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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":611,"VI":612},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":614},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[618],{"id":619,"createTime":18,"updateTime":18,"relativeEntities":620,"slug":18,"properties":621,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":631,"parentIds":632,"statistic":18},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":622,"address":625,"country":628,"abbreviation":629},{"EN":623,"VI":624},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":626,"VI":627},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":168},{"VOID":630},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":19,"impactFactorByYear":636,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":638,"totalPublicationByYear":639,"totalCitation":644,"totalCitationByYear":645,"totalCitationPerPublication":104,"totalCitationPerPublicationByYear":647,"hindexLast5Year":195,"hindex":195},{"2022":637,"2023":257,"2024":253},0.01,1556,{"2020":120,"2021":640,"2022":641,"2023":642,"2024":643,"2025":266},57,306,801,358,161,{"2021":282,"2022":409,"2023":646},99,{"2021":648,"2022":447,"2023":105},0.23,{"impactFactor":18,"impactFactorByYear":18,"i10Index":267,"i10IndexLast5Year":267,"totalPublication":650,"totalPublicationByYear":651,"totalCitation":650,"totalCitationByYear":652,"totalCitationPerPublication":190,"totalCitationPerPublicationByYear":655,"hindexLast5Year":198,"hindex":198},476,{"0":335,"2019":267,"2021":276,"2022":584,"2023":576,"2024":484,"2025":198,"2026":197},{"2021":192,"2022":267,"2023":294,"2024":653,"2025":487,"2026":654},136,83,{"2021":252,"2022":637,"2023":656,"2024":113,"2025":657,"2026":658},0.62,25.43,13.83,{"id":660,"createTime":661,"updateTime":509,"relativeEntities":662,"slug":663,"properties":664,"entityType":16,"verifyStatus":178,"verifyTime":18,"verifyNote":18,"languages":676,"translateLanguages":18,"viewCount":122,"subjectFields":677,"manageAffiliations":678,"indexDatabases":679,"url":680,"thumbnailPath":681,"statistic":682,"gsStatistic":717,"type":203,"analyzePriority":18},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":665,"issn":666,"title":668,"introduce":671,"gsId":674},{"VOID":168},{"VOID":667},"25252445",{"EN":669,"VI":670},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":672,"VI":673},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. Since then, the journal has grown in quality, size and scope and now comprises a dozen of serials spanning academic research. 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Although, the main text structure may vary based on the review subtopics, the articles should be formatted according to suitable Templates as research articles.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Tạp chí Khoa học Trường ĐHSP Hà Nội 2 nhằm mục đích cung cấp một nền tảng liên ngành của sự phổ biến những tiến bộ của khoa học và công nghệ. Tạp chí xuất bản các bài báo gốc có giá trị khoa học hoặc công nghệ trong tất cả các lĩnh vực khoa học tự nhiên, xã hội hoặc giáo dục.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học tự nhiên và công nghệ:\"},{\"insert\":\" Là các bài báo mô tả những phát hiện có giá trị trong vật lý, toán học, hóa học, sinh học; giải quyết các vấn đề kỹ thuật hoặc công nghệ.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học Xã hội và Nhân văn:\"},{\"insert\":\" là các bài báo xuất bản chất lượng cao trong các lĩnh vực khác nhau của khoa học xã hội và nghiên cứu phát triển con người.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Chuyên san Khoa học giáo dục:\"},{\"insert\":\" là các bài báo xuất bản trong lĩnh vực khoa học giáo dục và các ứng dụng của tiến bộ vào giáo dục để cải thiện và nâng cao giáo dục khoa học ở tất cả các cấp.\"},{\"attributes\":{\"list\":\"bullet\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí trường ĐHSP Hà Nội 2 xuất bản được phản biện kín, xét duyệt bởi ít nhất 02 chuyên gia, và được đánh giá, chọn lựa từ ban biên tập và Tổng biên tập.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Các loại bài báo\"},{\"insert\":\":\\nBài báo nghiên cứu:\"},{\"attributes\":{\"list\":\"ordered\"},\"insert\":\"\\n\"},{\"insert\":\"Báo cáo học thuật về nghiên cứu ban đầu chưa từng được xuất bản ở bất kỳ nơi nào, hay bằng bất kỳ ngôn ngữ nào khác. Bản thảo thích hợp, nên chứa các phần sau theo thứ tự: Tiêu đề, Tác giả, Liên kết tác giả, Địa chỉ email của tác giả tương ứng, Tóm tắt, Từ khóa, Danh pháp (nếu có), Giới thiệu, Thử nghiệm, Lý thuyết, Kết quả và thảo luận, Kết luận, Xung đột quan tâm, Lời cảm ơn (nếu có), Tài liệu tham khảo, Phụ lục (nếu có). Bản xuất bản trước phải được định dạng theo Mẫu (phiên bản MS-Word).\\n2. Bài báo tổng quan:\\nNgoài các bài phê bình được mời, các bài phê bình tài liệu, bài phê bình có hệ thống và bài phê bình sẽ được chấp nhận để xem xét. Bản thảo cần được soạn thảo và sắp xếp theo trình tự yêu cầu: Tên sách, Tên tác giả, Liên kết, Địa chỉ email, Tóm tắt, Từ khóa, Nội dung chính, Kết luận, Xung đột lợi ích, Lời cảm ơn (nếu có), Tài liệu tham khảo. Mặc dù, cấu trúc văn bản chính có thể thay đổi dựa trên các chủ đề phụ của bài đánh giá, các bài báo nên được định dạng theo các Mẫu phù hợp như các bài báo nghiên cứu.\\n\"}]}",{"VOID":845},"YPoBvsIAAAAJ",[],[],[],"https:\u002F\u002Fsj.hpu2.edu.vn\u002Findex.php\u002Fjournal","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F954132b5-ca74-461c-b819-45ad6e49a404\u002F2790ef1d0a7d7a40a504c2fc1647f670.jpg",{"impactFactor":19,"impactFactorByYear":852,"i10Index":19,"i10IndexLast5Year":19,"totalPublication":136,"totalPublicationByYear":854,"totalCitation":272,"totalCitationByYear":855,"totalCitationPerPublication":648,"totalCitationPerPublicationByYear":856,"hindexLast5Year":267,"hindex":267},{"2024":853},0.17,{"2022":273,"2023":407,"2024":278},{"2022":484,"2023":116,"2024":267},{"2022":302,"2023":354,"2024":298},{"impactFactor":18,"impactFactorByYear":18,"i10Index":195,"i10IndexLast5Year":195,"totalPublication":458,"totalPublicationByYear":858,"totalCitation":287,"totalCitationByYear":859,"totalCitationPerPublication":860,"totalCitationPerPublicationByYear":861,"hindexLast5Year":196,"hindex":196},{"0":267,"2022":272,"2023":273,"2024":217,"2025":281},{"2023":196,"2024":273,"2025":331,"2026":407},1.22,{"2023":259,"2024":467,"2025":862},4.56,{"id":864,"createTime":865,"updateTime":866,"relativeEntities":867,"slug":868,"properties":869,"entityType":16,"verifyStatus":178,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":217,"subjectFields":881,"manageAffiliations":882,"indexDatabases":890,"url":930,"thumbnailPath":18,"statistic":931,"gsStatistic":963,"type":203,"analyzePriority":18},"21ccdb34-414d-420f-8a60-a592a2fa848e","2023-05-29T10:42:53.358+00:00","2026-08-27T01:57:29.560+00:00",[],"Vietnam-Journal-of-Earth-Sciences",{"country":870,"eissn":871,"issn":873,"title":875,"introduce":877,"gsId":879},{"VOID":168},{"VOID":872},"26159783",{"VOID":874},"08667187",{"EN":876},"Vietnam Journal of Earth Sciences",{"EN":878},"Science of the Earth, formerly Vietnam Journal of Earth Sciences, is a peer-reviewed journal to publish high-quality articles on the entire range of earth sciences and the environment, focused on the Asia Pacific region and their correlations and connections to the globe. 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In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by which opioids relieve pain and induce euphoria is dependent on the drug crossing the blood–brain barrier and accessing the central nervous system. This suggests the blood brain barrier plays a central role in both the benefits and risks of opioid use. The complex physiological responses to opioids that provide the benefits and drive the abuse also needs to be considered in the resolution of the opioid epidemic.",{"EN":990},"The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse",{"VOID":992},"United States Department of Health and Human Services. The opioid epidemic: by the numbers. 2016;60. http:\u002F\u002Fwww.hhs.gov\u002Fsites\u002Fdefault\u002Ffiles\u002FFactsheet-opioids-061516.pdf. Accessed 6 June 2016.\nRudd RA, Aleshire N, Zibbell JE, Gladden RM. Increases in drug and opioid overdose deaths—United States, 2000–2014. 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Pain. 2017;158:347–60.",{"VOID":994},"10.1186\u002Fs12987-017-0080-3","PUBLICATION","https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12987-017-0080-3",[998,1014,1027],{"id":999,"sortIndex":19,"researcher":18,"roles":1000,"affiliations":1002,"properties":1011,"displayName":1013,"givenName":18,"familyName":18},"c9279987-bc1c-4c8b-b298-9e1785d42bee",[1001],"AUTHOR",[1003],{"id":1004,"sortIndex":19,"affiliation":1005,"properties":18},"5a5a7822-1836-4bf2-b3ed-4bd2ed8e4138",{"id":1004,"createTime":18,"updateTime":18,"relativeEntities":1006,"slug":18,"properties":1007,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1010,"statistic":18},[],{"title":1008},{"VI":1009},"Department of Pharmacology, University of Arizona, Tucson, USA",[],{"title":1012},{"VI":1013},"Charles P. Schaefer",{"id":1015,"sortIndex":190,"researcher":18,"roles":1016,"affiliations":1017,"properties":1024,"displayName":1026,"givenName":18,"familyName":18},"a20664a8-29c5-48e1-9ef6-e10b4edfc735",[1001],[1018],{"id":1004,"sortIndex":19,"affiliation":1019,"properties":18},{"id":1004,"createTime":18,"updateTime":18,"relativeEntities":1020,"slug":18,"properties":1021,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1023,"statistic":18},[],{"title":1022},{"VI":1009},[],{"title":1025},{"VI":1026},"Margaret E. Tome",{"id":1028,"sortIndex":267,"researcher":18,"roles":1029,"affiliations":1030,"properties":1037,"displayName":1039,"givenName":18,"familyName":18},"f45c95e2-ebce-4da0-92b4-88272dfd3cb4",[1001],[1031],{"id":1004,"sortIndex":19,"affiliation":1032,"properties":18},{"id":1004,"createTime":18,"updateTime":18,"relativeEntities":1033,"slug":18,"properties":1034,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1036,"statistic":18},[],{"title":1035},{"VI":1009},[],{"title":1038},{"VI":1039},"Thomas P. Davis","ARTICLE",{"url":996,"publisher":1042,"properties":1095},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1043,"slug":10,"properties":1044,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1047,"manageAffiliations":1064,"indexDatabases":1075,"url":18,"thumbnailPath":18,"statistic":1090,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":1045,"title":1046},{"VOID":13},{"EN":15},[1048,1052,1056,1060],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1049,"label":1050,"description":1051,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1053,"label":1054,"description":1055,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},{"id":34,"createTime":18,"updateTime":18,"relativeEntities":1057,"label":1058,"description":1059,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":37},{},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":1061,"label":1062,"description":1063,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":43},{},[1065,1070],{"id":47,"createTime":18,"updateTime":18,"relativeEntities":1066,"slug":18,"properties":1067,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1069,"statistic":18},[],{"title":1068},{"EN":51},[],{"id":54,"createTime":18,"updateTime":18,"relativeEntities":1071,"slug":18,"properties":1072,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1074,"statistic":18},[],{"title":1073},{"EN":58},[],[1076,1083],{"id":62,"indexDatabase":1077,"url":75,"indexYears":18,"academicFieldIds":1082,"indexDatabaseRanking":18},{"id":64,"createTime":18,"updateTime":18,"relativeEntities":1078,"label":1079,"description":1080,"key":71,"publicationTags":1081,"standard":18},[],{"EN":67,"VI":67},{"EN":69,"VI":70},[73,74],[77],{"id":79,"indexDatabase":1084,"url":90,"indexYears":91,"academicFieldIds":1089,"indexDatabaseRanking":97},{"id":81,"createTime":18,"updateTime":18,"relativeEntities":1085,"label":1086,"description":1087,"key":87,"publicationTags":1088,"standard":18},[],{"EN":84,"VI":84},{"EN":84,"VI":86},[89],[93,94,95,96],{"impactFactor":19,"impactFactorByYear":1091,"i10Index":112,"i10IndexLast5Year":113,"totalPublication":114,"totalPublicationByYear":1092,"totalCitation":128,"totalCitationByYear":1093,"totalCitationPerPublication":141,"totalCitationPerPublicationByYear":1094,"hindexLast5Year":155,"hindex":155},{"2012":100,"2013":101,"2014":102,"2015":103,"2016":104,"2017":105,"2018":106,"2019":107,"2020":108,"2021":109,"2022":110,"2023":111},{"2011":113,"2012":116,"2013":117,"2014":118,"2015":119,"2016":120,"2017":117,"2018":121,"2019":122,"2020":123,"2021":124,"2022":125,"2023":126,"2024":127},{"2011":130,"2012":131,"2013":132,"2014":133,"2015":134,"2016":112,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140},{"2011":143,"2012":144,"2013":145,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":1096,"volume":1098},{"VOID":1097},"1-11",{"VOID":1099},"14","2017-11-29",2017,[97,73],false,{"id":1105,"createTime":1106,"updateTime":1107,"relativeEntities":1108,"slug":1109,"properties":1110,"entityType":995,"verifyStatus":178,"verifyTime":1107,"verifyNote":1119,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1120,"fullTextUrl":18,"authors":1121,"publicationType":1040,"publisherRelationship":1263,"citationCount":18,"citationInfo":18,"publishDate":1322,"publishYear":1323,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":1324,"openAccess":18,"references":18,"isForceReanalyzing":1103},"013ade4d-3a98-473a-9164-80e641930db2","2024-01-05T17:03:40.359+00:00","2024-12-29T00:54:08.850+00:00",[],"The-choroid-plexus-a-door-between-the-blood-and-the-brain-for-tissue-type-plasminogen-activator",{"abstract":1111,"title":1113,"references":1115,"doi":1117},{"EN":1112},"In the vascular compartment, the serine protease tissue-type plasminogen activator (tPA) promotes fibrinolysis, justifying its clinical use against vasculo-occlusive diseases. Accumulating evidence shows that circulating tPA (endogenous or exogenous) also controls brain physiopathological processes, like cerebrovascular reactivity, blood–brain barrier (BBB) homeostasis, inflammation and neuronal fate. Whether this occurs by direct actions on parenchymal cells and\u002For indirectly via barriers between the blood and the central nervous system (CNS) remains unclear. Here, we postulated that vascular tPA can reach the brain parenchyma via the blood-cerebrospinal fluid barrier (BCSFB), that relies on choroid plexus (CP) epithelial cells (CPECs). We produced various reporter fusion proteins to track tPA in primary cultures of CPECs, in CP explants and in vivo in mice. We also investigated the mechanisms underlying tPA transport across the BCSFB, with pharmacological and molecular approaches. We first demonstrated that tPA can be internalized by CPECs in primary cultures and in ex vivo CPs explants. In vivo, tPA can also be internalized by CPECs both at their basal and apical sides. After intra-vascular administration, tPA can reach the cerebral spinal fluid (CSF) and the brain parenchyma. Further investigation allowed discovering that the transcytosis of tPA is mediated by Low-density-Lipoprotein Related Protein-1 (LRP1) expressed at the surface of CPECs and depends on the finger domain of tPA. Interestingly, albumin, which has a size comparable to that of tPA, does not normally cross the CPs, but switches to a transportable form when grafted to the finger domain of tPA. These findings provide new insights on how vascular tPA can reach the brain parenchyma, and open therapeutic avenues for CNS disorders.",{"EN":1114},"The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator",{"VOID":1116},"Anfray A, Drieu A, Hingot V, Hommet Y, Yetim M, Rubio M, Deffieux T, Tanter M, Orset C, Vivien D. 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Int J Mol Sci. 2021;22(12):6442. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fijms22126442.\nKung Y, Chen KY, Liao WH, Hsu YH, Wu CH, Hsiao MY, Huang APH, Chen WS. Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse. Fluids Barriers CNS. 2022;19(1):1–13. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12987-021-00303-x.\nLazarevic I, Engelhardt B. Modeling immune functions of the mouse blood–cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. Fluids Barriers CNS. 2015;13(1):2. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12987-016-0027-0.\nLevin EG, Santell L, Osborn KG. The expression of endothelial tissue plasminogen activator in vivo: a function defined by vessel size and anatomic location. 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Exp Neurol. 2015;267:78–86. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.expneurol.2015.02.032.\nStockinger W, Hengstschläger-Ottnad E, Novak S, Matus A, Hüttinger M, Bauer J, Lassmann H, Schneider WJ, Nimpf J. The low density lipoprotein receptor gene family. J Biol Chem. 1998;273(48):32213–21. https:\u002F\u002Fdoi.org\u002F10.1074\u002Fjbc.273.48.32213.\nStopa EG, Tanis KQ, Miller MC, Nikonova EV, Podtelezhnikov AA, Finney EM, Stone DJ, Camargo LM, Parker L, Verma A, Baird A, Donahue JE, Torabi T, Eliceiri BP, Silverberg GD, Johanson CE. Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis. Fluids Barriers CNS. 2018;15(1):18. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12987-018-0102-9.\nStrazielle N, Ghersi-Egea J-F. Potential pathways for CNS drug delivery across the blood-cerebrospinal fluid barrier. 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Although first recognized in 1870, systematic investigations regarding cerebrospinal fluid (CSF) constituents in this condition are scarce. Routine CSF samples analyzed from 2001 to 2012 at the Laboratory of Clinical Neurochemistry, University of Göttingen, were re-evaluated. Patients, whose CSF contained malignant cells were included in this study. Patients (n = 132, age 59.1 ± 29.1, 58% women) were identified, whose CSF contained malignant cells. The most frequent primary tumor was breast cancer (32.6%), followed by lung cancer (25.0%) and hematologic malignancies (21.2%). The most frequent clinical symptoms were affections of cranial nerves (41.7%), psychiatric abmormalities (32.6%) and radicular lesions of the lower extremities (20.5%). CSF cell counts ranged from 0 to 4692 cells\u002Fμl (median 4 cells\u002Fμl) and were elevated in 50%. The CSF-to-serum albumin ratio was abnormal in 69.4%. It ranged from 1.8 to 330 x 10-3 (median 17.5 x 10-3). Total CSF protein ranged from 166 to 15,840 mg\u002Fl (median 1012 mg\u002Fl). CSF lactate was elevated (>2.4 mmol\u002Fl) in 65.2% [3.6 mmol\u002Fl (1.3\u002F15.6 mmol\u002Fl); median (minimum\u002Fmaximum)]. In 50% of all patients CSF lactate was ≥3.5 mmol\u002Fl. The CSF cell counts correlated significantly with the CSF lactate levels and the CSF protein contents. In 56 of 118 CSF samples (47.5%) ferritin was elevated, and in 25 of 65 carcinoma patients (38.5%) an intrathecal production of carcinoembryonic antigen (CEA) was detected. Granulocytes were found in 52.7% of the CSF samples. The percentages of granulocytes and lymphocytes were higher in samples with an elevated cell count. In approximately 50% of CSF samples with meningeosis neoplastica the CSF cell count is not elevated. Diagnosis may be missed when only CSF samples with elevated cell counts are subjected to cytological analysis. CSF lactate and protein and the CSF-to-serum albumin ratio are frequently increased in meningeosis neoplastica. The differential diagnosis between meningeosis neoplastica and central nervous infections, in particular tuberculous or fungal meningitis, can be difficult.",{"EN":1335},"Cerebrospinal fluid abnormalities in meningeosis neoplastica: a retrospective 12-year analysis",{"VOID":1337},"Eberth CJ. Zur Entwicklung des Epitheliomas (Cholesteatomas) der Pia und der Lunge. Virchow’s Arch. 1870;49:51–63.\nGrossman SA, Krabak MJ. Leptomeningeal carcinomatosis. Cancer Treat Rev. 1999;25:103–19.\nKaplan JG, DeSouza TG, Farkash A, Shafran B, Pack D, Rehman F, Fuks J, Portenoy R. Leptomeningeal metastases: comparison of clinical features and laboratory data of solid tumors, lymphomas and leukemias. J Neurooncol. 1990;9:225–9.\nRosen ST, Aisner J, Makuch RW, Matthews MJ, Ihde DC, Whitacre M, Glatstein EJ, Wiernik PH, Lichter AS, Bunn PA Jr. Carcinomatous leptomeningitis in small cell lung cancer: a clinicopathologic review of the national cancer institute experience. Medicine (Baltimore). 1982;61:45–53.\nhttp:\u002F\u002Fwww.dgn.org\u002Fleitlinien\u002F2979-ll-77-metastasen-und-meningeos-neoplastica Accessed 15 Dec 2016.\nLe Rhun E, Taillibert S, Chamberlain MC. Carcinomatous meningitis: leptomeningeal metastases in solid tumors. Surg Neurol Int. 2013;4(Suppl 4):265–88.\nMorikawa N, Mori T, Kawashima H, Fujiki M, Abe T, Kaku T, Konisi Y, Takeyama M, Hori S. Pharmacokinetics of nimustine, methotrexate, and cytosine arabinoside during cerebrospinal fluid perfusion chemotherapy in patients with disseminated brain tumors. Eur J Clin Pharmacol. 1998;54:415–20.\nReiber H. Eine schnelle und einfache nephelometrische Bestimmungsmethode für Protein im Liquor cerebrospinalis. J Clin Chem Clin Biochem. 1980;18:123–7.\nReiber H, Felgenhauer K. Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chim Acta. 1987;163:319–28.\nWick M Ausgewählte Methoden der Liquordiagnostik und klinichen Neurochemie, 2004. https:\u002F\u002Fwww.uke.de\u002Fextern\u002Fdgln\u002Fpdf\u002FMethodenkatalog.pdf. Accessed 12 Dec 2016\nWildemann B, Oschmann P, Reiber H. Neurologische Labordiagnostik. Stuttgart: Georg Thieme Verlag; 2006.\nWeston CL, Glantz MJ, Connor JR. Detection of cancer cells in the cerebrospinal fluid: current methods and future directions. Fluids Barriers CNS. 2011;8(1):14.\nJacobi C, Reiber H, Felgenhauer K. The clinical relevance of locally produced carcinoembryonic antigen in cerebrospinal fluid. J Neurol. 1986;233:358–61.\nPetereit HF, Sindern E, Wick M. Leitlinien der Liquordiagnostik und Methodenkatalog der Deutschen Gesellschaft für Liquordiagnostik und Klinische Neurochemie. Heidelberg: Springer; 2007.\nLiu J, Jia H, Yang Y, Dai W, Su X, Zhao G. Cerebrospinal fluid cytology and clinical analysis of 34 cases with leptomeningeal carcinomatosis. J Int Med Res. 2009;37:1913–20.\nHornig CR, Busse O, Kaps M. Importance of cerebrospinal fluid lactate determination in neurological diseases. Klin Wochenschr. 1983;61:357–61.\nWellmer A, Prange J, Gerber J, Zysk G, Lange P, Michel U, Eiffert H, Nau R. d- and l-lactate in rabbit and human bacterial meningitis. Scand J Infect Dis. 2001;33:909–13.\nGiulieri S, Chapuis-Taillard C, Jaton K, Cometta A, Chuard C, Hugli O, Du Pasquier R, Bille J, Meylan P, Manuel O, Marchetti O. CSF lactate for accurate diagnosis of community-acquired bacterial meningitis. Eur J Clin Microbiol Infect Dis. 2015;34:2049–55.\nde Almeida SM, Boritza K, Cogo LL, Pessa L, França J, Rota I, Muro M, Ribeiro C, Raboni SM, Vidal LR, Nogueira MB, Ellis R. Quantification of cerebrospinal fluid lactic acid in the differential diagnosis between HIV chronic meningitis and opportunistic meningitis. Clin Chem Lab Med. 2011;49:891–6.\nDjukic M, Schmidt-Samoa C, Lange P, Spreer A, Neubieser K, Eiffert H, Nau R, Schmidt H. Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis. J Neurol. 2012;259:630–6.\nThwaites GE, Chau TT, Stepniewska K, Phu NH, Chuong LV, Sinh DX, White NJ, Parry CM, Farrar JJ. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet. 2002;360:1287–92.\nZou Y, He J, Guo L, Bu H, Liu Y. Prediction of cerebrospinal fluid parameters for tuberculous meningitis. Diagn Cytopathol. 2015;43:701–4.\nSchumacher M, Orszagh M. Imaging techniques in neoplastic meningiosis. J Neurooncol. 1998;38(2–3):111–20.\nReiber H. Flow rate of cerebrospinal fluid (CSF)–a concept common to normal blood–CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci. 1994;122(2):189–203.\nKolodziej MA, Proemmel P, Quint K, Strik HM. Cerebrospinal fluid ferritin—unspecific and unsuitable for disease monitoring. Neurol Neurochir Pol. 2014;48:116–21.\nReiber H. Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry. Arq Neuropsiquiatr. 2016;74:337–50.\nWang P, Piao Y, Zhang X, Li W, Hao X. The concentration of CYFRA 21-1, NSE and CEA in cerebro-spinal fluid can be useful indicators for diagnosis of meningeal carcinomatosis of lung cancer. Cancer Biomark. 2013;13:123–30.",{"VOID":1339},"10.1186\u002Fs12987-017-0057-2","https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12987-017-0057-2",[1342,1366,1386,1401,1423,1436,1449],{"id":1343,"sortIndex":19,"researcher":18,"roles":1344,"affiliations":1345,"properties":1363,"displayName":1365,"givenName":18,"familyName":18},"78b57a81-ae37-494f-a02b-b70debb39c55",[1001],[1346,1354],{"id":1347,"sortIndex":19,"affiliation":1348,"properties":18},"8a53bea7-180e-4007-963c-79b375207b86",{"id":1347,"createTime":18,"updateTime":18,"relativeEntities":1349,"slug":18,"properties":1350,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1353,"statistic":18},[],{"title":1351},{"VI":1352},"Department of Geriatrics, Evangelisches Krankenhaus Göttingen-Weende, Göttingen, 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fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted. A significant disruption to the normal CSF circulation can be life threatening, leading to increased intracranial pressure (ICP), and is implicated in hydrocephalus, idiopathic intracranial hypertension, brain trauma, brain tumours and stroke. Yet, the exact cellular, molecular and physiological mechanisms that contribute to altered hydrodynamic pathways in these diseases are poorly defined or hotly debated. The traditional views and concepts of CSF secretion, flow and drainage have been challenged, also due to recent findings suggesting more complex mechanisms of brain fluid dynamics than previously proposed. This review evaluates and summarises current hypotheses of CSF dynamics and presents evidence for the role of impaired CSF dynamics in elevated ICP, alongside discussion of the proteins that are potentially involved in altered CSF physiology during neurological disease. Undoubtedly CSF secretion, absorption and drainage are important aspects of brain fluid homeostasis in maintaining a stable ICP. Traditionally, pharmacological interventions or CSF drainage have been used to reduce ICP elevation due to over production of CSF. However, these drugs are used only as a temporary solution due to their undesirable side effects. Emerging evidence suggests that pharmacological targeting of aquaporins, transient receptor potential vanilloid type 4 (TRPV4), and the Na+–K+–2Cl− cotransporter (NKCC1) merit further investigation as potential targets in neurological diseases involving impaired brain fluid dynamics and elevated ICP.",{"EN":1539},"Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases",{"VOID":1541},"Johnson I, Teo C. Disorders of CSF hydrodynamics. Child’s Nerv Syst. 2000;16:776–99.\nLeinonen V, Vanninen R, Rauramaa T. Cerebrospinal fluid circulation and hydrocephalus. In: Kovacs GG, Alafuzoff I, editors. 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Brain Res. 1994;633(1–2):305–11.\nPreston D, Simpson S, Halm D, Hochstetler A, Schwerk C, Schroten H, et al. Activation of TRPV4 stimulates transepithelial ion flux in a porcine choroid plexus cell line. Am J Physiol. 2018;315(3):C357–66.\nJie P, Lu Z, Hong Z, Li Y, et al. Activation of transient receptor potential vanilloid 4 is involved in neuronal injury in middle cerebral artery occlusion in mice. Mol Neurobiol. 2016;53(1):8–17.\nDong Q, Li J, Wu Q, Zhao N, Qian C, Ding D, et al. Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia\u002Freperfusion injury in mice. Sci Rep. 2017;7(1):42678.\nTrillo-Contreras JL, Ramírez-Lorca R, Hiraldo-González L, Sánchez-Gomar I, Galán-Cobo A, Suárez-Luna N. Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus. Biochim Biophys Acta Mol Basis Dis. 2018;1864(10):3515–26.\nManley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000;6(2):159–63.\nFrydenlund DS, Bhardwaj A, Otsuka T, Mylonakou MN, Yasumura T, Davidson KGV, et al. Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proc Natl Acad Sci USA. 2006;103(36):13532–6.\nVerkman AS, Anderson MO, Papadopoulos MC. Aquaporins: important but elusive drug targets. Nat Rev Drug Discov. 2014;13(4):259–77.\nFarr GW, Hall CH, Farr SM, Wade R, Detzel JM, Adams AG, et al. Functionalized phenylbenzamides inhibit aquaporin-4 reducing cerebral edema and improving outcome in two models of CNS injury. Neuroscience. 2019;S0306–4522(19):30054–5.\nUldall M, Botfield H, Jansen-Olesen I, Sinclair A, Jensen R. Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats. Neurosci Lett. 2017;645:33–9.\nScotton WJ, Botfield HF, Westgate CS, Mitchell JL, Yiangou A, Uldall MS, et al. Topiramate is more effective than acetazolamide at lowering intracranial pressure. Cephalalgia. 2018;39(2):209–18.\nWall M, McDermott MP, Kieburtz KD, Corbett JJ, Feldon SE, Friedman DI, et al. Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA. 2014;311(16):1641–51.\nJohnson LN, Krohel GB, Madsen RW, March GA. The role of weight loss and acetazolamide in the treatment of idiopathic intracranial hypertension (pseudotumor cerebri). Opthalmology. 1998;105(12):2313–7.\nPiper RJ, Kalyvas AV, Young AM, Hughes MA, Jamjoom AA, Fouyas IP. Interventions for idiopathic intracranial hypertension. Cochrane Database Syst Rev. 2015;8:CD003434.",{"VOID":1543},"10.1186\u002Fs12987-019-0129-6","https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12987-019-0129-6",[1546,1561,1585],{"id":1547,"sortIndex":19,"researcher":18,"roles":1548,"affiliations":1549,"properties":1558,"displayName":1560,"givenName":18,"familyName":18},"428de212-e4e8-4024-83b5-23e0f04c26bb",[1001],[1550],{"id":1551,"sortIndex":19,"affiliation":1552,"properties":18},"c7c01677-d3fb-4075-9e0e-d0a638a9fea0",{"id":1551,"createTime":18,"updateTime":18,"relativeEntities":1553,"slug":18,"properties":1554,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1557,"statistic":18},[],{"title":1555},{"VI":1556},"Brain Barriers Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, Australia",[],{"title":1559},{"VI":1560},"Steven William 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Patabendige",{"url":1544,"publisher":1617,"properties":1670},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1618,"slug":10,"properties":1619,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1622,"manageAffiliations":1639,"indexDatabases":1650,"url":18,"thumbnailPath":18,"statistic":1665,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":1620,"title":1621},{"VOID":13},{"EN":15},[1623,1627,1631,1635],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1624,"label":1625,"description":1626,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1628,"label":1629,"description":1630,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},{"id":34,"createTime":18,"updateTime":18,"relativeEntities":1632,"label":1633,"description":1634,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":37},{},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":1636,"label":1637,"description":1638,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":43},{},[1640,1645],{"id":47,"createTime":18,"updateTime":18,"relativeEntities":1641,"slug":18,"properties":1642,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1644,"statistic":18},[],{"title":1643},{"EN":51},[],{"id":54,"createTime":18,"updateTime":18,"relativeEntities":1646,"slug":18,"properties":1647,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1649,"statistic":18},[],{"title":1648},{"EN":58},[],[1651,1658],{"id":62,"indexDatabase":1652,"url":75,"indexYears":18,"academicFieldIds":1657,"indexDatabaseRanking":18},{"id":64,"createTime":18,"updateTime":18,"relativeEntities":1653,"label":1654,"description":1655,"key":71,"publicationTags":1656,"standard":18},[],{"EN":67,"VI":67},{"EN":69,"VI":70},[73,74],[77],{"id":79,"indexDatabase":1659,"url":90,"indexYears":91,"academicFieldIds":1664,"indexDatabaseRanking":97},{"id":81,"createTime":18,"updateTime":18,"relativeEntities":1660,"label":1661,"description":1662,"key":87,"publicationTags":1663,"standard":18},[],{"EN":84,"VI":84},{"EN":84,"VI":86},[89],[93,94,95,96],{"impactFactor":19,"impactFactorByYear":1666,"i10Index":112,"i10IndexLast5Year":113,"totalPublication":114,"totalPublicationByYear":1667,"totalCitation":128,"totalCitationByYear":1668,"totalCitationPerPublication":141,"totalCitationPerPublicationByYear":1669,"hindexLast5Year":155,"hindex":155},{"2012":100,"2013":101,"2014":102,"2015":103,"2016":104,"2017":105,"2018":106,"2019":107,"2020":108,"2021":109,"2022":110,"2023":111},{"2011":113,"2012":116,"2013":117,"2014":118,"2015":119,"2016":120,"2017":117,"2018":121,"2019":122,"2020":123,"2021":124,"2022":125,"2023":126,"2024":127},{"2011":130,"2012":131,"2013":132,"2014":133,"2015":134,"2016":112,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140},{"2011":143,"2012":144,"2013":145,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":1671,"volume":1673},{"VOID":1672},"1-18",{"VOID":1674},"16","2019-04-10",2019,[97,73],{"id":1679,"createTime":1680,"updateTime":1681,"relativeEntities":1682,"slug":1683,"properties":1684,"entityType":995,"verifyStatus":178,"verifyTime":1681,"verifyNote":1119,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1693,"fullTextUrl":18,"authors":1694,"publicationType":1040,"publisherRelationship":1783,"citationCount":18,"citationInfo":18,"publishDate":1842,"publishYear":1843,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":1844,"openAccess":18,"references":18,"isForceReanalyzing":1103},"04bcb703-9f67-42d0-a735-fc978a46ff3f","2024-01-16T06:28:28.666+00:00","2025-02-03T14:01:55.462+00:00",[],"Pre-and-post-shunting-observations-in-adult-sheep-with-kaolin-induced-hydrocephalus",{"abstract":1685,"title":1687,"references":1689,"doi":1691},{"EN":1686},"The objective of this study was to examine host-shunt interactions in sheep with kaolin-induced hydrocephalus. Forty-two sheep (29–40 kg) were utilized for this study. In 20 animals, various kaolin doses were injected into the cisterna magna including 10 and 50 mg\u002Fkg as well as 2–4 ml of a 25% kaolin suspension. Based on animal health and hydrocephalus development, 3 ml of a 25% kaolin suspension was chosen. In 16 animals, kaolin was administered and 6–8 days later, the animals received a custom made ventriculo-peritoneal shunt. In 8 animals ventricular CSF pressures were measured with a water manometer before kaolin administration and 7–8 days later. The sheep were allowed to survive for up to 9–12 weeks post-kaolin or until clinical status required euthanasia. Brains were assessed for morphological and histological changes. Ventricle\u002Fcerebrum cross sectional area ratios (V\u002FC) were calculated from photographs of the sliced coronal planes immediately anterior to the interventricular foramina. Intraventricular pressures increased from 12.4±1.1 cm H2O to 41.3±3.5 cm H2O following kaolin injection (p \u003C 0.0001, n = 8). In all animals, we observed kaolin on the basal surface of the brain and mild (V\u002FC 0.03-0.10) to moderate (V\u002FC >0.10) ventricular expansion. The animals lost weight between kaolin administration and shunting (33.7±1.2 kg versus 31.0±1.7 kg) with weights after shunting remaining stable up to sacrifice (31.6±2.2 kg). Of 16 shunted animals, 5 did well and were sacrificed 9–12 weeks post-kaolin. In the remainder, the study was terminated at various times due to deteriorating health. Hydrocephalus was associated with thinning of the corpus callosum, but no obvious loss of myelin staining, along with reactive astroglial (glial fibrillary acidic immunoreactive) and microglial (Iba1 immunoreactive) changes in the white matter. Ventricular shunts revealed choroid plexus ingrowth in 5\u002F16, brain tissue ingrowth in 1\u002F16, problems with shunt insertion in 3\u002F16, occlusion by hemorrhagic-inflammatory material in 5\u002F16, or no obstruction in 2\u002F16. Free flowing CSF indicated that the peritoneal catheter was patent. Cerebrospinal fluid shunts in hydrocephalic sheep fail in ways that are reminiscent of human neurosurgical experience suggesting that this model may be helpful in the development of more effective shunt technology.",{"EN":1688},"Pre- and post-shunting observations in adult sheep with kaolin-induced hydrocephalus",{"VOID":1690},"Low D, Drake JM, Seow WT, Ng WH: Management of ventriculo-peritoneal shunts in the paediatric population. Asian J Neurosurg. 2010, 5: 7-14.\nDrake JM, Kestle JR, Milner R, Cinalli G, Boop F, Piatt J, Haines S, Schiff SJ, Cochrane DD, Steinbok P, MacNeil N: Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. Neurosurg. 1998, 43: 294-303. 10.1097\u002F00006123-199808000-00068.\nPiatt JH, Cosgriff M: Monte Carlo simulation of cerebrospinal fluid shunt failure and definition of instability among shunt-treated patients with hydrocephalus. J Neurosurg. 2007, 107: 474-478.\nDrake JM, Kestle JR, Tuli S: CSF shunts 50 years on–past, present and future. Childs Nerv Syst. 2000, 16: 800-804. 10.1007\u002Fs003810000351.\nDel Bigio MR: Biological reactions to cerebrospinal fluid shunt devices: a review of the cellular pathology. Neurosurg. 1998, 42: 319-325. 10.1097\u002F00006123-199802000-00064.\nHarris CA, McAllister JP: 2nd: What we should know about the cellular and tissue response causing catheter obstruction in the treatment of hydrocephalus. Neurosurg. 2012, 70: 1589-1601. 10.1227\u002FNEU.0b013e318244695f.\nBoulton M, Flessner M, Armstrong D, Hay J, Johnston M: Lymphatic drainage of the CNS: effects of lymphatic diversion\u002Fligation on CSF protein transport to plasma. Am J Physiol. 1997, 272: R1613-1619.\nSilver I, Li B, Szalai J, Johnston M: Relationship between intracranial pressure and cervical lymphatic pressure and flow rates in sheep. Am J Physiol. 1999, 277: R1712-1717.\nMollanji R, Bozanovic-Sosic R, Silver I, Li B, Kim C, Midha R, Johnston M: Intracranial pressure accommodation is impaired by blocking pathways leading to extracranial lymphatics. Am J Physiol Regul Integr Comp Physiol. 2001, 280: R1573-1581.\nBoulton M, Flessner M, Armstrong D, Hay J, Johnston M: Determination of volumetric cerebrospinal fluid absorption into extracranial lymphatics in sheep. Am J Physiol. 1998, 274: R88-96.\nCambria S, Gambardella G, Cardia E, Cambria M, Labianca M: Experimental hydrocephalus in the fetus in utero. III. Injection of kaolin into the cisterna magna by transuterine puncture. Chir Patol Sper. 1979, 27: 267-272.\nNakayama DK, Harrison MR, Berger MS, Chinn DH, Halks-Miller M, Edwards MS: Correction of congenital hydrocephalus in utero I. The model: intracisternal kaolin produces hydrocephalus in fetal lambs and rhesus monkeys. J Pediatr Surg. 1983, 18: 331-338. 10.1016\u002FS0022-3468(83)80177-8.\nWong J, Hemley S, Jones N, Cheng S, Bilston L, Stoodley M: Fluid outflow in a large-animal model of posttraumatic syringomyelia. Neurosurg. 2012, 71: 474-480. 10.1227\u002FNEU.0b013e31825927d6.\nCollins P: Experimental obstructive hydrocephalus in the rat: a scanning electron microscopic study. Neuropathol Appl Neurobiol. 1979, 5: 457-468. 10.1111\u002Fj.1365-2990.1979.tb00643.x.\nGranholm L: Induced reversibility of ventricular dilatation in experimental hydrocephalus. Acta Neurol Scand. 1966, 42: 581-588.\nAzzi GM, Canady AI, Ham S, Mitchell JA: Kaolin-induced hydrocephalus in the hamster: temporal sequence of changes in intracranial pressure, ventriculomegaly and whole-brain specific gravity. Acta Neuropathol. 1999, 98: 245-250. 10.1007\u002Fs004010051076.\nHochwald GM, Epstein F, Malhan C, Ransohoff J: The relationship of compensated to decompensated hydrocephalus in the cat. J Neurosurg. 1973, 39: 694-697. 10.3171\u002Fjns.1973.39.6.0694.\nWilson CB, Bertan V: Interruption of the anterior choroidal artery in experimental hydrocephalus. Arch Neurol. 1967, 17: 614-619.\nYamada H, Yokota A, Haratake J, Horie A: Morphological study of experimental syringomyelia with kaolin-induced hydrocephalus in a canine model. J Neurosurg. 1996, 84: 999-1005. 10.3171\u002Fjns.1996.84.6.0999.\nDel Bigio MR: Future directions for therapy of childhood hydrocephalus: a view from the laboratory. Pediatr Neurosurg. 2001, 34: 172-181. 10.1159\u002F000056016.\nSlobodian I, Krassioukov-Enns D, Del Bigio MR: Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats. Cerebrospinal Fluid Res. 2007, 4: 9-10.1186\u002F1743-8454-4-9.\nDel Bigio MR, da Silva MC, Drake JM, Tuor UI: Acute and chronic cerebral white matter damage in neonatal hydrocephalus. Can J Neurol Sci. 1994, 21: 299-305.\nDi Curzio DL, Buist RJ, Del Bigio MR: Reduced subventricular zone proliferation and white matter damage in juvenile ferrets with kaolin-induced hydrocephalus. Exp Neurol. 2013, 248C: 112-128.\nDel Bigio MR: Neuropathological changes caused by hydrocephalus. Acta Neuropathol. 1993, 85: 573-585. 10.1007\u002FBF00334666.\nSekhar LN, Moossy J, Guthkelch AN: Malfunctioning ventriculoperitoneal shunts. Clinical and pathological features. J Neurosurg. 1982, 56: 411-416. 10.3171\u002Fjns.1982.56.3.0411.\nDi Trapani G, Garzetti GG, La Cara A, Pentimalli LC: Congenital hydrocephalus: a new experimental model with histopathological study. Ital J Neurol Sci. 1990, 11: 567-572. 10.1007\u002FBF02337439.\nDi Rocco C, Di Trapani G, Pettorossi VE, Caldarelli M: On the pathology of experimental hydrocephalus induced by artificial increase in endoventricular CSF pulse pressure. Childs Brain. 1979, 5: 81-95.\nDe Keersmaecker B, Vloeberghs M, Ville Y: Fetal hydrocephalus and intrauterine cerebral ventriculoscopy: an animal model. Fetal Diagn Ther. 2005, 20: 445-449. 10.1159\u002F000086829.\nGlick PL, Harrison MR, Halks-Miller M, Adzick NS, Nakayama DK, Anderson JH, Nyland TG, Villa R, Edwards MS: Correction of congenital hydrocephalus in utero II: Efficacy of in utero shunting. J Pediatr Surg. 1984, 19: 870-881. 10.1016\u002FS0022-3468(84)80387-5.\nEdwards MS, Harrison MR, Halks-Miller M, Nakayama DK, Berger MS, Glick PL, Chinn DH: Kaolin-induced congenital hydrocephalus in utero in fetal lambs and rhesus monkeys. J Neurosurg. 1984, 60: 115-122. 10.3171\u002Fjns.1984.60.1.0115.\nCambria S, Gambardella G, Cardia E, Cambria M: Experimental endo-uterine hydrocephalus in foetal sheep and surgical treatment by ventriculo-amniotic shunt. Acta Neurochir (Wien). 1984, 72: 235-240. 10.1007\u002FBF01406873.\nCardoso EJ, Lachat JJ, Lopes LS, Santos AC, Colli BO: Changes caused by hydrocephalus, induced by kaolin, in the corpus callosum of adult dogs. Acta Cir Bras. 2011, 26 (Suppl 2): 8-14.\nJohnston M, Zakharov A, Papaiconomou C, Salmasi G, Armstrong D: Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Res. 2004, 1: 2-10.1186\u002F1743-8454-1-2.\nZakharov A, Papaiconomou C, Djenic J, Midha R, Johnston M: Lymphatic cerebrospinal fluid absorption pathways in neonatal sheep revealed by subarachnoid injection of Microfil. Neuropathol Appl Neurobiol. 2003, 29: 563-573. 10.1046\u002Fj.0305-1846.2003.00508.x.\nEskandari R, Packer M, Burdett EC, McAllister JP: Effect of delayed intermittent ventricular drainage on ventriculomegaly and neurological deficits in experimental neonatal hydrocephalus. Childs Nerv Syst. 2012, 28: 1849-1861. 10.1007\u002Fs00381-012-1848-z.",{"VOID":1692},"10.1186\u002F2045-8118-10-24","https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002F2045-8118-10-24",[1695,1710,1725,1740,1753,1768],{"id":1696,"sortIndex":19,"researcher":18,"roles":1697,"affiliations":1698,"properties":1707,"displayName":1709,"givenName":18,"familyName":18},"4d702058-f877-47f7-943c-104428b0a9a7",[1001],[1699],{"id":1700,"sortIndex":19,"affiliation":1701,"properties":18},"77809088-5bb5-4168-8c45-85243f01e273",{"id":1700,"createTime":18,"updateTime":18,"relativeEntities":1702,"slug":18,"properties":1703,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1706,"statistic":18},[],{"title":1704},{"VI":1705},"Brain Sciences, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada",[],{"title":1708},{"VI":1709},"Miles G Johnston",{"id":1711,"sortIndex":190,"researcher":18,"roles":1712,"affiliations":1713,"properties":1722,"displayName":1724,"givenName":18,"familyName":18},"8b793ed3-fcda-4cc9-81f8-0f677b9d6e97",[1001],[1714],{"id":1715,"sortIndex":19,"affiliation":1716,"properties":18},"ab21a483-0aa2-47e7-b50d-4e4b868067d4",{"id":1715,"createTime":18,"updateTime":18,"relativeEntities":1717,"slug":18,"properties":1718,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1721,"statistic":18},[],{"title":1719},{"VI":1720},"Department of Pathology, University of Manitoba, Winnipeg, Canada",[],{"title":1723},{"VI":1724},"Marc R Del Bigio",{"id":1726,"sortIndex":267,"researcher":18,"roles":1727,"affiliations":1728,"properties":1737,"displayName":1739,"givenName":18,"familyName":18},"ee0e90d4-db2d-4209-b828-ad3cbf60e0d9",[1001],[1729],{"id":1730,"sortIndex":19,"affiliation":1731,"properties":18},"cb5e7e5c-cbff-42aa-85db-cbdc6b4bd450",{"id":1730,"createTime":18,"updateTime":18,"relativeEntities":1732,"slug":18,"properties":1733,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1736,"statistic":18},[],{"title":1734},{"VI":1735},"Department of Neurosurgery, Hospital for Sick Children, Toronto, Canada",[],{"title":1738},{"VI":1739},"James M Drake",{"id":1741,"sortIndex":192,"researcher":18,"roles":1742,"affiliations":1743,"properties":1750,"displayName":1752,"givenName":18,"familyName":18},"bc34d75d-701f-4bdb-a7ea-1d3930d2ec8d",[1001],[1744],{"id":1700,"sortIndex":19,"affiliation":1745,"properties":18},{"id":1700,"createTime":18,"updateTime":18,"relativeEntities":1746,"slug":18,"properties":1747,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1749,"statistic":18},[],{"title":1748},{"VI":1705},[],{"title":1751},{"VI":1752},"Dianna Armstrong",{"id":1754,"sortIndex":195,"researcher":18,"roles":1755,"affiliations":1756,"properties":1765,"displayName":1767,"givenName":18,"familyName":18},"bf66e0eb-c4c0-4d69-83ea-113a76497bf0",[1001],[1757],{"id":1758,"sortIndex":19,"affiliation":1759,"properties":18},"9705e732-dabb-4385-a091-87bb949f2d01",{"id":1758,"createTime":18,"updateTime":18,"relativeEntities":1760,"slug":18,"properties":1761,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1764,"statistic":18},[],{"title":1762},{"EN":1763},"Manitoba Institute of Child Health, Winnipeg, Canada",[],{"title":1766},{"VI":1767},"Domenico L Di Curzio",{"id":1769,"sortIndex":196,"researcher":18,"roles":1770,"affiliations":1771,"properties":1780,"displayName":1782,"givenName":18,"familyName":18},"45e1b2e4-eae4-46f6-afd8-7f44b8c866c0",[1001],[1772],{"id":1773,"sortIndex":19,"affiliation":1774,"properties":18},"13cd3fc9-7983-442b-9942-62e57d4a3b7a",{"id":1773,"createTime":18,"updateTime":18,"relativeEntities":1775,"slug":18,"properties":1776,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1779,"statistic":18},[],{"title":1777},{"VI":1778},"Medtronic Neurosurgery, Goleta, USA",[],{"title":1781},{"VI":1782},"Jeff 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30% of cerebrospinal fluid (CSF) shunt systems for hydrocephalus fail within the first year and 98% of all patients will have shunt failure in their lifetime. Obstruction remains the most common reason for shunt failure. Previous evidence suggests elevated pro-inflammatory cytokines in CSF are associated with worsening clinical outcomes in neuroinflammatory diseases. The aim of this study was to determine whether cytokines and matrix metalloproteinases (MMPs) contribute towards shunt failure in hydrocephalus. Using multiplex ELISA, this study examined shunt failure through the CSF protein concentration profiles of select pro-inflammatory and anti-inflammatory cytokines, as well as select MMPs. Interdependencies such as the past number of previous revisions, length of time implanted, patient age, and obstruction or non-obstruction revision were examined. The pro-inflammatory cytokines were IL-1β, IL-2, IL-5, IL-6, IL-8, IL-12, IL-17, TNF-α, GM-CSF, IFN-γ. The anti-inflammatory cytokines were IL-4 and IL-10, and the MMPs were MMP-2, MMP-3, MMP-7, MMP-9. Protein concentration is reported as pg\u002FmL for each analyte. Patient CSF was obtained at the time of shunt revision operation; all pediatric (\u003C 18), totaling n = 38. IL-10, IL-6, IL-8 and MMP-7 demonstrated significantly increased concentrations in patient CSF for the non-obstructed subgroup. Etiological examination revealed IL-6 was increased in both obstructed and non-obstructed cases for PHH and congenital hydrocephalic patients, while IL-8 was higher only in PHH patients. In terms of number of past revisions, IL-10, IL-6, IL-8, MMP-7 and MMP-9 progressively increased from zero to two past revisions and then remained low for subsequent revisions. This presentation was notably absent in the obstruction subgroup. Shunts implanted for three months or less showed significantly increased concentrations of IL-6, IL-8, and MMP-7 in the obstruction subgroup. Lastly, only patients aged six months or less presented with significantly increased concentration of IL-8 and MMP-7. Non-obstructive cases are reported here to accompany significantly higher CSF cytokine and MMP protein levels compared to obstructive cases for IL-10, IL-6, IL-8, MMP-7 and MMP-9. A closer examination of the definition of obstruction and the role neuroinflammation plays in creating shunt obstruction in hydrocephalic patients is suggested.",{"EN":1855},"Cerebrospinal fluid biomarkers of neuroinflammation in children with hydrocephalus and shunt malfunction",{"VOID":1857},"Rizvi R, Anjum Q. Hydrocephalus in children. J Pak Med Assoc. 2005;55(11):502–7.\nVinchon M, et al. Pediatric hydrocephalus outcomes: a review. Fluids Barriers CNS. 2012. https:\u002F\u002Fdoi.org\u002F10.1186\u002F2045-8118-9-18.\nWright Z, et al. Pediatric hydrocephalus: current state of diagnosis and treatment. Pediatrics Rev. 2016;37:478–90. https:\u002F\u002Fdoi.org\u002F10.1542\u002Fpir.2015-0134).\nLangner S, et al. Diagnosis and Differential Diagnosis of Hydrocephalus in Adults”. “Diagnostik und Differenzialdiagnostik des Hydrozephalus beim Erwachsenen. RoFo: Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 2017;189:728–39. https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-0043-108550.\nEymann R. “Klinische Symptome des Hydrozephalus” [Clinical symptoms of hydrocephalus]. Der Radiologe. 2012;52(9):807–12. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00117-012-2327-y.\nIsaacs AM, et al. Age-specific global epidemiology of hydrocephalus: systematic review, metanalysis and global birth surveillance. PLoS ONE. 2018. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0204926.\nSimon TD, et al. Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths. J Neurosurg. 2008;1:131–7. https:\u002F\u002Fdoi.org\u002F10.3171\u002FPED\u002F2008\u002F1\u002F2\u002F131.\nAmmar A. Hydrocephalus: what do we know? And what do we still not know? Berlin: Springer; 2017.\nDewan MC, et al. Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis. J Neurosurg. 2018. https:\u002F\u002Fdoi.org\u002F10.3171\u002F2017.10.JNS17439.\nWeil AG, et al. Efficacy and safety of endoscopic third ventriculostomy and choroid plexus cauterization for infantile hydrocephalus: a systematic review and meta-analysis. Childs Nerv Syst. 2016;32:2119–31. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00381-016-3236-6.\nGottfried ON, et al. Distal ventriculoperitoneal shunt failure secondary to Clostridium difficile colitis. Acta Neurochir. 2005;147(3):335–8. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00701-004-0444-8.\nDrake JM, et al. CSF shunts 50 years on–past, present and future. Childs Nerv Syst. 2000;16(10–11):800–4. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs003810000351.\nLutz BR, et al. New and improved ways to treat hydrocephalus: pursuit of a smart shunt. Surg Neurol Int. 2013;4(1):S38-50. https:\u002F\u002Fdoi.org\u002F10.4103\u002F2152-7806.109197.\nMcAllister JP, Chovan P. Neonatal hydrocephalus. Mechanisms and consequences. Neurosurg Clin N Am. 1998;9(1):73–93.\nKorinek AM, et al. Morbidity of ventricular cerebrospinal fluid shunt surgery in adults: an 8-year study. Neurosurgery. 2011;68(4):985–94. https:\u002F\u002Fdoi.org\u002F10.1227\u002FNEU.0b013e318208f360.\nPaulsen AH, et al. Pediatric hydrocephalus: 40-year outcomes in 128 hydrocephalic patients treated with shunts during childhood. Assessment of surgical outcome, work participation, and health-related quality of life. J Neurosurg. 2015;16(6):633–41. https:\u002F\u002Fdoi.org\u002F10.3171\u002F2015.5.PEDS14532.\nReddy GK, et al. Long-term outcomes of ventriculoperitoneal shunt surgery in patients with hydrocephalus. World Neurosurg. 2014;81(2):404–10. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.wneu.2013.01.096.\nHanak BW, et al. 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Nat Rev Neurosci. 2001;2(7):502–11. https:\u002F\u002Fdoi.org\u002F10.1038\u002F35081571.\nRempe RG, et al. Matrix metalloproteinases in the brain and blood-brain barrier: versatile breakers and makers. J Cereb Blood Flow Metab. 2016;36(9):1481–507. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0271678X16655551.\nYu F, et al. Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury. J Neurotrauma. 2008;25(3):184–95. https:\u002F\u002Fdoi.org\u002F10.1089\u002Fneu.2007.0438.\nSingh D, et al. Multifaceted role of matrix metalloproteinases (MMPs). Front Mol Biosci. 2015. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmolb.2015.00019.\nMinta K, et al. Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury. Sci Rep. 2020;10(1):18075. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41598-020-75233-z.\nHannocks M-J, et al. The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes. 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Alterations in matrix metalloproteinase-9 levels and tissue inhibitor of matrix metalloproteinases-1 expression in a transforming growth factor-beta transgenic model of hydrocephalus. J Neurosci Res. 2002;69(5):662–8. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjnr.10326.\nOkamoto T, et al. Matrix metalloproteinases in infants with posthemorrhagic hydrocephalus. Early Human Dev. 2008;84(2):137–9. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.earlhumdev.2007.08.006.",{"VOID":1859},"10.1186\u002Fs12987-021-00237-4","2025-01-16T18:53:20.839+00:00","https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12987-021-00237-4",[1863,1878,1893,1906,1919],{"id":1864,"sortIndex":19,"researcher":18,"roles":1865,"affiliations":1866,"properties":1875,"displayName":1877,"givenName":18,"familyName":18},"cc5e445a-82b5-411f-b71c-08961c401e8c",[1001],[1867],{"id":1868,"sortIndex":19,"affiliation":1869,"properties":18},"bdd8a0cc-119f-4426-a094-d6b81dbe94ad",{"id":1868,"createTime":18,"updateTime":18,"relativeEntities":1870,"slug":18,"properties":1871,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1874,"statistic":18},[],{"title":1872},{"VI":1873},"Wayne State University Dept. of Chemical Engineering and Materials Science, Detroit, USA",[],{"title":1876},{"VI":1877},"Carolyn A. Harris",{"id":1879,"sortIndex":190,"researcher":18,"roles":1880,"affiliations":1881,"properties":1890,"displayName":1892,"givenName":18,"familyName":18},"e3e6028e-f2c8-4f02-95db-f8d2ee643c7e",[1001],[1882],{"id":1883,"sortIndex":19,"affiliation":1884,"properties":18},"896cffeb-672d-4223-8743-3540763fa6ee",{"id":1883,"createTime":18,"updateTime":18,"relativeEntities":1885,"slug":18,"properties":1886,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1889,"statistic":18},[],{"title":1887},{"VI":1888},"Department of Neurosurgery, Washington University in St. Louis, St. Louis, USA",[],{"title":1891},{"VI":1892},"Diego M. Morales",{"id":1894,"sortIndex":267,"researcher":18,"roles":1895,"affiliations":1896,"properties":1903,"displayName":1905,"givenName":18,"familyName":18},"f9350e99-55c3-499a-b279-13170b2ae40e",[1001],[1897],{"id":1868,"sortIndex":19,"affiliation":1898,"properties":18},{"id":1868,"createTime":18,"updateTime":18,"relativeEntities":1899,"slug":18,"properties":1900,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1902,"statistic":18},[],{"title":1901},{"VI":1873},[],{"title":1904},{"VI":1905},"Rooshan Arshad",{"id":1907,"sortIndex":192,"researcher":18,"roles":1908,"affiliations":1909,"properties":1916,"displayName":1918,"givenName":18,"familyName":18},"791d5575-e1e6-4be0-a483-5ad4b14aa639",[1001],[1910],{"id":1883,"sortIndex":19,"affiliation":1911,"properties":18},{"id":1883,"createTime":18,"updateTime":18,"relativeEntities":1912,"slug":18,"properties":1913,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1915,"statistic":18},[],{"title":1914},{"VI":1888},[],{"title":1917},{"VI":1918},"James P. McAllister",{"id":1920,"sortIndex":195,"researcher":18,"roles":1921,"affiliations":1922,"properties":1931,"displayName":1933,"givenName":18,"familyName":18},"5a56788f-d9f5-4fba-8a7e-5a69db16c950",[1001],[1923],{"id":1924,"sortIndex":19,"affiliation":1925,"properties":18},"7126aa9b-ac8f-4883-9124-11f91fcb88f5",{"id":1924,"createTime":18,"updateTime":18,"relativeEntities":1926,"slug":18,"properties":1927,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1930,"statistic":18},[],{"title":1928},{"VI":1929},"Division of Pediatric Neurosurgery, and Department of Pediatrics, Department of Neurosurgery, Washington University in St. Louis, St. Louis, USA",[],{"title":1932},{"VI":1933},"David D. Limbrick",{"url":1861,"publisher":1935,"properties":1988},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1936,"slug":10,"properties":1937,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1940,"manageAffiliations":1957,"indexDatabases":1968,"url":18,"thumbnailPath":18,"statistic":1983,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":1938,"title":1939},{"VOID":13},{"EN":15},[1941,1945,1949,1953],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1942,"label":1943,"description":1944,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1946,"label":1947,"description":1948,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},{"id":34,"createTime":18,"updateTime":18,"relativeEntities":1950,"label":1951,"description":1952,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":37},{},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":1954,"label":1955,"description":1956,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":43},{},[1958,1963],{"id":47,"createTime":18,"updateTime":18,"relativeEntities":1959,"slug":18,"properties":1960,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1962,"statistic":18},[],{"title":1961},{"EN":51},[],{"id":54,"createTime":18,"updateTime":18,"relativeEntities":1964,"slug":18,"properties":1965,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1967,"statistic":18},[],{"title":1966},{"EN":58},[],[1969,1976],{"id":62,"indexDatabase":1970,"url":75,"indexYears":18,"academicFieldIds":1975,"indexDatabaseRanking":18},{"id":64,"createTime":18,"updateTime":18,"relativeEntities":1971,"label":1972,"description":1973,"key":71,"publicationTags":1974,"standard":18},[],{"EN":67,"VI":67},{"EN":69,"VI":70},[73,74],[77],{"id":79,"indexDatabase":1977,"url":90,"indexYears":91,"academicFieldIds":1982,"indexDatabaseRanking":97},{"id":81,"createTime":18,"updateTime":18,"relativeEntities":1978,"label":1979,"description":1980,"key":87,"publicationTags":1981,"standard":18},[],{"EN":84,"VI":84},{"EN":84,"VI":86},[89],[93,94,95,96],{"impactFactor":19,"impactFactorByYear":1984,"i10Index":112,"i10IndexLast5Year":113,"totalPublication":114,"totalPublicationByYear":1985,"totalCitation":128,"totalCitationByYear":1986,"totalCitationPerPublication":141,"totalCitationPerPublicationByYear":1987,"hindexLast5Year":155,"hindex":155},{"2012":100,"2013":101,"2014":102,"2015":103,"2016":104,"2017":105,"2018":106,"2019":107,"2020":108,"2021":109,"2022":110,"2023":111},{"2011":113,"2012":116,"2013":117,"2014":118,"2015":119,"2016":120,"2017":117,"2018":121,"2019":122,"2020":123,"2021":124,"2022":125,"2023":126,"2024":127},{"2011":130,"2012":131,"2013":132,"2014":133,"2015":134,"2016":112,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140},{"2011":143,"2012":144,"2013":145,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":1989,"volume":1991},{"VOID":1990},"1-14",{"VOID":1992},"18","2021-01-29",2021,[97,73],{"id":1997,"createTime":1998,"updateTime":1999,"relativeEntities":2000,"slug":2001,"properties":2002,"entityType":995,"verifyStatus":178,"verifyTime":1999,"verifyNote":1119,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":2011,"fullTextUrl":18,"authors":2012,"publicationType":1040,"publisherRelationship":2101,"citationCount":18,"citationInfo":18,"publishDate":2158,"publishYear":1323,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":2159,"openAccess":18,"references":18,"isForceReanalyzing":1103},"05b8c6ec-85ec-4176-81bb-51a922d759fe","2024-02-08T19:55:44.802+00:00","2024-07-18T20:49:06.160+00:00",[],"The-timed-up-and-go-test-in-idiopathic-normal-pressure-hydrocephalus-a-Nationwide-Study-of-1300-patients",{"abstract":2003,"title":2005,"references":2007,"doi":2009},{"EN":2004},"The aim of this study was to describe the outcome measure timed up and go (TUG) in a large, nationwide cohort of patients with idiopathic normal pressure hydrocephalus (iNPH) pre- and post-operatively. Furthermore, to compare the TUG test to the 10-m walk test (10MWT), the iNPH scale, the modified Rankin scale (mRS) and the Mini Mental State Examination (MMSE), which are commonly applied in clinical assessment of iNPH. Patients with iNPH (n = 1300), registered in the Swedish Hydrocephalus Quality Registry (SHQR), were included. All data were retrieved from the SHQR except the 10MWT, which was collected from patient medical records. Clinical scales were examined pre- and 3 months post-operatively. Data were dichotomised by sex, age, and preoperative TUG time. Preoperative TUG values were 19.0 [14.0–26.0] s (median [IQR]) and 23 [18–30] steps. Post-operatively, significant improvements to 14.0 [11.0–20.0] s and 19 [15–25] steps were seen. TUG time and steps were higher in women compared to men (p \u003C 0.001) but there was no sex difference in improvement rate. Worse preoperative TUG and younger age favoured improvement. TUG was highly correlated to the 10MWT, but correlations of post-operative changes were only low to moderate between all scales (r = 0.22–0.61). This study establishes the distribution of TUG in iNPH patients and shows that the test captures important clinical features that improve after surgery independent of sex and in all age groups, confirming the clinical value of the TUG test. TUG performance is associated with performance on the 10MWT pre- and post-operatively. However, the weak correlations in post-operative change to the 10MWT and other established outcome measures indicate an additional value of TUG when assessing the effects of shunt surgery.",{"EN":2006},"The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients",{"VOID":2008},"Hakim S, Adams RD. The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J Neurol Sci. 1965;2(4):307–27.\nAndersson J, Rosell M, Kockum K, Lilja-Lund O, Soderstrom L, Laurell K. Prevalence of idiopathic normal pressure hydrocephalus: a prospective, population-based study. PLoS ONE. 2019;14(5):e0217705.\nMartin-Laez R, Caballero-Arzapalo H, Valle-San Roman N, Lopez-Menendez LA, Arango-Lasprilla JC, Vazquez-Barquero A. Incidence of idiopathic normal-pressure hydrocephalus in Northern Spain. World Neurosurg. 2016;87:298–310.\nToma AK, Papadopoulos MC, Stapleton S, Kitchen ND, Watkins LD. Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus. Acta Neurochir. 2013;155(10):1977–80.\nKubo Y, Kazui H, Yoshida T, Kito Y, Kimura N, Tokunaga H, et al. Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus. Dement Geriatr Cogn Disord. 2008;25(1):37–45.\nStein SC, Langfitt TW. Normal-pressure hydrocephalus. Predicting the results of cerebrospinal fluid shunting. J Neurosurg. 1974;41(4):463–70.\nHellstrom P, Klinge P, Tans J, Wikkelso C. A new scale for assessment of severity and outcome in iNPH. Acta Neurol Scand. 2012;126(4):229–37.\nvan Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19(5):604–7.\nFolstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.\nMalm J, Kristensen B, Karlsson T, Fagerlund M, Elfverson J, Ekstedt J. The predictive value of cerebrospinal fluid dynamic tests in patients with th idiopathic adult hydrocephalus syndrome. Arch Neurol. 1995;52(8):783–9.\nPodsiadlo D, Richardson S. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–8.\nHerman T, Giladi N, Hausdorff JM. Properties of the ‘timed up and go’ test: more than meets the eye. Gerontology. 2011;57(3):203–10.\nViccaro LJ, Perera S, Studenski SA. Is timed up and go better than gait speed in predicting health, function, and falls in older adults? J Am Geriatr Soc. 2011;59(5):887–92.\nBarry E, Galvin R, Keogh C, Horgan F, Fahey T. Is the timed up and go test a useful predictor of risk of falls in community dwelling older adults: a systematic review and meta-analysis. BMC Geriatr. 2014;14:14.\nYamada S, Ishikawa M, Miyajima M, Nakajima M, Atsuchi M, Kimura T, et al. Timed up and go test at tap test and shunt surgery in idiopathic normal pressure hydrocephalus. Neurol Clin Pract. 2017;7(2):98–108.\nYamada S, Aoyagi Y, Yamamoto K, Ishikawa M. Quantitative evaluation of gait disturbance on an instrumented timed up-and-go test. Aging Dis. 2019;10(1):23–36.\nIshikawa M, Yamada S, Yamamoto K, Aoyagi Y. Gait analysis in a component timed-up-and-go test using a smartphone application. J Neurol Sci. 2019;398:45–9.\nAgerskov S, Hellstrom P, Andren K, Kollen L, Wikkelso C, Tullberg M. The phenotype of idiopathic normal pressure hydrocephalus-a single center study of 429 patients. J Neurol Sci. 2018;391:54–60.\nSundstrom N, Lagebrant M, Eklund A, Koskinen LD, Malm J. Subdural hematomas in 1846 patients with shunted idiopathic normal pressure hydrocephalus: treatment and long-term survival. J Neurosurg. 2018;129(3):797–804.\nSundstrom N, Malm J, Laurell K, Lundin F, Kahlon B, Cesarini KG, et al. Incidence and outcome of surgery for adult hydrocephalus patients in Sweden. Br J Neurosurg. 2017;31(1):21–7.\nAndren K, Wikkelso C, Sundstrom N, Agerskov S, Israelsson H, Laurell K, et al. Long-term effects of complications and vascular comorbidity in idiopathic normal pressure hydrocephalus: a quality registry study. J Neurol. 2018;265(1):178–86.\nRelkin N, Marmarou A, Klinge P, Bergsneider M, Black PM. Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005;57(3 Suppl):S4-16 (discussion ii–v).\nShumway-Cook A, Brauer S, Woollacott M. Predicting the probability for falls in community-dwelling older adults using the Timed Up & Go Test. Phys Ther. 2000;80(9):896–903.\nMukaka MM. Statistics corner: a guide to appropriate use of correlation coefficient in medical research. Malawi Med J. 2012;24(3):69–71.\nMirelman A, Weiss A, Buchman AS, Bennett DA, Giladi N, Hausdorff JM. Association between performance on Timed Up and Go subtasks and mild cognitive impairment: further insights into the links between cognitive and motor function. J Am Geriatr Soc. 2014;62(4):673–8.\nMcGough EL, Kelly VE, Logsdon RG, McCurry SM, Cochrane BB, Engel JM, et al. Associations between physical performance and executive function in older adults with mild cognitive impairment: gait speed and the timed “up & go” test. Phys Ther. 2011;91(8):1198–207.\nBohannon RW. Reference values for the timed up and go test: a descriptive meta-analysis. J Geriatr Phys Ther. 2006;29(2):64–8.\nAndren K, Wikkelso C, Hellstrom P, Tullberg M, Jaraj D. Early shunt surgery improves survival in idiopathic normal pressure hydrocephalus. Eur J Neurol. 2021;28(4):1153–9.\nNikaido Y, Urakami H, Akisue T, Okada Y, Katsuta N, Kawami Y, et al. Associations among falls, gait variability, and balance function in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2019;183:105385.\nNikaido Y, Kajimoto Y, Akisue T, Urakami H, Kawami Y, Kuroda K, et al. Dynamic balance measurements can differentiate patients who fall from patients who do not fall in patients with idiopathic normal pressure hydrocephalus. Arch Phys Med Rehabil. 2019;100(8):1458–66.\nNikaido Y, Akisue T, Urakami H, Kajimoto Y, Kuroda K, Kawami Y, et al. Postural control before and after cerebrospinal fluid shunt surgery in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2018;172:46–50.\nSelge C, Schoeberl F, Zwergal A, Nuebling G, Brandt T, Dieterich M, et al. Gait analysis in PSP and NPH: dual-task conditions make the difference. Neurology. 2018;90(12):e1021–8.\nCoelho-Junior HJ, Uchida MC, Goncalves IO, Calvani R, Rodrigues B, Picca A, et al. Age- and gender-related changes in physical function in community-dwelling Brazilian adults aged 50 to 102 years. J Geriatr Phys Ther. 2021;44(2):E123–31.\nIbrahim A, Singh DKA, Shahar S. ‘Timed Up and Go’ test: age, gender and cognitive impairment stratified normative values of older adults. PLoS ONE. 2017;12(10):e0185641.\nReid KF, Doros G, Clark DJ, Patten C, Carabello RJ, Cloutier GJ, et al. Muscle power failure in mobility-limited older adults: preserved single fiber function despite lower whole muscle size, quality and rate of neuromuscular activation. Eur J Appl Physiol. 2012;112(6):2289–301.\nDonoghue OA, Horgan NF, Savva GM, Cronin H, O’Regan C, Kenny RA. Association between timed up-and-go and memory, executive function, and processing speed. J Am Geriatr Soc. 2012;60(9):1681–6.\nLiu Y, Ma W, Li M, Han P, Cai M, Wang F, et al. Relationship between physical performance and mild cognitive impairment in Chinese community-dwelling older adults. Clin Interv Aging. 2021;16:119–27.\nKlinge P, Hellstrom P, Tans J, Wikkelso C. European i NPHMSG. One-year outcome in the European multicentre study on iNPH. Acta Neurol Scand. 2012;126(3):145–53.\nKimura T, Yamada S, Sugimura T, Seki T, Miyano M, Fukuda S, et al. Preoperative predictive factors of short-term outcome in idiopathic normal pressure hydrocephalus. World Neurosurg. 2021;151:e399–406.\nBloem BR, Marinus J, Almeida Q, Dibble L, Nieuwboer A, Post B, et al. Measurement instruments to assess posture, gait, and balance in Parkinson’s disease: critique and recommendations. Mov Disord. 2016;31(9):1342–55.\nDewey DC, Miocinovic S, Bernstein I, Khemani P, Dewey RB 3rd, Querry R, et al. Automated gait and balance parameters diagnose and correlate with severity in Parkinson disease. J Neurol Sci. 2014;345(1–2):131–8.\nHerman T, Weiss A, Brozgol M, Giladi N, Hausdorff JM. Identifying axial and cognitive correlates in patients with Parkinson’s disease motor subtype using the instrumented Timed Up and Go. Exp Brain Res. 2014;232(2):713–21.\nBorm C, Krismer F, Wenning GK, Seppi K, Poewe W, Pellecchia MT, et al. Axial motor clues to identify atypical parkinsonism: a multicentre European cohort study. Parkinsonism Relat Disord. 2018;56:33–40.\nDibilio V, Nicoletti A, Mostile G, Toscano S, Luca A, Raciti L, et al. Dopaminergic and non-dopaminergic gait components assessed by instrumented timed up and go test in Parkinson’s disease. J Neural Transm (Vienna). 2017;124(12):1539–46.\nMendes GAS, de Oliveira MF, Pinto FCG. The timed up and go test as a diagnostic criterion in normal pressure hydrocephalus. World Neurosurg. 2017;105:456–61.",{"VOID":2010},"10.1186\u002Fs12987-021-00298-5","https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12987-021-00298-5",[2013,2028,2043,2058,2073,2086],{"id":2014,"sortIndex":19,"researcher":18,"roles":2015,"affiliations":2016,"properties":2025,"displayName":2027,"givenName":18,"familyName":18},"67e3f839-f336-4df8-aa11-fa239b2721ad",[1001],[2017],{"id":2018,"sortIndex":19,"affiliation":2019,"properties":18},"49a80eee-0625-453c-9dd7-48f2e808225b",{"id":2018,"createTime":18,"updateTime":18,"relativeEntities":2020,"slug":18,"properties":2021,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2024,"statistic":18},[],{"title":2022},{"VI":2023},"Department of Radiation Sciences, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden",[],{"title":2026},{"VI":2027},"Nina Sundström",{"id":2029,"sortIndex":190,"researcher":18,"roles":2030,"affiliations":2031,"properties":2040,"displayName":2042,"givenName":18,"familyName":18},"23359774-2202-4076-b53c-2dae8898fba7",[1001],[2032],{"id":2033,"sortIndex":19,"affiliation":2034,"properties":18},"d0ee84c1-cc38-447a-a657-9aec7d363851",{"id":2033,"createTime":18,"updateTime":18,"relativeEntities":2035,"slug":18,"properties":2036,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2039,"statistic":18},[],{"title":2037},{"VI":2038},"Department of Activity and Health, and Department of Biomedical and Clinical\nSciences, Linköping University, Linköping, Sweden",[],{"title":2041},{"VI":2042},"Johanna Rydja",{"id":2044,"sortIndex":267,"researcher":18,"roles":2045,"affiliations":2046,"properties":2055,"displayName":2057,"givenName":18,"familyName":18},"d523f2f4-fa86-4e74-87f9-86ee6c45c76c",[1001],[2047],{"id":2048,"sortIndex":19,"affiliation":2049,"properties":18},"25070b4f-6ec7-4a1e-aa59-84948be6af61",{"id":2048,"createTime":18,"updateTime":18,"relativeEntities":2050,"slug":18,"properties":2051,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2054,"statistic":18},[],{"title":2052},{"VI":2053},"Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden",[],{"title":2056},{"VI":2057},"Johan Virhammar",{"id":2059,"sortIndex":192,"researcher":18,"roles":2060,"affiliations":2061,"properties":2070,"displayName":2072,"givenName":18,"familyName":18},"556ddf82-8b23-4733-9b58-fb3d48bbb5ef",[1001],[2062],{"id":2063,"sortIndex":19,"affiliation":2064,"properties":18},"b903863e-3e00-42e0-aada-fa3265f7ef48",{"id":2063,"createTime":18,"updateTime":18,"relativeEntities":2065,"slug":18,"properties":2066,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2069,"statistic":18},[],{"title":2067},{"VI":2068},"Department of Neurology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden",[],{"title":2071},{"VI":2072},"Lena Kollén",{"id":2074,"sortIndex":195,"researcher":18,"roles":2075,"affiliations":2076,"properties":2083,"displayName":2085,"givenName":18,"familyName":18},"07224ea2-8902-45a0-b1b8-e13fa017b6c1",[1001],[2077],{"id":2063,"sortIndex":19,"affiliation":2078,"properties":18},{"id":2063,"createTime":18,"updateTime":18,"relativeEntities":2079,"slug":18,"properties":2080,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2082,"statistic":18},[],{"title":2081},{"VI":2068},[],{"title":2084},{"VI":2085},"Fredrik Lundin",{"id":2087,"sortIndex":196,"researcher":18,"roles":2088,"affiliations":2089,"properties":2098,"displayName":2100,"givenName":18,"familyName":18},"48592078-7f7d-4526-8f51-9769082ca9e8",[1001],[2090],{"id":2091,"sortIndex":19,"affiliation":2092,"properties":18},"9b7818db-3dbc-484d-9726-5c414da42334",{"id":2091,"createTime":18,"updateTime":18,"relativeEntities":2093,"slug":18,"properties":2094,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2097,"statistic":18},[],{"title":2095},{"VI":2096},"Hydrocephalus Research Unit, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden",[],{"title":2099},{"VI":2100},"Mats Tullberg",{"url":2011,"publisher":2102,"properties":2155},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2103,"slug":10,"properties":2104,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":2107,"manageAffiliations":2124,"indexDatabases":2135,"url":18,"thumbnailPath":18,"statistic":2150,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":2105,"title":2106},{"VOID":13},{"EN":15},[2108,2112,2116,2120],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":2109,"label":2110,"description":2111,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":2113,"label":2114,"description":2115,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},{"id":34,"createTime":18,"updateTime":18,"relativeEntities":2117,"label":2118,"description":2119,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":37},{},{"id":40,"createTime":18,"updateTime":18,"relativeEntities":2121,"label":2122,"description":2123,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":43},{},[2125,2130],{"id":47,"createTime":18,"updateTime":18,"relativeEntities":2126,"slug":18,"properties":2127,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2129,"statistic":18},[],{"title":2128},{"EN":51},[],{"id":54,"createTime":18,"updateTime":18,"relativeEntities":2131,"slug":18,"properties":2132,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2134,"statistic":18},[],{"title":2133},{"EN":58},[],[2136,2143],{"id":62,"indexDatabase":2137,"url":75,"indexYears":18,"academicFieldIds":2142,"indexDatabaseRanking":18},{"id":64,"createTime":18,"updateTime":18,"relativeEntities":2138,"label":2139,"description":2140,"key":71,"publicationTags":2141,"standard":18},[],{"EN":67,"VI":67},{"EN":69,"VI":70},[73,74],[77],{"id":79,"indexDatabase":2144,"url":90,"indexYears":91,"academicFieldIds":2149,"indexDatabaseRanking":97},{"id":81,"createTime":18,"updateTime":18,"relativeEntities":2145,"label":2146,"description":2147,"key":87,"publicationTags":2148,"standard":18},[],{"EN":84,"VI":84},{"EN":84,"VI":86},[89],[93,94,95,96],{"impactFactor":19,"impactFactorByYear":2151,"i10Index":112,"i10IndexLast5Year":113,"totalPublication":114,"totalPublicationByYear":2152,"totalCitation":128,"totalCitationByYear":2153,"totalCitationPerPublication":141,"totalCitationPerPublicationByYear":2154,"hindexLast5Year":155,"hindex":155},{"2012":100,"2013":101,"2014":102,"2015":103,"2016":104,"2017":105,"2018":106,"2019":107,"2020":108,"2021":109,"2022":110,"2023":111},{"2011":113,"2012":116,"2013":117,"2014":118,"2015":119,"2016":120,"2017":117,"2018":121,"2019":122,"2020":123,"2021":124,"2022":125,"2023":126,"2024":127},{"2011":130,"2012":131,"2013":132,"2014":133,"2015":134,"2016":112,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140},{"2011":143,"2012":144,"2013":145,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":2156,"volume":2157},{"VOID":1839},{"VOID":1321},"2022-01-10",[97,73],{"id":2161,"createTime":2162,"updateTime":2163,"relativeEntities":2164,"slug":2165,"properties":2166,"entityType":995,"verifyStatus":178,"verifyTime":2163,"verifyNote":1119,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":2175,"fullTextUrl":18,"authors":2176,"publicationType":1040,"publisherRelationship":2338,"citationCount":18,"citationInfo":18,"publishDate":2395,"publishYear":1323,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":2396,"openAccess":18,"references":18,"isForceReanalyzing":1103},"05ca36bc-c8ba-4948-b3f1-9935f3b3f0b5","2023-12-14T01:06:10.107+00:00","2025-02-24T15:44:09.989+00:00",[],"Glioblastoma-microenvironment-contains-multiple-hormonal-and-non-hormonal-growth-stimulating-factors",{"abstract":2167,"title":2169,"references":2171,"doi":2173},{"EN":2168},"The growth of malignant tumors is influenced by their microenvironment. Glioblastoma, an aggressive primary brain tumor, may have cysts containing fluid that represents the tumor microenvironment. The aim of this study was to investigate whether the cyst fluid of cystic glioblastomas contains growth-stimulating factors. Identification of such growth factors may pave the way for the development of targeted anti-glioblastoma therapies. We performed hormone analysis of cyst fluid from 25 cystic glioblastomas and proteomics analysis of cyst fluid from another 12 cystic glioblastomas. Glioblastoma cyst fluid contained hormones within wide concentration ranges: Insulin-like growth factor 1 (0–13.7 nmol\u002FL), insulin (1.4–133 pmol\u002FL), erythropoietin (4.7–402 IU\u002FL), growth hormone (0–0.93 µg\u002FL), testosterone (0.2–10.1 nmol\u002FL), estradiol (0–1.0 nmol\u002FL), triiodothyronine (1.0–11.5). Tumor volume correlated with cyst fluid concentrations of growth hormone and testosterone. Survival correlated inversely with cyst fluid concentration of erythropoietin. Several hormones were present at concentrations that have been shown to stimulate glioblastoma growth in vitro. Concentrations of erythropoietin and estradiol (in men) were higher in cyst fluid than in serum, suggesting formation by tumor or brain tissue. Quantitatively, glioblastoma cyst fluid was dominated by serum proteins, illustrating blood–brain barrier leakage. Proteomics identified several proteins that stimulate tumor cell proliferation and invasiveness, others that inhibit apoptosis or mediate adaption to hypoxia and some that induce neovascularization or blood–brain barrier leakage. The microenvironment of glioblastomas is rich in growth-stimulating factors that may originate from the circulation, the tumor, or the brain. The wide variation in cyst fluid hormone concentrations may differentially influence tumor growth.",{"EN":2170},"Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors",{"VOID":2172},"Ali A, Creevey L, Hao Y, McCartan D, O’Gaora P, Hill A, Young L, McIlroy M. Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer. Breast Cancer Res. 2015;17(1):123. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13058-015-0636-6.\nCenciarini M, Valentino M, Belia S, Sforna L, Rosa P, Ronchetti S, D’Adamo MC, Pessia M. Dexamethasone in glioblastoma multiforme therapy: mechanisms and controversies. Front Mol Neurosci. 2019;12:65. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffnmol.2019.00065.\nCox J, Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. 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HYOU1\u002FOrp150 expression in breast cancer. Med Sci Monit. 2007;13(11):231–9.\nStokum JA, Gerzanich V, Simard JM. Molecular pathophysiology of cerebral edema. J Cereb Blood Flow Metab. 2016;36(3):513–38. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0271678X15617172.\nTakano S, Yoshii Y, Kondo S, Suzuki H, Maruno T, Shirai S, Nose T. Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res. 1996;56(9):2185–90.\nVan Raalte DH, Nofrate V, Bunck MC, van Iersel T, Elassaiss Schaap J, Nässander UK, Heine RJ, Mari A, Dokter WH, Diamant M. Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men. Eur J Endocrinol. 2010;162(4):729–35. https:\u002F\u002Fdoi.org\u002F10.1530\u002FEJE-09-1034.\nWaerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell. 2006;10(3):227–39. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ccr.2006.07.020.\nWang X, Abraham S, McKenzie J, Jeffs N, Swire M, Tripathi VB, Luhmann U, Lange C, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J. LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Nature. 2013;499(7458):306–11. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnature12345.\nWang XQ, Tao BB, Li B, Wang XH, Zhang WC, Wan L, Hua XM, Li ST. Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma. Oncotarget. 2016;7(3):2354–66. https:\u002F\u002Fdoi.org\u002F10.18632\u002Foncotarget.6221.\nWestphal M, Nausch H, Herrmann HD. Cyst fluids of malignant human brain tumors contain substances that stimulate the growth of cultured human gliomas of various histological type. Neurosurgery. 1989;25(2):196–201. https:\u002F\u002Fdoi.org\u002F10.1097\u002F00006123-198908000-00007.\nWunderer G, Walter I, Eschenbacher B, Lang M, Kellermann J, Kindermann G. Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions. Biol Chem Hoppe-Seyler. 1990;371(10):977–81. https:\u002F\u002Fdoi.org\u002F10.1515\u002Fbchm3.1990.371.2.977.",{"VOID":2174},"10.1186\u002Fs12987-022-00333-z","https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12987-022-00333-z",[2177,2192,2207,2222,2246,2259,2283,2296,2309],{"id":2178,"sortIndex":19,"researcher":18,"roles":2179,"affiliations":2180,"properties":2189,"displayName":2191,"givenName":18,"familyName":18},"bc76253e-2ffb-4d56-9b3b-1292cb646759",[1001],[2181],{"id":2182,"sortIndex":19,"affiliation":2183,"properties":18},"178166e4-4910-4f42-8027-0ee7df4606c2",{"id":2182,"createTime":18,"updateTime":18,"relativeEntities":2184,"slug":18,"properties":2185,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2188,"statistic":18},[],{"title":2186},{"VI":2187},"Department of Neurosurgery, Oslo University Hospital, Oslo, 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clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging data it remains unknown whether the nasal mucosa is a CSF drainage site in humans. Here, we used dynamic PET with [1-11C]-Butanol, a highly permeable radiotracer with no appreciable brain binding, to test the hypothesis that tracer drainage from the nasal pathway reflects CSF drainage from brain. As a test of the hypothesis, we examined whether brain and nasal fluid drainage times were correlated and affected by brain amyloid. 24 cognitively normal subjects (≥ 65 years) were dynamically PET imaged for 60 min. using [1-11C]-Butanol. Imaging with either [11C]-PiB or [18F]-FBB identified 8 amyloid PET positive (Aβ+) and 16 Aβ- subjects. MRI-determined regions of interest (ROI) included: the carotid artery, the lateral orbitofrontal (LOF) brain, the cribriform plate, and an All-turbinate region comprised of the superior, middle, and inferior turbinates. The bilateral temporalis muscle and jugular veins served as control regions. Regional time-activity were used to model tracer influx, egress, and AUC. LOF and All-turbinate 60 min AUC were positively associated, thus suggesting a connection between the brain and the nose. Further, the Aβ+ subgroup demonstrated impaired tracer kinetics, marked by reduced tracer influx and slower egress. The data show that tracer kinetics for brain and nasal turbinates are related to each other and both reflect the amyloid status of the brain. As such, these data add to evidence that the nasal pathway is a potential CSF drainage site in humans. These data warrant further investigation of brain and nasal contributions to protein clearance in neurodegenerative disease.",{"EN":2407},"[1-11C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects",{"EN":2409},"",{"VOID":2411},"de Leon MJ, Li Y, Okamura N, et al. Cerebrospinal fluid clearance in Alzheimer Disease measured with dynamic PET. J Nucl Med Sep. 2017;58(9):1471–6. https:\u002F\u002Fdoi.org\u002F10.2967\u002Fjnumed.116.187211.\nMehta NH, Suss RA, Dyke JP, et al. Quantifying cerebrospinal fluid dynamics: a review of human neuroimaging contributions to CSF physiology and neurodegenerative disease. Neurobiol Dis Aug. 2022;170:105776. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.nbd.2022.105776.\nEide PK, Pripp AH, Berge B, Hrubos-Strøm H, Ringstad G, Valnes LM. Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality. J Cereb Blood Flow Metab Sep. 2022;42(9):1676–92. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0271678x221090747.\nLi Y, Rusinek H, Butler T, et al. Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease. Fluids Barriers CNS Mar. 2022;14(1):21. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12987-022-00318-y.\nPedersen TJ, Keil SA, Han W, Wang MX, Iliff JJ. The effect of aquaporin-4 mis-localization on Aβ deposition in mice. Neurobiol Dis Jun 1. 2023;181:106100. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.nbd.2023.106100.\nIliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med Aug. 2012;15(147):147ra111. https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscitranslmed.3003748.\nIliff JJ, Chen MJ, Plog BA et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. Dec 3. 2014;34(49):16180-93. https:\u002F\u002Fdoi.org\u002F10.1523\u002Fjneurosci.3020-14.2014.\nIshida K, Yamada K, Nishiyama R, et al. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. J Exp Med Mar. 2022;7(3). https:\u002F\u002Fdoi.org\u002F10.1084\u002Fjem.20211275.\nSelkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med Jun. 2016;8(6):595–608. https:\u002F\u002Fdoi.org\u002F10.15252\u002Femmm.201606210.\nMaccioni RB, Farías G, Morales I, Navarrete L. The revitalized tau hypothesis on Alzheimer’s disease. Arch Med Res Apr. 2010;41(3):226–31. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.arcmed.2010.03.007.\nIqbal K, Liu F, Gong CX, Grundke-Iqbal I. Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res Dec. 2010;7(8):656–64. https:\u002F\u002Fdoi.org\u002F10.2174\u002F156720510793611592.\nTarasoff-Conway JM, Carare RO, Osorio RS, et al. Clearance systems in the brain–implications for Alzheimer diseaser. Nat Rev Neurol Apr. 2016;12(4):248. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnrneurol.2016.36.\nMacAulay N, Keep RF, Zeuthen T. 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