":3192},"10.1016\u002Fj.bbrc.2006.03.231",{"id":26,"text":3194,"url":26,"identifiers":3195},"Johnson, 2014, Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome, Brain, 10.1093\u002Fbrain\u002Fawt292",{"doi":3196},"10.1093\u002Fbrain\u002Fawt292",{"id":26,"text":3198,"url":26,"identifiers":3199},"Zhao, 2016, Wnt3a, a Protein secreted by mesenchymal stem cells is neuroprotective and promotes neurocognitive recovery following traumatic brain injury, Stem Cells, 34, 1263, 10.1002\u002Fstem.2310",{"doi":3200},"10.1002\u002Fstem.2310",{"id":26,"text":3202,"url":26,"identifiers":3203},"Johnson, 2010, Identification of barriers to retinal engraftment of transplanted stem cells, Invest Ophthalmol Vis Sci, 51, 960, 10.1167\u002Fiovs.09-3884",{"doi":3204},"10.1167\u002Fiovs.09-3884",{"id":26,"text":3206,"url":26,"identifiers":3207},"Pan, 1983, Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor, Cell, 33, 967, 10.1016\u002F0092-8674(83)90040-5",{"doi":3208},"10.1016\u002F0092-8674(83)90040-5",{"id":26,"text":3210,"url":26,"identifiers":3211},"Thery, 2006, Isolation and characterization of exosomes from cell culture supernatants and biological fluids, Curr Protoc Cell Biol, 3",{},{"id":26,"text":3213,"url":26,"identifiers":3214},"Kim, 2012, Proteomic analysis of microvesicles derived from human mesenchymal stem cells, J Proteome Res, 11, 839, 10.1021\u002Fpr200682z",{"doi":3215},"10.1021\u002Fpr200682z",{"id":26,"text":1610,"url":26,"identifiers":3217},{"doi":1612},{"id":26,"text":3219,"url":26,"identifiers":3220},"Kosaka, 2016, Versatile roles of extracellular vesicles in cancer, J Clin Invest, 126, 1163, 10.1172\u002FJCI81130",{"doi":3221},"10.1172\u002FJCI81130",{"id":26,"text":3223,"url":26,"identifiers":3224},"Heusermann, 2016, Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER, J Cell Biol, 213, 173, 10.1083\u002Fjcb.201506084",{"doi":3225},"10.1083\u002Fjcb.201506084",{"id":26,"text":3227,"url":26,"identifiers":3228},"Lai, 2010, Derivation and characterization of human fetal MSCs: An alternative cell source for large-scale production of cardioprotective microparticles, J Mol Cell Cardiol, 48, 1215, 10.1016\u002Fj.yjmcc.2009.12.021",{"doi":3229},"10.1016\u002Fj.yjmcc.2009.12.021",{"id":26,"text":3231,"url":26,"identifiers":3232},"Chen, 2010, Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs, Nucleic Acids Res, 38, 215, 10.1093\u002Fnar\u002Fgkp857",{"doi":3233},"10.1093\u002Fnar\u002Fgkp857",{"id":26,"text":3235,"url":26,"identifiers":3236},"Timmers, 2007, Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium, Stem Cell Res, 1, 129, 10.1016\u002Fj.scr.2008.02.002",{"doi":1569},{"id":26,"text":2448,"url":26,"identifiers":3238},{"doi":1593},{"id":26,"text":3240,"url":26,"identifiers":3241},"Arslan, 2013, Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K\u002FAkt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia\u002Freperfusion injury, Stem Cell Res, 10, 301, 10.1016\u002Fj.scr.2013.01.002",{"doi":3242},"10.1016\u002Fj.scr.2013.01.002",{"id":26,"text":3244,"url":26,"identifiers":3245},"Katsuda, 2015, Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair, Stem Cell Res Ther, 6, 212, 10.1186\u002Fs13287-015-0214-y",{"doi":3246},"10.1186\u002Fs13287-015-0214-y",{"id":26,"text":3248,"url":26,"identifiers":3249},"Zhang, 2016, Exosomes derived from mesenchymal stromal cells promote axonal growth of cortical neurons, Mol Neurobiol, 10.1007\u002Fs12035-016-9851-0",{"doi":3250},"10.1007\u002Fs12035-016-9851-0",{"id":26,"text":1599,"url":26,"identifiers":3252},{"doi":1601},{"id":26,"text":3254,"url":26,"identifiers":3255},"Zhang, 2015, Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury, J Neurosurg, 122, 856, 10.3171\u002F2014.11.JNS14770",{"doi":3256},"10.3171\u002F2014.11.JNS14770",{"id":26,"text":3258,"url":26,"identifiers":3259},"Nakano, 2016, Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes, Sci Rep, 6, 10.1038\u002Fsrep24805",{"doi":3260},"10.1038\u002Fsrep24805",{"id":26,"text":3262,"url":26,"identifiers":3263},"Sullivan, 1988, Structure and utilization of tubulin isotypes, Ann Rev of Cell Biolo, 4, 687, 10.1146\u002Fannurev.cb.04.110188.003351",{"doi":3264},"10.1146\u002Fannurev.cb.04.110188.003351",{"id":26,"text":3266,"url":26,"identifiers":3267},"Suggate, 2009, Optimisation of siRNA-mediated RhoA silencing in neuronal cultures, Mol Cell Neurosci, 40, 451, 10.1016\u002Fj.mcn.2009.01.004",{"doi":3268},"10.1016\u002Fj.mcn.2009.01.004",{"id":26,"text":3270,"url":26,"identifiers":3271},"Berry, 1996, Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve, J Neurocytol, 25, 147, 10.1007\u002FBF02284793",{"doi":3272},"10.1007\u002FBF02284793",{"id":26,"text":3274,"url":26,"identifiers":3275},"Mead, 2014, Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts, PLoS One, 9, e110612, 10.1371\u002Fjournal.pone.0110612",{"doi":3276},"10.1371\u002Fjournal.pone.0110612",{"id":26,"text":3278,"url":26,"identifiers":3279},"Faul, 2007, G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences, Behav Res Methods, 39, 175, 10.3758\u002FBF03193146",{"doi":3280},"10.3758\u002FBF03193146",{"id":26,"text":3282,"url":26,"identifiers":3283},"Ching, 2015, The role of exosomes in peripheral nerve regeneration, Neural Regen Res, 10, 743, 10.4103\u002F1673-5374.156968",{"doi":3284},"10.4103\u002F1673-5374.156968",{"id":26,"text":3286,"url":26,"identifiers":3287},"Sun, 2016, Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell, Cytotherapy, 18, 413, 10.1016\u002Fj.jcyt.2015.11.018",{"doi":3288},"10.1016\u002Fj.jcyt.2015.11.018",{"id":26,"text":3290,"url":26,"identifiers":3291},"Sun, 2013, Exosomes are endogenous nanoparticles that can deliver biological information between cells, Adv Drug Deliv Rev, 65, 342, 10.1016\u002Fj.addr.2012.07.002",{"doi":3292},"10.1016\u002Fj.addr.2012.07.002",{"id":26,"text":3294,"url":26,"identifiers":3295},"Sinha, 2016, Cortactin promotes exosome secretion by controlling branched actin dynamics, J Cell Biol, 214, 197, 10.1083\u002Fjcb.201601025",{"doi":3296},"10.1083\u002Fjcb.201601025",{"id":26,"text":3298,"url":26,"identifiers":3299},"Chiu, 2016, A single-cell assay for time lapse studies of exosome secretion and cell behaviors, Small, 12, 3658, 10.1002\u002Fsmll.201600725",{"doi":3300},"10.1002\u002Fsmll.201600725",{"id":26,"text":3302,"url":26,"identifiers":3303},"Lorber, 2008, Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting, J Neurosci Res, 86, 894, 10.1002\u002Fjnr.21545",{"doi":3304},"10.1002\u002Fjnr.21545",{"id":26,"text":3306,"url":26,"identifiers":3307},"Douglas, 2009, Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth, Brain, 132, 3102, 10.1093\u002Fbrain\u002Fawp240",{"doi":3308},"10.1093\u002Fbrain\u002Fawp240",{"id":26,"text":3310,"url":26,"identifiers":3311},"Lopez-Verrilli, 2016, Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth, Neuroscience, 320, 129, 10.1016\u002Fj.neuroscience.2016.01.061",{"doi":3312},"10.1016\u002Fj.neuroscience.2016.01.061",{"id":26,"text":3314,"url":26,"identifiers":3315},"Berkelaar, 1994, Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats, J Neurosci, 14, 4368, 10.1523\u002FJNEUROSCI.14-07-04368.1994",{"doi":3316},"10.1523\u002FJNEUROSCI.14-07-04368.1994",{"id":26,"text":3318,"url":26,"identifiers":3319},"Mesentier-Louro, 2014, Distribution of mesenchymal stem cells and effects on neuronal survival and axon regeneration after optic nerve crush and cell therapy, PLoS One, 9, e110722, 10.1371\u002Fjournal.pone.0110722",{"doi":3320},"10.1371\u002Fjournal.pone.0110722",{"id":26,"text":3322,"url":26,"identifiers":3323},"Mead, 2016, Evaluating retinal ganglion cell loss and dysfunction, Exp Eye Res, 151, 96, 10.1016\u002Fj.exer.2016.08.006",{"doi":3324},"10.1016\u002Fj.exer.2016.08.006",{"id":26,"text":3326,"url":26,"identifiers":3327},"Duan, 2015, Subtype-specific regeneration of retinal ganglion cells following axotomy: Effects of osteopontin and mTOR signaling, Neuron, 85, 1244, 10.1016\u002Fj.neuron.2015.02.017",{"doi":3328},"10.1016\u002Fj.neuron.2015.02.017",{"id":26,"text":3330,"url":26,"identifiers":3331},"Ha, 2014, Regulation of microRNA biogenesis, Nat Rev Mol Cell Biol, 15, 509, 10.1038\u002Fnrm3838",{"doi":3332},"10.1038\u002Fnrm3838",{"id":26,"text":3334,"url":26,"identifiers":3335},"Guduric-Fuchs, 2012, Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types, BMC Genomics, 13, 357, 10.1186\u002F1471-2164-13-357",{"doi":3336},"10.1186\u002F1471-2164-13-357",{"id":26,"text":3338,"url":26,"identifiers":3339},"Baglio, 2015, Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species, Stem Cell Res Ther, 6, 127, 10.1186\u002Fs13287-015-0116-z",{"doi":3340},"10.1186\u002Fs13287-015-0116-z",{"id":26,"text":3342,"url":26,"identifiers":3343},"Qian, 2016, Exosomal microRNAs derived from umbilical mesenchymal stem cells inhibit Hepatitis C virus infection, Stem Cells Transl Med, 10.5966\u002Fsctm.2015-0348",{"doi":3344},"10.5966\u002Fsctm.2015-0348",{"id":26,"text":2455,"url":26,"identifiers":3346},{"doi":2457},{"id":26,"text":3348,"url":26,"identifiers":3349},"Park, 2008, Promoting axon regeneration in the adult CNS by modulation of the PTEN\u002FmTOR pathway, Science, 322, 963, 10.1126\u002Fscience.1161566",{"doi":3350},"10.1126\u002Fscience.1161566",{"id":26,"text":3352,"url":26,"identifiers":3353},"Berry, 2016, Prospects for mTOR-mediated functional repair after central nervous system trauma, Neurobiol Dis, 85, 99, 10.1016\u002Fj.nbd.2015.10.002",{"doi":3354},"10.1016\u002Fj.nbd.2015.10.002",{"id":26,"text":3356,"url":26,"identifiers":3357},"Meng, 2007, MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer, Gastroenterology, 133, 647, 10.1053\u002Fj.gastro.2007.05.022",{"doi":3358},"10.1053\u002Fj.gastro.2007.05.022",{"id":26,"text":3360,"url":26,"identifiers":3361},"Katakowski, 2013, Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth, Cancer Lett, 335, 201, 10.1016\u002Fj.canlet.2013.02.019",{"doi":3362},"10.1016\u002Fj.canlet.2013.02.019",{"id":26,"text":3364,"url":26,"identifiers":3365},"Koprivica, 2005, EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans, Science, 310, 106, 10.1126\u002Fscience.1115462",{"doi":3366},"10.1126\u002Fscience.1115462",{"id":26,"text":3368,"url":26,"identifiers":3369},"Gu, 2016, Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway, Mol Med Rep, 10.3892\u002Fmmr.2016.5625",{"doi":3370},"10.3892\u002Fmmr.2016.5625",{"id":3372,"createTime":3373,"updateTime":3374,"relativeEntities":3375,"slug":3376,"properties":3377,"entityType":792,"verifyStatus":25,"verifyTime":3373,"verifyNote":793,"syncStatus":28,"languages":3395,"translateLanguages":3396,"viewCount":36,"primaryUrl":3397,"fullTextUrl":26,"authors":3398,"publicationType":877,"publisherRelationship":3664,"citationCount":394,"citationInfo":3695,"publishDate":3697,"publishYear":916,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":3698,"isForceReanalyzing":1210},"b9d53bfc-6c6a-4aca-92f5-a4d7bc02031a","2024-09-30T23:42:58.150+00:00","2025-02-22T15:14:49.669+00:00",[],"Human-Mesenchymal-Stem-Cell-Transfusion-Is-Safe-and-Improves-Liver-Function-in-Acute-on-Chronic-Liver-Failure-Patients",{"mag":3378,"keywords":3380,"pmc":3381,"openalex":3383,"abstract":3385,"title":3388,"pm":3391,"doi":3393},{"VOID":3379},"2143119387",{"VI":777},{"VOID":3382},"3659658",{"VOID":3384},"W2143119387",{"EN":3386,"VI":3387},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Acute-on-chronic liver failure (ACLF) is a severe, life-threatening complication, and new and efficient therapeutic strategies for liver failure are urgently needed. Mesenchymal stem cell (MSC) transfusions have been shown to reverse fulminant hepatic failure in mice and to improve liver function in patients with end-stage liver diseases. We assessed the safety and initial efficacy of umbilical cord-derived MSC (UC-MSC) transfusions for ACLF patients associated with hepatitis B virus (HBV) infection. A total of 43 ACLF patients were enrolled for this open-labeled and controlled study; 24 patients were treated with UC-MSCs, and 19 patients were treated with saline as controls. UC-MSC therapy was given three times at 4-week intervals. The liver function, adverse events, and survival rates were evaluated during the 48-week or 72-week follow-up period. No significant side effects were observed during the trial. The UC-MSC transfusions significantly increased the survival rates in ACLF patients; reduced the model for end-stage liver disease scores; increased serum albumin, cholinesterase, and prothrombin activity; and increased platelet counts. Serum total bilirubin and alanine aminotransferase levels were significantly decreased after the UC-MSC transfusions. UC-MSC transfusions are safe in the clinic and may serve as a novel therapeutic approach for HBV-associated ACLF patients.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n               \u003Cjats:p>Suy gan cấp trên nền mãn tính (ACLF) là một biến chứng nghiêm trọng, đe dọa tính mạng, và cần thiết phải có các chiến lược điều trị mới và hiệu quả cho suy gan. Việc truyền tế bào gốc trung mô (MSC) đã được chứng minh là có khả năng đảo ngược tình trạng suy gan cấp tính ở chuột và cải thiện chức năng gan ở bệnh nhân có bệnh gan giai đoạn cuối. Chúng tôi đã đánh giá độ an toàn và hiệu quả ban đầu của việc truyền MSC lấy từ dây rốn (UC-MSC) cho bệnh nhân ACLF liên quan đến nhiễm vi rút viêm gan B (HBV). Tổng cộng 43 bệnh nhân ACLF đã được tham gia vào nghiên cứu này, một nghiên cứu mở và có kiểm soát; 24 bệnh nhân được điều trị bằng UC-MSCs, và 19 bệnh nhân còn lại được điều trị bằng dung dịch muối sinh lý như nhóm chứng. Việc điều trị bằng UC-MSC được thực hiện ba lần tại các khoảng cách 4 tuần. Chức năng gan, các sự kiện bất lợi, và tỷ lệ sống sót đã được đánh giá trong thời gian theo dõi 48 tuần hoặc 72 tuần. Không có tác dụng phụ đáng kể nào được quan sát trong quá trình thử nghiệm. Việc truyền UC-MSC đã làm tăng đáng kể tỷ lệ sống sót ở bệnh nhân ACLF; giảm điểm số mô hình cho bệnh gan giai đoạn cuối; tăng nồng độ albumin huyết thanh, cholinesterase, và hoạt tính prothrombin; và tăng số lượng tiểu cầu. Mức bilirubin toàn phần và alanine aminotransferase trong huyết thanh đã giảm đáng kể sau khi truyền UC-MSC. Việc truyền UC-MSC là an toàn trong lâm sàng và có thể là một phương pháp điều trị mới cho bệnh nhân ACLF liên quan đến HBV.\u003C\u002Fjats:p>",{"EN":3389,"VI":3390},"Human Mesenchymal Stem Cell Transfusion Is Safe and Improves Liver Function in Acute-on-Chronic Liver Failure Patients","Truyền tế bào gốc trung mô người an toàn và cải thiện chức năng gan ở bệnh nhân suy gan cấp trên nền mãn tính",{"VOID":3392},"23197664",{"VOID":3394},"10.5966\u002Fsctm.2012-0034",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F1\u002F10\u002F725-731\u002F6385503",[3399,3421,3438,3455,3470,3487,3504,3521,3538,3566,3581,3598,3615,3632,3649],{"id":3400,"sortIndex":111,"researcher":26,"roles":3401,"affiliations":3402,"properties":3414},"931ed19e-c5a7-426d-9bde-95de6f2d54ba",[],[3403],{"id":3404,"sortIndex":36,"affiliation":3405,"properties":26},"4f25ebd7-b5a3-4f47-a637-6aade526eb84",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3409,"slug":3410,"properties":3411,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"63e1b68b-4fff-4bc9-92b4-a29853b8c6da","2024-01-16T17:37:18.384+00:00","2024-09-30T23:42:58.172+00:00",[],"Research-Center-for-Biological-Therapy-Institute-of-Translational-Hepatology-Beijing-302-Hospital-Beijing-China",{"title":3412},{"VI":3413},"Research Center for Biological Therapy, Institute of Translational Hepatology,  Beijing 302 Hospital, Beijing, China",{"openalex":3415,"orcid":3417,"title":3419},{"VOID":3416},"A5042360471",{"VOID":3418},"https:\u002F\u002Forcid.org\u002F0009-0001-8318-6888",{"EN":3420},"Junliang Fu",{"id":3422,"sortIndex":103,"researcher":26,"roles":3423,"affiliations":3424,"properties":3431},"ca05eb99-23e1-430b-8980-107f2984b6d3",[],[3425],{"id":3426,"sortIndex":36,"affiliation":3427,"properties":26},"bb104d5b-180b-4bd9-9704-028871b33ca1",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3428,"slug":3410,"properties":3429,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3430},{"VI":3413},{"openalex":3432,"orcid":3434,"title":3436},{"VOID":3433},"A5100740368",{"VOID":3435},"https:\u002F\u002Forcid.org\u002F0000-0001-5630-2081",{"EN":3437},"Lei Jin",{"id":3439,"sortIndex":52,"researcher":26,"roles":3440,"affiliations":3441,"properties":3448},"90b059f4-d2fa-4263-bb2d-a6d216d4eb88",[],[3442],{"id":3443,"sortIndex":36,"affiliation":3444,"properties":26},"9ad6a856-e1f0-4ee5-8dba-3ce3d4c9eb1d",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3445,"slug":3410,"properties":3446,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3447},{"VI":3413},{"openalex":3449,"orcid":3451,"title":3453},{"VOID":3450},"A5103103617",{"VOID":3452},"https:\u002F\u002Forcid.org\u002F0000-0003-0156-0766",{"EN":3454},"Sa Lv",{"id":3456,"sortIndex":116,"researcher":26,"roles":3457,"affiliations":3458,"properties":3465},"265db46c-d6fd-4259-8ec7-d600305b52de",[],[3459],{"id":3460,"sortIndex":36,"affiliation":3461,"properties":26},"2530850a-dc6e-43d4-a22d-0d5efb723597",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3462,"slug":3410,"properties":3463,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3464},{"VI":3413},{"openalex":3466,"title":3468},{"VOID":3467},"A5100552465",{"EN":3469},"Wei-Ping He",{"id":3471,"sortIndex":50,"researcher":26,"roles":3472,"affiliations":3473,"properties":3480},"9546648f-c4d0-41da-96d8-3944219ec967",[],[3474],{"id":3475,"sortIndex":36,"affiliation":3476,"properties":26},"f7165d40-a84e-449f-9638-3599ef494c13",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3477,"slug":3410,"properties":3478,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3479},{"VI":3413},{"openalex":3481,"orcid":3483,"title":3485},{"VOID":3482},"A5100443517",{"VOID":3484},"https:\u002F\u002Forcid.org\u002F0000-0001-5065-9557",{"EN":3486},"Liming Chen",{"id":3488,"sortIndex":298,"researcher":26,"roles":3489,"affiliations":3490,"properties":3497},"1857695b-c256-4f90-860d-eb67ba1fc38a",[],[3491],{"id":3492,"sortIndex":36,"affiliation":3493,"properties":26},"8d4a054b-a2da-4b89-953e-068a0d41514b",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3494,"slug":3410,"properties":3495,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3496},{"VI":3413},{"openalex":3498,"orcid":3500,"title":3502},{"VOID":3499},"A5100704638",{"VOID":3501},"https:\u002F\u002Forcid.org\u002F0000-0002-8043-6685",{"EN":3503},"Fu‐Sheng Wang",{"id":3505,"sortIndex":114,"researcher":26,"roles":3506,"affiliations":3507,"properties":3514},"4c99b767-6dce-4e09-8900-13f6ec627f39",[],[3508],{"id":3509,"sortIndex":36,"affiliation":3510,"properties":26},"204206ff-fe95-43fc-9b59-b154ef807e40",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3511,"slug":3410,"properties":3512,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3513},{"VI":3413},{"openalex":3515,"orcid":3517,"title":3519},{"VOID":3516},"A5044690971",{"VOID":3518},"https:\u002F\u002Forcid.org\u002F0000-0002-4180-7754",{"EN":3520},"Ruonan Xu",{"id":3522,"sortIndex":158,"researcher":26,"roles":3523,"affiliations":3524,"properties":3531},"1fd4ed25-9d13-4cd5-900c-5d742d4766dc",[],[3525],{"id":3526,"sortIndex":36,"affiliation":3527,"properties":26},"aad91d17-3c31-40dd-b176-eb3d8a927f3c",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3528,"slug":3410,"properties":3529,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3530},{"VI":3413},{"openalex":3532,"orcid":3534,"title":3536},{"VOID":3533},"A5103231932",{"VOID":3535},"https:\u002F\u002Forcid.org\u002F0000-0002-4891-6689",{"EN":3537},"Jianfei Shi",{"id":3539,"sortIndex":36,"researcher":26,"roles":3540,"affiliations":3541,"properties":3559},"5a683d79-1e2d-4077-b985-cfbe239204dd",[],[3542,3553],{"id":3543,"sortIndex":115,"affiliation":3544,"properties":26},"57172e6f-8e24-4a11-81cb-48e35dc7f03f",{"id":3545,"createTime":3546,"updateTime":3547,"relativeEntities":3548,"slug":3549,"properties":3550,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"ac36bfd6-11f2-4a6d-9351-ef6395521c8a","2023-12-11T19:54:54.461+00:00","2024-09-30T23:42:58.198+00:00",[],"Research-Center-for-Liver-Transplantation-Beijing-302-Hospital-Beijing-China",{"title":3551},{"VI":3552},"Research Center for Liver Transplantation, Beijing 302 Hospital, Beijing, China",{"id":3554,"sortIndex":36,"affiliation":3555,"properties":26},"8af62545-b1ef-4495-aa29-2c98390a7297",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3556,"slug":3410,"properties":3557,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3558},{"VI":3413},{"openalex":3560,"orcid":3562,"title":3564},{"VOID":3561},"A5101540906",{"VOID":3563},"https:\u002F\u002Forcid.org\u002F0000-0002-9905-6316",{"EN":3565},"Ming Shi",{"id":3567,"sortIndex":53,"researcher":26,"roles":3568,"affiliations":3569,"properties":3576},"3f8aac51-3398-4842-af2a-21fc0be5ea3c",[],[3570],{"id":3571,"sortIndex":36,"affiliation":3572,"properties":26},"2c296be5-28c8-4eef-8c72-64adebeccb9f",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3573,"slug":3410,"properties":3574,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3575},{"VI":3413},{"openalex":3577,"title":3579},{"VOID":3578},"A5100937454",{"EN":3580},"Hua Geng",{"id":3582,"sortIndex":135,"researcher":26,"roles":3583,"affiliations":3584,"properties":3591},"505d5757-6479-418e-881d-03640d16947f",[],[3585],{"id":3586,"sortIndex":36,"affiliation":3587,"properties":26},"11c291ce-1c24-4aad-be76-368292a0b302",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3588,"slug":3410,"properties":3589,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3590},{"VI":3413},{"openalex":3592,"orcid":3594,"title":3596},{"VOID":3593},"A5100656439",{"VOID":3595},"https:\u002F\u002Forcid.org\u002F0000-0002-5311-7021",{"EN":3597},"Aimin Zhang",{"id":3599,"sortIndex":162,"researcher":26,"roles":3600,"affiliations":3601,"properties":3608},"bb776e0d-8f0a-40de-b40d-af6fbe5343d4",[],[3602],{"id":3603,"sortIndex":36,"affiliation":3604,"properties":26},"abd30daa-2b6f-4708-be70-3ee98fda7996",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3605,"slug":3410,"properties":3606,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3607},{"VI":3413},{"openalex":3609,"orcid":3611,"title":3613},{"VOID":3610},"A5013521451",{"VOID":3612},"https:\u002F\u002Forcid.org\u002F0000-0002-1778-269X",{"EN":3614},"Zhengsheng Zou",{"id":3616,"sortIndex":356,"researcher":26,"roles":3617,"affiliations":3618,"properties":3625},"a69696c6-df5f-4e14-9cbf-ce62a9117ee8",[],[3619],{"id":3620,"sortIndex":36,"affiliation":3621,"properties":26},"1d2bb61f-de97-4a28-bb33-3f1858cfe4a9",{"id":3545,"createTime":3546,"updateTime":3547,"relativeEntities":3622,"slug":3549,"properties":3623,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3624},{"VI":3552},{"openalex":3626,"orcid":3628,"title":3630},{"VOID":3627},"A5102000296",{"VOID":3629},"https:\u002F\u002Forcid.org\u002F0000-0003-1048-104X",{"EN":3631},"Zhenwen Liu",{"id":3633,"sortIndex":115,"researcher":26,"roles":3634,"affiliations":3635,"properties":3642},"d2bf4785-ed8f-4892-b448-6be4b716bb46",[],[3636],{"id":3637,"sortIndex":36,"affiliation":3638,"properties":26},"9c7ce697-fc18-4573-be6a-a3fe2f6d897f",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3639,"slug":3410,"properties":3640,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3641},{"VI":3413},{"openalex":3643,"orcid":3645,"title":3647},{"VOID":3644},"A5100459115",{"VOID":3646},"https:\u002F\u002Forcid.org\u002F0000-0002-3544-1389",{"EN":3648},"Zheng Zhang",{"id":3650,"sortIndex":59,"researcher":26,"roles":3651,"affiliations":3652,"properties":3659},"86f253af-1db0-453c-826d-fbfd3505b9c3",[],[3653],{"id":3654,"sortIndex":36,"affiliation":3655,"properties":26},"25b6053c-ed10-4c09-88c1-928ca48207f8",{"id":3406,"createTime":3407,"updateTime":3408,"relativeEntities":3656,"slug":3410,"properties":3657,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3658},{"VI":3413},{"openalex":3660,"title":3662},{"VOID":3661},"A5100558669",{"EN":3663},"Hu Lin",{"url":26,"publisher":3665,"properties":3690},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3666,"slug":663,"properties":3667,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3673,"manageAffiliations":3674,"indexDatabases":3675,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":3668,"issn":3669,"introduce":3670,"eissn":3671,"title":3672},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[3676,3683],{"id":742,"indexDatabase":3677,"url":755,"indexYears":756,"academicFieldIds":3682,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":3678,"label":3679,"description":3680,"key":752,"publicationTags":3681,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":3684,"url":738,"indexYears":26,"academicFieldIds":3689,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":3685,"label":3686,"description":3687,"key":734,"publicationTags":3688,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":3691,"pages":3692,"issue":3694},{"VOID":906},{"VOID":3693},"725-731",{"VOID":1465},{"total":394,"publishYear":26,"statisticByYear":3696},{"2013":50,"2014":50,"2015":285,"2016":237,"2017":396,"2018":240,"2019":252,"2020":125,"2021":168,"2022":252,"2023":241,"2024":103},"2012-10-01",[3699,3703,3707,3711,3715,3717,3721,3723,3727,3729,3731,3735,3739,3743,3747,3751,3754,3758,3762,3766,3769,3773,3777,3781,3785,3789,3793,3797,3801,3805,3809],{"id":26,"text":3700,"url":26,"identifiers":3701},"Bernuau, 1986, Fulminant and subfulminant liver failure: Definitions and causes, Semin Liver Dis, 6, 97, 10.1055\u002Fs-2008-1040593",{"doi":3702},"10.1055\u002Fs-2008-1040593",{"id":26,"text":3704,"url":26,"identifiers":3705},"Farci, 1996, Hepatitis C virus-associated fulminant hepatic failure, N Engl J Med, 335, 631, 10.1056\u002FNEJM199608293350904",{"doi":3706},"10.1056\u002FNEJM199608293350904",{"id":26,"text":3708,"url":26,"identifiers":3709},"Navarro, 2006, Drug-related hepatotoxicity, N Engl J Med, 35, 731, 10.1056\u002FNEJMra052270",{"doi":3710},"10.1056\u002FNEJMra052270",{"id":26,"text":3712,"url":26,"identifiers":3713},"Sarin, 2009, Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the study of the liver (APASL), Hepatol Int, 3, 269, 10.1007\u002Fs12072-008-9106-x",{"doi":3714},"10.1007\u002Fs12072-008-9106-x",{"id":26,"text":2394,"url":26,"identifiers":3716},{"doi":2396},{"id":26,"text":3718,"url":26,"identifiers":3719},"Lee, 2004, In vitro hepatic differentiation of human mesenchymal stem cells, Hepatology, 40, 1275, 10.1002\u002Fhep.20469",{"doi":3720},"10.1002\u002Fhep.20469",{"id":26,"text":1666,"url":26,"identifiers":3722},{"doi":1668},{"id":26,"text":3724,"url":26,"identifiers":3725},"Shi, 2011, Immunomodulatory properties and therapeutic application of mesenchymal stem cells, Clin Exp Immunol, 164, 1, 10.1111\u002Fj.1365-2249.2011.04327.x",{"doi":3726},"10.1111\u002Fj.1365-2249.2011.04327.x",{"id":26,"text":1061,"url":26,"identifiers":3728},{"doi":1063},{"id":26,"text":2471,"url":26,"identifiers":3730},{"doi":2473},{"id":26,"text":3732,"url":26,"identifiers":3733},"Rabani, 2010, Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression, Cell Biol Int, 34, 601, 10.1042\u002FCBI20090386",{"doi":3734},"10.1042\u002FCBI20090386",{"id":26,"text":3736,"url":26,"identifiers":3737},"Chang, 2009, Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis, Life Sci, 85, 517, 10.1016\u002Fj.lfs.2009.08.003",{"doi":3738},"10.1016\u002Fj.lfs.2009.08.003",{"id":26,"text":3740,"url":26,"identifiers":3741},"Kuo, 2008, Stem cell therapy for liver disease: Parameters governing the success of using bone marrow mesenchymal stem cells, Gastroenterology, 134, 2111, 10.1053\u002Fj.gastro.2008.03.015",{"doi":3742},"10.1053\u002Fj.gastro.2008.03.015",{"id":26,"text":3744,"url":26,"identifiers":3745},"van Poll, 2008, Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo, Hepatology, 47, 1634, 10.1002\u002Fhep.22236",{"doi":3746},"10.1002\u002Fhep.22236",{"id":26,"text":3748,"url":26,"identifiers":3749},"Terai, 2006, Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy, Stem Cells, 24, 2292, 10.1634\u002Fstemcells.2005-0542",{"doi":3750},"10.1634\u002Fstemcells.2005-0542",{"id":26,"text":3752,"url":26,"identifiers":3753},"Mohamadnejad, 2007, Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis, Arch Iran Med, 10, 459",{},{"id":26,"text":3755,"url":26,"identifiers":3756},"Kharaziha, 2009, Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A phase I-II clinical trial, Eur J Gastroenterol Hepatol, 21, 1199, 10.1097\u002FMEG.0b013e32832a1f6c",{"doi":3757},"10.1097\u002FMEG.0b013e32832a1f6c",{"id":26,"text":3759,"url":26,"identifiers":3760},"Zhang, 2012, Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients, J Gastroenterol Hepatol, 27, 112, 10.1111\u002Fj.1440-1746.2011.07024.x",{"doi":3761},"10.1111\u002Fj.1440-1746.2011.07024.x",{"id":26,"text":3763,"url":26,"identifiers":3764},"Peng, 2011, Autologous bone mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: Short-term and long-term outcomes, Hepatology, 54, 820, 10.1002\u002Fhep.24434",{"doi":3765},"10.1002\u002Fhep.24434",{"id":26,"text":3767,"url":26,"identifiers":3768},"Lu, 2006, Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials, Haematologica, 91, 1017",{},{"id":26,"text":3770,"url":26,"identifiers":3771},"Garg, 2012, Granulocyte-colony stimulating factor mobilizes CD34+ cells and improves survival of patients with acute-on-chronic liver failure, Gastroenterology, 142, 505, 10.1053\u002Fj.gastro.2011.11.027",{"doi":3772},"10.1053\u002Fj.gastro.2011.11.027",{"id":26,"text":3774,"url":26,"identifiers":3775},"Zhong, 2010, deficient proliferation of bone marrow-derived mesenchymal stem cells in patients with chronic hepatitis B viral infections and cirrhosis of the liver, Dig Dis Sci, 55, 438, 10.1007\u002Fs10620-009-0733-4",{"doi":3776},"10.1007\u002Fs10620-009-0733-4",{"id":26,"text":3778,"url":26,"identifiers":3779},"Jung, 2009, Effect of human umbilical cord blood-derived mesenchymal stem cells in a cirrhotic rat model, Liver Int, 29, 898, 10.1111\u002Fj.1478-3231.2009.02031.x",{"doi":3780},"10.1111\u002Fj.1478-3231.2009.02031.x",{"id":26,"text":3782,"url":26,"identifiers":3783},"Tsai, 2009, The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis, Liver Transpl, 15, 484, 10.1002\u002Flt.21715",{"doi":3784},"10.1002\u002Flt.21715",{"id":26,"text":3786,"url":26,"identifiers":3787},"Hong, 2005, In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells, Biochem Biophys Res Commun, 330, 1153, 10.1016\u002Fj.bbrc.2005.03.086",{"doi":3788},"10.1016\u002Fj.bbrc.2005.03.086",{"id":26,"text":3790,"url":26,"identifiers":3791},"Aurich, 2007, Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers, Gut, 56, 405, 10.1136\u002Fgut.2005.090050",{"doi":3792},"10.1136\u002Fgut.2005.090050",{"id":26,"text":3794,"url":26,"identifiers":3795},"Yu, 2010, Antifibrotic effect of hepatocyte growth factor-expressing mesenchymal stem cells in small-for-size liver transplant rats, Stem Cells Dev, 19, 903, 10.1089\u002Fscd.2009.0254",{"doi":3796},"10.1089\u002Fscd.2009.0254",{"id":26,"text":3798,"url":26,"identifiers":3799},"Sato, 2005, Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion, Blood, 106, 756, 10.1182\u002Fblood-2005-02-0572",{"doi":3800},"10.1182\u002Fblood-2005-02-0572",{"id":26,"text":3802,"url":26,"identifiers":3803},"Friedman, 2007, Umbilical cord mesenchymal stem cells: Adjuvants for human cell transplantation, Biol Blood Marrow Transplant, 13, 1477, 10.1016\u002Fj.bbmt.2007.08.048",{"doi":3804},"10.1016\u002Fj.bbmt.2007.08.048",{"id":26,"text":3806,"url":26,"identifiers":3807},"Schinköthe, 2008, In vitro secreting profile of human mesenchymal stem cells, Stem Cells Dev, 17, 199, 10.1089\u002Fscd.2007.0175",{"doi":3808},"10.1089\u002Fscd.2007.0175",{"id":26,"text":3810,"url":26,"identifiers":3811},"Fong, 2012, Human umbilical cord Wharton's jelly stem cells and its conditioned medium support hematopoietic stem cell expansion ex vivo, J Cell Biochem, 113, 658, 10.1002\u002Fjcb.23395",{"doi":3812},"10.1002\u002Fjcb.23395",{"id":3814,"createTime":3815,"updateTime":3816,"relativeEntities":3817,"slug":3818,"properties":3819,"entityType":792,"verifyStatus":25,"verifyTime":3815,"verifyNote":793,"syncStatus":28,"languages":3837,"translateLanguages":3838,"viewCount":36,"primaryUrl":3839,"fullTextUrl":26,"authors":3840,"publicationType":877,"publisherRelationship":3879,"citationCount":3911,"citationInfo":3912,"publishDate":3914,"publishYear":916,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":3915,"isForceReanalyzing":1210},"a1553cd1-bcf9-4633-a553-024b448cb3d1","2024-11-27T14:14:08.497+00:00","2025-02-22T15:15:47.407+00:00",[],"Effects-of-Medium-Supplements-on-Proliferation-Differentiation-Potential-and-In-Vitro-Expansion-of-Mesenchymal-Stem-Cells",{"mag":3820,"keywords":3822,"pmc":3823,"openalex":3825,"abstract":3827,"title":3830,"pm":3833,"doi":3835},{"VOID":3821},"2063048290",{"VI":777},{"VOID":3824},"3659663",{"VOID":3826},"W2063048290",{"EN":3828,"VI":3829},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Mesenchymal stem cells (MSCs) possess great potential for use in regenerative medicine. However, their clinical application may be limited by the ability to expand their cell numbers in vitro while maintaining their differential potentials and stem cell properties. Thus the aim of this study was to test the effect of a range of medium supplements on MSC self-renewal and differentiation potential. Cells were cultured until confluent and subcultured continuously until reaching senescence. Medium supplementation with fibroblast growth factor (FGF)-2, platelet-derived growth factor (PDGF)-BB, ascorbic acid (AA), and epidermal growth factor (EGF) both increased proliferation rate and markedly increased number of cell doublings before reaching senescence, with a greater than 1,000-fold increase in total cell numbers for AA, FGF-2, and PDGF-BB compared with control cultures. Long-term culture was associated with loss of osteogenic\u002Fadipocytic differentiation potential, particularly with FGF-2 supplementation but also with AA, EGF, and PDGF-BB. In addition FGF-2 resulted in reduction in expression of CD146 and alkaline phosphatase, but this was partially reversible on removal of the supplement. Cells expressed surface markers including CD146, CD105, CD44, CD90, and CD71 by flow cytometry throughout, and expression of these putative stem cell markers persisted even after loss of differentiation potentials. Overall, medium supplementation with FGF-2, AA, EGF, and PDGF-BB greatly enhanced the total in vitro expansion capacity of MSC cultures, although differentiation potentials were lost prior to reaching senescence. Loss of differentiation potential was not reflected by changes in stem cell surface marker expression.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n               \u003Cjats:p>Các tế bào gốc trung mô (MSCs) có tiềm năng lớn trong ứng dụng y học tái tạo. Tuy nhiên, việc ứng dụng lâm sàng của chúng có thể bị hạn chế bởi khả năng mở rộng số lượng tế bào in vitro trong khi vẫn duy trì được tiềm năng phân hóa và các đặc tính của tế bào gốc. Do đó, mục tiêu của nghiên cứu này là kiểm tra ảnh hưởng của một loạt các chất bổ sung trong môi trường nuôi cấy đến khả năng tự tái tạo và phân hóa của MSC. Các tế bào được nuôi cấy cho đến khi đạt đến mật độ tối đa và được tiếp tục cấy chuyền cho đến khi đạt đến giai đoạn lão hóa. Việc bổ sung môi trường với yếu tố tăng trưởng nguyên bào sợi (FGF)-2, yếu tố tăng trưởng nguồn gốc tiểu cầu (PDGF)-BB, axit ascorbic (AA), và yếu tố tăng trưởng biểu bì (EGF) không chỉ làm tăng tốc độ tăng sinh mà còn tăng đáng kể số lần phân chia tế bào trước khi đạt đến giai đoạn lão hóa, với sự gia tăng tổng số tế bào hơn 1.000 lần đối với AA, FGF-2, và PDGF-BB so với các văn hóa đối chứng. Nuôi cấy dài hạn liên quan đến việc mất tiềm năng phân hóa thành tế bào xương\u002Ftế bào mỡ, đặc biệt là với sự bổ sung FGF-2 nhưng cũng với AA, EGF và PDGF-BB. Ngoài ra, FGF-2 đã làm giảm biểu hiện của CD146 và phosphatase kiềm, nhưng điều này có thể phục hồi một phần khi loại bỏ chất bổ sung. Các tế bào biểu hiện các dấu hiệu bề mặt bao gồm CD146, CD105, CD44, CD90 và CD71 được xác định bằng phương pháp phân tích dòng xuyên suốt, và sự biểu hiện của các dấu hiệu tế bào gốc này vẫn tồn tại ngay cả sau khi mất tiềm năng phân hóa. Tổng thể, việc bổ sung môi trường với FGF-2, AA, EGF và PDGF-BB đã tăng cường đáng kể khả năng mở rộng tổng thể in vitro của các văn hóa MSC, mặc dù tiềm năng phân hóa bị mất trước khi đạt đến lão hóa. Mất tiềm năng phân hóa không được phản ánh bằng sự thay đổi trong biểu hiện các dấu hiệu bề mặt tế bào gốc.",{"EN":3831,"VI":3832},"Effects of Medium Supplements on Proliferation, Differentiation Potential, and In Vitro Expansion of Mesenchymal Stem Cells","Ảnh hưởng của các chế phẩm đệm tới sự tăng sinh, khả năng phân biệt và sự mở rộng in vitro của các tế bào gốc trung mô",{"VOID":3834},"23197689",{"VOID":3836},"10.5966\u002Fsctm.2010-0031",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F1\u002F11\u002F771-782\u002F6385489",[3841,3862],{"id":3842,"sortIndex":115,"researcher":26,"roles":3843,"affiliations":3844,"properties":3855},"e2a4a93f-2c30-4e48-b062-51a68875c1fd",[],[3845],{"id":3846,"sortIndex":36,"affiliation":3847,"properties":26},"db558ce6-fb4e-40bb-baed-f841c25bfe15",{"id":3848,"createTime":3849,"updateTime":3849,"relativeEntities":3850,"slug":3851,"properties":3852,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"c9a91c20-7613-48e1-a445-9b670bc46856","2024-11-27T14:14:08.510+00:00",[],"Department-of-Periodontology-Dental-Institute-Guy-s-Hospital-King-s-College-London-London-United-Kingdom",{"title":3853},{"EN":3854},"Department of Periodontology, Dental Institute, Guy's Hospital, King's College London, London, United Kingdom",{"openalex":3856,"orcid":3858,"title":3860},{"VOID":3857},"A5023406605",{"VOID":3859},"https:\u002F\u002Forcid.org\u002F0000-0001-9073-8962",{"EN":3861},"Francis J. Hughes",{"id":3863,"sortIndex":36,"researcher":26,"roles":3864,"affiliations":3865,"properties":3872},"07d683f6-e4df-41a1-9549-ad4843f992bd",[],[3866],{"id":3867,"sortIndex":36,"affiliation":3868,"properties":26},"56b3028d-a0c8-4a2a-82eb-7bf416d7556b",{"id":3848,"createTime":3849,"updateTime":3849,"relativeEntities":3869,"slug":3851,"properties":3870,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3871},{"EN":3854},{"openalex":3873,"orcid":3875,"title":3877},{"VOID":3874},"A5083851949",{"VOID":3876},"https:\u002F\u002Forcid.org\u002F0009-0002-9379-3929",{"EN":3878},"Borzo Gharibi",{"url":26,"publisher":3880,"properties":3905},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3881,"slug":663,"properties":3882,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3888,"manageAffiliations":3889,"indexDatabases":3890,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":3883,"issn":3884,"introduce":3885,"eissn":3886,"title":3887},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[3891,3898],{"id":742,"indexDatabase":3892,"url":755,"indexYears":756,"academicFieldIds":3897,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":3893,"label":3894,"description":3895,"key":752,"publicationTags":3896,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":3899,"url":738,"indexYears":26,"academicFieldIds":3904,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":3900,"label":3901,"description":3902,"key":734,"publicationTags":3903,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":3906,"pages":3907,"issue":3909},{"VOID":906},{"VOID":3908},"771-782",{"VOID":3910},"11",190,{"total":3911,"publishYear":26,"statisticByYear":3913},{"2013":103,"2014":241,"2015":116,"2016":124,"2017":53,"2018":103,"2019":234,"2020":222,"2021":234,"2022":336,"2023":51,"2024":158},"2012-11-01",[3916,3918,3922,3926,3929,3933,3937,3939,3942,3946,3950,3952,3956,3960,3964,3968,3972,3976,3980,3984,3988,3992,3996,4000,4004,4008,4012,4016,4020,4024,4028,4032,4036,4040,4044,4046,4049],{"id":26,"text":2394,"url":26,"identifiers":3917},{"doi":2396},{"id":26,"text":3919,"url":26,"identifiers":3920},"Horwitz, 2002, Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone, Proc Natl Acad Sci USA, 99, 8932, 10.1073\u002Fpnas.132252399",{"doi":3921},"10.1073\u002Fpnas.132252399",{"id":26,"text":3923,"url":26,"identifiers":3924},"Quarto, 2001, Repair of large bone defects with the use of autologous bone marrow stromal cells, N Engl J Med, 344, 385, 10.1056\u002FNEJM200102013440516",{"doi":3925},"10.1056\u002FNEJM200102013440516",{"id":26,"text":3927,"url":26,"identifiers":3928},"Hernigou, 2005, Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells, J Bone Joint Surg Am, 87, 1430",{},{"id":26,"text":3930,"url":26,"identifiers":3931},"Lee, 2010, Successful reconstruction of 15-cm segmental defects by bone marrow stem cells and resected autogenous bone graft in central hemangioma, J Oral Maxillofac Surg, 68, 188, 10.1016\u002Fj.joms.2009.08.031",{"doi":3932},"10.1016\u002Fj.joms.2009.08.031",{"id":26,"text":3934,"url":26,"identifiers":3935},"Mesimäki, 2009, Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells, Int J Oral Maxillofac Surg, 38, 201, 10.1016\u002Fj.ijom.2009.01.001",{"doi":3936},"10.1016\u002Fj.ijom.2009.01.001",{"id":26,"text":2471,"url":26,"identifiers":3938},{"doi":2473},{"id":26,"text":3940,"url":26,"identifiers":3941},"Behre, 2009, Reply to “The correlation between cotransplantation of mesenchymal stem cells, higher recurrence rates in hematologic malignancy patients: Outcome of a pilot clinical study” by Ning et al, Leukemia, 178, 21579",{},{"id":26,"text":3943,"url":26,"identifiers":3944},"Timmers, 2011, Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction, Stem Cell Res, 6, 206, 10.1016\u002Fj.scr.2011.01.001",{"doi":3945},"10.1016\u002Fj.scr.2011.01.001",{"id":26,"text":3947,"url":26,"identifiers":3948},"Amado, 2005, Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction, Proc Natl Acad Sci USA, 102, 11474, 10.1073\u002Fpnas.0504388102",{"doi":3949},"10.1073\u002Fpnas.0504388102",{"id":26,"text":3755,"url":26,"identifiers":3951},{"doi":3757},{"id":26,"text":3953,"url":26,"identifiers":3954},"Tfilin, 2010, Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior, Mol Psychiatry, 15, 1164, 10.1038\u002Fmp.2009.110",{"doi":3955},"10.1038\u002Fmp.2009.110",{"id":26,"text":3957,"url":26,"identifiers":3958},"Dwyer, 2010, Advances in mesenchymal stem cell-mediated gene therapy for cancer, Stem Cell Res Ther, 1, 25, 10.1186\u002Fscrt25",{"doi":3959},"10.1186\u002Fscrt25",{"id":26,"text":3961,"url":26,"identifiers":3962},"Bernardo, 2007, Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: Further insights in the search for a fetal calf serum substitute, J Cell Physiol, 211, 121, 10.1002\u002Fjcp.20911",{"doi":3963},"10.1002\u002Fjcp.20911",{"id":26,"text":3965,"url":26,"identifiers":3966},"Sotiropoulou, 2006, Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells, Stem Cells, 24, 462, 10.1634\u002Fstemcells.2004-0331",{"doi":3967},"10.1634\u002Fstemcells.2004-0331",{"id":26,"text":3969,"url":26,"identifiers":3970},"Both, 2007, A rapid and efficient method for expansion of human mesenchymal stem cells, Tissue Eng, 13, 3, 10.1089\u002Ften.2005.0513",{"doi":3971},"10.1089\u002Ften.2005.0513",{"id":26,"text":3973,"url":26,"identifiers":3974},"Tsutsumi, 2001, Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF, Biochem Biophys Res Commun, 288, 413, 10.1006\u002Fbbrc.2001.5777",{"doi":3975},"10.1006\u002Fbbrc.2001.5777",{"id":26,"text":3977,"url":26,"identifiers":3978},"Solchaga, 2005, FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells, J Cell Physiol, 203, 398, 10.1002\u002Fjcp.20238",{"doi":3979},"10.1002\u002Fjcp.20238",{"id":26,"text":3981,"url":26,"identifiers":3982},"Martin, 1997, Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow, Endocrinology, 138, 4456, 10.1210\u002Fendo.138.10.5425",{"doi":3983},"10.1210\u002Fendo.138.10.5425",{"id":26,"text":3985,"url":26,"identifiers":3986},"Bianchi, 2003, Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2, Exp Cell Res, 287, 98, 10.1016\u002FS0014-4827(03)00138-1",{"doi":3987},"10.1016\u002FS0014-4827(03)00138-1",{"id":26,"text":3989,"url":26,"identifiers":3990},"Tamama, 2006, Epidermal growth factor as a candidate for ex vivo expansion of bone marrow–derived mesenchymal stem cells, Stem Cells, 24, 686, 10.1634\u002Fstemcells.2005-0176",{"doi":3991},"10.1634\u002Fstemcells.2005-0176",{"id":26,"text":3993,"url":26,"identifiers":3994},"Pricola, 2009, Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1\u002F2-dependent mechanism, J Cell Biochem, 108, 577, 10.1002\u002Fjcb.22289",{"doi":3995},"10.1002\u002Fjcb.22289",{"id":26,"text":3997,"url":26,"identifiers":3998},"Kumar, 2010, Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells, Tissue Eng Part A, 16, 983, 10.1089\u002Ften.tea.2009.0230",{"doi":3999},"10.1089\u002Ften.tea.2009.0230",{"id":26,"text":4001,"url":26,"identifiers":4002},"Gharibi, 2011, Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes, J Bone Miner Res, 26, 2112, 10.1002\u002Fjbmr.424",{"doi":4003},"10.1002\u002Fjbmr.424",{"id":26,"text":4005,"url":26,"identifiers":4006},"Neubauer, 2004, Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells, FEBS Lett, 577, 277, 10.1016\u002Fj.febslet.2004.10.020",{"doi":4007},"10.1016\u002Fj.febslet.2004.10.020",{"id":26,"text":4009,"url":26,"identifiers":4010},"Ito, 2008, FGF-2 increases osteogenic and chondrogenic differentiation potentials of human mesenchymal stem cells by inactivation of TGF-β signaling, Cytotechnology, 56, 1, 10.1007\u002Fs10616-007-9092-1",{"doi":4011},"10.1007\u002Fs10616-007-9092-1",{"id":26,"text":4013,"url":26,"identifiers":4014},"Lai, 2011, Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levels, Stem Cells, 29, 1102, 10.1002\u002Fstem.661",{"doi":4015},"10.1002\u002Fstem.661",{"id":26,"text":4017,"url":26,"identifiers":4018},"Osathanon, 2011, Basic fibroblast growth factor inhibits mineralization but induces neuronal differentiation by human dental pulp stem cells through a FGFR and PLCγ signaling pathway, J Cell Biochem, 112, 1807, 10.1002\u002Fjcb.23097",{"doi":4019},"10.1002\u002Fjcb.23097",{"id":26,"text":4021,"url":26,"identifiers":4022},"Hayflick, 1961, The serial cultivation of human diploid cell strains, Exp Cell Res, 25, 585, 10.1016\u002F0014-4827(61)90192-6",{"doi":4023},"10.1016\u002F0014-4827(61)90192-6",{"id":26,"text":4025,"url":26,"identifiers":4026},"Bonab, 2006, Aging of mesenchymal stem cell in vitro, BMC Cell Biol, 7, 14, 10.1186\u002F1471-2121-7-14",{"doi":4027},"10.1186\u002F1471-2121-7-14",{"id":26,"text":4029,"url":26,"identifiers":4030},"Alves, 2010, A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells, J Cell Mol Med, 14, 2729, 10.1111\u002Fj.1582-4934.2009.00931.x",{"doi":4031},"10.1111\u002Fj.1582-4934.2009.00931.x",{"id":26,"text":4033,"url":26,"identifiers":4034},"Galderisi, 2009, In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes, Stem Cells Dev, 18, 1033, 10.1089\u002Fscd.2008.0324",{"doi":4035},"10.1089\u002Fscd.2008.0324",{"id":26,"text":4037,"url":26,"identifiers":4038},"Cheng, 2011, Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts, Mol Biol Rep, 38, 5161, 10.1007\u002Fs11033-010-0665-2",{"doi":4039},"10.1007\u002Fs11033-010-0665-2",{"id":26,"text":4041,"url":26,"identifiers":4042},"Chamberlain, 2007, Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing, Stem Cells, 25, 2739, 10.1634\u002Fstemcells.2007-0197",{"doi":4043},"10.1634\u002Fstemcells.2007-0197",{"id":26,"text":966,"url":26,"identifiers":4045},{"doi":968},{"id":26,"text":4047,"url":26,"identifiers":4048},"Flores-Torales, 2010, The CD271 expression could be alone for establisher phenotypic marker in bone marrow derived mesenchymal stem cells, Folia Histochem Cytobiol, 48, 682",{},{"id":26,"text":1985,"url":26,"identifiers":4050},{"doi":1987},{"id":4052,"createTime":4053,"updateTime":4054,"relativeEntities":4055,"slug":4056,"properties":4057,"entityType":792,"verifyStatus":25,"verifyTime":4053,"verifyNote":793,"syncStatus":28,"languages":4075,"translateLanguages":4076,"viewCount":36,"primaryUrl":4077,"fullTextUrl":26,"authors":4078,"publicationType":877,"publisherRelationship":4153,"citationCount":4184,"citationInfo":4185,"publishDate":4187,"publishYear":4188,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":4189,"isForceReanalyzing":1210},"c6b62dc8-011e-4079-9196-ef8747dd1fbe","2024-10-15T11:02:10.066+00:00","2025-02-22T15:16:43.893+00:00",[],"Concise-Review-Growth-Differentiation-Factor-15-in-Pathology-A-Clinical-Role-",{"mag":4058,"keywords":4060,"pmc":4061,"openalex":4063,"abstract":4065,"title":4068,"pm":4071,"doi":4073},{"VOID":4059},"1995550877",{"VI":777},{"VOID":4062},"3841089",{"VOID":4064},"W1995550877",{"EN":4066,"VI":4067},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth factor β family discovered in a broad range of cells, as indicated by the diversity of its nomenclature. However, the only tissue that expresses a high amount of GDF15 in the physiologic state is placenta. GDF15 is easily detected in blood, and its concentration varies with age. In fact, increased blood concentration of GDF15 is associated with numerous pathological conditions. However, the biological significance underlying these observations is far from clear. GDF15 could have a positive or negative role depending on the state of cells or their environment. Furthermore, study of its biology is hampered by lack of knowledge of its receptor and thus the signaling pathways that drive its action. GDF15 seems to be an integrative signal in pathologic conditions, giving information on severity of disease. Its effectiveness in classifying patients to modulate treatment remains to be shown. Development of therapeutic interventions with GDF15 or anti-GDF15 agents remains difficult until we uncover the mechanism that drives its activity.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n               \u003Cjats:p>Yếu tố phân hóa tăng trưởng 15 (GDF15) là một thành viên khác biệt của họ yếu tố tăng trưởng biến đổi β, được phát hiện trong nhiều loại tế bào, như được chỉ ra bởi sự đa dạng trong việc đặt tên của nó. Tuy nhiên, mô duy nhất thể hiện một lượng lớn GDF15 trong trạng thái sinh lý là nhau thai. GDF15 dễ dàng được phát hiện trong máu, và nồng độ của nó thay đổi theo độ tuổi. Trên thực tế, nồng độ GDF15 trong máu tăng cao liên quan đến nhiều tình trạng bệnh lý. Tuy nhiên, ý nghĩa sinh học cơ sở cho những quan sát này vẫn chưa rõ ràng. GDF15 có thể đóng vai trò tích cực hoặc tiêu cực tùy thuộc vào trạng thái của tế bào hoặc môi trường của chúng. Hơn nữa, việc nghiên cứu sinh học của nó gặp khó khăn do thiếu kiến thức về thụ thể và do đó các con đường tín hiệu điều khiển hoạt động của nó. GDF15 dường như là một tín hiệu tích hợp trong các tình trạng bệnh lý, cung cấp thông tin về mức độ nghiêm trọng của bệnh. Hiệu quả của nó trong việc phân loại bệnh nhân để điều chỉnh điều trị vẫn cần được chứng minh. Việc phát triển các can thiệp trị liệu với GDF15 hoặc các tác nhân chống GDF15 vẫn gặp nhiều khó khăn cho đến khi chúng ta khám phá được cơ chế điều khiển hoạt động của nó.\u003C\u002Fjats:p>",{"EN":4069,"VI":4070},"Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?","Đánh Giá Ngắn Gọn: Yếu Tố Phân Hóa Tăng Trưởng 15 Trong Bệnh Lý: Vai Trò Lâm Sàng?",{"VOID":4072},"24191265",{"VOID":4074},"10.5966\u002Fsctm.2013-0055",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F2\u002F12\u002F946-952\u002F6395248",[4079,4099,4121],{"id":4080,"sortIndex":115,"researcher":26,"roles":4081,"affiliations":4082,"properties":4094},"f7bebb46-dca3-4351-afeb-c815cbd7f029",[],[4083],{"id":4084,"sortIndex":36,"affiliation":4085,"properties":26},"fee0e966-f477-4fd5-9357-52f064ac1f7c",{"id":4086,"createTime":4087,"updateTime":4088,"relativeEntities":4089,"slug":4090,"properties":4091,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"c5655e76-ff85-4796-979b-490eb8356ee4","2023-12-07T21:51:47.848+00:00","2024-10-15T11:02:10.164+00:00",[],"Hematology-Department-University-Hospital-Purpan-Toulouse-France-",{"title":4092},{"VI":4093},"Hematology Department, University Hospital Purpan, Toulouse, France;",{"openalex":4095,"title":4097},{"VOID":4096},"A5086247085",{"EN":4098},"Benjamin Hébraud",{"id":4100,"sortIndex":114,"researcher":26,"roles":4101,"affiliations":4102,"properties":4114},"ae037fd9-d038-4349-9683-ceea5f93451b",[],[4103],{"id":4104,"sortIndex":36,"affiliation":4105,"properties":26},"ace69678-4eda-438b-be35-03a5f19fefa2",{"id":4106,"createTime":4107,"updateTime":4108,"relativeEntities":4109,"slug":4110,"properties":4111,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d265460c-5346-45b6-96a6-22fd9fdc76d9","2023-12-07T04:16:44.861+00:00","2024-10-15T11:02:10.201+00:00",[],"CSA21-Toulouse-France",{"title":4112},{"VI":4113},"CSA21, Toulouse, France",{"openalex":4115,"orcid":4117,"title":4119},{"VOID":4116},"A5053209026",{"VOID":4118},"https:\u002F\u002Forcid.org\u002F0000-0002-9652-4380",{"EN":4120},"Philippe Bourin",{"id":4122,"sortIndex":36,"researcher":26,"roles":4123,"affiliations":4124,"properties":4146},"8857ac69-519d-47b7-b424-dd550eec1a8e",[],[4125,4135],{"id":4126,"sortIndex":115,"affiliation":4127,"properties":26},"8066388d-b21c-4b20-80ae-9e0eaa34f5b9",{"id":4128,"createTime":4129,"updateTime":4129,"relativeEntities":4130,"slug":4131,"properties":4132,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2b4381db-d0a4-4d03-aaf2-86ac406b62a4","2024-10-15T11:02:10.124+00:00",[],"Institut-National-de-la-Sant%C3%A9-et-de-la-Recherche-M%C3%A9dicale-INSERM-U1037-Toulouse-France",{"title":4133},{"EN":4134},"Institut National de la Santé et de la Recherche Médicale (INSERM), U1037, Toulouse, France",{"id":4136,"sortIndex":36,"affiliation":4137,"properties":26},"d0c08386-139d-498f-8295-8958210ce61b",{"id":4138,"createTime":4139,"updateTime":4140,"relativeEntities":4141,"slug":4142,"properties":4143,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"9bdf359f-3575-4014-8d7e-2a9952712a4a","2024-02-10T15:04:48.130+00:00","2024-10-15T11:02:10.120+00:00",[],"Hematology-Laboratory-University-Hospital-Purpan-Toulouse-France",{"title":4144},{"VI":4145},"Hematology Laboratory, University Hospital Purpan, Toulouse, France",{"openalex":4147,"orcid":4149,"title":4151},{"VOID":4148},"A5030565933",{"VOID":4150},"https:\u002F\u002Forcid.org\u002F0000-0003-1580-6106",{"EN":4152},"Jill Corre",{"url":26,"publisher":4154,"properties":4179},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":4155,"slug":663,"properties":4156,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":4162,"manageAffiliations":4163,"indexDatabases":4164,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":4157,"issn":4158,"introduce":4159,"eissn":4160,"title":4161},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[4165,4172],{"id":742,"indexDatabase":4166,"url":755,"indexYears":756,"academicFieldIds":4171,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":4167,"label":4168,"description":4169,"key":752,"publicationTags":4170,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":4173,"url":738,"indexYears":26,"academicFieldIds":4178,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":4174,"label":4175,"description":4176,"key":734,"publicationTags":4177,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":4180,"pages":4181,"issue":4183},{"VOID":910},{"VOID":4182},"946-952",{"VOID":1958},172,{"total":4184,"publishYear":26,"statisticByYear":4186},{"2014":115,"2015":116,"2016":53,"2017":124,"2018":298,"2019":234,"2020":222,"2021":244,"2022":336,"2023":242,"2024":50},"2013-12-01",2013,[4190,4194,4197,4201,4205,4209,4213,4217,4220,4224,4228,4232,4236,4240,4243,4246,4250,4254,4258,4262,4266,4269,4273,4277,4281,4285,4289,4293,4297,4301,4305,4309,4313,4317,4321,4325,4329,4332,4336,4340,4344,4348,4351,4355,4359,4363,4367,4371,4375,4379,4383,4387,4391,4395,4399,4403,4407,4411,4415,4419,4423,4427,4431,4435,4439,4443,4447,4451,4455,4459,4463,4467],{"id":26,"text":4191,"url":26,"identifiers":4192},"Bootcov, 1997, MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily, Proc Natl Acad Sci USA, 94, 11514, 10.1073\u002Fpnas.94.21.11514",{"doi":4193},"10.1073\u002Fpnas.94.21.11514",{"id":26,"text":4195,"url":26,"identifiers":4196},"Eling, 2006, NSAID activated gene (NAG-1), a modulator of tumorigenesis, J Biochem Mol Biol, 39, 649",{},{"id":26,"text":4198,"url":26,"identifiers":4199},"Bauskin, 2005, The propeptide mediates formation of stromal stores of PROMIC-1: Role in determining prostate cancer outcome, Cancer Res, 65, 2330, 10.1158\u002F0008-5472.CAN-04-3827",{"doi":4200},"10.1158\u002F0008-5472.CAN-04-3827",{"id":26,"text":4202,"url":26,"identifiers":4203},"Fairlie, 2000, Expression of a TGF-beta superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris, Gene, 254, 67, 10.1016\u002FS0378-1119(00)00295-X",{"doi":4204},"10.1016\u002FS0378-1119(00)00295-X",{"id":26,"text":4206,"url":26,"identifiers":4207},"Breit, 2011, The TGF-β superfamily cytokine, MIC-1\u002FGDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism, Growth Factors, 29, 187, 10.3109\u002F08977194.2011.607137",{"doi":4208},"10.3109\u002F08977194.2011.607137",{"id":26,"text":4210,"url":26,"identifiers":4211},"Hromas, 1997, PLAB, a novel placental bone morphogenetic protein, Biochim Biophys Acta, 1354, 40, 10.1016\u002FS0167-4781(97)00122-X",{"doi":4212},"10.1016\u002FS0167-4781(97)00122-X",{"id":26,"text":4214,"url":26,"identifiers":4215},"Soucek, 2010, Growth\u002Fdifferentiation factor-15 is an abundant cytokine in human seminal plasma, Hum Reprod, 25, 2962, 10.1093\u002Fhumrep\u002Fdeq264",{"doi":4216},"10.1093\u002Fhumrep\u002Fdeq264",{"id":26,"text":4218,"url":26,"identifiers":4219},"Moore, 2000, The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women, J Clin Endocrinol Metab, 85, 4781",{},{"id":26,"text":4221,"url":26,"identifiers":4222},"Tong, 2004, Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage, Lancet, 363, 129, 10.1016\u002FS0140-6736(03)15265-8",{"doi":4223},"10.1016\u002FS0140-6736(03)15265-8",{"id":26,"text":4225,"url":26,"identifiers":4226},"Wiklund, 2010, Macrophage inhibitory cytokine-1 (MIC-1\u002FGDF15): A new marker of all-cause mortality, Aging Cell, 9, 1057, 10.1111\u002Fj.1474-9726.2010.00629.x",{"doi":4227},"10.1111\u002Fj.1474-9726.2010.00629.x",{"id":26,"text":4229,"url":26,"identifiers":4230},"Daniels, 2011, Growth-differentiation factor-15 is a robust, independent predictor of 11-year mortality risk in community-dwelling older adults: The Rancho Bernardo Study, Circulation, 123, 2101, 10.1161\u002FCIRCULATIONAHA.110.979740",{"doi":4231},"10.1161\u002FCIRCULATIONAHA.110.979740",{"id":26,"text":4233,"url":26,"identifiers":4234},"Basil, 2006, Common cancer biomarkers, Cancer Res, 66, 2953, 10.1158\u002F0008-5472.CAN-05-3433",{"doi":4235},"10.1158\u002F0008-5472.CAN-05-3433",{"id":26,"text":4237,"url":26,"identifiers":4238},"Mimeault, 2010, Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer, J Cell Physiol, 224, 626, 10.1002\u002Fjcp.22196",{"doi":4239},"10.1002\u002Fjcp.22196",{"id":26,"text":4241,"url":26,"identifiers":4242},"Welsh, 2001, Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer, Cancer Res, 61, 5974",{},{"id":26,"text":4244,"url":26,"identifiers":4245},"Buckhaults, 2001, Secreted and cell surface genes expressed in benign and malignant colorectal tumors, Cancer Res, 61, 6996",{},{"id":26,"text":4247,"url":26,"identifiers":4248},"Koopmann, 2004, Serum diagnosis of pancreatic adenocarcinoma using surface-enhanced laser desorption and ionization mass spectrometry, Clin Cancer Res, 10, 860, 10.1158\u002F1078-0432.CCR-1167-3",{"doi":4249},"10.1158\u002F1078-0432.CCR-1167-3",{"id":26,"text":4251,"url":26,"identifiers":4252},"Zhang, 2009, Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma, Oral Oncol, 45, 627, 10.1016\u002Fj.oraloncology.2008.07.017",{"doi":4253},"10.1016\u002Fj.oraloncology.2008.07.017",{"id":26,"text":4255,"url":26,"identifiers":4256},"Boyle, 2009, Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity, J Invest Dermatol, 129, 383, 10.1038\u002Fjid.2008.270",{"doi":4257},"10.1038\u002Fjid.2008.270",{"id":26,"text":4259,"url":26,"identifiers":4260},"Park, 2010, Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells, BMB Rep, 43, 91, 10.5483\u002FBMBRep.2010.43.2.091",{"doi":4261},"10.5483\u002FBMBRep.2010.43.2.091",{"id":26,"text":4263,"url":26,"identifiers":4264},"Roth, 2010, GDF-15 contributes to proliferation and immune escape of malignant gliomas, Clin Cancer Res, 16, 3851, 10.1158\u002F1078-0432.CCR-10-0705",{"doi":4265},"10.1158\u002F1078-0432.CCR-10-0705",{"id":26,"text":4267,"url":26,"identifiers":4268},"Lee, 2003, Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system, Cancer Res, 63, 4648",{},{"id":26,"text":4270,"url":26,"identifiers":4271},"Corre, 2007, Bone marrow mesenchymal stem cells are abnormal in multiple myeloma, Leukemia, 21, 1079, 10.1038\u002Fsj.leu.2404621",{"doi":4272},"10.1038\u002Fsj.leu.2404621",{"id":26,"text":4274,"url":26,"identifiers":4275},"Li, 2000, Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression, J Biol Chem, 275, 20127, 10.1074\u002Fjbc.M909580199",{"doi":4276},"10.1074\u002Fjbc.M909580199",{"id":26,"text":4278,"url":26,"identifiers":4279},"Baek, 2006, Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia, Gastroenterology, 131, 1553, 10.1053\u002Fj.gastro.2006.09.015",{"doi":4280},"10.1053\u002Fj.gastro.2006.09.015",{"id":26,"text":4282,"url":26,"identifiers":4283},"Baek, 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53, Carcinogenesis, 23, 425, 10.1093\u002Fcarcin\u002F23.3.425",{"doi":4284},"10.1093\u002Fcarcin\u002F23.3.425",{"id":26,"text":4286,"url":26,"identifiers":4287},"Baek, 2005, Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein, Mol Pharmacol, 67, 356, 10.1124\u002Fmol.104.005108",{"doi":4288},"10.1124\u002Fmol.104.005108",{"id":26,"text":4290,"url":26,"identifiers":4291},"Yamaguchi, 2004, Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase\u002FAKT\u002FGSK-3beta pathway, J Biol Chem, 279, 49617, 10.1074\u002Fjbc.M408796200",{"doi":4292},"10.1074\u002Fjbc.M408796200",{"id":26,"text":4294,"url":26,"identifiers":4295},"Corre, 2012, Bioactivity and prognostic significance of growth differentiation factor GDF15 secreted by bone marrow mesenchymal stem cells in multiple myeloma, Cancer Res, 72, 1395, 10.1158\u002F0008-5472.CAN-11-0188",{"doi":4296},"10.1158\u002F0008-5472.CAN-11-0188",{"id":26,"text":4298,"url":26,"identifiers":4299},"Huang, 2007, Molecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy: Identification of a cytoprotective mechanism involving growth differentiation factor 15, Clin Cancer Res, 13, 5825, 10.1158\u002F1078-0432.CCR-07-1037",{"doi":4300},"10.1158\u002F1078-0432.CCR-07-1037",{"id":26,"text":4302,"url":26,"identifiers":4303},"Subramaniam, 2003, Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways, J Biol Chem, 278, 8904, 10.1074\u002Fjbc.M210037200",{"doi":4304},"10.1074\u002Fjbc.M210037200",{"id":26,"text":4306,"url":26,"identifiers":4307},"Johnen, 2007, Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1, Nat Med, 13, 1333, 10.1038\u002Fnm1677",{"doi":4308},"10.1038\u002Fnm1677",{"id":26,"text":4310,"url":26,"identifiers":4311},"Kim, 2008, Macrophage inhibitory cytokine-1 activates AKT and ERK-1\u002F2 via the transactivation of ErbB2 in human breast and gastric cancer cells, Carcinogenesis, 29, 704, 10.1093\u002Fcarcin\u002Fbgn031",{"doi":4312},"10.1093\u002Fcarcin\u002Fbgn031",{"id":26,"text":4314,"url":26,"identifiers":4315},"Xu, 2006, GDF15\u002FMIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation, Circ Res, 98, 342, 10.1161\u002F01.RES.0000202804.84885.d0",{"doi":4316},"10.1161\u002F01.RES.0000202804.84885.d0",{"id":26,"text":4318,"url":26,"identifiers":4319},"de Jager, 2011, Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis, J Exp Med, 208, 217, 10.1084\u002Fjem.20100370",{"doi":4320},"10.1084\u002Fjem.20100370",{"id":26,"text":4322,"url":26,"identifiers":4323},"Huh, 2010, Macrophage inhibitory cytokine-1 regulates melanoma vascular development, Am J Pathol, 176, 2948, 10.2353\u002Fajpath.2010.090963",{"doi":4324},"10.2353\u002Fajpath.2010.090963",{"id":26,"text":4326,"url":26,"identifiers":4327},"Albertoni, 2002, Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1, Oncogene, 21, 4212, 10.1038\u002Fsj.onc.1205610",{"doi":4328},"10.1038\u002Fsj.onc.1205610",{"id":26,"text":4330,"url":26,"identifiers":4331},"Liu, 2003, Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells, Cancer Res, 63, 5034",{},{"id":26,"text":4333,"url":26,"identifiers":4334},"Senapati, 2010, Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway, Oncogene, 29, 1293, 10.1038\u002Fonc.2009.420",{"doi":4335},"10.1038\u002Fonc.2009.420",{"id":26,"text":4337,"url":26,"identifiers":4338},"Wakchoure, 2009, Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss, Prostate, 69, 652, 10.1002\u002Fpros.20913",{"doi":4339},"10.1002\u002Fpros.20913",{"id":26,"text":4341,"url":26,"identifiers":4342},"Hinoi, 2012, Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia, J Bone Miner Res, 27, 938, 10.1002\u002Fjbmr.1538",{"doi":4343},"10.1002\u002Fjbmr.1538",{"id":26,"text":4345,"url":26,"identifiers":4346},"Martin, 2011, The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma, Leukemia, 25, 1533, 10.1038\u002Fleu.2011.122",{"doi":4347},"10.1038\u002Fleu.2011.122",{"id":26,"text":4349,"url":26,"identifiers":4350},"Brown, 2003, MIC-1 serum level and genotype: Associations with progress and prognosis of colorectal carcinoma, Clin Cancer Res, 9, 2642",{},{"id":26,"text":4352,"url":26,"identifiers":4353},"Ding, 2009, Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes, Endocrinology, 150, 1688, 10.1210\u002Fen.2008-0952",{"doi":4354},"10.1210\u002Fen.2008-0952",{"id":26,"text":4356,"url":26,"identifiers":4357},"Brown, 2009, Macrophage inhibitory cytokine 1: A new prognostic marker in prostate cancer, Clin Cancer Res, 15, 6658, 10.1158\u002F1078-0432.CCR-08-3126",{"doi":4358},"10.1158\u002F1078-0432.CCR-08-3126",{"id":26,"text":4360,"url":26,"identifiers":4361},"Koopmann, 2006, Serum markers in patients with resectable pancreatic adenocarcinoma: Macrophage inhibitory cytokine 1 versus CA19–9, Clin Cancer Res, 12, 442, 10.1158\u002F1078-0432.CCR-05-0564",{"doi":4362},"10.1158\u002F1078-0432.CCR-05-0564",{"id":26,"text":4364,"url":26,"identifiers":4365},"Staff, 2010, Growth differentiation factor-15 as a prognostic biomarker in ovarian cancer, Gynecol Oncol, 118, 237, 10.1016\u002Fj.ygyno.2010.05.032",{"doi":4366},"10.1016\u002Fj.ygyno.2010.05.032",{"id":26,"text":4368,"url":26,"identifiers":4369},"Staff, 2011, Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer, Clin Cancer Res, 17, 4825, 10.1158\u002F1078-0432.CCR-11-0715",{"doi":4370},"10.1158\u002F1078-0432.CCR-11-0715",{"id":26,"text":4372,"url":26,"identifiers":4373},"Kluger, 2011, Plasma markers for identifying patients with metastatic melanoma, Clin Cancer Res, 17, 2417, 10.1158\u002F1078-0432.CCR-10-2402",{"doi":4374},"10.1158\u002F1078-0432.CCR-10-2402",{"id":26,"text":4376,"url":26,"identifiers":4377},"Tanno, 2007, High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin, Nat Med, 13, 1096, 10.1038\u002Fnm1629",{"doi":4378},"10.1038\u002Fnm1629",{"id":26,"text":4380,"url":26,"identifiers":4381},"Tamary, 2008, Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I, Blood, 112, 5241, 10.1182\u002Fblood-2008-06-165738",{"doi":4382},"10.1182\u002Fblood-2008-06-165738",{"id":26,"text":4384,"url":26,"identifiers":4385},"Ramirez, 2009, Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts, Br J Haematol, 144, 251, 10.1111\u002Fj.1365-2141.2008.07441.x",{"doi":4386},"10.1111\u002Fj.1365-2141.2008.07441.x",{"id":26,"text":4388,"url":26,"identifiers":4389},"Finkenstedt, 2009, Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency, Br J Haematol, 144, 789, 10.1111\u002Fj.1365-2141.2008.07535.x",{"doi":4390},"10.1111\u002Fj.1365-2141.2008.07535.x",{"id":26,"text":4392,"url":26,"identifiers":4393},"Bruns, 2012, Multiple myeloma-related deregulation of bone marrow-derived CD34+ hematopoietic stem and progenitor cells, Blood, 120, 2620, 10.1182\u002Fblood-2011-04-347484",{"doi":4394},"10.1182\u002Fblood-2011-04-347484",{"id":26,"text":4396,"url":26,"identifiers":4397},"Brown, 2002, Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: A nested case-control study, Lancet, 359, 2159, 10.1016\u002FS0140-6736(02)09093-1",{"doi":4398},"10.1016\u002FS0140-6736(02)09093-1",{"id":26,"text":4400,"url":26,"identifiers":4401},"Kempf, 2007, Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure, J Am Coll Cardiol, 50, 1054, 10.1016\u002Fj.jacc.2007.04.091",{"doi":4402},"10.1016\u002Fj.jacc.2007.04.091",{"id":26,"text":4404,"url":26,"identifiers":4405},"Kempf, 2007, Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction, Eur Heart J, 28, 2858, 10.1093\u002Feurheartj\u002Fehm465",{"doi":4406},"10.1093\u002Feurheartj\u002Fehm465",{"id":26,"text":4408,"url":26,"identifiers":4409},"Wollert, 2007, Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome, Circulation, 115, 962, 10.1161\u002FCIRCULATIONAHA.106.650846",{"doi":4410},"10.1161\u002FCIRCULATIONAHA.106.650846",{"id":26,"text":4412,"url":26,"identifiers":4413},"Lankeit, 2008, Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism, Am J Respir Crit Care Med, 177, 1018, 10.1164\u002Frccm.200712-1786OC",{"doi":4414},"10.1164\u002Frccm.200712-1786OC",{"id":26,"text":4416,"url":26,"identifiers":4417},"Nickel, 2008, Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension, Am J Respir Crit Care Med, 178, 534, 10.1164\u002Frccm.200802-235OC",{"doi":4418},"10.1164\u002Frccm.200802-235OC",{"id":26,"text":4420,"url":26,"identifiers":4421},"Foley, 2009, Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy, Eur Heart J, 30, 2749, 10.1093\u002Feurheartj\u002Fehp300",{"doi":4422},"10.1093\u002Feurheartj\u002Fehp300",{"id":26,"text":4424,"url":26,"identifiers":4425},"Norozi, 2011, Growth differentiation factor 15: An additional diagnostic tool for the risk stratification of developing heart failure in patients with operated congenital heart defects?, Am Heart J, 162, 131, 10.1016\u002Fj.ahj.2011.03.036",{"doi":4426},"10.1016\u002Fj.ahj.2011.03.036",{"id":26,"text":4428,"url":26,"identifiers":4429},"Wollert, 2012, Growth differentiation factor 15 in heart failure: An update, Curr Heart Fail Rep, 9, 337, 10.1007\u002Fs11897-012-0113-9",{"doi":4430},"10.1007\u002Fs11897-012-0113-9",{"id":26,"text":4432,"url":26,"identifiers":4433},"Johnen, 2012, Increased expression of the TGF-b superfamily cytokine MIC-1\u002FGDF15 protects ApoE(−\u002F−) mice from the development of atherosclerosis, Cardiovasc Pathol, 21, 499, 10.1016\u002Fj.carpath.2012.02.003",{"doi":4434},"10.1016\u002Fj.carpath.2012.02.003",{"id":26,"text":4436,"url":26,"identifiers":4437},"Bonaterra, 2012, Growth differentiation factor-15 deficiency inhibits atherosclerosis progression by regulating interleukin-6-dependent inflammatory response to vascular injury, J Am Heart Assoc, 1, e002550, 10.1161\u002FJAHA.112.002550",{"doi":4438},"10.1161\u002FJAHA.112.002550",{"id":26,"text":4440,"url":26,"identifiers":4441},"Kempf, 2006, The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia\u002Freperfusion injury, Circ Res, 98, 351, 10.1161\u002F01.RES.0000202805.73038.48",{"doi":4442},"10.1161\u002F01.RES.0000202805.73038.48",{"id":26,"text":4444,"url":26,"identifiers":4445},"Xu, 2011, Growth differentiation factor 15 in cardiovascular diseases: From bench to bedside, Biomarkers, 16, 466, 10.3109\u002F1354750X.2011.580006",{"doi":4446},"10.3109\u002F1354750X.2011.580006",{"id":26,"text":4448,"url":26,"identifiers":4449},"Brown, 2007, Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis. A potential marker of erosive joint destruction, Arthritis Rheum, 56, 753, 10.1002\u002Fart.22410",{"doi":4450},"10.1002\u002Fart.22410",{"id":26,"text":4452,"url":26,"identifiers":4453},"Breit, 2012, Macrophage inhibitory cytokine-1 (MIC-1\u002FGDF15) and mortality in end-stage renal disease, Nephrol Dial Transplant, 27, 70, 10.1093\u002Fndt\u002Fgfr575",{"doi":4454},"10.1093\u002Fndt\u002Fgfr575",{"id":26,"text":4456,"url":26,"identifiers":4457},"Hellemons, 2012, Growth-differentiation factor 15 predicts worsening of albuminuria in patients with type 2 diabetes, Diabetes Care, 35, 2340, 10.2337\u002Fdc12-0180",{"doi":4458},"10.2337\u002Fdc12-0180",{"id":26,"text":4460,"url":26,"identifiers":4461},"Mensching, 2012, Local substitution of GDF-15 improves axonal and sensory recovery after peripheral nerve injury, Cell Tissue Res, 350, 225, 10.1007\u002Fs00441-012-1493-6",{"doi":4462},"10.1007\u002Fs00441-012-1493-6",{"id":26,"text":4464,"url":26,"identifiers":4465},"Hsiao, 2000, Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury, Mol Cell Biol, 20, 3742, 10.1128\u002FMCB.20.10.3742-3751.2000",{"doi":4466},"10.1128\u002FMCB.20.10.3742-3751.2000",{"id":26,"text":4468,"url":26,"identifiers":4469},"Strelau, 2009, Progressive postnatal motoneuron loss in mice lacking GDF-15, J Neurosci, 29, 13640, 10.1523\u002FJNEUROSCI.1133-09.2009",{"doi":4470},"10.1523\u002FJNEUROSCI.1133-09.2009",{"id":4472,"createTime":4473,"updateTime":4474,"relativeEntities":4475,"slug":4476,"properties":4477,"entityType":792,"verifyStatus":25,"verifyTime":4473,"verifyNote":793,"syncStatus":28,"languages":4495,"translateLanguages":4496,"viewCount":36,"primaryUrl":4497,"fullTextUrl":26,"authors":4498,"publicationType":877,"publisherRelationship":4838,"citationCount":628,"citationInfo":4870,"publishDate":4872,"publishYear":4873,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":4874,"isForceReanalyzing":1210},"1a5260b9-6660-4548-8474-28f275170015","2024-10-01T09:56:12.175+00:00","2025-02-22T15:17:42.771+00:00",[],"Intranasal-delivery-of-mesenchymal-stem-cell-derived-extracellular-vesicles-exerts-immunomodulatory-and-neuroprotective-effects-in-a-3xTg-model-of-Alzheimer-s-disease",{"mag":4478,"keywords":4480,"pmc":4481,"openalex":4483,"abstract":4485,"title":4488,"pm":4491,"doi":4493},{"VOID":4479},"3029492181",{"VI":777},{"VOID":4482},"7445021",{"VOID":4484},"W3029492181",{"EN":4486,"VI":4487},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression. In this scenario, mesenchymal stem cells (MSCs) have risen considerable interest thanks to their immunomodulatory properties, which have been largely ascribed to the release of extracellular vesicles (EVs), namely exosomes and microvesicles. Indeed, the beneficial effects of MSC-EVs in regulating the inflammatory response have been reported in different AD mouse models, upon chronic intravenous or intracerebroventricular administration. In this study, we use the triple-transgenic 3xTg mice showing for the first time that the intranasal route of administration of EVs, derived from cytokine-preconditioned MSCs, was able to induce immunomodulatory and neuroprotective effects in AD. MSC-EVs reached the brain, where they dampened the activation of microglia cells and increased dendritic spine density. MSC-EVs polarized in vitro murine primary microglia toward an anti-inflammatory phenotype suggesting that the neuroprotective effects observed in transgenic mice could result from a positive modulation of the inflammatory status. The possibility to administer MSC-EVs through a noninvasive route and the demonstration of their anti-inflammatory efficacy might accelerate the chance of a translational exploitation of MSC-EVs in AD.\u003C\u002Fjats:p>\u003Cjats:sec>\u003Cjats:title\u002F>\u003Cjats:p>Significance statement In the attempt to find a possible cure for Alzheimer's disease (AD), mesenchymal stem cells (MSCs) and their derived extracellular vesicles (EVs) are being investigated for therapeutic purposes thanks to their protective and anti-inflammatory properties. The results from this study show that MSC-EVs operate in dampening inflammation (that favors and accelerates the pathogenic process in AD) and in inducing neuroprotective effects. Furthermore, they sustain the delivery of MSC-EVs through the intranasal route, being safe and low invasive, thus laying the foundation for a translational future exploitation of MSC-EVs toward therapy.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Vai trò quan trọng của tình trạng viêm thần kinh trong việc thúc đẩy và tăng cường quá trình bệnh lý trong bệnh Alzheimer (AD) đã làm gia tăng nhu cầu hướng đến các tế bào miễn dịch bẩm sinh trong não như một chiến lược điều trị tiềm năng nhằm làm chậm tiến trình của bệnh. Trong bối cảnh này, các tế bào gốc trung mô (MSCs) đã tạo ra sự quan tâm đáng kể nhờ vào các thuộc tính điều chỉnh miễn dịch của chúng, mà chủ yếu được cho là do sự giải phóng các vesicle ngoại bào (EVs), bao gồm các exosome và microvesicle. Thật vậy, những hiệu ứng có lợi của MSC-EVs trong việc điều chỉnh phản ứng viêm đã được báo cáo trong các mô hình chuột AD khác nhau sau khi tiêm truyền tĩnh mạch hoặc vào não thất kéo dài. Trong nghiên cứu này, chúng tôi sử dụng chuột 3xTg ba chuyển gen lần đầu tiên cho thấy rằng đường tiêm qua mũi cho các EVs, thu được từ MSCs đã được xử lý bằng cytokine, có khả năng tạo ra các hiệu ứng điều chỉnh miễn dịch và bảo vệ thần kinh trong AD. MSC-EVs đã đến não, nơi chúng làm giảm mức độ kích hoạt của các tế bào microglia và tăng mật độ gai dendrite. MSC-EVs đã làm phân cực các microglia chính murine in vitro về kiểu hình chống viêm, gợi ý rằng các hiệu ứng bảo vệ thần kinh quan sát được trong chuột chuyển gen có thể là kết quả của việc điều chỉnh tích cực tình trạng viêm. Khả năng tiêm MSC-EVs qua một lộ trình không xâm lấn và sự chứng minh hiệu quả chống viêm của chúng có thể tăng tốc khả năng khai thác chuyển giao của MSC-EVs trong AD.\u003C\u002Fjats:p>\u003Cjats:sec>\u003Cjats:title\u002F>\u003Cjats:p>Tuyên bố ý nghĩa Trong nỗ lực tìm kiếm một phương pháp điều trị khả thi cho bệnh Alzheimer (AD), các tế bào gốc trung mô (MSCs) và các vesicle ngoại bào (EVs) được chiết xuất từ chúng đang được nghiên cứu với mục đích điều trị nhờ vào các thuộc tính bảo vệ và chống viêm của chúng. Các kết quả từ nghiên cứu này cho thấy MSC-EVs hoạt động trong việc giảm viêm (khiến bệnh lý trong AD trở nên trầm trọng hơn và gia tăng tốc độ phát triển của bệnh) và trong việc tạo ra các hiệu ứng bảo vệ thần kinh. Hơn nữa, các mẫu cũng hỗ trợ việc giao nộp MSC-EVs qua đường mũi, là an toàn và ít xâm lấn, do đó mở ra nền tảng cho việc khai thác trong tương lai các MSC-EVs với mục đích điều trị.",{"EN":4489,"VI":4490},"Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease","Giao nộp nội bào ngoại bào của tế bào gốc trung mô mang lại hiệu ứng điều chỉnh miễn dịch và bảo vệ thần kinh trong mô hình 3xTg của bệnh Alzheimer",{"VOID":4492},"32496649",{"VOID":4494},"10.1002\u002Fsctm.19-0327",[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F9\u002F9\u002F1068\u002F6406935",[4499,4520,4535,4562,4593,4620,4641,4664,4681,4698,4715,4732,4753,4770,4787,4804,4821],{"id":4500,"sortIndex":135,"researcher":26,"roles":4501,"affiliations":4502,"properties":4513},"f2c50866-1354-4dde-86c2-c92dd982c1a3",[],[4503],{"id":4504,"sortIndex":36,"affiliation":4505,"properties":26},"16ead810-02d3-49c5-86f1-b59cbb040d5a",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4508,"slug":4509,"properties":4510,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b4d70f93-7155-4838-a9a1-17c9a5f8909b","2024-10-01T09:56:12.192+00:00",[],"1-School-of-Medicine-and-Surgery-University-of-Milano-Bicocca-Monza-Italy",{"title":4511},{"EN":4512},"1 School of Medicine and Surgery University of Milano-Bicocca, Monza, Italy",{"openalex":4514,"orcid":4516,"title":4518},{"VOID":4515},"A5055450061",{"VOID":4517},"https:\u002F\u002Forcid.org\u002F0000-0002-5876-6215",{"EN":4519},"Mario Mauri",{"id":4521,"sortIndex":36,"researcher":26,"roles":4522,"affiliations":4523,"properties":4530},"01f9c9b9-8dd0-4160-84da-247002083b2c",[],[4524],{"id":4525,"sortIndex":36,"affiliation":4526,"properties":26},"caf1f6e7-ec43-49fa-975d-2d426010f36c",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4527,"slug":4509,"properties":4528,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4529},{"EN":4512},{"openalex":4531,"title":4533},{"VOID":4532},"A5065299567",{"EN":4534},"Morris Losurdo",{"id":4536,"sortIndex":103,"researcher":26,"roles":4537,"affiliations":4538,"properties":4555},"10903534-be84-4b42-b8bc-6acd94597171",[],[4539,4545],{"id":4540,"sortIndex":36,"affiliation":4541,"properties":26},"30ea7c2c-c1eb-458d-a547-c841558da603",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4542,"slug":4509,"properties":4543,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4544},{"EN":4512},{"id":4546,"sortIndex":115,"affiliation":4547,"properties":26},"75e9dec9-c307-4606-9c9d-6070f519d169",{"id":4548,"createTime":4549,"updateTime":4549,"relativeEntities":4550,"slug":4551,"properties":4552,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"3055140d-3742-4827-bb2b-9b415649c7c1","2024-10-01T09:56:12.320+00:00",[],"6-NeuroMI-Milan-Center-for-Neuroscience-University-of-Milano-Bicocca-Milano-MI-Italy",{"title":4553},{"EN":4554},"6 NeuroMI-Milan Center for Neuroscience University of Milano-Bicocca, Milano (MI), Italy",{"openalex":4556,"orcid":4558,"title":4560},{"VOID":4557},"A5046979142",{"VOID":4559},"https:\u002F\u002Forcid.org\u002F0000-0003-2832-6961",{"EN":4561},"Alessandra Bulbarelli",{"id":4563,"sortIndex":298,"researcher":26,"roles":4564,"affiliations":4565,"properties":4586},"f3786b73-b5e3-495b-8560-20fcbd63c67e",[],[4566,4576],{"id":4567,"sortIndex":115,"affiliation":4568,"properties":26},"93cd4812-a2dd-4dcc-8002-49f9cf2898b6",{"id":4569,"createTime":4570,"updateTime":4570,"relativeEntities":4571,"slug":4572,"properties":4573,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e1fb1ad8-0ab0-42d8-91ac-cdf95136c2bb","2024-10-01T09:56:12.305+00:00",[],"7-Department-of-Biomedical-Sciences-Humanitas-University-Pieve-Emanuele-MI-Italy",{"title":4574},{"EN":4575},"7 Department of Biomedical Sciences Humanitas University, Pieve Emanuele (MI), Italy",{"id":4577,"sortIndex":36,"affiliation":4578,"properties":26},"910e2963-7095-4e8f-b210-986d8d977cf6",{"id":4579,"createTime":4580,"updateTime":4580,"relativeEntities":4581,"slug":4582,"properties":4583,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a51a703e-f1af-439e-87f4-f0206a3ad4f7","2024-10-01T09:56:12.234+00:00",[],"3-Laboratory-of-Pharmacology-and-Brain-Pathology-Neuro-Center-Humanitas-Clinical-and-Research-Center-IRCCS-Rozzano-MI-Italy",{"title":4584},{"EN":4585},"3 Laboratory of Pharmacology and Brain Pathology, Neuro Center Humanitas Clinical and Research Center—IRCCS, Rozzano (MI), Italy",{"openalex":4587,"orcid":4589,"title":4591},{"VOID":4588},"A5048757910",{"VOID":4590},"https:\u002F\u002Forcid.org\u002F0000-0002-3569-7843",{"EN":4592},"Michela Matteoli",{"id":4594,"sortIndex":59,"researcher":26,"roles":4595,"affiliations":4596,"properties":4613},"58e90a66-73e3-4fad-a06b-01f4b239c453",[],[4597,4607],{"id":4598,"sortIndex":115,"affiliation":4599,"properties":26},"21dbc0a4-a853-43f6-8b09-a4a816b97805",{"id":4600,"createTime":4601,"updateTime":4601,"relativeEntities":4602,"slug":4603,"properties":4604,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"29c97c97-d037-4045-9e14-995cd33b6463","2024-10-01T09:56:12.238+00:00",[],"4-CNR-Institute-of-Neuroscience-Milano-Italy",{"title":4605},{"EN":4606},"4 CNR, Institute of Neuroscience, Milano, Italy",{"id":4608,"sortIndex":36,"affiliation":4609,"properties":26},"a8fedac2-634e-4faa-99fe-85b62005060c",{"id":4579,"createTime":4580,"updateTime":4580,"relativeEntities":4610,"slug":4582,"properties":4611,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4612},{"EN":4585},{"openalex":4614,"orcid":4616,"title":4618},{"VOID":4615},"A5014167568",{"VOID":4617},"https:\u002F\u002Forcid.org\u002F0000-0002-5925-6946",{"EN":4619},"Chiara Elia",{"id":4621,"sortIndex":111,"researcher":26,"roles":4622,"affiliations":4623,"properties":4634},"7c3be55d-b548-423a-a3ae-f27caa616728",[],[4624],{"id":4625,"sortIndex":36,"affiliation":4626,"properties":26},"70e9209c-94ae-468d-af30-857c1e88c6ca",{"id":4627,"createTime":4628,"updateTime":4628,"relativeEntities":4629,"slug":4630,"properties":4631,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"59486ba4-d39f-462c-b84a-b926c0fb728c","2024-10-01T09:56:12.212+00:00",[],"2-Department-of-Neurosciences-Biomedicine-and-Movement-Sciences-University-of-Verona-Verona-Italy",{"title":4632},{"EN":4633},"2 Department of Neurosciences, Biomedicine and Movement Sciences University of Verona, Verona, Italy",{"openalex":4635,"orcid":4637,"title":4639},{"VOID":4636},"A5002660712",{"VOID":4638},"https:\u002F\u002Forcid.org\u002F0000-0002-5189-7546",{"EN":4640},"Francesca Massenzio",{"id":4642,"sortIndex":336,"researcher":26,"roles":4643,"affiliations":4644,"properties":4657},"4c290d6e-b3f1-4c20-880d-44ee2383dc27",[],[4645,4651],{"id":4646,"sortIndex":115,"affiliation":4647,"properties":26},"8ea278fd-9ed4-4ea9-a901-4c451bad9f62",{"id":4548,"createTime":4549,"updateTime":4549,"relativeEntities":4648,"slug":4551,"properties":4649,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4650},{"EN":4554},{"id":4652,"sortIndex":36,"affiliation":4653,"properties":26},"9128d65f-7b73-42c2-a1ef-ced9edff3814",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4654,"slug":4509,"properties":4655,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4656},{"EN":4512},{"openalex":4658,"orcid":4660,"title":4662},{"VOID":4659},"A5031711272",{"VOID":4661},"https:\u002F\u002Forcid.org\u002F0000-0002-3883-9472",{"EN":4663},"Silvia Coco",{"id":4665,"sortIndex":356,"researcher":26,"roles":4666,"affiliations":4667,"properties":4674},"4ad489c0-40e5-4a90-a427-454452279387",[],[4668],{"id":4669,"sortIndex":36,"affiliation":4670,"properties":26},"d8bd610a-81a7-4047-a318-874403b3bc4f",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4671,"slug":4509,"properties":4672,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4673},{"EN":4512},{"openalex":4675,"orcid":4677,"title":4679},{"VOID":4676},"A5026741989",{"VOID":4678},"https:\u002F\u002Forcid.org\u002F0000-0003-4557-676X",{"EN":4680},"Antonio Torsello",{"id":4682,"sortIndex":162,"researcher":26,"roles":4683,"affiliations":4684,"properties":4691},"722ee821-c622-43fb-9f09-24b4a17f2197",[],[4685],{"id":4686,"sortIndex":36,"affiliation":4687,"properties":26},"1e163438-53a4-4d02-b344-7b010af98376",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4688,"slug":4509,"properties":4689,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4690},{"EN":4512},{"openalex":4692,"orcid":4694,"title":4696},{"VOID":4693},"A5059133468",{"VOID":4695},"https:\u002F\u002Forcid.org\u002F0000-0002-4579-7397",{"EN":4697},"Elena Lonati",{"id":4699,"sortIndex":51,"researcher":26,"roles":4700,"affiliations":4701,"properties":4708},"a597c0d0-3fda-4795-8fc7-aa256dab8713",[],[4702],{"id":4703,"sortIndex":36,"affiliation":4704,"properties":26},"3bed0702-89dd-404a-9167-c2cf2174324f",{"id":4627,"createTime":4628,"updateTime":4628,"relativeEntities":4705,"slug":4630,"properties":4706,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4707},{"EN":4633},{"openalex":4709,"orcid":4711,"title":4713},{"VOID":4710},"A5069256954",{"VOID":4712},"https:\u002F\u002Forcid.org\u002F0000-0002-3709-013X",{"EN":4714},"Mario Buffelli",{"id":4716,"sortIndex":52,"researcher":26,"roles":4717,"affiliations":4718,"properties":4725},"0a48a86f-bcc3-4fae-802d-07040115e0de",[],[4719],{"id":4720,"sortIndex":36,"affiliation":4721,"properties":26},"6e6fec1e-8878-46da-af1a-4224a870a804",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4722,"slug":4509,"properties":4723,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4724},{"EN":4512},{"openalex":4726,"orcid":4728,"title":4730},{"VOID":4727},"A5076609343",{"VOID":4729},"https:\u002F\u002Forcid.org\u002F0000-0002-8247-276X",{"EN":4731},"Elena Bresciani",{"id":4733,"sortIndex":116,"researcher":26,"roles":4734,"affiliations":4735,"properties":4746},"26bbfa68-0e51-405c-96e2-65d9787babc0",[],[4736],{"id":4737,"sortIndex":36,"affiliation":4738,"properties":26},"7dbe9a74-af36-4424-889b-acb4597ab675",{"id":4739,"createTime":4740,"updateTime":4740,"relativeEntities":4741,"slug":4742,"properties":4743,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"4a7cd49c-77b2-4c4d-81e2-9c51fd2ef386","2024-10-01T09:56:12.334+00:00",[],"5-Centro-Ricerca-Tettamanti-Pediatric-Department-University-of-Milano-Bicocca-Fondazione-MBBM-Monza-Italy",{"title":4744},{"EN":4745},"5 Centro Ricerca Tettamanti, Pediatric Department University of Milano-Bicocca, Fondazione MBBM, Monza, Italy",{"openalex":4747,"orcid":4749,"title":4751},{"VOID":4748},"A5001407752",{"VOID":4750},"https:\u002F\u002Forcid.org\u002F0000-0002-2810-1263",{"EN":4752},"Erica Dander",{"id":4754,"sortIndex":114,"researcher":26,"roles":4755,"affiliations":4756,"properties":4763},"bda6913d-50e4-4763-8c31-fd7f3339abe9",[],[4757],{"id":4758,"sortIndex":36,"affiliation":4759,"properties":26},"8c80affc-7f76-41bb-a5dd-bbe06527e7f2",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4760,"slug":4509,"properties":4761,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4762},{"EN":4512},{"openalex":4764,"orcid":4766,"title":4768},{"VOID":4765},"A5102843616",{"VOID":4767},"https:\u002F\u002Forcid.org\u002F0000-0003-3537-2181",{"EN":4769},"Claudia D’Agostino",{"id":4771,"sortIndex":50,"researcher":26,"roles":4772,"affiliations":4773,"properties":4780},"2ab27fa1-72a1-4607-a86d-9a3bb08e2d2f",[],[4774],{"id":4775,"sortIndex":36,"affiliation":4776,"properties":26},"6873ea1f-5cfc-4e38-ab0c-49cd7ceddc94",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4777,"slug":4509,"properties":4778,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4779},{"EN":4512},{"openalex":4781,"orcid":4783,"title":4785},{"VOID":4782},"A5012769425",{"VOID":4784},"https:\u002F\u002Forcid.org\u002F0000-0003-0510-9083",{"EN":4786},"Laura Molteni",{"id":4788,"sortIndex":53,"researcher":26,"roles":4789,"affiliations":4790,"properties":4797},"adbe810a-a06f-4eaf-8dff-1cbc79648b6f",[],[4791],{"id":4792,"sortIndex":36,"affiliation":4793,"properties":26},"ac2273e1-22f1-4b8a-aeac-95ffa69f673f",{"id":4739,"createTime":4740,"updateTime":4740,"relativeEntities":4794,"slug":4742,"properties":4795,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4796},{"EN":4745},{"openalex":4798,"orcid":4800,"title":4802},{"VOID":4799},"A5091256512",{"VOID":4801},"https:\u002F\u002Forcid.org\u002F0000-0001-7809-7269",{"EN":4803},"Giovanna D’Amico",{"id":4805,"sortIndex":158,"researcher":26,"roles":4806,"affiliations":4807,"properties":4814},"954882ef-1807-4df7-818d-bde330d5d747",[],[4808],{"id":4809,"sortIndex":36,"affiliation":4810,"properties":26},"eb1df708-1465-4408-86b6-c72c68e29968",{"id":4506,"createTime":4507,"updateTime":4507,"relativeEntities":4811,"slug":4509,"properties":4812,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4813},{"EN":4512},{"openalex":4815,"orcid":4817,"title":4819},{"VOID":4816},"A5076976446",{"VOID":4818},"https:\u002F\u002Forcid.org\u002F0000-0002-3709-6574",{"EN":4820},"Laura Rizzi",{"id":4822,"sortIndex":115,"researcher":26,"roles":4823,"affiliations":4824,"properties":4831},"fff2accd-15da-4f48-b26e-52e6c11e3293",[],[4825],{"id":4826,"sortIndex":36,"affiliation":4827,"properties":26},"0c1b6d60-9873-4a07-bc98-c6a4762a46b4",{"id":4627,"createTime":4628,"updateTime":4628,"relativeEntities":4828,"slug":4630,"properties":4829,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4830},{"EN":4633},{"openalex":4832,"orcid":4834,"title":4836},{"VOID":4833},"A5003911356",{"VOID":4835},"https:\u002F\u002Forcid.org\u002F0000-0002-0724-3780",{"EN":4837},"Matteo Pedrazzoli",{"url":26,"publisher":4839,"properties":4864},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":4840,"slug":663,"properties":4841,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":4847,"manageAffiliations":4848,"indexDatabases":4849,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":4842,"issn":4843,"introduce":4844,"eissn":4845,"title":4846},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[4850,4857],{"id":742,"indexDatabase":4851,"url":755,"indexYears":756,"academicFieldIds":4856,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":4852,"label":4853,"description":4854,"key":752,"publicationTags":4855,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":4858,"url":738,"indexYears":26,"academicFieldIds":4863,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":4859,"label":4860,"description":4861,"key":734,"publicationTags":4862,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":4865,"pages":4867,"issue":4869},{"VOID":4866},"9",{"VOID":4868},"1068-1084",{"VOID":4866},{"total":628,"publishYear":26,"statisticByYear":4871},{"2017":115,"2020":103,"2021":168,"2022":397,"2023":252,"2024":244},"2020-09-01",2020,[4875,4879,4883,4887,4891,4895,4899,4903,4907,4911,4915,4919,4923,4927,4931,4935,4939,4943,4947,4951,4955,4959,4962,4965,4968,4972,4976,4980,4984,4988,4992,4996,5000,5004,5008,5012,5016,5020,5024,5028,5032,5036,5040,5044,5046,5050,5054,5058,5062,5066,5070,5074,5078,5082,5086,5090,5094,5098,5102,5106,5110,5114,5118,5122,5126,5130,5134,5138,5142,5146,5150,5154,5158,5162,5166,5170,5174,5178,5182,5186,5190,5193,5197,5201,5205,5209,5213,5217,5221,5225,5229,5233,5237,5241,5245,5249,5253,5257,5261,5265,5269,5273,5277,5281,5285,5289,5293],{"id":26,"text":4876,"url":26,"identifiers":4877},"Hardy, 2002, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science, 297, 353, 10.1126\u002Fscience.1072994",{"doi":4878},"10.1126\u002Fscience.1072994",{"id":26,"text":4880,"url":26,"identifiers":4881},"Kettenmann, 2011, Physiology of microglia, Physiol Rev, 91, 461, 10.1152\u002Fphysrev.00011.2010",{"doi":4882},"10.1152\u002Fphysrev.00011.2010",{"id":26,"text":4884,"url":26,"identifiers":4885},"Limatola, 2014, Modulating neurotoxicity through CX3CL1\u002FCX3CR1 signaling, Front Cell Neurosci, 8, 1, 10.3389\u002Ffncel.2014.00229",{"doi":4886},"10.3389\u002Ffncel.2014.00229",{"id":26,"text":4888,"url":26,"identifiers":4889},"Parkhurst, 2013, Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor, Cell, 155, 1596, 10.1016\u002Fj.cell.2013.11.030",{"doi":4890},"10.1016\u002Fj.cell.2013.11.030",{"id":26,"text":4892,"url":26,"identifiers":4893},"Shechter, 2013, Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’, J Pathol, 229, 332, 10.1002\u002Fpath.4106",{"doi":4894},"10.1002\u002Fpath.4106",{"id":26,"text":4896,"url":26,"identifiers":4897},"Kigerl, 2009, Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord, J Neurosci, 29, 13435, 10.1523\u002FJNEUROSCI.3257-09.2009",{"doi":4898},"10.1523\u002FJNEUROSCI.3257-09.2009",{"id":26,"text":4900,"url":26,"identifiers":4901},"Leyns, 2017, Glial contributions to neurodegeneration in tauopathies, Mol Neurodegener, 12, 50, 10.1186\u002Fs13024-017-0192-x",{"doi":4902},"10.1186\u002Fs13024-017-0192-x",{"id":26,"text":4904,"url":26,"identifiers":4905},"Spangenberg, 2017, Inflammation in Alzheimer's disease: lessons learned from microglia-depletion models, Brain Behav Immun, 61, 1, 10.1016\u002Fj.bbi.2016.07.003",{"doi":4906},"10.1016\u002Fj.bbi.2016.07.003",{"id":26,"text":4908,"url":26,"identifiers":4909},"Czeh, 2011, The yin and yang of microglia, Dev Neurosci, 33, 199, 10.1159\u002F000328989",{"doi":4910},"10.1159\u002F000328989",{"id":26,"text":4912,"url":26,"identifiers":4913},"Heppner, 2015, Immune attack: the role of inflammation in Alzheimer disease, Nat Rev Neurosci, 16, 358, 10.1038\u002Fnrn3880",{"doi":4914},"10.1038\u002Fnrn3880",{"id":26,"text":4916,"url":26,"identifiers":4917},"Colonna, 2017, Microglia function in the central nervous system during health and neurodegeneration, Annu Rev Immunol, 35, 441, 10.1146\u002Fannurev-immunol-051116-052358",{"doi":4918},"10.1146\u002Fannurev-immunol-051116-052358",{"id":26,"text":4920,"url":26,"identifiers":4921},"Hansen, 2018, Microglia in Alzheimer's disease, J Cell Biol, 217, 459, 10.1083\u002Fjcb.201709069",{"doi":4922},"10.1083\u002Fjcb.201709069",{"id":26,"text":4924,"url":26,"identifiers":4925},"Hammond, 2019, Immune signaling in neurodegeneration, Immunity, 50, 955, 10.1016\u002Fj.immuni.2019.03.016",{"doi":4926},"10.1016\u002Fj.immuni.2019.03.016",{"id":26,"text":4928,"url":26,"identifiers":4929},"Zhang, 2006, Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice, J Neurosci Res, 84, 587, 10.1002\u002Fjnr.20962",{"doi":4930},"10.1002\u002Fjnr.20962",{"id":26,"text":4932,"url":26,"identifiers":4933},"Lee, 2010, The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease, Neurosci Lett, 481, 30, 10.1016\u002Fj.neulet.2010.06.045",{"doi":4934},"10.1016\u002Fj.neulet.2010.06.045",{"id":26,"text":4936,"url":26,"identifiers":4937},"Cova, 2010, Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease, Brain Res, 1311, 12, 10.1016\u002Fj.brainres.2009.11.041",{"doi":4938},"10.1016\u002Fj.brainres.2009.11.041",{"id":26,"text":4940,"url":26,"identifiers":4941},"Bao, 2011, Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats, Brain Res, 1367, 103, 10.1016\u002Fj.brainres.2010.10.063",{"doi":4942},"10.1016\u002Fj.brainres.2010.10.063",{"id":26,"text":4944,"url":26,"identifiers":4945},"Yokokawa, 2019, Transplantation of mesenchymal stem cells improves amyloid-β pathology by modifying microglial function and suppressing oxidative stress, J Alzheimers Dis, 72, 867, 10.3233\u002FJAD-190817",{"doi":4946},"10.3233\u002FJAD-190817",{"id":26,"text":4948,"url":26,"identifiers":4949},"Liang, 2014, Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives, Cell Transplant, 23, 1045, 10.3727\u002F096368913X667709",{"doi":4950},"10.3727\u002F096368913X667709",{"id":26,"text":4952,"url":26,"identifiers":4953},"Baek, 2019, Mesenchymal stem cell-derived extracellular vesicles as therapeutics and as a drug delivery platform, Stem Cells Translational Medicine, 8, 880, 10.1002\u002Fsctm.18-0226",{"doi":4954},"10.1002\u002Fsctm.18-0226",{"id":26,"text":4956,"url":26,"identifiers":4957},"EL Andaloussi, 2013, Extracellular vesicles: biology and emerging therapeutic opportunities, Nat Rev Drug Discov, 12, 347, 10.1038\u002Fnrd3978",{"doi":4958},"10.1038\u002Fnrd3978",{"id":26,"text":4960,"url":26,"identifiers":4961},"Stahl, 2019, Extracellular vesicles: exosomes and microvesicles, integrators of homeostasis, Phys Ther, 34, 169",{},{"id":26,"text":4963,"url":26,"identifiers":4964},"Lo Sicco, 2017, Mesenchymal stem cell-derived extracellular vesicles as mediators of anti-inflammatory effects: endorsement of macrophage polarization, Stem Cells Translational Medicine, 6, 1018, 10.1002\u002Fsctm.16-0363",{"doi":2532},{"id":26,"text":4966,"url":26,"identifiers":4967},"Álvarez, 2018, The immunomodulatory activity of extracellular vesicles derived from endometrial mesenchymal stem cells on CD4+ T cells is partially mediated by TGFbeta, J Tissue Eng Regen Med, 12, 2088",{},{"id":26,"text":4969,"url":26,"identifiers":4970},"Elia, 2019, Extracellular vesicles from mesenchymal stem cells exert pleiotropic effects on amyloid-β, inflammation, and regeneration: a spark of hope for Alzheimer's disease from tiny structures?, Bioessays, 41, 10.1002\u002Fbies.201800199",{"doi":4971},"10.1002\u002Fbies.201800199",{"id":26,"text":4973,"url":26,"identifiers":4974},"Del Fattore, 2015, Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells, Expert Opin Biol Ther, 15, 495, 10.1517\u002F14712598.2015.997706",{"doi":4975},"10.1517\u002F14712598.2015.997706",{"id":26,"text":4977,"url":26,"identifiers":4978},"Cuerquis, 2014, Human mesenchymal stromal cells transiently increase cytokine production by activated T cells before suppressing T-cell proliferation: effect of interferon-γ and tumor necrosis factor-α stimulation, Cytotherapy, 16, 191, 10.1016\u002Fj.jcyt.2013.11.008",{"doi":4979},"10.1016\u002Fj.jcyt.2013.11.008",{"id":26,"text":4981,"url":26,"identifiers":4982},"Saparov, 2016, Preconditioning of human mesenchymal stem cells to enhance their regulation of the immune response, Stem Cells Int, 2016, 1, 10.1155\u002F2016\u002F3924858",{"doi":4983},"10.1155\u002F2016\u002F3924858",{"id":26,"text":4985,"url":26,"identifiers":4986},"Fatima, 2017, Non-coding RNAs in mesenchymal stem cell-derived extracellular vesicles: deciphering regulatory roles in stem cell potency, inflammatory resolve, and tissue regeneration, Front Genet, 8, 161, 10.3389\u002Ffgene.2017.00161",{"doi":4987},"10.3389\u002Ffgene.2017.00161",{"id":26,"text":4989,"url":26,"identifiers":4990},"Hu, 2018, Preconditioning influences mesenchymal stem cell properties in vitro and in vivo, J Cell Mol Med, 22, 1428, 10.1111\u002Fjcmm.13492",{"doi":4991},"10.1111\u002Fjcmm.13492",{"id":26,"text":4993,"url":26,"identifiers":4994},"Ruppert, 2018, Human mesenchymal stromal cell-derived extracellular vesicles modify microglial response and improve clinical outcomes in experimental spinal cord injury, Sci Rep, 8, 480, 10.1038\u002Fs41598-017-18867-w",{"doi":4995},"10.1038\u002Fs41598-017-18867-w",{"id":26,"text":4997,"url":26,"identifiers":4998},"Cui, 2018, Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP\u002FPS1 mice, FASEB J, 32, 654, 10.1096\u002Ffj.201700600R",{"doi":4999},"10.1096\u002Ffj.201700600R",{"id":26,"text":5001,"url":26,"identifiers":5002},"Wang, 2018, Mesenchymal stem cell-derived extracellular vesicles suppresses iNOS expression and ameliorates neural impairment in Alzheimer's disease mice, J Alzheimers Dis, 61, 1005, 10.3233\u002FJAD-170848",{"doi":5003},"10.3233\u002FJAD-170848",{"id":26,"text":5005,"url":26,"identifiers":5006},"Elia, 2019, Intracerebral injection of extracellular vesicles from mesenchymal stem cells exerts reduced Aβ plaque burden in early stages of a preclinical model of Alzheimer's disease, Cells, 8, 1059, 10.3390\u002Fcells8091059",{"doi":5007},"10.3390\u002Fcells8091059",{"id":26,"text":5009,"url":26,"identifiers":5010},"Vinci, 2017, Mesenchymal stromal cell-secreted chemerin is a novel immunomodulatory molecule driving the migration of ChemR23-expressing cells, Cytotherapy, 19, 200, 10.1016\u002Fj.jcyt.2016.11.006",{"doi":5011},"10.1016\u002Fj.jcyt.2016.11.006",{"id":26,"text":5013,"url":26,"identifiers":5014},"Théry, 2006, Isolation and characterization of exosomes from cell culture supernatants and biological fluids, Curr Protoc Cell Biol, 30, 3.22.1, 10.1002\u002F0471143030.cb0322s30",{"doi":5015},"10.1002\u002F0471143030.cb0322s30",{"id":26,"text":5017,"url":26,"identifiers":5018},"Verderio, 2012, Myeloid microvesicles are a marker and therapeutic target for neuroinflammation, Ann Neurol, 72, 610, 10.1002\u002Fana.23627",{"doi":5019},"10.1002\u002Fana.23627",{"id":26,"text":5021,"url":26,"identifiers":5022},"Li, 2013, An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research, Life Sci, 92, 747, 10.1016\u002Fj.lfs.2013.02.014",{"doi":5023},"10.1016\u002Fj.lfs.2013.02.014",{"id":26,"text":5025,"url":26,"identifiers":5026},"Moritz, 2017, Tubulin or not tubulin: heading toward total protein staining as loading control in western blots, Proteomics, 17, 10.1002\u002Fpmic.201600189",{"doi":5027},"10.1002\u002Fpmic.201600189",{"id":26,"text":5029,"url":26,"identifiers":5030},"Das, 2013, Neural Development: Methods and Protocols, 313, 10.1007\u002F978-1-62703-444-9_29",{"doi":5031},"10.1007\u002F978-1-62703-444-9_29",{"id":26,"text":5033,"url":26,"identifiers":5034},"Zaqout, 2016, Golgi-Cox staining step by step, Front Neuroanat, 10, 38, 10.3389\u002Ffnana.2016.00038",{"doi":5035},"10.3389\u002Ffnana.2016.00038",{"id":26,"text":5037,"url":26,"identifiers":5038},"Gibb, 1998, A method for vibratome sectioning of Golgi-Cox stained whole rat brain, J Neurosci Methods, 79, 1, 10.1016\u002FS0165-0270(97)00163-5",{"doi":5039},"10.1016\u002FS0165-0270(97)00163-5",{"id":26,"text":5041,"url":26,"identifiers":5042},"Pedrazzoli, 2019, Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease, Neurobiol Dis, 132, 10.1016\u002Fj.nbd.2019.104568",{"doi":5043},"10.1016\u002Fj.nbd.2019.104568",{"id":26,"text":966,"url":26,"identifiers":5045},{"doi":968},{"id":26,"text":5047,"url":26,"identifiers":5048},"Tu, 2010, Mesenchymal stem cells inhibit complement activation by secreting factor H, Stem Cells Dev, 19, 1803, 10.1089\u002Fscd.2009.0418",{"doi":5049},"10.1089\u002Fscd.2009.0418",{"id":26,"text":5051,"url":26,"identifiers":5052},"François, 2012, Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation, Mol Ther, 20, 187, 10.1038\u002Fmt.2011.189",{"doi":5053},"10.1038\u002Fmt.2011.189",{"id":26,"text":5055,"url":26,"identifiers":5056},"Kota, 2017, Prostaglandin E2 indicates therapeutic efficacy of mesenchymal stem cells in experimental traumatic brain injury, Stem Cells, 35, 1416, 10.1002\u002Fstem.2603",{"doi":5057},"10.1002\u002Fstem.2603",{"id":26,"text":5059,"url":26,"identifiers":5060},"Imai, 1996, A novel gene Iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage, Biochem Biophys Res Commun, 224, 855, 10.1006\u002Fbbrc.1996.1112",{"doi":5061},"10.1006\u002Fbbrc.1996.1112",{"id":26,"text":5063,"url":26,"identifiers":5064},"Mastrangelo, 2008, Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice, BMC Neurosci, 9, 81, 10.1186\u002F1471-2202-9-81",{"doi":5065},"10.1186\u002F1471-2202-9-81",{"id":26,"text":5067,"url":26,"identifiers":5068},"Long, 2017, Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus, Proc Natl Acad Sci USA, 114, E3536, 10.1073\u002Fpnas.1703920114",{"doi":5069},"10.1073\u002Fpnas.1703920114",{"id":26,"text":5071,"url":26,"identifiers":5072},"Perry, 2013, Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration, Semin Immunopathol, 35, 601, 10.1007\u002Fs00281-013-0382-8",{"doi":5073},"10.1007\u002Fs00281-013-0382-8",{"id":26,"text":5075,"url":26,"identifiers":5076},"Davis, 1994, Cellular forms and functions of brain microglia, Brain Res Bull, 34, 73, 10.1016\u002F0361-9230(94)90189-9",{"doi":5077},"10.1016\u002F0361-9230(94)90189-9",{"id":26,"text":5079,"url":26,"identifiers":5080},"Shi, 2017, Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\u002FPS1 mice, Sci Transl Med, 9, 10.1126\u002Fscitranslmed.aaf6295",{"doi":5081},"10.1126\u002Fscitranslmed.aaf6295",{"id":26,"text":5083,"url":26,"identifiers":5084},"Rajendran, 2018, Microglia-mediated synapse loss in Alzheimer's disease, J Neurosci, 38, 2911, 10.1523\u002FJNEUROSCI.1136-17.2017",{"doi":5085},"10.1523\u002FJNEUROSCI.1136-17.2017",{"id":26,"text":5087,"url":26,"identifiers":5088},"Koniusz, 2016, Extracellular vesicles in physiology, pathology, and therapy of the immune and central nervous system, with focus on extracellular vesicles derived from mesenchymal stem cells as therapeutic tools, Front Cell Neurosci, 10, 109, 10.3389\u002Ffncel.2016.00109",{"doi":5089},"10.3389\u002Ffncel.2016.00109",{"id":26,"text":5091,"url":26,"identifiers":5092},"Maggini, 2010, Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile, PLoS One, 5, 10.1371\u002Fjournal.pone.0009252",{"doi":5093},"10.1371\u002Fjournal.pone.0009252",{"id":26,"text":5095,"url":26,"identifiers":5096},"Griffin, 1989, Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease, Proc Natl Acad Sci USA, 86, 7611, 10.1073\u002Fpnas.86.19.7611",{"doi":5097},"10.1073\u002Fpnas.86.19.7611",{"id":26,"text":5099,"url":26,"identifiers":5100},"Licastro, 2000, Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?, J Neuroimmunol, 103, 97, 10.1016\u002FS0165-5728(99)00226-X",{"doi":5101},"10.1016\u002FS0165-5728(99)00226-X",{"id":26,"text":5103,"url":26,"identifiers":5104},"Lim, 2013, Neuronal synapse formation induced by microglia and interleukin 10, PLoS One, 8, 10.1371\u002Fjournal.pone.0081218",{"doi":5105},"10.1371\u002Fjournal.pone.0081218",{"id":26,"text":5107,"url":26,"identifiers":5108},"Jaimes, 2016, Mesenchymal stem cell-derived microvesicles modulate lipopolysaccharides-induced inflammatory responses to microglia cells, Stem Cells, 35, 812, 10.1002\u002Fstem.2541",{"doi":5109},"10.1002\u002Fstem.2541",{"id":26,"text":5111,"url":26,"identifiers":5112},"Harting, 2018, Inflammation-stimulated mesenchymal stromal cell-derived extracellular vesicles attenuate inflammation, Stem Cells, 36, 79, 10.1002\u002Fstem.2730",{"doi":5113},"10.1002\u002Fstem.2730",{"id":26,"text":5115,"url":26,"identifiers":5116},"Sasaki, 2001, Iba1 is an actin-cross-linking protein in macrophages\u002Fmicroglia, Biochem Biophys Res Commun, 286, 292, 10.1006\u002Fbbrc.2001.5388",{"doi":5117},"10.1006\u002Fbbrc.2001.5388",{"id":26,"text":5119,"url":26,"identifiers":5120},"Marzolo, 1999, Mannose receptor is present in a functional state in rat microglial cells, J Neurosci Res, 58, 387, 10.1002\u002F(SICI)1097-4547(19991101)58:3\u003C387::AID-JNR4>3.0.CO;2-L",{"doi":5121},"10.1002\u002F(SICI)1097-4547(19991101)58:3\u003C387::AID-JNR4>3.0.CO;2-L",{"id":26,"text":5123,"url":26,"identifiers":5124},"Durafourt, 2012, Comparison of polarization properties of human adult microglia and blood-derived macrophages, Glia, 60, 717, 10.1002\u002Fglia.22298",{"doi":5125},"10.1002\u002Fglia.22298",{"id":26,"text":5127,"url":26,"identifiers":5128},"Chhor, 2013, Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro, Brain Behav Immun, 32, 70, 10.1016\u002Fj.bbi.2013.02.005",{"doi":5129},"10.1016\u002Fj.bbi.2013.02.005",{"id":26,"text":5131,"url":26,"identifiers":5132},"Hammond, 2019, Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes, Immunity, 50, 253, 10.1016\u002Fj.immuni.2018.11.004",{"doi":5133},"10.1016\u002Fj.immuni.2018.11.004",{"id":26,"text":5135,"url":26,"identifiers":5136},"Matcovitch-Natan, 2016, Microglia development follows a stepwise program to regulate brain homeostasis, Science, 353, aad8670-1, 10.1126\u002Fscience.aad8670",{"doi":5137},"10.1126\u002Fscience.aad8670",{"id":26,"text":5139,"url":26,"identifiers":5140},"Prockop, 2013, Concise review: two negative feedback loops place mesenchymal stem\u002Fstromal cells at the center of early regulators of inflammation, Stem Cells, 31, 2042, 10.1002\u002Fstem.1400",{"doi":5141},"10.1002\u002Fstem.1400",{"id":26,"text":5143,"url":26,"identifiers":5144},"Kushima, 1992, Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains, Neurosci Res, 13, 267, 10.1016\u002F0168-0102(92)90039-F",{"doi":5145},"10.1016\u002F0168-0102(92)90039-F",{"id":26,"text":5147,"url":26,"identifiers":5148},"Oh, 2010, Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus, J Neurosci Res, 88, 2798, 10.1002\u002Fjnr.22447",{"doi":5149},"10.1002\u002Fjnr.22447",{"id":26,"text":5151,"url":26,"identifiers":5152},"Sato, 2012, Interleukin-1 participates in the classical and alternative activation of microglia\u002Fmacrophages after spinal cord injury, J Neuroinflammation, 9, 1, 10.1186\u002F1742-2094-9-65",{"doi":5153},"10.1186\u002F1742-2094-9-65",{"id":26,"text":5155,"url":26,"identifiers":5156},"Kowsar, 2019, Understanding the hidden relations between pro- and anti-inflammatory cytokine genes in bovine oviduct epithelium using a multilayer response surface method, Sci Rep, 9, 1, 10.1038\u002Fs41598-019-39081-w",{"doi":5157},"10.1038\u002Fs41598-019-39081-w",{"id":26,"text":5159,"url":26,"identifiers":5160},"Fitzgerald, 2018, A system of cytokines encapsulated in extracellular vesicles, Sci Rep, 8, 1, 10.1038\u002Fs41598-018-27190-x",{"doi":5161},"10.1038\u002Fs41598-018-27190-x",{"id":26,"text":5163,"url":26,"identifiers":5164},"Zilka, 2011, Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau, Neuroscience, 193, 330, 10.1016\u002Fj.neuroscience.2011.06.088",{"doi":5165},"10.1016\u002Fj.neuroscience.2011.06.088",{"id":26,"text":5167,"url":26,"identifiers":5168},"Lee, 2012, Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation, Neurobiol Aging, 33, 588, 10.1016\u002Fj.neurobiolaging.2010.03.024",{"doi":5169},"10.1016\u002Fj.neurobiolaging.2010.03.024",{"id":26,"text":5171,"url":26,"identifiers":5172},"Yun, 2013, Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ(1–42)-infused mouse model of Alzheimer's disease, Cell Death Dis, 4, 10.1038\u002Fcddis.2013.490",{"doi":5173},"10.1038\u002Fcddis.2013.490",{"id":26,"text":5175,"url":26,"identifiers":5176},"Yang, 2013, Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP\u002FPS1 transgenic mouse model, Stem Cell Res Ther, 4, 76, 10.1186\u002Fscrt227",{"doi":5177},"10.1186\u002Fscrt227",{"id":26,"text":5179,"url":26,"identifiers":5180},"Zhao, 2018, Transplantation of human menstrual blood-derived mesenchymal stem cells alleviates Alzheimer's disease-like pathology in APP\u002FPS1 transgenic mice, Front Mol Neurosci, 11, 140, 10.3389\u002Ffnmol.2018.00140",{"doi":5181},"10.3389\u002Ffnmol.2018.00140",{"id":26,"text":5183,"url":26,"identifiers":5184},"Oh, 2015, Mesenchymal stem cells increase hippocampal neurogenesis and neuronal differentiation by enhancing the Wnt signaling pathway in an Alzheimer's disease model, Cell Transplant, 24, 1097, 10.3727\u002F096368914X679237",{"doi":5185},"10.3727\u002F096368914X679237",{"id":26,"text":5187,"url":26,"identifiers":5188},"Naaldijk, 2016, Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP\u002FPS1 Alzheimer mice, Neuropathol Appl Neurobiol, 43, 299, 10.1111\u002Fnan.12319",{"doi":5189},"10.1111\u002Fnan.12319",{"id":26,"text":5191,"url":26,"identifiers":5192},"Lener, 2015, Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper, J Extracell Vesicles, 4, 30087, 10.3402\u002Fjev.v4.30087",{"doi":2516},{"id":26,"text":5194,"url":26,"identifiers":5195},"Narbute, 2019, Intranasal administration of extracellular vesicles derived from human teeth stem cells improves motor symptoms and normalizes tyrosine hydroxylase expression in the substantia nigra and striatum of the 6-hydroxydopamine-treated rats, Stem Cells Translational Medicine, 8, 490, 10.1002\u002Fsctm.18-0162",{"doi":5196},"10.1002\u002Fsctm.18-0162",{"id":26,"text":5198,"url":26,"identifiers":5199},"Kodali, 2020, Intranasally administered human MSC-derived extracellular vesicles pervasively incorporate into neurons and microglia in both intact and status epilepticus injured forebrain, Int J Mol Sci, 21, 181, 10.3390\u002Fijms21010181",{"doi":5200},"10.3390\u002Fijms21010181",{"id":26,"text":5202,"url":26,"identifiers":5203},"Zhuang, 2011, Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain, Mol Ther, 19, 1769, 10.1038\u002Fmt.2011.164",{"doi":5204},"10.1038\u002Fmt.2011.164",{"id":26,"text":5206,"url":26,"identifiers":5207},"Perets, 2018, Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice, Mol Autism, 9, 57, 10.1186\u002Fs13229-018-0240-6",{"doi":5208},"10.1186\u002Fs13229-018-0240-6",{"id":26,"text":5210,"url":26,"identifiers":5211},"Reza-Zaldivar, 2019, Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer's disease, Neural Regen Res, 14, 1626, 10.4103\u002F1673-5374.255978",{"doi":5212},"10.4103\u002F1673-5374.255978",{"id":26,"text":5214,"url":26,"identifiers":5215},"Oddo, 2003, Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction, Neuron, 39, 409, 10.1016\u002FS0896-6273(03)00434-3",{"doi":5216},"10.1016\u002FS0896-6273(03)00434-3",{"id":26,"text":5218,"url":26,"identifiers":5219},"Janelsins, 2005, Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice, J Neuroinflammation, 2, 23, 10.1186\u002F1742-2094-2-23",{"doi":5220},"10.1186\u002F1742-2094-2-23",{"id":26,"text":5222,"url":26,"identifiers":5223},"Rodríguez, 2010, Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease, Cell Death Dis, 1, 10.1038\u002Fcddis.2009.2",{"doi":5224},"10.1038\u002Fcddis.2009.2",{"id":26,"text":5226,"url":26,"identifiers":5227},"McGeer, 1987, Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR, Neurosci Lett, 79, 195, 10.1016\u002F0304-3940(87)90696-3",{"doi":5228},"10.1016\u002F0304-3940(87)90696-3",{"id":26,"text":5230,"url":26,"identifiers":5231},"Jimenez, 2008, Inflammatory response in the hippocampus of PS1M146L\u002FAPP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic, J Neurosci, 28, 11650, 10.1523\u002FJNEUROSCI.3024-08.2008",{"doi":5232},"10.1523\u002FJNEUROSCI.3024-08.2008",{"id":26,"text":5234,"url":26,"identifiers":5235},"Fyfe, 2016, Blocking microglial proliferation halts Alzheimer disease in mice, Nat Rev Neurol, 12, 64, 10.1038\u002Fnrneurol.2016.6",{"doi":5236},"10.1038\u002Fnrneurol.2016.6",{"id":26,"text":5238,"url":26,"identifiers":5239},"Olmos-Alonso, 2016, Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology, Brain, 139, 891, 10.1093\u002Fbrain\u002Fawv379",{"doi":5240},"10.1093\u002Fbrain\u002Fawv379",{"id":26,"text":5242,"url":26,"identifiers":5243},"Gate, 2010, Macrophages in Alzheimer's disease: the blood-borne identity, J Neural Transm, 117, 961, 10.1007\u002Fs00702-010-0422-7",{"doi":5244},"10.1007\u002Fs00702-010-0422-7",{"id":26,"text":5246,"url":26,"identifiers":5247},"Thériault, 2015, The dynamics of monocytes and microglia in Alzheimer's disease, Alzheimers Res Ther, 7, 1, 10.1186\u002Fs13195-015-0125-2",{"doi":5248},"10.1186\u002Fs13195-015-0125-2",{"id":26,"text":5250,"url":26,"identifiers":5251},"Henao Agudelo, 2017, Mesenchymal stromal cell-derived microvesicles regulate an internal pro-inflammatory program in activated macrophages, Front Immunol, 8, 881, 10.3389\u002Ffimmu.2017.00881",{"doi":5252},"10.3389\u002Ffimmu.2017.00881",{"id":26,"text":5254,"url":26,"identifiers":5255},"Unger, 2018, Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice, J Neuroinflammation, 15, 1, 10.1186\u002Fs12974-018-1304-4",{"doi":5256},"10.1186\u002Fs12974-018-1304-4",{"id":26,"text":5258,"url":26,"identifiers":5259},"Pellicanò, 2012, Immune profiling of Alzheimer patients, J Neuroimmunol, 242, 52, 10.1016\u002Fj.jneuroim.2011.11.005",{"doi":5260},"10.1016\u002Fj.jneuroim.2011.11.005",{"id":26,"text":5262,"url":26,"identifiers":5263},"Baruch, 2015, Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer's disease pathology, Nat Commun, 6, 7967, 10.1038\u002Fncomms8967",{"doi":5264},"10.1038\u002Fncomms8967",{"id":26,"text":5266,"url":26,"identifiers":5267},"Marsh, 2016, The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function, Proc Natl Acad Sci USA, 113, E1316, 10.1073\u002Fpnas.1525466113",{"doi":5268},"10.1073\u002Fpnas.1525466113",{"id":26,"text":5270,"url":26,"identifiers":5271},"Zanier, 2014, Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma, Neurotherapeutics, 11, 679, 10.1007\u002Fs13311-014-0277-y",{"doi":5272},"10.1007\u002Fs13311-014-0277-y",{"id":26,"text":5274,"url":26,"identifiers":5275},"Bodart-Santos, 2019, Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers, Stem Cell Res Ther, 10, 1, 10.1186\u002Fs13287-019-1432-5",{"doi":5276},"10.1186\u002Fs13287-019-1432-5",{"id":26,"text":5278,"url":26,"identifiers":5279},"Godoy, 2018, Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers, J Biol Chem, 293, 1957, 10.1074\u002Fjbc.M117.807180",{"doi":5280},"10.1074\u002Fjbc.M117.807180",{"id":26,"text":5282,"url":26,"identifiers":5283},"Ransohoff, 2010, The myeloid cells of the central nervous system parenchyma, Nature, 468, 253, 10.1038\u002Fnature09615",{"doi":5284},"10.1038\u002Fnature09615",{"id":26,"text":5286,"url":26,"identifiers":5287},"Tong, 2012, Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase, J Neurosci, 32, 17714, 10.1523\u002FJNEUROSCI.1253-12.2012",{"doi":5288},"10.1523\u002FJNEUROSCI.1253-12.2012",{"id":26,"text":5290,"url":26,"identifiers":5291},"Hong, 2016, Complement and microglia mediate early synapse loss in Alzheimer mouse models, Science, 352, 712, 10.1126\u002Fscience.aad8373",{"doi":5292},"10.1126\u002Fscience.aad8373",{"id":26,"text":5294,"url":26,"identifiers":5295},"Haney, 2015, Exosomes as drug delivery vehicles for Parkinson's disease therapy, J Control Release, 207, 18, 10.1016\u002Fj.jconrel.2015.03.033",{"doi":5296},"10.1016\u002Fj.jconrel.2015.03.033",{"id":5298,"createTime":5299,"updateTime":5300,"relativeEntities":5301,"slug":5302,"properties":5303,"entityType":792,"verifyStatus":25,"verifyTime":5299,"verifyNote":793,"syncStatus":28,"languages":5320,"translateLanguages":5321,"viewCount":36,"primaryUrl":5322,"fullTextUrl":26,"authors":5323,"publicationType":877,"publisherRelationship":5517,"citationCount":5550,"citationInfo":5551,"publishDate":5553,"publishYear":5554,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":5555,"isForceReanalyzing":1210},"22474a09-2d84-4aa3-b838-5446fbb6b40d","2024-10-01T09:54:54.179+00:00","2025-02-22T15:18:40.112+00:00",[],"Intranasal-Administration-of-Extracellular-Vesicles-Derived-from-Human-Teeth-Stem-Cells-Improves-Motor-Symptoms-and-Normalizes-Tyrosine-Hydroxylase-Expression-in-the-Substantia-Nigra-and-Striatum-of-the-6-Hydroxydopamine-Treated-Rats",{"mag":5304,"keywords":5306,"pmc":5307,"openalex":5309,"abstract":5311,"title":5314,"pm":5317,"doi":5319},{"VOID":5305},"2914375886",{"VI":777},{"VOID":5308},"6477008",{"VOID":5310},"W2914375886",{"EN":5312,"VI":5313},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:p>Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression of neurodegeneration. Extracellular vesicles (EVs) can cross the blood–brain barrier and represent promising alternative to the classical treatment strategies. In the present study, we examined therapeutic effects of intranasal administration of EVs derived from human exfoliated deciduous teeth stem cells (SHEDs) on unilateral 6-hydroxydopamine (6-OHDA) medial forebrain bundle (MFB) rat model of PD. CatWalk gait tests revealed that EVs effectively suppressed 6-OHDA-induced gait impairments. All tested gait parameters (stand, stride length, step cycle, and duty cycle) were significantly improved in EV-treated animals when compared with 6-OHDA-lesion group rats. Furthermore, EVs slowed down numbers of 6-OHDA-induced contralateral rotations in apomorphine test. Improvements in motor function correlated with normalization of tyrosine hydroxylase expression in the striatum and substantia nigra. In conclusion, we demonstrated, for the first time, the therapeutic efficacy of intranasal administration of EVs derived from SHEDs in a rat model of PD induced by 6-OHDA intra-MFB lesion. Our findings could be potentially exploited for the development of new treatment strategies against PD.\u003C\u002Fjats:p>\n               \u003Cjats:sec>\n                  \u003Cjats:title \u002F>\n               \u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n               \u003Cjats:p>Bệnh Parkinson (PD) là rối loạn thoái hóa thần kinh phổ biến thứ hai, ảnh hưởng đến hàng triệu người trên toàn thế giới. Hiện tại, không có phương pháp chữa trị hiệu quả cho PD; các phương pháp điều trị hiện có chỉ nhằm giải quyết triệu chứng mà không làm ngừng tiến triển của sự thoái hóa thần kinh. Các vesicle ngoại bào (EVs) có khả năng vượt qua hàng rào máu-não và thể hiện tiềm năng như một liệu pháp thay thế đáng hứa hẹn so với các chiến lược điều trị cổ điển. Trong nghiên cứu này, chúng tôi đã xem xét tác dụng điều trị của việc đưa EVs qua đường mũi, có nguồn gốc từ tế bào gốc từ răng sữa người (SHEDs), trên mô hình chuột mắc PD do 6-hydroxydopamine (6-OHDA) gây ra. Các thử nghiệm đi bộ CatWalk cho thấy rằng EVs đã hiệu quả trong việc làm giảm các vấn đề về đi lại do 6-OHDA gây ra. Tất cả các thông số đi bộ được thử nghiệm (thời gian đứng, độ dài bước, chu trình bước và chu trình hoạt động) đều được cải thiện đáng kể ở các động vật được điều trị bằng EVs so với nhóm chuột bị tổn thương ở 6-OHDA. Hơn nữa, EVs đã làm chậm số lần quay bên trái do 6-OHDA gây ra trong bài thử nghiệm apomorphine. Sự cải thiện trong chức năng vận động có liên quan đến sự bình thường hóa biểu hiện của tyrosine hydroxylase trong nhân đuôi và chất đen. Kết luận, chúng tôi đã chứng minh, lần đầu tiên, hiệu quả điều trị của việc đưa EVs qua đường mũi có nguồn gốc từ SHEDs trong mô hình chuột mắc PD do tổn thương intra-MFB bởi 6-OHDA gây ra. Những phát hiện của chúng tôi có thể được khai thác tiềm năng cho việc phát triển các chiến lược điều trị mới chống lại PD.",{"EN":5315,"VI":5316},"Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats","Quản lý Môi trường Nước: Các Giải pháp Bền vững cho Tương lai",{"VOID":5318},"30706999",{"VOID":5196},[102],[101],"https:\u002F\u002Facademic.oup.com\u002Fstcltm\u002Farticle\u002F8\u002F5\u002F490\u002F6403745",[5324,5343,5360,5377,5398,5415,5432,5449,5466,5483,5500],{"id":5325,"sortIndex":158,"researcher":26,"roles":5326,"affiliations":5327,"properties":5338},"e4f98c28-fb49-4e5b-aee6-66588a43a25e",[],[5328],{"id":5329,"sortIndex":36,"affiliation":5330,"properties":26},"00543672-74b9-4c8d-b0a7-71b3a4f82231",{"id":5331,"createTime":5332,"updateTime":5332,"relativeEntities":5333,"slug":5334,"properties":5335,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"5a4d3709-8425-47e7-b70e-397119c0797f","2024-10-01T09:54:54.200+00:00",[],"bDepartment-of-Stem-Cell-Biology-State-Research-Institute-Centre-for-Innovative-Medicine-Vilnius-Lithuania",{"title":5336},{"EN":5337},"bDepartment of Stem Cell Biology State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania",{"openalex":5339,"title":5341},{"VOID":5340},"A5012953656",{"EN":5342},"Akvilė Jarmalavičiūtė",{"id":5344,"sortIndex":135,"researcher":26,"roles":5345,"affiliations":5346,"properties":5353},"8ef67576-d913-4072-864d-97013ca175da",[],[5347],{"id":5348,"sortIndex":36,"affiliation":5349,"properties":26},"1d594801-d609-433f-be63-22833692f421",{"id":5331,"createTime":5332,"updateTime":5332,"relativeEntities":5350,"slug":5334,"properties":5351,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5352},{"EN":5337},{"openalex":5354,"orcid":5356,"title":5358},{"VOID":5355},"A5027055410",{"VOID":5357},"https:\u002F\u002Forcid.org\u002F0000-0003-2879-7595",{"EN":5359},"Karolina Kriaučiūnaitė",{"id":5361,"sortIndex":162,"researcher":26,"roles":5362,"affiliations":5363,"properties":5370},"dcea5725-cb5c-48ae-9467-ee47dee27f03",[],[5364],{"id":5365,"sortIndex":36,"affiliation":5366,"properties":26},"665fa543-7b32-45fd-9957-6249ff367a42",{"id":5331,"createTime":5332,"updateTime":5332,"relativeEntities":5367,"slug":5334,"properties":5368,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5369},{"EN":5337},{"openalex":5371,"orcid":5373,"title":5375},{"VOID":5372},"A5090406358",{"VOID":5374},"https:\u002F\u002Forcid.org\u002F0000-0002-9442-161X",{"EN":5376},"Virginijus Tunaitis",{"id":5378,"sortIndex":36,"researcher":26,"roles":5379,"affiliations":5380,"properties":5391},"e8f85837-0bee-45f1-ab30-d3539fe75c30",[],[5381],{"id":5382,"sortIndex":36,"affiliation":5383,"properties":26},"2007cfdf-6a55-4fae-b3e6-75924e241dac",{"id":5384,"createTime":5385,"updateTime":5385,"relativeEntities":5386,"slug":5387,"properties":5388,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"cd490045-c0e7-48a5-bcd5-8437eb87e7f8","2024-10-01T09:54:54.214+00:00",[],"aDepartment-of-Pharmacology-Faculty-of-Medicine-University-of-Latvia-Riga-Latvia",{"title":5389},{"EN":5390},"aDepartment of Pharmacology, Faculty of Medicine University of Latvia, Riga, Latvia",{"openalex":5392,"orcid":5394,"title":5396},{"VOID":5393},"A5017338915",{"VOID":5395},"https:\u002F\u002Forcid.org\u002F0000-0002-5358-6194",{"EN":5397},"Karīna Narbute",{"id":5399,"sortIndex":111,"researcher":26,"roles":5400,"affiliations":5401,"properties":5408},"48e4aafb-1227-4ab6-93d1-4ec1b4b24904",[],[5402],{"id":5403,"sortIndex":36,"affiliation":5404,"properties":26},"1f713a2c-8431-4dbf-8a56-a686c5e087ae",{"id":5331,"createTime":5332,"updateTime":5332,"relativeEntities":5405,"slug":5334,"properties":5406,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5407},{"EN":5337},{"openalex":5409,"orcid":5411,"title":5413},{"VOID":5410},"A5065547632",{"VOID":5412},"https:\u002F\u002Forcid.org\u002F0000-0002-4882-7918",{"EN":5414},"Ugnė Jonavičė",{"id":5416,"sortIndex":52,"researcher":26,"roles":5417,"affiliations":5418,"properties":5425},"ff50f702-e064-43b3-bdb3-481c0033aeab",[],[5419],{"id":5420,"sortIndex":36,"affiliation":5421,"properties":26},"52dcbd96-d931-475d-a990-7bb1abc01aa6",{"id":5384,"createTime":5385,"updateTime":5385,"relativeEntities":5422,"slug":5387,"properties":5423,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5424},{"EN":5390},{"openalex":5426,"orcid":5428,"title":5430},{"VOID":5427},"A5033285509",{"VOID":5429},"https:\u002F\u002Forcid.org\u002F0000-0003-3263-8001",{"EN":5431},"Vija Kluša",{"id":5433,"sortIndex":59,"researcher":26,"roles":5434,"affiliations":5435,"properties":5442},"924db53a-40e8-4e87-9ac7-45174b26a808",[],[5436],{"id":5437,"sortIndex":36,"affiliation":5438,"properties":26},"f03d907b-bb07-4979-ad69-561a47f159fd",{"id":5384,"createTime":5385,"updateTime":5385,"relativeEntities":5439,"slug":5387,"properties":5440,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5441},{"EN":5390},{"openalex":5443,"orcid":5445,"title":5447},{"VOID":5444},"A5070492707",{"VOID":5446},"https:\u002F\u002Forcid.org\u002F0000-0002-1903-9883",{"EN":5448},"Zane Dzirkale",{"id":5450,"sortIndex":50,"researcher":26,"roles":5451,"affiliations":5452,"properties":5459},"ba6bf1a4-032b-459a-824e-676e545ae99e",[],[5453],{"id":5454,"sortIndex":36,"affiliation":5455,"properties":26},"e0ed74dd-77fb-4ce7-97b8-a4321e659831",{"id":5384,"createTime":5385,"updateTime":5385,"relativeEntities":5456,"slug":5387,"properties":5457,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5458},{"EN":5390},{"openalex":5460,"orcid":5462,"title":5464},{"VOID":5461},"A5040908974",{"VOID":5463},"https:\u002F\u002Forcid.org\u002F0000-0002-4062-3363",{"EN":5465},"Baiba Jansone",{"id":5467,"sortIndex":115,"researcher":26,"roles":5468,"affiliations":5469,"properties":5476},"84b7a7a1-dc51-4831-b147-2f55c7b71b5e",[],[5470],{"id":5471,"sortIndex":36,"affiliation":5472,"properties":26},"5c33444b-7451-4bbc-9f5c-56ac4483ef1b",{"id":5384,"createTime":5385,"updateTime":5385,"relativeEntities":5473,"slug":5387,"properties":5474,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5475},{"EN":5390},{"openalex":5477,"orcid":5479,"title":5481},{"VOID":5478},"A5054781419",{"VOID":5480},"https:\u002F\u002Forcid.org\u002F0000-0002-7098-7483",{"EN":5482},"Vladimirs Piļipenko",{"id":5484,"sortIndex":116,"researcher":26,"roles":5485,"affiliations":5486,"properties":5493},"ef18f20c-b82f-45fa-9838-58cdc3e77c27",[],[5487],{"id":5488,"sortIndex":36,"affiliation":5489,"properties":26},"9e2da36b-19bf-4720-be8f-a1e9c26d171e",{"id":5331,"createTime":5332,"updateTime":5332,"relativeEntities":5490,"slug":5334,"properties":5491,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5492},{"EN":5337},{"openalex":5494,"orcid":5496,"title":5498},{"VOID":5495},"A5032895233",{"VOID":5497},"https:\u002F\u002Forcid.org\u002F0000-0001-7009-2535",{"EN":5499},"Augustas Pivoriūnas",{"id":5501,"sortIndex":114,"researcher":26,"roles":5502,"affiliations":5503,"properties":5510},"d3fcf76c-3a68-4371-a669-63ced34acca2",[],[5504],{"id":5505,"sortIndex":36,"affiliation":5506,"properties":26},"4839f292-4d4c-4232-86f9-44b579fa8cc5",{"id":5384,"createTime":5385,"updateTime":5385,"relativeEntities":5507,"slug":5387,"properties":5508,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5509},{"EN":5390},{"openalex":5511,"orcid":5513,"title":5515},{"VOID":5512},"A5059130836",{"VOID":5514},"https:\u002F\u002Forcid.org\u002F0000-0001-8356-5071",{"EN":5516},"Jolanta Pupure",{"url":26,"publisher":5518,"properties":5543},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":5519,"slug":663,"properties":5520,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":5526,"manageAffiliations":5527,"indexDatabases":5528,"url":762,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":5521,"issn":5522,"introduce":5523,"eissn":5524,"title":5525},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[5529,5536],{"id":742,"indexDatabase":5530,"url":755,"indexYears":756,"academicFieldIds":5535,"indexDatabaseRanking":761},{"id":744,"createTime":745,"updateTime":746,"relativeEntities":5531,"label":5532,"description":5533,"key":752,"publicationTags":5534,"standard":26},[],{"EN":749,"VI":749},{"EN":749,"VI":751},[754],[758,759,760],{"id":723,"indexDatabase":5537,"url":738,"indexYears":26,"academicFieldIds":5542,"indexDatabaseRanking":26},{"id":725,"createTime":726,"updateTime":727,"relativeEntities":5538,"label":5539,"description":5540,"key":734,"publicationTags":5541,"standard":26},[],{"EN":730,"VI":730},{"VI":732,"EN":733},[736,737],[740],{"volume":5544,"pages":5546,"issue":5548},{"VOID":5545},"8",{"VOID":5547},"490-499",{"VOID":5549},"5",116,{"total":5550,"publishYear":26,"statisticByYear":5552},{"2017":115,"2019":158,"2020":241,"2021":516,"2022":238,"2023":260,"2024":53},"2019-05-01",2019,[5556,5560,5564,5568,5572,5576,5580,5584,5588,5592,5596,5598,5602,5606,5610,5614,5617,5621,5624,5628,5632,5636,5640,5644,5647,5651,5655,5659,5663,5667,5671,5675,5679,5683,5687,5691,5695,5699,5703,5707,5711,5715,5719,5723],{"id":26,"text":5557,"url":26,"identifiers":5558},"Shulman, 2011, Parkinson's disease: Genetics and pathogenesis, Annu Rev Pathol, 6, 193, 10.1146\u002Fannurev-pathol-011110-130242",{"doi":5559},"10.1146\u002Fannurev-pathol-011110-130242",{"id":26,"text":5561,"url":26,"identifiers":5562},"Cheng, 2010, Clinical progression in Parkinson disease and the neurobiology of axons, Ann Neurol, 67, 715, 10.1002\u002Fana.21995",{"doi":5563},"10.1002\u002Fana.21995",{"id":26,"text":5565,"url":26,"identifiers":5566},"Kirkeby, 2012, Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions, Cell Rep, 1, 703, 10.1016\u002Fj.celrep.2012.04.009",{"doi":5567},"10.1016\u002Fj.celrep.2012.04.009",{"id":26,"text":5569,"url":26,"identifiers":5570},"Kriks, 2011, Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease, Nature, 480, 547, 10.1038\u002Fnature10648",{"doi":5571},"10.1038\u002Fnature10648",{"id":26,"text":5573,"url":26,"identifiers":5574},"Barker, 2017, Human trials of stem cell-derived dopamine neurons for Parkinson's disease: Dawn of a new era, Cell Stem Cell, 21, 569, 10.1016\u002Fj.stem.2017.09.014",{"doi":5575},"10.1016\u002Fj.stem.2017.09.014",{"id":26,"text":5577,"url":26,"identifiers":5578},"Kourembanas, 2015, Exosomes: Vehicles of intercellular signaling, biomarkers, and vectors of cell therapy, Annu Rev Physiol, 77, 13, 10.1146\u002Fannurev-physiol-021014-071641",{"doi":5579},"10.1146\u002Fannurev-physiol-021014-071641",{"id":26,"text":5581,"url":26,"identifiers":5582},"Maas, 2017, Extracellular vesicles: Unique intercellular delivery vehicles, Trends Cell Biol, 27, 172, 10.1016\u002Fj.tcb.2016.11.003",{"doi":5583},"10.1016\u002Fj.tcb.2016.11.003",{"id":26,"text":5585,"url":26,"identifiers":5586},"Alvarez-Erviti, 2011, Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat Biotechnol, 29, 341, 10.1038\u002Fnbt.1807",{"doi":5587},"10.1038\u002Fnbt.1807",{"id":26,"text":5589,"url":26,"identifiers":5590},"Yang, 2015, Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio rerio, Pharm Res, 32, 2003, 10.1007\u002Fs11095-014-1593-y",{"doi":5591},"10.1007\u002Fs11095-014-1593-y",{"id":26,"text":5593,"url":26,"identifiers":5594},"Gyorgy, 2015, Therapeutic applications of extracellular vesicles: Clinical promise and open questions, Annu Rev Pharmacol Toxicol, 55, 439, 10.1146\u002Fannurev-pharmtox-010814-124630",{"doi":5595},"10.1146\u002Fannurev-pharmtox-010814-124630",{"id":26,"text":5067,"url":26,"identifiers":5597},{"doi":5069},{"id":26,"text":5599,"url":26,"identifiers":5600},"Kim, 2016, Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI, Proc Natl Acad Sci USA, 113, 170, 10.1073\u002Fpnas.1522297113",{"doi":5601},"10.1073\u002Fpnas.1522297113",{"id":26,"text":5603,"url":26,"identifiers":5604},"Haney, 2013, Specific transfection of inflamed brain by macrophages: A new therapeutic strategy for neurodegenerative diseases, PLoS One, 8, e61852, 10.1371\u002Fjournal.pone.0061852",{"doi":5605},"10.1371\u002Fjournal.pone.0061852",{"id":26,"text":5607,"url":26,"identifiers":5608},"Sun, 2010, A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes, Mol Ther, 18, 1606, 10.1038\u002Fmt.2010.105",{"doi":5609},"10.1038\u002Fmt.2010.105",{"id":26,"text":5611,"url":26,"identifiers":5612},"Kaukua, 2014, Glial origin of mesenchymal stem cells in a tooth model system, Nature, 513, 551, 10.1038\u002Fnature13536",{"doi":5613},"10.1038\u002Fnature13536",{"id":26,"text":5615,"url":26,"identifiers":5616},"Sakai, 2012, Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms, J Clin Invest, 122, 80",{},{"id":26,"text":5618,"url":26,"identifiers":5619},"Jarmalaviciute, 2013, A new experimental model for neuronal and glial differentiation using stem cells derived from human exfoliated deciduous teeth, J Mol Neurosci, 51, 307, 10.1007\u002Fs12031-013-0046-0",{"doi":5620},"10.1007\u002Fs12031-013-0046-0",{"id":26,"text":5622,"url":26,"identifiers":5623},"Fujii, 1613, Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats, Brain Res, 2015, 59",{},{"id":26,"text":5625,"url":26,"identifiers":5626},"Martens, 2014, Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro, FASEB J, 28, 1634, 10.1096\u002Ffj.13-243980",{"doi":5627},"10.1096\u002Ffj.13-243980",{"id":26,"text":5629,"url":26,"identifiers":5630},"Jarmalaviciute, 2015, Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine-induced apoptosis, Cytotherapy, 17, 932, 10.1016\u002Fj.jcyt.2014.07.013",{"doi":5631},"10.1016\u002Fj.jcyt.2014.07.013",{"id":26,"text":5633,"url":26,"identifiers":5634},"Zhou, 2015, Gait analysis in three different 6-hydroxydopamine rat models of Parkinson's disease, Neurosci Lett, 584, 184, 10.1016\u002Fj.neulet.2014.10.032",{"doi":5635},"10.1016\u002Fj.neulet.2014.10.032",{"id":26,"text":5637,"url":26,"identifiers":5638},"Hamers, 2006, CatWalk-assisted gait analysis in the assessment of spinal cord injury, J Neurotrauma, 23, 537, 10.1089\u002Fneu.2006.23.537",{"doi":5639},"10.1089\u002Fneu.2006.23.537",{"id":26,"text":5641,"url":26,"identifiers":5642},"Gabriel, 2007, The CatWalk method: A detailed analysis of behavioral changes after acute inflammatory pain in the rat, J Neurosci Methods, 163, 9, 10.1016\u002Fj.jneumeth.2007.02.003",{"doi":5643},"10.1016\u002Fj.jneumeth.2007.02.003",{"id":26,"text":5645,"url":26,"identifiers":5646},"Thery, 2006, Isolation and characterization of exosomes from cell culture supernatants and biological fluids, Curr Protoc Cell Biol, 10.1002\u002F0471143030.cb0322s30",{"doi":5015},{"id":26,"text":5648,"url":26,"identifiers":5649},"Kalra, 2012, Vesiclepedia: A compendium for extracellular vesicles with continuous community annotation, PLoS Biol, 10, 10.1371\u002Fjournal.pbio.1001450",{"doi":5650},"10.1371\u002Fjournal.pbio.1001450",{"id":26,"text":5652,"url":26,"identifiers":5653},"Boix, 2018, Gait analysis for early detection of motor symptoms in the 6-OHDA rat model of Parkinson's disease, Front Behav Neurosci, 12, 39, 10.3389\u002Ffnbeh.2018.00039",{"doi":5654},"10.3389\u002Ffnbeh.2018.00039",{"id":26,"text":5656,"url":26,"identifiers":5657},"Henning, 2008, Differential astroglial activation in 6-hydroxydopamine models of Parkinson's disease, Neurosci Res, 62, 246, 10.1016\u002Fj.neures.2008.09.001",{"doi":5658},"10.1016\u002Fj.neures.2008.09.001",{"id":26,"text":5660,"url":26,"identifiers":5661},"Boix, 2015, A partial lesion model of Parkinson's disease in mice—Characterization of a 6-OHDA-induced medial forebrain bundle lesion, Behav Brain Res, 284, 196, 10.1016\u002Fj.bbr.2015.01.053",{"doi":5662},"10.1016\u002Fj.bbr.2015.01.053",{"id":26,"text":5664,"url":26,"identifiers":5665},"Ma, 2014, The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats, Behav Brain Res, 266, 37, 10.1016\u002Fj.bbr.2014.02.039",{"doi":5666},"10.1016\u002Fj.bbr.2014.02.039",{"id":26,"text":5668,"url":26,"identifiers":5669},"Blandini, 2008, The 6-hydroxydopamine model: News from the past, Parkinsonism Relat Disord, 14, S124, 10.1016\u002Fj.parkreldis.2008.04.015",{"doi":5670},"10.1016\u002Fj.parkreldis.2008.04.015",{"id":26,"text":5672,"url":26,"identifiers":5673},"Schober, 2004, Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP, Cell Tissue Res, 318, 215, 10.1007\u002Fs00441-004-0938-y",{"doi":5674},"10.1007\u002Fs00441-004-0938-y",{"id":26,"text":5676,"url":26,"identifiers":5677},"Mazzio, 2004, The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro, Brain Res, 1004, 29, 10.1016\u002Fj.brainres.2003.12.034",{"doi":5678},"10.1016\u002Fj.brainres.2003.12.034",{"id":26,"text":5680,"url":26,"identifiers":5681},"Botella, 2008, Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease, Neurobiol Dis, 30, 65, 10.1016\u002Fj.nbd.2007.11.013",{"doi":5682},"10.1016\u002Fj.nbd.2007.11.013",{"id":26,"text":5684,"url":26,"identifiers":5685},"Calabrese, 2011, Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity, Mol Aspects Med, 32, 279, 10.1016\u002Fj.mam.2011.10.007",{"doi":5686},"10.1016\u002Fj.mam.2011.10.007",{"id":26,"text":5688,"url":26,"identifiers":5689},"Dong, 2005, Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease, Mol Ther, 11, 80, 10.1016\u002Fj.ymthe.2004.09.007",{"doi":5690},"10.1016\u002Fj.ymthe.2004.09.007",{"id":26,"text":5692,"url":26,"identifiers":5693},"Ekimova, 2018, New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease, Exp Neurol, 306, 199, 10.1016\u002Fj.expneurol.2018.04.012",{"doi":5694},"10.1016\u002Fj.expneurol.2018.04.012",{"id":26,"text":5696,"url":26,"identifiers":5697},"Cunningham, 2015, Anti-inflammatory peptide regulates the supply of heat shock protein 70 monomers: Implications for aging and age-related disease, Rejuvenation Res, 18, 136, 10.1089\u002Frej.2014.1620",{"doi":5698},"10.1089\u002Frej.2014.1620",{"id":26,"text":5700,"url":26,"identifiers":5701},"Wang, 2009, 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: Localization of dopamine regulatory proteins to mitochondria, J Biol Chem, 284, 14011, 10.1074\u002Fjbc.M901310200",{"doi":5702},"10.1074\u002Fjbc.M901310200",{"id":26,"text":5704,"url":26,"identifiers":5705},"Obsilova, 2008, The 14-3-3 protein affects the conformation of the regulatory domain of human tyrosine hydroxylase, Biochemistry, 47, 1768, 10.1021\u002Fbi7019468",{"doi":5706},"10.1021\u002Fbi7019468",{"id":26,"text":5708,"url":26,"identifiers":5709},"Korshunova, 2008, Characterization of BASP1-mediated neurite outgrowth, J Neurosci Res, 86, 2201, 10.1002\u002Fjnr.21678",{"doi":5710},"10.1002\u002Fjnr.21678",{"id":26,"text":5712,"url":26,"identifiers":5713},"Caraveo, 2017, FKBP12 contributes to alpha-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome, Proc Natl Acad Sci USA, 114, E11313, 10.1073\u002Fpnas.1711926115",{"doi":5714},"10.1073\u002Fpnas.1711926115",{"id":26,"text":5716,"url":26,"identifiers":5717},"Mirsaeidi, 2016, Annexins family: Insights into their functions and potential role in pathogenesis of sarcoidosis, J Transl Med, 14, 89, 10.1186\u002Fs12967-016-0843-7",{"doi":5718},"10.1186\u002Fs12967-016-0843-7",{"id":26,"text":5720,"url":26,"identifiers":5721},"Perretti, 2009, Annexin A1 and glucocorticoids as effectors of the resolution of inflammation, Nat Rev Immunol, 9, 62, 10.1038\u002Fnri2470",{"doi":5722},"10.1038\u002Fnri2470",{"id":26,"text":5724,"url":26,"identifiers":5725},"Han, 2004, Effects of annexins II and V on survival of neurons and astrocytes in vitro, Acta Pharmacol Sin, 25, 602",{}]