[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_b25c3982-ab72-4ee9-8001-e28b50cda2fc":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:b25c3982-ab72-4ee9-8001-e28b50cda2fc,\"}":156},{"code":4,"data":5,"meta":18},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":20,"manageAffiliations":27,"indexDatabases":42,"url":18,"thumbnailPath":18,"statistic":77,"gsStatistic":18,"type":18,"analyzePriority":18},"b25c3982-ab72-4ee9-8001-e28b50cda2fc","2024-04-22T01:17:25.947+00:00","2025-11-21T10:02:18.726+00:00",[],"Springer-Science-and-Business-Media-LLC",{"title":12,"eissn":14},{"EN":13},"Springer Science and Business Media LLC",{"VOID":15},"1471-2466","PUBLISHER","PENDING",null,0,[21],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":23,"label":24,"description":26,"parentId":18,"standard":18,"scholarHubFieldId":18},"b3b0f9d8-a31a-43cf-9f7d-d2ce7381db6a",[],{"EN":25},"Pulmonary and Respiratory Medicine",{},[28,35],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":30,"slug":18,"properties":31,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":34,"statistic":18},"c5894808-4e99-4047-bbce-594f58821845",[],{"title":32},{"EN":33},"BioMed Central Ltd.",[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":37,"slug":18,"properties":38,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":41,"statistic":18},"67883518-0c98-470e-b6b0-160ab49bb03d",[],{"title":39},{"EN":40},"BMC",[],[43,60],{"id":44,"indexDatabase":45,"url":57,"indexYears":18,"academicFieldIds":58,"indexDatabaseRanking":18},"055f1b7f-23ae-4b3f-b669-56a5114b31b5",{"id":46,"createTime":18,"updateTime":18,"relativeEntities":47,"label":48,"description":50,"key":53,"publicationTags":54,"standard":18},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":49,"VI":49},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":51,"VI":52},"SCIE database","Cơ sở dữ liệu SCIE","scie",[55,56],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1471-2466",[59],"5a4bdced-b504-414b-926b-133e43a206cf",{"id":61,"indexDatabase":62,"url":72,"indexYears":73,"academicFieldIds":74,"indexDatabaseRanking":76},"7dec63bc-30b2-47c8-a64f-10a01c24f087",{"id":63,"createTime":18,"updateTime":18,"relativeEntities":64,"label":65,"description":67,"key":69,"publicationTags":70,"standard":18},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":66,"VI":66},"Scopus - Elsevier",{"EN":66,"VI":68},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[71],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F18026","2001-2025",[75],"52ed8621-9465-4306-9795-51cbb342ffa8","SCOPUS__Q1",{"impactFactor":19,"impactFactorByYear":78,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":94,"totalCitation":116,"totalCitationByYear":117,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":136,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},0.34,0.56,0.42,0.44,0.6,0.69,0.54,0.68,0.73,0.5,0.61,0.41,200,57,2436,{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},4,3,10,21,13,19,34,48,55,51,136,112,113,153,129,183,231,291,286,267,82,6927,{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},84,188,94,322,88,401,186,204,862,781,558,917,506,517,437,418,131,2.84,{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},1,8.4,8.95,1.62,4.95,9.47,1.83,11.79,3.38,6.34,6.97,4.94,5.99,3.92,2.83,1.89,1.44,0.46,42,{"meta":157,"data":159},{"total":158},"2448",[160,311,462,749,919,1078,1374,1657,1945,2323],{"id":161,"createTime":162,"updateTime":163,"relativeEntities":164,"slug":165,"properties":166,"entityType":176,"verifyStatus":177,"verifyTime":178,"verifyNote":179,"languages":18,"translateLanguages":180,"viewCount":19,"primaryUrl":182,"fullTextUrl":18,"authors":183,"publicationType":259,"publisherRelationship":260,"citationCount":18,"citationInfo":18,"publishDate":307,"publishYear":308,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":309,"openAccess":18,"references":18,"isForceReanalyzing":310},"50748186-3ac1-4697-9eaf-37f91fe6acb2","2024-01-25T19:33:19.976+00:00","2026-09-10T05:14:58.256+00:00",[],"An-8-week-open-label-interventional-multicenter-study-to-explore-the-lung-clearance-index-as-endpoint-for-clinical-trials-in-cystic-fibrosis-patients-8-years-of-age-chronically-infected-with-Pseudomonas-aeruginosa",{"abstract":167,"title":169,"references":172,"doi":174},{"EN":168},"Forced expiratory volume in 1 second (FEV1) is the only parameter currently recognized as a surrogate endpoint in cystic fibrosis (CF) trials. However, FEV1 is relatively insensitive to changes in the small airways of patients with milder lung disease. This pilot study aimed to explore the lung clearance index (LCI) as a marker for use in efficacy trials with inhaled antibiotics in CF. This open-label, single-arm study enrolled CF patients with Pseudomonas aeruginosa infection, who were treated with tobramycin (28-day on\u002Foff regime). FEV1, LCI and bacterial load in sputum (CFU) were assessed at baseline, after 1, 4 and 8 weeks of treatment. All patients (n = 17) showed elevated LCI of > 11 despite 3 patients having normal FEV1 (> 90% predicted) at baseline. Overall, LCI improved in 8 (47%) patients and FEV1 in 9 (53%) patients. At week 4, LCI improved by 0.88, FEV1 increased by 0.52%, and P. aeruginosa reduced by 30,481.3 CFU\u002FmL. These changes were however statistically non-significant. Six adverse events occurred in 5\u002F17 (29.4%) patients, most of which were mild-to-moderate in severity. Due to the low evaluable sample size, no specific trend was observed related to the changes between LCI, FEV1 and CFU. Based on the individual data from this study and from recently published literature, LCI has been shown to be a more sensitive parameter than FEV1 for lung function. LCI can be hypothesized to be an appropriate endpoint for efficacy trials in CF patients if the heterogeneity in lung function is limited by enrolling younger patients or patients with more milder lung disease and thus, limiting the ventilation inhomogeneities. The study is registered with ClinicalTrials.gov, identifier: NCT02248922.",{"EN":170,"VI":171},"An 8 week open-label interventional multicenter study to explore the lung clearance index as endpoint for clinical trials in cystic fibrosis patients ≥8 years of age, chronically infected with Pseudomonas aeruginosa","Nghiên cứu can thiệp đa trung tâm, nhãn mở kéo dài 8 tuần nhằm thăm dò chỉ số thanh thải phổi làm tiêu chí đánh giá cho các thử nghiệm lâm sàng ở bệnh nhân xơ nang ≥8 tuổi bị nhiễm mạn tính Pseudomonas aeruginosa",{"VOID":173},"Riordan JR, Rommens JM, Kerem B, Alon N, et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science. 1989;245:1066–73.\nElborn JS. Cystic fibrosis. Lancet. 2016;388:2519–31.\nLangton Hewer SC, Smyth AR. Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Database Syst Rev. 2017;4:CD004197.\nSmith S, Rowbotham NJ, Regan KH. Inhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis. Cochrane Database Syst Rev. 2018;3:CD001021.\nStanojevic S, Ratjen F. Physiologic endpoints for clinical studies for cystic fibrosis. J Cyst Fibros. 2016;15:416–23.\nPittman JE, Davis SD. Decline in forced expiratory volume in 1 second in cystic fibrosis-watch the pendulum swing. J Pediatr. 2016;169:7–9.\nKonstan MW, McKone EF, Moss RB, Marigowda G, et al. Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study. Lancet Respir Med. 2017;5:107–18.\nSawicki GS, McKone EF, Pasta DJ, Millar SJ, et al. Sustained benefit from ivacaftor demonstrated by combining clinical trial and cystic fibrosis patient registry data. Am J Respir Crit Care Med. 2015;192:836–42.\nMott LS, Park J, Murray CP, Gangell CL, et al. Progression of early structural lung disease in young children with cystic fibrosis assessed using CT. Thorax. 2012;67:509–16.\nBreuer O, Caudri D, Stick S, Turkovic L. Predicting disease progression in cystic fibrosis. Expert Rev Respir Med. 2018;12:905–17.\nJudge EP, Dodd JD, Masterson JB, Gallagher CG. Pulmonary abnormalities on high-resolution CT demonstrate more rapid decline than FEV1 in adults with cystic fibrosis. Chest. 2006;130:1424–32.\nSubbarao P, Milla C, Aurora P, Davies JC, et al. Multiple-breath washout as a lung function test in cystic fibrosis. A Cystic Fibrosis Foundation workshop report. Ann Am Thorac Soc. 2015;12:932–9.\nKent L, Reix P, Innes JA, Zielen S, et al. Lung clearance index: evidence for use in clinical trials in cystic fibrosis. J Cyst Fibros. 2014;13:123–38.\nHorsley AR, Gustafsson PM, Macleod KA, Saunders C, et al. Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax. 2008;63:135–40.\nRatjen F, Hug C, Marigowda G, Tian S, et al. Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial. Lancet Respir Med 2017;5:557–567. Epub 2017 Jun 9.\nGreen K, Kongstad T, Skov M, Buchvald F, et al. Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis. J Cyst Fibros. 2018;17(2):242–8.\nHoultz B, Green K, Lindblad A, Singer F, et al. Tidal N2 washout ventilation inhomogeneity indices in a reference population aged 7–70 years. Eur Respir J. 2012;40:P3797.\nTiddens HA, Bos AC, Mouton JW, Devadason S, et al. Inhaled antibiotics: dry or wet? Eur Respir J. 2014;44(5):1308–18.\nDavies JC, Sheridan H, Lee P-S, Song T, et al. Effect of ivacaftor on lung function in subjects with CF who have the G551DCFTR mutation and mild lung disease: a comparison of lung clearance index (LCI) vs. spirometry. J Cyst Fibros. 2012;11(Suppl. 1):S15.\nDavies J, Sheridan H, Bell N, Cunningham S, et al. Assessment of clinical response to ivacaftor with lung clearance index in cystic fibrosis patients with a G551DCFTR mutation and preserved spirometry: a randomised controlled trial. Lancet Respir Med. 2013;1:630–8.\nSvedberg M, Gustafsson PM, Robinson PD, Rosberg M, et al. Variability of lung clearance index in clinically stable cystic fibrosis lung disease in school age children. J Cyst Fibros. 2018;17:236–41.\nEllemunter H, Eder J, Fuchs S, Gappa M, et al. Long-term improvement of lung clearance index in patients with mild cystic fibrosis lung disease: does hypertonic saline play a role? J Cyst Fibros. 2016 Jan;15(1):123–6.\nWelsh L, Nesci C, Tran H, Tomai M, et al. Lung clearance index during hospital admission in school-age children with cystic fibrosis. J Cyst Fibros. 2014;13:687–91.\nYammine S, Bigler A, Casaulta C, Singer F, et al. Reasons for heterogeneous change in LCI in children with cystic fibrosis after antibiotic treatment. Thorax. 2014;69:183.\nSonneveld N, Stanojevic S, Amin R, Aurora P, et al. Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations. Eur Respir J. 2015;46:1055–64.\nHatziagorou E, Avramidou V, Kirvassilis F, Tsanakas J. Use of lung clearance index to assess the response to intravenous treatment in cystic fibrosis. Hippokratia. 2015;19:47–52.\nVanDevanter DR, Ballmann M, Flume PA. Applying clinical outcome variables to appropriate aerosolized antibiotics for the treatment of patients with cystic fibrosis. Respir Med. 2011;105:S18–23.\nRobinson PD, Goldman MD, Gustafsson PM. Inert gas washout: theoretical background and clinical utility in respiratory disease. Respiration. 2009;78:339–55.\nGrosse-Onnebrink J, Mellies U, Olivier M, Werner C, et al. Chest physiotherapy can affect the lung clearance index in cystic fibrosis patients. Pediatr Pulmonol. 2017;52:625–31.\nPfleger A, Steinbacher M, Schwantzer G, Weinhandl E, et al. Short-term effects of physiotherapy on ventilation inhomogeneity in cystic fibrosis patients with a wide range of lung disease severity. J Cyst Fibros. 2015;14:627–31.\nRamsey BW, Pepe MS, Quan JM, Otto KL, et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic fibrosis inhaled tobramycin study group. N Engl J Med. 1999;340:23–30.\nKonstan MW, Flume PA, Kappler M, Chiron R, et al. Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: the EAGER trial. J Cyst Fibros. 2011;10:54–61.\nDasenbrook EC, Konstan MW, VanDevanter DR. Association between the introduction of a new cystic fibrosis inhaled antibiotic class and change in prevalence of patients receiving multiple inhaled antibiotic classes. J Cyst Fibros. 2015;14:370–5.",{"VOID":175},"10.1186\u002Fs12890-020-01201-y","PUBLICATION","VERIFIED","2025-01-20T03:43:11.942+00:00","Auto Verify",[181],"VI","https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-020-01201-y",[184,200,215,231,246],{"id":185,"sortIndex":19,"researcher":18,"roles":186,"affiliations":188,"properties":197,"displayName":199,"givenName":18,"familyName":18},"395c687a-6242-4edd-bf3d-29189944f834",[187],"AUTHOR",[189],{"id":190,"sortIndex":19,"affiliation":191,"properties":18},"758f76c0-1b74-4ed8-a7d5-7b95b3234722",{"id":190,"createTime":18,"updateTime":18,"relativeEntities":192,"slug":18,"properties":193,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":196,"statistic":18},[],{"title":194},{"VI":195},"Division for Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen – Ruhrlandklinik, Essen, Germany",[],{"title":198},{"VI":199},"Sivagurunathan Sutharsan",{"id":201,"sortIndex":137,"researcher":18,"roles":202,"affiliations":203,"properties":212,"displayName":214,"givenName":18,"familyName":18},"d65cc0ac-8247-42d2-93f8-fc8c62594a8f",[187],[204],{"id":205,"sortIndex":19,"affiliation":206,"properties":18},"2fdc1455-88c9-4fe2-a585-a135e65997cb",{"id":205,"createTime":18,"updateTime":18,"relativeEntities":207,"slug":18,"properties":208,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":211,"statistic":18},[],{"title":209},{"VI":210},"Cystic Fibrosis Center for Adults, University Hospital Munich, Munich, Germany",[],{"title":213},{"VI":214},"Susanne Naehrig",{"id":216,"sortIndex":217,"researcher":18,"roles":218,"affiliations":219,"properties":228,"displayName":230,"givenName":18,"familyName":18},"a3d4fbd1-4747-41eb-8d07-69ff10d7a598",2,[187],[220],{"id":221,"sortIndex":19,"affiliation":222,"properties":18},"610c0309-761a-4201-acfd-90cc7716cbe5",{"id":221,"createTime":18,"updateTime":18,"relativeEntities":223,"slug":18,"properties":224,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":227,"statistic":18},[],{"title":225},{"VI":226},"Pediatric Pulmonology and Sleep Medicine, Children’s Hospital, University of Duisburg-Essen, Essen, Germany",[],{"title":229},{"VI":230},"Uwe Mellies",{"id":232,"sortIndex":96,"researcher":18,"roles":233,"affiliations":234,"properties":243,"displayName":245,"givenName":18,"familyName":18},"168028df-ccb3-4762-8b89-743399dbcbe3",[187],[235],{"id":236,"sortIndex":19,"affiliation":237,"properties":18},"a007ea9b-ab86-4d15-8ca1-b2c09ad5d8d0",{"id":236,"createTime":18,"updateTime":18,"relativeEntities":238,"slug":18,"properties":239,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":242,"statistic":18},[],{"title":240},{"VI":241},"Novartis Pharma GmbH, Nürnberg, Germany",[],{"title":244},{"VI":245},"Christian Sieder",{"id":247,"sortIndex":95,"researcher":18,"roles":248,"affiliations":249,"properties":256,"displayName":258,"givenName":18,"familyName":18},"6deafdd6-05a3-44e2-91fc-650d38090c30",[187],[250],{"id":236,"sortIndex":19,"affiliation":251,"properties":18},{"id":236,"createTime":18,"updateTime":18,"relativeEntities":252,"slug":18,"properties":253,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":255,"statistic":18},[],{"title":254},{"VI":241},[],{"title":257},{"VI":258},"Jörg Ziegler","ARTICLE",{"url":182,"publisher":261,"properties":302},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":262,"slug":10,"properties":263,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":266,"manageAffiliations":271,"indexDatabases":282,"url":18,"thumbnailPath":18,"statistic":297,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":264,"eissn":265},{"EN":13},{"VOID":15},[267],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":268,"label":269,"description":270,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[272,277],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":273,"slug":18,"properties":274,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":276,"statistic":18},[],{"title":275},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":278,"slug":18,"properties":279,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":281,"statistic":18},[],{"title":280},{"EN":40},[],[283,290],{"id":61,"indexDatabase":284,"url":72,"indexYears":73,"academicFieldIds":289,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":285,"label":286,"description":287,"key":69,"publicationTags":288,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":291,"url":57,"indexYears":18,"academicFieldIds":296,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":292,"label":293,"description":294,"key":53,"publicationTags":295,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":298,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":299,"totalCitation":116,"totalCitationByYear":300,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":301,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":303,"volume":305},{"VOID":304},"1-8",{"VOID":306},"20","2020-06-12",2020,[55,76],false,{"id":312,"createTime":313,"updateTime":314,"relativeEntities":315,"slug":316,"properties":317,"entityType":176,"verifyStatus":177,"verifyTime":327,"verifyNote":179,"languages":18,"translateLanguages":328,"viewCount":19,"primaryUrl":329,"fullTextUrl":18,"authors":330,"publicationType":259,"publisherRelationship":412,"citationCount":18,"citationInfo":18,"publishDate":459,"publishYear":460,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":461,"openAccess":18,"references":18,"isForceReanalyzing":310},"726e9ac9-c6ec-4988-88db-8a19b9cdc994","2024-01-05T01:23:44.598+00:00","2026-09-06T06:14:20.727+00:00",[],"Ursolic-acid-alleviates-airway-vessel-remodeling-and-muscle-consumption-in-cigarette-smoke-induced-emphysema-rats",{"abstract":318,"title":320,"references":323,"doi":325},{"EN":319},"This study assessed the effects of ursolic acid (UA) on airway-vessel remodeling and muscle atrophy in cigarette smoke (CS)-induced emphysema rats and investigated potential underlying mechanisms. Emphysema was induced in a rat model with 3 months of CS exposure. Histology and immunohistochemistry (IHC) stains were used to assess airway-vessel remodeling and muscle atrophy-associated changes. Levels of cleaved-caspase3, 8-OHdG, and S100A4 were measured in airways and associated vessels to evaluate cell apoptosis, oxidant stress, epithelial-to-mesenchymal transition (EMT), and endothelial-to-mesenchymal transition (EndMT)-associated factors. Western blot and\u002For IHC analyses were performed to measure transforming growth factor-beta 1(TGF-β1)\u002FSmad2.3, alpha-smooth muscle actin (α-SMA), and insulin-like growth factor 1 (IGF1) expression. We also gave cultured HBE and HUVEC cells Cigarette Smoke Extract (CSE) administration and UA intervention. Using Western blot method to measure TGF-β1\u002FSmad2.3, α-SMA, S100A4, and IGF1 molecules expression. UA decreased oxidant stress and cell apoptosis in airway and accompanying vascular walls of cigarette smoke-induced emphysema model rats. UA alleviated EMT, EndMT, changes associated with airway-vessel remodeling and muscle atrophy. The UA effects were associated with IGF1 and TGF-β1\u002FSmad2.3 pathways. UA reduced EMT, EndMT, airway-vessel remodeling, and musculi soleus atrophy in CS-induced emphysema model rats at least partly through IGF1 and TGF-β1\u002FSmad2.3 signaling pathways.",{"EN":321,"VI":322},"Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats","Axit ursolic làm giảm tái cấu trúc mạch máu đường thở và teo cơ ở chuột cống mắc khí phế thũng do khói thuốc lá",{"VOID":324},"Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM, Menezes AM, Sullivan SD, Lee TA, Weiss KB, et al. International variation in the prevalence of COPD (the BOLD study): a population-based prevalence study. Lancet. 2007;370(9589):741–50.\nWang C, Xu J, Yang L, Xu Y, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China pulmonary health [CPH] study): a national cross-sectional study. Lancet. 2018;391(10131):1706–17.\nT O, K N, M T, S S. T H: analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am J Respir Crit Care Med. 2003;167(4):544–9.\nZhong N, Wang C, Yao W, Chen P, Kang J, Huang S, Chen B, Wang C, Ni D, Zhou Y, et al. Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey. Am J Respir Crit Care Med. 2007;176(8):753–60.\nOga T, Nishimura K, Tsukino M, Sato S, Hajiro T. Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am J Respir Crit Care Med. 2003;167(4):544–9.\nMcMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP. Lung-targeted overexpression of the NF-kappaB member RelB inhibits cigarette smoke-induced inflammation. Am J Pathol. 2011;179(1):125–33.\nGould NS, Min E, Gauthier S, Chu HW, Martin R, Day BJ. Aging adversely affects the cigarette smoke-induced glutathione adaptive response in the lung. Am J Respir Crit Care Med. 2010;182(9):1114–22.\nSoltani A, Walters EH, Reid DW, Shukla SD, Nowrin K, Ward C, Muller HK, Sohal SS. Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD. International journal of chronic obstructive pulmonary disease. 2016;11:2359–67.\nBaddini-Martinez J, de Padua AI. Chronic obstructive pulmonary disease: time to discuss new concepts. Lancet. 2016;388(10061):2740–1.\nBarreiro E, Gea J. Molecular and biological pathways of skeletal muscle dysfunction in chronic obstructive pulmonary disease. Chronic respiratory disease. 2016;13(3):297–311.\nBlanco I, Piccari L, Barbera JA. Pulmonary vasculature in COPD: the silent component. Respirology (Carlton, Vic). 2016;21(6):984–94.\nCosta TM, Costa FM, Moreira CA, Rabelo LM, Boguszewski CL, Borba VZ. Sarcopenia in COPD: relationship with COPD severity and prognosis. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2015;41(5):415–21.\nPera T, Zuidhof AB, Smit M, Menzen MH, Klein T, Flik G, Zaagsma J, Meurs H, Maarsingh H. Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2014;349(2):229–38.\nAlagappan VK, de Boer WI, Misra VK, Mooi WJ, Sharma HS. Angiogenesis and vascular remodeling in chronic airway diseases. Cell Biochem Biophys. 2013;67(2):219–34.\nSohal SS. Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD). Respir Investig. 2017;55(2):104–13.\nSohal S. Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD). Respir Investig. 2017;55(2):104–13.\nSohal S. Endothelial to mesenchymal transition (EndMT): an active process in chronic obstructive pulmonary disease (COPD)? Respir Res. 2016;17:20.\nHirota N, Martin J. Mechanisms of airway remodeling. Chest. 2013;144(3):1026–32.\nTakayanagi S, Kawata N, Tada Y, Ikari J, Matsuura Y, Matsuoka S, Matsushita S, Yanagawa N, Kasahara Y, Tatsumi K. Longitudinal changes in structural abnormalities using MDCT in COPD: do the CT measurements of airway wall thickness and small pulmonary vessels change in parallel with emphysematous progression? Int J Chron Obstruct Pulmon Dis. 2017;12:551–60.\nFathy E, Shafiek H, Morsi T, El Sabaa B, Elnekidy A, Elhoffy M, Atta M. Image-enhanced bronchoscopic evaluation of bronchial mucosal microvasculature in COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2447–55.\nSoltani A, Walters E, Reid D, Shukla S, Nowrin K, Ward C, Muller H, Sohal S. Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2359–67.\nHarkness L, Kanabar V, Sharma H, Westergren-Thorsson G, Larsson-Callerfelt A. Pulmonary vascular changes in asthma and COPD. Pulm Pharmacol Ther. 2014;29(2):144–55.\nSeeger W, Adir Y, Barberà J, Champion H, Coghlan J, Cottin V, De Marco T, Galiè N, Ghio S, Gibbs S, et al. Pulmonary hypertension in chronic lung diseases. J Am Coll Cardiol. 2013;62(25 Suppl):D109–16.\nKhanna A, Guo M, Mehra M, Royal W. Inflammation and oxidative stress induced by cigarette smoke in Lewis rat brains. J Neuroimmunol. 2013;254(1–2):69–75.\nLunghi B, De Cunto G, Cavarra E, Fineschi S, Bartalesi B, Lungarella G, Lucattelli M. Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema. PLoS One. 2015;10(3):e0119797.\nRichardson L, Dixon C, Aguilera-Aguirre L, Menon R. Oxidative stress-induced TGF-beta\u002FTAB1-mediated p38MAPK activation in human amnion epithelial cells. Biol Reprod. 2018.\nChen H, Liao K, Cui-Zhao L, Qiang-Wen F, Feng-Zeng X, Ping-Wu F, Liang-Guo S, Juan-Chen Y. Cigarette smoke extract induces apoptosis of rat alveolar type II cells via the PLTP\u002FTGF-β1\u002FSmad2 pathway. Int Immunopharmacol. 2015;28(1):707–14.\nMahmood MQ, Reid D, Ward C, Muller HK, Knight DA, Sohal SS, Walters EH. Transforming growth factor (TGF) beta1 and Smad signalling pathways: a likely key to EMT-associated COPD pathogenesis. Respirology (Carlton, Vic). 2017;22(1):133–40.\nGuan S, Liu Q, Han F, Gu W, Song L, Zhang Y, Guo X, Xu W. Ginsenoside Rg1 ameliorates cigarette smoke-induced airway fibrosis by suppressing the TGF-beta1\u002FSmad pathway in vivo and in vitro. Biomed Res Int. 2017;2017:6510198.\nSoltani A, Sohal SS, Reid D, Weston S, Wood-Baker R, Walters EH. Vessel-associated transforming growth factor-beta1 (TGF-beta1) is increased in the bronchial reticular basement membrane in COPD and normal smokers. PLoS One. 2012;7(6):e39736.\nIchimaru Y, Krimmer DI, Burgess JK, Black JL, Oliver BG. TGF-beta enhances deposition of perlecan from COPD airway smooth muscle. American journal of physiology Lung cellular and molecular physiology. 2012;302(3):L325–33.\nHogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004;364(9435):709–21.\nBarnes PJ. New concepts in chronic obstructive pulmonary disease. Annu Rev Med. 2003;54:113–29.\nKranenburg AR, de Boer WI, Alagappan VK, Sterk PJ, Sharma HS. Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease. Thorax. 2005;60(2):106–13.\nTanimura K, Sato S, Fuseya Y, Hasegawa K, Uemasu K, Sato A, Oguma T, Hirai T, Mishima M, Muro S. Quantitative assessment of erector spinae muscles in patients with chronic obstructive pulmonary disease. Novel chest computed tomography-derived index for prognosis. Annals of the American Thoracic Society. 2016;13(3):334–41.\nPansters NA, Langen RC, Wouters EF, Schols AM. Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling. Journal of applied physiology (Bethesda, Md : 1985). 2013;114(9):1329–39.\nLopez IP, Pineiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG. Involvement of Igf1r in bronchiolar epithelial regeneration: role during repair kinetics after selective Club cell ablation. PLoS One. 2016;11(11):e0166388.\nMa R, Gong X, Jiang H, Lin C, Chen Y, Xu X, Zhang C, Wang J, Lu W, Zhong N. Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD. International journal of chronic obstructive pulmonary disease. 2017;12:581–7.\nSpruit MA, Gosselink R, Troosters T, Kasran A, Gayan-Ramirez G, Bogaerts P, Bouillon R, Decramer M. Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I. Thorax. 2003;58(9):752–6.\nDing H, Wang H, Zhu L, Wei W. Ursolic acid ameliorates early brain injury after experimental traumatic brain injury in mice by activating the Nrf2 pathway. Neurochem Res. 2016.\nRai SN, Yadav SK, Singh D, Singh SP. Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced parkinsonian mouse model. J Chem Neuroanat. 2016;71:41–9.\nKashyap D, Sharma A, Tuli HS, Punia S, Sharma AK. Ursolic acid and Oleanolic acid: Pentacyclic Terpenoids with promising anti-inflammatory activities. Recent Patents Inflamm Allergy Drug Discov. 2016;10(1):21–33.\nWang S, Meng X, Dong Y. Ursolic acid nanoparticles inhibit cervical cancer growth in vitro and in vivo via apoptosis induction. Int J Oncol. 2017;50(4):1330–40.\nYang Y, Li C, Xiang X, Dai Z, Chang J, Zhang M, Cai H, Zhang H, Zhang M, Guo Y, et al. Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes. J Mol Cell Cardiol. 2014;67:103–11.\nDong X, Liu S, Zhang L, Yu S, Huo L, Qile M, Liu L, Yang B, Yu J. Downregulation of miR-21 is involved in direct actions of ursolic acid on the heart: implications for cardiac fibrosis and hypertrophy. Cardiovasc Ther. 2015;33(4):161–7.\nLin L, Yin Y, Hou G, Han D, Kang J, Wang Q. Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways. Pulm Pharmacol Ther. 2017;44:111–21.\nMurakami S, Takashima H, Sato-Watanabe M, Chonan S, Yamamoto K, Saitoh M, Saito S, Yoshimura H, Sugawara K, Yang J, et al. Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1. FEBS Lett. 2004;566(1–3):55–9.\nYu R, Chen JA, Xu J, Cao J, Wang Y, Thomas SS, Hu Z. Suppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease. J Cachexia Sarcopenia Muscle. 2017;8(2):327–41.\nChen Y, Hanaoka M, Chen P, Droma Y, Voelkel NF, Kubo K. Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema. American journal of physiology Lung cellular and molecular physiology. 2009;296(4):L648–56.\nLi Y, Li J, Li W, Li S, Tian Y, Lu X, Jiang S, Wang Y. Long-term effects of three Tiao-Bu Fei-Shen therapies on NF-κB\u002FTGF-β1\u002Fsmad2 signaling in rats with chronic obstructive pulmonary disease. BMC Complement Altern Med. 2014;14:140.\nLeppäranta O, Myllärniemi M, Salmenkivi K, Kinnula V, Keski-Oja J, Koli K. Reduced phosphorylation of the TGF-Beta signal transducer Smad2 in emphysematous human lung. COPD. 2009;6(4):234–41.\nShin H, Ryu E, Oh E, Kang D. Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells. Lab Investig. 2015;95(10):1157–73.\nShah P, Dupre T, Siskind L, Beverly L. Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress. Oncotarget. 2017;8(14):22625–39.\nTang X, Liang X, Li M, Guo T, Duan N, Wang Y, Rong G, Yang L, Zhang S, Zhang J. ATF6 pathway of unfolded protein response mediates advanced oxidation protein product-induced hypertrophy and epithelial-to-mesenchymal transition in HK-2 cells. Mol Cell Biochem. 2015;407(1–2):197–207.\nTanjore H, Cheng D, Degryse A, Zoz D, Abdolrasulnia R, Lawson W, Blackwell T. Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J Biol Chem. 2015;290(6):3277.\nLiang X, Duan N, Wang Y, Shu S, Xiang X, Guo T, Yang L, Zhang S, Tang X, Zhang J. Advanced oxidation protein products induce endothelial-to-mesenchymal transition in human renal glomerular endothelial cells through induction of endoplasmic reticulum stress. J Diabetes Complicat. 2016;30(4):573–9.\nYing R, Wang X, Yang Y, Gu Z, Mai J, Qiu Q, Chen Y, Wang J. Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway. Life Sci. 2016;144:208–17.",{"VOID":326},"10.1186\u002Fs12890-019-0826-6","2024-12-15T01:41:17.790+00:00",[181],"https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-019-0826-6",[331,346,359,372,385,398],{"id":332,"sortIndex":19,"researcher":18,"roles":333,"affiliations":334,"properties":343,"displayName":345,"givenName":18,"familyName":18},"4c752a47-68a6-4a8b-8bab-06880134a4ee",[187],[335],{"id":336,"sortIndex":19,"affiliation":337,"properties":18},"8fb73082-9a8b-4d0b-9ff9-0f2d8516e809",{"id":336,"createTime":18,"updateTime":18,"relativeEntities":338,"slug":18,"properties":339,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":342,"statistic":18},[],{"title":340},{"VI":341},"Institute of Respiratory Disease, The First Hospital of China Medical University, Shenyang, China",[],{"title":344},{"VI":345},"Li Lin",{"id":347,"sortIndex":137,"researcher":18,"roles":348,"affiliations":349,"properties":356,"displayName":358,"givenName":18,"familyName":18},"eb962afb-fce2-41e7-a488-03cd02aa3a24",[187],[350],{"id":336,"sortIndex":19,"affiliation":351,"properties":18},{"id":336,"createTime":18,"updateTime":18,"relativeEntities":352,"slug":18,"properties":353,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":355,"statistic":18},[],{"title":354},{"VI":341},[],{"title":357},{"VI":358},"Gang Hou",{"id":360,"sortIndex":217,"researcher":18,"roles":361,"affiliations":362,"properties":369,"displayName":371,"givenName":18,"familyName":18},"f8bd5ad9-339f-4d62-abd6-5d05980ac647",[187],[363],{"id":336,"sortIndex":19,"affiliation":364,"properties":18},{"id":336,"createTime":18,"updateTime":18,"relativeEntities":365,"slug":18,"properties":366,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":368,"statistic":18},[],{"title":367},{"VI":341},[],{"title":370},{"VI":371},"Dan Han",{"id":373,"sortIndex":96,"researcher":18,"roles":374,"affiliations":375,"properties":382,"displayName":384,"givenName":18,"familyName":18},"b9f4cb14-7f00-4a43-9f3d-83a393afafd2",[187],[376],{"id":336,"sortIndex":19,"affiliation":377,"properties":18},{"id":336,"createTime":18,"updateTime":18,"relativeEntities":378,"slug":18,"properties":379,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":381,"statistic":18},[],{"title":380},{"VI":341},[],{"title":383},{"VI":384},"Yan Yin",{"id":386,"sortIndex":95,"researcher":18,"roles":387,"affiliations":388,"properties":395,"displayName":397,"givenName":18,"familyName":18},"648d429c-a8c9-420f-b301-1d3895268894",[187],[389],{"id":336,"sortIndex":19,"affiliation":390,"properties":18},{"id":336,"createTime":18,"updateTime":18,"relativeEntities":391,"slug":18,"properties":392,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":394,"statistic":18},[],{"title":393},{"VI":341},[],{"title":396},{"VI":397},"Jian Kang",{"id":399,"sortIndex":400,"researcher":18,"roles":401,"affiliations":402,"properties":409,"displayName":411,"givenName":18,"familyName":18},"c186b902-e6c0-4c9d-82ee-050d70702a11",5,[187],[403],{"id":336,"sortIndex":19,"affiliation":404,"properties":18},{"id":336,"createTime":18,"updateTime":18,"relativeEntities":405,"slug":18,"properties":406,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":408,"statistic":18},[],{"title":407},{"VI":341},[],{"title":410},{"VI":411},"Qiuyue Wang",{"url":329,"publisher":413,"properties":454},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":414,"slug":10,"properties":415,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":418,"manageAffiliations":423,"indexDatabases":434,"url":18,"thumbnailPath":18,"statistic":449,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":416,"eissn":417},{"EN":13},{"VOID":15},[419],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":420,"label":421,"description":422,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[424,429],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":425,"slug":18,"properties":426,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":428,"statistic":18},[],{"title":427},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":430,"slug":18,"properties":431,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":433,"statistic":18},[],{"title":432},{"EN":40},[],[435,442],{"id":61,"indexDatabase":436,"url":72,"indexYears":73,"academicFieldIds":441,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":437,"label":438,"description":439,"key":69,"publicationTags":440,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":443,"url":57,"indexYears":18,"academicFieldIds":448,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":444,"label":445,"description":446,"key":53,"publicationTags":447,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":450,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":451,"totalCitation":116,"totalCitationByYear":452,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":453,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":455,"volume":457},{"VOID":456},"1-11",{"VOID":458},"19","2019-06-06",2019,[55,76],{"id":463,"createTime":464,"updateTime":465,"relativeEntities":466,"slug":467,"properties":468,"entityType":176,"verifyStatus":177,"verifyTime":480,"verifyNote":179,"languages":481,"translateLanguages":483,"viewCount":19,"primaryUrl":484,"fullTextUrl":18,"authors":485,"publicationType":259,"publisherRelationship":590,"citationCount":19,"citationInfo":632,"publishDate":18,"publishYear":18,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":634,"openAccess":18,"references":635,"isForceReanalyzing":310},"e201d4af-29ec-4234-b33a-7a9ea25bdd3b","2024-04-11T20:38:23.893+00:00","2026-09-05T09:21:44.136+00:00",[],"Association-of-serum-vitamin-C-levels-with-Asthma-in-adults-results-of-NHANES-2003-2006-and-mendelian-randomization-study",{"openalex":469,"abstract":471,"title":473,"pm":476,"doi":478},{"VOID":470},"W4390495591",{"EN":472},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\n                \u003Cjats:title>Background\u003C\u002Fjats:title>\n                \u003Cjats:p>The protective effect of vitamin C as an antioxidant against asthma in adults remains controversial. This study used an observational study and Mendelian randomization (MR) analysis to investigate the association between adult asthma and serum vitamin C levels.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Methods\u003C\u002Fjats:title>\n                \u003Cjats:p>Using information from the National Health and Nutrition Examination Survey (NHANES) 2003–2006, we carried out an observational study. A multivariate logistic regression model was employed to examine the connection between adult asthma and serum vitamin C levels. We used the inverse-variance weighted (IVW) method of MR analysis as the primary method to analyze the causal effect of serum vitamin C levels on asthma in adults.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Results\u003C\u002Fjats:title>\n                \u003Cjats:p>A total of 8,504 participants were included in the observational study, including 639 in the asthma group and 7,865 in the non-asthma group. Before sample weighting, serum vitamin C was associated with a reduced risk of asthma in adults (OR = 0.798, 95% CI: 0.673–0.945, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.009). After sample weighting, serum vitamin C was not associated with adult asthma risk (OR = 0.829, 95% CI: 0.660 ~ 1.042, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.104). MR analysis showed no causal relationship between serum vitamin C and adult asthma in either the UK Biobank (OR = 0.957, 95% CI: 0.871 ~ 1.053, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.370) or FinnGen (OR = 0.973, 95% CI: 0.824 ~ 1.149, \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.750) cohorts.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n                \u003Cjats:p>Our study did not support a causal association between serum vitamin C levels and adult asthma risk. The relationship between serum vitamin C and adult asthma requires further research.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>",{"EN":474,"VI":475},"Association of serum vitamin C levels with Asthma in adults: results of NHANES 2003–2006 and mendelian randomization study","Mối liên quan giữa nồng độ vitamin C huyết thanh với bệnh hen ở người trưởng thành: kết quả từ NHANES 2003–2006 và nghiên cứu phân ngẫu nhiên Mendel",{"VOID":477},"38166915",{"VOID":479},"10.1186\u002Fs12890-023-02821-w","2025-02-23T15:50:54.036+00:00",[482],"EN",[181],"https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-023-02821-w",[486,505,522,539,556,573],{"id":487,"sortIndex":19,"researcher":18,"roles":488,"affiliations":489,"properties":498,"displayName":502,"givenName":18,"familyName":18},"b48b7ca1-838d-4e8e-93d8-55be8bf196c0",[],[490],{"id":491,"sortIndex":19,"affiliation":492,"properties":18},"caadae99-ff8b-4078-8c9a-3034a15aeb4d",{"id":491,"createTime":18,"updateTime":18,"relativeEntities":493,"slug":18,"properties":494,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":497,"statistic":18},[],{"title":495},{"EN":496},"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of the Army Medical University, Chongqing, China",[],{"orcid":499,"title":501,"openalex":503},{"VOID":500},"https:\u002F\u002Forcid.org\u002F0000-0002-3169-6034",{"EN":502},"Kang Wang",{"VOID":504},"A5039679140",{"id":506,"sortIndex":137,"researcher":18,"roles":507,"affiliations":508,"properties":515,"displayName":519,"givenName":18,"familyName":18},"71ba1fe3-eec5-469b-9bcc-9e76b221c2d1",[],[509],{"id":491,"sortIndex":19,"affiliation":510,"properties":18},{"id":491,"createTime":18,"updateTime":18,"relativeEntities":511,"slug":18,"properties":512,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":514,"statistic":18},[],{"title":513},{"EN":496},[],{"orcid":516,"title":518,"openalex":520},{"VOID":517},"https:\u002F\u002Forcid.org\u002F0000-0002-5844-497X",{"EN":519},"Li Zhao",{"VOID":521},"A5082711879",{"id":523,"sortIndex":217,"researcher":18,"roles":524,"affiliations":525,"properties":532,"displayName":536,"givenName":18,"familyName":18},"381b068c-4e54-4481-94c5-d754b3a662f5",[],[526],{"id":491,"sortIndex":19,"affiliation":527,"properties":18},{"id":491,"createTime":18,"updateTime":18,"relativeEntities":528,"slug":18,"properties":529,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":531,"statistic":18},[],{"title":530},{"EN":496},[],{"orcid":533,"title":535,"openalex":537},{"VOID":534},"https:\u002F\u002Forcid.org\u002F0000-0002-2799-7360",{"EN":536},"Haitao Luo",{"VOID":538},"A5024577852",{"id":540,"sortIndex":96,"researcher":18,"roles":541,"affiliations":542,"properties":549,"displayName":553,"givenName":18,"familyName":18},"ee65e127-a04c-4d7d-9dd4-8b8bdb44ec19",[],[543],{"id":491,"sortIndex":19,"affiliation":544,"properties":18},{"id":491,"createTime":18,"updateTime":18,"relativeEntities":545,"slug":18,"properties":546,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":548,"statistic":18},[],{"title":547},{"EN":496},[],{"orcid":550,"title":552,"openalex":554},{"VOID":551},"https:\u002F\u002Forcid.org\u002F0009-0006-1999-9346",{"EN":553},"Caixia Deng",{"VOID":555},"A5011076504",{"id":557,"sortIndex":95,"researcher":18,"roles":558,"affiliations":559,"properties":566,"displayName":570,"givenName":18,"familyName":18},"ef1c20f1-772a-4b58-bf1f-ee92cd59b3a0",[],[560],{"id":491,"sortIndex":19,"affiliation":561,"properties":18},{"id":491,"createTime":18,"updateTime":18,"relativeEntities":562,"slug":18,"properties":563,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":565,"statistic":18},[],{"title":564},{"EN":496},[],{"orcid":567,"title":569,"openalex":571},{"VOID":568},"https:\u002F\u002Forcid.org\u002F0000-0001-9807-8049",{"EN":570},"Liang Gong",{"VOID":572},"A5024329926",{"id":574,"sortIndex":400,"researcher":18,"roles":575,"affiliations":576,"properties":583,"displayName":587,"givenName":18,"familyName":18},"00476a06-7101-4496-9081-84fdc688e3e2",[],[577],{"id":491,"sortIndex":19,"affiliation":578,"properties":18},{"id":491,"createTime":18,"updateTime":18,"relativeEntities":579,"slug":18,"properties":580,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":582,"statistic":18},[],{"title":581},{"EN":496},[],{"orcid":584,"title":586,"openalex":588},{"VOID":585},"https:\u002F\u002Forcid.org\u002F0009-0001-6750-7266",{"EN":587},"Zhujun Chen",{"VOID":589},"A5008346861",{"url":18,"publisher":591,"properties":18},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":592,"slug":10,"properties":593,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":596,"manageAffiliations":601,"indexDatabases":612,"url":18,"thumbnailPath":18,"statistic":627,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":594,"eissn":595},{"EN":13},{"VOID":15},[597],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":598,"label":599,"description":600,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[602,607],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":603,"slug":18,"properties":604,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":606,"statistic":18},[],{"title":605},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":608,"slug":18,"properties":609,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":611,"statistic":18},[],{"title":610},{"EN":40},[],[613,620],{"id":61,"indexDatabase":614,"url":72,"indexYears":73,"academicFieldIds":619,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":615,"label":616,"description":617,"key":69,"publicationTags":618,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":621,"url":57,"indexYears":18,"academicFieldIds":626,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":622,"label":623,"description":624,"key":53,"publicationTags":625,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":628,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":629,"totalCitation":116,"totalCitationByYear":630,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":631,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"total":19,"publishYear":18,"statisticByYear":633},{},[],[636,640,643,647,651,655,659,663,667,671,675,679,683,687,691,695,699,703,707,711,715,719,722,726,730,734,738,741,745],{"id":18,"text":637,"url":18,"identifiers":638},"Miller RL, Grayson MH, Strothman K. Advances in Asthma: New understandings of Asthma’s natural history, risk factors, underlying mechanisms, and clinical management. J Allergy Clin Immunol. 2021;148(6):1430–41.",{"doi":639},"10.1016\u002Fj.jaci.2021.10.001",{"id":18,"text":641,"url":18,"identifiers":642},"GBD 2019 Chronic Respiratory Diseases Collaborators. Global burden of chronic Respiratory Diseases and risk factors, 1990–2019: an update from the global burden of Disease Study 2019. EClinicalMedicine. 2023;59:101936.",{},{"id":18,"text":644,"url":18,"identifiers":645},"Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, et al. Prevalence, risk factors, and management of Asthma in China: a national cross-sectional study. Lancet. 2019;394(10196):407–18.",{"doi":646},"10.1016\u002FS0140-6736(19)31147-X",{"id":18,"text":648,"url":18,"identifiers":649},"Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 2015;4:180–3.",{"doi":650},"10.1016\u002Fj.redox.2015.01.002",{"id":18,"text":652,"url":18,"identifiers":653},"James BN, Oyeniran C, Sturgill JL, Newton J, Martin RK, Bieberich E, et al. Ceramide in apoptosis and oxidative stress in allergic inflammation and Asthma. J Allergy Clin Immunol. 2021;147(5):1936–48e9.",{"doi":654},"10.1016\u002Fj.jaci.2020.10.024",{"id":18,"text":656,"url":18,"identifiers":657},"Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with Asthma. Respir Med. 2007;101(8):1770–8.",{"doi":658},"10.1016\u002Fj.rmed.2007.02.014",{"id":18,"text":660,"url":18,"identifiers":661},"Doseděl M, Jirkovský E, Macáková K, Krčmová LK, Javorská L, Pourová J, et al. Vitamin C-Sources, physiological role, Kinetics, Deficiency, Use, Toxicity, and determination. Nutrients. 2021;13(2):615.",{"doi":662},"10.3390\u002Fnu13020615",{"id":18,"text":664,"url":18,"identifiers":665},"Kaur B, Rowe BH, Arnold E. Vitamin C supplementation for Asthma. Cochrane Database Syst Rev. 2009;2009(1). CD000993.",{"doi":666},"10.1002\u002F14651858.CD000993.pub3",{"id":18,"text":668,"url":18,"identifiers":669},"Ahluwalia N, Dwyer J, Terry A, Moshfegh A, Johnson C. Update on NHANES Dietary Data: Focus on Collection, Release, Analytical considerations, and uses to inform Public Policy. Adv Nutr. 2016;7(1):121–34.",{"doi":670},"10.3945\u002Fan.115.009258",{"id":18,"text":672,"url":18,"identifiers":673},"Emdin CA, Khera AV, Kathiresan S, Mendelian Randomization. JAMA. 2017;318(19):1925–6.",{"doi":674},"10.1001\u002Fjama.2017.17219",{"id":18,"text":676,"url":18,"identifiers":677},"Burgess S, Thompson SG. Avoiding bias from weak instruments in mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–64.",{"doi":678},"10.1093\u002Fije\u002Fdyr036",{"id":18,"text":680,"url":18,"identifiers":681},"Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, et al. Physical activity and risks of breast and Colorectal cancer: a mendelian randomisation analysis. Nat Commun. 2020;11(1):597.",{"doi":682},"10.1038\u002Fs41467-020-14389-8",{"id":18,"text":684,"url":18,"identifiers":685},"Zheng JS, Luan J, Sofianopoulou E, Imamura F, Stewart ID, Day FR, et al. Plasma Vitamin C and type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European populations. Diabetes Care. 2021;44(1):98–106.",{"doi":686},"10.2337\u002Fdc20-1328",{"id":18,"text":688,"url":18,"identifiers":689},"Valette K, Li Z, Bon-Baret V, Chignon A, Bérubé JC, Eslami A, et al. Prioritization of candidate causal genes for Asthma in susceptibility loci derived from UK Biobank. Commun Biol. 2021;4(1):700.",{"doi":690},"10.1038\u002Fs42003-021-02227-6",{"id":18,"text":692,"url":18,"identifiers":693},"Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol. 2017;46(6):1985–98.",{"doi":694},"10.1093\u002Fije\u002Fdyx102",{"id":18,"text":696,"url":18,"identifiers":697},"Bowden J, Del Greco MF, Minelli C, Davey Smith G, Sheehan N, Thompson J. A framework for the investigation of pleiotropy in two-sample summary data mendelian randomization. Stat Med. 2017;36(11):1783–802.",{"doi":698},"10.1002\u002Fsim.7221",{"id":18,"text":700,"url":18,"identifiers":701},"Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25.",{"doi":702},"10.1093\u002Fije\u002Fdyv080",{"id":18,"text":704,"url":18,"identifiers":705},"Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and Diseases. Nat Genet. 2018;50(5):693–8.",{"doi":706},"10.1038\u002Fs41588-018-0099-7",{"id":18,"text":708,"url":18,"identifiers":709},"Camarena V, Wang G. The epigenetic role of vitamin C in health and Disease. Cell Mol Life Sci. 2016;73(8):1645–58.",{"doi":710},"10.1007\u002Fs00018-016-2145-x",{"id":18,"text":712,"url":18,"identifiers":713},"Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in skin health. Nutrients. 2017;9(8):866.",{"doi":714},"10.3390\u002Fnu9080866",{"id":18,"text":716,"url":18,"identifiers":717},"Ben Anes A, Ben Nasr H, Fetoui H, Bchir S, Chahdoura H, Yacoub S, et al. Alteration in systemic markers of oxidative and antioxidative status in Tunisian patients with Asthma: relationships with clinical severity and airflow limitation. J Asthma. 2016;53(3):227–37.",{"doi":718},"10.3109\u002F02770903.2015.1087559",{"id":18,"text":720,"url":18,"identifiers":721},"Shidfar F, Baghai N, Keshavarz A, Ameri A, Shidfar S. Comparison of plasma and leukocyte vitamin C status between asthmatic and healthy subjects. East Mediterr Health J. 2005;11(1–2):87–95.",{},{"id":18,"text":723,"url":18,"identifiers":724},"Picado C, Deulofeu R, Lleonart R, Agustí M, Mullol J, Quintó L, et al. Dietary micronutrients\u002Fantioxidants and their relationship with bronchial Asthma severity. Allergy. 2001;56(1):43–9.",{"doi":725},"10.1034\u002Fj.1398-9995.2001.00793.x",{"id":18,"text":727,"url":18,"identifiers":728},"Uysalol M, Mutlu LC, Saracoglu GV, Karasu E, Guzel S, Kayaoglu S, et al. Childhood Asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them? Ital J Pediatr. 2013;39:78.",{"doi":729},"10.1186\u002F1824-7288-39-78",{"id":18,"text":731,"url":18,"identifiers":732},"Beckhaus AA, Garcia-Marcos L, Forno E, Pacheco-Gonzalez RM, Celedón JC, Castro-Rodriguez JA. Maternal nutrition during pregnancy and risk of Asthma, wheeze, and atopic Diseases during childhood: a systematic review and meta-analysis. Allergy. 2015;70(12):1588–604.",{"doi":733},"10.1111\u002Fall.12729",{"id":18,"text":735,"url":18,"identifiers":736},"Hysinger EB, Roizen JD, Mentch FD, Vazquez L, Connolly JJ, Bradfield JP, et al. Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric Asthma. J Allergy Clin Immunol. 2016;138(6):1747–9e4.",{"doi":737},"10.1016\u002Fj.jaci.2016.06.056",{"id":18,"text":739,"url":18,"identifiers":740},"Gans MD, Gavrilova T. Understanding the immunology of Asthma: pathophysiology, biomarkers, and treatments for Asthma endotypes. Paediatr Respir Rev. 2020;36:118–27.",{},{"id":18,"text":742,"url":18,"identifiers":743},"McEvoy CT, Schilling D, Clay N, Jackson K, Go MD, Spitale P, et al. Vitamin C supplementation for pregnant Smoking women and pulmonary function in their newborn infants: a randomized clinical trial. JAMA. 2014;311(20):2074–82.",{"doi":744},"10.1001\u002Fjama.2014.5217",{"id":18,"text":746,"url":18,"identifiers":747},"Nakamura K, Wada K, Sahashi Y, Tamai Y, Tsuji M, Watanabe K, et al. Associations of intake of antioxidant vitamins and fatty acids with Asthma in pre-school children. Public Health Nutr. 2013;16(11):2040–5.",{"doi":748},"10.1017\u002FS1368980012004363",{"id":750,"createTime":751,"updateTime":752,"relativeEntities":753,"slug":754,"properties":755,"entityType":176,"verifyStatus":177,"verifyTime":766,"verifyNote":179,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":767,"fullTextUrl":18,"authors":768,"publicationType":259,"publisherRelationship":865,"citationCount":19,"citationInfo":912,"publishDate":915,"publishYear":913,"citationAnalyzeStatus":916,"lastCitationAnalyze":917,"indexDatabases":918,"openAccess":18,"references":18,"isForceReanalyzing":310},"8859ff42-4354-49fb-8172-60e718ee4d82","2024-01-01T17:02:50.675+00:00","2026-07-30T00:40:16.881+00:00",[],"The-incidence-of-interstitial-lung-disease-1995-2005-a-Danish-nationwide-population-based-study",{"abstract":756,"title":758,"gsPaper":760,"references":762,"doi":764},{"EN":757},"Current data on incidence of interstitial lung diseases (ILDs) are sparse and concerns about an increasing trend have been raised. We examined incidence rates (IRs) of ILDs and changes in IRs between 1995 and 2005. All persons with a first-time hospital discharge or outpatient diagnosis of ILD were identified through the Danish National Registry of Patients, which covers all Danish hospitals. Crude and age-standardised IRs were computed for ILD overall, as well as stratified by ILD subcategories. A total of 21,765 patients with ILD were identified. Between 1995 and 1998 the overall standardised IR of ILD decreased from 27.14 (95% CI 25.82–28.46) per 100,000 person-years to 19.36 (95% CI 18.26–20.46) per 100,000 person-years. After 1998 the IR increased considerably, peaking at 34.34 (95% CI 32.84–35.85) per 100,000 person-years in 2002. Subsequently there was a slight decrease. The highest IR was observed in the non-specific category \"Respiratory disorders in diseases classified elsewhere\". By ILD subcategory, the greatest average increase during the study period was observed in \"Respiratory disorders in diseases classified elsewhere\". The incidence rate of ILD in Denmark increased during the study period, most pronounced for ILDs associated with systemic diseases.",{"EN":759},"The incidence of interstitial lung disease 1995–2005: a Danish nationwide population-based study",{"VOID":761},"[\"1437867724850608285\"]",{"VOID":763},"Behr J, Ryu JH: Pulmonary hypertension in interstitial lung disease. Eur Respir J. 2008, 31: 1357-67. 10.1183\u002F09031936.00171307.\nAmerican Thoracic Society: Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med. 2000, 161 (2 Pt 1): 646-664.\nRaghu G, Nyberg F, Morgan G: The epidemiology of interstitial lung disease and its association with lung cancer. Br J Cancer. 2004, 91 (Suppl 2): S3-10. 10.1038\u002Fsj.bjc.6602061.\nBRITISH THORACIC SOCIETY and STANDARDS OF CARE COMMMITTEE: The Diagnosis, Assessment and Treatment of Diffuse Parenchymal Lung Disease in Adults. Thorax. 1999, 54 Suppl 1: S1-14.\nLopez-Campos JL, Rodriguez-Becerra E, Neumosur Task Group; Registry of Interstitial Lung Diseases: Incidence of interstitial lung diseases in the south of Spain 1998–2000: the RENIA study. Eur J Epidemiol. 2004, 19: 155-161. 10.1023\u002FB:EJEP.0000017660.18541.83.\nCoultas DB, Zumwalt RE, Black WC, Sobonya RE: The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med. 1994, 150: 967-972.\nRoelandt M, Demedts M, Callebaut W, Coolen D, Slabbynck H, Bockaert J, Kips J, Brie J, Ulburghs M, De Boeck K: epidemiology of interstitial lung disease (ILD) in flanders: registration by pneumologists in 1992–1994. Working group on ILD, VRGT. Vereniging voor Respiratoire Gezondheidszorg en Tuberculosebestrijding. Acta Clin Belg. 1995, 50: 260-268.\nSchweisfurth H: [Report by the Scientific Working Group for Therapy of Lung Diseases: German Fibrosis Register with initial results]. Pneumologie. 1996, 50: 899-901.\nThomeer MJ, Costabe U, Rizzato G, Poletti V, Demedts M: Comparison of registries of interstitial lung diseases in three European countries. Eur Respir J Suppl. 2001, 32: 114s-118s.\nXaubet A, Ancochea J, Blanquer R, Montero C, Morell F, Rodríguez Becerra E, Sueiro A, Villena V, Grupo de Investigación en Enfermedades Pulmonares Intersticiales Difusas. Area de Técnicas y Transplante. SEPAR: Report on the incidence of interstitial lung diseases in Spain. Sarcoidosis Vasc Diffuse Lung Dis. 2004, 21: 64-70.\nFrank L, Epidemiology: When an entire country is a cohort. Science. 2000, 287: 2398-2399. 10.1126\u002Fscience.287.5462.2398.\nChristensen S, Pedersen L, Grijota M, Kornum JB, Beiderbeck A, Sørensen HT: Incidence of interstitial pneumonitis among breast cancer patients: a 10-year Danish population-based cohort study. Br J Cancer. 2008, 98: 1870-1875. 10.1038\u002Fsj.bjc.6604393.\nSørensen HT, Regional administrative health registers as a resource in clinical epidemiology: A study of options, strengths, limitations and data quality provided with examples of use. Int J Risk Safety Med. 1997, 10: 1-22.\nAmerican Thoracic Society, European Respiratory Society: International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002, 165: 277-304.\nDirksen A, Larsson A, Mortensen J, Milman N, Faurschou P, Tønnesen P, Lange P, Vestbo J, Mosbech H, Iversen M, Arendrup H, Harving H, Clementsen P, Viskum K, Rasmussen FV, Lungesygdomme: Medicinsk Kompendium. Edited by: Hansen EH, Haunsø S, Schaffalitzky de Muckadell OB. 2004, Copenhagen: Nyt Nordisk Forlag Arnold Busck, 1286-1432. 16\nOlson AL, Swigris JJ, Lezotte DC, Norris JM, Wilson CG, Brown KK: Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. Am J Respir Crit Care Med. 2007, 176: 277-284. 10.1164\u002Frccm.200701-044OC.\nRaghu G, Weycker D, Edelsberg J, Bradford WZ, Oster G: Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006, 174: 810-816. 10.1164\u002Frccm.200602-163OC.\nThe pre-publication history for this paper can be accessed here:http:\u002F\u002Fwww.biomedcentral.com\u002F1471-2466\u002F8\u002F24\u002Fprepub",{"VOID":765},"10.1186\u002F1471-2466-8-24","2024-09-04T22:36:52.862+00:00","https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002F1471-2466-8-24",[769,784,797,810,823,836,851],{"id":770,"sortIndex":19,"researcher":18,"roles":771,"affiliations":772,"properties":781,"displayName":783,"givenName":18,"familyName":18},"b08485f4-2334-4333-a14d-004a49ea002d",[187],[773],{"id":774,"sortIndex":19,"affiliation":775,"properties":18},"995630a2-161c-48e5-a1c7-3e521bdb6f7d",{"id":774,"createTime":18,"updateTime":18,"relativeEntities":776,"slug":18,"properties":777,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":780,"statistic":18},[],{"title":778},{"VI":779},"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark",[],{"title":782},{"VI":783},"Jette B Kornum",{"id":785,"sortIndex":137,"researcher":18,"roles":786,"affiliations":787,"properties":794,"displayName":796,"givenName":18,"familyName":18},"3be9f626-dd1e-411e-9937-2010f06e6879",[187],[788],{"id":774,"sortIndex":19,"affiliation":789,"properties":18},{"id":774,"createTime":18,"updateTime":18,"relativeEntities":790,"slug":18,"properties":791,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":793,"statistic":18},[],{"title":792},{"VI":779},[],{"title":795},{"VI":796},"Steffen Christensen",{"id":798,"sortIndex":217,"researcher":18,"roles":799,"affiliations":800,"properties":807,"displayName":809,"givenName":18,"familyName":18},"785a2ef8-77de-487b-9acf-fee08e6859b9",[187],[801],{"id":774,"sortIndex":19,"affiliation":802,"properties":18},{"id":774,"createTime":18,"updateTime":18,"relativeEntities":803,"slug":18,"properties":804,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":806,"statistic":18},[],{"title":805},{"VI":779},[],{"title":808},{"VI":809},"Miriam Grijota",{"id":811,"sortIndex":96,"researcher":18,"roles":812,"affiliations":813,"properties":820,"displayName":822,"givenName":18,"familyName":18},"fdabb176-ad35-485e-aa16-95f209eaa083",[187],[814],{"id":774,"sortIndex":19,"affiliation":815,"properties":18},{"id":774,"createTime":18,"updateTime":18,"relativeEntities":816,"slug":18,"properties":817,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":819,"statistic":18},[],{"title":818},{"VI":779},[],{"title":821},{"VI":822},"Lars Pedersen",{"id":824,"sortIndex":95,"researcher":18,"roles":825,"affiliations":826,"properties":833,"displayName":835,"givenName":18,"familyName":18},"fd33f991-cb7b-4d29-99a5-c45a2bb507e5",[187],[827],{"id":774,"sortIndex":19,"affiliation":828,"properties":18},{"id":774,"createTime":18,"updateTime":18,"relativeEntities":829,"slug":18,"properties":830,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":832,"statistic":18},[],{"title":831},{"VI":779},[],{"title":834},{"VI":835},"Pia Wogelius",{"id":837,"sortIndex":400,"researcher":18,"roles":838,"affiliations":839,"properties":848,"displayName":850,"givenName":18,"familyName":18},"de46bb8f-b44f-4d22-bcbd-e01f52586c3a",[187],[840],{"id":841,"sortIndex":19,"affiliation":842,"properties":18},"d1942ee9-b69c-4865-88ab-911971308f03",{"id":841,"createTime":18,"updateTime":18,"relativeEntities":843,"slug":18,"properties":844,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":847,"statistic":18},[],{"title":845},{"VI":846},"Worldwide Epidemiology, GlaxoSmithKline, Greenford, UK",[],{"title":849},{"VI":850},"Annette Beiderbeck",{"id":852,"sortIndex":853,"researcher":18,"roles":854,"affiliations":855,"properties":862,"displayName":864,"givenName":18,"familyName":18},"8d762742-7bc1-42d1-b1d4-938b5ad87e6e",6,[187],[856],{"id":774,"sortIndex":19,"affiliation":857,"properties":18},{"id":774,"createTime":18,"updateTime":18,"relativeEntities":858,"slug":18,"properties":859,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":861,"statistic":18},[],{"title":860},{"VI":779},[],{"title":863},{"VI":864},"Henrik Toft Sørensen",{"url":767,"publisher":866,"properties":907},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":867,"slug":10,"properties":868,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":871,"manageAffiliations":876,"indexDatabases":887,"url":18,"thumbnailPath":18,"statistic":902,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":869,"eissn":870},{"EN":13},{"VOID":15},[872],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":873,"label":874,"description":875,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[877,882],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":878,"slug":18,"properties":879,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":881,"statistic":18},[],{"title":880},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":883,"slug":18,"properties":884,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":886,"statistic":18},[],{"title":885},{"EN":40},[],[888,895],{"id":61,"indexDatabase":889,"url":72,"indexYears":73,"academicFieldIds":894,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":890,"label":891,"description":892,"key":69,"publicationTags":893,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":896,"url":57,"indexYears":18,"academicFieldIds":901,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":897,"label":898,"description":899,"key":53,"publicationTags":900,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":903,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":904,"totalCitation":116,"totalCitationByYear":905,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":906,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":908,"volume":910},{"VOID":909},"1-7",{"VOID":911},"8",{"total":19,"publishYear":913,"statisticByYear":914},2008,{},"2008-11-04","DONE_ANALYZE_CITATION","2026-07-30T00:40:16.880+00:00",[55,76],{"id":920,"createTime":921,"updateTime":922,"relativeEntities":923,"slug":924,"properties":925,"entityType":176,"verifyStatus":177,"verifyTime":936,"verifyNote":179,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":937,"fullTextUrl":18,"authors":938,"publicationType":259,"publisherRelationship":1025,"citationCount":19,"citationInfo":1072,"publishDate":1075,"publishYear":1073,"citationAnalyzeStatus":916,"lastCitationAnalyze":1076,"indexDatabases":1077,"openAccess":18,"references":18,"isForceReanalyzing":310},"36a4a072-5e8d-4bb3-80bc-3409be1ba6b5","2023-11-26T23:18:08.536+00:00","2026-07-29T23:38:44.310+00:00",[],"Symptoms-impacts-and-suitability-of-the-Pulmonary-Arterial-Hypertension-Symptoms-and-Impact-PAH-SYMPACT-questionnaire-in-patients-with-sarcoidosis-associated-pulmonary-hypertension-SAPH-a-qualitative-interview-study",{"abstract":926,"title":928,"gsPaper":930,"references":932,"doi":934},{"EN":927},"Sarcoidosis-associated pulmonary hypertension (SAPH) is a prevalent and serious complication of sarcoidosis. No SAPH-specific self-report instruments for assessing SAPH symptoms and their impact on patients are available to date. This study sought to determine whether the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT™) questionnaire is suitable for use in patients with SAPH. Patients diagnosed with SAPH participated in qualitative one-on-one telephone interviews to better understand SAPH symptoms and their impacts on patients’ lives and to determine the appropriateness of the PAH-SYMPACT™ for use in patients with SAPH. The interviews comprised concept elicitation, completion of the PAH-SYMPACT™, and cognitive debriefing. Interview transcripts were analyzed by content analysis. Eleven patients with SAPH were interviewed between August 2019 and June 2020. In the concept elicitation, all 11 participants endorsed shortness of breath and nine participants (82%) rated it as their “most bothersome or severe” symptom. Impacts endorsed by all 11 participants were difficulty walking uphill or up stairs and difficulty in performing daily activities. Cognitive debriefing indicated that the PAH-SYMPACT™ items were relevant and understandable to most participants and reflected their experiences of SAPH. Participants indicated that no key symptoms or impacts of SAPH were missing. They also reported that the PAH-SYMPACT™ instructions and response options were clear, and that it would be feasible to complete the 11 symptom items and one oxygen use item as part of their daily schedule. This study suggests the PAH-SYMPACT™ is suitable for assessing symptoms and their impact in patients with SAPH. However, larger longitudinal studies are needed to confirm that it is fit for use in this patient population and that it can be used to reliably detect temporal changes in patients’ symptom status. Trial registration Not applicable.",{"EN":929},"Symptoms, impacts, and suitability of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT™) questionnaire in patients with sarcoidosis-associated pulmonary hypertension (SAPH): a qualitative interview study",{"VOID":931},"[\"16273911675812194731\"]",{"VOID":933},"Huitema MP, Grutters JC, Rensing B, Reesink HJ, Post MC. Pulmonary hypertension complicating pulmonary sarcoidosis. Neth Heart J. 2016;24(6):390–9.\nShorr AF, Helman DL, Davies DB, Nathan SD. Pulmonary hypertension in advanced sarcoidosis: epidemiology and clinical characteristics. Eur Respir J. 2005;25(5):783–8.\nSimonneau G, Robbins IM, Beghetti M, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2009;54(suppl 1):S43–54.\nBaughman RP, Teirstein AS, Judson MA, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1885–9.\nAryal S, Nathan SD. Contemporary optimized practice in the management of pulmonary sarcoidosis. Ther Adv Respir Dis. 2019;13:1753466619868935.\nPatterson KC, Strek ME. Pulmonary fibrosis in sarcoidosis. Clinical features and outcomes. Ann Am Thorac Soc. 2013;10(4):362–70.\nBourbonnais JM, Samavati L. Clinical predictors of pulmonary hypertension in sarcoidosis. Eur Respir J. 2008;32(2):296–302.\nHanda T, Nagai S, Miki S, et al. Incidence of pulmonary hypertension and its clinical relevance in patients with sarcoidosis. Chest. 2006;129(5):1246–52.\nMaimon N, Salz L, Shershevsky Y, Matveychuk A, Guber A, Shitrit D. Sarcoidosis-associated pulmonary hypertension in patients with near-normal lung function. Int J Tuberc Lung Dis. 2013;17(3):406–11.\nCorte TJ, Wells AU, Nicholson AG, Hansell DM, Wort SJ. Pulmonary hypertension in sarcoidosis: a review. Respirology. 2011;16(1):69–77.\nParikh KS, Dahhan T, Nicholl L, et al. Clinical features and outcomes of patients with sarcoidosis-associated pulmonary hypertension. Sci Rep. 2019;9(1):4061.\nDuong H, Bonham CA. Sarcoidosis-associated pulmonary hypertension: pathophysiology, diagnosis, and treatment. Clin Pulm Med. 2018;25(2):52–60.\nKirkil G, Lower EE, Baughman RP. Predictors of mortality in pulmonary sarcoidosis. Chest. 2018;153(1):105–13.\nTiosano S, Versini M, Dar Antaki L, et al. The long-term prognostic significance of sarcoidosis-associated pulmonary hypertension – a cohort study. Clin Immunol. 2019;199:57–61.\nBaydur A. Recent developments in the physiological assessment of sarcoidosis: clinical implications. Curr Opin Pulm Med. 2012;18(5):499–505.\nJudson MA, Mack M, Beaumont JL, Watt R, Barnathan ES, Victorson DE. Validation and important differences for the Sarcoidosis Assessment Tool. A new patient-reported outcome measure. Am J Respir Crit Care Med. 2015;191(7):786–95.\nCox CE, Donohue JF, Brown CD, Kataria YP, Judson MA. The Sarcoidosis Health Questionnaire: a new measure of health-related quality of life. Am J Respir Crit Care Med. 2003;168(3):323–9.\nBaughman RP, Lower EE, Saketkoo LA. Clinical trials in pulmonary sarcoidosis. Curr Opin Pulm Med. 2015;21(5):525–31.\nBaughman RP, Judson MA, Beaumont JL, et al. Evaluating the minimal clinically important difference of the King’s Sarcoidosis Questionnaire (KSQ) in a multi-center, prospective study. Ann Am Thorac Soc. 2021;18(3):477–85.\nLo KH, Donohue J, Judson MA, et al. The St. George’s Respiratory Questionnaire in pulmonary sarcoidosis. Lung. 2020;198(6):917–24.\nMcCollister D, Shaffer S, Badesch DB, et al. Development of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT®) questionnaire: a new patient-reported outcome instrument for PAH. Respir Res. 2016;17(1):72.\nChin KM, Gomberg-Maitland M, Channick RN, et al. Psychometric validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) questionnaire: results of the SYMPHONY trial. Chest. 2018;154(4):848–61.\nGuillevin L, Armstrong I, Aldrighetti R, et al. Understanding the impact of pulmonary arterial hypertension on patients’ and carers’ lives. Eur Respir Rev. 2013;22(130):535–42.\nGalie N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J. 2009;30(20):2493–537.\nHsieh HF, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277–88.\nLasch KE, Marquis P, Vigneux M, et al. PRO development: rigorous qualitative research as the crucial foundation. Qual Life Res. 2010;19(8):1087–96.\nFriese S, Ringmayr TG. ATLAS.ti 7 user guide and reference. 2013. https:\u002F\u002Fatlasti.com\u002Fwp-content\u002Fuploads\u002F2014\u002F05\u002Fatlasti_v7_manual_201312.pdf?q=\u002Fuploads\u002Fmedia\u002Fatlasti_v7_manual_201312.pdf. Accessed 7 Sept 2020.\nLeidy NK, Vernon M. Perspectives on patient-reported outcomes: content validity and qualitative research in a changing clinical trial environment. Pharmacoeconomics. 2008;26(5):363–70.\nVictorson DE, Choi S, Judson MA, Cella D. Development and testing of item response theory-based item banks and short forms for eye, skin and lung problems in sarcoidosis. Qual Life Res. 2014;23(4):1301–13.\nPatel AS, Siegert RJ, Creamer D, et al. The development and validation of the King’s Sarcoidosis Questionnaire for the assessment of health status. Thorax. 2013;68(1):57–65.\nBaughman RP, Culver DA, Cordova FC, et al. Bosentan for sarcoidosis-associated pulmonary hypertension: a double-blind placebo controlled randomized trial. Chest. 2014;145(4):810–7.\nBourbonnais JM, Samavati L. Effect of gender on health related quality of life in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2010;27(2):96–102.\nDudvarski-Ilić A, Mihailović-Vucinić V, Gvozdenović B, Zugić V, Milenković B, Ilić V. Health related quality of life regarding to gender in sarcoidosis. Coll Antropol. 2009;33(3):837–40.",{"VOID":935},"10.1186\u002Fs12890-021-01694-1","2024-05-13T11:26:13.095+00:00","https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-021-01694-1",[939,954,969,982,997,1010],{"id":940,"sortIndex":19,"researcher":18,"roles":941,"affiliations":942,"properties":951,"displayName":953,"givenName":18,"familyName":18},"2224aea0-0c81-4fe4-a19c-3a6286c07b54",[187],[943],{"id":944,"sortIndex":19,"affiliation":945,"properties":18},"a75c0671-e716-44d3-83ae-156f0d241f19",{"id":944,"createTime":18,"updateTime":18,"relativeEntities":946,"slug":18,"properties":947,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":950,"statistic":18},[],{"title":948},{"VI":949},"Evidera Inc., Bethesda, USA",[],{"title":952},{"VI":953},"Brooke M. Currie",{"id":955,"sortIndex":137,"researcher":18,"roles":956,"affiliations":957,"properties":966,"displayName":968,"givenName":18,"familyName":18},"82815fdd-1d35-4ccc-8548-ebcaebab78cf",[187],[958],{"id":959,"sortIndex":19,"affiliation":960,"properties":18},"b212d29f-cea4-4a2a-a076-11880a95ca4b",{"id":959,"createTime":18,"updateTime":18,"relativeEntities":961,"slug":18,"properties":962,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":965,"statistic":18},[],{"title":963},{"VI":964},"Actelion Pharmaceuticals Ltd, Allschwil, Basel, Switzerland",[],{"title":967},{"VI":968},"Evan W. Davies",{"id":970,"sortIndex":217,"researcher":18,"roles":971,"affiliations":972,"properties":979,"displayName":981,"givenName":18,"familyName":18},"c098bf73-ad85-488c-9cb4-a302c2bcc874",[187],[973],{"id":959,"sortIndex":19,"affiliation":974,"properties":18},{"id":959,"createTime":18,"updateTime":18,"relativeEntities":975,"slug":18,"properties":976,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":978,"statistic":18},[],{"title":977},{"VI":964},[],{"title":980},{"VI":981},"Amélie Beaudet",{"id":983,"sortIndex":96,"researcher":18,"roles":984,"affiliations":985,"properties":994,"displayName":996,"givenName":18,"familyName":18},"c4a2d65b-107d-423f-9863-ee89053a93a3",[187],[986],{"id":987,"sortIndex":19,"affiliation":988,"properties":18},"e2a342c4-194f-45a8-8480-7022aa10790c",{"id":987,"createTime":18,"updateTime":18,"relativeEntities":989,"slug":18,"properties":990,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":993,"statistic":18},[],{"title":991},{"VI":992},"Evidera, Inc, Seattle, USA",[],{"title":995},{"VI":996},"Larissa Stassek",{"id":998,"sortIndex":95,"researcher":18,"roles":999,"affiliations":1000,"properties":1007,"displayName":1009,"givenName":18,"familyName":18},"151b7fc7-5eb7-446c-85ec-928f36dc677a",[187],[1001],{"id":987,"sortIndex":19,"affiliation":1002,"properties":18},{"id":987,"createTime":18,"updateTime":18,"relativeEntities":1003,"slug":18,"properties":1004,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1006,"statistic":18},[],{"title":1005},{"VI":992},[],{"title":1008},{"VI":1009},"Leah Kleinman",{"id":1011,"sortIndex":400,"researcher":18,"roles":1012,"affiliations":1013,"properties":1022,"displayName":1024,"givenName":18,"familyName":18},"215f01fd-97f8-4736-8765-d5f16bc6bf33",[187],[1014],{"id":1015,"sortIndex":19,"affiliation":1016,"properties":18},"25d1006c-24f0-45cb-8bce-85480b8e18b5",{"id":1015,"createTime":18,"updateTime":18,"relativeEntities":1017,"slug":18,"properties":1018,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1021,"statistic":18},[],{"title":1019},{"VI":1020},"University of Cincinnati Medical Center, Cincinnati, USA",[],{"title":1023},{"VI":1024},"Robert P. Baughman",{"url":937,"publisher":1026,"properties":1067},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1027,"slug":10,"properties":1028,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1031,"manageAffiliations":1036,"indexDatabases":1047,"url":18,"thumbnailPath":18,"statistic":1062,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1029,"eissn":1030},{"EN":13},{"VOID":15},[1032],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1033,"label":1034,"description":1035,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[1037,1042],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":1038,"slug":18,"properties":1039,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1041,"statistic":18},[],{"title":1040},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":1043,"slug":18,"properties":1044,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1046,"statistic":18},[],{"title":1045},{"EN":40},[],[1048,1055],{"id":61,"indexDatabase":1049,"url":72,"indexYears":73,"academicFieldIds":1054,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":1050,"label":1051,"description":1052,"key":69,"publicationTags":1053,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":1056,"url":57,"indexYears":18,"academicFieldIds":1061,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":1057,"label":1058,"description":1059,"key":53,"publicationTags":1060,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":1063,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":1064,"totalCitation":116,"totalCitationByYear":1065,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":1066,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":1068,"volume":1070},{"VOID":1069},"1-10",{"VOID":1071},"21",{"total":19,"publishYear":1073,"statisticByYear":1074},2021,{},"2021-11-12","2026-07-29T23:38:44.309+00:00",[55,76],{"id":1079,"createTime":1080,"updateTime":1081,"relativeEntities":1082,"slug":1083,"properties":1084,"entityType":176,"verifyStatus":177,"verifyTime":1093,"verifyNote":179,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1094,"fullTextUrl":18,"authors":1095,"publicationType":259,"publisherRelationship":1188,"citationCount":1234,"citationInfo":1235,"publishDate":1239,"publishYear":1236,"citationAnalyzeStatus":916,"lastCitationAnalyze":1081,"indexDatabases":1240,"openAccess":18,"references":1241,"isForceReanalyzing":310},"3523b6ae-cb03-4c23-8035-7c6127d45e15","2023-11-24T09:43:05.819+00:00","2026-07-29T02:09:07.390+00:00",[],"Prevalence-of-thoracic-pain-in-patients-with-chronic-obstructive-pulmonary-disease-and-relationship-with-patient-characteristics-a-cross-sectional-observational-study",{"abstract":1085,"title":1087,"gsPaper":1089,"doi":1091},{"EN":1086},"Objectives of this study were to evaluate the prevalence of thoracic pain in patients with chronic obstructive pulmonary disease (COPD) and its relationship with Forced Expiratory Volume in the first second (FEV1), static hyperinflation, dyspnoea, functional exercise capacity, disease-specific health status, anxiety, and depression. This cross-sectional observational study included patients with COPD entering pulmonary rehabilitation. Participants underwent spirometry, plethysmography, and measurement of single breath diffusion capacity. Pain was assessed using a multidimensional, structured pain interview. In addition, dyspnoea severity (Modified Medical Research Council Dyspnoea Scale (mMRC)), functional exercise capacity (six-minute walking distance (6MWD)), disease-specific health status (COPD Assessment Test (CAT)), and symptoms of anxiety and depression (Hospital Anxiety Depression Scale (HADS)) were recorded. 55 of the included 67 participants reported chronic pain (82.1 %). 53.7 % had thoracic pain. After considering multiple comparisons, only younger age and worse CAT scores were related with the presence of thoracic pain (p = 0.01). There were no relationships between thoracic pain and FEV1, static lung hyperinflation, diffusion capacity, mMRC score, 6MWD, anxiety or depression. Thoracic pain is highly prevalent in COPD patients and is related to impaired disease-specific health status, but there is no relationship with FEV1, static hyperinflation, dyspnoea severity or functional exercise capacity.",{"EN":1088},"Prevalence of thoracic pain in patients with chronic obstructive pulmonary disease and relationship with patient characteristics: a cross-sectional observational study",{"VOID":1090},"[\"17200955178797185072\"]",{"VOID":1092},"10.1186\u002Fs12890-016-0210-8","2024-05-02T12:56:48.289+00:00","http:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-016-0210-8",[1096,1120,1142,1155,1168],{"id":1097,"sortIndex":19,"researcher":18,"roles":1098,"affiliations":1099,"properties":1117,"displayName":1119,"givenName":18,"familyName":18},"93c85b17-14cc-4cf8-9a91-3d87df3bb30f",[187],[1100,1108],{"id":1101,"sortIndex":19,"affiliation":1102,"properties":18},"5ea22571-13d9-4bc4-82c9-463eccd31867",{"id":1101,"createTime":18,"updateTime":18,"relativeEntities":1103,"slug":18,"properties":1104,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1107,"statistic":18},[],{"title":1105},{"VI":1106},"Department of Research & Education, CIRO+, centre of expertise for chronic organ failure, Horn, The Netherlands",[],{"id":1109,"sortIndex":137,"affiliation":1110,"properties":1116},"90f7b002-4efa-47f2-ab3d-5d656cbfb76b",{"id":1109,"createTime":18,"updateTime":18,"relativeEntities":1111,"slug":18,"properties":1112,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1115,"statistic":18},[],{"title":1113},{"VI":1114},"Centre of Expertise for Palliative Care, Maastricht University Medical Centre+ (MUMC+), Maastricht, the Netherlands",[],{},{"title":1118},{"VI":1119},"D. J. A. Janssen",{"id":1121,"sortIndex":137,"researcher":18,"roles":1122,"affiliations":1123,"properties":1139,"displayName":1141,"givenName":18,"familyName":18},"280339bc-60a4-4208-b8a5-3405e011ea08",[187],[1124,1130],{"id":1101,"sortIndex":19,"affiliation":1125,"properties":18},{"id":1101,"createTime":18,"updateTime":18,"relativeEntities":1126,"slug":18,"properties":1127,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1129,"statistic":18},[],{"title":1128},{"VI":1106},[],{"id":1131,"sortIndex":137,"affiliation":1132,"properties":1138},"155a5019-1946-45b8-ab48-bc59c2dc1e2c",{"id":1131,"createTime":18,"updateTime":18,"relativeEntities":1133,"slug":18,"properties":1134,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1137,"statistic":18},[],{"title":1135},{"VI":1136},"Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands",[],{},{"title":1140},{"VI":1141},"E. F. M. Wouters",{"id":1143,"sortIndex":217,"researcher":18,"roles":1144,"affiliations":1145,"properties":1152,"displayName":1154,"givenName":18,"familyName":18},"ef5d1966-8b77-4bdf-8a09-acc67f1affa7",[187],[1146],{"id":1101,"sortIndex":19,"affiliation":1147,"properties":18},{"id":1101,"createTime":18,"updateTime":18,"relativeEntities":1148,"slug":18,"properties":1149,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1151,"statistic":18},[],{"title":1150},{"VI":1106},[],{"title":1153},{"VI":1154},"Y. Lozano Parra",{"id":1156,"sortIndex":96,"researcher":18,"roles":1157,"affiliations":1158,"properties":1165,"displayName":1167,"givenName":18,"familyName":18},"1b424c36-3bc9-4986-922f-a623d1711518",[187],[1159],{"id":1101,"sortIndex":19,"affiliation":1160,"properties":18},{"id":1101,"createTime":18,"updateTime":18,"relativeEntities":1161,"slug":18,"properties":1162,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1164,"statistic":18},[],{"title":1163},{"VI":1106},[],{"title":1166},{"VI":1167},"K. Stakenborg",{"id":1169,"sortIndex":95,"researcher":18,"roles":1170,"affiliations":1171,"properties":1185,"displayName":1187,"givenName":18,"familyName":18},"5ad75b70-9f7b-497b-89ce-ec4fcd2f7e70",[187],[1172,1178],{"id":1101,"sortIndex":19,"affiliation":1173,"properties":18},{"id":1101,"createTime":18,"updateTime":18,"relativeEntities":1174,"slug":18,"properties":1175,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1177,"statistic":18},[],{"title":1176},{"VI":1106},[],{"id":1109,"sortIndex":137,"affiliation":1179,"properties":1184},{"id":1109,"createTime":18,"updateTime":18,"relativeEntities":1180,"slug":18,"properties":1181,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1183,"statistic":18},[],{"title":1182},{"VI":1114},[],{},{"title":1186},{"VI":1187},"F. M. E. Franssen",{"url":1094,"publisher":1189,"properties":1230},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1190,"slug":10,"properties":1191,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1194,"manageAffiliations":1199,"indexDatabases":1210,"url":18,"thumbnailPath":18,"statistic":1225,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1192,"eissn":1193},{"EN":13},{"VOID":15},[1195],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1196,"label":1197,"description":1198,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[1200,1205],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":1201,"slug":18,"properties":1202,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1204,"statistic":18},[],{"title":1203},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":1206,"slug":18,"properties":1207,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1209,"statistic":18},[],{"title":1208},{"EN":40},[],[1211,1218],{"id":61,"indexDatabase":1212,"url":72,"indexYears":73,"academicFieldIds":1217,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":1213,"label":1214,"description":1215,"key":69,"publicationTags":1216,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":1219,"url":57,"indexYears":18,"academicFieldIds":1224,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":1220,"label":1221,"description":1222,"key":53,"publicationTags":1223,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":1226,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":1227,"totalCitation":116,"totalCitationByYear":1228,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":1229,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":1231,"volume":1232},{"VOID":304},{"VOID":1233},"16",50,{"total":1234,"publishYear":1236,"statisticByYear":1237},2016,{"2016":137,"2017":853,"2018":99,"2019":853,"2020":1238,"2021":400,"2022":96,"2023":137,"2024":217,"2025":217,"2026":137},9,"2016-04-06",[55,76],[1242,1248,1251,1254,1260,1263,1266,1269,1272,1275,1278,1281,1284,1287,1290,1293,1296,1299,1302,1305,1308,1311,1314,1320,1326,1332,1335,1341,1344,1347,1350,1353,1359,1362,1365,1368,1371],{"id":1243,"text":1244,"url":1245,"identifiers":1246},"4c68646b-0035-4279-8000-0006b275d4fa","Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187(4):347–65.","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":1247},"10.1007\u002Fs10440-022-00541-7",{"id":1243,"text":1249,"url":1245,"identifiers":1250},"Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–128.",{"doi":1247},{"id":1243,"text":1252,"url":1245,"identifiers":1253},"Viegi G, Pistelli F, Sherrill DL, Maio S, Baldacci S, Carrozzi L. Definition, epidemiology and natural history of COPD. Eur Respir J. 2007;30(5):993–1013.",{"doi":1247},{"id":1255,"text":1256,"url":1257,"identifiers":1258},"c35ab2b4-fd57-43e4-b69a-a1e66802954d","Carrasco Garrido P, de Miguel DJ, Rejas Gutierrez J, Centeno AM, Gobartt Vazquez E, Gil De Miguel A, Garcia Carballo M, Jimenez Garcia R. Negative impact of chronic obstructive pulmonary disease on the health-related quality of life of patients Results of the EPIDEPOC study. Health Qual Life Outcomes. 2006;4:31.","https:\u002F\u002Fhqlo.biomedcentral.com\u002Farticles\u002F10.1186\u002F1477-7525-4-31",{"doi":1259},"10.1186\u002F1477-7525-4-31",{"id":1243,"text":1261,"url":1245,"identifiers":1262},"Janssen DJ, Spruit MA, Uszko-Lencer NH, Schols JM, Wouters EF. Symptoms, comorbidities, and health care in advanced chronic obstructive pulmonary disease or chronic heart failure. J Palliat Med. 2011;14(6):735–43.",{"doi":1247},{"id":1243,"text":1264,"url":1245,"identifiers":1265},"Merskey H, Bogduk N. Classification of chronic pain. Descriptions of chronic pain syndromes and definitions of pain terms. Prepared by the International Association for the Study of Pain, Subcommittee on Taxonomy. Pain Supplement 1986, 3:S1-226.",{"doi":1247},{"id":1243,"text":1267,"url":1245,"identifiers":1268},"van Dam van Isselt EF, Groenewegen-Sipkema KH, Spruit-van Eijk M, Chavannes NH, de Waal MW, Janssen DJ, Achterberg WP. Pain in patients with COPD: a systematic review and meta-analysis. BMJ Open. 2014;4(9):e005898.",{"doi":1247},{"id":18,"text":1270,"url":18,"identifiers":1271},"Lee AL, Harrison SL, Goldstein RS, Brooks D. Pain and its clinical associations in individuals with COPD: a systematic review. Chest. 2015;147(5):1246–58.",{},{"id":1243,"text":1273,"url":1245,"identifiers":1274},"Roberts MH, Mapel DW, Hartry A, Von Worley A, Thomson H. Chronic pain and pain medication use in chronic obstructive pulmonary disease. A cross-sectional study. Ann Am Thorac Soc. 2013;10(4):290–8.",{"doi":1247},{"id":1243,"text":1276,"url":1245,"identifiers":1277},"Bentsen SB, Rustoen T, Miaskowski C. Prevalence and characteristics of pain in patients with chronic obstructive pulmonary disease compared to the Norwegian general population. J Pain. 2011;12(5):539–45.",{"doi":1247},{"id":1243,"text":1279,"url":1245,"identifiers":1280},"Janssen DJ, Franssen FM, Wouters EF, Schols JM, Spruit MA. Impaired health status and care dependency in patients with advanced COPD or chronic heart failure. Qual Life Res. 2011;20(10):1679–88.",{"doi":1247},{"id":1243,"text":1282,"url":1245,"identifiers":1283},"O’Donnell DE, Laveneziana P. The clinical importance of dynamic lung hyperinflation in COPD. COPD. 2006;3(4):219–32.",{"doi":1247},{"id":18,"text":1285,"url":18,"identifiers":1286},"Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, Hill K, Holland AE, Lareau SC, Man WD, et al. An official American Thoracic Society\u002FEuropean Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188(8):e13–64.",{},{"id":1243,"text":1288,"url":1245,"identifiers":1289},"Charlson ME, Pompei P, Ales KL, and MacKenzie CR. A new method ofclassifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83.",{"doi":1247},{"id":1243,"text":1291,"url":1245,"identifiers":1292},"Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax. 1999;54(7):581–6.",{"doi":1247},{"id":18,"text":1294,"url":18,"identifiers":1295},"Hegewald MJ. Diffusing capacity. Clin Rev Allergy Immunol. 2009;37(3):159–66.",{},{"id":18,"text":1297,"url":18,"identifiers":1298},"A.T.S. Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002, 166(1):111–117.",{},{"id":1243,"text":1300,"url":1245,"identifiers":1301},"Dodd JW, Hogg L, Nolan J, Jefford H, Grant A, Lord VM, Falzon C, Garrod R, Lee C, Polkey MI, et al. The COPD assessment test (CAT): response to pulmonary rehabilitation. A multicentre, prospective study. Thorax. 2011;66(5):425–9.",{"doi":1247},{"id":18,"text":1303,"url":18,"identifiers":1304},"Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002;52(2):69–77.",{},{"id":18,"text":1306,"url":18,"identifiers":1307},"De Graeff A, Hesselmann GM, Krol RJA, Kuyper MB, Verhagen EH, Volbaard EJ. Palliatieve zorg. Richtlijnen voor de praktijk. Utrecht: VIKC; 2006.",{},{"id":18,"text":1309,"url":18,"identifiers":1310},"Oldenmenger WH, Stronks DL, Terwiel CTM, Verhage S, Gootjes JRG, Klomp M, de Wit R. Naar een landelijke, uniforme verpleegkundige pijnanamnese. Psychometrische kwaliteiten. Nederlands Tijdschift voor Pijn en Pijnbestrijding. 2005;25(25):6–12.",{},{"id":1243,"text":1312,"url":1245,"identifiers":1313},"Keller S, Bann CM, Dodd SL, Schein J, Mendoza TR, Cleeland CS. Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain. Clin J Pain. 2004;20(5):309–18.",{"doi":1247},{"id":1315,"text":1316,"url":1317,"identifiers":1318},"f551b598-4fc7-4355-b28d-a9e32aa1c209","Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain. 1975;1(3):277–99.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0304395975900445",{"doi":1319},"10.1016\u002F0304-3959(75)90044-5",{"id":1321,"text":1322,"url":1323,"identifiers":1324},"8a7a3685-ea60-411d-9617-4f7a6bb7223a","Borge CR, Wahl AK, Moum T. Pain and quality of life with chronic obstructive pulmonary disease. Heart Lung. 2011;40(3):e90–101.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0147956310003730",{"doi":1325},"10.1016\u002Fj.hrtlng.2010.10.009",{"id":1327,"text":1328,"url":1329,"identifiers":1330},"091e30af-702c-40d3-93b5-cbb3ea52d02d","Kon SS, Canavan JL, Jones SE, Nolan CM, Clark AL, Dickson MJ, Haselden BM, Polkey MI, Man WD. Minimum clinically important difference for the COPD Assessment Test: a prospective analysis. Lancet Respir Med. 2014;2(3):195–203.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS2213260014700013",{"doi":1331},"10.1016\u002Fs2213-2600(14)70001-3",{"id":1243,"text":1333,"url":1245,"identifiers":1334},"Jones PW, Harding G, Wiklund I, Berry P, Tabberer M, Yu R, Leidy NK. Tests of the responsiveness of the COPD assessment test following acute exacerbation and pulmonary rehabilitation. Chest. 2012;142(1):134–40.",{"doi":1247},{"id":1336,"text":1337,"url":1338,"identifiers":1339},"e8d43fcc-0787-4769-9a9f-a06d5531b911","Lohne V, Heer HC, Andersen M, Miaskowski C, Kongerud J, Rustoen T. Qualitative study of pain of patients with chronic obstructive pulmonary disease. Heart Lung. 2010;39(3):226–34.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0147956309002040",{"doi":1340},"10.1016\u002Fj.hrtlng.2009.08.002",{"id":1243,"text":1342,"url":1245,"identifiers":1343},"Habraken JM, Pols J, Bindels PJ, Willems DL. The silence of patients with end-stage COPD: a qualitative study. Br J Gen Pract. 2008;58(557):844–9.",{"doi":1247},{"id":1243,"text":1345,"url":1245,"identifiers":1346},"Lopez Varela MV, Montes De Oca M, Halbert RJ, Muino A, Perez-Padilla R, Talamo C, Jardim JR, Valdivia G, Pertuze J, Moreno D, et al. Sex-related differences in COPD in five Latin American cities: the PLATINO study. Eur Respir J. 2010;36(5):1034–41.",{"doi":1247},{"id":1243,"text":1348,"url":1245,"identifiers":1349},"Martinez FJ, Curtis JL, Sciurba F, Mumford J, Giardino ND, Weinmann G, Kazerooni E, Murray S, Criner GJ, Sin DD, et al. Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med. 2007;176(3):243–52.",{"doi":1247},{"id":1243,"text":1351,"url":1245,"identifiers":1352},"Lamprecht B, Vanfleteren LE, Studnicka M, Allison M, McBurnie MA, Vollmer WM, Tan WC, Nielsen R, Nastalek P, Gnatiuc L, et al. Sex-related differences in respiratory symptoms: results from the BOLD Study. Eur Respir J. 2013;42(3):858–60.",{"doi":1247},{"id":1354,"text":1355,"url":1356,"identifiers":1357},"b35fc209-f237-43f4-af07-1cf32910c7c0","Puhan MA, Frey M, Buchi S, Schunemann HJ. The minimal important difference of the hospital anxiety and depression scale in patients with chronic obstructive pulmonary disease. Health Qual Life Outcomes. 2008;6:46.","http:\u002F\u002Fhqlo.biomedcentral.com\u002Farticles\u002F10.1186\u002F1477-7525-6-46",{"doi":1358},"10.1186\u002F1477-7525-6-46",{"id":1243,"text":1360,"url":1245,"identifiers":1361},"Borge CR, Wahl AK, Moum T. Association of breathlessness with multiple symptoms in chronic obstructive pulmonary disease. J Adv Nurs. 2010;66(12):2688–700.",{"doi":1247},{"id":1243,"text":1363,"url":1245,"identifiers":1364},"Bentsen SB, Rustoen T, Miaskowski C. Differences in subjective and objective respiratory parameters in patients with chronic obstructive pulmonary disease with and without pain. Int J Chron Obstruct Pulmon Dis. 2012;7:137–43.",{"doi":1247},{"id":1243,"text":1366,"url":1245,"identifiers":1367},"Meek PM. Measurement of dyspnea in chronic obstructive pulmonary disease: what is the tool telling you? Chron Respir Dis. 2004;1(1):29–37.",{"doi":1247},{"id":1243,"text":1369,"url":1245,"identifiers":1370},"Clark N, Fan VS, Slatore CG, Locke E, Whitson HE, Nici L, Thielke SM. Dyspnea and pain frequently co-occur among Medicare managed care recipients. Ann Am Thoracic Soc. 2014;11(6):890–7.",{"doi":1247},{"id":1243,"text":1372,"url":1245,"identifiers":1373},"Woo A, Lechner B, Fu T, Wong CS, Chiu N, Lam H, Pulenzas N, Soliman H, DeAngelis C, Chow E. Cut points for mild, moderate, and severe pain among cancer and non-cancer patients: a literature review. Ann Palliat Med. 2015;4(4):176–83.",{"doi":1247},{"id":1375,"createTime":1376,"updateTime":1377,"relativeEntities":1378,"slug":1379,"properties":1380,"entityType":176,"verifyStatus":177,"verifyTime":1389,"verifyNote":179,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1390,"fullTextUrl":18,"authors":1391,"publicationType":259,"publisherRelationship":1472,"citationCount":1518,"citationInfo":1519,"publishDate":1522,"publishYear":1520,"citationAnalyzeStatus":916,"lastCitationAnalyze":1377,"indexDatabases":1523,"openAccess":18,"references":1524,"isForceReanalyzing":310},"5351eea4-1592-4448-807e-77833aaa9d09","2023-12-28T08:31:40.488+00:00","2026-07-26T20:48:40.176+00:00",[],"Effect-of-low-tidal-volume-ventilation-on-lung-function-and-inflammation-in-mice",{"abstract":1381,"title":1383,"gsPaper":1385,"doi":1387},{"EN":1382},"A large number of studies have investigated the effects of high tidal volume ventilation in mouse models. In contrast data on very short term effects of low tidal volume ventilation are sparse. Therefore we investigated the functional and structural effects of low tidal volume ventilation in mice. 38 Male C57\u002FBl6 mice were ventilated with different tidal volumes (Vt 5, 7, and 10 ml\u002Fkg) without or with application of PEEP (2 cm H2O). Four spontaneously breathing animals served as controls. Oxygen saturation and pulse rate were monitored. Lung function was measured every 5 min for at least 30 min. Afterwards lungs were removed and histological sections were stained for measurement of infiltration with polymorphonuclear leukocytes (PMN). Moreover, mRNA expression of macrophage inflammatory protein (MIP)-2 and tumor necrosis factor (TNF)α in the lungs was quantified using real time PCR. Oxygen saturation did not change significantly over time of ventilation in all groups (P > 0.05). Pulse rate dropped in all groups without PEEP during mechanical ventilation. In contrast, in the groups with PEEP pulse rate increased over time. These effects were not statistically significant (P > 0.05). Tissue damping (G) and tissue elastance (H) were significantly increased in all groups after 30 min of ventilation (P \u003C 0.05). Only the group with a Vt of 10 ml\u002Fkg and PEEP did not show a significant increase in H (P > 0.05). Mechanical ventilation significantly increased infiltration of the lungs with PMN (P \u003C 0.05). Expression of MIP-2 was significantly induced by mechanical ventilation in all groups (P \u003C 0.05). MIP-2 mRNA expression was lowest in the group with a Vt of 10 ml\u002Fkg + PEEP. Our data show that very short term mechanical ventilation with lower tidal volumes than 10 ml\u002Fkg did not reduce inflammation additionally. Formation of atelectasis and inadequate oxygenation with very low tidal volumes may be important factors. Application of PEEP attenuated inflammation.",{"EN":1384},"Effect of low tidal volume ventilation on lung function and inflammation in mice",{"VOID":1386},"[\"9896454521727112700\"]",{"VOID":1388},"10.1186\u002F1471-2466-10-21","2024-05-03T19:25:40.971+00:00","https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002F1471-2466-10-21",[1392,1416,1429,1446,1459],{"id":1393,"sortIndex":19,"researcher":18,"roles":1394,"affiliations":1395,"properties":1413,"displayName":1415,"givenName":18,"familyName":18},"208761af-e5bf-4705-b4f2-6c21e3ebb423",[187],[1396,1404],{"id":1397,"sortIndex":19,"affiliation":1398,"properties":18},"b5c6eafc-31a6-4344-bfcc-8c41f88d52e0",{"id":1397,"createTime":18,"updateTime":18,"relativeEntities":1399,"slug":18,"properties":1400,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1403,"statistic":18},[],{"title":1401},{"VI":1402},"Division of Pathophysiology of Inflammation, Research Center Borstel, Borstel, Germany",[],{"id":1405,"sortIndex":137,"affiliation":1406,"properties":1412},"c88e418e-6d34-4a38-8aff-1b1057dcc647",{"id":1405,"createTime":18,"updateTime":18,"relativeEntities":1407,"slug":18,"properties":1408,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1411,"statistic":18},[],{"title":1409},{"VI":1410},"Medical Clinic, Research Center Borstel, Borstel, Germany",[],{},{"title":1414},{"VI":1415},"Hans P Hauber",{"id":1417,"sortIndex":137,"researcher":18,"roles":1418,"affiliations":1419,"properties":1426,"displayName":1428,"givenName":18,"familyName":18},"149bc6e4-0665-4f2b-ae61-3d10d5fe78f2",[187],[1420],{"id":1397,"sortIndex":19,"affiliation":1421,"properties":18},{"id":1397,"createTime":18,"updateTime":18,"relativeEntities":1422,"slug":18,"properties":1423,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1425,"statistic":18},[],{"title":1424},{"VI":1402},[],{"title":1427},{"VI":1428},"Dörte Karp",{"id":1430,"sortIndex":217,"researcher":18,"roles":1431,"affiliations":1432,"properties":1441,"displayName":1443,"givenName":18,"familyName":18},"17687fbe-a8bb-4bfd-83b8-1d286e4c4cb6",[187],[1433],{"id":1434,"sortIndex":19,"affiliation":1435,"properties":18},"e2482c21-043f-4ff1-ab73-88162a6a9c34",{"id":1434,"createTime":18,"updateTime":18,"relativeEntities":1436,"slug":18,"properties":1437,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1440,"statistic":18},[],{"title":1438},{"VI":1439},"Division of Experimental Pathology, Research Center Borstel, Borstel, Germany",[],{"title":1442,"gsAuthor":1444},{"VI":1443},"Torsten Goldmann",{"VOID":1445},"[\"TWh4or0AAAAJ\"]",{"id":1447,"sortIndex":96,"researcher":18,"roles":1448,"affiliations":1449,"properties":1456,"displayName":1458,"givenName":18,"familyName":18},"626f961c-65d6-4dee-8984-c4013deecc8e",[187],[1450],{"id":1434,"sortIndex":19,"affiliation":1451,"properties":18},{"id":1434,"createTime":18,"updateTime":18,"relativeEntities":1452,"slug":18,"properties":1453,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1455,"statistic":18},[],{"title":1454},{"VI":1439},[],{"title":1457},{"VI":1458},"Ekkehard Vollmer",{"id":1460,"sortIndex":95,"researcher":18,"roles":1461,"affiliations":1462,"properties":1469,"displayName":1471,"givenName":18,"familyName":18},"e518ca57-e08f-4e8b-844b-cfa49ab95787",[187],[1463],{"id":1405,"sortIndex":19,"affiliation":1464,"properties":18},{"id":1405,"createTime":18,"updateTime":18,"relativeEntities":1465,"slug":18,"properties":1466,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1468,"statistic":18},[],{"title":1467},{"VI":1410},[],{"title":1470},{"VI":1471},"Peter Zabel",{"url":1390,"publisher":1473,"properties":1514},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1474,"slug":10,"properties":1475,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1478,"manageAffiliations":1483,"indexDatabases":1494,"url":18,"thumbnailPath":18,"statistic":1509,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1476,"eissn":1477},{"EN":13},{"VOID":15},[1479],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1480,"label":1481,"description":1482,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[1484,1489],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":1485,"slug":18,"properties":1486,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1488,"statistic":18},[],{"title":1487},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":1490,"slug":18,"properties":1491,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1493,"statistic":18},[],{"title":1492},{"EN":40},[],[1495,1502],{"id":61,"indexDatabase":1496,"url":72,"indexYears":73,"academicFieldIds":1501,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":1497,"label":1498,"description":1499,"key":69,"publicationTags":1500,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":1503,"url":57,"indexYears":18,"academicFieldIds":1508,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":1504,"label":1505,"description":1506,"key":53,"publicationTags":1507,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":1510,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":1511,"totalCitation":116,"totalCitationByYear":1512,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":1513,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":1515,"volume":1516},{"VOID":304},{"VOID":1517},"10",35,{"total":1518,"publishYear":1520,"statisticByYear":1521},2010,{"2011":95,"2012":1238,"2013":137,"2014":217,"2015":400,"2016":137,"2018":217,"2020":137,"2022":95,"2023":95,"2024":217},"2010-04-21",[55,76],[1525,1528,1532,1538,1544,1547,1550,1553,1556,1564,1567,1570,1573,1576,1579,1587,1590,1593,1596,1605,1613,1616,1621,1624,1627,1635,1643,1647,1653],{"id":1243,"text":1526,"url":1245,"identifiers":1527},"Webb HH, Tierney DF: Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures: protection by positive end-expiratory pressure. Am Rev Respir Dis. 1974, 110: 556-565.",{"doi":1247},{"id":18,"text":1529,"url":18,"identifiers":1530},"The Acute Respiratory Distress Network: Ventilation with lower tidal volumes as compared with traditional volumes for acute lung injury in the acute respiratory distress syndrome. N Engl J Med. 2000, 342: 1301-1308. 10.1056\u002FNEJM200005043421801.",{"doi":1531},"10.1056\u002FNEJM200005043421801",{"id":1533,"text":1534,"url":1535,"identifiers":1536},"7f261d22-fb95-497e-a7e3-77610977ec2b","Tremblay LN, Slutsky AS: entilator-induced lung injury: from bench to bedside. Intensive Care Med. 2006, 32: 24-33. 10.1007\u002Fs00134-005-2817-8.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00134-005-2817-8",{"doi":1537},"10.1007\u002Fs00134-005-2817-8",{"id":1539,"text":1540,"url":1541,"identifiers":1542},"8101cced-c853-42f9-a557-6e3fe0a69a67","Frank JA, Matthay MA: Science review: mechanisms of ventilator-induced lung injury. Crit Care. 2003, 7: 233-241. 10.1186\u002Fcc1829.","https:\u002F\u002Fccforum.biomedcentral.com\u002Farticles\u002F10.1186\u002Fcc1829",{"doi":1543},"10.1186\u002Fcc1829",{"id":1243,"text":1545,"url":1245,"identifiers":1546},"Al-Jamal R, Ludwig MS: Changes in proteoglycans and lung tissue mechanics during excessive mechanical ventilation in rats. Am J Physiol Lung Cell Mol Physiol. 2001, 281: L1078-L1087.",{"doi":1247},{"id":1243,"text":1548,"url":1245,"identifiers":1549},"Corbridge TC, Wood LD, Crawford GP, Chudoba MJ, Yanos J, Sznajder JI: Adverse effects of large tidal volume and low PEEP in canine acid aspiration. Am Rev Respir Dis. 1990, 142: 311-315.",{"doi":1247},{"id":1243,"text":1551,"url":1245,"identifiers":1552},"Dreyfuss D, Basset G, Soler P, Saumon G: Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary mircovascular injury in rats. Am Rev Respir Dis. 1985, 132: 880-884.",{"doi":1247},{"id":1243,"text":1554,"url":1245,"identifiers":1555},"Uhlig S: Ventilation-induced lung injury and mechanotransduction: stretching it too far?. Am J Physiol Lung Cell Mol Physiol. 2002, 282: L892-L896.",{"doi":1247},{"id":18,"text":1557,"url":1558,"identifiers":1559},"Veldhuizen RA, Slutsky AS, Joseph M, McCraig L: Effects of mechanical ventilation of isolated mouse lungs on surfactant and inflammatory cytokines. Eur Respir J. 2001, 17: 488-494. 10.1183\u002F09031936.01.17304880.","https:\u002F\u002Fdoi.org\u002F10.1183\u002F09031936.01.17304880",{"mag":1560,"openalex":1561,"pm":1562,"doi":1563},"2007547216","W2007547216","11405530","10.1183\u002F09031936.01.17304880",{"id":18,"text":1565,"url":18,"identifiers":1566},"Richard JC, Maggiore SM, Jonson B, Mancebo J, Lemaire F, Brochard L: Influence of tidal volume on alveolar recruitment. Respective role of PEEP and a recruitment maneuver. Am J Respir Crit Care Med. 2001, 163: 1609-1613.",{},{"id":1243,"text":1568,"url":1245,"identifiers":1569},"Allen G, Lundblad LK, Parsons P, Bates JH: Transient mechanical benefits of a deep inflation in the injured mouse lung. J Appl Physiol. 2002, 93: 1709-1715.",{"doi":1247},{"id":1243,"text":1571,"url":1245,"identifiers":1572},"Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC: Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. J Immunol. 2005, 175: 3369-3376.",{"doi":1247},{"id":1243,"text":1574,"url":1245,"identifiers":1575},"Chuimello D, Pristine G, Slutsky : Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med. 1999, 160: 109-116.",{"doi":1247},{"id":1243,"text":1577,"url":1245,"identifiers":1578},"Wilson MR, Choudhury S, Goddard ME, O'Dea KP, Nicholson AG, Takata M: High tidal volume upregulates intrapulmonary cytokines in an in vivo model of ventilator-induced lung injury. J Appl Physiol. 2003, 95: 1385-1393.",{"doi":1247},{"id":18,"text":1580,"url":1581,"identifiers":1582},"Wilson MR, Choudhury S, Takata M: Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signalling in mice. Am J Physiol Lung Cell Mol Physiol. 2005, 288: L599-L607. 10.1152\u002Fajplung.00304.2004.","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajplung.00304.2004",{"mag":1583,"openalex":1584,"pm":1585,"doi":1586},"1988953824","W1988953824","15489373","10.1152\u002Fajplung.00304.2004",{"id":1243,"text":1588,"url":1245,"identifiers":1589},"Tankersley CG, Fitzgerald RS, Kleeberger SR: Differential control of ventilation among inbred strains of mice. Am J Physiol Regul Integr Comp Physiol. 1994, 267: R1371-R1377.",{"doi":1247},{"id":1243,"text":1591,"url":1245,"identifiers":1592},"Tankersley CG, Fitzgerald RS, Levitt RC, Mitzner WA, Ewart SL, Kleeberger SR: Genetic control of differential baseline breathing pattern. J Appl Physiol. 1997, 82: 874-881.",{"doi":1247},{"id":1243,"text":1594,"url":1245,"identifiers":1595},"Bates JH: Understanding lung tissue mechanics in terms of mathematical models. Monaldi Arch Chest Dis. 1993, 73: 134-139.",{"doi":1247},{"id":18,"text":1597,"url":1598,"identifiers":1599},"Massa CB, Allen GB, Bates JHT: Modeling the dynamics of recruitment and derecruitment in mice with acute lung injury. J Appl Physiol. 2008, 105: 1813-1821. 10.1152\u002Fjapplphysiol.90806.2008.","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fjapplphysiol.90806.2008",{"mag":1600,"pmc":1601,"openalex":1602,"pm":1603,"doi":1604},"2025792788","2612465","W2025792788","18948446","10.1152\u002Fjapplphysiol.90806.2008",{"id":18,"text":1606,"url":1607,"identifiers":1608},"Cannizzaro V, Berry LJ, Nicholls PPK, Zosky GR, Turner DJ, Hantos Z, Sly PD: Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice. Respir Physiol Neurobiol. 2009, 169: 243-251. 10.1016\u002Fj.resp.2009.09.012.","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.resp.2009.09.012",{"mag":1609,"openalex":1610,"pm":1611,"doi":1612},"2045835471","W2045835471","19788941","10.1016\u002Fj.resp.2009.09.012",{"id":1243,"text":1614,"url":1245,"identifiers":1615},"Wilson MR, Choudhury S, Goddard ME, O'Dea KP, Nicholson AG, Takata M: High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J Appl Physiol. 2003, 95: 1385-1393.",{"doi":1247},{"id":18,"text":1617,"url":1618,"identifiers":1619},"Imanaka H, Shimaoka M, Matsuura N, Nishimura M, Ohta N, Kiyono H: Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs. Anesthesia Analgesia. 2001, 92: 428-436. 10.1097\u002F00000539-200102000-00029.","http:\u002F\u002Fdx.doi.org\u002F10.1213\u002F00000539-200102000-00029",{"doi":1620},"10.1213\u002F00000539-200102000-00029",{"id":1243,"text":1622,"url":1245,"identifiers":1623},"Dreyfuss D, Soler P, Basset G, Saumon G: High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis. 1988, 137: 1159-1164.",{"doi":1247},{"id":1243,"text":1625,"url":1245,"identifiers":1626},"Sugiura M, McCulloch PR, Wren S, Dawson RH, Froese AB: Ventilator pattern incluences neutrophil influx and activation in atelectasis-prone rabbit lung. J Appl Physiol. 1994, 77: 1355-1365.",{"doi":1247},{"id":18,"text":1628,"url":1629,"identifiers":1630},"Choudhury S, Wilson MR, Goddard ME, O'Dea KP, Takata M: Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2004, 287: L902-L910. 10.1152\u002Fajplung.00187.2004.","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajplung.00187.2004",{"mag":1631,"openalex":1632,"pm":1633,"doi":1634},"2052533687","W2052533687","15257987","10.1152\u002Fajplung.00187.2004",{"id":18,"text":1636,"url":1637,"identifiers":1638},"Caruso P, Meireles SI, Reis LF, Mauad T, Martins MA, Deheinzellin D: Low tidal volume ventilation induces proinflammatory and profibrogenic response in lungs of rats. Intensive Care Med. 2003, 29: 1808-1811. 10.1007\u002Fs00134-003-1908-7.","https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00134-003-1908-7",{"mag":1639,"openalex":1640,"pm":1641,"doi":1642},"2044781231","W2044781231","12904859","10.1007\u002Fs00134-003-1908-7",{"id":18,"text":1644,"url":18,"identifiers":1645},"Terragni PP, Del Sorbo L, Mascia L, Urbino R, Martin EL, Birocco A, Faggiano C, Quintel M, Gattinoni L, Ranieri VM: Tidal volume lower than 6 ml\u002Fkg enhances lung protection: role of extracorporeal carbon dioxide removal. Anaesthesiology. 2009, 111: 826-835. 10.1097\u002FALN.0b013e3181b764d2.",{"doi":1646},"10.1097\u002FALN.0b013e3181b764d2",{"id":1648,"text":1649,"url":1650,"identifiers":1651},"c15131ed-18a0-4435-ac88-9f258d6d9e03","Nakos G, Tsangaris H, Liokatis S, Kitsiouli E, Lekka ME: Ventilator-associated pneumonia and atelectasis: evaluation through bronchoalveolar lavage fluid analysis. Intensive Care Med. 2003, 29: 555-563.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00134-003-1680-8",{"doi":1652},"10.1007\u002Fs00134-003-1680-8",{"id":18,"text":1654,"url":1655,"identifiers":1656},"The pre-publication history for this paper can be accessed here:http:\u002F\u002Fwww.biomedcentral.com\u002F1471-2466\u002F10\u002F21\u002Fprepub","http:\u002F\u002Fwww.biomedcentral.com\u002F1471-2466\u002F10\u002F21\u002Fprepub",{},{"id":1658,"createTime":1659,"updateTime":1660,"relativeEntities":1661,"slug":1662,"properties":1663,"entityType":176,"verifyStatus":177,"verifyTime":1674,"verifyNote":179,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1675,"fullTextUrl":18,"authors":1676,"publicationType":259,"publisherRelationship":1895,"citationCount":19,"citationInfo":1940,"publishDate":1942,"publishYear":1073,"citationAnalyzeStatus":916,"lastCitationAnalyze":1943,"indexDatabases":1944,"openAccess":18,"references":18,"isForceReanalyzing":310},"f4c1e089-9fb5-4c5b-810c-8cae3291e547","2024-02-14T07:27:52.498+00:00","2026-07-26T01:34:33.344+00:00",[],"Predictors-of-community-acquired-childhood-pneumonia-among-2-59-months-old-children-in-the-Amhara-Region-Ethiopia",{"abstract":1664,"title":1666,"gsPaper":1668,"references":1670,"doi":1672},{"EN":1665},"Worldwide, pneumonia is the third leading cause of death in under 5 years children. Ethiopia is ranked 4th out of 15 countries having the highest burdens of the death rate among under-five children due to pneumonia. Regardless of this fact, efforts to identify determinants of pneumonia have been limited yet in Amhara region. This study was aimed to identify predictors of community-acquired childhood pneumonia among 2–59 months old children in the Amhara region, Ethiopia. Facility-based case–control study was conducted in the Amhara region from June 4 to July 15, 2018, among 28 health centers distributed across the region. The total sample size used was 888 (296 cases and 592 controls) children whose age were 2–59 months. At first, multistage sampling technique was employed. Data were collected on a face-to-face interview. Epi data v. 4.6 for data entry and statistical packages for social sciences version 23 for data analysis were used. Multivariable logistic regression analyses were used to test the associations between the study variables at P-value \u003C 0.05 with 95% CI. As a result, determinants were identified for CAP. Among 888 enrolled children (296 cases and 592 controls), who experienced a community-acquired pneumonia had an increased risk of maternal age of 18–24 years (AOR 0.03, at 95%CI (0.01, 0.14), Government employee (AOR 0.19, at 95% CI (0.07,0.54), lack of separate kitchen (AOR 5.37; at 95% CI (1.65, 17.43), history of diarrhea in the past two weeks (AOR 10.2; at 95% CI (5.13, 20.18), previous respiratory tract infections (AOR 8.3, at 95% CI (3.32, 20.55) and history of parental asthma (AOR 4.9, at 95% CI (2.42, 10.18). Maternal age of 18–24 years and government employee, lack of separate kitchen, history of diarrhea in the past two weeks; previous respiratory tract infection and history of parental asthma were found statistically significant. Health personnel’s needs to focus on creating awareness to the community on the merit of the separate kitchen for reduction of Community-acquired childhood pneumonia, and focus on prevention and management of childhood diarrheal and acute respiratory tract infections.",{"EN":1667},"Predictors of community acquired childhood pneumonia among 2–59 months old children in the Amhara Region, Ethiopia",{"VOID":1669},"[\"947301071830294391\"]",{"VOID":1671},"Carol M, Glenn PM. Concepts of altered health states. New York: Walters Kluwer Health Lippincott Williams & Wilkins, 676–80.\nWHO. Revised WHO classification and treatment of childhood pneumonia at health facilities. 2014.\nWorld Pneumonia Day 2016. Available from: http:\u002F\u002Fwww.who.int\u002Fmediacentre\u002Ffactsheets\u002Ffs331\u002Fen\u002F\nMarkos Y, Dadi AF, Demisse AG, Habitu YA, Derseh BT, Debalkie G. Determinants of under-five pneumonia at Gondar University Hospital, Northwest Ethiopia. J Environ Public Health. 2019;2019:8.\nGeleta D, Tessema F, Ewnetu H. Determinants of community acquired pneumonia among children in Kersa District, Southwest Ethiopia. J Pediatr Neonatal Care. 2016;5(2):00179.\nChen J, Hu P, Zhou T, Zheng T, Zhou L, Jiang C, et al. Epidemiology and clinical characteristics of acute respiratory tract infections among hospitalized infants and young children in Chengdu, West China. BMC Pediatr. 2018;18(216):1–8.\nGetaneh S, Alem G, Meseret M, Miskir Y, Tewabe T, Molla G, et al. Determinants of pneumonia among 2–59 months old children at Debre Markos referral hospital, Northwest Ethiopia. BMC Pulm Med. 2019;19(147):1–9.\nHassena S, Getachewa M, Eneyewa B, Keleba A, Ademasa A, Berihuna G, et al. Determinants of acute respiratory infection (ARI) among under-five children in rural areas of Legambo District, South Wollo Zone, Ethiopia. Int J Infect Dis. 2020;96:688.\nAbel Fekadu D, Yigzaw K, Zelalem B. Determinants of pneumonia in children aged two months to five years in Urban Areas of Oromia Zone, Amhara Region, Ethiopia. Open Access Li;2014.\nAlemayehu S, Kidanu K, Kahsay T, Kassa M. Risk factors of acute respiratory infections among under five children attending public hospitals in southern Tigray, Ethiopia. BMC Pediatr. 2019;19(380):1–8.\nRazanajatovo NH, Guillebaud J, Harimanana A, Rajatonirina S, Ratsima EH, Andrianirina ZZ, et al. Epidemiology of severe acute respiratory infections from hospital-based surveillance in Madagascar. PLoS ONE. 2018;13:e0205124.\nMangen M-JJ, Huijts SM, Bonten MJM, Wit GAD. The impact of community-acquired pneumonia on the health-related quality of-life in elderly. BMC Infect Dis. 2017;17(208):1–9.\nUNICEF. One is too many: ending child deaths from pneumonia and diarrhea. New York: UNICEF; 2016.\nGeleta D, Tessema F, Ewnetu H. Determinants of community acquired pneumonia among children in Kersa District, Southwest Ethiopia: facility based case control study. J Pediatr Neonatal Care. 2016;5(2):00179.\nFederal Democratic Republic of Ethiopia (FDRE). EDHS 2016 Final report. (Addis Ababa, Ethiopia).\nFekadu GA, Terefe MW, Alemie GA. Prevalence of pneumonia among under- five children in Este Town and the surrounding Rural Kebeles, Northwest Ethiopia: a community based cross sectional study. Sci J Public Health. 2014;2(3):150–5.\nBendel RB, Afifi AA. Comparison of stoping rules in forward “stepwise regression. J Am Stat Assoc. 1977;72:357.\nChildhood illnesses. Fonseca Limaet al BMC Pediatrics [Internet]. 2016;16(15). Available from: www.biomedcentral.com\u002Fsubmit\nUNICEF, Estimates of child cause of death, acute respiratory infection [Internet]. 2015. Available from: https:\u002F\u002Fdata.unicef.org\u002Fchild-health\u002Fpneumonia.html\nUNO (2015). Sustainable Development Goals (SDG). [Internet]. Available from: http:\u002F\u002Fwww.un.org\u002Fsustainabledevelopment\u002Fhealth\u002F\nWorld Health Organization and UNICEF. Fulfilling the health agenda for the women and children. 2015. (WHO, 2014).\nFakunle AG, Ogundare JO, Adelekan AL, Bello TA. Household cooking practices as risk factor for acute respiratory infections among hospitalized under-5 children in Ibadan, Nigeria. IOSR J Environ Sci Toxicol Food Technol. 2017;11(1):60–5.\nLee SW, Yon DK, James CC, Lee S, et al. Short-term effects of multiple outdoor environmental factors on risk of asthma exacerbations: age-stratified time-series analysis. J Allergy Clin Immunol. 2019;144(6):1542–50.",{"VOID":1673},"10.1186\u002Fs12890-021-01548-w","2024-06-24T20:29:35.034+00:00","https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-021-01548-w",[1677,1694,1709,1726,1741,1756,1769,1782,1796,1810,1823,1836,1850,1864,1879],{"id":1678,"sortIndex":19,"researcher":18,"roles":1679,"affiliations":1680,"properties":1689,"displayName":1691,"givenName":18,"familyName":18},"cc9e5514-bb04-4651-bff3-86b2402d7286",[187],[1681],{"id":1682,"sortIndex":19,"affiliation":1683,"properties":18},"a63a5567-4f3c-4c93-8bb7-393f20a40c22",{"id":1682,"createTime":18,"updateTime":18,"relativeEntities":1684,"slug":18,"properties":1685,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1688,"statistic":18},[],{"title":1686},{"VI":1687},"Department of Health Systems and Policy, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia",[],{"title":1690,"gsAuthor":1692},{"VI":1691},"Muluken Genetu Chanie",{"VOID":1693},"[\"mFyzLioAAAAJ\"]",{"id":1695,"sortIndex":137,"researcher":18,"roles":1696,"affiliations":1697,"properties":1706,"displayName":1708,"givenName":18,"familyName":18},"8449cbec-de92-40fe-802f-05ce0883273f",[187],[1698],{"id":1699,"sortIndex":19,"affiliation":1700,"properties":18},"df4a44a0-d47d-4719-9cd3-3dadde005e03",{"id":1699,"createTime":18,"updateTime":18,"relativeEntities":1701,"slug":18,"properties":1702,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1705,"statistic":18},[],{"title":1703},{"VI":1704},"Department of Health Informatics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia",[],{"title":1707},{"VI":1708},"Mequannent Sharew Melaku",{"id":1710,"sortIndex":217,"researcher":18,"roles":1711,"affiliations":1712,"properties":1721,"displayName":1723,"givenName":18,"familyName":18},"8c760c47-9376-4c98-a592-388f71734306",[187],[1713],{"id":1714,"sortIndex":19,"affiliation":1715,"properties":18},"036bbc17-a007-46f8-996e-51f60e510e30",{"id":1714,"createTime":18,"updateTime":18,"relativeEntities":1716,"slug":18,"properties":1717,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1720,"statistic":18},[],{"title":1718},{"VI":1719},"Department of Reproductive Health, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia",[],{"title":1722,"gsAuthor":1724},{"VI":1723},"Melaku Yalew",{"VOID":1725},"[\"f2JNuHMAAAAJ\"]",{"id":1727,"sortIndex":96,"researcher":18,"roles":1728,"affiliations":1729,"properties":1736,"displayName":1738,"givenName":18,"familyName":18},"d02fb345-8e78-4405-86ab-3a0e9dabf80d",[187],[1730],{"id":1714,"sortIndex":19,"affiliation":1731,"properties":18},{"id":1714,"createTime":18,"updateTime":18,"relativeEntities":1732,"slug":18,"properties":1733,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1735,"statistic":18},[],{"title":1734},{"VI":1719},[],{"title":1737,"gsAuthor":1739},{"VI":1738},"Mastewal Arefaynie",{"VOID":1740},"[\"CpaV5YwAAAAJ\"]",{"id":1742,"sortIndex":95,"researcher":18,"roles":1743,"affiliations":1744,"properties":1753,"displayName":1755,"givenName":18,"familyName":18},"bd660d19-5230-407b-b4ab-9ec26645f88b",[187],[1745],{"id":1746,"sortIndex":19,"affiliation":1747,"properties":18},"b178c639-50a1-4c14-b546-bc011a0c6df7",{"id":1746,"createTime":18,"updateTime":18,"relativeEntities":1748,"slug":18,"properties":1749,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1752,"statistic":18},[],{"title":1750},{"EN":1751},"Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia",[],{"title":1754},{"VI":1755},"Gedamnesh Bitew",{"id":1757,"sortIndex":400,"researcher":18,"roles":1758,"affiliations":1759,"properties":1766,"displayName":1768,"givenName":18,"familyName":18},"a49f6675-26e1-404c-a8e1-cffd7c9694d0",[187],[1760],{"id":1746,"sortIndex":19,"affiliation":1761,"properties":18},{"id":1746,"createTime":18,"updateTime":18,"relativeEntities":1762,"slug":18,"properties":1763,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1765,"statistic":18},[],{"title":1764},{"EN":1751},[],{"title":1767},{"VI":1768},"Erkihun Tadesse Amsalu",{"id":1770,"sortIndex":853,"researcher":18,"roles":1771,"affiliations":1772,"properties":1779,"displayName":1781,"givenName":18,"familyName":18},"6e2c3d73-2bd4-421d-a821-b821e76ee189",[187],[1773],{"id":1714,"sortIndex":19,"affiliation":1774,"properties":18},{"id":1714,"createTime":18,"updateTime":18,"relativeEntities":1775,"slug":18,"properties":1776,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1778,"statistic":18},[],{"title":1777},{"VI":1719},[],{"title":1780},{"VI":1781},"Bereket Kefale",{"id":1783,"sortIndex":1784,"researcher":18,"roles":1785,"affiliations":1786,"properties":1793,"displayName":1795,"givenName":18,"familyName":18},"b4af665b-b54b-4c83-a00d-8be6bd26dd33",7,[187],[1787],{"id":1746,"sortIndex":19,"affiliation":1788,"properties":18},{"id":1746,"createTime":18,"updateTime":18,"relativeEntities":1789,"slug":18,"properties":1790,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1792,"statistic":18},[],{"title":1791},{"EN":1751},[],{"title":1794},{"VI":1795},"Amare Muche",{"id":1797,"sortIndex":1798,"researcher":18,"roles":1799,"affiliations":1800,"properties":1807,"displayName":1809,"givenName":18,"familyName":18},"1d164624-b3c5-4918-a42d-c85df76d3f97",8,[187],[1801],{"id":1746,"sortIndex":19,"affiliation":1802,"properties":18},{"id":1746,"createTime":18,"updateTime":18,"relativeEntities":1803,"slug":18,"properties":1804,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1806,"statistic":18},[],{"title":1805},{"EN":1751},[],{"title":1808},{"VI":1809},"Zinabu Fentaw",{"id":1811,"sortIndex":1238,"researcher":18,"roles":1812,"affiliations":1813,"properties":1820,"displayName":1822,"givenName":18,"familyName":18},"e71bfde4-aae6-4b25-9d31-561303a1c648",[187],[1814],{"id":1746,"sortIndex":19,"affiliation":1815,"properties":18},{"id":1746,"createTime":18,"updateTime":18,"relativeEntities":1816,"slug":18,"properties":1817,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1819,"statistic":18},[],{"title":1818},{"EN":1751},[],{"title":1821},{"VI":1822},"Reta Dewau",{"id":1824,"sortIndex":97,"researcher":18,"roles":1825,"affiliations":1826,"properties":1833,"displayName":1835,"givenName":18,"familyName":18},"849f1686-3443-45eb-b571-bc6d0d64e593",[187],[1827],{"id":1746,"sortIndex":19,"affiliation":1828,"properties":18},{"id":1746,"createTime":18,"updateTime":18,"relativeEntities":1829,"slug":18,"properties":1830,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1832,"statistic":18},[],{"title":1831},{"EN":1751},[],{"title":1834},{"VI":1835},"Bezawit Adane",{"id":1837,"sortIndex":1838,"researcher":18,"roles":1839,"affiliations":1840,"properties":1847,"displayName":1849,"givenName":18,"familyName":18},"0b4d6802-cab9-4f0c-ab37-90a7315f76af",11,[187],[1841],{"id":1714,"sortIndex":19,"affiliation":1842,"properties":18},{"id":1714,"createTime":18,"updateTime":18,"relativeEntities":1843,"slug":18,"properties":1844,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1846,"statistic":18},[],{"title":1845},{"VI":1719},[],{"title":1848},{"VI":1849},"Yitayish Damtie",{"id":1851,"sortIndex":1852,"researcher":18,"roles":1853,"affiliations":1854,"properties":1861,"displayName":1863,"givenName":18,"familyName":18},"3161ab38-1f2b-4eb7-960b-767f3edd8121",12,[187],[1855],{"id":1746,"sortIndex":19,"affiliation":1856,"properties":18},{"id":1746,"createTime":18,"updateTime":18,"relativeEntities":1857,"slug":18,"properties":1858,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1860,"statistic":18},[],{"title":1859},{"EN":1751},[],{"title":1862},{"VI":1863},"Wolde Melese Ayele",{"id":1865,"sortIndex":99,"researcher":18,"roles":1866,"affiliations":1867,"properties":1876,"displayName":1878,"givenName":18,"familyName":18},"893b0ba0-5daf-4de3-b9a2-41c113c95436",[187],[1868],{"id":1869,"sortIndex":19,"affiliation":1870,"properties":18},"9f8a02cc-baf3-4e00-b06f-5ae8ba880e4e",{"id":1869,"createTime":18,"updateTime":18,"relativeEntities":1871,"slug":18,"properties":1872,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1875,"statistic":18},[],{"title":1873},{"VI":1874},"Department of Medical Laboratory Science, Dembya Primary Hospital, Gondar, Ethiopia",[],{"title":1877},{"VI":1878},"Gojjam Eshetie Ewunetie",{"id":1880,"sortIndex":1881,"researcher":18,"roles":1882,"affiliations":1883,"properties":1892,"displayName":1894,"givenName":18,"familyName":18},"b46af471-cabf-4f9c-9ba5-cac2c6f05cce",14,[187],[1884],{"id":1885,"sortIndex":19,"affiliation":1886,"properties":18},"3bf586f7-122f-4f41-beb2-a05e18c2f817",{"id":1885,"createTime":18,"updateTime":18,"relativeEntities":1887,"slug":18,"properties":1888,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1891,"statistic":18},[],{"title":1889},{"VI":1890},"Department of Environmental Health Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia",[],{"title":1893},{"VI":1894},"Metadel Adane",{"url":1675,"publisher":1896,"properties":1937},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1897,"slug":10,"properties":1898,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1901,"manageAffiliations":1906,"indexDatabases":1917,"url":18,"thumbnailPath":18,"statistic":1932,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1899,"eissn":1900},{"EN":13},{"VOID":15},[1902],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1903,"label":1904,"description":1905,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[1907,1912],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":1908,"slug":18,"properties":1909,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1911,"statistic":18},[],{"title":1910},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":1913,"slug":18,"properties":1914,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1916,"statistic":18},[],{"title":1915},{"EN":40},[],[1918,1925],{"id":61,"indexDatabase":1919,"url":72,"indexYears":73,"academicFieldIds":1924,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":1920,"label":1921,"description":1922,"key":69,"publicationTags":1923,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":1926,"url":57,"indexYears":18,"academicFieldIds":1931,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":1927,"label":1928,"description":1929,"key":53,"publicationTags":1930,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":1933,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":1934,"totalCitation":116,"totalCitationByYear":1935,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":1936,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"pages":1938,"volume":1939},{"VOID":1069},{"VOID":1071},{"total":19,"publishYear":1073,"statisticByYear":1941},{},"2021-05-25","2026-07-26T01:34:33.343+00:00",[55,76],{"id":1946,"createTime":1947,"updateTime":1948,"relativeEntities":1949,"slug":1950,"properties":1951,"entityType":176,"verifyStatus":177,"verifyTime":1964,"verifyNote":179,"languages":1965,"translateLanguages":18,"viewCount":19,"primaryUrl":1966,"fullTextUrl":18,"authors":1967,"publicationType":259,"publisherRelationship":2038,"citationCount":2085,"citationInfo":2086,"publishDate":2089,"publishYear":2087,"citationAnalyzeStatus":916,"lastCitationAnalyze":2090,"indexDatabases":2091,"openAccess":18,"references":2092,"isForceReanalyzing":310},"dd1cb4ec-8c3d-4410-8159-515c456dd529","2024-04-19T10:25:33.159+00:00","2026-07-23T22:39:33.356+00:00",[],"Sevoflurane-anesthesia-ameliorates-LPS-induced-acute-lung-injury-ALI-by-modulating-a-novel-LncRNA-LINC00839-miR-223-NLRP3-axis",{"openalex":1952,"abstract":1954,"title":1956,"gsPaper":1958,"pm":1960,"doi":1962},{"VOID":1953},"W4225001830",{"EN":1955},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\n                \u003Cjats:title>Background\u003C\u002Fjats:title>\n                \u003Cjats:p>Sevoflurane is considered as a lung-protective factor in acute lung injury (ALI), but the underlying molecular mechanism remains largely unknown. The present study identified for the first time that sevoflurane ameliorated lipopolysaccharide (LPS)-induced ALI through regulating a novel long non-coding RNA LINC00839, and uncovered its regulatory mechanism.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Methods\u003C\u002Fjats:title>\n                \u003Cjats:p>LPS-induced ALI models were established in mice or mouse pulmonary microvascular endothelial cells (MPVECs), and they were administered with sevoflurane. Real-Time quantitative PCR, western blot and bioinformatics analysis were performed to screen the aberrantly expressed long non-coding RNA and the downstream molecules in sevoflurane-treated ALI models, and their roles in the protection effect of sevoflurane were verified by functional recovery experiments.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Results\u003C\u002Fjats:title>\n                \u003Cjats:p>Sevoflurane relieved LPS-induced lung injury, cell pyroptosis and inflammation in vitro and in vivo. LINC00839 was significantly suppressed by sevoflurane, and overexpression of LINC00839 abrogated the protective effects of sevoflurane on LPS-treated MPVECs. Mechanismly, LINC00839 positively regulated NOD-like receptor protein 3 (NLRP3) via sequestering miR-223. MiR-223 inhibitor reversed the inhibitory effects of LINC00839 knockdown on NLRP3-mediated pyroptosis in LPS-treated MPVECs. Furthermore, both miR-223 ablation and NLRP3 overexpression abrogated the protective effects of sevoflurane on LPS-treated MPVECs.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n                \u003Cjats:p>In general, our work illustrates that sevoflurane regulates the LINC00839\u002FmiR-223\u002FNLRP3 axis to ameliorate LPS-induced ALI, which might provide a novel promising candidate for the prevention of ALI.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>",{"EN":1957},"Sevoflurane anesthesia ameliorates LPS-induced acute lung injury (ALI) by modulating a novel LncRNA LINC00839\u002FmiR-223\u002FNLRP3 axis",{"VOID":1959},"[\"16005851310899081247\"]",{"VOID":1961},"35473680",{"VOID":1963},"10.1186\u002Fs12890-022-01957-5","2024-06-25T03:31:59.353+00:00",[482],"https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-022-01957-5",[1968,1987,2004,2021],{"id":1969,"sortIndex":19,"researcher":18,"roles":1970,"affiliations":1971,"properties":1980,"displayName":1984,"givenName":18,"familyName":18},"5c531307-921b-465d-ac2c-8d74485f391f",[],[1972],{"id":1973,"sortIndex":19,"affiliation":1974,"properties":18},"c0c636ad-096f-4a8e-8087-2600f123f3f8",{"id":1973,"createTime":18,"updateTime":18,"relativeEntities":1975,"slug":18,"properties":1976,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1979,"statistic":18},[],{"title":1977},{"VI":1978},"Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning, China",[],{"orcid":1981,"title":1983,"openalex":1985},{"VOID":1982},"https:\u002F\u002Forcid.org\u002F0000-0003-2024-4910",{"EN":1984},"Zhiling Fu",{"VOID":1986},"A5013917402",{"id":1988,"sortIndex":137,"researcher":18,"roles":1989,"affiliations":1990,"properties":1997,"displayName":2001,"givenName":18,"familyName":18},"f0dc753c-cb83-4396-8e9c-e52b8b6deb0a",[],[1991],{"id":1973,"sortIndex":19,"affiliation":1992,"properties":18},{"id":1973,"createTime":18,"updateTime":18,"relativeEntities":1993,"slug":18,"properties":1994,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1996,"statistic":18},[],{"title":1995},{"VI":1978},[],{"orcid":1998,"title":2000,"openalex":2002},{"VOID":1999},"https:\u002F\u002Forcid.org\u002F0000-0002-4466-5122",{"EN":2001},"Xiuying Wu",{"VOID":2003},"A5048419366",{"id":2005,"sortIndex":217,"researcher":18,"roles":2006,"affiliations":2007,"properties":2016,"displayName":2018,"givenName":18,"familyName":18},"c13ccad8-3019-4b1e-b25e-1dde8ddd599c",[],[2008],{"id":2009,"sortIndex":19,"affiliation":2010,"properties":18},"ab9d147b-fd19-495b-b066-0652b1c08976",{"id":2009,"createTime":18,"updateTime":18,"relativeEntities":2011,"slug":18,"properties":2012,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2015,"statistic":18},[],{"title":2013},{"VI":2014},"Department of Thoracic Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning, China",[],{"title":2017,"openalex":2019},{"EN":2018},"Fushuang Zheng",{"VOID":2020},"A5085339150",{"id":2022,"sortIndex":96,"researcher":18,"roles":2023,"affiliations":2024,"properties":2031,"displayName":2035,"givenName":18,"familyName":18},"478f066f-1cb4-4765-b356-a4fdf65c61da",[],[2025],{"id":1973,"sortIndex":19,"affiliation":2026,"properties":18},{"id":1973,"createTime":18,"updateTime":18,"relativeEntities":2027,"slug":18,"properties":2028,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2030,"statistic":18},[],{"title":2029},{"VI":1978},[],{"orcid":2032,"title":2034,"openalex":2036},{"VOID":2033},"https:\u002F\u002Forcid.org\u002F0000-0002-9215-3842",{"EN":2035},"Yan Zhang",{"VOID":2037},"A5086664284",{"url":18,"publisher":2039,"properties":2080},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2040,"slug":10,"properties":2041,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":2044,"manageAffiliations":2049,"indexDatabases":2060,"url":18,"thumbnailPath":18,"statistic":2075,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":2042,"eissn":2043},{"EN":13},{"VOID":15},[2045],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":2046,"label":2047,"description":2048,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[2050,2055],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":2051,"slug":18,"properties":2052,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2054,"statistic":18},[],{"title":2053},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":2056,"slug":18,"properties":2057,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2059,"statistic":18},[],{"title":2058},{"EN":40},[],[2061,2068],{"id":61,"indexDatabase":2062,"url":72,"indexYears":73,"academicFieldIds":2067,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":2063,"label":2064,"description":2065,"key":69,"publicationTags":2066,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":2069,"url":57,"indexYears":18,"academicFieldIds":2074,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":2070,"label":2071,"description":2072,"key":53,"publicationTags":2073,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":2076,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":2077,"totalCitation":116,"totalCitationByYear":2078,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":2079,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"issue":2081,"volume":2083},{"VOID":2082},"1",{"VOID":2084},"22",15,{"total":2085,"publishYear":2087,"statisticByYear":2088},2022,{"2022":137,"2023":95,"2024":853,"2025":217,"2026":217},"2022-12-01","2026-07-23T22:39:33.355+00:00",[55,76],[2093,2097,2101,2105,2109,2113,2117,2121,2125,2129,2133,2137,2141,2145,2149,2153,2157,2161,2165,2169,2173,2177,2181,2185,2189,2193,2197,2201,2205,2209,2212,2216,2220,2224,2228,2232,2236,2240,2244,2248,2252,2256,2259,2263,2267,2271,2275,2279,2283,2287,2291,2295,2299,2303,2307,2311,2315,2319],{"id":18,"text":2094,"url":18,"identifiers":2095},"Li C, Liu JH, Su J, Lin WJ, Zhao JQ, Zhang ZH, et al. LncRNA XIST knockdown alleviates LPS-induced acute lung injury by inactivation of XIST\u002FmiR-132–3p\u002FMAPK14 pathway: XIST promotes ALI via miR-132–3p\u002FMAPK14 axis. Mol Cell Biochem. 2021. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11010-021-04234-x.",{"doi":2096},"10.1007\u002Fs11010-021-04234-x",{"id":18,"text":2098,"url":18,"identifiers":2099},"Liao H, Zhang S, Qiao J. Silencing of long non-coding RNA MEG3 alleviates lipopolysaccharide-induced acute lung injury by acting as a molecular sponge of microRNA-7b to modulate NLRP3. Aging (Albany NY). 2020;12(20):20198–211. https:\u002F\u002Fdoi.org\u002F10.1863\u002Faging.103752.",{"doi":2100},"10.1863\u002Faging.103752",{"id":18,"text":2102,"url":18,"identifiers":2103},"Teng X, Liao J, Zhao L, Dong W, Xue H, Bai L, et al. Whole transcriptome analysis of the differential RNA profiles and associated competing endogenous RNA networks in LPS-induced acute lung injury (ALI). PLoS ONE. 2021;16(5): e0251359. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0251359.",{"doi":2104},"10.1371\u002Fjournal.pone.0251359",{"id":18,"text":2106,"url":18,"identifiers":2107},"Oshima Y, Otsuki A, Endo R, Nakasone M, Harada T, Takahashi S, et al. The effects of volatile anesthetics on lung ischemia-reperfusion injury: basic to clinical studies. J Surg Res. 2021;260:325–44. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jss.2020.11.042.",{"doi":2108},"10.1016\u002Fj.jss.2020.11.042",{"id":18,"text":2110,"url":18,"identifiers":2111},"Qiao SG, Sun Y, Sun B, Wang A, Qiu J, Hong L, et al. Sevoflurane postconditioning protects against myocardial ischemia\u002Freperfusion injury by restoring autophagic flux via an NO-dependent mechanism. Acta Pharmacol Sin. 2019;40(1):35–45. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41401-018-0066-y.",{"doi":2112},"10.1038\u002Fs41401-018-0066-y",{"id":18,"text":2114,"url":18,"identifiers":2115},"Shi CX, Jin J, Wang XQ, Song T, Li GH, Li KZ, et al. Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia-reperfusion rats. Mol Med Rep. 2020;21(1):123–30. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fmmr.2019.10832.",{"doi":2116},"10.3892\u002Fmmr.2019.10832",{"id":18,"text":2118,"url":18,"identifiers":2119},"Yu F, Tong LJ, Cai DS. Sevoflurane inhibits neuronal apoptosis and expressions of HIF-1 and HSP70 in brain tissues of rats with cerebral ischemia\u002Freperfusion injury. Eur Rev Med Pharmacol Sci. 2020;24(9):5082–90. https:\u002F\u002Fdoi.org\u002F10.26355\u002Feurrev_202005_21201.",{"doi":2120},"10.26355\u002Feurrev_202005_21201",{"id":18,"text":2122,"url":18,"identifiers":2123},"Kellner P, Müller M, Piegeler T, Eugster P, Booy C, Schläpfer M, et al. Sevoflurane abolishes oxygenation impairment in a long-term rat model of acute lung injury. Anesth Analg. 2017;124(1):194–203. https:\u002F\u002Fdoi.org\u002F10.1213\u002Fane.0000000000001530.",{"doi":2124},"10.1213\u002Fane.0000000000001530",{"id":18,"text":2126,"url":18,"identifiers":2127},"Wang L, Ye Y, Su HB, Yang JP. The anesthetic agent sevoflurane attenuates pulmonary acute lung injury by modulating apoptotic pathways. Braz J Med Biol Res. 2017;50(3): e5747. https:\u002F\u002Fdoi.org\u002F10.1590\u002F1414-431x20165747.",{"doi":2128},"10.1590\u002F1414-431x20165747",{"id":18,"text":2130,"url":18,"identifiers":2131},"Wang L, Zha B, Shen Q, Zou H, Cheng C, Wu H, et al. Sevoflurane inhibits the Th2 response and NLRP3 expression in murine allergic airway inflammation. J Immunol Res. 2018;2018:902–1037. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2018\u002F9021037.",{"doi":2132},"10.1155\u002F2018\u002F9021037",{"id":18,"text":2134,"url":18,"identifiers":2135},"Wang Y, Zhang X, Tian J, Liu G, Li X, Shen D. Sevoflurane alleviates LPS-induced acute lung injury via the microRNA-27a-3p\u002FTLR4\u002FMyD88\u002FNF-κB signaling pathway. Int J Mol Med. 2019;44(2):479–90. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fijmm.2019.4217.",{"doi":2136},"10.3892\u002Fijmm.2019.4217",{"id":18,"text":2138,"url":18,"identifiers":2139},"Chen J, Wang S, Fu R, Zhou M, Zhang T, Pan W, et al. RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice. J Transl Med. 2018;16(1):233. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12967-018-1606-4.",{"doi":2140},"10.1186\u002Fs12967-018-1606-4",{"id":18,"text":2142,"url":18,"identifiers":2143},"Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, et al. Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma. Am J Respir Crit Care Med. 2017;196(3):283–97. https:\u002F\u002Fdoi.org\u002F10.1164\u002Frccm.201609-1830OC.",{"doi":2144},"10.1164\u002Frccm.201609-1830OC",{"id":18,"text":2146,"url":18,"identifiers":2147},"Li Y, Li H, Liu S, Pan P, Su X, Tan H, et al. Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation. Mol Immunol. 2018;99:134–44. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.molimm.2018.05.003.",{"doi":2148},"10.1016\u002Fj.molimm.2018.05.003",{"id":18,"text":2150,"url":18,"identifiers":2151},"Hou L, Yang Z, Wang Z, Zhang X, Zhao Y, Yang H, et al. NLRP3\u002FASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass. Lab Investig. 2018;98(8):1052–64. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41374-018-0073-0.",{"doi":2152},"10.1038\u002Fs41374-018-0073-0",{"id":18,"text":2154,"url":18,"identifiers":2155},"Huang H, Wang J, Liu Z, Gao F. The angiotensin-converting enzyme 2\u002Fangiotensin (1–7)\u002Fmas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation. Arch Biochem Biophys. 2020;693:108562. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.abb.2020.108562.",{"doi":2156},"10.1016\u002Fj.abb.2020.108562",{"id":18,"text":2158,"url":18,"identifiers":2159},"Ji J, Ye W, Sun G. LncRNA OIP5-AS1 knockdown or miR-223 overexpression can alleviate LPS-induced ALI\u002FARDS by interfering with miR-223\u002FNLRP3-mediated pyroptosis. J Gene Med. 2021;24:e3385. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjgm.3385.",{"doi":2160},"10.1002\u002Fjgm.3385",{"id":18,"text":2162,"url":18,"identifiers":2163},"Ning L, Wei W, Wenyang J, Rui X, Qing G. Cytosolic DNA-STING-NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide. Clin Transl Med. 2020;10(7): e228. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fctm2.228.",{"doi":2164},"10.1002\u002Fctm2.228",{"id":18,"text":2166,"url":18,"identifiers":2167},"Jiang N, Meng X, Mi H, Chi Y, Li S, Jin Z, et al. Circulating lncRNA XLOC_009167 serves as a diagnostic biomarker to predict lung cancer. Clin Chim Acta. 2018;486:26–33. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cca.2018.07.026.",{"doi":2168},"10.1016\u002Fj.cca.2018.07.026",{"id":18,"text":2170,"url":18,"identifiers":2171},"Kong X, Duan Y, Sang Y, Li Y, Zhang H, Liang Y, et al. LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215. J Cell Physiol. 2019;234(6):9105–17. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjcp.27587.",{"doi":2172},"10.1002\u002Fjcp.27587",{"id":18,"text":2174,"url":18,"identifiers":2175},"Zhou H, Wang X, Zhang B. Depression of lncRNA NEAT1 antagonizes LPS-evoked acute injury and inflammatory response in alveolar epithelial cells via HMGB1-RAGE signaling. Mediat Inflamm. 2020. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2020\u002F8019467.",{"doi":2176},"10.1155\u002F2020\u002F8019467",{"id":18,"text":2178,"url":18,"identifiers":2179},"Qiu N, Xu X, He Y. LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p\u002FGAB1. BMC Pulm Med. 2020;20(1):49. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12890-020-1084-3.",{"doi":2180},"10.1186\u002Fs12890-020-1084-3",{"id":18,"text":2182,"url":18,"identifiers":2183},"Zhang Y, Guo H, Ma L, Chen X, Chen G. Long noncoding RNA LINC00839 promotes the malignant progression of osteosarcoma by competitively binding to MicroRNA-454–3p and consequently increasing c-Met expression. Cancer Manag Res. 2020;12:8975–87. https:\u002F\u002Fdoi.org\u002F10.2147\u002Fcmar.S269774.",{"doi":2184},"10.2147\u002Fcmar.S269774",{"id":18,"text":2186,"url":18,"identifiers":2187},"Yang L, Pei L, Yi J. LINC00839 regulates proliferation, migration, invasion, apoptosis and glycolysis in neuroblastoma cells through miR-338–3p\u002FGLUT1 axis. Neuropsychiatr Dis Treat. 2021;17:2027–40. https:\u002F\u002Fdoi.org\u002F10.2147\u002Fndt.S309467.",{"doi":2188},"10.2147\u002Fndt.S309467",{"id":18,"text":2190,"url":18,"identifiers":2191},"Zhou X, Chang Y, Zhu L, Shen C, Qian J, Chang R. LINC00839\u002FmiR-144-3p\u002FWTAP (WT1 Associated Protein) axis is involved in regulating hepatocellular carcinoma progression. Bioengineered. 2021. https:\u002F\u002Fdoi.org\u002F10.1080\u002F21655979.2021.1990578.",{"doi":2192},"10.1080\u002F21655979.2021.1990578",{"id":18,"text":2194,"url":18,"identifiers":2195},"Long FQ, Kou CX, Li K, Wu J, Wang QQ. MiR-223-3p inhibits rTp17-induced inflammasome activation and pyroptosis by targeting NLRP3. J Cell Mol Med. 2020;24(24):14405–14. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjcmm.16061.",{"doi":2196},"10.1111\u002Fjcmm.16061",{"id":18,"text":2198,"url":18,"identifiers":2199},"Zhang D, Lee H, Wang X, Groot M, Sharma L, Dela Cruz CS, et al. A potential role of microvesicle-containing miR-223\u002F142 in lung inflammation. Thorax. 2019;74(9):865–74. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fthoraxjnl-2018-212994.",{"doi":2200},"10.1136\u002Fthoraxjnl-2018-212994",{"id":18,"text":2202,"url":18,"identifiers":2203},"Feng Z, Qi S, Zhang Y, Qi Z, Yan L, Zhou J, et al. Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury. Cell Death Dis. 2017;8(11): e3170. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fcddis.2017.549.",{"doi":2204},"10.1038\u002Fcddis.2017.549",{"id":18,"text":2206,"url":18,"identifiers":2207},"Yan Y, Lu K, Ye T, Zhang Z. MicroRNA-223 attenuates LPS-induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4\u002FNF-κB signaling pathway via RHOB. Int J Mol Med. 2019;43(3):1467–77. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fijmm.2019.4075.",{"doi":2208},"10.3892\u002Fijmm.2019.4075",{"id":18,"text":2210,"url":18,"identifiers":2211},"Tang QF, Fang ZY, Shi CH. The protective effect and mechanism of sevoflurane on LPS-induced acute lung injury in mice. Am J Transl Res. 2017;9(4):1732–42.",{},{"id":18,"text":2213,"url":18,"identifiers":2214},"Yuan J, Zhang Y. Sevoflurane reduces inflammatory factor expression, increases viability and inhibits apoptosis of lung cells in acute lung injury by microRNA-34a-3p upregulation and STAT1 downregulation. Chem Biol Interact. 2020;322:109027. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cbi.2020.109027.",{"doi":2215},"10.1016\u002Fj.cbi.2020.109027",{"id":18,"text":2217,"url":18,"identifiers":2218},"Yang H, Lv H, Li H, Ci X, Peng L. Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways. Cell Commun Signal. 2019;17(1):62. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12964-019-0366-y.",{"doi":2219},"10.1186\u002Fs12964-019-0366-y",{"id":18,"text":2221,"url":18,"identifiers":2222},"Barreto TR, Costola-de-Souza C, Margatho RO, Queiroz-Hazarbassanov N, Rodrigues SC, Felício LF, et al. Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice. Int Immunopharmacol. 2018;56:43–50. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.intimp.2018.01.009.",{"doi":2223},"10.1016\u002Fj.intimp.2018.01.009",{"id":18,"text":2225,"url":18,"identifiers":2226},"Sahu B, Narota A, Naura AS. Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib, prevents acute lung injury associated cognitive deficits potentially through suppression of inflammatory response. Eur J Pharmacol. 2020;877:173091. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ejphar.2020.173091.",{"doi":2227},"10.1016\u002Fj.ejphar.2020.173091",{"id":18,"text":2229,"url":18,"identifiers":2230},"Li T, Wu YN, Wang H, Ma JY, Zhai SS, Duan J. Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK\u002FNF-κB signaling pathway. Mol Immunol. 2020;120:13–22. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.molimm.2020.01.014.",{"doi":2231},"10.1016\u002Fj.molimm.2020.01.014",{"id":18,"text":2233,"url":18,"identifiers":2234},"Liu Z, Yang B. CTRP6(C1q\u002FTumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt). Bioengineered. 2021;12(1):5716–26. https:\u002F\u002Fdoi.org\u002F10.1080\u002F21655979.2021.1967838.",{"doi":2235},"10.1080\u002F21655979.2021.1967838",{"id":18,"text":2237,"url":18,"identifiers":2238},"Wang J, Du A, Wang H, Li Y. MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2\u002FSTAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells. Clin Exp Pharmacol Physiol. 2020;47(8):1420–8. https:\u002F\u002Fdoi.org\u002F10.1111\u002F1440-1681.13316.",{"doi":2239},"10.1111\u002F1440-1681.13316",{"id":18,"text":2241,"url":18,"identifiers":2242},"Li T, Xiao G, Tan S, Shi X, Yin L, Tan C, et al. HSF1 attenuates LPS-induced acute lung injury in mice by suppressing macrophage infiltration. Oxid Med Cell Longev. 2020;2020:1936580. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2020\u002F1936580.",{"doi":2243},"10.1155\u002F2020\u002F1936580",{"id":18,"text":2245,"url":18,"identifiers":2246},"Zhou Q, Zhang L. MicroRNA-183-5p protects human derived cell line SH-SY5Y cells from mepivacaine-induced injury. Bioengineered. 2021;12(1):3177–87. https:\u002F\u002Fdoi.org\u002F10.1080\u002F21655979.2021.1946358.",{"doi":2247},"10.1080\u002F21655979.2021.1946358",{"id":18,"text":2249,"url":18,"identifiers":2250},"Hou Q, Li S, Zhang B, Chu H, Ni C, Fei X, et al. LncRNA riken attenuated sevoflurane-induced neuroinflammation by regulating the MicroRNA-101a\u002FMKP-1\u002FJNK pathway. Neurotox Res. 2021. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12640-021-00443-w.",{"doi":2251},"10.1007\u002Fs12640-021-00443-w",{"id":18,"text":2253,"url":18,"identifiers":2254},"Wei X, Xu S, Chen L. LncRNA Neat1\u002FmiR-298-5p\u002FSrpk1 contributes to sevoflurane-induced neurotoxicity. Neurochem Res. 2021;46(12):3356–64. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11064-021-03436-5.",{"doi":2255},"10.1007\u002Fs11064-021-03436-5",{"id":18,"text":2257,"url":18,"identifiers":2258},"Xu W, Zhao Y, Ai Y. Overexpression of lncRNA Gm43050 alleviates apoptosis and inflammation response induced by sevoflurane treatment by regulating miR-640\u002FZFP91. Am J Transl Res. 2020;12(8):4337–46.",{},{"id":18,"text":2260,"url":18,"identifiers":2261},"Li Y, Huang J, Foley NM, Xu Y, Li YP, Pan J, et al. B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration. Sci Rep. 2016. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsrep31284.",{"doi":2262},"10.1038\u002Fsrep31284",{"id":18,"text":2264,"url":18,"identifiers":2265},"Rajasekaran S, Pattarayan D, Rajaguru P, Sudhakar Gandhi PS, Thimmulappa RK. MicroRNA regulation of acute lung injury and acute respiratory distress syndrome. J Cell Physiol. 2016;231(10):2097–106. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjcp.25316.",{"doi":2266},"10.1002\u002Fjcp.25316",{"id":18,"text":2268,"url":18,"identifiers":2269},"Spadaro S, Park M, Turrini C, Tunstall T, Thwaites R, Mauri T, et al. Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine. J Inflamm (Lond). 2019. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12950-018-0202-y.",{"doi":2270},"10.1186\u002Fs12950-018-0202-y",{"id":18,"text":2272,"url":18,"identifiers":2273},"Huang X, Xiu H, Zhang S, Zhang G. The role of macrophages in the pathogenesis of ALI\u002FARDS. Mediat Inflamm. 2018;2018:1264913. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2018\u002F1264913.",{"doi":2274},"10.1155\u002F2018\u002F1264913",{"id":18,"text":2276,"url":18,"identifiers":2277},"Du G, Wang S, Li Z, Liu J. Sevoflurane posttreatment attenuates lung injury induced by oleic acid in dogs. Anesth Analg. 2017;124(5):1555–63. https:\u002F\u002Fdoi.org\u002F10.1213\u002Fane.0000000000002034.",{"doi":2278},"10.1213\u002Fane.0000000000002034",{"id":18,"text":2280,"url":18,"identifiers":2281},"Jabaudon M, Boucher P, Imhoff E, Chabanne R, Faure JS, Roszyk L, et al. Sevoflurane for sedation in acute respiratory distress syndrome. A randomized controlled pilot study. Am J Respir Crit Care Med. 2017;195(6):792–800. https:\u002F\u002Fdoi.org\u002F10.1164\u002Frccm.201604-0686OC.",{"doi":2282},"10.1164\u002Frccm.201604-0686OC",{"id":18,"text":2284,"url":18,"identifiers":2285},"Chen Q, Shen H, Zhu X, Liu Y, Yang H, Chen H, et al. A nuclear lncRNA Linc00839 as a Myc target to promote breast cancer chemoresistance via PI3K\u002FAKT signaling pathway. Cancer Sci. 2020;111(9):3279–91. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fcas.14555.",{"doi":2286},"10.1111\u002Fcas.14555",{"id":18,"text":2288,"url":18,"identifiers":2289},"Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, et al. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med. 2017;214(6):1737–52. https:\u002F\u002Fdoi.org\u002F10.1084\u002Fjem.20160462.",{"doi":2290},"10.1084\u002Fjem.20160462",{"id":18,"text":2292,"url":18,"identifiers":2293},"Sha R, Zhang B, Han X, Peng J, Zheng C, Zhang F, et al. Electroacupuncture alleviates ischemic brain injury by inhibiting the miR-223\u002FNLRP3 pathway. Med Sci Monit. 2019;25:4723–33. https:\u002F\u002Fdoi.org\u002F10.12659\u002Fmsm.917213.",{"doi":2294},"10.12659\u002Fmsm.917213",{"id":18,"text":2296,"url":18,"identifiers":2297},"Wu X, Pan S, Luo W, Shen Z, Meng X, Xiao M, et al. Roseburia intestinalis-derived flagellin ameliorates colitis by targeting miR-223-3p-mediated activation of NLRP3 inflammasome and pyroptosis. Mol Med Rep. 2020;22(4):2695–704. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fmmr.2020.11351.",{"doi":2298},"10.3892\u002Fmmr.2020.11351",{"id":18,"text":2300,"url":18,"identifiers":2301},"Zhang Y, Liu X, Bai X, Lin Y, Li Z, Fu J, et al. Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3\u002FmiR-223\u002FNLRP3 axis. J Pineal Res. 2018. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjpi.12449.",{"doi":2302},"10.1111\u002Fjpi.12449",{"id":18,"text":2304,"url":18,"identifiers":2305},"Fan EKY, Fan J. Regulation of alveolar macrophage death in acute lung inflammation. Respir Res. 2018;19(1):50. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12931-018-0756-5.",{"doi":2306},"10.1186\u002Fs12931-018-0756-5",{"id":18,"text":2308,"url":18,"identifiers":2309},"Liu B, He R, Zhang L, Hao B, Jiang W, Wang W, et al. Inflammatory caspases drive pyroptosis in acute lung injury. Front Pharmacol. 2021;12:631256. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphar.2021.631256.",{"doi":2310},"10.3389\u002Ffphar.2021.631256",{"id":18,"text":2312,"url":18,"identifiers":2313},"Li D, Ren W, Jiang Z, Zhu L. Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury. Mol Med Rep. 2018;18(5):4399–409. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fmmr.2018.9427.",{"doi":2314},"10.3892\u002Fmmr.2018.9427",{"id":18,"text":2316,"url":18,"identifiers":2317},"Wallach D, Kang TB, Dillon CP, Green DR. Programmed necrosis in inflammation: toward identification of the effector molecules. Science. 2016;352(6281):aaf2154. https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.aaf2154.",{"doi":2318},"10.1126\u002Fscience.aaf2154",{"id":18,"text":2320,"url":18,"identifiers":2321},"Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 2016;535(7610):111–6. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnature18590.",{"doi":2322},"10.1038\u002Fnature18590",{"id":2324,"createTime":2325,"updateTime":2326,"relativeEntities":2327,"slug":2328,"properties":2329,"entityType":176,"verifyStatus":177,"verifyTime":2346,"verifyNote":179,"languages":2347,"translateLanguages":18,"viewCount":19,"primaryUrl":2348,"fullTextUrl":18,"authors":2349,"publicationType":259,"publisherRelationship":2450,"citationCount":19,"citationInfo":2495,"publishDate":2497,"publishYear":308,"citationAnalyzeStatus":916,"lastCitationAnalyze":2498,"indexDatabases":2499,"openAccess":18,"references":2500,"isForceReanalyzing":310},"bc945fb9-db10-41f7-8109-e389a65a854e","2024-04-18T15:18:40.379+00:00","2026-07-23T10:06:42.661+00:00",[],"Case-report-of-endoprosthesis-Y-implantation-in-severe-respiratory-failure-in-the-MPSII-patient-comparison-with-literature-data",{"mag":2330,"gsPaper":2332,"pmc":2334,"openalex":2336,"abstract":2338,"title":2340,"pm":2342,"doi":2344},{"VOID":2331},"3016865472",{"VOID":2333},"[\"6418765880562450537\"]",{"VOID":2335},"7171830",{"VOID":2337},"W3016865472",{"EN":2339},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\n\u003Cjats:title>Background\u003C\u002Fjats:title>\n\u003Cjats:p>The tracheobronchomalacia is a life-threatening complication of mucopolysaccharidosis (MPS) without known effective, optimal treatment. The severe expiratory collapse of the trachea and bronchi is one of causes of the high rate of deaths in the course of airway impairment in MPSII patients.\u003C\u002Fjats:p>\n\u003C\u002Fjats:sec>\u003Cjats:sec>\n\u003Cjats:title>Case presentation\u003C\u002Fjats:title>\n\u003Cjats:p>Due to the adynamic tracheobronchomalacia despite of enzymatic treatment (ERT) in our MPSII patient, a life-saving tracheal bifurcated type-Y endoprosthesis (a self-expanding, metal stent for the prosthesis of tracheal and bronchial stenosis) was implanted. In the followed months, the breathing efficiency improved, but then gradual worsening, progression of bronchi occlusion at the stent border resulted in patient’s death.\u003C\u002Fjats:p>\n\u003C\u002Fjats:sec>\u003Cjats:sec>\n\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n\u003Cjats:p>The Y-stent implantation appears to be a short-term, life-saving solution without satisfactory long-term effects due to the progress of peripheral bronchomalacia and increased tissue proliferation and granulation, that arises during the illness’ course.\u003C\u002Fjats:p>\n\u003C\u002Fjats:sec>",{"EN":2341},"Case report of endoprosthesis -Y implantation in severe respiratory failure in the MPSII patient; comparison with literature data",{"VOID":2343},"32312280",{"VOID":2345},"10.1186\u002Fs12890-020-1143-9","2024-05-16T23:57:15.506+00:00",[482],"https:\u002F\u002Fbmcpulmmed.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12890-020-1143-9",[2350,2367,2382,2397,2416,2433],{"id":2351,"sortIndex":19,"researcher":18,"roles":2352,"affiliations":2353,"properties":2362,"displayName":2364,"givenName":18,"familyName":18},"ee69a7d9-2e73-4ea2-a495-12b0b1f6770e",[],[2354],{"id":2355,"sortIndex":19,"affiliation":2356,"properties":18},"e697e9fa-c472-4136-a05e-f4965922cab7",{"id":2355,"createTime":18,"updateTime":18,"relativeEntities":2357,"slug":18,"properties":2358,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2361,"statistic":18},[],{"title":2359},{"EN":2360},"Department of Thoracic Surgery, John Paul II Hospital Krakow, Krakow, Poland",[],{"title":2363,"openalex":2365},{"EN":2364},"Wojciech Gocyk",{"VOID":2366},"A5071493550",{"id":2368,"sortIndex":137,"researcher":18,"roles":2369,"affiliations":2370,"properties":2377,"displayName":2379,"givenName":18,"familyName":18},"42f69c3c-5b36-4ea5-974c-2b2d0859c31e",[],[2371],{"id":2355,"sortIndex":19,"affiliation":2372,"properties":18},{"id":2355,"createTime":18,"updateTime":18,"relativeEntities":2373,"slug":18,"properties":2374,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2376,"statistic":18},[],{"title":2375},{"EN":2360},[],{"title":2378,"openalex":2380},{"EN":2379},"Janusz Warmus",{"VOID":2381},"A5017294046",{"id":2383,"sortIndex":217,"researcher":18,"roles":2384,"affiliations":2385,"properties":2392,"displayName":2394,"givenName":18,"familyName":18},"837ff0de-aad1-4c25-b836-bc0f366176ef",[],[2386],{"id":2355,"sortIndex":19,"affiliation":2387,"properties":18},{"id":2355,"createTime":18,"updateTime":18,"relativeEntities":2388,"slug":18,"properties":2389,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2391,"statistic":18},[],{"title":2390},{"EN":2360},[],{"title":2393,"openalex":2395},{"EN":2394},"H Olechnowicz",{"VOID":2396},"A5027030950",{"id":2398,"sortIndex":96,"researcher":18,"roles":2399,"affiliations":2400,"properties":2409,"displayName":2413,"givenName":18,"familyName":18},"c9b8fbaf-74f1-4d0d-ba6b-818052fee907",[],[2401],{"id":2402,"sortIndex":19,"affiliation":2403,"properties":18},"6df9890d-ad92-4f7d-ae1c-f15066c71058",{"id":2402,"createTime":18,"updateTime":18,"relativeEntities":2404,"slug":18,"properties":2405,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2408,"statistic":18},[],{"title":2406},{"EN":2407},"Clinical Department of Medical Genetics, Children University Hospital, Krakow, Poland",[],{"orcid":2410,"title":2412,"openalex":2414},{"VOID":2411},"https:\u002F\u002Forcid.org\u002F0000-0003-1542-7050",{"EN":2413},"Mirosław Bik-Multanowski",{"VOID":2415},"A5035835858",{"id":2417,"sortIndex":95,"researcher":18,"roles":2418,"affiliations":2419,"properties":2428,"displayName":2430,"givenName":18,"familyName":18},"055ddad6-67e0-4be0-8356-6204e0533d1f",[],[2420],{"id":2421,"sortIndex":19,"affiliation":2422,"properties":18},"2b8bd966-ab4b-426c-97b4-f870a858370b",{"id":2421,"createTime":18,"updateTime":18,"relativeEntities":2423,"slug":18,"properties":2424,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2427,"statistic":18},[],{"title":2425},{"EN":2426},"Clinical Department of Metabolic Diseases, University Hospital, Krakow, Poland",[],{"title":2429,"openalex":2431},{"EN":2430},"Łukasz Pawliński",{"VOID":2432},"A5024511024",{"id":2434,"sortIndex":400,"researcher":18,"roles":2435,"affiliations":2436,"properties":2443,"displayName":2447,"givenName":18,"familyName":18},"3a8b1372-9eeb-4423-aaab-0ed342c86877",[],[2437],{"id":2421,"sortIndex":19,"affiliation":2438,"properties":18},{"id":2421,"createTime":18,"updateTime":18,"relativeEntities":2439,"slug":18,"properties":2440,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2442,"statistic":18},[],{"title":2441},{"EN":2426},[],{"orcid":2444,"title":2446,"openalex":2448},{"VOID":2445},"https:\u002F\u002Forcid.org\u002F0000-0002-2526-9714",{"EN":2447},"Beata Kieć‐Wilk",{"VOID":2449},"A5011860445",{"url":18,"publisher":2451,"properties":2492},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2452,"slug":10,"properties":2453,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":2456,"manageAffiliations":2461,"indexDatabases":2472,"url":18,"thumbnailPath":18,"statistic":2487,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":2454,"eissn":2455},{"EN":13},{"VOID":15},[2457],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":2458,"label":2459,"description":2460,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},[2462,2467],{"id":29,"createTime":18,"updateTime":18,"relativeEntities":2463,"slug":18,"properties":2464,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2466,"statistic":18},[],{"title":2465},{"EN":33},[],{"id":36,"createTime":18,"updateTime":18,"relativeEntities":2468,"slug":18,"properties":2469,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2471,"statistic":18},[],{"title":2470},{"EN":40},[],[2473,2480],{"id":61,"indexDatabase":2474,"url":72,"indexYears":73,"academicFieldIds":2479,"indexDatabaseRanking":76},{"id":63,"createTime":18,"updateTime":18,"relativeEntities":2475,"label":2476,"description":2477,"key":69,"publicationTags":2478,"standard":18},[],{"EN":66,"VI":66},{"EN":66,"VI":68},[71],[75],{"id":44,"indexDatabase":2481,"url":57,"indexYears":18,"academicFieldIds":2486,"indexDatabaseRanking":18},{"id":46,"createTime":18,"updateTime":18,"relativeEntities":2482,"label":2483,"description":2484,"key":53,"publicationTags":2485,"standard":18},[],{"EN":49,"VI":49},{"EN":51,"VI":52},[55,56],[59],{"impactFactor":19,"impactFactorByYear":2488,"i10Index":91,"i10IndexLast5Year":92,"totalPublication":93,"totalPublicationByYear":2489,"totalCitation":116,"totalCitationByYear":2490,"totalCitationPerPublication":135,"totalCitationPerPublicationByYear":2491,"hindexLast5Year":155,"hindex":155},{"2012":79,"2013":80,"2014":81,"2015":82,"2016":83,"2017":84,"2018":85,"2019":86,"2020":87,"2021":88,"2022":89,"2023":90},{"2001":95,"2002":96,"2003":96,"2004":97,"2005":97,"2006":98,"2007":99,"2008":100,"2009":101,"2010":102,"2011":101,"2012":103,"2013":104,"2014":105,"2015":106,"2016":107,"2017":108,"2018":109,"2019":110,"2020":111,"2021":112,"2022":113,"2023":114,"2024":115},{"2001":95,"2004":118,"2006":119,"2007":98,"2008":120,"2009":121,"2010":122,"2011":123,"2012":124,"2013":125,"2014":126,"2015":127,"2016":128,"2017":129,"2018":130,"2019":131,"2020":132,"2021":133,"2022":134},{"2001":137,"2004":138,"2006":139,"2007":140,"2008":141,"2009":142,"2010":143,"2011":144,"2012":145,"2013":95,"2014":146,"2015":147,"2016":148,"2017":149,"2018":150,"2019":151,"2020":152,"2021":153,"2022":154},{"issue":2493,"volume":2494},{"VOID":2082},{"VOID":306},{"total":19,"publishYear":308,"statisticByYear":2496},{},"2020-12-01","2026-07-23T10:06:42.660+00:00",[55,76],[2501,2505,2509,2513,2517,2521,2525,2529,2533,2537,2541,2545,2549],{"id":18,"text":2502,"url":18,"identifiers":2503},"Rutten M, Ciet P, van den Biggelaar R, et al. Severe tracheal and bronchial collapse in adults with type II mucopolysaccharidosis. Orphanet J Rare Dis. 2016;11:50. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13023-016-%200425-z.",{"doi":2504},"10.1186\u002Fs13023-016- 0425-z",{"id":18,"text":2506,"url":18,"identifiers":2507},"Scarpa M, Almássy Z, Beck M, Bodamer O, Bruce IA, De Meirleir L, et al. Mucopolysaccharidosis type II: European recommendations for the diagnosis and multidisciplinary management of a rare disease. Orphanet J Rare Dis. 2011;6:72. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1750-1172-6-72.",{"doi":2508},"10.1186\u002F1750-1172-6-72",{"id":18,"text":2510,"url":18,"identifiers":2511},"Jones SA, Almássy Z, Beck M, et al. Mortality and cause of death in mucopolysaccharidosis type II-a historical review based on data from the hunter outcome survey (HOS). J Inherit Metab Dis. 2009;32:534–43.",{"doi":2512},"10.1007\u002Fs10545-009-1119-7",{"id":18,"text":2514,"url":18,"identifiers":2515},"Lin HY, Chuang CK, Huang YH, et al. Causes of death and clinical characteristics of 34 patients with Mucopolysaccaridosis II in Taiwan fraom 1995-2012. Orphanet Journal of rare Disease. 2016;11:85. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13023-016-0471-6.",{"doi":2516},"10.1186\u002Fs13023-016-0471-6",{"id":18,"text":2518,"url":18,"identifiers":2519},"Lin SP, Shih SC, Chuang CK, et al. Characterization of pulmonary function impairments in patients with mucopolysaccharidoses–changes with age and treatment. Pediatr Pulmonol. 2014;49:277–84.",{"doi":2520},"10.1002\u002Fppul.22774",{"id":18,"text":2522,"url":18,"identifiers":2523},"Concolino D, Deodato F, Parini R. Enzyme replacement therapy: efficacy and limitations. Ital J Pediatr. 2018;44:117–26.",{"doi":2524},"10.1186\u002Fs13052-018-0562-1",{"id":18,"text":2526,"url":18,"identifiers":2527},"Berger KI, Fagondes SC, Giugliani R, et al. Respiratory and sleep disorders in mucopolysaccharidosis. J Inherit Metab Dis. 2013;36:201–10.",{"doi":2528},"10.1007\u002Fs10545-012-9555-1",{"id":18,"text":2530,"url":18,"identifiers":2531},"Cheng G, Chang FJ, Wang Y, et al. Factors Influencing Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Heart Disease: A Clinical Trial Based on 1-Year Follow-Up. Med Sci Monit. 2019;25:240–7.",{"doi":2532},"10.12659\u002FMSM.908692",{"id":18,"text":2534,"url":18,"identifiers":2535},"Megens JH, de Wit M, van Hasselt PM, et al. Perioperative complications in patients diagnosed with mucopolysaccharidosis and the impact of enzyme replacement therapy followed by hematopoietic stem cell transplantation at early age. Paediatr Anaesth. 2014;24:521–7.",{"doi":2536},"10.1111\u002Fpan.12370",{"id":18,"text":2538,"url":18,"identifiers":2539},"Walker R, Belani KG, Braulin EA, et al. Anaesthesia and airway management in mucopolysccharidosis. J Inherit Metab Dis. 2013;36:211–9.",{"doi":2540},"10.1007\u002Fs10545-012-9563-1",{"id":18,"text":2542,"url":18,"identifiers":2543},"Karl R, Carola S, Regina E, Thomas N, Huber RM. Tracheobronchial stents in mucopolysaccharidosis. Int J Pediatr Otorhinolaryngol. 2016;83:187–92.",{"doi":2544},"10.1016\u002Fj.ijporl.2016.02.015",{"id":18,"text":2546,"url":18,"identifiers":2547},"Kampmann C, Wiethoff CM, Huth RG, et al. Management of life-threatening tracheal stenosis and tracheomalacia in patients with mucopolysaccharidoses. J Inherit Metab Dis Rep. 2017;33:33–9. https:\u002F\u002Fdoi.org\u002F10.1007\u002F8904_2016_578.",{"doi":2548},"10.1007\u002F8904_2016_578",{"id":18,"text":2550,"url":18,"identifiers":2551},"Kamin W. Diagnosis and management of respiratory involvement in hunter syndrome. Acta Paediatr. 2008;97:57–60.",{"doi":2552},"10.1111\u002Fj.1651-2227.2008.00650.x"]