[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_d597a8ac-a933-43b9-8055-3561ca32ac65":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:d597a8ac-a933-43b9-8055-3561ca32ac65,\"}":94},{"code":4,"data":5,"meta":18},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":20,"manageAffiliations":21,"indexDatabases":22,"url":18,"thumbnailPath":18,"statistic":40,"gsStatistic":18,"type":18,"analyzePriority":18},"d597a8ac-a933-43b9-8055-3561ca32ac65","2024-04-22T00:34:59.333+00:00","2025-11-21T10:07:04.885+00:00",[],"Springer-Science-and-Business-Media-LLC",{"eissn":12,"title":14},{"VOID":13},"1752-153X",{"EN":15},"Springer Science and Business Media LLC","PUBLISHER","PENDING",null,0,[],[],[23],{"id":24,"indexDatabase":25,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},"60567b40-4265-40b7-bf39-70fec215566b",{"id":26,"createTime":27,"updateTime":28,"relativeEntities":29,"label":30,"description":32,"key":34,"publicationTags":35,"standard":18},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":31,"VI":31},"Scopus - Elsevier",{"EN":31,"VI":33},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[36],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F6400153159","2007-2018","SCOPUS__Q3",{"impactFactor":19,"impactFactorByYear":41,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":52,"totalCitation":65,"totalCitationByYear":66,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":80,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},0.47,0.49,0.61,0.8,0.74,0.39,0.55,0.93,105,830,{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},24,63,86,17,57,119,117,52,50,54,92,99,4478,{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},16,40,22,85,382,735,1048,737,328,67,457,561,5.4,{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},0.67,0.63,0.26,5,6.7,6.18,8.96,14.17,6.56,1.24,4.97,5.67,37,{"meta":95,"data":97},{"total":96},"836",[98,265,476,627,744,996,1304,1648,1729,1842],{"id":99,"createTime":100,"updateTime":101,"relativeEntities":102,"slug":103,"properties":104,"entityType":113,"verifyStatus":114,"verifyTime":101,"verifyNote":115,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":116,"fullTextUrl":18,"authors":117,"publicationType":236,"publisherRelationship":237,"citationCount":18,"citationInfo":18,"publishDate":262,"publishYear":263,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":264},"b14df10c-9c34-4a05-8294-da96fb00af03","2023-12-28T18:34:04.346+00:00","2024-10-18T23:57:31.911+00:00",[],"Discovery-and-SAR-exploration-of-N-aryl-N-3-aryl-1-2-4-oxadiazol-5-yl-amines-as-potential-therapeutic-agents-for-prostate-cancer",{"references":105,"abstract":107,"title":109,"doi":111},{"VOID":106},"Parkin DM: International variation. Oncogene. 2004, 38: 6329-6340. 10.1038\u002Fsj.onc.1207726.\nJemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ: Cancer Statistics, 2008. Cancer J Clin. 2008, 58: 71-96. 10.3322\u002FCA.2007.0010.\nMoon C, Park JC, Chae YK, Yun JH, Kim S: Current status of experimental therapeutics for prostate cancer. Cancer Lett. 2008, 266: 116-134. 10.1016\u002Fj.canlet.2008.02.065.\nChen FL, Armstrong AJ, George DJ: Cell Signaling Modifiers in Prostate Cancer. Cancer J. 2008, 14: 40-45. 10.1097\u002FPPO.0b013e318161d40f.\nKrasavin M, Karapetian R, Konstantinov I, Gezentsvey Y, Bukhryakov K, Godovykh E, Soldatkina E, Lavrovsky Y, Sosnov A, Gakh AA: Discovery and Potency Optimization of 2-Amino-5-arylmethyl-1,3-thiazole Derivatives as Potential Therapeutic Agents for Prostate Cancer. Arch Pharm Chem Life Sci. 2009, 342: 420-427. 10.1002\u002Fardp.200800201.\nAlimirah F, Chen J, Basrawala Z, Xin H, Choubey D: DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation. FEBS Lett. 2006, 580: 2294-2300. 10.1016\u002Fj.febslet.2006.03.041.\nWalters WP, Ajay , Murcko MA: Recognizing molecules with drug-like properties. Curr Opin Chem Biol. 1999, 3: 384-387. 10.1016\u002FS1367-5931(99)80058-1.\nIspikoudi M, Litinas KE, Fylaktakidou KC: A convenient synthesis of 5-amino-substituted 1,2,4-oxadiazole derivatives via reactions of amidoximes with carbodiimides. Heterocycles. 2008, 75: 1321-1328. 10.3987\u002FCOM-08-11340.",{"EN":108},"A new chemical series of antiproliferative compounds was identified via high-throughput screening on DU-145 human prostate carcinoma cell line (hit compound potency - 5.7 μM). Exploration of the two peripheral diversity vectors of the hit molecule in a hit-targeted library and testing of the resulting compounds led to SAR generalizations and identification of the 'best' pharmacophoric moieties. The latter were merged in a single compound that exhibited a 200-fold better potency than the original hit compound. Specific cancer cell cytotoxicity was confirmed for the most potent compounds.",{"EN":110},"Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer",{"VOID":112},"10.1186\u002F1752-153X-4-4","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-153X-4-4",[118,136,152,167,180,192,205,223],{"id":119,"sortIndex":120,"researcher":18,"roles":121,"affiliations":123,"properties":133},"e46ab6fd-5961-421b-b373-36cfacb31032",2,[122],"AUTHOR",[124],{"id":18,"sortIndex":19,"affiliation":125,"properties":18},{"id":126,"createTime":127,"updateTime":127,"relativeEntities":128,"slug":18,"properties":129,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"260f7f4d-5414-4ec9-aa0d-cc012a9c3019","2023-12-28T18:34:04.376+00:00",[],{"title":130},{"VI":131},"Innovation Department, Chemical Diversity Research Institute, Khimki, Moscow Reg, Russia","AFFILIATION",{"title":134},{"VI":135},"Andrey V Sosnov",{"id":137,"sortIndex":138,"researcher":18,"roles":139,"affiliations":140,"properties":149},"b1d67a45-f968-4307-bde8-12a0c3d80bf0",1,[122],[141],{"id":18,"sortIndex":19,"affiliation":142,"properties":18},{"id":143,"createTime":144,"updateTime":144,"relativeEntities":145,"slug":18,"properties":146,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"bb635a71-f691-481d-9639-5d25e3e19cd0","2023-12-28T18:34:04.358+00:00",[],{"title":147},{"VI":148},"Department of Medicinal Chemistry, Chemical Diversity Research Institute, Khimki, Moscow Reg, Russia",{"title":150},{"VI":151},"Konstantin A Rufanov",{"id":153,"sortIndex":84,"researcher":18,"roles":154,"affiliations":155,"properties":164},"bc3b6bae-ddf4-4f96-a997-31cb759b12c0",[122],[156],{"id":18,"sortIndex":19,"affiliation":157,"properties":18},{"id":158,"createTime":159,"updateTime":159,"relativeEntities":160,"slug":18,"properties":161,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"7666eecc-aabd-4f25-9160-657ee3dd8865","2023-12-28T18:34:04.408+00:00",[],{"title":162},{"VI":163},"Department of Lead Discovery, Chemical Diversity Research Institute, Khimki, Moscow Reg, Russia",{"title":165},{"VI":166},"Olga Soldatkina",{"id":168,"sortIndex":169,"researcher":18,"roles":170,"affiliations":171,"properties":177},"18794336-6d2d-49e7-afae-50975e2678d9",6,[122],[172],{"id":18,"sortIndex":19,"affiliation":173,"properties":18},{"id":158,"createTime":159,"updateTime":159,"relativeEntities":174,"slug":18,"properties":175,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":176},{"VI":163},{"title":178},{"VI":179},"Yan Lavrovsky",{"id":181,"sortIndex":19,"researcher":18,"roles":182,"affiliations":183,"properties":189},"d884f865-9cfb-4632-b2d7-7745e07636fe",[122],[184],{"id":18,"sortIndex":19,"affiliation":185,"properties":18},{"id":143,"createTime":144,"updateTime":144,"relativeEntities":186,"slug":18,"properties":187,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":188},{"VI":148},{"title":190},{"VI":191},"Mikhail Krasavin",{"id":193,"sortIndex":194,"researcher":18,"roles":195,"affiliations":196,"properties":202},"20c1295e-ece4-448a-b749-5ae6924f0733",3,[122],[197],{"id":18,"sortIndex":19,"affiliation":198,"properties":18},{"id":158,"createTime":159,"updateTime":159,"relativeEntities":199,"slug":18,"properties":200,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":201},{"VI":163},{"title":203},{"VI":204},"Ruben Karapetian",{"id":206,"sortIndex":207,"researcher":18,"roles":208,"affiliations":209,"properties":220},"faba252a-684c-4dc1-8e07-deef959b688d",7,[122],[210],{"id":18,"sortIndex":19,"affiliation":211,"properties":18},{"id":212,"createTime":213,"updateTime":214,"relativeEntities":215,"slug":216,"properties":217,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"16692375-5761-4c34-b575-bd0070dc85f5","2024-04-17T12:42:19.525+00:00","2025-01-23T15:47:00.875+00:00",[],"Oak-Ridge-National-Laboratory-Oak-Ridge-USA",{"title":218},{"EN":219},"Oak Ridge National, Laboratory, Oak Ridge, USA",{"title":221},{"VI":222},"Andrei A Gakh",{"id":224,"sortIndex":225,"researcher":18,"roles":226,"affiliations":227,"properties":233},"968ce38a-9b28-496f-b41b-a72158665bd0",4,[122],[228],{"id":18,"sortIndex":19,"affiliation":229,"properties":18},{"id":158,"createTime":159,"updateTime":159,"relativeEntities":230,"slug":18,"properties":231,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":232},{"VI":163},{"title":234},{"VI":235},"Elena Godovykh","ARTICLE",{"url":116,"publisher":238,"properties":257},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":239,"slug":10,"properties":240,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":243,"manageAffiliations":244,"indexDatabases":245,"url":18,"thumbnailPath":18,"statistic":252,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":241,"title":242},{"VOID":13},{"EN":15},[],[],[246],{"id":24,"indexDatabase":247,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":248,"label":249,"description":250,"key":34,"publicationTags":251,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":253,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":254,"totalCitation":65,"totalCitationByYear":255,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":256,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":258,"pages":260},{"VOID":259},"4",{"VOID":261},"1-5","2010-03-09",2010,false,{"id":266,"createTime":267,"updateTime":267,"relativeEntities":268,"slug":269,"properties":270,"entityType":113,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":286,"translateLanguages":18,"viewCount":19,"primaryUrl":288,"fullTextUrl":18,"authors":289,"publicationType":236,"publisherRelationship":371,"citationCount":56,"citationInfo":396,"publishDate":398,"publishYear":399,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":400,"isForceReanalyzing":264},"719b1d36-0bc6-4419-bcec-4ccd97d3176f","2024-04-17T23:56:27.597+00:00",[],"Multi-analyte-approach-for-determining-the-extraction-of-tobacco-constituents-from-pouched-snus-by-consumers-during-use",{"mag":271,"keywords":273,"pmc":274,"openalex":276,"abstract":278,"title":280,"pm":282,"doi":284},{"VOID":272},"2151114539",{},{"VOID":275},"3618139",{"VOID":277},"W2151114539",{"EN":279},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Snus is a smokeless oral tobacco product with a significant history of use in Sweden, where it is regulated under food legislation. Users place a small porous sachet or a pinch of loose snus between the upper jaw and cheek for approximately one hour, leading to partial intake of tobacco constituents. To understand user exposure to tobacco, a multi-analyte approach based on the extraction of pouches by methanol, ethanol and water was validated and applied to the measurement of various constituents, including nicotine, four tobacco-specific nitrosamines (TSNAs), propylene glycol, water, ammonium, nitrate, sodium, chloride, linalool, citronellol, linalyl acetate and geraniol, extracted from snus pouches during use by human consumers.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>After validation against established single-analyte methods, the multi-analyte approach was used to determine constituent levels in snus pouches before and after one hour of use. Although the concentrations in the snus pouches varied from nanogram (e.g. TSNAs) to milligram (e.g. nicotine, sodium and propylene glycol) quantities (25.1 ng to 35.3 mg per 1 g pouch), the mean percentage extracted varied only from 19.2% for linalyl acetate to 37.8% for the TSNA 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) among all constituents analyzed. The TSNAs, some of which are known carcinogens, showed the highest percentage extraction (range 34.6%–37.8%). Measurement variability was low for all analytes, ranging from 2.4% (total TSNAs, NAT) to 9.5% (geraniol). By contrast, inter-subject variability ranged from 6.7% (NAB) to 52.2% (linalyl acetate), and was greater than 20% for eight of the constituents analyzed. Intra-subject variability ranged from 3.4% (citronellol) to 29.7% (geraniol).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n            \u003Cjats:p>Generally, less than a third of each constituent tested was extracted during one hour of snus use, independent of constituent concentration. The variable nature of in-use extraction was shown to be driven by inter-subject variability. The results provide insight into possible mechanisms controlling constituent extraction in the mouth during snus use, and provide reference data for the development of in-vitro laboratory systems for estimating extraction of tobacco constituents from snus.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":281},"Multi-analyte approach for determining the extraction of tobacco constituents from pouched snus by consumers during use",{"VOID":283},"23548061",{"VOID":285},"10.1186\u002F1752-153x-7-55",[287],"EN","https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-153X-7-55",[290,309,324,339,354],{"id":291,"sortIndex":194,"researcher":18,"roles":292,"affiliations":293,"properties":304},"93b72e45-eb44-472c-84b3-c19886fd76cc",[],[294],{"id":295,"sortIndex":19,"affiliation":296,"properties":18},"2638e68e-7ad0-429b-a57f-70532950ed2c",{"id":297,"createTime":298,"updateTime":298,"relativeEntities":299,"slug":300,"properties":301,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"b87ae2d4-6f7f-487d-8b80-57b2ede03de7","2024-04-17T23:56:27.624+00:00",[],"Group-R-D-British-American-Tobacco-Investments-Ltd-Southampton-SO15-8TL-United-Kingdom",{"title":302},{"EN":303},"Group R&D, British American Tobacco (Investments) Ltd., Southampton, SO15 8TL, United Kingdom",{"openalex":305,"title":307},{"VOID":306},"A5024421007",{"EN":308},"Nicola Peters",{"id":310,"sortIndex":19,"researcher":18,"roles":311,"affiliations":312,"properties":319},"371b5871-aa91-4b5f-bbc9-0ed298f8ae3e",[],[313],{"id":314,"sortIndex":19,"affiliation":315,"properties":18},"90f14b1c-a762-4db5-a36b-7aa047fb994e",{"id":297,"createTime":298,"updateTime":298,"relativeEntities":316,"slug":300,"properties":317,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":318},{"EN":303},{"openalex":320,"title":322},{"VOID":321},"A5081351904",{"EN":323},"Helena Digard",{"id":325,"sortIndex":225,"researcher":18,"roles":326,"affiliations":327,"properties":334},"3f143355-161b-4f3d-85c4-17efadab936d",[],[328],{"id":329,"sortIndex":19,"affiliation":330,"properties":18},"97d05f82-1262-425f-a44c-299334c38dd8",{"id":297,"createTime":298,"updateTime":298,"relativeEntities":331,"slug":300,"properties":332,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":333},{"EN":303},{"openalex":335,"title":337},{"VOID":336},"A5076582362",{"EN":338},"Kevin McAdam",{"id":340,"sortIndex":120,"researcher":18,"roles":341,"affiliations":342,"properties":349},"0d501e7d-5b08-4e29-94b5-ad2d97495435",[],[343],{"id":344,"sortIndex":19,"affiliation":345,"properties":18},"b1650eb0-fa41-4bdc-b842-68a261db74f1",{"id":297,"createTime":298,"updateTime":298,"relativeEntities":346,"slug":300,"properties":347,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":348},{"EN":303},{"openalex":350,"title":352},{"VOID":351},"A5025333462",{"EN":353},"Graham Errington",{"id":355,"sortIndex":138,"researcher":18,"roles":356,"affiliations":357,"properties":364},"c3809eac-faf9-4962-b6f0-25b5b5d75d27",[],[358],{"id":359,"sortIndex":19,"affiliation":360,"properties":18},"6558c859-f794-449b-97c4-a56f4dcd668c",{"id":297,"createTime":298,"updateTime":298,"relativeEntities":361,"slug":300,"properties":362,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":363},{"EN":303},{"openalex":365,"orcid":367,"title":369},{"VOID":366},"A5086522066",{"VOID":368},"https:\u002F\u002Forcid.org\u002F0000-0002-7215-1225",{"EN":370},"Nathan Gale",{"url":18,"publisher":372,"properties":391},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":373,"slug":10,"properties":374,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":377,"manageAffiliations":378,"indexDatabases":379,"url":18,"thumbnailPath":18,"statistic":386,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":375,"title":376},{"VOID":13},{"EN":15},[],[],[380],{"id":24,"indexDatabase":381,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":382,"label":383,"description":384,"key":34,"publicationTags":385,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":387,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":388,"totalCitation":65,"totalCitationByYear":389,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":390,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":392,"issue":394},{"VOID":393},"7",{"VOID":395},"1",{"total":56,"publishYear":18,"statisticByYear":397},{"2015":194,"2016":194,"2017":120,"2018":120,"2020":120,"2021":194,"2022":138,"2023":138},"2013-12-01",2013,[401,404,407,410,413,416,419,423,427,431,435,439,443,447,450,454,457,460,463,467,470,473],{"id":18,"text":402,"url":18,"identifiers":403},"Who, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans: Smokeless tobacco and some tobacco-specific N-nitrosamines. IARC Monogr Eval Carcinog Risks Hum. 2007, 89: 55-60.",{},{"id":18,"text":405,"url":18,"identifiers":406},"Royal College of Physicians, Tobacco Advisory Group: Harm Reduction in Nicotine Addiction: Helping People Who Can’t Quit. 2007, London: RCP",{},{"id":18,"text":408,"url":18,"identifiers":409},"Rodgman A, Perfetti T: The Chemical Components of Tobacco and Tobacco Smoke. 2009, Boca Raton, FL: CRC Press, 1259-",{},{"id":18,"text":411,"url":18,"identifiers":412},"Hecht S: Recommendations from the Tobacco Product Constituents Subcommittee, 2010. 2010, : US Food and Drug Administration, http:\u002F\u002Fwww.fda.gov\u002Fdownloads\u002FAdvisoryCommittees\u002FCommitteesMeetingMaterials\u002FTobaccoProductsScientificAdvisoryCommittee\u002FUCM224807.pdf,",{},{"id":18,"text":414,"url":18,"identifiers":415},"Office of Science in the Center for Tobacco Products at the US Food and Drug Administration: Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke: Established List. 2012, US Food and Drug Administration, http:\u002F\u002Fwww.fda.gov\u002FTobaccoProducts\u002FGuidanceComplianceRegulatoryInformation\u002Fucm297786.htm,",{},{"id":18,"text":417,"url":18,"identifiers":418},"Office of Science in the Center for Tobacco Products at the US Food and Drug Administration: Reporting Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke Under Section 904(a)(3) of the Federal Food, Drug, and Cosmetic Act: Guidance for Industry, 2012. 2012, US Food and Drug Administration, http:\u002F\u002Fwww.fda.gov\u002FTobaccoProducts\u002FGuidanceComplianceRegulatoryInformation\u002Fucm297752.htm,",{},{"id":18,"text":420,"url":18,"identifiers":421},"Digard H, Errington G, Richter A, McAdam K: Patterns and behaviors of snus consumption in Sweden. Nicotine Tob Res. 2009, 11: 1175-1181. 10.1093\u002Fntr\u002Fntp118.",{"doi":422},"10.1093\u002Fntr\u002Fntp118",{"id":18,"text":424,"url":18,"identifiers":425},"Digard H, Proctor C, Kulasekaran A, Malmqvist U, Richter A: Determination of nicotine absorption from multiple tobacco products and nicotine gum. Nicotine Tob Res. 2013, 15: 255-261. 10.1093\u002Fntr\u002Fnts123.",{"doi":426},"10.1093\u002Fntr\u002Fnts123",{"id":18,"text":428,"url":18,"identifiers":429},"Hecht S, Carmella S, Murphy S, Riley W, Le C, Luo X, Mooney M, Hatsukami D: Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers. Cancer Epidemiol Biomarkers Prev. 2007, 16: 1567-1572. 10.1158\u002F1055-9965.EPI-07-0227.",{"doi":430},"10.1158\u002F1055-9965.EPI-07-0227",{"id":18,"text":432,"url":18,"identifiers":433},"Lunell E, Lunell M: Steady-state nicotine plasma levels following use of four different types of Swedish snus compared with 2-mg Nicorette chewing gum: a crossover study. Nicotine Tob Res. 2005, 7: 397-403. 10.1080\u002F14622200500125468.",{"doi":434},"10.1080\u002F14622200500125468",{"id":18,"text":436,"url":18,"identifiers":437},"Pappas R, Stanfill S, Watson C, Ashley D: Analysis of toxic metals in commercial moist snuff and Alaskan iqmik. J Anal Toxicol. 2008, 32: 281-291.",{"doi":438},"10.1093\u002Fjat\u002F32.4.281",{"id":18,"text":440,"url":18,"identifiers":441},"Andersson G, Bjornberg G, Curvall M: Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study. J Oral Pathol Med. 1994, 23: 161-167. 10.1111\u002Fj.1600-0714.1994.tb01106.x.",{"doi":442},"10.1111\u002Fj.1600-0714.1994.tb01106.x",{"id":18,"text":444,"url":18,"identifiers":445},"Lunell E, Curvall M: Nicotine delivery and subjective effects of Swedish portion snus compared with 4 mg nicotine polacrilex chewing gum. Nicotine Tob Res. 2011, 13: 573-578. 10.1093\u002Fntr\u002Fntr044.",{"doi":446},"10.1093\u002Fntr\u002Fntr044",{"id":18,"text":448,"url":18,"identifiers":449},"Caraway J, Chen P: Assessment of mouth-level exposure to tobacco constituents in US snus consumers. Nicotine Tob Res. 2012, 10.1093\u002Fntr\u002Fnts187. [online early access],Published Online: September 18, 2012",{},{"id":18,"text":451,"url":18,"identifiers":452},"Bardow A, Madsen J, Nauntofte B: The bicarbonate concentration in human saliva does not exceed the plasma level under normal physiological conditions. Clin Oral Investig. 2000, 4: 245-253. 10.1007\u002Fs007840000077.",{"doi":453},"10.1007\u002Fs007840000077",{"id":18,"text":455,"url":18,"identifiers":456},"Lunell E, Lunell M: In-vivo extraction of lead, cadmium and tobacco specific nitrosamines from four brands of Swedish snus in regular snus users [abstract]. 2005, Presented at 11th Annual Meeting and 7th Annual European Conference of the Society for Research on Nicotine and Tobacco, Prague, Czech Republic, March 20–23, 2005; Rapid Communications Poster Abstract RP-076. http:\u002F\u002Fwww.srnt.org\u002Fconferences\u002Fabstracts\u002Fpdfs\u002F2005_Abstracts.pdf",{},{"id":18,"text":458,"url":18,"identifiers":459},"Calpena A, Clares B, Fernandez F: Technological, biopharmaceutical and pharmacokinetic advances: new formulations of application on the skin and oral mucosa. Recent Advances in Pharmaceutical Sciences. Edited by: Munoz-Torrero D. 2011, Kerala, India: Transworld Research Network, 175-198.",{},{"id":18,"text":461,"url":18,"identifiers":462},"Siegel I: Permeability of the oral mucosa. The Structure and Function of Oral Mucosai. Edited by: Meyer J, Squier C, Gerson S. 1984, Oxford, UK: Pergamon Press, 95-108.",{},{"id":18,"text":464,"url":18,"identifiers":465},"Taebunpakul S, Liu C, Wright C, McAdam K, Heroult J, Braybrook J, Goenaga-Infante H: Determination of total arsenic and arsenic speciation in tobacco products: from tobacco leaf and cigarette smoke. J Anal At Spectrom. 2011, 26: 1633-1640. 10.1039\u002Fc0ja00268b.",{"doi":466},"10.1039\u002Fc0ja00268b",{"id":18,"text":468,"url":18,"identifiers":469},"SRC Inc Interactive PhysProp Database Demo. http:\u002F\u002Fwww.syrres.com\u002Fwhat-we-do\u002Fdatabaseforms.aspx?id=386\u002F,",{},{"id":18,"text":471,"url":18,"identifiers":472},"Royal Society of Chemistry ChemSpider. http:\u002F\u002Fwww.chemspider.com\u002F,",{},{"id":18,"text":474,"url":18,"identifiers":475},"Williamson J, Digard H, Richter A, McAdam K: Development of a laboratory based analysis system for measurement of snus constituent extraction by users. Presented at the 2009 Joint Conference of the Society for Research on Nicotine and Tobacco (SRNT) and SRNT-Europe, Saggart, Republic of Ireland, April 27–30, 2009; Poster POS3-35. 2009",{},{"id":477,"createTime":478,"updateTime":479,"relativeEntities":480,"slug":481,"properties":482,"entityType":113,"verifyStatus":114,"verifyTime":479,"verifyNote":115,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":491,"fullTextUrl":18,"authors":492,"publicationType":236,"publisherRelationship":602,"citationCount":18,"citationInfo":18,"publishDate":625,"publishYear":626,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":264},"9a941806-2116-4e51-8224-4f8d85ca4498","2024-01-17T18:34:01.298+00:00","2024-09-30T23:55:12.831+00:00",[],"GC-MS-studies-of-the-chemical-composition-of-two-inedible-mushrooms-of-the-genus-Agaricus",{"references":483,"abstract":485,"title":487,"doi":489},{"VOID":484},"Calvo-Bado LC, Noble R, Challen M, Dobrovin-Pennington A, Elliott T: Sexuality and Genetic Identity in the Agaricus Section Arvenses. Appl Environl Microbiology. 2000, 66: 728-734. 10.1128\u002FAEM.66.2.728-734.2000.\nKuo M: Agaricus placomyces. (accessed on 19.10.2007), [http:\u002F\u002Fwww.mushroomexpert.com\u002Fagaricus_placomyces.html]\nAgaricus pseudopratensis var. pseudopratensis. (accessed on 19.10.2007), [http:\u002F\u002Fwww.deltadelpo.it\u002Fleggi.asp?articolo=463&posizione=426]\nPallaci Callaci, Guinbertau J, Rapior S: New Hypotheses from Integration of Morphological Traits Biochemical Data and Molecular Phylogeny in Agaricus spp. The 5th ICMBMP April 2005. (accessed on 21.10.2007), [http:\u002F\u002Fwww.shroomtalk.com\u002Fforum\u002Flofiversion\u002Findex.php\u002Ft7455.html]\nDel Signore A, Romeo F, Giaccio M: Content of phenolic substance in basidiomycetes. Mycol Res. 1997, 101: 552-556. 10.1017\u002FS0953756296003206.\nStoop JMH, Mooibroek H: Advances in genetic analysis and biotechnology of the cultivated button mushroom, Agaricus bisporus. Appl Microbiol Biotechnol. 1999, 52: 474-483. 10.1007\u002Fs002530051548.\nLewis DH, Smith DC: Sugar Alcohols (Polyols) in Fungi and Green Plants. I. Distribution, Physiology and Metabolism. New Phytologist. 1967, 66: 143-184. 10.1111\u002Fj.1469-8137.1967.tb05997.x.\nWagemaker MJM, Welboren W, van der Drift C, Jetten MSM, Van Griensven LJLD, Op den Camp HJM: The ornithine cycle enzyme arginase from Agaricus bisporus and its role in urea accumulation in fruiting bodies. Biochim Biophys Acta (BBA) – Gene Structure and Expression. 2005, 1681: 107-115. 10.1016\u002Fj.bbaexp.2004.10.007.\nWagemaker MJM, Eastwood DC, van der Drift C, Jetten MSM, Burton K, Van Griensven LJLD, Op den Camp HJM: Expression of the urease gene of Agaricus bisporus: a tool for studying fruiting body formation and post-harvest development. Appl Microbiol Biotechnol. 2006, 71: 486-492. 10.1007\u002Fs00253-005-0185-5.\nGauvin A, Smadja J, Aknin M, Faure R, Gaydou E-M: Isolation of bioactive 5a,8a-epidioxy sterols from the marine sponge Luffariella cf. variabilis. Can J Chem. 2000, 78: 986-992. 10.1139\u002Fcjc-78-7-986.\nGill M, Strauch RJ: Constituents of Agaricus xanthodermus Genevier: the first naturally endogenous azo compound and toxic phenolic metabolites. Z Naturforsch [C]. 1984, 39: 1027-1029.\nHendriks H, Geerts HJ, Malingre M: The occurrence of valeranone and crypto-fauronol in the essential oil of Valeriana officinalis L. s. l. collected in the northern part of The Netherlands. Pharmac Wekblad Scient Edition. 1981, 116: 1316-1320. 10.1007\u002FBF02193381.",{"EN":486},"Mushrooms in the genus Agaricus have worldwide distribution and include the economically important species A. bisporus. Some Agaricus species are inedible, including A. placomyces and A. pseudopratensis, which are similar in appearance to certain edible species, yet are known to possess unpleasant odours and induce gastrointestinal problems if consumed. We have studied the chemical composition of these mushrooms using GC-MS. Our GC-MS studies on the volatile fractions and butanol extracts resulted in the identification of 44 and 34 compounds for A. placomyces and A. pseudopratensis, respectively, including fatty acids and their esters, amino acids, and sugar alcohols. The most abundant constituent in the volatiles and butanol were phenol and urea respectively. We also identified the presence of ergosterol and two Δ7-sterols. In addition, 5α,8α-Epidioxi-24(ξ)-methylcholesta-6,22-diene-3β-ol was isolated for the first time from both mushrooms. Our study is therefore the first report on the chemical composition of these two species. The results obtained contribute to the knowledge of the chemical composition of mushrooms belonging to the Agaricus genus, and provide some explanation for the reported mild toxicity of A. placomyces and A. pseudopratensis, a phenonomenon that can be explained by a high phenol content, similar to that found in other Xanthodermatei species.",{"EN":488},"GC-MS studies of the chemical composition of two inedible mushrooms of the genus Agaricus",{"VOID":490},"10.1186\u002F1752-153X-1-33","https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-153X-1-33",[493,510,522,534,546,558,570,585],{"id":494,"sortIndex":19,"researcher":18,"roles":495,"affiliations":496,"properties":507},"427bf3bb-411d-493f-91bd-048553986e09",[122],[497],{"id":18,"sortIndex":19,"affiliation":498,"properties":18},{"id":499,"createTime":500,"updateTime":501,"relativeEntities":502,"slug":503,"properties":504,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"508e4ae8-5c0c-4b53-9b4d-5d9ea92a06f2","2023-12-26T05:10:44.628+00:00","2024-11-27T18:20:38.403+00:00",[],"Institute-of-Organic-Chemistry-with-Centre-of-Phytochemistry-Bulgarian-Academy-of-Sciences-Sofia-Bulgaria",{"title":505},{"VI":506},"Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria",{"title":508},{"VI":509},"Assya Petrova",{"id":511,"sortIndex":138,"researcher":18,"roles":512,"affiliations":513,"properties":519},"839d8d11-f2f1-4923-949c-74e927a6be50",[122],[514],{"id":18,"sortIndex":19,"affiliation":515,"properties":18},{"id":499,"createTime":500,"updateTime":501,"relativeEntities":516,"slug":503,"properties":517,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":518},{"VI":506},{"title":520},{"VI":521},"Kalina Alipieva",{"id":523,"sortIndex":120,"researcher":18,"roles":524,"affiliations":525,"properties":531},"0d8b755f-19c0-4a0f-9626-98e44612179d",[122],[526],{"id":18,"sortIndex":19,"affiliation":527,"properties":18},{"id":499,"createTime":500,"updateTime":501,"relativeEntities":528,"slug":503,"properties":529,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":530},{"VI":506},{"title":532},{"VI":533},"Emanuela Kostadinova",{"id":535,"sortIndex":207,"researcher":18,"roles":536,"affiliations":537,"properties":543},"905388bc-ccc8-4ecc-bae8-49873ceafe32",[122],[538],{"id":18,"sortIndex":19,"affiliation":539,"properties":18},{"id":499,"createTime":500,"updateTime":501,"relativeEntities":540,"slug":503,"properties":541,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":542},{"VI":506},{"title":544},{"VI":545},"Vassya Bankova",{"id":547,"sortIndex":169,"researcher":18,"roles":548,"affiliations":549,"properties":555},"04a9b030-75c0-44bc-804f-af5f6b357a8b",[122],[550],{"id":18,"sortIndex":19,"affiliation":551,"properties":18},{"id":499,"createTime":500,"updateTime":501,"relativeEntities":552,"slug":503,"properties":553,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":554},{"VI":506},{"title":556},{"VI":557},"Simeon Popov",{"id":559,"sortIndex":194,"researcher":18,"roles":560,"affiliations":561,"properties":567},"50c14059-3545-4e82-93fc-1acc8fb9356b",[122],[562],{"id":18,"sortIndex":19,"affiliation":563,"properties":18},{"id":499,"createTime":500,"updateTime":501,"relativeEntities":564,"slug":503,"properties":565,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":566},{"VI":506},{"title":568},{"VI":569},"Daniela Antonova",{"id":571,"sortIndex":225,"researcher":18,"roles":572,"affiliations":573,"properties":582},"ecfe842a-b0be-4ee4-83a0-849617bb8976",[122],[574],{"id":18,"sortIndex":19,"affiliation":575,"properties":18},{"id":576,"createTime":577,"updateTime":577,"relativeEntities":578,"slug":18,"properties":579,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"b06a872b-ae43-44d4-a0b8-b5060bd60bcf","2024-01-17T18:34:01.363+00:00",[],{"title":580},{"VI":581},"Department of Botany and Agrimeteorology, Agricultural University, Plovdiv, Bulgaria",{"title":583},{"VI":584},"Maria Lacheva",{"id":586,"sortIndex":84,"researcher":18,"roles":587,"affiliations":588,"properties":599},"5d17cda9-a083-4516-bacc-8f20f5dc25d4",[122],[589],{"id":18,"sortIndex":19,"affiliation":590,"properties":18},{"id":591,"createTime":592,"updateTime":593,"relativeEntities":594,"slug":595,"properties":596,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"206c7476-1f86-48c7-b1f2-44693428fb64","2024-01-22T06:43:21.459+00:00","2024-10-09T07:21:37.062+00:00",[],"Institute-of-Botany-Bulgarian-Academy-of-Sciences-Sofia-Bulgaria",{"title":597},{"VI":598},"Institute of Botany, Bulgarian Academy of Sciences, Sofia, Bulgaria",{"title":600},{"VI":601},"Melania Gjosheva",{"url":491,"publisher":603,"properties":622},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":604,"slug":10,"properties":605,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":608,"manageAffiliations":609,"indexDatabases":610,"url":18,"thumbnailPath":18,"statistic":617,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":606,"title":607},{"VOID":13},{"EN":15},[],[],[611],{"id":24,"indexDatabase":612,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":613,"label":614,"description":615,"key":34,"publicationTags":616,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":618,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":619,"totalCitation":65,"totalCitationByYear":620,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":621,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":623,"pages":624},{"VOID":395},{"VOID":261},"2007-12-20",2007,{"id":628,"createTime":629,"updateTime":630,"relativeEntities":631,"slug":632,"properties":633,"entityType":113,"verifyStatus":114,"verifyTime":630,"verifyNote":115,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":642,"fullTextUrl":18,"authors":643,"publicationType":236,"publisherRelationship":717,"citationCount":18,"citationInfo":18,"publishDate":742,"publishYear":743,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":264},"0a6123ef-3bb1-4bf1-9e97-257d94b83448","2024-01-25T05:22:24.263+00:00","2025-01-19T23:52:54.548+00:00",[],"Microwave-synthesis-and-thermal-properties-of-polyacrylate-derivatives-containing-itaconic-anhydride-moieties",{"references":634,"abstract":636,"title":638,"doi":640},{"VOID":635},"Lidstrom P, Tierney J, Wathey B, Westman J: Microwave-assisted organic synthesis a review. Tetrahedron. 2001, 57: 9225-9283.\nPerrux L, Loupy AA: Tentative realization of microwave effects in organic synthesis according to the reaction medium and mechanistic consideration. Tetrahedron. 2001, 57: 9199-9223. 10.1016\u002FS0040-4020(01)00905-X.\nCaddick S: Microwave-assisted organic-reactions. Tetrahedron. 1995, 51: 10403-10432. 10.1016\u002F0040-4020(95)00662-R.\nMatloobi M, Kappe CO: Microwave synthesis in high-throughput environments. Moving from automated sequential to microtiter plate formats. Chim. Oggi. 2007, 2007 (25): 26-31.\nMallakpour S, Rafiee Z: Application of microwave-assisted reactions in step-growth polymerization: A review. Iran. Poly. J. 2008, 17: 907-935.\nAdam D: Out of the kitchen. Nature. 2003, 421: 571-572. 10.1038\u002F421571a.\nLoupy A: Solvent-free microwave organic synthesis as an efficient procedure for green chemistry. Chimie. 2004, 7: 103-112. 10.1016\u002Fj.crci.2003.10.015.\nLerestif JM, Toupet L, Sun-bandhit S, Tonnard F, Bazureau JP, Hamelin J: A new route to 2-oxazolines, bis-oxazolines, and 2-imidazoline-5-ones from imidates using solvent-free cycloadditions: Synthesis, chemical properties, and PM3 MO calculations. Tetrahedron. 1997, 53: 6351-6364. 10.1016\u002FS0040-4020(97)00295-0.\nVarma RS, Dahiya R, Kumar S: Clay catalyzed synthesis of imines and enamines under solvent-free conditions using microwave irradiation. Tetrahedron Lett. 1997, 38: 2039-2042. 10.1016\u002FS0040-4039(97)00261-X.\nVarma RS: Clay and clay-supported reagents in organic synthesis. Tetrahedron. 2002, 58: 1235-1255. 10.1016\u002FS0040-4020(01)01216-9.\nKarah N: Synthesis and primary cytotoxicity evaluation of new 5-nitroindole-2,3-dione derivatives. Eur. J. Med. Chem. 2002, 37: 909-918. 10.1016\u002FS0223-5234(02)01416-2.\nKidwai M: Dry media reactions. Pure Appl. Chem. 2001, 73: 147-151. 10.1351\u002Fpac200173010147.\nRaval JP, Desai KR: Synthesis and antimicrobial activity of new triazolopyridinyl phenothiazines. Arkivoc. 2005, xiii: 21-28.\nRaval JP, Desai KG, Desai KR: Neat reaction technology for the synthesis of 4-oxothiazolidines derived from 2-SHBenzothiazole and antimicrobial screening of some synthesized 4-thiazolidinones. J. Iranian Chem. Soc. 2006, 3: 233-241. 10.1007\u002FBF03247213.\nRaval JP, Desai JT, Desai CK, Desai KR: A comparative study of microwave assisted and conventional synthesis of 2,3-dihydro-2-aryl-4-[4-(2–oxo–2H–chromen–3–yl)–1,3-thiazol–2–ylamino]-1,5–benzothiazepines and its antimicrobial activity. Arkivoc. 2008, xii: 233-244.\nRaval JP, Desai KR: A comparative study of microwave assisted and conventional Synthesis of novel 2-(4-diethylamino-2-hydroxyphenyl)-3-substituted-thiazolidin-4-one derivatives. Chemija. 2009, 20: 101-108.\nRaval JP, Patel HV, Patel PS, Patel NH, Desai KR: A rapid, convenient microwave assisted and conventional synthesis of novel azetidin-2-one derivatives as potent antimicrobial agents. Asian J. Res. Chem. 2009, 2: 171-177.\nAl-Hazimi HM, El-Faham A, Ghazzali M, Al-Farhan K: Microwave irradiation: A facile, scalable and convenient method for synthesis of N-phthaloylamino acids. Arab. J. Chem. 2012, 5: 285-289. 10.1016\u002Fj.arabjc.2010.06.020.\nGhazzali M, El-Faham A, Abd-Megeed A, Al-Farhan K: Microwave-assisted synthesis, structural elucidation and biological assessment of 2-(2-acetamidophenyl)-2-oxo-N-phenyl acetamide and N-(2-(2-oxo-2(phenylamino)acetyl)phenyl)-propionamide derivatives. J. Mol. Str. 2012, 1013: 163-167.\nJullien H, Valot H: Polyurethane curing by a pulsed microwave field. Polymer. 1985, 26: 506-510. 10.1016\u002F0032-3861(85)90149-1.\nSilinski B, Kuzmycz C, Gourdenne A: Synthesis under microwaves (2.45 GHz) of polyurethane polymers-I. Model study from diisocyanate and polyethertriol prepolymers. Eur. Polym. J. 1987, 23: 273-277. 10.1016\u002F0014-3057(87)90147-9.\nImai Y, Nemoto H, Watanabe S, Kakimoto MA: A new facile and rapid synthesis of aliphatic polyamides by microwave assisted polycondensation of ω-amino acids and nylon salts. Polym. J. 1996, 28: 256-260. 10.1295\u002Fpolymj.28.256.\nLiu Y, Sun XD, Xie XQ, Scola DA: Kinetics of the crosslinking reaction of a bisnadimide model compound in thermal and microwave cure processes. J. Polym. Sci., Part A, Polym. Chem. 1998, 36: 2653-2665. 10.1002\u002F(SICI)1099-0518(199810)36:14\u003C2653::AID-POLA25>3.0.CO;2-G.\nWallach JA: Biodegradable polymers derived from renewable resources: highly branched copolymers of itaconic anhydride. Polym. Sci. Edited by: Storrs CT. 2000, University of Connecticut\nMeier MAR, Metzger JO, Schubert US: Plant oil renewable resources as green alternatives in polymer science. Chem. Soc. Rev. 2007, 36: 1788-17802. 10.1039\u002Fb703294c.\nPapanu VD: Amide-imide derivatives of homopolymers of itaconic anhydride having antitumor activity. application: EP. 1983, USA: Monsanto Co, 18-\nMilovanovic MB, Trifunovic SS, Katsikas L, Popovic IG: Preparation and modification of itaconic anhydride–methyl methacrylate copolymers. J. Serb. Chem. Soc. 2007, 72 (12): 1507-1514. 10.2298\u002FJSC0712507M.\nCismaru L, Hamaide T, Popa M: Itaconic anhydride based amphiphilic copolymers: synthesis, characterization and stabilization of carboxyl functionalized. PEGylated nanoparticles. Eur. Polym. J. 2007, 43: 4843-4851.\nShang S, Huang SJ, Weiss RA: Synthesis and characterization of itaconic anhydride and stearyl methacrylate copolymers. Polymer. 2009, xxx: 1-9.\nErbil C, Terlan B, Akdemir O, Gokceoren AT: Monomer reactivity ratios of N-isopropylacrylamide–itaconic acid copolymers at low and high conversions. Eur. Polym. J. 2009, 45: 1728-1737. 10.1016\u002Fj.eurpolymj.2009.02.023.\nMormann W, Ferbitz J: Copolymers from tert-butyl methacrylate and itaconic anhydride-reactivity ratios and polymer analogous reactions. Eur. Polym. J. 2003, 39: 489-496. 10.1016\u002FS0014-3057(02)00246-X.\nKun RC, Soykan C, Delibas A: Study of free-radical copolymerization of itaconic acid\u002F2-acrylamido-2-methyl-1-propanesulfonic acid and their metal chelates. Eur. Polym. J. 2006, 42: 625-637. 10.1016\u002Fj.eurpolymj.2005.08.018.\nBajaj P, Paliwal DK, Gupta AK: Acrylonitrile-acrylic acids copolymers I synthesis and characterization. J. Appl. Polym. Sci. 1993, 49: 823-833. 10.1002\u002Fapp.1993.070490508.\nXue W, Champ S, Huglin MB: Observations on some copolymerisations involving N-isopropylacrylamide. Polymer. 2000, 41: 7575-7581. 10.1016\u002FS0032-3861(00)00171-3.\nCowie JMG, McEwen IJ, Yule DJ: The influence of solvent on the apparent reactivity ratios in free radical copolymerisation reactions between itaconic acid and 2-hydroxyethyl acrylate. Eur. Polym. J. 2000, 36: 1795-1803. 10.1016\u002FS0014-3057(99)00257-8.\nUyanık N, Erbil C: Monomer reactivity ratios of itaconic acid and acrylamide copolymers determined by using potentiometric titration method. Eur. Polym. J. 2000, 36: 2651-2654. 10.1016\u002FS0014-3057(00)00045-8.\nErbil C, Ozdemir S, Uyanık N: Determination of the monomer reactivity ratios for copolymerization of itaconic acid and acrylamide by conductometric titration method. Polymer. 2000, 41: 1391-1394. 10.1016\u002FS0032-3861(99)00291-8.\nVirtanen J, Tenhu H: Studies on copolymerization of N-isopropylacrylamide and glycidyl methacrylate. J. Polym. Sci. Pol. Chem. 2001, 39: 3716-3725. 10.1002\u002Fpola.10017.\nDevasia R, Nair CPR, Ninan KN: Copolymerization of acrylonitrile with itaconic acid in dimethylformamide: effect of triethylamine. Eur. Polym. J. 2003, 39: 537-544. 10.1016\u002FS0014-3057(02)00275-6.\nPatel MV, Dolia MB, Patel JN, Patel RM: Synthesis and characterization of novel acrylic copolymers: determination of monomer reactivity ratios and biological activity. React. Funct. Polym. 2005, 65: 195-204. 10.1016\u002Fj.reactfunctpolym.2005.08.002.\nPekel N, S_ahiner N, Guven O, Rızaev ZMO: Synthesis and characterization of N-vinylimidazole–ethyl methacrylate copolymers and determination of monomer reactivity ratios. Eur. Polym. J. 2001, 37: 2443-2451. 10.1016\u002FS0014-3057(01)00124-0.\nSave NS, Jassal M, Agrawal AK: Stimuli sensitive copolymer poly (N-tert-butylacrylamide-ran-acrylamide): synthesis and characterization. J. Appl. Polym. Sci. 2005, 95: 672-680. 10.1002\u002Fapp.21216.\nOishi T: Polymerizations and copolymerizations of N-(4-substituted phenyl)itaconimides. Polym. J. 1980, 12: 719-727. 10.1295\u002Fpolymj.12.719.\nUrzua M, Opazo A, Gargallo L, Radić D: Poly(N-1-alkylitaconamic acids) \u002Fpoly(N-vinyl-2-pyrrolidone) blends. Polym. Bull. 1998, 40: 63-67. 10.1007\u002Fs002890050224.\nShang S, Huang SJ, Weiss RA: Synthesis and characterization of itaconic anhydride and stearyl methacrylate copolymers. Polymer. 2009, 50: 3119-3127. 10.1016\u002Fj.polymer.2009.05.012.\nEhrenstein GW, Riedel G, Trawiel P: Thermal analysis of plastics: Theory and practice. Hanser Gardner Publications. 2004, ISBN-13: 9781569903629-\nKrušić KM, Džunuzović E, Trifunović S, Filipović J: Polyacrylamide and poly(itaconic acid) complexes. Eur. Polym. J. 2004, 40: 793-798. 10.1016\u002Fj.eurpolymj.2003.11.016.\nFellows CM: Preliminary observations on the copolymerisation of acceptor monomer:donor monomer systems under microwave irradiation. Central Eur J Chem. 2005, 3: 40-52. 10.2478\u002FBF02476236.",{"EN":637},"Microwave irradiation as an alternative heat source is now a well-known method in synthetic chemistry. Microwave heating has emerged as a powerful technique to promote a variety of chemical reactions, offering reduced pollution, low cost and offer high yields together with simplicity in processing and handling. On the other hand, copolymers containing both hydrophilic and hydrophobic segments are drawing considerable attention because of their possible use in biological systems. Various copolymer compositions can produce a very large number of different arrangements, producing materials of varying chemical and physical properties. Thus, the hydrophilicity of copolymers can be modified by changing the amount of incorporated itaconic anhydride. A series of methyl methacrylate (MMA) and acrylamide (AA) copolymers containing itaconic anhydride (ITA) were synthesized by microwave irradiation employing a multimode reactor (Synthos 3000 Aton Paar, GmbH, 1400 W maximum magnetron) as well as conventional method. The thermal properties of the copolymers were evaluated by different techniques. Structure-thermal property correlation based on changing the itaconic anhydride ratio was demonstrated. Results revealed that the incorporation of itaconic anhydride into the polymeric backbone of all series affect the thermal stability of copolymers. In addition, the use of the microwave method offers high molecular weight copolymers which lead eventually to an increase in thermal stability. Microwave irradiation method showed advantages for the produced copolymers compared to that prepared by conventional method, where it can offer a copolymer in short time, high yield, more pure compounds and more thermally stable copolymers, rather than conventional method. Also, microwave irradiation method gives higher molecular weight due to prevention of the chain transfer. Moreover, as the itaconic anhydride content increases the thermal stability and T\n                    g\n                   increase due to the decrease in the crystallinity.",{"EN":639},"Microwave synthesis and thermal properties of polyacrylate derivatives containing itaconic anhydride moieties",{"VOID":641},"10.1186\u002F1752-153X-6-85","https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-153X-6-85",[644,671,683,695],{"id":645,"sortIndex":138,"researcher":18,"roles":646,"affiliations":647,"properties":668},"ca4a8ecb-f2b8-4336-a8c8-8491e7ecd269",[122],[648,656],{"id":18,"sortIndex":19,"affiliation":649,"properties":18},{"id":650,"createTime":651,"updateTime":651,"relativeEntities":652,"slug":18,"properties":653,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"707a754d-a704-4218-8265-3cd45beac4e8","2024-01-05T21:29:35.413+00:00",[],{"title":654},{"VI":655},"Petrochemical Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia",{"id":657,"sortIndex":138,"affiliation":658,"properties":667},"6e8656a8-9693-4af1-9046-dd3c90cef5be",{"id":659,"createTime":660,"updateTime":661,"relativeEntities":662,"slug":663,"properties":664,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"731a0b91-1c6f-4125-88c0-7b84042529a9","2023-12-13T03:19:14.289+00:00","2024-10-11T17:29:06.561+00:00",[],"Department-of-Chemistry-Faculty-of-Science-Tanta-University-Tanta-Egypt",{"title":665},{"VI":666},"Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt",{},{"title":669},{"VI":670},"Mohamed H El-Newehy",{"id":672,"sortIndex":120,"researcher":18,"roles":673,"affiliations":674,"properties":680},"a301e5dc-6400-4c3d-8b30-4864763f5ae8",[122],[675],{"id":18,"sortIndex":19,"affiliation":676,"properties":18},{"id":650,"createTime":651,"updateTime":651,"relativeEntities":677,"slug":18,"properties":678,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":679},{"VI":655},{"title":681},{"VI":682},"Salem S Al-Deyab",{"id":684,"sortIndex":19,"researcher":18,"roles":685,"affiliations":686,"properties":692},"c1d26fea-f48c-46d5-8093-af3d0cc4a50b",[122],[687],{"id":18,"sortIndex":19,"affiliation":688,"properties":18},{"id":650,"createTime":651,"updateTime":651,"relativeEntities":689,"slug":18,"properties":690,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":691},{"VI":655},{"title":693},{"VI":694},"Sameh M Osman",{"id":696,"sortIndex":194,"researcher":18,"roles":697,"affiliations":698,"properties":714},"2575b3e6-e426-45a1-960b-60584aecbc11",[122],[699,704],{"id":18,"sortIndex":19,"affiliation":700,"properties":18},{"id":650,"createTime":651,"updateTime":651,"relativeEntities":701,"slug":18,"properties":702,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":703},{"VI":655},{"id":705,"sortIndex":138,"affiliation":706,"properties":713},"11245b58-0c02-4487-af0d-e26243b8dad2",{"id":707,"createTime":708,"updateTime":708,"relativeEntities":709,"slug":18,"properties":710,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"1591b006-682f-4e21-aea0-5e382d3d507c","2024-01-25T05:22:24.322+00:00",[],{"title":711},{"VI":712},"Chemistry Department, Alexandria University, Faculty of Science, Ibrahimia, Egypt",{},{"title":715},{"VI":716},"Ayman El-Faham",{"url":642,"publisher":718,"properties":737},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":719,"slug":10,"properties":720,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":723,"manageAffiliations":724,"indexDatabases":725,"url":18,"thumbnailPath":18,"statistic":732,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":721,"title":722},{"VOID":13},{"EN":15},[],[],[726],{"id":24,"indexDatabase":727,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":728,"label":729,"description":730,"key":34,"publicationTags":731,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":733,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":734,"totalCitation":65,"totalCitationByYear":735,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":736,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":738,"pages":740},{"VOID":739},"6",{"VOID":741},"1-11","2012-08-08",2012,{"id":745,"createTime":746,"updateTime":747,"relativeEntities":748,"slug":749,"properties":750,"entityType":113,"verifyStatus":114,"verifyTime":747,"verifyNote":115,"syncStatus":17,"languages":766,"translateLanguages":18,"viewCount":19,"primaryUrl":767,"fullTextUrl":18,"authors":768,"publicationType":236,"publisherRelationship":853,"citationCount":84,"citationInfo":877,"publishDate":879,"publishYear":880,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":881,"isForceReanalyzing":264},"c025ce32-13d5-4fae-9597-584179b11ea6","2024-04-19T20:11:49.612+00:00","2025-01-04T23:51:49.616+00:00",[],"Simple-and-green-technique-for-sequestration-and-concentration-of-silver-nanoparticles-by-polysaccharides-immobilized-on-glass-beads-in-aqueous-media",{"mag":751,"keywords":753,"pmc":754,"openalex":756,"abstract":758,"title":760,"pm":762,"doi":764},{"VOID":752},"1545709963",{},{"VOID":755},"4464050",{"VOID":757},"W1545709963",{"EN":759},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Engineered nanoparticles have unique properties compared to bulk materials and their commercial uses growing rapidly. They represent a potential risk for environment and health and could be eventually released in water. Silver nanoparticles (Ag NP) are applied in various products and are well-known for their antibacterial properties. Nowadays, pre-concentration and separation methods for Ag NP possess some limitations. Here, we present a simple, green method to sequestrate and concentrate Ag NP from different aqueous media.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>Supported polysaccharides on glass beads synthesized in water by a single step reaction show high sequestration capacity of citrate-coated Ag NP in aqueous media. Supported polysaccharides were characterized by infrared spectroscopy, scanning electron microscopy (SEM) and elemental analysis. Sequestration of 83.0 % of Ag NP was attained from a 20 μg.L\u003Cjats:sup>−1\u003C\u002Fjats:sup> aqueous solution with supported chitosan in water whereas supported 2-hydroxyethylcellulose (HEC) reached 64.0 % in synthetic seawater in 2 h. The influence of polymer\u002Fglass beads ratio and molecular weight of polysaccharides was also studied. The effect of the salinity and humic acids on sequestration of Ag NP was investigated. Supported polymers have shown high performance for sequestration of ionic silver. Sequestration of 82.5 % and 80.8 % were obtained from a 60 μg.L\u003Cjats:sup>−1\u003C\u002Fjats:sup> silver ion (as nitrate salt) with supported HEC and chitosan, respectively. Sequestrated Ag NP was characterized with transmission electron microscopy (TEM) where images showed Ag NP with unchanged size and shape.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n            \u003Cjats:p>This sequestration method, involving green synthesis, allows efficient concentration and characterization of Ag NP from different aqueous media. This simple and fast method is a potential sustainable technique for elimination of Ag NP and ionic silver from waste waters and waters at different salinities.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":761},"Simple and green technique for sequestration and concentration of silver nanoparticles by polysaccharides immobilized on glass beads in aqueous media",{"VOID":763},"26075020",{"VOID":765},"10.1186\u002Fs13065-015-0110-7",[287],"https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13065-015-0110-7",[769,787,808,823,838],{"id":770,"sortIndex":225,"researcher":18,"roles":771,"affiliations":772,"properties":782},"2051f342-8cdd-4196-9144-72a35cdb3419",[],[773],{"id":774,"sortIndex":19,"affiliation":775,"properties":18},"2247c753-1485-4537-b0ec-66904fccf8e3",{"id":776,"createTime":777,"updateTime":777,"relativeEntities":778,"slug":18,"properties":779,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"633af584-fb30-4992-a068-b3f0f9b9fb7b","2023-12-07T18:31:53.423+00:00",[],{"title":780},{"VI":781},"Département de biologie, chimie et géographie, Université du Québec à Rimouski, 300, Allée des Ursulines, Rimouski (QC) G5L 3A1, Canada",{"openalex":783,"title":785},{"VOID":784},"A5010848179",{"EN":786},"Jonathan Gagnon",{"id":788,"sortIndex":194,"researcher":18,"roles":789,"affiliations":790,"properties":801},"761022c4-b013-4c4b-8012-f72dff669d83",[],[791],{"id":792,"sortIndex":19,"affiliation":793,"properties":18},"d548b6f5-af05-4a9f-a5b8-d85ef81b1f59",{"id":794,"createTime":795,"updateTime":795,"relativeEntities":796,"slug":797,"properties":798,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"9018810c-8f0f-407f-a0ed-afb708e0a50e","2024-04-19T20:11:49.671+00:00",[],"Centre-Saint-Laurent-Environment-Canada-105-McGill-st-7th-floor-Montreal-QC-H2Y-2E7-Canada",{"title":799},{"EN":800},"Centre Saint-Laurent, Environment Canada, 105 McGill st., 7th floor, Montreal, QC, H2Y 2E7, Canada",{"openalex":802,"orcid":804,"title":806},{"VOID":803},"A5027816815",{"VOID":805},"https:\u002F\u002Forcid.org\u002F0000-0003-4543-2264",{"EN":807},"Christian Gagnon",{"id":809,"sortIndex":138,"researcher":18,"roles":810,"affiliations":811,"properties":818},"a24f2a59-7c84-4d34-ad30-045e5277d221",[],[812],{"id":813,"sortIndex":19,"affiliation":814,"properties":18},"bf2cf0a3-cad3-4c95-bab4-d7003ab25d5f",{"id":776,"createTime":777,"updateTime":777,"relativeEntities":815,"slug":18,"properties":816,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":817},{"VI":781},{"openalex":819,"title":821},{"VOID":820},"A5015289633",{"EN":822},"Alexandre Dionne",{"id":824,"sortIndex":120,"researcher":18,"roles":825,"affiliations":826,"properties":833},"a56b9a90-1d39-4651-8604-a70ee5f43017",[],[827],{"id":828,"sortIndex":19,"affiliation":829,"properties":18},"6714f2f9-0d76-4bfb-baf9-195c42954809",{"id":776,"createTime":777,"updateTime":777,"relativeEntities":830,"slug":18,"properties":831,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":832},{"VI":781},{"openalex":834,"title":836},{"VOID":835},"A5076471691",{"EN":837},"Roxanne Brion-Roby",{"id":839,"sortIndex":19,"researcher":18,"roles":840,"affiliations":841,"properties":848},"194f59a3-2d70-4cc3-b7ce-85394b1bce57",[],[842],{"id":843,"sortIndex":19,"affiliation":844,"properties":18},"ca907302-b3c5-4d30-958c-a031c6bb4f6c",{"id":776,"createTime":777,"updateTime":777,"relativeEntities":845,"slug":18,"properties":846,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":847},{"VI":781},{"openalex":849,"title":851},{"VOID":850},"A5019344259",{"EN":852},"Alaeddine Kibeche",{"url":18,"publisher":854,"properties":873},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":855,"slug":10,"properties":856,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":859,"manageAffiliations":860,"indexDatabases":861,"url":18,"thumbnailPath":18,"statistic":868,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":857,"title":858},{"VOID":13},{"EN":15},[],[],[862],{"id":24,"indexDatabase":863,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":864,"label":865,"description":866,"key":34,"publicationTags":867,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":869,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":870,"totalCitation":65,"totalCitationByYear":871,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":872,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":874,"issue":876},{"VOID":875},"9",{"VOID":395},{"total":84,"publishYear":18,"statisticByYear":878},{"2016":138,"2018":120,"2021":138,"2023":138},"2015-12-01",2015,[882,886,890,893,897,901,905,909,913,917,921,925,929,933,937,941,945,949,953,957,961,965,969,973,977,981,985,989,993],{"id":18,"text":883,"url":18,"identifiers":884},"Maurer-Jones MA, Gunsolus IL, Murphy CG, Haynes CL. Toxicity of engineered nanoparticles in the environment. Anal Chem. 2013;85:3036–49.",{"doi":885},"10.1021\u002Fac303636s",{"id":18,"text":887,"url":18,"identifiers":888},"Johnston HJ, Hutchison G, Christensen FM, Peters S, Hankin S, Stone V. A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol. 2010;40:328–46.",{"doi":889},"10.3109\u002F10408440903453074",{"id":18,"text":891,"url":18,"identifiers":892},"Pulit J, Banach M, Kowalski Z. Nanosilver-making difficult decisions. Ecological Chemistry Engineering. 2011;1:185–96.",{},{"id":18,"text":894,"url":18,"identifiers":895},"Nazar MF, Shah SS, Eastoe J, Khan AM, Shah A. Separation and recycling of nanoparticles using cloud point extraction with non-ionic surfactant mixtures. J Colloid Interface Sci. 2011;363:490–6.",{"doi":896},"10.1016\u002Fj.jcis.2011.07.070",{"id":18,"text":898,"url":18,"identifiers":899},"Benn TM, Westerhoff P. Nanoparticle silver released into water from commercially available sock fabrics. Environ Sci Technol. 2008;42:4133–9.",{"doi":900},"10.1021\u002Fes7032718",{"id":18,"text":902,"url":18,"identifiers":903},"Hou L, Li K, Ding Y, Li Y, Chen J, Wu X, et al. Removal of silver nanoparticles in simulated wastewater treatment processes and its impact on COD and NH4 reduction. Chemosphere. 2012;87:248–52.",{"doi":904},"10.1016\u002Fj.chemosphere.2011.12.042",{"id":18,"text":906,"url":18,"identifiers":907},"Gicheva G, Yordanov G. Removal of citrate-coated silver nanoparticles from aquous dispersions by using activated carbon. Colloids Surf A Physicochem Eng Asp. 2013;431:51–9.",{"doi":908},"10.1016\u002Fj.colsurfa.2013.04.039",{"id":18,"text":910,"url":18,"identifiers":911},"Myakonkaya O, Hu Z, Nazar MF, Eastoe J. Recycling functional colloids and nanoparticles. Chemistry A European J. 2010;16:11784–90.",{"doi":912},"10.1002\u002Fchem.201000942",{"id":18,"text":914,"url":18,"identifiers":915},"Hartmann G, Hutterer C, Schuster M. Ultra-trace determination of silver nanoparticles in water samples using cloud point extraction and ETAAS. J Analytical Atomic Spectrometry. 2013;28:567–72.",{"doi":916},"10.1039\u002Fc3ja30365a",{"id":18,"text":918,"url":18,"identifiers":919},"Hagendorfer H, Kaegi R, Traber J, Mertens SFL, Scherrers R, Ludwig C, et al. Application of an asymmetric flow field flow fractionation multi-detector approach for metallic engineered nanoparticle characterization – Prospects and limitations demonstrated on Au nanoparticles. Anal Chim Acta. 2011;706:367–78.",{"doi":920},"10.1016\u002Fj.aca.2011.08.014",{"id":18,"text":922,"url":18,"identifiers":923},"Schmidt B, Loescher K, Hadrup N, Mortens A, Sloth JJ, Bender Koch C, et al. Quantitative characterization of gold nanoparticles by field-flow fractionation coupled online with light scattering detection and inductively coupled plasma mass spectrometry. Anal Chem. 2011;83:2461–8.",{"doi":924},"10.1021\u002Fac102545e",{"id":18,"text":926,"url":18,"identifiers":927},"Williams SKR, Runyon JR, Ashames AA. Field-flow fractionation: addressing the nano challenge. Anal Chem. 2011;83:634–42.",{"doi":928},"10.1021\u002Fac101759z",{"id":18,"text":930,"url":18,"identifiers":931},"Kahraman MV, Bayramoğlu G, Kayaman-Apohan N, Güngör A. α-Amylase immobilization on functionalized glass beads by covalent attachment. Food Chem. 2007;104:1385–92.",{"doi":932},"10.1016\u002Fj.foodchem.2007.01.054",{"id":18,"text":934,"url":18,"identifiers":935},"Liu XD, Tokura S, Haruki M, Nishi N, Sakairi N. Surface modification of nonporous glass beads with chitosan and their adsorption property for transition metal ions. Carbohydr Polym. 2002;49:103–8.",{"doi":936},"10.1016\u002FS0144-8617(01)00308-3",{"id":18,"text":938,"url":18,"identifiers":939},"Cipriani G, Salvini A, Baglioni P, Bucciarelli B. Cellulose as a renewable resource for the synthesis of wood consolidants. J Appl Polym Sci. 2010;118:2939–50.",{"doi":940},"10.1002\u002Fapp.32634",{"id":18,"text":942,"url":18,"identifiers":943},"Stoyneva V, Momekova D, Kostova B, Petrov P. Stimuli sensitive super-macroporous cryogels based on photo-crosslinked 2-hydroxyethylcellulose and chitosan. Carbohydr Polym. 2014;99:825–30.",{"doi":944},"10.1016\u002Fj.carbpol.2013.08.095",{"id":18,"text":946,"url":18,"identifiers":947},"Wang X, Gao JZ, Yang W. Polymeric super absorbing composite prepared using a glow-discharge electrolysis plasma for the removal of divalent heavy metal ions from aqueous solutions and its swelling properties. Polymer Engineering Science. 2012;52:2217–27.",{"doi":948},"10.1002\u002Fpen.23170",{"id":18,"text":950,"url":18,"identifiers":951},"Guibal E. Heterogeneous catalysis on chitosan-based materials. Prog Polym Sci. 2005;30:71–109.",{"doi":952},"10.1016\u002Fj.progpolymsci.2004.12.001",{"id":18,"text":954,"url":18,"identifiers":955},"Jal PK, Patel S, Mishra BK. Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions. Talanta. 2004;62:1005–8.",{"doi":956},"10.1016\u002Fj.talanta.2003.10.028",{"id":18,"text":958,"url":18,"identifiers":959},"Shen C, Wang Y, Xu J, Luo G. Chitosan supported on porous glass beads as a new green adsorbent for heavy metal recovery. Chem Eng J. 2013;229:217–24.",{"doi":960},"10.1016\u002Fj.cej.2013.06.003",{"id":18,"text":962,"url":18,"identifiers":963},"Levard C, Hotze EM, Lowry GV, Brown GE. Environmental transformations of silver nanoparticles: impact on stability and toxicity environ. Science Technology. 2012;46:6900–14.",{"doi":964},"10.1021\u002Fes2037405",{"id":18,"text":966,"url":18,"identifiers":967},"El Badawy AM, Luxton TP, Silva RG, Scheckel KG, Suidan MT, Tolaymat TM. Impact of environmental conditions (pH, ionic strength, and electrolyte type) on the surface charge and aggregation of silver nanoparticles suspensions. Environ Sci Tech. 2010;44:1260–6.",{"doi":968},"10.1021\u002Fes902240k",{"id":18,"text":970,"url":18,"identifiers":971},"Yin YG, Liu J, Guibin J. Sunlight-induced reduction of ionic Ag and Au to metallic nanoparticles by dissolved organic matter. ACS Nano. 2012;6:7910–9.",{"doi":972},"10.1021\u002Fnn302293r",{"id":18,"text":974,"url":18,"identifiers":975},"Chao JB, Liu JF, Yu SJ, Feng YD, Tan ZQ, Liu R, et al. Speciation analysis of silver nanoparticles and silver ions in antibacterial products and environmental waters via cloud point extraction-based separation. Anal Chem. 2011;83:6875–82.",{"doi":976},"10.1021\u002Fac201086a",{"id":18,"text":978,"url":18,"identifiers":979},"Poda AR, Bednar AJ, Kennedy AJ, Harmon A, Hull M, Mitrano J, et al. Characterization of silver nanoparticles using flow-field flow fractionation interfaced to inductively coupled plasma mass spectrometry. J Chromatogr A. 2011;1218:4219–25.",{"doi":980},"10.1016\u002Fj.chroma.2010.12.076",{"id":18,"text":982,"url":18,"identifiers":983},"Soto-Alvaredo J, Montes-Bayón M, Bettmer J. Speciation of silver nanoparticles and silver(I) by reversed-phase liquid chromatography coupled to ICPMS. Anal Chem. 2013;85:1316–21.",{"doi":984},"10.1021\u002Fac302851d",{"id":18,"text":986,"url":18,"identifiers":987},"Tiede K, Boxal AB, Tear SP, Lewis J, David H, Hassellov M. Detection and characterization of engineered nanoparticles in food and the environment. Food, Additives and Contaminant. 2008;25:795–821.",{"doi":988},"10.1080\u002F02652030802007553",{"id":18,"text":990,"url":18,"identifiers":991},"Hassellöv M, Readman JW, Ranville JF, Tiede K. Nanoparticle analysis and characterization methodologies in environmental risk assessment of engineered nanoparticles. Ecotoxicology. 2008;17:344–61.",{"doi":992},"10.1007\u002Fs10646-008-0225-x",{"id":18,"text":994,"url":18,"identifiers":995},"Weast RC. CRC Handbook of Chemistry and Physics. 46th ed. Cleveland, Ohio: CRC Press; 1965.",{},{"id":997,"createTime":998,"updateTime":999,"relativeEntities":1000,"slug":1001,"properties":1002,"entityType":113,"verifyStatus":114,"verifyTime":1017,"verifyNote":115,"syncStatus":17,"languages":1018,"translateLanguages":18,"viewCount":19,"primaryUrl":1019,"fullTextUrl":18,"authors":1020,"publicationType":236,"publisherRelationship":1207,"citationCount":1227,"citationInfo":1228,"publishDate":1230,"publishYear":1231,"citationAnalyzeStatus":1232,"lastCitationAnalyze":1233,"indexDatabases":18,"openAccess":18,"references":1234,"isForceReanalyzing":264},"3e7bf1c7-de71-49fe-8711-a3234246a967","2024-04-13T17:16:54.651+00:00","2024-12-11T23:50:20.434+00:00",[],"Preparation-and-application-of-melamine-cross-linked-poly-ammonium-as-shale-inhibitor",{"mag":1003,"keywords":1005,"pmc":1006,"openalex":1008,"abstract":1010,"title":1011,"pm":1013,"doi":1015},{"VOID":1004},"2800379933",{},{"VOID":1007},"5915987",{"VOID":1009},"W2800379933",{},{"EN":1012},"Preparation and application of melamine cross-linked poly ammonium as shale inhibitor",{"VOID":1014},"29691725",{"VOID":1016},"10.1186\u002Fs13065-018-0410-9","2024-12-11T23:50:20.433+00:00",[287],"https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13065-018-0410-9",[1021,1040,1059,1076,1098,1112,1128,1146,1161,1175,1191],{"id":1022,"sortIndex":207,"researcher":18,"roles":1023,"affiliations":1024,"properties":1033},"32454075-eac0-4f58-b747-3906dedf862c",[],[1025],{"id":18,"sortIndex":19,"affiliation":1026,"properties":18},{"id":1027,"createTime":1028,"updateTime":1028,"relativeEntities":1029,"slug":18,"properties":1030,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"bb20a7c4-5e8f-46e7-aacf-e25626ca219f","2024-01-17T01:16:00.056+00:00",[],{"title":1031},{"VI":1032},"College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, Shaanxi, China",{"openalex":1034,"orcid":1036,"title":1038},{"VOID":1035},"A5080694348",{"VOID":1037},"https:\u002F\u002Forcid.org\u002F0000-0003-0664-5419",{"EN":1039},"Qiang Deng",{"id":1041,"sortIndex":138,"researcher":18,"roles":1042,"affiliations":1043,"properties":1054},"b5af97d5-e323-4cd7-9579-45b3d36fffd7",[],[1044],{"id":18,"sortIndex":19,"affiliation":1045,"properties":18},{"id":1046,"createTime":1047,"updateTime":1048,"relativeEntities":1049,"slug":1050,"properties":1051,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"18f5f418-28f5-4679-b567-6669579217fb","2024-01-05T12:04:15.007+00:00","2025-02-03T02:41:16.327+00:00",[],"School-of-Materials-Science-and-Engineering-Northwestern-Polytechnical-University-Xi-an-710072-China",{"title":1052},{"VI":1053},"School of Materials Science and Engineering, Northwestern Polytechnical University, Xi’an, 710072, China",{"openalex":1055,"title":1057},{"VOID":1056},"A5044609129",{"EN":1058},"Tiehu Li",{"id":1060,"sortIndex":1061,"researcher":18,"roles":1062,"affiliations":1063,"properties":1069},"b8025344-90c9-4c19-ba00-a2b0f24ffc89",8,[],[1064],{"id":18,"sortIndex":19,"affiliation":1065,"properties":18},{"id":1027,"createTime":1028,"updateTime":1028,"relativeEntities":1066,"slug":18,"properties":1067,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1068},{"VI":1032},{"openalex":1070,"orcid":1072,"title":1074},{"VOID":1071},"A5046439009",{"VOID":1073},"https:\u002F\u002Forcid.org\u002F0000-0002-3711-4250",{"EN":1075},"Gang Chen",{"id":1077,"sortIndex":1078,"researcher":18,"roles":1079,"affiliations":1080,"properties":1091},"bc368482-9091-4318-8d7e-a8648837f368",9,[],[1081],{"id":18,"sortIndex":19,"affiliation":1082,"properties":18},{"id":1083,"createTime":1084,"updateTime":1085,"relativeEntities":1086,"slug":1087,"properties":1088,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"54ef3c77-5026-47ff-937a-4b0594ce7840","2024-02-08T01:08:16.004+00:00","2024-09-03T07:54:43.305+00:00",[],"State-Key-Laboratory-of-Petroleum-Pollution-Control-CNPC-Research-Institute-of-Safety-and-Environmental-Technology-Beijing-102206-China",{"title":1089},{"VI":1090},"State Key Laboratory of Petroleum Pollution Control, CNPC Research Institute of Safety and Environmental Technology, Beijing 102206, China",{"openalex":1092,"orcid":1094,"title":1096},{"VOID":1093},"A5011289399",{"VOID":1095},"https:\u002F\u002Forcid.org\u002F0009-0003-1587-0957",{"EN":1097},"Jie Zhang",{"id":1099,"sortIndex":84,"researcher":18,"roles":1100,"affiliations":1101,"properties":1107},"50feb03e-7148-48e0-b6db-2fd29b3e7323",[],[1102],{"id":18,"sortIndex":19,"affiliation":1103,"properties":18},{"id":1027,"createTime":1028,"updateTime":1028,"relativeEntities":1104,"slug":18,"properties":1105,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1106},{"VI":1032},{"openalex":1108,"title":1110},{"VOID":1109},"A5077150149",{"EN":1111},"Yan Xiao",{"id":1113,"sortIndex":169,"researcher":18,"roles":1114,"affiliations":1115,"properties":1121},"4fe02c6f-60ee-4a8c-977d-334b26f1898d",[],[1116],{"id":18,"sortIndex":19,"affiliation":1117,"properties":18},{"id":1027,"createTime":1028,"updateTime":1028,"relativeEntities":1118,"slug":18,"properties":1119,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1120},{"VI":1032},{"openalex":1122,"orcid":1124,"title":1126},{"VOID":1123},"A5015367925",{"VOID":1125},"https:\u002F\u002Forcid.org\u002F0000-0001-5536-8564",{"EN":1127},"Lili Li",{"id":1129,"sortIndex":225,"researcher":18,"roles":1130,"affiliations":1131,"properties":1141},"f1df10cc-8668-4b86-925d-5a370d29cbe3",[],[1132],{"id":18,"sortIndex":19,"affiliation":1133,"properties":18},{"id":1134,"createTime":1135,"updateTime":1135,"relativeEntities":1136,"slug":1137,"properties":1138,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"fd324016-5ff0-404c-8e7f-c40684a6003a","2024-04-13T17:16:54.788+00:00",[],"Shaanxi-Province-Key-Laboratory-of-Environmental-Pollution-Control-and-Reservoir-Protection-Technology-of-Oilfields-Xi-an-710065-China",{"title":1139},{"EN":1140},"Shaanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, Xi'an, 710065, China",{"openalex":1142,"title":1144},{"VOID":1143},"A5059879271",{"EN":1145},"Zhongbin Ye",{"id":1147,"sortIndex":1148,"researcher":18,"roles":1149,"affiliations":1150,"properties":1156},"344ace7f-c34b-44f3-a905-f8d199d8f7df",10,[],[1151],{"id":18,"sortIndex":19,"affiliation":1152,"properties":18},{"id":1134,"createTime":1135,"updateTime":1135,"relativeEntities":1153,"slug":1137,"properties":1154,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1155},{"EN":1140},{"openalex":1157,"title":1159},{"VOID":1158},"A5065940864",{"EN":1160},"Zhifang Zhang",{"id":1162,"sortIndex":194,"researcher":18,"roles":1163,"affiliations":1164,"properties":1170},"6236b45b-5e7b-44f4-a02f-d5868e55f069",[],[1165],{"id":18,"sortIndex":19,"affiliation":1166,"properties":18},{"id":1134,"createTime":1135,"updateTime":1135,"relativeEntities":1167,"slug":1137,"properties":1168,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1169},{"EN":1140},{"openalex":1171,"title":1173},{"VOID":1172},"A5008473915",{"EN":1174},"Zhengqin Ye",{"id":1176,"sortIndex":120,"researcher":18,"roles":1177,"affiliations":1178,"properties":1184},"89fb6b23-ac13-4bbd-96dd-54d2d87c8171",[],[1179],{"id":18,"sortIndex":19,"affiliation":1180,"properties":18},{"id":1027,"createTime":1028,"updateTime":1028,"relativeEntities":1181,"slug":18,"properties":1182,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1183},{"VI":1032},{"openalex":1185,"orcid":1187,"title":1189},{"VOID":1186},"A5061765321",{"VOID":1188},"https:\u002F\u002Forcid.org\u002F0000-0003-0989-5392",{"EN":1190},"Huang Lei",{"id":1192,"sortIndex":19,"researcher":18,"roles":1193,"affiliations":1194,"properties":1200},"a7721c39-f8c4-4393-85a6-d6b9634780db",[],[1195],{"id":18,"sortIndex":19,"affiliation":1196,"properties":18},{"id":1046,"createTime":1047,"updateTime":1048,"relativeEntities":1197,"slug":1050,"properties":1198,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1199},{"VI":1053},{"openalex":1201,"orcid":1203,"title":1205},{"VOID":1202},"A5066716873",{"VOID":1204},"https:\u002F\u002Forcid.org\u002F0000-0002-9386-8938",{"EN":1206},"Li Zhang",{"url":18,"publisher":1208,"properties":18},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1209,"slug":10,"properties":1210,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1213,"manageAffiliations":1214,"indexDatabases":1215,"url":18,"thumbnailPath":18,"statistic":1222,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1211,"title":1212},{"VOID":13},{"EN":15},[],[],[1216],{"id":24,"indexDatabase":1217,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":1218,"label":1219,"description":1220,"key":34,"publicationTags":1221,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":1223,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":1224,"totalCitation":65,"totalCitationByYear":1225,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":1226,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},15,{"total":1227,"publishYear":18,"statisticByYear":1229},{"2019":225,"2020":138,"2021":120,"2022":169,"2023":138,"2024":138},"2018-12-01",2018,"ERROR_IN_ANALYZE_CITATION","2024-04-14T03:15:22.344+00:00",[1235,1239,1243,1247,1251,1255,1259,1262,1266,1269,1272,1276,1279,1282,1285,1288,1291,1294,1297,1301],{"id":18,"text":1236,"url":18,"identifiers":1237},"Retz RH, Friedheim J, Lee LJ, Welch OO (1991) An environmentally acceptable and field-practical, cationic polymer mud system. In: Paper SPE 23064, offshore Europe conference held in Aberdeen, 3–6 September",{"doi":1238},"10.2118\u002F23064-MS",{"id":18,"text":1240,"url":18,"identifiers":1241},"Sheu JJ, Perricone AC (1988) Design and synthesis of shale stabilizing polymers for water-based drilling fluids. In: Paper SPE 18033, annual technical conference and exhibition, Texas, 2–5 October",{"doi":1242},"10.2118\u002F18033-MS",{"id":18,"text":1244,"url":18,"identifiers":1245},"Stamatakis E, Thaemlitz CJ, Coffin G, Reid W (1995) A new generation of shale inhibitors for water-based muds. In: SPE\u002FIADC 29406, 1995 SPE\u002FIADC drilling conference held in Amsterdam, Amsterdam",{"doi":1246},"10.2118\u002F29406-MS",{"id":18,"text":1248,"url":18,"identifiers":1249},"Steiger RP, Leung PK (1992) Qualitative determination of the mechanical properties of shales. Paper SPE 18024. SPE Drill Eng 7(3):181",{"doi":1250},"10.2118\u002F18024-PA",{"id":18,"text":1252,"url":18,"identifiers":1253},"Oort Van (2003) On the physical and chemical stability of shales. J Petrol Sci Eng 38:213–235",{"doi":1254},"10.1016\u002FS0920-4105(03)00034-2",{"id":18,"text":1256,"url":18,"identifiers":1257},"Patel A.D., 2009. Design and development of quaternary amine compounds: shale inhibition with improved environmental profile. In: Paper SPE 121737, international symposium on oilfield chemistry, p 20",{"doi":1258},"10.2118\u002F121737-MS",{"id":18,"text":1260,"url":18,"identifiers":1261},"Doonechaly NG, Tahmasbi K, Davani E (2009) Development of high-performance water-based mud formulation based on amine derivatives. In: Paper SPE 121228, presented at international symposium on oilfield chemistry, p 21",{},{"id":18,"text":1263,"url":18,"identifiers":1264},"Qu YZ, Lai XQ, Zou LF, Su YN (2009) Polyoxyalkyleneamine as shale inhibitor in water-based drilling fluids. Appl Clay Sci 44:264–265",{"doi":1265},"10.1016\u002Fj.clay.2009.03.003",{"id":18,"text":1267,"url":18,"identifiers":1268},"Wang JH, Yan JN, Ding TW (2007) Progresses in the researches on high performance water base muds. Drill Fluid Complet Fluid 1:1–2",{},{"id":18,"text":1270,"url":18,"identifiers":1271},"Zhang KQ, He L, An SF (2007) An introduction to the high performance water base muds abroad. Drill Fluid Complet Fluid 3:1–3",{},{"id":18,"text":1273,"url":18,"identifiers":1274},"Amanullah M (2007) Screening and evaluation of some environment-friendly mud additives to use in water-based drilling muds. In: Paper SPE 98054 E&P environmental and safety conference, p 6",{"doi":1275},"10.2523\u002F98054-MS",{"id":18,"text":1277,"url":18,"identifiers":1278},"Gao BY, Sun X, Yue QY, Zhang DH, Lu L, Wang XN, Wang Y (2006) The structure of epichlorohydrin-diethylamine polymer flocculants with different modifying agents and their properties for decoloration of wastewater. Acta Sci Circ 26:1977–1982",{},{"id":18,"text":1280,"url":18,"identifiers":1281},"Shang YG, Jiang SL, Di L (2010) Study on synthesis and clay stabilizer properties of poly epichlorohydrin-diethylamine. Guangdong Chem Ind 37:59–61",{},{"id":18,"text":1283,"url":18,"identifiers":1284},"Cai D, Zhang J, Chen G (2014) Study on the effect of carboxy-amines small molecule shale inhibitor. Oilfield Chem 31:5–8",{},{"id":18,"text":1286,"url":18,"identifiers":1287},"Zhang J, Zhang Q, Chen G (2013) Mechanism study and application of modified polysaccharides as drilling fluid additive with high inhabitability. Tech Dev Chem Ind 42:1–5",{},{"id":18,"text":1289,"url":18,"identifiers":1290},"Zhang J, Cai D, Chen G (2014) Performance assessment of a polyamine swelling inhibitor for clays and shales. Nat Gas Ind 34:85–90",{},{"id":18,"text":1292,"url":18,"identifiers":1293},"Fu ML, Chen G, Tang SF, Wen SC (2015) Principle of oilfield chemistry. Petroleum Industry Press, Beijing",{},{"id":18,"text":1295,"url":18,"identifiers":1296},"GB\u002FT 16783.1-2006 Petroleum and natural gas industries for field testing of drilling fluids",{},{"id":18,"text":1298,"url":18,"identifiers":1299},"Xi YF, Ding Z, He H, Frost RL (2004) Structure of organoclays—an X-ray diffraction and thermogravimetric analysis study. J Colloid Interface Sci 277:116–120",{"doi":1300},"10.1016\u002Fj.jcis.2004.04.053",{"id":18,"text":1302,"url":18,"identifiers":1303},"Qiu ZS, Zhong HY, Huang WA (2011) Properties and mechanism of a new polyamine shale inhibitor. Acta Petrolei Sinica 32:678–682",{},{"id":1305,"createTime":1306,"updateTime":1307,"relativeEntities":1308,"slug":1309,"properties":1310,"entityType":113,"verifyStatus":114,"verifyTime":1307,"verifyNote":115,"syncStatus":17,"languages":1326,"translateLanguages":18,"viewCount":19,"primaryUrl":1327,"fullTextUrl":18,"authors":1328,"publicationType":236,"publisherRelationship":1417,"citationCount":76,"citationInfo":1437,"publishDate":1439,"publishYear":743,"citationAnalyzeStatus":1232,"lastCitationAnalyze":1440,"indexDatabases":18,"openAccess":18,"references":1441,"isForceReanalyzing":264},"f903fcc2-7391-4634-a917-9ba49efa19db","2024-04-13T19:29:29.668+00:00","2025-02-06T23:49:26.644+00:00",[],"Bioaccumulative-and-conchological-assessment-of-heavy-metal-transfer-in-a-soil-plant-snail-food-chain",{"mag":1311,"keywords":1313,"pmc":1314,"openalex":1316,"abstract":1318,"title":1320,"pm":1322,"doi":1324},{"VOID":1312},"2158031650",{},{"VOID":1315},"3472253",{"VOID":1317},"W2158031650",{"EN":1319},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) can pose serious threats to environmental health because they tend to bioaccumulate in terrestrial ecosystems. We investigated under field conditions the transfer of these heavy metals in a soil-plant-snail food chain in Banat area, Romania. The main goal of this paper was to assess the Roman snail (\u003Cjats:italic>Helix pomatia\u003C\u002Fjats:italic>) usefulness in environmental monitoring as bioindicator of heavy metal accumulation. Eight sampling sites, selected by different history of heavy metal (HM) exposure, were chosen to be sampled for soil, nettle leaves, and newly matured snails. This study also aimed to identify the putative effects of HM accumulation in the environment on phenotypic variability in selected shell features, which included shell height (SH), relative shell height (RSH), and whorl number (WN).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>Significantly higher amounts of HMs were accumulated in snail hepatopancreas and not in foot. Cu, Zn, and Cd have biomagnified in the snail body, particularly in the hepatopancreas. In contrast, Pb decreased when going up into the food chain. Zn, Cd, and Pb correlated highly with each other at all levels of the investigated food chain. Zn and Pb exhibited an effective soil–plant transfer, whereas in the snail body only foot Cu concentration was correlated with that in soil. There were significant differences among sampling sites for WN, SH, and RSH when compared with reference snails. WN was strongly correlated with Cd and Pb concentrations in nettle leaves but not with Cu and Zn. SH was independent of HM concentrations in soil, snail hepatopancreas, and foot. However, SH correlated negatively with nettle leaves concentrations for each HM except Cu. In contrast, RSH correlated significantly only with Pb concentration in hepatopancreas.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n            \u003Cjats:p>The snail hepatopancreas accumulates high amounts of HMs, and therefore, this organ can function as a reliable biomarker for tracking HM bioavailability in soil. Long-term exposure to HMs via contaminated food might influence the variability of shell traits in snail populations. Therefore, our results highlight the Roman snail (\u003Cjats:italic>Helix pomatia\u003C\u002Fjats:italic>) potential to be used in environmental monitoring studies as bioindicator of HM pollution.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":1321},"Bioaccumulative and conchological assessment of heavy metal transfer in a soil-plant-snail food chain",{"VOID":1323},"22703871",{"VOID":1325},"10.1186\u002F1752-153x-6-55",[287],"https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-153X-6-55",[1329,1349,1365,1383,1401],{"id":1330,"sortIndex":120,"researcher":18,"roles":1331,"affiliations":1332,"properties":1342},"2e824ca2-d4af-413c-a280-297de8f24584",[],[1333],{"id":18,"sortIndex":19,"affiliation":1334,"properties":18},{"id":1335,"createTime":1336,"updateTime":1336,"relativeEntities":1337,"slug":1338,"properties":1339,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"79b425b7-f6c6-4724-853f-926bb24d4f94","2024-04-13T19:29:29.718+00:00",[],"Banat-s-University-of-Agricultural-Sciences-and-Veterinary-Medicine-from-Timisoara-Faculty-of-Food-Processing-Technology-Calea-Aradului-119-RO-300645-Timisoara-Romania",{"title":1340},{"EN":1341},"Banat's University of Agricultural Sciences and Veterinary Medicine from Timisoara, Faculty of Food Processing Technology, Calea Aradului 119, RO, 300645, Timisoara, Romania",{"openalex":1343,"orcid":1345,"title":1347},{"VOID":1344},"A5068053673",{"VOID":1346},"https:\u002F\u002Forcid.org\u002F0000-0002-8144-1961",{"EN":1348},"I. Gergen",{"id":1350,"sortIndex":225,"researcher":18,"roles":1351,"affiliations":1352,"properties":1358},"c1b2cf19-9301-41be-aa25-e12b5351277b",[],[1353],{"id":18,"sortIndex":19,"affiliation":1354,"properties":18},{"id":1335,"createTime":1336,"updateTime":1336,"relativeEntities":1355,"slug":1338,"properties":1356,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1357},{"EN":1341},{"openalex":1359,"orcid":1361,"title":1363},{"VOID":1360},"A5081277351",{"VOID":1362},"https:\u002F\u002Forcid.org\u002F0000-0002-1647-7992",{"EN":1364},"Despina-Maria Bordean",{"id":1366,"sortIndex":19,"researcher":18,"roles":1367,"affiliations":1368,"properties":1378},"70331d51-3135-43e6-8e20-bb9a7ec7afdc",[],[1369],{"id":18,"sortIndex":19,"affiliation":1370,"properties":18},{"id":1371,"createTime":1372,"updateTime":1372,"relativeEntities":1373,"slug":1374,"properties":1375,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"7e8ed6d9-dd99-44fb-a984-bf790036cd36","2024-04-13T19:29:29.686+00:00",[],"Banat-s-University-of-Agricultural-Sciences-and-Veterinary-Medicine-from-Timisoara-Faculty-of-Animal-Sciences-and-Biotechnologies-Timisoara-Calea-Aradului-119-RO-300645-Romania",{"title":1376},{"EN":1377},"Banat's University of Agricultural Sciences and Veterinary Medicine from Timisoara, Faculty of Animal Sciences and Biotechnologies, Timisoara, Calea Aradului 119, RO, 300645, Romania",{"openalex":1379,"title":1381},{"VOID":1380},"A5068576782",{"EN":1382},"Dragoş Nica",{"id":1384,"sortIndex":194,"researcher":18,"roles":1385,"affiliations":1386,"properties":1396},"ae58283a-6867-403d-beba-8c9097e47e65",[],[1387],{"id":18,"sortIndex":19,"affiliation":1388,"properties":18},{"id":1389,"createTime":1390,"updateTime":1390,"relativeEntities":1391,"slug":1392,"properties":1393,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"cf22404e-dfc9-426a-b08c-54f34af83869","2024-04-11T19:22:49.165+00:00",[],"Banat-s-University-of-Agricultural-Sciences-and-Veterinary-Medicine-from-Timisoara-Faculty-of-Agriculture-Timisoara-RO-300645-Calea-Aradului-119-Romania",{"title":1394},{"EN":1395},"Banat’s University of Agricultural Sciences and Veterinary Medicine from Timisoara, Faculty of Agriculture, Timisoara, RO, 300645, Calea Aradului 119, Romania",{"openalex":1397,"title":1399},{"VOID":1398},"A5012243789",{"EN":1400},"Monica Hărmănescu",{"id":1402,"sortIndex":138,"researcher":18,"roles":1403,"affiliations":1404,"properties":1410},"d8fd08ac-1ba6-4506-b796-fd3d99c736d5",[],[1405],{"id":18,"sortIndex":19,"affiliation":1406,"properties":18},{"id":1371,"createTime":1372,"updateTime":1372,"relativeEntities":1407,"slug":1374,"properties":1408,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1409},{"EN":1377},{"openalex":1411,"orcid":1413,"title":1415},{"VOID":1412},"A5042361620",{"VOID":1414},"https:\u002F\u002Forcid.org\u002F0000-0001-7259-204X",{"EN":1416},"Marian Bura",{"url":18,"publisher":1418,"properties":18},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1419,"slug":10,"properties":1420,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1423,"manageAffiliations":1424,"indexDatabases":1425,"url":18,"thumbnailPath":18,"statistic":1432,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1421,"title":1422},{"VOID":13},{"EN":15},[],[],[1426],{"id":24,"indexDatabase":1427,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":1428,"label":1429,"description":1430,"key":34,"publicationTags":1431,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":1433,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":1434,"totalCitation":65,"totalCitationByYear":1435,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":1436,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"total":76,"publishYear":18,"statisticByYear":1438},{"2012":120,"2013":1061,"2014":194,"2015":84,"2016":1061,"2017":138,"2018":225,"2019":169,"2020":169,"2021":1061,"2022":169,"2023":225,"2024":194},"2012-12-01","2024-04-14T05:47:20.562+00:00",[1442,1446,1449,1453,1457,1460,1463,1467,1471,1475,1478,1481,1485,1488,1491,1494,1498,1501,1505,1508,1512,1516,1520,1524,1528,1532,1536,1540,1544,1547,1550,1553,1557,1561,1564,1568,1571,1575,1579,1583,1587,1591,1594,1598,1601,1604,1608,1612,1616,1620,1624,1627,1630,1633,1636,1639,1642,1645],{"id":18,"text":1443,"url":18,"identifiers":1444},"Lovett GM, Burns DA, Driscoll CT, Jenkins JC, Mitchell MJ, Rustad L, Shanley JE, Likens GE, Haeuber R: Who needs environmental monitoring?. Front Ecol Environ. 2007, 5: 253-260. 10.1890\u002F1540-9295(2007)5[253:WNEM]2.0.CO;2.",{"doi":1445},"10.1890\u002F1540-9295(2007)5[253:WNEM]2.0.CO;2",{"id":18,"text":1447,"url":18,"identifiers":1448},"Wharfe J: Hazardous chemicals in complex mixtures – a role for direct toxicity assessment. Ecotoxicology. 2004, 13: 81-88.",{},{"id":18,"text":1450,"url":18,"identifiers":1451},"Murariu M, Dragan ES, Drochioiu G: Electrospray ionization mass spectrometric approach of conformationally-induced metal binding to oligopeptides. Eur J Mass Spectrom. 2010, 16: 511-521. 10.1255\u002Fejms.1092.",{"doi":1452},"10.1255\u002Fejms.1092",{"id":18,"text":1454,"url":18,"identifiers":1455},"Sillins I, Hogberg J: Combined toxic exposures and human health: biomarkers of exposure and effect. Int J Environ Res Public Health. 2011, 8: 629-647. 10.3390\u002Fijerph8030629.",{"doi":1456},"10.3390\u002Fijerph8030629",{"id":18,"text":1458,"url":18,"identifiers":1459},"Agarwal SK: Heavy metal pollution. 2009, New Delhi: APH Publishing Corporation, 1-89.",{},{"id":18,"text":1461,"url":18,"identifiers":1462},"Ryu H, Chung JS, Nam T, Moon HS, Nam K: Incorporation of heavy metals bioavailability into risk characterization. Clean. 2010, 38: 812-815.",{},{"id":18,"text":1464,"url":18,"identifiers":1465},"Tomasik P, Magadza CM, Mhinz AS, Chirume A, Zaranyika MF, Muchiriri S: The metal-metal interaction in biological systems. Part IV. Freshwater snail Bulinus globosus. Water Air Soil Pollut. 1995, 83: 123-145. 10.1007\u002FBF00482599.",{"doi":1466},"10.1007\u002FBF00482599",{"id":18,"text":1468,"url":18,"identifiers":1469},"Ren S, Mee RW, Frymier PD: Using factorial experiments to study the toxicity of metal mixtures. Ecotoxicol Environ Saf. 2004, 59: 38-43. 10.1016\u002FS0147-6513(03)00099-X.",{"doi":1470},"10.1016\u002FS0147-6513(03)00099-X",{"id":18,"text":1472,"url":18,"identifiers":1473},"Maynard R: Key airborne pollutants - the impact on health. Sci Total Environ. 2004, 334–335: 9-13.",{"doi":1474},"10.1016\u002Fj.scitotenv.2004.04.025",{"id":18,"text":1476,"url":18,"identifiers":1477},"MWFEP(Romania Ministry of Waters, Forests and Environmental Protection): Ordinul nr. 756\u002F1997 al Ministerului Apelor, Padurilor şi Protecţiei Mediului pentru aprobarea Reglementării privind evaluarea poluarii mediului modificat de Ordinul nr. 1144, [http:\u002F\u002Fwww.unimed.ro\u002FOrdin%20nr.%201144-2002.pdf], \u002F2002 al Ministerului Apelor şi Protecţei Mediului,",{},{"id":18,"text":1479,"url":18,"identifiers":1480},"Moigradean D, Lazureanu A, Poiana MA, Harmanescu M, Gogoasa I, Gergen I: The influence of mineral fertilization about nitrogen content in soil, plant and tomato fruit. Bull Univ Agric Sci Vet Med Cluj-Napoca Horti. 2008, 65: 172-177.",{},{"id":18,"text":1482,"url":18,"identifiers":1483},"Schlosser G, Stefanescu R, Przybylski M, Murariu M, Hudecz F, Drochioiu G: Copper-induced oligomerization of peptides: a model study. Eur J Mass Spectrom. 2007, 13 (5): 331-337.",{"doi":1484},"10.1255\u002Fejms.889",{"id":18,"text":1486,"url":18,"identifiers":1487},"Peralta JR, Gardea-Torresdey JL, Tiemann KJ, Gomez E, Arteaga S, Rascon E, Parsons JG: Uptake and effects of five heavy metals on seed germination and plant growth in Alfalfa(Medicago sativa L.). Environ Contam Toxicol. 2001, 66: 727-734.",{},{"id":18,"text":1489,"url":18,"identifiers":1490},"Emsley J: Nature's building blocks: an A-Z guide to the elements. 2001, Oxford: Oxford University Press",{},{"id":18,"text":1492,"url":18,"identifiers":1493},"Nordberg GF, Sanstrom B, Becking G, Goyer RA: Esentiality and toxicity of metals. Heavy metals in the environment. Edited by: Sarkar B. 2002, New York: Marcel Decker, Inc, 1-31.",{},{"id":18,"text":1495,"url":18,"identifiers":1496},"Lane TW, Saito MA, George GN, Pickering IJ, Prince RC, Morel FMM: A cadmium enzyme from a marine diatom. Nature. 2005, 435: 42-44.",{"doi":1497},"10.1038\u002F435042a",{"id":18,"text":1499,"url":18,"identifiers":1500},"Hillinger N, Olaru M, Turnock D: The role of industrial archaeology in conservation: the Reşiţa area of the Romanian Carpathians. GeoJournal. 2003, 55: 607-630.",{},{"id":18,"text":1502,"url":18,"identifiers":1503},"Harmanescu M, Alda L, Bordean D, Gogoasa I, Gergen I: Heavy metals health risk assessment for population via consumption of vegetables grown in old mining area; a case study: Banat County, Romania. Chem Cent J. 2011, 5: 64-10.1186\u002F1752-153X-5-64.",{"doi":1504},"10.1186\u002F1752-153X-5-64",{"id":18,"text":1506,"url":18,"identifiers":1507},"Bordean D-M, Gergen I, Pîrvu D, Gogoasa I, Pirvulescu L: Studies concerning heavy metal pollution in Banat area. Bul USAMV-CN. 2006, 62:",{},{"id":18,"text":1509,"url":18,"identifiers":1510},"Laskowski R, Hopkin SP: Accumulation of Zn, Cu, Pb and Cd in the garden snail (Helix aspersa): implications for predators. Environ Pollut. 1996, 91: 289-297. 10.1016\u002F0269-7491(95)00070-4.",{"doi":1511},"10.1016\u002F0269-7491(95)00070-4",{"id":18,"text":1513,"url":18,"identifiers":1514},"Beeby A, Richmond L: Do the soft tissues of Helix aspersa serve as a quantitative sentinel of predicted free lead concentrations in soil?. Appl Soil Ecol. 2003, 22: 159-165. 10.1016\u002FS0929-1393(02)00130-0.",{"doi":1515},"10.1016\u002FS0929-1393(02)00130-0",{"id":18,"text":1517,"url":18,"identifiers":1518},"Notten MJ, Oosthoek AJ, Rozema J, Aerts R: Heavy metal concentrations in a soil-plant-snail food chain along a terrestrial soil pollution gradient. Environ Pollut. 2005, 138: 178-190. 10.1016\u002Fj.envpol.2005.01.011.",{"doi":1519},"10.1016\u002Fj.envpol.2005.01.011",{"id":18,"text":1521,"url":18,"identifiers":1522},"Dallinger R, Chabicovsky M, Hodl E, Prem C, Hunziker P, Manzl C: Copper in Helix pomatia(Gastropoda) is regulated by one single cell type: differently responsive metal pools in rhogocytes. Am J Physiol Regul Integr Comp Physiol. 2005, 289: R1185-R1195. 10.1152\u002Fajpregu.00052.2005.",{"doi":1523},"10.1152\u002Fajpregu.00052.2005",{"id":18,"text":1525,"url":18,"identifiers":1526},"Mulvey M, Newman MC, Beeby AN: Genetic and conchological comparison of snails (Helix aspersa) differing in shell deposition of lead. J Molluscan Stud. 1996, 62: 213-223. 10.1093\u002Fmollus\u002F62.2.213.",{"doi":1527},"10.1093\u002Fmollus\u002F62.2.213",{"id":18,"text":1529,"url":18,"identifiers":1530},"Beeby A, Richmond L, Herpe F: Lead reduces shell mass in juvenile garden snails (Helix aspersa). Environ Pollut. 2002, 120: 283-288. 10.1016\u002FS0269-7491(02)00151-3.",{"doi":1531},"10.1016\u002FS0269-7491(02)00151-3",{"id":18,"text":1533,"url":18,"identifiers":1534},"Jordaens K, De Wolf H, Vandecasteele B, Blust R, Backeljau T: Associations between shell strength, shell morphology and heavy metals in the land snail Cepaea nemoralis (Gastropoda, Helicidae). Sci Total Environ. 2006, 363: 285-293. 10.1016\u002Fj.scitotenv.2005.12.002.",{"doi":1535},"10.1016\u002Fj.scitotenv.2005.12.002",{"id":18,"text":1537,"url":18,"identifiers":1538},"Viard B, Pihan F, Promeyrat S, Pihan J-C: Integrated assessment of heavy metal (Pb, Zn, Cd) highway pollution: bioaccumulation in soil, Graminaceae and land snails. Chemosphere. 2004, 55: 1349-1359. 10.1016\u002Fj.chemosphere.2004.01.003.",{"doi":1539},"10.1016\u002Fj.chemosphere.2004.01.003",{"id":18,"text":1541,"url":18,"identifiers":1542},"Gomot de Vaufleury A: Standardized growth toxicity testing (Cu, Zn, Pb, and Pentachloro phenol) with Helix aspersa. Ecotoxicol Environ Saf. 2000, 46: 41-50. 10.1006\u002Feesa.1999.1872.",{"doi":1543},"10.1006\u002Feesa.1999.1872",{"id":18,"text":1545,"url":18,"identifiers":1546},"Nemes N, Nemes N, Constantinescu L: Geogen pollution with heavy metals in Bistra area, Caras-Severin county. RJAS. 2007, 2: 69-73.",{},{"id":18,"text":1548,"url":18,"identifiers":1549},"Gogoasa I, Gergen I, Oprea G, Bordean D, Alda L, Moigradean D, Rada M, Bragea M: Preliminary research concerning the distribution of copper in the soil and vegetables in historical anthropic pollution(Caras-Severin County, Romania). J Agroaliment Process Technol. 2011, 17: 371-374.",{},{"id":18,"text":1551,"url":18,"identifiers":1552},"Gheoca V, Gheoca D: The accumulation of heavy metals in the tissues of Helix pomatia from locations with industrial and town pollution. Transylvanian Rev Syst Ecol Res. 2005, 2: 67-74.",{},{"id":18,"text":1554,"url":18,"identifiers":1555},"Hobbelen PHF, Koolhaas JC, Van Gestel CAM: Risk assessment of heavy metal pollution for detritivores in floodplain soils in the Biesbosch, The Netherlands, taking bioavailability into account. Environ Pollut. 2004, 129: 409-419. 10.1016\u002Fj.envpol.2003.11.010.",{"doi":1556},"10.1016\u002Fj.envpol.2003.11.010",{"id":18,"text":1558,"url":18,"identifiers":1559},"Suciu I, Cosma C, Todica M, Bolboaca SD, Jantschi L: Analysis of soil heavy metal pollution and pattern in Central Transylvania. Int J Mol Sci. 2008, 9 (4): 434-453. 10.3390\u002Fijms9040434.",{"doi":1560},"10.3390\u002Fijms9040434",{"id":18,"text":1562,"url":18,"identifiers":1563},"Bordean D-M, Dragomirescu M, Nicula M, Butnariu M, Goian I, Gergen I: Study of lead and cadmium content in soil, water and plants in Freidorf areea. Lucrări Stiintifice: Zootehnie si Biotehnologii. 2004, 37: 37-40.",{},{"id":18,"text":1565,"url":18,"identifiers":1566},"Kabata-Pendias A: Soil-plant transfer of trace elements: an environmental issue. Geoderma. 2004, 122: 143-149. 10.1016\u002Fj.geoderma.2004.01.004.",{"doi":1567},"10.1016\u002Fj.geoderma.2004.01.004",{"id":18,"text":1569,"url":18,"identifiers":1570},"Ianos G: Conclusions concerning the source and the environment concentration with heavy metals on the etno-historical Banat. Metal Elements in Environment, Medicine and Biology 2008. Tome VIII. 2end edition. Edited by: Silaghi-Dumitrescu I, Garban Z, Dragan P. 2008, Timisoara: Publishing House “Eurobit”, 205-223.",{},{"id":18,"text":1572,"url":18,"identifiers":1573},"Dallinger R, Berger B, Triebskorn-Kohler R, Kohler H: Soil biology and ecotoxicology. The biology of terrestrial molluscs. Edited by: Barker GM. 2001, Wallingford: CABI Publishing, 489-525.",{"doi":1574},"10.1079\u002F9780851993188.0489",{"id":18,"text":1576,"url":18,"identifiers":1577},"Rabitsch WB: Metal accumulation in terrestrial pulmonates at a lead\u002Fzinc smelter site in Arnoldstein, Austria. Bull Environ Contam Toxicol. 1996, 56: 734-741. 10.1007\u002Fs001289900108.",{"doi":1578},"10.1007\u002Fs001289900108",{"id":18,"text":1580,"url":18,"identifiers":1581},"Menta C, Parisi V: Metal concentrations in Helix pomatia, Helix aspersa and Arion rufus: a comparative study. Environ Pollut. 2001, 115: 205-208. 10.1016\u002FS0269-7491(01)00110-5.",{"doi":1582},"10.1016\u002FS0269-7491(01)00110-5",{"id":18,"text":1584,"url":18,"identifiers":1585},"Gomot de Vaufleury A, Coeurdassier M, Pandard P, Scheifler R, Lovy C, Crini N, Badot PM: How terrestrial snails can be used in risk assessment of soils. Environ Toxicol Chem. 2006, 25: 797-806. 10.1897\u002F04-560R.1.",{"doi":1586},"10.1897\u002F04-560R.1",{"id":18,"text":1588,"url":18,"identifiers":1589},"Moser H, Wieser W: Copper and nutrition in Helix pomatia (L.). Oecologia. 1979, 42: 241-251. 10.1007\u002FBF00344860.",{"doi":1590},"10.1007\u002FBF00344860",{"id":18,"text":1592,"url":18,"identifiers":1593},"Nica D, Filimon MN, Borozan AB, Vintila D: Can the environment induce intra-variety changes of Helix pomatia conchological features?. An UO Fasc Biol. 2011, 18: 140-145.",{},{"id":18,"text":1595,"url":18,"identifiers":1596},"Locher R, Baur B: Sperm delivery and egg production of the simultaneously hermaphroditic land snail Arianta arbustorum exposed to an increased sperm competition risk. Invertebr Reprod Dev. 2000, 38: 53-60. 10.1080\u002F07924259.2000.9652436.",{"doi":1597},"10.1080\u002F07924259.2000.9652436",{"id":18,"text":1599,"url":18,"identifiers":1600},"Orstan A: A method to measure shell volumes. Triton. 2011, 23: 31-32.",{},{"id":18,"text":1602,"url":18,"identifiers":1603},"Tryjanowski P, Koralewska-Batura E: Inter-habitat shell morphometric differentiation of the snail Helix lutescens Rossm. (Gastropoda: Pulmonata). Ekológia (Bratislava). 2002, 19: 11-116.",{},{"id":18,"text":1605,"url":18,"identifiers":1606},"Eeva T, Rainio K, Suominen O: Effects of pollution on land snail abundance, size and diversity as resources for pied flycatcher, Ficedula hypoleuca. Sci Total Environ. 2010, 408 (19): 4165-4169. 10.1016\u002Fj.scitotenv.2010.05.028.",{"doi":1607},"10.1016\u002Fj.scitotenv.2010.05.028",{"id":18,"text":1609,"url":18,"identifiers":1610},"Goodfriend GA: Variation in land snail shell form and size and its causes, a review. Syst Zool. 1986, 35: 204-223. 10.2307\u002F2413431.",{"doi":1611},"10.2307\u002F2413431",{"id":18,"text":1613,"url":18,"identifiers":1614},"Chiba S: Morphological divergence as a result of common adaptation to a shared environment in land snails of the genus Hirasea. J Molluscan Stud. 2009, 75: 253-259. 10.1093\u002Fmollus\u002Feyp020.",{"doi":1615},"10.1093\u002Fmollus\u002Feyp020",{"id":18,"text":1617,"url":18,"identifiers":1618},"Madec L, Bellido A, Guiller A: Shell shape of the land snail Cornu aspersum in North Africa, unexpected evidence of a phylogeographical splitting. Heredity. 2003, 91: 224-231. 10.1038\u002Fsj.hdy.6800301.",{"doi":1619},"10.1038\u002Fsj.hdy.6800301",{"id":18,"text":1621,"url":18,"identifiers":1622},"Beeby A, Richmond L: Magnesium and the deposition of lead in the shell of three populations of the garden snail Cantareus aspersus. Environ Pollut. 2011, 159: 1667-1672. 10.1016\u002Fj.envpol.2011.02.040.",{"doi":1623},"10.1016\u002Fj.envpol.2011.02.040",{"id":18,"text":1625,"url":18,"identifiers":1626},"Hopkins SP: In situ biological monitoring of pollution in terrestrial and aquatic ecosystems. Handbook of ecotoxicology Volume 1. Edited by: Calow P. 1993, Blackwell Scientific, 397-427.",{},{"id":18,"text":1628,"url":18,"identifiers":1629},"Bura M: Cresterea melcilor o activitate profitabila. 2004, Timişoara: Ed. Eurobit",{},{"id":18,"text":1631,"url":18,"identifiers":1632},"Baur B: Microgeographical variation in shell size of the land snail Chondrina clienta. Biol J Linn Soc. 1988, 37: 137-155.",{},{"id":18,"text":1634,"url":18,"identifiers":1635},"Grossu AV: Fauna R.P.R., Mollusca Gastropoda Pulmonata. 1955, Bucuresti: Editura Academiei R.P.R",{},{"id":18,"text":1637,"url":18,"identifiers":1638},"Borza I, Tarau D, Sala F, Tarau F, Iordache M: Quality state of soils from West of Romania and measures for their fertility restoration. RJAS. 2007, 39: 161-166.",{},{"id":18,"text":1640,"url":18,"identifiers":1641},"Kerney MP, Cameron RAD: A field guide to the land snails of Britain and northwestern Europe. 1979, London: Collins",{},{"id":18,"text":1643,"url":18,"identifiers":1644},"Statistica 10: http:\u002F\u002Fwww.statsoft.com\u002Fproducts\u002Fstatistica-10-new-features\u002F,",{},{"id":18,"text":1646,"url":18,"identifiers":1647},"Hammer R, Harper DAT, Ryan PD: Past: paleontological statistics software package for education and data analysis. Palaeontol Electron. 2001, 4 (1): 9-http:\u002F\u002Fpalaeo-electronica.org\u002F2001_1\u002Fpast\u002Fissue1_01.htm,",{},{"id":1649,"createTime":1650,"updateTime":1650,"relativeEntities":1651,"slug":18,"properties":1652,"entityType":113,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1661,"fullTextUrl":18,"authors":1662,"publicationType":236,"publisherRelationship":1702,"citationCount":18,"citationInfo":18,"publishDate":1727,"publishYear":1728,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":264},"410449c8-879d-49e9-b7af-6f169d95d7c8","2024-01-19T23:40:35.467+00:00",[],{"references":1653,"abstract":1655,"title":1657,"doi":1659},{"VOID":1654},"Dai J, Chen D, Jones RA, Hurley LH, Yang D: NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. Nucleic Acids Res. 2006, 34: 5133-5144.\nDai J, Dexheimer TS, Chen D, Carver M, Ambrus A, Jones RA, Yang D: An intramolecular G-quadruplex structure with mixed parallel\u002Fantiparallel G-strands formed in the human BCL-2 promoter region in solution. J Am Chem Soc. 2006, 128: 1096-1098.\nDexheimer TS, Sun D, Hurley LH: Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. J Am Chem Soc. 2006, 128: 5404-5415.\nHuppert JL, Balasubramanian S: G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res. 2007, 35: 406-413.\nYoung RL, Korsmeyer SJ: A negative regulatory element in the bcl-2 5’-untranslated region inhibits expression from an upstream promoter. Mol Cell Biol. 1993, 13: 3686-3697.\nClem RJ, Cheng EH, Karp CL, Kirsch DG, Ueno K, Takahashi A, Kastan MB, Griffin DE, Earnshaw WC, Veliuona MA, Hardwick JM: Modulation of cell death by Bcl-XL through caspase interaction. Proc Natl Acad Sci U S A. 1998, 95: 554-559.\nCristofanon S, Nuccitelli S, D’Alessio M, Radogna F, De Nicola M, Bergamaschi A, Cerella C, Magrini A, Diederich M, Ghibelli L: Oxidative upregulation of Bcl-2 in healthy lymphocytes. Ann N Y Acad Sci. 2006, 1091: 1-9.\nHaddad JJ: On the antioxidant mechanisms of Bcl-2: a retrospective of NF-kappaB signaling and oxidative stress. Biochem Biophys Res Commun. 2004, 322: 355-363.\nRaghavan SC, Swanson PC, Wu X, Hsieh CL, Lieber MR: A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature. 2004, 428: 88-93.\nTravascio P, Li Y, Sen D: DNA-enhanced peroxidase activity of a DNA-aptamer-hemin complex. Chem Biol. 1998, 5: 505-517.\nMergny JL, Li J, Lacroix L, Amrane S, Chaires JB: Thermal difference spectra: a specific signature for nucleic acid structures. Nucleic Acids Res. 2005, 33: e138-\nMergny JL, Lacroix L: UV Melting of G-Quadruplexes. Curr Protoc Nucleic Acid Chem. 2009, Chapter 17: Unit 17 11-\nBugaut A, Balasubramanian S: A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes. Biochemistry. 2008, 47: 689-697.\nMergny JL, Phan AT, Lacroix L: Following G-quartet formation by UV-spectroscopy. FEBS Lett. 1998, 435: 74-78.\nHe Y, Tian Y, Mao C: Human telomeric DNA sequences have a peroxidase apoenzyme activity. Mol Biosyst. 2009, 5: 238-240.\nLi Y, Li X, Ji X, Li X: Formation of G-quadruplex-hemin DNAzyme based on human telomere elongation and its application in telomerase activity detection. Biosens Bioelectron. 2011, 26: 4095-4098.\nCheng X, Liu X, Bing T, Cao Z, Shangguan D: General peroxidase activity of G-quadruplex-hemin complexes and its application in ligand screening. Biochemistry. 2009, 48: 7817-7823.\nStefan L, Denat F, Monchaud D: Insights into how nucleotide supplements enhance the peroxidase-mimicking DNAzyme activity of the G-quadruplex\u002Fhemin system. Nucleic Acids Res. 2012, 40: 8759-8772.",{"EN":1656},"A 39-base-pair sequence (Pu39WT) located 58 to 19 base pairs upstream of the Bcl-2 P1 promoter has been implicated in the formation of an intramolecular mixed G-quadruplex structure and is believed to play a major role in the regulation of bcl-2 transcription. However, an extensive functional exploration requires further investigation. To further exploit the structure–function relationship of the Pu39WT-hemin DNAzyme, the secondary structure and peroxidase activity of the Pu39WT-hemin complex were investigated. Experimental results showed that when Pu39WT was incubated with hemin, it formed a uniparallel G-quadruplex-hemin complex in K+ or Na+ solution, rather than a mixed hybrid without bound hemin. Also, Pu39WT-hemin showed peroxidase activity (ABTS2−) in the presence of H2O2 to produce the colored radical anion (ABTS•-), which could then be used to determine the parameters governing the catalytic efficiency and reveal the peroxidase activity of the Pu39WT-hemin DNAzyme. These results demonstrate the general peroxidase activity of Pu39WT-hemin DNAzyme, which is an intramolecular parallel G-quadruplex structure. This peroxidase activity of hemin complexed with the G-quadruplex-forming sequence in the Bcl-2 gene promoter may imply a potential mechanism of hemin-mediated cellular injury.",{"EN":1658},"General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter",{"VOID":1660},"10.1186\u002F1752-153X-8-43","https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-153X-8-43",[1663,1678,1690],{"id":1664,"sortIndex":19,"researcher":18,"roles":1665,"affiliations":1666,"properties":1675},"59260c66-33b6-444f-a378-56d2424505fb",[122],[1667],{"id":18,"sortIndex":19,"affiliation":1668,"properties":18},{"id":1669,"createTime":1670,"updateTime":1670,"relativeEntities":1671,"slug":18,"properties":1672,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"2fc963f1-232c-4aff-845f-8be0cc29f608","2023-12-04T06:43:29.453+00:00",[],{"title":1673},{"VI":1674},"Department of Laboratory Medicine, The First Hospital of China, Medical University, Shenyang, China",{"title":1676},{"VI":1677},"Bo Liu",{"id":1679,"sortIndex":138,"researcher":18,"roles":1680,"affiliations":1681,"properties":1687},"c235f7a7-ea23-428d-9b13-4497844d7ffd",[122],[1682],{"id":18,"sortIndex":19,"affiliation":1683,"properties":18},{"id":1669,"createTime":1670,"updateTime":1670,"relativeEntities":1684,"slug":18,"properties":1685,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1686},{"VI":1674},{"title":1688},{"VI":1689},"Da Li",{"id":1691,"sortIndex":120,"researcher":18,"roles":1692,"affiliations":1693,"properties":1699},"d3378772-cff6-4e04-aea9-5d7192a17fb6",[122],[1694],{"id":18,"sortIndex":19,"affiliation":1695,"properties":18},{"id":1669,"createTime":1670,"updateTime":1670,"relativeEntities":1696,"slug":18,"properties":1697,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1698},{"VI":1674},{"title":1700},{"VI":1701},"Hong Shang",{"url":1661,"publisher":1703,"properties":1722},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1704,"slug":10,"properties":1705,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1708,"manageAffiliations":1709,"indexDatabases":1710,"url":18,"thumbnailPath":18,"statistic":1717,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1706,"title":1707},{"VOID":13},{"EN":15},[],[],[1711],{"id":24,"indexDatabase":1712,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":1713,"label":1714,"description":1715,"key":34,"publicationTags":1716,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":1718,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":1719,"totalCitation":65,"totalCitationByYear":1720,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":1721,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":1723,"pages":1725},{"VOID":1724},"8",{"VOID":1726},"1-7","2014-07-01",2014,{"id":1730,"createTime":1731,"updateTime":1731,"relativeEntities":1732,"slug":1733,"properties":1734,"entityType":113,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1743,"fullTextUrl":18,"authors":1744,"publicationType":236,"publisherRelationship":1816,"citationCount":18,"citationInfo":18,"publishDate":1841,"publishYear":1231,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":264},"033c7ec8-5e65-4808-b649-d2080a73bf76","2023-11-25T23:35:46.083+00:00",[],"Characterization-of-in-vivo-metabolites-in-rat-urine-following-an-oral-dose-of-masitinib-by-liquid-chromatography-tandem-mass-spectrometry",{"references":1735,"abstract":1737,"title":1739,"doi":1741},{"VOID":1736},"Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T et al (2008) Cancer statistics, 2008. CA Cancer J Clin 58(2):71–96\nSinha R, El-Bayoumy K (2004) Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds. Curr Cancer Drug Targets 4(1):13–28\nCozzi P, Mongelli N, Suarato A (2004) Recent anticancer cytotoxic agents. Curr Med Chem Anti Cancer Agents 4(2):93–121\nBarinaga M (1997) From bench top to bedside. Science 278(5340):1036–1039\nSchlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2):211–225\nÖzvegy-Laczka C, Cserepes J, Elkind NB, Sarkadi B (2005) Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters. Drug Resist Updates 8(1):15–26\nSteeghs N, Nortier JW, Gelderblom H (2007) Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments. Ann Surg Oncol 14(2):942–953\nNatoli C, Perrucci B, Perrotti F, Falchi L, Iacobelli S (2010) Tyrosine kinase inhibitors. Curr Cancer Drug Targets 10(5):462–483\nDaly M, Sheppard S, Cohen N, Nabity M, Moussy A, Hermine O et al (2011) Safety of masitinib mesylate in healthy cats. J Vet Intern Med 25(2):297–302\nMarech I, Patruno R, Zizzo N, Gadaleta C, Introna M, Zito AF et al (2014) Masitinib (AB1010), from canine tumor model to human clinical development: where we are? Crit Rev Oncol Hematol 91(1):98–111\nDubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Castéran N et al (2009) Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS ONE 4(9):e7258\nLortholary O, Chandesris MO, Livideanu CB, Paul C, Guillet G, Jassem E et al (2017) Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study. Lancet 389(10069):612–620\nKumar GN, Surapaneni S (2001) Role of drug metabolism in drug discovery and development. Med Res Rev 21(5):397–411\nKadi AA, Al-Shakliah NS, Yin W, Rahman AM (2017) In vitro investigation of metabolic profiling of newly developed topoisomerase inhibitors (ethyl fluorescein hydrazones, EtFLHs) in RLMs by LC–MS\u002FMS. J Chromatogr B 1054:93–104\nRahman AM, Al-Shakliah NS, Yin W, Kadi AA (2017) In vitro Investigation of Metabolic Profiling of a Potent Topoisomerase Inhibitors Fluorescein Hydrazones (FLHs) in RLMs by LC-MS\u002FMS. J Chromatogr B 1054:27–35\nAttwa MW, Kadi AA, Darwish HW, Alrabiah H (2018) LC-MS\u002FMS reveals the formation of reactive ortho-quinone and iminium intermediates in saracatinib metabolism: phase I metabolic profiling. Clin Chim Acta 482:84–94\nAttwa MW, Kadi AA, Darwish HW, Amer SM, Alrabiah H (2018) A reliable and stable method for the determination of foretinib in human plasma by LC-MS\u002FMS: application to metabolic stability investigation and excretion rate. Eur J Mass Spectrom 1469066718768327. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1469066718768327\nMasic LP (2011) Role of cyclic tertiary amine bioactivation to reactive iminium species: structure toxicity relationship. Curr Drug Metab 12(1):35–50\nKadi AA, Attwa M, Darwish HW (2018) LC-ESI-MS\u002FMS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways. RSC Adv 8(3):1182–1190\nShin J-W, Seol I-C, Son C-G (2010) Interpretation of animal dose and human equivalent dose for drug development. J Korean Med 31(3):1–7\nNair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7(2):27–31\nReagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J Off Publ Fed Am Soc Exp Biol 22(3):659–661 (Epub 2007\u002F10\u002F19)\nVaraprath S, Salyers KL, Plotzke KP, Nanavati S (1999) Identification of metabolites of octamethylcyclotetrasiloxane (D(4)) in rat urine. Drug Metab Dispos Biol Fate Chem 27(11):1267–1273\nBylda C, Thiele R, Kobold U, Volmer DA (2014) Recent advances in sample preparation techniques to overcome difficulties encountered during quantitative analysis of small molecules from biofluids using LC–MS\u002FMS. Analyst 139(10):2265–2276\nYoshida M, Akane A (1999) Subzero-temperature liquid − liquid extraction of benzodiazepines for high-performance liquid chromatography. Anal Chem 71(9):1918–1921\nValente IM, Gonçalves LM, Rodrigues JA (2013) Another glimpse over the salting-out assisted liquid–liquid extraction in acetonitrile\u002Fwater mixtures. J Chromatogr A 1308:58–62\nAmer S, Kadi AA, Darwish HW, Attwa MW (2017) Identification and characterization of in vitro phase I and reactive metabolites of masitinib using a LC-MS\u002FMS method: bioactivation pathway elucidation. RSC Adv 7(8):4479–4491\nAmer SM, Kadi AA, Darwish HW, Attwa MW (2017) LC–MS\u002FMS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate. Chem Cent J 11(1):136",{"EN":1738},"Masitinib (MST) is an orally administered drug that targets mast cells and macrophages, important cells for immunity, by inhibiting a limited number of tyrosine kinases. It is currently registered in Europe and USA for the treatment of mast cell tumors in dogs. AB Science announced that the European Medicines Agency has accepted a conditional marketing authorization application for MST to treat amyotrophic lateral sclerosis. In our work, we focused on studying in vivo metabolism of MST in Sprague–Dawley rats. Single oral dose of MST (33 mg kg−1) was given to Sprague–Dawley rats (kept in metabolic cages) using oral gavage. Urine was collected and filtered at 0, 6, 12, 18, 24, 48, 72 and 96 h from MST dosing. An equal amount of ACN was added to urine samples. Both organic and aqueous layers were injected into liquid chromatography-tandem mass spectrometry (LC–MS\u002FMS) to detect in vivo phase I and phase II MST metabolites. The current work reports the identification and characterization of twenty in vivo phase I and four in vivo phase II metabolites of MST by LC–MS\u002FMS. Phase I metabolic pathways were reduction, demethylation, hydroxylation, oxidative deamination, oxidation and N-oxide formation. Phase II metabolic pathways were the direct conjugation of MST, N-demethyl metabolites and oxidative metabolites with glucuronic acid. Part of MST dose was excreted unchanged in urine. The literature review showed no previous articles have been made on in vivo metabolism of MST or detailed structural identification of the formed in vivo phase I and phase II metabolites.\n                  \n                    \n                  \n                \n",{"EN":1740},"Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry",{"VOID":1742},"10.1186\u002Fs13065-018-0429-y","https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13065-018-0429-y",[1745,1762,1785,1797],{"id":1746,"sortIndex":19,"researcher":18,"roles":1747,"affiliations":1748,"properties":1759},"b2f33e8c-e730-4b59-bb18-1273d5a3d1a7",[122],[1749],{"id":18,"sortIndex":19,"affiliation":1750,"properties":18},{"id":1751,"createTime":1752,"updateTime":1753,"relativeEntities":1754,"slug":1755,"properties":1756,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"15a2e07c-2e31-40c9-8f45-1c9961bd52ca","2024-04-06T19:51:00.987+00:00","2024-10-13T06:40:52.228+00:00",[],"Department-of-Pharmaceutical-Chemistry-College-of-Pharmacy-King-Saud-University-Riyadh-Saudi-Arabia",{"title":1757},{"VI":1758},"Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia",{"title":1760},{"VI":1761},"Adnan A. Kadi",{"id":1763,"sortIndex":120,"researcher":18,"roles":1764,"affiliations":1765,"properties":1782},"ff9de02f-b8c1-4fd3-b94e-b66f7f82dc58",[122],[1766,1771],{"id":18,"sortIndex":19,"affiliation":1767,"properties":18},{"id":1751,"createTime":1752,"updateTime":1753,"relativeEntities":1768,"slug":1755,"properties":1769,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1770},{"VI":1758},{"id":1772,"sortIndex":138,"affiliation":1773,"properties":1781},"dd490126-356e-42fa-9ded-60aca69cdbbe",{"id":1774,"createTime":1775,"updateTime":1775,"relativeEntities":1776,"slug":1777,"properties":1778,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"15a5a3ea-6c73-4a07-aa54-2afe69c3b21f","2024-04-12T00:17:37.540+00:00",[],"Analytical-Chemistry-Department-Faculty-of-Pharmacy-Cairo-University-Cairo-Egypt",{"title":1779},{"EN":1780},"Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt",{},{"title":1783},{"VI":1784},"Hany W. Darwish",{"id":1786,"sortIndex":138,"researcher":18,"roles":1787,"affiliations":1788,"properties":1794},"fce15492-9ed4-42fa-b159-c88d76394b14",[122],[1789],{"id":18,"sortIndex":19,"affiliation":1790,"properties":18},{"id":1774,"createTime":1775,"updateTime":1775,"relativeEntities":1791,"slug":1777,"properties":1792,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1793},{"EN":1780},{"title":1795},{"VI":1796},"Sawsan M. Amer",{"id":1798,"sortIndex":194,"researcher":18,"roles":1799,"affiliations":1800,"properties":1813},"f85d55c9-abb7-4714-b8cf-b3ce8ac98b03",[122],[1801,1806],{"id":18,"sortIndex":19,"affiliation":1802,"properties":18},{"id":1751,"createTime":1752,"updateTime":1753,"relativeEntities":1803,"slug":1755,"properties":1804,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1805},{"VI":1758},{"id":1807,"sortIndex":138,"affiliation":1808,"properties":1812},"b41b5cd6-ba81-43bb-918e-487f10d815f6",{"id":1774,"createTime":1775,"updateTime":1775,"relativeEntities":1809,"slug":1777,"properties":1810,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1811},{"EN":1780},{},{"title":1814},{"VI":1815},"Mohamed W. Attwa",{"url":1743,"publisher":1817,"properties":1836},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1818,"slug":10,"properties":1819,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1822,"manageAffiliations":1823,"indexDatabases":1824,"url":18,"thumbnailPath":18,"statistic":1831,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1820,"title":1821},{"VOID":13},{"EN":15},[],[],[1825],{"id":24,"indexDatabase":1826,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":1827,"label":1828,"description":1829,"key":34,"publicationTags":1830,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":1832,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":1833,"totalCitation":65,"totalCitationByYear":1834,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":1835,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":1837,"pages":1839},{"VOID":1838},"12",{"VOID":1840},"1-18","2018-05-15",{"id":1843,"createTime":1844,"updateTime":1845,"relativeEntities":1846,"slug":1847,"properties":1848,"entityType":113,"verifyStatus":114,"verifyTime":1845,"verifyNote":115,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1855,"fullTextUrl":18,"authors":1856,"publicationType":236,"publisherRelationship":1872,"citationCount":18,"citationInfo":18,"publishDate":1897,"publishYear":1898,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":264},"aab8ae34-2da5-4b36-a198-ade0ccb98f81","2023-12-18T00:38:07.719+00:00","2025-01-24T23:32:06.518+00:00",[],"Efficient-3D-pharmacophore-alignment-as-a-tool-for-structure-based-modeling-and-scoring",{"references":1849,"title":1851,"doi":1853},{"VOID":1850},"Wolber G, Dornhofer AA, Langer T: Efficient overlay of small organic molecules using 3D pharmacophores. J Comput Aided Mol Des. 2007, 20 (12): 773-788. 10.1007\u002Fs10822-006-9078-7.",{"EN":1852},"Efficient 3D pharmacophore alignment as a tool for structure-based modeling and scoring",{"VOID":1854},"10.1186\u002F1752-153X-2-S1-P49","https:\u002F\u002Fbmcchem.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-153X-2-S1-P49",[1857],{"id":1858,"sortIndex":19,"researcher":18,"roles":1859,"affiliations":1860,"properties":1869},"1253555c-0cda-4f94-9250-a5b4a878a67a",[122],[1861],{"id":18,"sortIndex":19,"affiliation":1862,"properties":18},{"id":1863,"createTime":1864,"updateTime":1864,"relativeEntities":1865,"slug":18,"properties":1866,"entityType":132,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"d96df11c-27ba-43f2-800e-dd8be4065bb4","2023-12-18T00:38:07.727+00:00",[],{"title":1867},{"VI":1868},"Inte:Ligand GmbH, Vienna, Austria",{"title":1870},{"VI":1871},"Gerhard Wolber",{"url":1855,"publisher":1873,"properties":1892},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1874,"slug":10,"properties":1875,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1878,"manageAffiliations":1879,"indexDatabases":1880,"url":18,"thumbnailPath":18,"statistic":1887,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1876,"title":1877},{"VOID":13},{"EN":15},[],[],[1881],{"id":24,"indexDatabase":1882,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":1883,"label":1884,"description":1885,"key":34,"publicationTags":1886,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":1888,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":1889,"totalCitation":65,"totalCitationByYear":1890,"totalCitationPerPublication":79,"totalCitationPerPublicationByYear":1891,"hindexLast5Year":93,"hindex":93},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":47,"2019":48,"2020":49},{"2007":53,"2008":54,"2009":55,"2010":56,"2011":57,"2012":58,"2013":59,"2014":60,"2015":61,"2016":62,"2017":63,"2018":64},{"2007":67,"2008":68,"2009":69,"2010":70,"2011":71,"2012":72,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":78},{"2007":81,"2008":82,"2009":83,"2010":84,"2011":85,"2012":86,"2013":87,"2014":88,"2015":89,"2016":90,"2017":91,"2018":92},{"volume":1893,"pages":1895},{"VOID":1894},"2",{"VOID":1896},"1-1","2008-03-26",2008]