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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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prevalence of radiological lesions of the manubriosternal joint was assessed in 151 patients with chronic inflammatory back pain and in 31 controls with non-inflammatory back pain. Nineteen out of these 151 patients and none of the controls showed unequivocal lesions of the manubriosternal joint without accompanying radiological lesions of the sacroiliac joints or the lumbar spine. Thoracic pain and stiffness were present in 7 out of the 19 patients and in 3 out of the 31 controls (P\u003C0.05); peripheral enthesopathy was present in 10 out of the 19 patients and in 4 out of the 31 controls (P\u003C0.01); none of the patients or controls had rheumatoid factor, subcutaneous nodules, or peripheral arthritis. The suggestion of a “manubriosternal joint syndrome” is warranted by these findings.",{"EN":1038},"Isolated lesions of the manubriosternal joint in patients with inflammatory back pain and negative sacroiliac and spinal radiographs",{"VOID":1040},"Cruickshank B (1956) Lesions of cartilaginous joints in ankylosing spondylitis. J Pathol 71:73–83\nBall J (1971) Enthesopathy of rheumatoid and ankylosing spondylitis. Ann Rheum Dis 30:213–223\nAshley GT (1954) The morphological and pathological significance of synostosis at the manubriosternal joint. Thorax 9:159–166\nAndroic S, Dürrigl Th, Kriz L (1966) Veränderungen an der manubriosternalen Synchondrose bei Spondylitis ankylopoietica. Z Rheumatol 25:314–323\nFrancon F, Faidherbe P, Du Lac G, Leblanc G (1953) Le comportement de l'articulation manubriosternale dans la spondylarthrite ankylosante. Presse Med 61:109–111\nSolovay J, Gardner C (1951) Involvement of the manubriosternal joint in Marie-Strümpell disease. AJR 65:749–759\nSavill DL (1951) The manubriosternal joint in ankylosing spondylitis. J Bone Joint Surg [Br] 33:56–64\nFallet GH (1975) The significance of manubriosternal arthritis and of isolated bilateral sacroiliitis in the early diagnosis of ankylosing spondylitis. In: Wagenhäuser FJ (ed) Chronic forms of polyarthritis. Huber, Bern, pp 105–110\nGrosbois B, Pawlostsky G, Chalès G, Meadeb J, Carsin M, Louboutin J (1981) Etude clinique et radiologique de l'articulation manubriosternale. Rev Rhum Mal Osteoartic 48:495–503\nGoei The HS, Lemmens AJ, Goedhart G, Lokkerbol H, Rahmy A, Steven MM, Linden S van der, Cats A (1985) Radiological and scintigraphic findings in patients with a clinical history of chronic inflammatory back pain. Skeletal Radiol 14:243–248\nSebes JI, Salazar JE (1983) The manubriosternal joint in rheumatoid disease. Am J Rheum 140:117–121\nKhong TK, Rooney PJ (1982) Manubriosternal joint subluxation in rheumatoid arthritis. J Rheumatol 9:712–715\nCalin A, Porta J, Fries JF, Schurman DJ (1977) Clinical history as a screening test for ankylosing spondylitis. JAMA 237:2613–2614\nNiepel GA, Sit'aj S (1973) Enthesopathy. Clin Rheum Dis 5:857–872\nMoll JHM, Wright V (1973) New York clinical criteria for ankylosing spondylitis. A statistical evaluation. Ann Rheum Dis 32:354–363\nKellgren JH, Jeffrey MR, Ball J (1963) The epidemiology of chronic rheumatism, vol I. Blackwell, Oxford, pp 326–327\nBennet PH, Burch TN (1968) Population studies of the rheumatic diseases. Excerpta Medica, Amsterdam, pp 456–457\nLinden SJ van der, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27:361–368\nKhan MA, Linden SM van der, Kushner I, Valkenburg HA, Cats A (1985) Spondylitic disease without radiologic evidence of sacroiliitis in relatives of HLA-B27 positive ankylosing spondylitis patients. Arthritis Rheum 28:40–44\nRosenberg AM, Petty REA (1982) A syndrome of seronegative enthesopathy and arthropathy in children. Arthritis Rheum 25:1041–1047\nRomunde LKJ van, Cats A, Hermans J, Valkenburg HA, Vries E de (1984) Psoriasis and arthritis III. A cross-sectional comparative study of patients with “psoriatic arthritis” and seronegative and seropositive polyarthritis: radiological and HLA aspects. Rheumatol Int 4:67–73\nDekker-Saeys BJ, Meuwissen SGM, Berg-Loonen EM van den, Haas WHD de, Agenant D, Tytgat GNJ (1978) Ankylosing spondylitis and inflammatory bowel disease II. Ann Rheum Dis 37:33–35",{"VOID":1042},"10.1007\u002FBF00541314","PUBLICATION","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00541314",[1047,1063,1078],{"id":1048,"sortIndex":32,"researcher":28,"roles":1049,"affiliations":1051,"properties":1060,"displayName":1062,"givenName":28,"familyName":28},"27690960-08af-477d-9016-dfb4ad06f032",[1050],"AUTHOR",[1052],{"id":1053,"sortIndex":32,"affiliation":1054,"properties":28},"4325b722-a1c6-43a6-832a-5a2d6ad5afcf",{"id":1053,"createTime":28,"updateTime":28,"relativeEntities":1055,"slug":28,"properties":1056,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1059,"statistic":28},[],{"title":1057},{"VI":1058},"Department of Rheumatology, De Wever Ziekenhuis, Heerlen, The Netherlands",[],{"title":1061},{"VI":1062},"H. S. Goei The",{"id":1064,"sortIndex":40,"researcher":28,"roles":1065,"affiliations":1066,"properties":1075,"displayName":1077,"givenName":28,"familyName":28},"8c5c662e-f826-4524-9e91-bcc0f53b2a10",[1050],[1067],{"id":1068,"sortIndex":32,"affiliation":1069,"properties":28},"ce9ce535-1ec6-4476-b0df-b94356d049d6",{"id":1068,"createTime":28,"updateTime":28,"relativeEntities":1070,"slug":28,"properties":1071,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1074,"statistic":28},[],{"title":1072},{"VI":1073},"Department of Rheumatology, University Hospital, Leiden, The Netherlands",[],{"title":1076},{"VI":1077},"A. Cats",{"id":1079,"sortIndex":123,"researcher":28,"roles":1080,"affiliations":1081,"properties":1088,"displayName":1090,"givenName":28,"familyName":28},"dfc5d4bf-18ed-4a63-98f2-afa504c8eb38",[1050],[1082],{"id":1068,"sortIndex":32,"affiliation":1083,"properties":28},{"id":1068,"createTime":28,"updateTime":28,"relativeEntities":1084,"slug":28,"properties":1085,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1087,"statistic":28},[],{"title":1086},{"VI":1073},[],{"title":1089},{"VI":1090},"S. van der Linden","ARTICLE",{"url":1045,"publisher":1093,"properties":1142},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1094,"slug":872,"properties":1095,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1098,"manageAffiliations":1111,"indexDatabases":1122,"url":28,"thumbnailPath":28,"statistic":1137,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"issn":1096,"title":1097},{"VOID":875},{"EN":877},[1099,1103,1107],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":1100,"label":1101,"description":1102,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1104,"label":1105,"description":1106,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1108,"label":1109,"description":1110,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[1112,1117],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":1113,"slug":28,"properties":1114,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1116,"statistic":28},[],{"title":1115},{"EN":904},[906],{"id":908,"createTime":28,"updateTime":28,"relativeEntities":1118,"slug":28,"properties":1119,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1121,"statistic":28},[],{"title":1120},{"EN":912},[906],[1123,1130],{"id":916,"indexDatabase":1124,"url":922,"indexYears":923,"academicFieldIds":1129,"indexDatabaseRanking":928},{"id":792,"createTime":28,"updateTime":28,"relativeEntities":1125,"label":1126,"description":1127,"key":798,"publicationTags":1128,"standard":28},[],{"EN":795,"VI":795},{"EN":795,"VI":797},[800],[925,926,927],{"id":930,"indexDatabase":1131,"url":942,"indexYears":28,"academicFieldIds":1136,"indexDatabaseRanking":28},{"id":932,"createTime":28,"updateTime":28,"relativeEntities":1132,"label":1133,"description":1134,"key":939,"publicationTags":1135,"standard":28},[],{"EN":935,"VI":935},{"EN":937,"VI":938},[941,785],[944],{"impactFactor":32,"impactFactorByYear":1138,"i10Index":948,"i10IndexLast5Year":516,"totalPublication":949,"totalPublicationByYear":1139,"totalCitation":964,"totalCitationByYear":1140,"totalCitationPerPublication":373,"totalCitationPerPublicationByYear":1141,"hindexLast5Year":328,"hindex":328},{"2012":113,"2013":222,"2014":119,"2015":696,"2016":422,"2017":582,"2018":320,"2019":224,"2020":222,"2021":228,"2022":947,"2023":338},{"1981":51,"1982":140,"1983":132,"1984":142,"1985":133,"1986":150,"1987":352,"1988":133,"1989":352,"1990":142,"1991":202,"1992":141,"1993":69,"1994":142,"1995":138,"1996":133,"1997":136,"1998":134,"1999":69,"2000":133,"2001":208,"2002":436,"2003":951,"2004":952,"2005":953,"2006":362,"2007":529,"2008":954,"2009":459,"2010":607,"2011":955,"2012":956,"2013":957,"2014":578,"2015":958,"2016":837,"2017":959,"2018":960,"2019":961,"2020":605,"2021":962,"2022":963,"2023":211,"2024":145},{"1981":155,"1982":829,"1983":966,"1984":142,"1985":140,"1986":207,"1987":967,"1988":968,"1989":332,"1990":969,"1991":141,"1992":834,"1993":970,"1994":971,"1995":149,"1996":161,"1997":560,"1998":972,"1999":973,"2000":968,"2001":959,"2002":974,"2003":975,"2004":976,"2005":977,"2006":978,"2007":979,"2008":980,"2009":981,"2010":982,"2011":983,"2012":984,"2013":985,"2014":986,"2015":987,"2016":988,"2017":989,"2018":990,"2019":991,"2020":992,"2021":993,"2022":210},{"1981":376,"1982":995,"1983":996,"1984":40,"1985":997,"1986":705,"1987":998,"1988":999,"1989":343,"1990":1000,"1991":741,"1992":1001,"1993":1002,"1994":579,"1995":1003,"1996":186,"1997":1004,"1998":1005,"1999":1006,"2000":999,"2001":1007,"2002":1008,"2003":1009,"2004":1010,"2005":1011,"2006":1012,"2007":1013,"2008":1014,"2009":1015,"2010":1015,"2011":1016,"2012":1002,"2013":1017,"2014":587,"2015":1018,"2016":1019,"2017":1020,"2018":442,"2019":1021,"2020":1022,"2021":1023,"2022":288},{"pages":1143,"volume":1145},{"VOID":1144},"245-249",{"VOID":1146},"6","1986-11-01",1986,[928,941],false,{"id":1152,"createTime":1153,"updateTime":1154,"relativeEntities":1155,"slug":1156,"properties":1157,"entityType":1043,"verifyStatus":26,"verifyTime":1154,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1168,"fullTextUrl":28,"authors":1169,"publicationType":1091,"publisherRelationship":1230,"citationCount":28,"citationInfo":28,"publishDate":1280,"publishYear":1281,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1282,"openAccess":28,"references":28,"isForceReanalyzing":1150},"00255a3a-c4b0-419f-9297-0219a70698e9","2024-04-07T15:24:14.374+00:00","2024-12-30T22:42:00.149+00:00",[],"Dyslipoproteinemia-during-the-active-course-of-systemic-lupus-erythematosus-in-association-with-anti-double-stranded-DNA-anti-dsDNA-antibodies",{"abstract":1158,"title":1160,"keywords":1162,"references":1164,"doi":1166},{"EN":1159},"Dyslipoproteinemia is common in lupus patients. In this study, we investigated the pattern of dyslipoproteinemia in the course of active systemic lupus erythematosus (SLE) in possible association with anti-double-stranded DNA (anti-dsDNA) antibodies. Forty-six lupus patients under 45 years old who fulfilled the American College of Rheumatology revised criteria for the classification of SLE were selected. The exclusion criteria were renal failure, nephrotic syndrome, thyroid or liver disease, diabetes mellitus, obesity, pregnancy and taking drugs that induce dyslipidemia. Disease activity was measured by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Comparison of the lipid profiles, between active and inactive groups determined high levels of serum TG and VLDL and low levels of serum HDL in active group in comparison with inactive group(P \u003C 0.05). The results indicated that the levels of TG and VLDL were significantly elevated in the patients with positive anti-dsDNA (P \u003C 0.05). Although, the mean of serum HDL levels was also lower in patients with positive anti-dsDNA, the difference was not significant. This pattern of dyslipoproteinemia in active SLE may be associated with the autoimmune mechanisms especially in relation to the presence of anti-dsDNA antibodies.",{"EN":1161},"Dyslipoproteinemia during the active course of systemic lupus erythematosus in association with anti-double-stranded DNA (anti-dsDNA) antibodies",{"EN":1163},"",{"VOID":1165},"Formiga F, Meco JF, Pinto X, Jacob J, Moga I, Pujol R (2001) Lipid and lipoprotein levels in premenopausal systemic lupus erythematosus patients. Lupus 10:359–363\nEttinger WH, Goldberg AP, Appelbaum-Bowden D, Hazzard WR (1987) Dyslipoproteinemia in systemic lupus erythematosus. Effect of corticosteroids. Am J Med 83:503–508\nPetri M (2000) Detection of coronary artery disease and role of traditional risk factors in the Hopkins lupus Cohort. Lupus 9(3):170–175\nLeong KH, Koh ET, Feng PH, Boey ML (1994) Lipid profiles in patients with systemic lupus erythematosus. J Rheumatol 21:1264–1267\nLahita RG, Rivkin E, Cavanagh I, Romano P (1993) Low levels of total cholesterol, high-density lipoprotein, and apolipoprotein A1 in association with anticardiolipin antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 36:1566–1574\nIlowite NT, Samuel P, Ginzler E, Jacobson MS (1988) Dyslipoproteinemia in pediatric systemic lupus erythematosus. Arthritis Rheum 31:859–863\nBorba EF, Bonfá E (1997) Dyslipoproteinemias in systemic lupus erythematosus: influence of disease, activity, and anticardiolipin antibodies. Lupus 6:533–539\nReichlin M, Fesmire J, Quintero-Del-Rio AI, Wolfson-Reichlin M (2002) Autoantibodies to lipoprotein lipase and dyslipidemia in systemic lupus erythematosus. Arthritis Rheum 46:2957–2963\nTan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277\nBombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH (1992) Committee on prognosis studies in SLE. Derivation of the SLEDAI a: disease activity index for lupus patients. Arthritis Rheum 35:630–640\nWarnick GR, Benderson J, Albers JJ (1982) Dextran sulfate–Mg2 + precipitation procedure for quantitation of high-density lipoprotein cholesterol. Clin Chem 28:1379–1388\nFriedewald WT, Levy RI, Fredrickson DS (1972) Estimation of concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin chem 18:499–502\nGharavi AV, Lockshin MD (1997) Antiphospholipid antibodies. In: Rose NR, Macario EC, Folds JD, et al (eds) manual of clinical laboratory, 5th edn, ASM press Immunology, Washington DC, pp 949–953\nSvenungsson E, Gunnarsson I, Fei GZ, Lundberg IE, Klareskog L, Frostegard J (2003) Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha\u002F tumor necrosis factor receptor system in systemic lupus erythematosus. Arthritis Rheum 48:2533–2540\nIlowite NT, Copperman N, Leicht T, Kwong T, Jacobson MS (1995) Effects of dietary modification and fish oil supplementation on dyslipoproteinemia in pediatric systemic lupus erythematosus. J Rheumatol 22:1347–1351\nGinsberg HN (1990) Lipoprotein physiology and its relationship to atherogenesis. Endocrinol Metab Clin North Am 19:211–228\nBorba EF, Bonfa E, Vinagre CG, Ramires JA, Maranhao RC. Chylomicron (2000) Metabolism is markedly altered in systemic lupus erythematosus. Arthritis Rheum 43:1033–1040\nBeaumont JL, Berard M, Antonucci M, Delplanque B, Vranckx R (1997) Inhibition of lipoprotein lipase activity by a monoclonal immunoglobulin in autoimmune hyperlipidemia. Atherosclerosis 26:67–77\nAlverson DC, Chase HP (1977) Systemic lupus erythematosus in childhood presenting as hyperlipoproteinemia. J Pediatr 91:72–75\nDelgado Alves J, Ames PR, Donohue S, Stanyer L, Nourooz-Zadeh J, Ravirajan C, Isenberg DA (2002) Antibodies to high-density lipoprotein and beta2-glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome. Arthritis Rheum 46:2686–2694\nAbe H, Tsuboi N, Suzuki S, Sakuraba H, Takanashi H, Tahara K,Tonozuka N,Hayashi T, Umeda M (2001) Anti- apolipoprotein A-I autoantibody: characterization of monoclonal autoantibodies from patients with systemic lupus erythematosus. J Rheumatol 28:990–995\nDinu AR, Merrill JT, Shen C, Antonov IV, Myones BL, Lahita RG (1998) Frequency of antibodies to the cholesterol transport protein apolipoprotein A1 in patients with SLE. Lupus 7:355–360\nLazarevic MB, Vitic J, Myones BL, Mladenovic V, Nanusevic N, Skosey JL, Swedler WI (1993) Antilipoprotein antibodies in rheumatoid arthritis. Semin Arthritis Rheum 22:385–391\nDavas EM, Tsirogianni A, Kappou I, Karamitsos D, Economidou I, Dantis PC (1999) Serum IL-6, TNFα, p55 srTNFα, p75 srTNFα, srIL-2α levels and disease activity in systemic lupus erythematosus. Clin Rheumatol 18:17–22\nSemb H, Peterson J, Tavernier J, Olivecrona T (1987) Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo. J Biol chem 262:8390–8394\nBeutler BA, Cerami A (1985) Recombinant interleukin-1 suppresses lipoprotein lipase activity in 3T3-L1 cells. J Immunol 135:3969–3971\nEhnholm C, Aho K, Huttunen JK, Kostiainen E, Mattila K, Pakkarainen J, Cantell K (1982) Effect of interferon on plasma lipoproteins and on the activity of postheparin plasma lipases. Arteriosclerosis 2:68–73\nKwiterovich PO Jr (1998) The antiatherogenic role of high-density lipoprotein cholesterol. Am J Cardiol 82:13Q–21Q\nThird report of the National Cholesterol Education Program (NCEP) (2002) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III): final report. Circulation 106:3143–3420",{"VOID":1167},"10.1007\u002Fs00296-006-0195-3","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00296-006-0195-3",[1170,1185,1200,1215],{"id":1171,"sortIndex":32,"researcher":28,"roles":1172,"affiliations":1173,"properties":1182,"displayName":1184,"givenName":28,"familyName":28},"74be20de-7e02-4dbc-ad64-1180521bc540",[1050],[1174],{"id":1175,"sortIndex":32,"affiliation":1176,"properties":28},"a354ee5b-8d67-475e-887f-5ac28759b3e8",{"id":1175,"createTime":28,"updateTime":28,"relativeEntities":1177,"slug":28,"properties":1178,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1181,"statistic":28},[],{"title":1179},{"VI":1180},"Department of Pediatrics, Division of Immunology and Allergy, Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran",[],{"title":1183},{"VI":1184},"Sara 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objective was to compare patients with concurrent and sequentially presented systemic lupus erythematosus (SLE)-related protein-losing enteropathy (PLE). Patients with history of SLE admitted for PLE were selected and their clinical, laboratory, endoscopic and imaging characteristics, treatment and outcome were analyzed. From 2001 to 2010, 21 and 27 patients had concurrent and sequentially presented SLE-related PLE, respectively, and their clinical characteristics were comparable except the following: the concurrent group had more pleural effusion (P \u003C 0.01), cutaneous (P \u003C 0.03), neurological (P = 0.02) manifestations, higher creatine phosphokinase (127.6 IU\u002FL vs. 105.7 IU\u002FL, P \u003C 0.05) and lactate dehydrogenase (504.0 IU\u002FL vs. 422.2 IU\u002FL, P \u003C 0.05); whereas the sequential group had higher anti-double strand DNA titer (179.8 vs. 100.4, P \u003C 0.05), 24-h urine protein excretion (1.1 g\u002Fd vs. 0.6 g\u002Fd, P \u003C 0.05) and increased proteinuria after onset of PLE (0.21 g\u002Fd vs. 1.1 g\u002Fd, P \u003C 0.04). The endoscopic, histological and radiological features were comparable between the two groups. More patients from the sequential group required more potent immunosuppressive therapy for induction (55.6% vs. 14.3%, P = 0.002) and maintenance (48.2% vs. 9.5%, P \u003C 0.01).The concurrent group associated with better treatment outcomes, with requiring shorter mean time (4.5 months vs. 7.9 months, P = 0.03) for normalbuminemia and more individuals (90.5% vs. 63%, P \u003C 0.02) achieving normalbuminemia in first year. The complications were infrequent: two drug-related adverse events from each group, one patient each from the concurrent group developed shingle and SLE nephropathy. PLE associated with concurrent and sequentially presented of SLE are comparable in clinical behavior; and the immunosuppressive therapy is generally well-responded and tolerated. However, the concurrent group is associated with better disease activity control.",{"EN":1291},"Clinical characteristics of concurrent and sequentially presented lupus-related protein-losing enteropathy: What are their differences?",{"VOID":1293},"Aoki T, Noma N, Takajo I et al (2002) Protein-losing gastropathy associated with autoimmune disease: successful treatment with prednisolone. J Gastroenterol 37(3):204–9 (Review)\nMok CC, Ying KY, Mak A et al (2006) Outcome of protein-losing gastroenteropathy in systemic lupus erythematosus treated with prednisolone and azathioprine. Rheumatol (Oxford). 45(4):425–9. [Epub 2005 Oct 18]\nHsu YJ, Lin SH, Lin YF et al (2009) Pitfalls of technetium-99 m-labeled human serum albumin scintigraphy for protein-losing enteropathy. Kidney Int 76(8):911; author reply 911–2\nChen YC, Hwang SJ, Chiu JS et al (2009) Chronic edema from protein-losing enteropathy: scintigraphic diagnosis. Kidney Int 75(10):1124\nTan EM, Cohen AS, Fries JF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthr Rheum 25:1271–1277\nGladman DD, Goldsmith CH, Urowitz MB et al (1994) Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation. J Rheumatol 21:1468–1471\nAl-Mogairen SM (2011) Lupus protein-losing enteropathy (LUPLE): a systematic review. Rheumatol Int 31(8):995–1001. [Epub 2011 Feb 23]\nZheng WJ, Tian XP, Li L, Jing HL et al (2007) Protein-losing enteropathy in systemic lupus erythematosus: analysis of the clinical features of fifteen patients. J Clin Rheumatol 13(6):313–316\nZhu LM, Sun G, Qian JM et al (2011) A clinical analysis of 61 cases of protein-losing enteropathy. Zhonghua Nei Ke Za Zhi 50(3):209–11 (Chinese)\nChau TN, Mok MY, Chan EY et al (2011) Evaluation of Performance of Measurement of Fecal α (1)-Antitrypsin Clearance and technetium-99 m Human Serum Albumin Scintigraphy in Protein-Losing Enteropathy. Digestion 84(3):199–206. [Epub ahead of print]\nWood ML, Foulds IS, French MA (1984) Protein losing enteropathy due to systemic lupus erythematosus. Gut 25(9):1013–1015\nItoi K, Sasaki T, Sawai T et al (1989) Protein-losing gastroenteropathy in association with immune deposits in gastrointestinal mucosal capillaries. Am J Gastroenterol 84(2):187–191\nWeiser MM, Andres GA, Brentjens JR et al (1981) Systemic lupus erythematosus and intestinal venulitis. Gastroenterology 81(3):570–579\nGornisiewicz M, Rodriguez M, Smith JK et al (2001) Protein-losing enteropathy in a young African-American woman with abdominal pain, diarrhea and hydronephrosis. Lupus 10(12):835–840\nPerednia DA, Curosh NA (1990) Lupus-associated protein-losing enteropathy. Arch Intern Med 150(9):1806–10 (Review)\nMarks J, Birkett DA, Shuster S (1972) “Capillary permeability” in patients with collagen vascular diseases. Br Med J 1(5803):782–784\nTsutsumi A, Sugiyama T, Matsumura R et al (1991) Protein losing enteropathy associated with collagen diseases. Ann Rheum Dis 50(3):178–81 (Review)\nFresko I, Hamuryudan V, Demir M et al (2001) Intestinal permeability in Behçet’s syndrome. Ann Rheum Dis 60(1):65–66\nMullin JM, Snock KV (1990) Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res 50(7):2172–2176\nYazici Y, Erkan D, Levine DM et al (2002) Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology. Lupus 11(2):119–23 (Review)",{"VOID":1295},"10.1007\u002Fs00296-011-2356-2","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00296-011-2356-2",[1298,1313,1328],{"id":1299,"sortIndex":32,"researcher":28,"roles":1300,"affiliations":1301,"properties":1310,"displayName":1312,"givenName":28,"familyName":28},"145ab9ce-88fa-45f0-a8e2-eef5ac2ebb6e",[1050],[1302],{"id":1303,"sortIndex":32,"affiliation":1304,"properties":28},"1fb0316c-0521-4f77-bf41-e4ad375c224e",{"id":1303,"createTime":28,"updateTime":28,"relativeEntities":1305,"slug":28,"properties":1306,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1309,"statistic":28},[],{"title":1307},{"VI":1308},"Department of Medicine and Geriatrics, Tuen Mun Hospital, Tuen Mun, Hong Kong",[],{"title":1311},{"VI":1312},"Siu-tong 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Mediterranean fever (FMF) is the most frequent hereditary inflammatory disease characterized by self-limited recurrent attacks of fever and serositis. It is transmitted in an autosomal recessive pattern and affects certain ethnic groups mainly Jews, Turks, Arabs, and Armenians. FMF is caused by mutations in MEFV gene, which encodes pyrin. This protein is expressed mainly in myeloid\u002Fmonocytic cells and modulates IL-1β processing, NF-κB activation, and apoptosis. A mutated pyrin probably results in uncontrolled inflammation. The most devastating complication of FMF is amyloidosis, leading to chronic renal failure. M694V homozygocity, male gender and the α\u002Fα genotype of serum amyloid A1 gene are the currently established risk factors for development of amyloidosis. Daily colchicine is the mainstay of the therapy for the disease, resulting in complete remission or marked reduction in the frequency and duration of attacks in most patients. It is also effective in preventing and arresting renal amyloidosis.",{"EN":1409},"Familial Mediterranean fever",{"VOID":1411},"Sohar E, Gafni J, Pras M, Heller H (1967) Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med 43:227–253\nAncient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever (1997) The international FMF consortium. Cell 90:797–807\nA candidate gene for familial Mediterranean fever (1997) The French FMF consortium. Nat Genet 17:25–31\nYilmaz E, Ozen S, Balci B, Duzova A, Topaloglu R, Besbas N, Saatci U, Bakkaloglu A, Ozguc M (2001) Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. 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Medicine (Baltimore) 73:133–144\nDrenth JP, Cuisset L, Grateau G, Vasseur C, van de Velde-Visser SD, de Jong JG, Beckmann JS, van der Meer JW, Delpech M (1999) Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group. Nat Genet 22:178–181\nMuckle TJ, Wellsm (1962) Urticaria, deafness, and amyloidosis: a new heredo-familial syndrome. Q J Med 31:235–248\nPrieur AM, Griscelli C, Lampert F, Truckenbrodt H, Guggenheim MA, Lovell DJ, Pelkonnen P, Chevrant-Breton J, Ansell BM (1987) A chronic, infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients. Scand J Rheumatol Suppl 66:57–68\nPadeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P, Migdal A, Pras M, Passwell JH (1999) Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 135:98–101\nGoldfinger SE (1972) Colchicine for familial Mediterranean fever. N Engl J Med 287:1302\nZemer D, Revach M, Pras M, Modan B, Schor S, Sohar E, Gafni J (1974) A controlled trial of colchicine in preventing attacks of familial Mediterranean fever. N Engl J Med 291:932–934\nLivneh A, Zemer D, Langevitz P, Laor A, Sohar E, Pras M (1994) Colchicine treatment of AA amyloidosis of familial Mediterranean fever. An analysis of factors affecting outcome. Arthritis Rheum 37:1804–1811\nZemer D, Pras M, Sohar E, Modan M, Cabili S, Gafni J (1986) Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med 314:1001–1005\nLidar M, Scherrmann JM, Shinar Y, Chetrit A, Niel E, Gershoni-Baruch R, Langevitz P, Livneh A (2004) Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization. Semin Arthritis Rheum 33:273–282\nLidar M, Kedem R, Langevitz P, Pras M, Livneh A (2003) Intravenous colchicine for treatment of patients with familial Mediterranean fever unresponsive to oral colchicine. J Rheumatol 30:2620–2623\nBen-Chetrit E, Levy M (1998) Colchicine: 1998 update. Semin Arthritis Rheum 28:48–59\nAmital H, Ben-Chetrit E (2004) Therapeutic approaches to familial Mediterranean fever. What do we know and where are we going to? Clin Exp Rheumatol 22:S4–S7\nOzkaya N, Yalcinkaya F (2003) Colchicine treatment in children with familial Mediterranean fever. Clin Rheumatol 22:314–317\nTunca M, Tankurt E, Akbaylar Akpinar H, Akar S, Hizli N, Gonen O (1997) The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study. Br J Rheumatol 36:1005–1008\nTunca M, Akar S, Soyturk M, Kirkali G, Resmi H, Akhunlar H, Gonen O, Gallimore JR, Hawkins PN, Tankurt E (2004) The effect of interferon alpha administration on acute attacks of familial Mediterranean fever: a double-blind, placebo-controlled trial. Clin Exp Rheumatol 22:S37–S40\nCalguneri M, Apras S, Ozbalkan Z, Ozturk MA (2004) The efficacy of interferon-alpha in a patient with resistant familial Mediterranean fever complicated by polyarteritis nodosa. Intern Med 43:612–614\nSeyahi E, Ozdogan H, Masatlioglu S, Yazici H (2002) Successful treatment of familial Mediterranean fever attacks with thalidomide in a colchicine resistant patient. Clin Exp Rheumatol 20:S43–S44\nDrenth JP, Vonk AG, Simon A, Powell R, van der Meer JW (2001) Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial. J Pharmacol Exp Ther 298:1221–1226\nSampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G (1991) Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 173:699–703\nMilledge J, Shaw PJ, Mansour A, Williamson S, Bennetts B, Roscioli T, Curtin J, Christodoulou J (2002) Allogeneic bone marrow transplantation: cure for familial Mediterranean fever. Blood 100:774–777\nTouitou I, Ben-Chetrit E, Gershoni-Baruch R, Grateau G, Kastner DL, Kone-Paut I, Livneh A, Manna R, Mansour I, Ozdogan H, Ozen S, Sarkisian T, Tunca M, Yalcinkaya F (2003) Allogenic bone marrow transplantation: not a treatment yet for familial Mediterranean fever. Blood 102:409\nKeven K, Sengul S, Kutlay S, Ekmekci Y, Anadol E, Nergizoglu G, Ates K, Erturk S, Erbay B (2004) Long-term outcome of renal transplantation in patients with familial Mediterranean fever amyloidosis: a single-center experience. Transplant Proc 36:2632–2634\nAltiparmak MR, Pamuk ON, Ataman R, Serdengecti K (2004) Continuous ambulatory peritoneal dialysis in familial Mediterranean fever amyloidosis patients with end-stage renal failure: a single-centre experience from Turkey. Nephron Clin Pract 98:c119–c123\nRawashdeh MO, Majeed HA (1996) Familial Mediterranean fever in Arab children: the high prevalence and gene frequency. Eur J Pediatr 155:540–544",{"VOID":1413},"10.1007\u002Fs00296-005-0074-3","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00296-005-0074-3",[1416],{"id":1417,"sortIndex":32,"researcher":28,"roles":1418,"affiliations":1419,"properties":1428,"displayName":1430,"givenName":28,"familyName":28},"5150e062-e9f2-41a3-9eb9-b7f3f60e2e5e",[1050],[1420],{"id":1421,"sortIndex":32,"affiliation":1422,"properties":28},"5a5e998c-f3a2-4ba0-b82e-40ffb4106d77",{"id":1421,"createTime":28,"updateTime":28,"relativeEntities":1423,"slug":28,"properties":1424,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1427,"statistic":28},[],{"title":1425},{"VI":1426},"Division of Immunology and Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Balcova-Izmir, Turkey",[],{"title":1429},{"VI":1430},"Fatos Onen",{"url":1414,"publisher":1432,"properties":1481},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1433,"slug":872,"properties":1434,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1437,"manageAffiliations":1450,"indexDatabases":1461,"url":28,"thumbnailPath":28,"statistic":1476,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"issn":1435,"title":1436},{"VOID":875},{"EN":877},[1438,1442,1446],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":1439,"label":1440,"description":1441,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1443,"label":1444,"description":1445,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1447,"label":1448,"description":1449,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[1451,1456],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":1452,"slug":28,"properties":1453,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1455,"statistic":28},[],{"title":1454},{"EN":904},[906],{"id":908,"createTime":28,"updateTime":28,"relativeEntities":1457,"slug":28,"properties":1458,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1460,"statistic":28},[],{"title":1459},{"EN":912},[906],[1462,1469],{"id":916,"indexDatabase":1463,"url":922,"indexYears":923,"academicFieldIds":1468,"indexDatabaseRanking":928},{"id":792,"createTime":28,"updateTime":28,"relativeEntities":1464,"label":1465,"description":1466,"key":798,"publicationTags":1467,"standard":28},[],{"EN":795,"VI":795},{"EN":795,"VI":797},[800],[925,926,927],{"id":930,"indexDatabase":1470,"url":942,"indexYears":28,"academicFieldIds":1475,"indexDatabaseRanking":28},{"id":932,"createTime":28,"updateTime":28,"relativeEntities":1471,"label":1472,"description":1473,"key":939,"publicationTags":1474,"standard":28},[],{"EN":935,"VI":935},{"EN":937,"VI":938},[941,785],[944],{"impactFactor":32,"impactFactorByYear":1477,"i10Index":948,"i10IndexLast5Year":516,"totalPublication":949,"totalPublicationByYear":1478,"totalCitation":964,"totalCitationByYear":1479,"totalCitationPerPublication":373,"totalCitationPerPublicationByYear":1480,"hindexLast5Year":328,"hindex":328},{"2012":113,"2013":222,"2014":119,"2015":696,"2016":422,"2017":582,"2018":320,"2019":224,"2020":222,"2021":228,"2022":947,"2023":338},{"1981":51,"1982":140,"1983":132,"1984":142,"1985":133,"1986":150,"1987":352,"1988":133,"1989":352,"1990":142,"1991":202,"1992":141,"1993":69,"1994":142,"1995":138,"1996":133,"1997":136,"1998":134,"1999":69,"2000":133,"2001":208,"2002":436,"2003":951,"2004":952,"2005":953,"2006":362,"2007":529,"2008":954,"2009":459,"2010":607,"2011":955,"2012":956,"2013":957,"2014":578,"2015":958,"2016":837,"2017":959,"2018":960,"2019":961,"2020":605,"2021":962,"2022":963,"2023":211,"2024":145},{"1981":155,"1982":829,"1983":966,"1984":142,"1985":140,"1986":207,"1987":967,"1988":968,"1989":332,"1990":969,"1991":141,"1992":834,"1993":970,"1994":971,"1995":149,"1996":161,"1997":560,"1998":972,"1999":973,"2000":968,"2001":959,"2002":974,"2003":975,"2004":976,"2005":977,"2006":978,"2007":979,"2008":980,"2009":981,"2010":982,"2011":983,"2012":984,"2013":985,"2014":986,"2015":987,"2016":988,"2017":989,"2018":990,"2019":991,"2020":992,"2021":993,"2022":210},{"1981":376,"1982":995,"1983":996,"1984":40,"1985":997,"1986":705,"1987":998,"1988":999,"1989":343,"1990":1000,"1991":741,"1992":1001,"1993":1002,"1994":579,"1995":1003,"1996":186,"1997":1004,"1998":1005,"1999":1006,"2000":999,"2001":1007,"2002":1008,"2003":1009,"2004":1010,"2005":1011,"2006":1012,"2007":1013,"2008":1014,"2009":1015,"2010":1015,"2011":1016,"2012":1002,"2013":1017,"2014":587,"2015":1018,"2016":1019,"2017":1020,"2018":442,"2019":1021,"2020":1022,"2021":1023,"2022":288},{"pages":1482,"volume":1484},{"VOID":1483},"489-496",{"VOID":1485},"26","2005-11-10",2005,[928,941],{"id":1490,"createTime":1491,"updateTime":1492,"relativeEntities":1493,"slug":1494,"properties":1495,"entityType":1043,"verifyStatus":26,"verifyTime":1492,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1504,"fullTextUrl":28,"authors":1505,"publicationType":1091,"publisherRelationship":1562,"citationCount":28,"citationInfo":28,"publishDate":1617,"publishYear":1618,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1619,"openAccess":28,"references":28,"isForceReanalyzing":1150},"0074de0a-864e-4904-861a-28c54eedc9f4","2024-02-09T17:21:39.798+00:00","2024-12-10T08:01:03.550+00:00",[],"Immunoglobulin-G4-related-disease-mimicking-lymphoma-in-a-Chinese-patient",{"abstract":1496,"title":1498,"references":1500,"doi":1502},{"EN":1497},"Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by multiorgan fibrosis with IgG4-producing plasma cells, increased IgG4 serum concentration, and responsiveness to steroid therapy. IgG4-RD tends to form tumefactive lesions. As a result, patients are often suspected of having a malignancy such as lymphoma. In this article, a patient with IgG4-RD and the deep vein thrombosis who was initially suspected of lymphoma is reported. The 63-year-old man presented with painless salivary swelling and multi-lymphadenopathy, progressively swelling and pain in the left leg. Salivary biopsy showed IgG4+ plasma cells >50 per high-power field and IgG4+\u002FIgG+ plasma cell ratio >40 %. The serum IgG4 level was 4.28 g\u002FL (range 0.03–2.01 mg\u002FdL). Ultrasonography showed that the inferior vena cava was partially occluded, and thrombosis in the left iliac vein. Computed tomography scan revealed plaque-like tissue surrounding the inferior vena cava and abdominal aortic, which is typical for the diagnosis of retroperitoneal fibrosis. The patient was effectively treated with corticosteroids, interventional therapy, and anticoagulant therapy which resulted in a reduction in the swelling of the lymph nodes and left leg. Patient with IgG4-RD and deep vein thrombosis is rare and could be misdiagnosed easily as malignant disease. Accurate diagnosis is critical for disease management.",{"EN":1499},"Immunoglobulin G4-related disease mimicking lymphoma in a Chinese patient",{"VOID":1501},"O’Reilly DA, Malde DJ, Duncan T et al (2014) Review of the diagnosis, classification and management of autoimmune pancreatitis. World J Gastrointest Pathophysiol 5:71–81\nPalazzo E, Palazzo C, Palazzo M (2014) IgG4-related disease. Joint Bone Spine 81:27–31\nNambam B, Winter WE, Schatz DA (2014) IgG4 antibodies in autoimmune polyglandular disease and IgG4-related endocrinopathies: pathophysiology and clinical characteristics. Curr Opin Pediatr 26:493–499\nFerry JA, Deshpande V (2012) IgG4-related disease in the head and neck. Semin Diagn Pathol 29:235–244\nChen H, Lin W, Wang Q et al (2014) IgG4-related disease in a Chinese cohort: a prospective study. Scand J Rheumatol 43:70–74\nDeshpande V, Zen Y, Chan JK et al (2012) Consensus statement on the pathology of IgG4-related disease. Mod Pathol 25:1181–1192\nGeyer JT, Deshpande V (2011) IgG4-associated sialadenitis. Curr Opin Rheumatol 23:95–101\nSato Y, Yoshino T (2012) IgG4-related lymphadenopathy. Int J Rheumatol 2012:572539\nTzou M, Gazeley DJ, Mason PJ (2014) Retroperitoneal fibrosis. Vasc Med 19:407–414\nTanuma Y, Yokoo A (2002) Idiopathic retroperitoneal fibrosis with large vessel thrombosis. Hinyokika Kiyo 48:539–543\nPaetzold S, Gary T, Hafner F et al (2013) Thrombosis of the inferior vena cava related to Ormond’s disease. Clin Rheumatol 32:S67–S70\nKamisawa T, Okazaki K, Kawa S et al (2010) Japanese consensus guidelines for management of autoimmune pancreatitis. III. Treatment and prognosis of AIP. J Gastroenterol 45:471–477",{"VOID":1503},"10.1007\u002Fs00296-015-3259-4","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00296-015-3259-4",[1506,1521,1536,1549],{"id":1507,"sortIndex":32,"researcher":28,"roles":1508,"affiliations":1509,"properties":1518,"displayName":1520,"givenName":28,"familyName":28},"b16ab1d1-9738-4f95-ab09-4c77337cd050",[1050],[1510],{"id":1511,"sortIndex":32,"affiliation":1512,"properties":28},"70610843-1726-489f-bed8-4b652eeb9b63",{"id":1511,"createTime":28,"updateTime":28,"relativeEntities":1513,"slug":28,"properties":1514,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1517,"statistic":28},[],{"title":1515},{"VI":1516},"Department of Hematology, Henan Provincial People’s Hospital, The People’s Hospital of Zhengzhou University, Zhengzhou, China",[],{"title":1519},{"VI":1520},"Yanhui Liu",{"id":1522,"sortIndex":40,"researcher":28,"roles":1523,"affiliations":1524,"properties":1533,"displayName":1535,"givenName":28,"familyName":28},"ed9ff0b2-8fa0-4882-94aa-d3c5d387ebc1",[1050],[1525],{"id":1526,"sortIndex":32,"affiliation":1527,"properties":28},"92711238-a88b-4523-ac66-e1a2777c3138",{"id":1526,"createTime":28,"updateTime":28,"relativeEntities":1528,"slug":28,"properties":1529,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1532,"statistic":28},[],{"title":1530},{"VI":1531},"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People’s Hospital, The People’s Hospital of Zhengzhou University, Zhengzhou, China",[],{"title":1534},{"VI":1535},"Fei 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(FM) is a common disease that results in poor quality of life, causing widespread musculoskeletal pain and stiffness, fatigue, sleep disorders, and cognitive impairment among other symptoms. The lack of an effective treatment makes necessary a multidimensional management. FM patients usually seek, from different sources, information about possible benefits from foods, nutrients, or diets. Our objective was to investigate the dietary awareness, food allergies and\u002For intolerances (FAIs), and nutritional supplement (NS) consumption of FM patients. A questionnaire was prepared with six questions regarding dietary habits, FAIs, and NS use. The questionnaire was filled out by patients recruited in local fibromyalgia associations. One hundred and one women were suffering from FM, diagnosed for more than 6 months, mean age of 53.88 ± 7.78 years; 30% of them changed their diet because of their disease, trying to improve it, and most of them were also using some NS; 7% of women in this group had FAIs, a figure slightly higher than the FAI prevalence in the general population (2–5%) and positively associated with consumption of supplements. Among NS users, some differences were observed; past NS users currently consume a wider range of products, more than new NS users. Magnesium was one of the supplements most recommended specifically for FM. Seventy-four percentage of these patients used NS following advice from health professionals. Once patients are diagnosed, they change their dietary habits and nutritional supplement intake, seeking nutritional strategies to improve their symptoms. Health professionals’ advice plays a relevant role.",{"EN":1630},"Dietary aspects in fibromyalgia patients: results of a survey on food awareness, allergies, and nutritional supplementation",{"VOID":1632},"Salaffi F, Sarzi-Puttini P, Girolimetti R, Atzeni F, Gasparini S, Grassi W (2009) Health-related quality of life in fibromyalgia patients: a comparison with rheumatoid arthritis patients and the general population using the SF-36 health survey. Clin Exp Rheumatol 27(5 Suppl 56):S67–74\nRehm SE, Koroschetz J, Gockel U, Brosz M, Freynhagen R, Tölle TR, Baron R (2010) A cross-sectional survey of 3,035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles. Rheumatol (Oxford) 49(6):1146–1152\nCalande EP, García-Carrillo J, García-Leiva JM, Rico-Villademoros F, Molina-Barea R, Rodríguez-López CM (2010) Subgrouping patients with fibromyalgia according to the results of the fibromyalgia impact questionnaire: a replication study. Rheumatol Int. doi:10.1007\u002Fs00296-010-1521-3\nVerra ML, Angst F, Brioschi R, Lehmann S, Keefe FJ, Staal JB, de Bie RA, Aeschlimann A (2009) Does classification of persons with fibromyalgia into multidimensional pain inventory subgroups detect differences in outcome after a standard chronic pain management program? Pain Res Manag 14(6):445–453\nWilson HD, Starz TW, Robinson JP, Turk DC (2009) Heterogeneity within the fibromyalgia population: theoretical implications of variable tender point severity ratings. J Rheumatol 36(12):2795–2801\nCarville S, Arendt-Nielsen S, Bliddal H et al (2008) EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 67(4):536\nArranz LI, Canela MA, Rafecas M (2010) Fibromyalgia and nutrition, what do we know? Rheumatol Int 30(11):1417–1427\nYunus MB, Arslan S, Aldag JC (2002) Relationship between body mass index and fibromyalgia features. Scand J Rheumatol 31(1):27–31\nNeumann L, Lerner E, Glazer Y, Bolotin A, Shefer A, Buskila D (2008) A cross-sectional study of the relationship between body mass index and clinical characteristics, tenderness measures, quality of life, and physical functioning in fibromyalgia patients. Clin Rheumatol 27(12):1543–1547\nBennett RM, Jones J, Turk DC, Russell IJ, Matallana L (2007) An internet survey of 2, 596 people with fibromyalgia. BMC Musculoskelet Disord 8:27\nOkifuji A, Bradshaw DH, Olson C (2009) Evaluating obesity in fibromyalgia: neuroendocrine biomarkers, symptoms, and functions. Clin Rheumatol 28(4):475–478\nWallace DJ, Hallegua DS (2004) Fibromyalgia: the gastrointestinal link. Curr Pain Headache Rep 8(5):364–368\nBellanti JA, Sabra A, Castro HJ, Chavez JR, Malka-Rais J, de Inocencio JM. (2005) Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? What is fibromyalgia? Allergy Asthma Proc Jan-Feb;26(1):19–28\nChang L (1998) The association of functional gastrointestinal disorders and fibromyalgia. Eur J Surg 164:32–36\nNorth CS, Hong BA, Alpers DH (2007) Relationship of functional gastrointestinal disorders and psychiatric disorders: implications for treatment. World J Gastroenterol 13(14):2020\nErdogan S, Gurer G, Afsin H, Kucukzeybek Y (2011) Evaluation of gastric emptying rate in patients with fibromyalgia: a case control study. Mod Rheumatol 21(2):174–177\nMadsen C (1997) Prevalence of food allergy\u002Fintolerance in Europe. Environ Toxicol Pharmacol 4(1–2):163–167\nSchäfer T, Böhler E, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, Filipiak B, Wichmann H (2001) Epidemiology of food allergy\u002Ffood intolerance in adults: associations with other manifestations of atopy. Allergy 56(12):1172–1179\nZuberbier T, Edenharter G, Worm M, Ehlers I, Reimann S, Hantke T, Roehr CC, Bergmann KE, Niggemann B (2004) Prevalence of adverse reactions to food in Germany–a population study. Allergy 59(3):338–345\nMadsen C (2005) Prevalence of food allergy: an overview. Proc Nutr Soc 64:413–417\nZimmerman GL, Olsen CG, Bosworth MF (2000) ‘Stages of change’ approach to helping patients change behavior. Am Fam Physician 61:1409–1416\nWorsley A (2002) Nutrition knowledge and food consumption: can nutrition knowledge change food behaviour? Asia Pac J Clin Nutr 11(Suppl):S579–S585\nHaugen M, Kjeldsen-Kragh J, Nordvåg B, Førre Ø (1991) Diet and disease symptoms in rheumatic diseases—Results of a questionnaire based survey. Clin Rheumatol 10(4):401–407\nOrtolani C (1999) Controversial aspects of adverse reactions to food. Allergy 54(1):27–45\nHolton KF, Kindler LL, Jones KD (2009) Potential dietary links to central sensitization in fibromyalgia: past reports and future directions. Rheum Dis Clin N Am 35(2):409–420\nStata Corp (2009) Stata Users Guide Release 11. Stata Press, College Station",{"VOID":1634},"10.1007\u002Fs00296-011-2010-z","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00296-011-2010-z",[1637,1652,1667],{"id":1638,"sortIndex":32,"researcher":28,"roles":1639,"affiliations":1640,"properties":1649,"displayName":1651,"givenName":28,"familyName":28},"66d7cd18-02db-4057-b902-b05d77b8005d",[1050],[1641],{"id":1642,"sortIndex":32,"affiliation":1643,"properties":28},"68868735-5277-4fcc-858a-65e2179f8425",{"id":1642,"createTime":28,"updateTime":28,"relativeEntities":1644,"slug":28,"properties":1645,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1648,"statistic":28},[],{"title":1646},{"EN":1647},"Faculty of Pharmacy, University of Barcelona, Barcelona, Spain",[],{"title":1650},{"VI":1651},"Laura-Isabel Arranz",{"id":1653,"sortIndex":40,"researcher":28,"roles":1654,"affiliations":1655,"properties":1664,"displayName":1666,"givenName":28,"familyName":28},"359bb9ca-3c6d-433c-9cbf-0aeb6cbee622",[1050],[1656],{"id":1657,"sortIndex":32,"affiliation":1658,"properties":28},"02410a8d-aae8-41e0-8d30-40b00aa14983",{"id":1657,"createTime":28,"updateTime":28,"relativeEntities":1659,"slug":28,"properties":1660,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1663,"statistic":28},[],{"title":1661},{"VI":1662},"Department of Managerial Decision Sciences, IESE Business School, University of Navarra, Barcelona, Spain",[],{"title":1665},{"VI":1666},"Miguel-Ángel Canela",{"id":1668,"sortIndex":123,"researcher":28,"roles":1669,"affiliations":1670,"properties":1677,"displayName":1679,"givenName":28,"familyName":28},"aebc2226-165c-4f43-af6a-c30b45768f9a",[1050],[1671],{"id":1642,"sortIndex":32,"affiliation":1672,"properties":28},{"id":1642,"createTime":28,"updateTime":28,"relativeEntities":1673,"slug":28,"properties":1674,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1676,"statistic":28},[],{"title":1675},{"EN":1647},[],{"title":1678},{"VI":1679},"Magda Rafecas",{"url":1635,"publisher":1681,"properties":1730},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1682,"slug":872,"properties":1683,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1686,"manageAffiliations":1699,"indexDatabases":1710,"url":28,"thumbnailPath":28,"statistic":1725,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"issn":1684,"title":1685},{"VOID":875},{"EN":877},[1687,1691,1695],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":1688,"label":1689,"description":1690,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1692,"label":1693,"description":1694,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1696,"label":1697,"description":1698,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},[1700,1705],{"id":900,"createTime":28,"updateTime":28,"relativeEntities":1701,"slug":28,"properties":1702,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1704,"statistic":28},[],{"title":1703},{"EN":904},[906],{"id":908,"createTime":28,"updateTime":28,"relativeEntities":1706,"slug":28,"properties":1707,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1709,"statistic":28},[],{"title":1708},{"EN":912},[906],[1711,1718],{"id":916,"indexDatabase":1712,"url":922,"indexYears":923,"academicFieldIds":1717,"indexDatabaseRanking":928},{"id":792,"createTime":28,"updateTime":28,"relativeEntities":1713,"label":1714,"description":1715,"key":798,"publicationTags":1716,"standard":28},[],{"EN":795,"VI":795},{"EN":795,"VI":797},[800],[925,926,927],{"id":930,"indexDatabase":1719,"url":942,"indexYears":28,"academicFieldIds":1724,"indexDatabaseRanking":28},{"id":932,"createTime":28,"updateTime":28,"relativeEntities":1720,"label":1721,"description":1722,"key":939,"publicationTags":1723,"standard":28},[],{"EN":935,"VI":935},{"EN":937,"VI":938},[941,785],[944],{"impactFactor":32,"impactFactorByYear":1726,"i10Index":948,"i10IndexLast5Year":516,"totalPublication":949,"totalPublicationByYear":1727,"totalCitation":964,"totalCitationByYear":1728,"totalCitationPerPublication":373,"totalCitationPerPublicationByYear":1729,"hindexLast5Year":328,"hindex":328},{"2012":113,"2013":222,"2014":119,"2015":696,"2016":422,"2017":582,"2018":320,"2019":224,"2020":222,"2021":228,"2022":947,"2023":338},{"1981":51,"1982":140,"1983":132,"1984":142,"1985":133,"1986":150,"1987":352,"1988":133,"1989":352,"1990":142,"1991":202,"1992":141,"1993":69,"1994":142,"1995":138,"1996":133,"1997":136,"1998":134,"1999":69,"2000":133,"2001":208,"2002":436,"2003":951,"2004":952,"2005":953,"2006":362,"2007":529,"2008":954,"2009":459,"2010":607,"2011":955,"2012":956,"2013":957,"2014":578,"2015":958,"2016":837,"2017":959,"2018":960,"2019":961,"2020":605,"2021":962,"2022":963,"2023":211,"2024":145},{"1981":155,"1982":829,"1983":966,"1984":142,"1985":140,"1986":207,"1987":967,"1988":968,"1989":332,"1990":969,"1991":141,"1992":834,"1993":970,"1994":971,"1995":149,"1996":161,"1997":560,"1998":972,"1999":973,"2000":968,"2001":959,"2002":974,"2003":975,"2004":976,"2005":977,"2006":978,"2007":979,"2008":980,"2009":981,"2010":982,"2011":983,"2012":984,"2013":985,"2014":986,"2015":987,"2016":988,"2017":989,"2018":990,"2019":991,"2020":992,"2021":993,"2022":210},{"1981":376,"1982":995,"1983":996,"1984":40,"1985":997,"1986":705,"1987":998,"1988":999,"1989":343,"1990":1000,"1991":741,"1992":1001,"1993":1002,"1994":579,"1995":1003,"1996":186,"1997":1004,"1998":1005,"1999":1006,"2000":999,"2001":1007,"2002":1008,"2003":1009,"2004":1010,"2005":1011,"2006":1012,"2007":1013,"2008":1014,"2009":1015,"2010":1015,"2011":1016,"2012":1002,"2013":1017,"2014":587,"2015":1018,"2016":1019,"2017":1020,"2018":442,"2019":1021,"2020":1022,"2021":1023,"2022":288},{"pages":1731,"volume":1733},{"VOID":1732},"2615-2621",{"VOID":1734},"32","2011-07-22",2011,[928,941],{"id":1739,"createTime":1740,"updateTime":1741,"relativeEntities":1742,"slug":1743,"properties":1744,"entityType":1043,"verifyStatus":26,"verifyTime":1753,"verifyNote":1044,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1754,"fullTextUrl":28,"authors":1755,"publicationType":1091,"publisherRelationship":1829,"citationCount":28,"citationInfo":28,"publishDate":1883,"publishYear":1884,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1885,"openAccess":28,"references":28,"isForceReanalyzing":1150},"00b47302-cc26-4a27-abe1-dbb8ff691491","2023-12-13T16:46:26.863+00:00","2025-02-11T09:12:35.987+00:00",[],"The-effect-of-TNF-alpha-blockers-on-psychometric-measures-in-ankylosing-spondylitis-patients-a-preliminary-observation",{"abstract":1745,"title":1747,"references":1749,"doi":1751},{"EN":1746},"There is a high co-morbidity between chronic inflammatory disorders and depression. Proinflammatory cytokines like TNF-α seem to play a central role in the pathogenesis of these disorders, and its neutralization provides a potent treatment for inflammatory disorders. Few studies showed that TNF-α blockers also caused an improvement in depressive symptoms associated with these chronic inflammatory disorders. To evaluate the effectiveness of TNF-α blockers on symptoms of ankylosing spondylitis (AS), depression, anxiety and quality of life, 9 AS patients resistant to classical therapy were enrolled and followed-up at 2nd and 6th weeks after a TNF-α blocker was started. Hamilton Depression and Anxiety Scales (HAM-D, HAM-A), Hospital Depression and Anxiety Questionnaire (HAD), Quality of Life Scale (SF36) and AS severity index (BASDAI) were applied to the patients at weeks 0, 2 and 6. ESR and CRP were evaluated to monitor biological disease activity. There was a significant reduction in HAM-D (p = 0.00), HAM-A (p = 0.00), HAD anxiety scores (p = 0.02) and a significant improvement in SF36 physical function (p = 0.00), physical role limitations (p = 0.00), bodily pain (p = 0.05), general health (p = 0.01), vitality (p = 0.03) and emotional role limitations (p = 0.00) subscales, BASDAI scores (p = 0.00), ESR (p = 0.00) and CRP (p = 0.00). Change in clinical disease activity (BASDAI) was not correlated with change in depression–anxiety scores, while change in biological disease activity (CRP) was correlated with change in depression–anxiety scores. TNFα blockers may have a potential antidepressant effect besides its anti-inflammatory effect that seems to be independent of its clinical effect.",{"EN":1748},"The effect of TNF-alpha blockers on psychometric measures in ankylosing spondylitis patients: a preliminary observation",{"VOID":1750},"Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet 369:1379–1390\nOrtancil O, Konuk N, May H, Sanli A, Ozturk D, Ankarali H (2010) Psychological status and patient-assessed health instruments in ankylosing spondylitis. J Clin Rheumatol 16:313–316\nBarlow JH, Macey SJ, Struthers GR (1993) Gender, depression and ankylosing spondylitis. Arthritis Care Res 6:45–51\nZink A, Braun J, Listing J, Wollenhaupt J (2000) Disability and handicap in rheumatoid arthritis and ankylosing spondylitis-results from the German rheumatological database. J Rheumatol 27:613–622\nMartindale J, Smith J, Sutton CJ, Grennan D, Goodacre L, Goodacre JA (2006) Disease and psychological status in ankylosing spondylitis. Rheumatology 45:1288–1293\nEvans DL, Charney DS, Lewis L et al (2005) Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry 58:175–189\nRaison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27:24–31\nLeonard BE (2010) The concept of depression as a dysfunction of the immune system. Curr Immunol Rev 6:205–212\nSchiepers OJ, Wichers MC, Maes M (2005) Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 29:201–217\nDantzer R (2001) Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci 933:222–234\nPatten SB (2006) Psychiatric side effects of interferon treatment. Curr Drug Saf 1:143–150\nDantzer R, Capuron L, Irwin MR et al (2008) Identification and treatment of symptoms associated with ınflammation in medically ıll patients. Psychoneuroendocrinology 33:18–29\nDowlati Y, Herrmann N, Swardfager W et al (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67:446–457\nReynolds JL, Ignatowski TA, Sud R, Spengler RN (2005) An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission. Neuroscience 133:519–531\nTuglu C, Kara SH, Caliyurt O, Vardar E, Abay E (2003) Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder. Psychopharmacology 170:429–433\nBradley JR (2008) TNF-mediated inflammatory disease. J Pathol 214:149–160\nBraun J, Sieper J (2003) Overview of the use of the anti-TNF agent infliximab in chronic inflammatory diseases. Expert Opin Biol Ther 3:141–168\nLange U, Teichmann J, Stracke H (2000) Correlation between plasma TNF-alpha, IGF-1, biochemical markers of bone metabolism, markers of inflammation\u002Fdisease activity, and clinical manifestations in ankylosing spondylitis. Eur J Med Res 29:507–511\nSonel B, Tutkak H, Duzgun N (2002) Serum levels of IL-1 beta, TNF-alpha, IL-8, and acute phase proteins in seronegative spondyloarthropathies. Joint Bone Spine 69:463e467\nChou CT, Huo AP, Chang HN, Tsai CY, Chen WS, Wang HP (2007) Cytokine production from peripheral blood mononuclear cells in patients with ankylosing spondylitis and their first-degree relatives. Arch Med Res 38:190–195\nKozaci LD, Sari I, Alacacioglu A, Akar S, Akkoc N (2010) Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor. Mod Rheumatol 20:34–39\nFrech T (2007) Treatment of ankylosing spondylitis: focus on etanercept. Biologics 1:45–51\nLin J, Ziring D, Desai S et al (2008) TNFalpha blockade in human diseases: an overview of efficacy and safety. Clin Immunol 126:13–30\nBraun J, Pham T, Sieper J, Davis J, van der Linden S, Dougados M, van der Heijde D; ASAS Working Group (2003) International ASAS consensus statement for the use of anti-tumour necrosis factor agents in patients with ankylosing spondylitis. Ann Rheum Dis 62:817–824\nSilva LC, Ortigosa LC, Benard G (2010) Anti-TNF-α agents in the treatment of immune-mediated inflammatory diseases: mechanisms of action and pitfalls. Immunotherapy 2:817–833\nLoftus EV, Feagan BG, Colombel JF et al (2008) Effects of adalimumab maintenance therapy on health-related quality of life of patients with Crohn’s disease: patient-reported outcomes of the CHARM trial. Am J Gastroenterol 103:3132–3141\nFernández Lisón LC, Vázquez Domínguez B, Luis Fernández J, Moreno Alvarez P, Fruns Giménez I, Liso Rubio J (2008) Quality of life of patients with rheumatoid arthritis undergoing out-patient treatment with TNF inhibitors. Farm Hosp 32:178–181\nAbalos-Medina GM, Ruiz-Villaverde G, Sánchez-Cano D, Ruiz-Villaverde R, Ocaña-Peinado F, Villaverde-Gutiérrez C (2010) Functional level and quality of life in ankylosing spondylitis, pilot study after 16 weeks TNF blocker treatment. Rev Esp Geriatr Gerontol 45:331–334\nTyring S, Gottlieb A, Papp K et al (2006) Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomized phase III trial. Lancet 367:29–35\nPersoons P, Vermeire S, Demyttenaere K et al (2005) The impact of major depressive disorder on the short- and long-term outcome of Crohn’s disease treatment with infliximab. Aliment Pharmacol Ther 22:101–110\nLichtenstein GR, Bala M, Han C, DeWoody K, Schaible T (2002) Infliximab improves quality of life in patients with Crohn’s disease. Inflamm Bowel Dis 8:237–243\nMinderhoud IM, Samsom M, Oldenburg B (2007) Crohn’s disease, fatigue, and infliximab: is there a role for cytokines in the pathogenesis of fatigue? World J Gastroenterol 13:2089–2093\nErtenli İ, Ozer S, Kiraz S et al (2010) Infliximab, a TNF-alpha antagonist treatment in patients with ankylosing spondylitis: the impact on depression, anxiety and quality of life level. Rheumatol Int. doi:10.1007\u002Fs00296-010-1616-x\nBerthold-Losleben M, Heitmann S, Himmerich H (2009) Anti-inflammatory drugs in psychiatry. Inflamm Allergy Drug Targets 8:266–276\nAkkoc Y, Karatepe AG, Akar S, Kirazli Y, Akkoc N (2005) A Turkish version of the Bath Ankylosing Spondylitis Disease Activity İndex: reliability and validity. Rheumatol Int 25:280–284\nAydemir Ö, Güvenir T, Küey L et al (1997). Reliability and validity of Turkish version of Hospital Depression and Anxiety Questionnaire. Turk Psik Derg 8:280–287 (Turkish)\nAkdemir A, Örsel S, Dağ I et al (1996) Reliability and validity of Turkish version of Hamilton Depression Scale. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 4:251–259 [Turkish]\nYazıcı MK, Demir B, Tanrıverdi N et al (1998) Interrater reliability and validity of Turkish version of Hamilton Anxiety Scale. Türk Psikiyatri Dergisi 9:114–117 [Turkish]\nKocyiğit H, Aydemir Ö, Ölmez N et al (1992) Reliability and validity of Turkish version of Short Form 36 (SF-36). İlaç ve Tedavi Dergisi 12:102–106 [Turkish]\nBaysal O, Durmus B, Ersoy Y et al (2011) Relationship between psychological status and disease activity and quality of life in ankylosing spondylitis. Rheumatol Int 31:795–800\nEren I, Sahin M, Cure E et al (2007) Interactions between psychiatric symptoms and disability and quality of life in ankylosing spondylitis patients. Arch Neuropsychiatry 44:1–9\nWichers M, Maes M (2002) The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans. Int J Neuropsychopharmacol 5:375–388\nMyint AM, Kim YK (2003) Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Med Hypothesis 61:519–525\nZhu CB, Blakely RD, Hewlett WA (2006) The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacol 31:2121–2131\nRaison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, Haroon E, Miller AH (2012) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. Arch Gen Psychiatry 3:1–11. doi:10.1001\u002F2013",{"VOID":1752},"10.1007\u002Fs00296-013-2671-x","2025-02-11T09:12:35.986+00:00","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00296-013-2671-x",[1756,1771,1786,1801,1814],{"id":1757,"sortIndex":32,"researcher":28,"roles":1758,"affiliations":1759,"properties":1768,"displayName":1770,"givenName":28,"familyName":28},"fdceef83-f92b-4fb2-aa68-077adeb40845",[1050],[1760],{"id":1761,"sortIndex":32,"affiliation":1762,"properties":28},"8b789902-e7d8-4935-8a28-5ca168079856",{"id":1761,"createTime":28,"updateTime":28,"relativeEntities":1763,"slug":28,"properties":1764,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1767,"statistic":28},[],{"title":1765},{"VI":1766},"Department of Psychiatry, Medical Faculty, Abant Izzet Baysal University, Bolu, Turkey",[],{"title":1769},{"VI":1770},"Ozden Arısoy",{"id":1772,"sortIndex":40,"researcher":28,"roles":1773,"affiliations":1774,"properties":1783,"displayName":1785,"givenName":28,"familyName":28},"32e8a35b-8dc6-44a1-9f46-2e1756e04222",[1050],[1775],{"id":1776,"sortIndex":32,"affiliation":1777,"properties":28},"982a366c-57ea-481d-b881-18230bbc13bb",{"id":1776,"createTime":28,"updateTime":28,"relativeEntities":1778,"slug":28,"properties":1779,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1782,"statistic":28},[],{"title":1780},{"VI":1781},"Department of Rheumatology, Bakırköy State Hospital, İstanbul, Turkey",[],{"title":1784},{"VI":1785},"Cemal 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7,"doi":1899},{"EN":1894},"Diagnosing hypermobile Ehlers–Danlos syndrome (hEDS) remains challenging, despite new 2017 criteria. Patients not fulfilling these criteria are considered to have hypermobile spectrum disorder (HSD). Our first aim was to evaluate whether patients hEDS were more severely affected and had higher prevalence of extra-articular manifestations than HSD. Second aim was to compare their outcome after coordinated physical therapy. Patients fulfilling hEDS\u002FHSD criteria were included in this real-life prospective cohort (November 2017\u002FApril 2019). They completed a 16-item Clinical Severity Score (CSS-16). We recorded bone involvement, neuropathic pain (DN4) and symptoms of mast cell disorders (MCAS) as extra-articular manifestations. After a standardized initial evaluation (T0), all patients were offered the same coordinated physical therapy, were followed-up at 6 months (T1) and at least 1 year later (T2), and were asked whether or not their condition had subjectively improved at T2. We included 97 patients (61 hEDS, 36 HSD). Median age was 40 (range 18–73); 92.7% were females. Three items from CSS-16 (pain, motricity problems, and bleeding) were significantly more severe with hEDS than HSD. Bone fragility, neuropathic pain and MCAS were equally prevalent. At T2 (20 months [range 18–26]) 54% of patients reported improvement (no difference between groups). On multivariable analysis, only family history of hypermobility predicted (favorable) outcome (p = 0.01). hEDS and HDS patients showed similar disease severity score except for pain, motricity problems and bleeding, and similar spectrum of extra-articular manifestations. Long-term improvement was observed in > 50% of patients in both groups. These results add weight to a clinical pragmatic proposition to consider hEDS\u002FHSD as a single entity that requires the same treatments.",{"EN":1896},"Are patients with hypermobile Ehlers–Danlos syndrome or hypermobility spectrum disorder so different?",{"VOID":1898},"Remvig L, Jensen DV, Ward RC (2007) Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J Rheumatol 34:804–809\nQuatman CE, Ford KR, Myer GD et al (2008) The effects of gender and pubertal status on generalized joint laxity in young athletes. J Sci Med Sport 11:257–263. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jsams.2007.05.005\nColombi M, Dordoni C, Chiarelli N, Ritelli M (2015) Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome\u002Fehlers-danlos syndrome hypermobility type compared to other heritable connective tissue disorders. Am J Med Genet C Semin Med Genet 169C:6–22. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.c.31429\nMohamed M, Voet M, Gardeitchik T, Morava E (2014) Cutis Laxa. Adv Exp Med Biol 802:161–184. https:\u002F\u002Fdoi.org\u002F10.1007\u002F978-94-007-7893-1_11\nBonafe L, Cormier-Daire V, Hall C et al (2015) Nosology and classification of genetic skeletal disorders: 2015 revision. Am J Med Genet A 167A:2869–2892. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.a.37365\nAubry-Rozier B, Unger S, Bregou A, et al. [News in osteogenesis imperfecta: from research to clinical management]. Rev Med Suisse 2015;11:657–8, 60–2. - Search Results. In: PubMed. Accessed 2 Aug 2021\nLafage-Proust M-H, Courtois I (2019) The management of osteogenesis imperfecta in adults: state of the art. Joint Bone Spine 86:589–593. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jbspin.2019.02.001\nCorrado B, Ciardi G (2018) Hypermobile Ehlers-Danlos syndrome and rehabilitation: taking stock of evidence based medicine: a systematic review of the literature. J Phys Ther Sci 30:843–847. https:\u002F\u002Fdoi.org\u002F10.1589\u002Fjpts.30.847\nde Ferranti SD KE. Physical activity and exercise in patients with congenital heath disease, Literature review current through: Feb 2019. 2019;[cited 2019 Nov 10]. Available from: https:\u002F\u002Fwww.uptodate.com\u002Fcontents\u002Fphysical-activityand-exercise-in-pat - Search Results. In: PubMed. Accessed 2 Aug 2021\nTerry RH, Palmer ST, Rimes KA et al (2015) Living with joint hypermobility syndrome: patient experiences of diagnosis, referral and self-care. Fam Pract 32:354–358. https:\u002F\u002Fdoi.org\u002F10.1093\u002Ffampra\u002Fcmv026\nMalfait F, Francomano C, Byers P et al (2017) The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet 175:8–26. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.c.31552\nZweers MC, Bristow J, Steijlen PM et al (2003) Haploinsufficiency of TNXB is associated with hypermobility type of Ehlers-Danlos syndrome. Am J Hum Genet 73:214–217. https:\u002F\u002Fdoi.org\u002F10.1086\u002F376564\nMorissette R, Chen W, Perritt AF et al (2015) Broadening the spectrum of ehlers danlos syndrome in patients with congenital adrenal hyperplasia. J Clin Endocrinol Metab 100:E1143-1152. https:\u002F\u002Fdoi.org\u002F10.1210\u002Fjc.2015-2232\nDe Wandele I, Calders P, Peersman W et al (2014) Autonomic symptom burden in the hypermobility type of Ehlers-Danlos syndrome: a comparative study with two other EDS types, fibromyalgia, and healthy controls. Semin Arthritis Rheum 44:353–361. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.semarthrit.2014.05.013\nTinkle B, Castori M, Berglund B et al (2017) Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome Type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural history. Am J Med Genet C Semin Med Genet 175:48–69. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.c.31538\nMcGillis L, Mittal N, Santa Mina D et al (2020) Utilization of the 2017 diagnostic criteria for hEDS by the Toronto GoodHope Ehlers-Danlos syndrome clinic: a retrospective review. Am J Med Genet A 182:484–492. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.a.61459\nCopetti M, Morlino S, Colombi M et al (2019) Severity classes in adults with hypermobile Ehlers-Danlos syndrome\u002Fhypermobility spectrum disorders: a pilot study of 105 Italian patients. Rheumatology (Oxford) 58:1722–1730. https:\u002F\u002Fdoi.org\u002F10.1093\u002Frheumatology\u002Fkez029\nEller-Vainicher C, Bassotti A, Imeraj A et al (2016) Bone involvement in adult patients affected with Ehlers-Danlos syndrome. Osteoporos Int 27:2525–2531. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00198-016-3562-2\nCazzato D, Castori M, Lombardi R et al (2016) Small fiber neuropathy is a common feature of Ehlers-Danlos syndromes. Neurology 87:155–159. https:\u002F\u002Fdoi.org\u002F10.1212\u002FWNL.0000000000002847\nGaisl T, Giunta C, Bratton DJ et al (2017) Obstructive sleep apnoea and quality of life in Ehlers-Danlos syndrome: a parallel cohort study. Thorax 72:729–735. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fthoraxjnl-2016-209560\nSeneviratne SL, Maitland A, Afrin L (2017) Mast cell disorders in Ehlers-Danlos syndrome. Am J Med Genet C Semin Med Genet 175:226–236. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.c.31555\nAtwell K, Michael W, Dubey J et al (2021) Diagnosis and management of hypermobility spectrum disorders in primary care. J Am Board Fam Med 34:838–848. https:\u002F\u002Fdoi.org\u002F10.3122\u002Fjabfm.2021.04.200374\nYew KS, Kamps-Schmitt KA, Borge R (2021) Hypermobile ehlers-danlos syndrome and hypermobility spectrum disorders. Am Fam Physician 103:481–492\nBennett SE, Walsh N, Moss T, Palmer S (2021) Developing a self-management intervention to manage hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS): an analysis informed by behaviour change theory. Disabil Rehabil. https:\u002F\u002Fdoi.org\u002F10.1080\u002F09638288.2021.1933618\nDemes JS, McNair B, Taylor MRG (2020) Use of complementary therapies for chronic pain management in patients with reported Ehlers-Danlos syndrome or hypermobility spectrum disorders. Am J Med Genet A 182:2611–2623. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.a.61837\nVermeulen S, De Mits S, De Ridder R et al (2020) Altered multi-segment ankle and foot kinematics during gait in patients with Hypermobile Ehlers-Danlos Syndrome\u002FHypermobility spectrum disorder. A case-control study Arthritis Care Res (Hoboken). https:\u002F\u002Fdoi.org\u002F10.1002\u002Facr.24526\nHamonet C BI, Pommeret St, Pommeret S, Amoretti R, Baeza-Velasco, Metlaine A. Ehlers-Danlos Syndrome type III (hypermobile) : clinical somatosensory scale (SSCS-62) validation, about 626 patients. . Bull Acad Natle Méd 2017;201:405–15. - Search Results. In: PubMed. Accessed 2 Aug 2021\nBouhassira D, Attal N, Alchaar H et al (2005) Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 114:29–36. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.pain.2004.12.010\nJesudas R, Chaudhury A, Laukaitis CM (2019) An update on the new classification of Ehlers-Danlos syndrome and review of the causes of bleeding in this population. Haemophilia 25:558–566. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fhae.13800\nCastori M, Hakim A (2017) Contemporary approach to joint hypermobility and related disorders. Curr Opin Pediatr 29:640–649. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMOP.0000000000000541\nWilliams AN (2019) Ehlers-Danlos syndromes: new labels confuse everyone. BMJ 367:l6095. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj.l6095\nKahana M, Feinstein A, Tabachnic E et al (1987) Painful piezogenic pedal papules in patients with Ehlers-Danlos syndrome. J Am Acad Dermatol 17:205–209. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0190-9622(87)70192-3\nBorgström F, Karlsson L, Ortsäter G et al (2020) Fragility fractures in Europe: burden, management and opportunities. Arch Osteoporos 15:59. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11657-020-0706-y\nFormenti AM, Doga M, Frara S et al (2019) Skeletal fragility: an emerging complication of Ehlers-Danlos syndrome. Endocrine 63:225–230. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12020-018-1822-y\nBanica T, Coussens M, Verroken C et al (2020) Higher fracture prevalence and smaller bone size in patients with hEDS\u002FHSD-a prospective cohort study. Osteoporos Int 31:849–856. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00198-019-05269-z\nSyx D, De Wandele I, Rombaut L, Malfait F (2017) Hypermobility, the Ehlers-Danlos syndromes and chronic pain. Clin Exp Rheumatol 35(Suppl 107):116–122\nKohn A, Chang C (2020) The relationship between hypermobile ehlers-danlos syndrome (hEDS), postural orthostatic tachycardia syndrome (POTS), and mast cell activation syndrome (MCAS). Clin Rev Allergy Immunol 58:273–297. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12016-019-08755-8\nDaens S, Grossin D, Hermanns-Lê T et al (2018) Severe Mast Cell Activation Syndrome in a 15-year-old patient with an hypermobile Ehlers-Danlos syndrome. Rev Med Liege 73:61–64\nSimmonds JV, Herbland A, Hakim A et al (2019) Exercise beliefs and behaviours of individuals with Joint Hypermobility syndrome\u002FEhlers-Danlos syndrome - hypermobility type. Disabil Rehabil 41:445–455. https:\u002F\u002Fdoi.org\u002F10.1080\u002F09638288.2017.1398278\nTinkle BT (2020) Symptomatic joint hypermobility. Best Pract Res Clin Rheumatol 34:101508. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.berh.2020.101508\nCoussens M, Calders P, Lapauw B et al (2021) Does muscle strength change over time in patients with hypermobile ehlers-danlos syndrome\u002Fhypermobility spectrum disorder? an eight-year follow-up study. Arthritis Care Res (Hoboken) 73:1041–1048. https:\u002F\u002Fdoi.org\u002F10.1002\u002Facr.24220\nScheper MC, Juul-Kristensen B, Rombaut L et al (2016) Disability in adolescents and adults diagnosed with hypermobility-related disorders: a meta-analysis. Arch Phys Med Rehabil 97:2174–2187. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.apmr.2016.02.015\nEngelbert RHH, Juul-Kristensen B, Pacey V et al (2017) The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome\u002Fhypermobile Ehlers Danlos syndrome. Am J Med Genet C Semin Med Genet 175:158–167. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.c.31545\nHope L, Juul-Kristensen B, Løvaas H et al (2019) Subjective health complaints and illness perception amongst adults with Joint Hypermobility Syndrome\u002FEhlers-Danlos Syndrome-HypermobilityType - a cross-sectional study. Disabil Rehabil 41:333–340. https:\u002F\u002Fdoi.org\u002F10.1080\u002F09638288.2017.1390695\nBathen T, Hångmann AB, Hoff M et al (2013) Multidisciplinary treatment of disability in ehlers-danlos syndrome hypermobility type\u002Fhypermobility syndrome: A pilot study using a combination of physical and cognitive-behavioral therapy on 12 women. Am J Med Genet A 161A:3005–3011. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fajmg.a.36060\nDemmler JC, Atkinson MD, Reinhold EJ et al (2019) Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: a national electronic cohort study and case-control comparison. 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lung disease (ILD) carries a risk for severe pneumonia in patients with rheumatoid arthritis (RA). Bronchiectasis, another risk of severe pneumonia, has not been well elucidated in RA. We investigated the types of respiratory diseases in RA and correlated them to severe pneumonia during the course of treatment using biologic DMARDs (bDMARDs), with special attention to bronchiectasis and ILD. RA patients were examined by computed tomography before starting bDMARDs and divided into three groups: normal, bronchiectasis and ILD. The log-rank test and Dunnett’s multiple comparisons test were employed for the statistical analysis. Among 424 patients, 350 were categorized as normal, 32 as having bronchiectasis, and 42 as having ILD. Two in the normal group, three in the bronchiectasis group and four in the ILD group developed severe pneumonia. The log-rank test showed a significant difference among the three groups (p \u003C 0.0001). The pneumonia-free rates in the bronchiectasis and ILD groups were significantly lower than the normal group, respectively, with Dunnett’s multiple comparison test (p \u003C 0.0001). This study suggests that the bronchiectasis that occurs in RA carries a risk of severe pneumonia during treatment with bDMARDs that is comparable to ILD.",{"EN":2096},"Bronchiectasis is as crucial as interstitial lung disease in the severe pneumonia that occurs during treatment with biologic DMARDs in rheumatoid arthritis: a retrospective cohort study in a single facility",{"VOID":2098},"Boyadzieva VV, Stoilov N, Stoilov RM, Tachkov K, Kamusheva M, Petrova GI (2018) Quality of life and cost study of rheumatoid arthritis therapy with biological medicines. Front Pharmacol 9:794. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphar.2018.00794\nManova M, Savova A, Vasileva M, Terezova S, Kamusheva M, Grekova D, Petkova V, Petrova G (2018) Comparative price analysis of biological products for treatment of rheumatology arthritis. Front Pharmacol 9:1070. https:\u002F\u002Fdoi.org\u002F10.3889\u002Ffphar.2018.01070\nRutherford AI, Subesinghe S, Hyrich KL, Galloway JB (2018) Serious infection across biologic-treated patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for rheumatoid arthrits. Ann Rheum Dis 77:905–910. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fannrheumdis-2017-212825\nAccortt NA, Bonafede MM, Collier DH, Iles J, Curtis JR (2016) Risk of subsequent infection among patients receiving tumor necrosis factor inhibitors and other disease-modifying antirheumatic drugs. Arthritis Rheumatol 68:67–76. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fart.39416\nShaw M, Collins BF, Ho LA, Raghu G (2015) Rheumatoid arthritis-associated lung disease. Eur Respir Rev 24:1–16. https:\u002F\u002Fdoi.org\u002F10.1183\u002F09059180.00008014\nKelly CA, Saravanan V, Nisar M, Arthanari S, Woodhead FA, Price-Forbes AN, Dawson J, Sathi N, Ahmad Y, Koduri G, Young A (2014) Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics—a large multicentre UK study. Rheumatology (Oxford) 53:1676–1682. https:\u002F\u002Fdoi.org\u002F10.1093\u002Frheumatology\u002Fkeu165\nWilczynska MM, Condliffe AM, McKeon DJ (2013) Coexistence of bronchiectasis and rheumatoid arthritis: revisited. Respir Care 58:694–701. https:\u002F\u002Fdoi.org\u002F10.4187\u002Frespcare.01857\nYun H, Xie F, Delzell E, Levitan EB, Chen L, Lewis JD, Saag KG, Beukelman T, Winthrop KL, Baddley JW, Curtis JR (2016) Comparative risk of hospitalized infection associated with biologic agents in rheumatoid arthritis patients enrolled in medicare. Arthritis Rheumatol 68:56–66. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fart.39399\nGeri G, Dadoun S, Bui T, Del Castillo PN, Paternotte S, Dougados M, Gossec L (2011) Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases. BMC Infect Dis 11:304. https:\u002F\u002Fdoi.org\u002F10.1186\u002F147-2334-11-304\nNaidich DP, Webb RW, Grenier PA (2005) Imaging of the airways functional and radiologic correlations, 1st edn. Lippincott Williams & Wilkins, Philadelphia\nSingh JA (2016) Infections with biologics in rheumatoid arthritis and related conditions: a scoping review of serious or hospitalized infections in observational studies. Curr Rheumatol Rep 18:61. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11926-016-0609-5\nMori S, Yoshitama T, Hidaka T, Sakai F, Hasegawa M, Hashiba Y, Suematsu E, Tatsukawa H, Mizokami A, Yoshizawa S, Hirakata N, Ueki Y (2017) Comparative risk of hospitalized infection between biological agents in rheumatoid arthritis patients: a multicenter retrospective cohort study in Japan. PLoS ONE 12:e0179179. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0179179\nJinno S, Lu N, Jafarzadeh SR, Dubreuil M (2018) Trends in hospitalizations for serious Infections in patients with rheumatoid arthritis in the US between 1993 and 2013. Arthritis Care Res (Hoboken) 70:652–658. https:\u002F\u002Fdoi.org\u002F10.1002\u002Facr.23328\nZamora-Legoff JA, Krause ML, Crowson CS, Crowson CS, Ryu JH, Matteson EL (2016) Risk of serious infection in patients with rheumatoid arthritis-associated interstitial lung disease. Clin Rheumatol 35:2585–2589. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10067-016-3357-z\nWeycker D, Hansen GL, Seifer FD (2017) Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013. Chron Respir Dis 14:377–384. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1479972317709649\nMori S, Cho I, Koga Y, Sugimoto M (2008) Comparison of pulmonary abnormalities on high-resolution computed tomography in patients with early versus longstanding rheumatoid arthritis. J Rheumatol 35:1513–1521\nTuresson C, O’Fallon WM, Crowson CS, Gabriel SE, Matteson EL (2003) Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Ann Rheum Dis 62:722–727. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fard.62.8.722\nMyasoedova E, Crowson CS, Turesson C, Gabriel SE, Matteson EL (2011) Incidence of extraarticular rheumatoid arthritis in Olmsted County, Minnesota, in 1995–2007 versus 1985–1994: a population-based study. J Rheumatol 38:983–989. https:\u002F\u002Fdoi.org\u002F10.3899\u002Fjrheum.101133\nKoduri G, Norton S, Young A, Cox N, Davies P, Devlin J, Dixey J, Gough A, Prouse P, Winfield J, Williams P (2010) Interstitial lung disease has a poor prognosis in rheumatoid arthritis: results from an inception cohort. Rheumatology (Oxford) 49:1483–1489. https:\u002F\u002Fdoi.org\u002F10.1093\u002Frheumatology\u002Fkeq035\nSpagnolo P, Lee JS, Sverzellati N, Rossi G, Cottin V (2018) The lung in rheumatoid arthritis: focus on interstitial lung disease. Arthritis Rheumatol 70:1544–1554. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fart.40574\nMori S, Koga Y, Sugimoto M (2012) Different risk factors between interstitial lung disease and airway disease in rheumatoid arthritis. Respir Med 106:1591–1599. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.rmed.2012.07.006\nHutchinson D, Clarke A, Heesom K, Murphy D, Eggleton P (2017) Carbamylation\u002Fcitrullination of IgG Fc in bronchiectasis, established RA with bronchiectasis and RA smokers: a potential risk factor for disease. ERJ Open Res. https:\u002F\u002Fdoi.org\u002F10.1183\u002F2312054.00018-2017\nPerry E, Eggleton P, De Soyza A, Hutchinson D, Kelly C (2017) Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. Int J Rheum Dis 20:2003–2011. https:\u002F\u002Fdoi.org\u002F10.1111\u002F1756-185X.12702\nYin Y, Liang D, Zhao L, Li Y, Liu W, Ren Y, Zeng X, Zhang F, Tang F, Shan G, Zhang X (2014) Anti-cyclic citrullinated peptide antibody is associated with interstitial lung disease in patients with rheumatoid arthritis. 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macrophages play an outstanding role in many rheumatic diseases. However, traditional serum-containing tissue-culture techniques hamper in vitro studies due to fibroblast activation not found in vivo. The objective of this study was to examine dissociated synovial cells in a macrophage-selective, serum-free tissue-culture medium. Osteoarthritis synovial tissue (n=11) was cultured in Iscove’s Modified Dulbecco’s Medium (IMDM) with 10% fetal bovine serum (FBS) and compared to a serum-free, insulin-supplemented medium. After 9–11 and 19–21 days in vitro, immunohistochemistry was performed for macrophage\u002Flymphocyte markers and cell division. Cytokine profiles were determined by RT-PCR. In serum, cells with a bipolar morphology rapidly proliferated. Respectively, 14.34±12.94% and 13.25±12.66% expressed CD68 and HLA-DR. These markers further decreased after one passage. In serum-free medium, proliferation was infrequent, and cells with diverse morphologies expressed 83.10±6.80% and 55.03±6.88% CD68 and HLA-DR respectively. CD14 was rare, and lymphocytes were missing. Both cultures expressed interleukin-6 and interleukin-8. This novel serum-free method permits the culture of distinct CD68\u002FHLA-DR associated phenotypes.",{"EN":2241},"Macrophage-like synoviocytes display phenotypic polymorphisms in a serum-free tissue-culture medium",{"VOID":2243},"Flesch IE, Kaufmann SH (1999) Effect of fetal calf serum on cytokine release by bone marrow-derived macrophages during infection with intracellular bacteria. Immunobiology 200:120–127\nSassa S, Wolpe S, Cerami A (1987) Inhibition of erythroid differentiation of mouse erythroleukemia cells by a macrophage product(s). Blood Cells 13(1–2):161–169\nPeschle C, Testa U, Valtieri M, Gabbianelli M, Pelosi E, Montesoro E, Sposi NM, Fossati C, Camagna A, Care A (1993) Stringently purified human hematopoietic progenitors\u002Fstem cells: analysis of cellular\u002Fmolecular mechanisms underlying early hematopoiesis. Stem Cells 11(5):356–370\nWillems R, Henckaerts E, Lenjou M, Nijs G, Rodrigus I, Moulijn AC, Slegers H, Berneman ZN, Van Bockstaele DR (2001) Establishment of serum-free pre-colony forming unit assays for differentiation of primitive hematopoietic progenitors: serum induces early macrophage differentiation and inhibits early erythroid differentiation of CD34++CD38− cells. Ann Hematol 80(1):17–25\nPlesner A, Greenbaum CJ, Lernmark A (2001) Low serum conditions for in vitro generation of human macrophages with macrophage colony stimulating factor. J Immunol Methods 249:53–61\nBurg S, Zschabitz A, Stofft E (1991) Effect of different media on long-term cultivation of human synovial macrophages. Z Rheumatol 50:142–150\nDemaziere A (1993) Macrophages in rheumatoid synovial membrane: an update. Rev Rhum Ed Fr 60:568–579\nQu Z, Garcia CH, O’Rourke LM, Planck SR, Kohli M, Rosenbaum JT (1994) Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen\u002Fcyclin, c-myc, and nucleolar organizer region staining. Arthritis Rheum 37:212–220\nSchaser K, Kinne RW, Beil H, Kladny B, Stoss H (1996) Proliferation of T-cells, macrophages, neutrophilic granulocytes and fibroblast-like cells in the synovial membrane of patients with rheumatoid arthritis. Verh Dtsch Ges Pathol 80:276–280\nIscove NN, Melchers F (1978) Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes. J Exp Med 147:923–933\nSeidel MF, Keck R, Vetter H (1997) ICAM-1\u002FLFA-1 expression in acute osteodestructive joint lesions in collagen-induced arthritis in rats. J Histochem Cytochem 45:1247–1253\nSchwartz GN, Hudgins WR, Perdue JF (1993) Glycosylated insulin-like growth factor II promoted expansion of granulocyte-macrophage colony-forming cells in serum-deprived liquid cultures of human peripheral blood cells. Exp Hematol 21(11):1447–1454\nKoch AE, Burrows JC, Skoutelis A, Marder R, Domer PH, Anderson B, Leibovich SJ (1991) Monoclonal antibodies detect monocyte\u002Fmacrophage activation and differentiation antigens and identify functionally distinct subpopulations of human rheumatoid synovial tissue macrophages. Am J Pathol 138:165–173\nAthanasou NA, Quinn J (1991) Immunocytochemical analysis of human synovial lining cells: phenotypic relation to other marrow derived cells. Ann Rheu Dis 50:311–315\nWilkinson LS, Pitsillides AA, Edwards JC (1993) Giant cells in arthritic synovium. Ann Rheum Dis 52:182–184\nGadher SJ, Woolley DE (1987) Comparative studies of adherent rheumatoid synovial cells in primary culture: characterisation of the dendritic (stellate) cell. Rheumatol Int 7:13–22\nSchlaak JF, Pfers I, Meyer Zum Buschenfelde KH, Marker-Hermann E (1996) Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies. Clin Exp Rheumatol 14:155–162\nKaneko S, Satoh T, Chiba J, Ju C, Inoue K, Kagawa J (2000) Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. Cytokines Cell Mol Ther 6:71–79\nNeumann E, Judex M, Masuda K, Distler O, Schaumburger J, Kullmann F, Grifka J, Gay RE, Schölmerich J, Gay S, Müller-Ladner U (2002) Altered gene expression pattern in rheumatoid arthritis synovial fibroblasts after few cultures passages. Ann Rheum Dis 61(suppl 1):59\nKonttinen YT, Nykänen P, Nordström D, Saari H, Sandelin J, Santavirta S et al (1989) DNA synthesis in prolyl 4-hydroxylase positive fibroblasts in situ in synovial tissue. An autoradiography-immunoperoxidase double labelling study. J Rheumatol 16:339–345\nKasper M, Schuh D, Muller M (1994) Immunohistochemical localization of the beta subunit of prolyl 4-hydroxylase in human alveolar epithelial cells. Acta Histochem 96(3):309–313\nAnnunen P, Autio-Harmainen H, Kivirikko KI (1998) The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells. J Biol Chem 13, 273(11):5989–5992\nNissi R, Autio-Harmainen H, Marttila P, Sormunen R, Kivirikko KI (2001) Prolyl 4-hydroxylase isoenzymes I and II have different expression patterns in several human tissues. J Histochem Cytochem 49(9):1143–1153\nZucchini A, Del Zotto G, Brando B, Canonico B (2001) CD90. J Biol Regul Homeost Agents 15(1):82–85\nHenniker AJ (2001) CD90. J Biol Regul Homeost Agents 15(4):392–393\nMurray LJ, Tsukamoto A, Hoffman R (1996) CD34+Thy-1+Lin- stem cells from mobilized peripheral blood. Leuk Lymphoma 22(1–2):37–42\nMalek TR, Fleming TJ, Codias EK (1994) Regulation of T lymphocyte function by glycosylphosphatidylinositol (GPI)-anchored proteins. Semin Immunol 6(2):105–113\nSummers KL, O’Donnell JL, Hoy MS, Peart M, Dekker J, Rothwell A, Hart DN (1995) Monocyte-macrophage antigen expression on chondrocytes. J Rheumatol 22(7):1326–1334\nFries KM, Blieden T, Looney RJ, Sempowski GD, Silvera MR, Willis RA, Phipps RP (1994) Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin Immunol Immunopathol 72(3):283–292\nMiyake S, Yagita H, Maruyama T, Hashimoto H, Miyasaka N, Okumura KJ (1993) Beta 1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients. Exp Med 177(3):863–868\nVater CA, Mainardi CL, Harris ED (1978) Activation in vitro of rheumatoid synovial collagenase from cell cultures. J Clin Invest 62(5):987–992\nKolkenbrock H, Ali HM, Hecker-Kia A, Buchlow G, Sorensen H, Hauer RW, Ulbrich N (1991) Characterization of a gelatinase from human rheumatoid synovial fluid cells. Eur J Clin Chem Clin Biochem 29(8):499–505\nDamsky C, Tremble P, Werb Z (1992) Signal transduction via the fibronectin receptor: do integrins regulate matrix remodeling? Matrix Suppl 1:184–191\nWolf J, Carsons S (1992) Fibronectin mediates anchorage-dependent focus formation in cultured human synoviocytes. Semin Arthritis Rheum 6:387–392\nXie DL, Hui F, Meyers R, Homandberg GA (1994) Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis. Arch Biochem Biophys 311:205–212\nGoddard DH (1992) Regulation of synovial cell growth by polypeptide growth factors. DNA Cell Biol 11:259–263\nTerhorst C, van Agthoven A, Reinherz E, Schlossman S (1980) Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5. Science 25:520–521\nLedbetter JA, Evans RL, Lipinski M, Cunningham-Rundles C, Good RA, Herzenberg LA (1981) Evolutionary conservation of surface molecules that distinguish T lymphocyte helper\u002Finducer and cytotoxic\u002Fsuppressor subpopulations in mouse and man. J Exp Med 1(153):310–323\nHaziot A, Chen S, Ferrero E, Low MG, Silber R, Goyert SM (1988) The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol 15(141):547–552\nHolness CL, Simmons DL (1993) Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 15(81):1607–1613\nvan Noesel CJ, van Lier RA, Cordell JL, Tse AG, van Schijndel GM, de Vries EF, Mason DY, Borst J (1991) The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene. J Immunol 1(146):3881–3888\nAdams TE, Bodmer JG, Bodmer WF (1983) Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human Ia alloantigens. Immunology 50:613–624\nMagaud JP, Sargent I, Clarke PJ, Ffrench M, Rimokh R, Mason DY (1989) Double immunocytochemical labeling of cell and tissue samples with monoclonal anti-bromodeoxyuridine. 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