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It plays a significant role in the body as a precursor to sex steroids as well as a lesser known role in the hypothalamic pituitary adrenal axis (HPA) response to stress. DHEA-S can be measured reliably in saliva, making saliva collection a valuable tool for health research because it minimizes the need for invasive sampling procedures (e.g., blood draws). Typical saliva collection methods include the use of plain cotton swab collection devices (e.g., Salivette®) or passive drool. There has been some speculation that the plain saliva cotton collection device may interfere with determination of DHEA-S by enzyme immunoassay (EIA) bringing this saliva collection method into question. Because of the increasing popularity of salivary biomarker research, we sought to determine whether the cotton swab interferes with DHEA-S determination through EIA techniques. Fifty-six healthy young adult men and women aged 18-30 years came to the lab in the morning (0800 hrs; 14 men, 14 women) or late afternoon (1600 hrs; 14 men, 14 women) and provided saliva samples via cotton Salivette and passive drool. Passive drool collection was taken first to minimize particle cross contamination from the cotton swab. Samples were assayed for DHEA-S in duplicate using a commercially available kit (DSL, Inc., Webster, TX). DHEA-S levels collected via Salivette and passive drool were positively correlated (r = + 0.83, p \u003C 0.05). Mean DHEA-S levels were not significantly different between collection methods. Salivary DHEA-S levels were significantly higher in males than in females, regardless of saliva collection method (p \u003C 0.05), and morning DHEA-S values were higher than evening levels (p \u003C 0.05). Results suggest that DHEA-S can be measured accurately using passive drool or cotton Salivette collection methods. Results also suggest that DHEA-S levels change across the day and that future studies need to take this time of day difference into account when measuring DHEA-S.",{"EN":163},"Measuring DHEA-S in saliva: time of day differences and positive correlations between two different types of collection methods",{"VOID":165},"[\"8492055482225296618\"]",{"VOID":167},"10.1186\u002F1756-0500-3-204","PUBLICATION","VERIFIED","2024-05-06T15:32:14.581+00:00","Auto 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Whetzel",{"id":191,"sortIndex":192,"researcher":18,"roles":193,"affiliations":194,"properties":201,"displayName":203,"givenName":18,"familyName":18},"f74fdae5-d69d-42cb-b175-1d501133eee7",1,[177],[195],{"id":180,"sortIndex":19,"affiliation":196,"properties":18},{"id":180,"createTime":18,"updateTime":18,"relativeEntities":197,"slug":18,"properties":198,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":200,"statistic":18},[],{"title":199},{"VI":185},[],{"title":202},{"VI":203},"Laura C 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TE, McEwen BS, Singer BH, Albert MS, Rowe JW: Increase in urinary cortisol excretion and memory declines. MacArthur studies of successful aging. J Clin Endocrinol Metab. 1997, 82 (8): 2458-2465. 10.1210\u002Fjc.82.8.2458.","http:\u002F\u002Fpress.endocrine.org\u002Fdoi\u002F10.1210\u002Fjcem.82.8.4173",{"doi":275},"10.1210\u002Fjc.82.8.2458",{"id":277,"text":278,"url":279,"identifiers":280},"e3cff216-07d1-4837-a53d-6c2edb97f8fc","Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS: Price of adaptation-allostatic load and its health consequences. MacArthur studies of successful aging. Arch Intern Med. 1997, 157 (19): 2259-2268. 10.1001\u002Farchinte.157.19.2259.","http:\u002F\u002Farchinte.ama-assn.org\u002Fcgi\u002Fdoi\u002F10.1001\u002Farchinte.157.19.2259",{"doi":281},"10.1001\u002Farchinte.157.19.2259",{"id":283,"text":284,"url":285,"identifiers":286},"4c68646b-0035-4279-8000-0006b275d4fa","Almeida DM, Piazza JR, Dmitrieva ND, Klein LC: Frontiers in the use of biomarkers of health in research on stress and aging. J Gerontol: Psych Sciences.","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":287},"10.1007\u002Fs10440-022-00541-7",{"id":283,"text":289,"url":285,"identifiers":290},"Di Luigi L, Guidetti C, Baldari MC, Gallotta P, Sgro P, Perroni F, Romanelli F, Lenzi A: Cortisol, dehydroepiandrosterone sulfate and dehydroepiandrosterone sulphate\u002Fcortisol ratio responses to physical stress in males are influenced by pubertal development. J Endocrinol Invest. 2006, 29: 796-804.",{"doi":287},{"id":283,"text":292,"url":285,"identifiers":293},"Huang YJ, Chen MT, Fang CL, Lee WC, Yang SC, Kuo CH: A possible link between exercise training adaptation and dehydroepiandrosterone-sulfate- an oldest-old female study. Int J Med Sci. 2006, 3 (4): 141-147.",{"doi":287},{"id":295,"text":296,"url":297,"identifiers":298},"51a95bc0-7a72-4d9a-89f4-2c1e88891349","Enomoto M, Adachi H, Fukami A, Furuki K, Satoh A, Otsuka M, Kumagae S, Nanjo Y, Shigetoh Y, Imaizumi T: Serum dehyroepiandrosterone sulfate levels predict longevity in men: 27-year follow-up study in a community-based cohort (Tanushimaru Study). J Am Geriatr Soc. 2008, 56 (6): 994-998. 10.1111\u002Fj.1532-5415.2008.01692.x.","https:\u002F\u002Fagsjournals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1532-5415.2008.01692.x",{"doi":299},"10.1111\u002Fj.1532-5415.2008.01692.x",{"id":301,"text":302,"url":303,"identifiers":304},"40ded8c5-657e-48f6-a887-4c7d09594a48","Davis SR, Shah SM, McKenzie DP, Kulkarni J, Davison SL, Bell RJ: Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol Metab. 2008, 93 (3): 801-808. 10.1210\u002Fjc.2007-2128.","https:\u002F\u002Facademic.oup.com\u002Fjcem\u002Farticle\u002F93\u002F3\u002F801\u002F2598380",{"doi":305},"10.1210\u002Fjc.2007-2128",{"id":307,"text":308,"url":309,"identifiers":310},"02013db7-8a42-43fe-8768-ca7d0a0f0319","Assies J, Visser I, Nicolson NA, Eggelte TA, Wekking EM, Huyser J, Lieverse R, Schene AH: Elevated salivary dehydroepiandrosterone-sulfate but normal cortisol levels in medicated depressed patients: preliminary findings. Psychiatry Res. 2004, 128 (2): 117-122. 10.1016\u002Fj.psychres.2004.05.016.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0165178104001325",{"doi":311},"10.1016\u002Fj.psychres.2004.05.016",{"id":18,"text":313,"url":314,"identifiers":315},"Taylor MK, Sausen KP, Potterat EG, Mujica-Parodi LR, Reis JP, Markham AE, Padilla GA, Taylor DL: Stressful military training: endocrine reactivity, performance, and psychological impact. Aviat Space Environ Med. 2007, 78 (12): 1143-1149. 10.3357\u002FASEM.2151.2007.","https:\u002F\u002Fdoi.org\u002F10.3357\u002Fasem.2151.2007",{"mag":316,"openalex":317,"pm":318,"doi":319},"2064715003","W2064715003","18064919","10.3357\u002Fasem.2151.2007",{"id":283,"text":321,"url":285,"identifiers":322},"Mommersteeg PM, Heijnen CJ, Kavelaars A, van Doornen LJ: The HPA-axis and immune function in burnout. Prog Brain Res. 2008, 167: 281-285. full_text.",{"doi":287},{"id":324,"text":325,"url":326,"identifiers":327},"c8a4d428-40b7-430a-8100-6d0b2d9834f2","Jeckel CM, Lopes RP, Berleze MC, Luz C, Feix L, Argimon II, Stein LM, Bauer ME: Neuroendocrine and immunological correlates of chronic stress in 'strictly healthy' populations. Neuroimmunomodulation. 2010, 17 (1): 9-18. 10.1159\u002F000243080.","https:\u002F\u002Fkarger.com\u002FNIM\u002Farticle\u002Fdoi\u002F10.1159\u002F000243080",{"doi":328},"10.1159\u002F000243080",{"id":330,"text":331,"url":332,"identifiers":333},"fea5f50c-fc91-478b-9103-8a4cc107b5b9","Shirtcliff EA, Granger DA, Schwartz E, Curran MJ: Use of salivary biomarkers in biobehavioral research: cotton-based sample collection methods can interfere with salivary immunoassay results. Psychoneuroendocrinology. 2001, 26: 165-173. 10.1016\u002FS0306-4530(00)00042-1.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0306453000000421",{"doi":334},"10.1016\u002Fs0306-4530(00)00042-1",{"id":336,"text":337,"url":338,"identifiers":339},"28dd4d5b-b848-4bf3-90f7-2394a8145be5","Kivilighan KT, Granger DA, Schwartz EB, Nelson V, Curran M, Shirtcliff EA: Quantifying blood leakage into the oral mucosa and its effects on the measurement of cortisol, dehydroepiandrosterone, and testosterone in saliva. Horm Behav. 2004, 46: 39-46. 10.1016\u002Fj.yhbeh.2004.01.006.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0018506X04000613",{"doi":340},"10.1016\u002Fj.yhbeh.2004.01.006",{"id":342,"text":343,"url":344,"identifiers":345},"d175de57-ea1c-485c-abfb-2f125b6dc0b1","Gallagher P, Leitch MM, Massey AE, McAllister-Williams RH, Young AH: Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method. J Psychopharmacol. 2006, 20 (5): 643-649. 10.1177\u002F0269881106060585.","https:\u002F\u002Fjournals.sagepub.com\u002Fdoi\u002F10.1177\u002F0269881106060585",{"doi":346},"10.1177\u002F0269881106060585",{"id":283,"text":348,"url":285,"identifiers":349},"Lamey PJ, Nolan A: The recovery of human saliva using the Salivette system. Eur J Clin Chem Clin Biochem. 1994, 32 (9): 727-728.",{"doi":287},{"id":351,"text":352,"url":353,"identifiers":354},"327f20cb-5119-47bb-a8ab-38df12667940","Groschl M, Rauh M: Influence of commercial collection devices for saliva on the reliability of salivary steroids analysis. Steroids. 2006, 71 (13-14): 1097-1100. 10.1016\u002Fj.steroids.2006.09.007.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0039128X06001954",{"doi":355},"10.1016\u002Fj.steroids.2006.09.007",{"id":357,"text":358,"url":359,"identifiers":360},"2c9b760f-36ce-44b5-a4f7-be939626078a","Groschl M, Kohler H, Topf HG, Rupprecht T, Rauh M: Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs. J Pharm Biomed Anal. 2008, 47 (3): 478-486. 10.1016\u002Fj.jpba.2008.01.033.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0731708508000617",{"doi":361},"10.1016\u002Fj.jpba.2008.01.033",{"id":363,"text":364,"url":365,"identifiers":366},"932f8d6c-c6ca-4b7c-a9d1-8ec309ad3b51","Orentreich N, Brind JL, Rizer RL, Vogelman JH: Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 1984, 59 (3): 551-555. 10.1210\u002Fjcem-59-3-551.","https:\u002F\u002Facademic.oup.com\u002Fjcem\u002Farticle-lookup\u002Fdoi\u002F10.1210\u002Fjcem-59-3-551",{"doi":367},"10.1210\u002Fjcem-59-3-551",{"id":369,"text":370,"url":371,"identifiers":372},"621b1fb3-de61-49d0-b4ba-7e0555df7be1","Hornsby PJ: Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline. Ann N Y Acad Sci. 1995, 774: 29-46. 10.1111\u002Fj.1749-6632.1995.tb17370.x.","https:\u002F\u002Fnyaspubs.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1749-6632.1995.tb17370.x",{"doi":373},"10.1111\u002Fj.1749-6632.1995.tb17370.x",{"id":375,"text":376,"url":377,"identifiers":378},"c0160dce-d7f1-4a65-8966-a895bc8101fe","Baulieu EE: Dehydroepiandrosterone (DHEA): a fountain of youth?. J Clin Endocrinol Metab. 1996, 81 (9): 3147-3151. 10.1210\u002Fjc.81.9.3147.","http:\u002F\u002Fpress.endocrine.org\u002Fdoi\u002F10.1210\u002Fjcem.81.9.8784058",{"doi":379},"10.1210\u002Fjc.81.9.3147",{"id":381,"text":382,"url":383,"identifiers":384},"a8190d68-c22a-4a7e-ac9b-2ee4dc52a9d3","Kroboth PD, Salek FS, Pittenger AL, Fabian TJ, Frye RF: DHEA and DHEA-S: a review. J Clin Pharmacol. 1999, 39 (4): 327-348. 10.1177\u002F00912709922007903.","https:\u002F\u002Faccp1.onlinelibrary.wiley.com\u002Fdoi\u002F10.1177\u002F00912709922007903",{"doi":385},"10.1177\u002F00912709922007903",{"id":387,"text":388,"url":389,"identifiers":390},"d0309124-66a3-4cc7-8370-730f6d4f05ef","Patacchioli FR, Monnazzi P, Simeoni S, De Filippis S, Salvatori E, Coloprisco G, Martelletti P: Salivary cortisol, dehydroepiandrosterone-sulphate (DHEA-S) and testosterone in women with chronic migraine. J Headache Pain. 2006, 7 (2): 90-94. 10.1007\u002Fs10194-006-0274-6.","https:\u002F\u002Fthejournalofheadacheandpain.biomedcentral.com\u002Farticles\u002F10.1007\u002Fs10194-006-0274-6",{"doi":391},"10.1007\u002Fs10194-006-0274-6",{"id":393,"text":394,"url":395,"identifiers":396},"fa8b9f7c-084f-4dc4-bc3b-2ca27468d3ef","Zhao ZY, Xie Y, Fu YR, Li YY, Bogdan A, Touitou Y: Circadian rhythm characteristics of serum cortisol and dehydroepiandrosterone sulfate in healthy Chinese men aged 30-60 years. A cross-sectional study. Steroids. 2003, 68 (2): 133-138. 10.1016\u002FS0039-128X(02)00167-8.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0039128X02001678",{"doi":397},"10.1016\u002Fs0039-128x(02)00167-8",{"id":283,"text":399,"url":285,"identifiers":400},"Del Ponte A, Di Monte MG, Graziani D, Guagnano MT, Menduni P, Vitullo F, Sensi S: Changes in plasma DHEAS circadian rhythm in elderly men. Prog Clin Biol Res. 1990, 341A: 791-796.",{"doi":287},{"id":283,"text":402,"url":285,"identifiers":403},"Nicolau GY, Haus E, Lakatua DJ, Bogdan C, Sackett-Lundeen L, Popescu M, Berg H, Petrescu E, Robu E: Circadian and circannual variations of FSH, LH, testosterone dehydroepiandrosterone-sulfate (DHEA-S) and 17-hydroxy progesterone (17 OH-Prog) in elderly men and women. Endocrinologie. 1985, 23 (4): 223-246.",{"doi":287},{"id":405,"text":406,"url":407,"identifiers":408},"78c60c5c-3e87-40eb-9946-977c857da172","Harmon AG, Hibel LC, Rumyantseva O, Granger DA: Measuring salivary cortisol in studies of child development: Watch out- what goes in may not come out of saliva collection devices. Dev Psychobiol. 2007, 49 (5): 495-500. 10.1002\u002Fdev.20231.","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fdev.20231",{"doi":409},"10.1002\u002Fdev.20231",{"id":283,"text":411,"url":285,"identifiers":412},"Klein LC, Corwin EJ, Ceballos RM: Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence. AddictBehav. 2004, 29 (5): 921-927.",{"doi":287},{"id":414,"text":415,"url":416,"identifiers":417},"8bf1dad7-996d-4312-969a-0530f4a66171","Whetzel CA, Corwin EJ, Klein LC: Disruption in Th1:Th2 immune response in young adult smokers. Addict Behav. 2007, 32 (1): 1-8. 10.1016\u002Fj.addbeh.2006.03.007.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0306460306000785",{"doi":418},"10.1016\u002Fj.addbeh.2006.03.007",{"id":420,"text":421,"url":422,"identifiers":423},"8a7d359d-1985-4f3b-82c4-6c0525945cd3","Goodyer IM, Herbert J, Altham PM, Pearson J, Secher SM, Shiers HM: Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychol Med. 1996, 26 (2): 245-256. 10.1017\u002FS0033291700034644.","https:\u002F\u002Fwww.cambridge.org\u002Fcore\u002Fproduct\u002Fidentifier\u002FS0033291700034644\u002Ftype\u002Fjournal_article",{"doi":424},"10.1017\u002Fs0033291700034644",{"id":426,"text":427,"url":428,"identifiers":429},"84ea571a-e779-46ab-bb7c-fc214f289cbc","Hucklebridge F, Hussain T, Evans P, Clow A: The diurnal patterns of the adrenal steroids cortisol and dehydroepiandrosterone (DHEA) in relation to awakening. Psychoneuroendocrinology. 2005, 30 (1): 51-57. 10.1016\u002Fj.psyneuen.2004.04.007.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS030645300400071X",{"doi":430},"10.1016\u002Fj.psyneuen.2004.04.007",{"id":432,"text":433,"url":434,"identifiers":435},"4b06e94f-bf98-40e1-9806-e66125ba72b3","Morgan CA, Rasmusson A, Pietrzak RH, Coric V, Southwick SM: Relationships among plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate, cortisol, symptoms of dissociation, and objective performance in humans exposed to underwater navigation stress. Biol Psychiatry. 2009, 66 (4): 334-340. 10.1016\u002Fj.biopsych.2009.04.004.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0006322309004466",{"doi":436},"10.1016\u002Fj.biopsych.2009.04.004",{"id":438,"text":439,"url":440,"identifiers":441},"d5c9b6a1-9c5e-4c05-8b48-fe75cb065c0e","Carlson LE, Speca M, Patel KD, Goodey E: Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology. 2004, 29 (4): 448-474. 10.1016\u002FS0306-4530(03)00054-4.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0306453003000544",{"doi":442},"10.1016\u002Fs0306-4530(03)00054-4",{"id":444,"text":445,"url":446,"identifiers":447},"2f6c6463-9729-4486-8875-481c6b73680b","de Bruin VM, Vieira MC, Rocha MN, Viana GS: Cortisol and dehydroepiandosterone sulfate plasma levels and their relationship to aging, cognitive function, and dementia. Brain Cogn. 2002, 50 (2): 316-323. 10.1016\u002FS0278-2626(02)00519-5.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0278262602005195",{"doi":448},"10.1016\u002Fs0278-2626(02)00519-5",{"id":450,"text":451,"url":452,"identifiers":453},"b8a2588c-009e-40de-988e-3ee5f5d3a505","Cruess DG, Antoni MH, Kumar M, Ironson G, McCabe P, Fernandez JB, Fletcher M, Schneiderman N: Cognitive-behavioral stress management buffers decreases in dehydroepiandrosterone sulfate (DHEA-S) and increases in the cortisol\u002FDHEA-S ratio and reduces mood disturbance and perceived stress among HIV-seropositive men. Psychoneuroendocrinology. 1999, 24 (5): 537-549. 10.1016\u002FS0306-4530(99)00010-4.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0306453099000104",{"doi":454},"10.1016\u002Fs0306-4530(99)00010-4",{"id":456,"text":457,"url":458,"identifiers":459},"7e5fd97b-f0a9-46c4-8c35-06a9555a8dca","Strazdins L, Meyerkort S, Brent V, D'Souza RM, Broom DH, Kyd JM: Impact of saliva collection methods on sIgA and cortisol assays and acceptability to participants. J Immunol Methods. 2005, 307 (1-2): 167-171. 10.1016\u002Fj.jim.2005.09.010.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0022175905003297",{"doi":460},"10.1016\u002Fj.jim.2005.09.010",false,{"id":463,"createTime":464,"updateTime":465,"relativeEntities":466,"slug":467,"properties":468,"entityType":168,"verifyStatus":169,"verifyTime":477,"verifyNote":171,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":478,"fullTextUrl":18,"authors":479,"publicationType":204,"publisherRelationship":578,"citationCount":628,"citationInfo":629,"publishDate":632,"publishYear":630,"citationAnalyzeStatus":266,"lastCitationAnalyze":465,"indexDatabases":633,"openAccess":18,"references":634,"isForceReanalyzing":461},"f1ab45f5-9b29-4cfa-8053-0ecbba04497d","2024-01-29T03:38:40.087+00:00","2026-08-18T19:18:18.650+00:00",[],"Coronary-calcium-scoring-are-the-results-comparable-to-computed-tomography-coronary-angiography-for-screening-coronary-artery-disease-in-a-South-Asian-population-",{"abstract":469,"title":471,"gsPaper":473,"doi":475},{"EN":470},"The need of having feasible screening tools like Coronary Calcium Scoring (CCS) and CT Coronary Artery (CTCA) for Coronary Artery Disease (CAD) has become paramount. We aimed to evaluate the accuracy of CCS in determining the degree of stenosis of coronary vessels as compared to that determined by CTCA in a South Asian population. A retrospective study was conducted at The Aga Khan University Hospital. A total of 539 patient records were reviewed who had undergone CCS and CTCA between 2008 and 2010. Patient records were reviewed by comparing their CCS and CTCA results. About 268 out of 301 (89%) patients with a CCS of 0–9 were found to be free of stenosis on CTCA. On a CCS of 10–99, 110 out of 121 (91%) patients were either free of stenosis or had mild stenosis. About 66 out of 79 (84%) patients had moderate or severe stenosis with a calcium score of 100–400 while none of the patients were free of stenosis. Around 28 out of 38 (74%) patients with a CCS of more than 400 had severe stenosis. However, only 04 patients (11%) were found to have mild stenosis. Spearman’s rho revealed a correlation coefficient of 0.791 with a p-value of \u003C0.001. Our study reaffirms that in South Asian population, low CCS (\u003C100) is associated with no or minimal stenosis while high CCS warrants further investigation; hence, making it a reliable tool for screening patients with CAD.",{"EN":472},"Coronary calcium scoring: are the results comparable to computed tomography coronary angiography for screening coronary artery disease in a South Asian 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MP: Hyperhomocysteinemia and coronary artery disease in Pakistan. J Pak Med Assoc. 2006, 56: 282-5.",{"doi":287},{"id":639,"text":640,"url":641,"identifiers":642},"e73b9253-f43e-412e-a2f7-13c22fa033e9","Jafar TH, Jafary FH, Jessani S, Chaturvedi N: Heart disease epidemic in Pakistan: women and men at equal risk. Am Heart J. 2005, 150: 221-6. 10.1016\u002Fj.ahj.2004.09.025.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS000287030400657X",{"doi":643},"10.1016\u002Fj.ahj.2004.09.025",{"id":18,"text":645,"url":18,"identifiers":646},"Mohan V, Deepa R, Rani SS, Premalatha G: Prevalence of coronary artery disease and its relationship to lipids in a selected population in South India: the Chennai Urban population study (CUPS No. 5). J Am Coll Cardiol. 2001, 38: 682-7. 10.1016\u002FS0735-1097(01)01415-2.",{"doi":647},"10.1016\u002FS0735-1097(01)01415-2",{"id":649,"text":650,"url":651,"identifiers":652},"a6de3be1-eb51-4960-9117-d51ec10cf393","Gaemperli O, Husmann L, Schepis T, Koepfli P, Valenta I, Jenni W, Alkadhi H, Lüscher TF, Kaufmann PA: Coronary CT angiography and myocardial perfusion imaging to detect flow-limiting stenoses: a potential gatekeeper for coronary revascularization?. Eur Heart J. 2009, 30: 2921-9. 10.1093\u002Feurheartj\u002Fehp304.","https:\u002F\u002Facademic.oup.com\u002Feurheartj\u002Farticle-lookup\u002Fdoi\u002F10.1093\u002Feurheartj\u002Fehp304",{"doi":653},"10.1093\u002Feurheartj\u002Fehp304",{"id":283,"text":655,"url":285,"identifiers":656},"Bowman AW, Kantor B, Gerber TC: Coronary computed tomographic angiography: current role in the diagnosis and management of coronary artery disease. Pol Arch Med Wewn. 2009, 119: 381-90.",{"doi":287},{"id":658,"text":659,"url":660,"identifiers":661},"e5c32cf3-7ed0-4fbb-8aec-faf5965efc0f","Tamarappoo BK, Gutstein A, Cheng VY, Nakazato R, Gransar H, Dey D, Thomson LE, Hayes SW, Friedman JD, Germano G, Slomka PJ, Berman DS: Assessment of the relationship between stenosis severity and distribution of coronary artery stenoses on multislice computed tomographic angiography and myocardial ischemia detected by single photon emission computed tomography. J Nucl Cardiol. 2010, 17: 791-802. 10.1007\u002Fs12350-010-9230-6.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12350-010-9230-6",{"doi":662},"10.1007\u002Fs12350-010-9230-6",{"id":664,"text":665,"url":666,"identifiers":667},"b384b9dd-1ee6-4e59-8bb1-9f54e9864d82","Xu Y, Tang L, Zhu X, Xu H, Tang J, Yang Z, Wang L, Wang D: Comparison of dual-source CT coronary angiography and conventional coronary angiography for detecting coronary artery disease. 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J Med Imaging Radiat Oncol. 2008, 52: 49-56. 10.1111\u002Fj.1440-1673.2007.01911.x.","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1440-1673.2007.01911.x",{"doi":680},"10.1111\u002Fj.1440-1673.2007.01911.x",{"id":18,"text":682,"url":683,"identifiers":684},"Johnson KM, Dowe DA: The detection of any coronary calcium outperforms Framingham risk score as a first step in screening for coronary atherosclerosis. AJR Am J Roentgenol. 2010, 194: 1235-43. 10.2214\u002FAJR.09.2487.","https:\u002F\u002Fdoi.org\u002F10.2214\u002Fajr.09.2487",{"mag":685,"openalex":686,"pm":687,"doi":688},"2072079236","W2072079236","20410409","10.2214\u002Fajr.09.2487",{"id":18,"text":690,"url":691,"identifiers":692},"Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA: Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008, 358: 1336-45. 10.1056\u002FNEJMoa072100.","https:\u002F\u002Fdoi.org\u002F10.1056\u002Fnejmoa072100",{"mag":693,"openalex":694,"pm":695,"doi":696},"1969678022","W1969678022","18367736","10.1056\u002Fnejmoa072100",{"id":698,"text":699,"url":700,"identifiers":701},"be522d99-a34e-4d7c-923f-0729fbff8d56","Khawaja A, Zubairi AB, Durrani FK, Zafar A: Etiology and outcome of severe community acquired pneumonia in immunocompetent adults. BMC Infect Dis. 2013, 13: 94-10.1186\u002F1471-2334-13-94.","https:\u002F\u002Fbmcinfectdis.biomedcentral.com\u002Farticles\u002F10.1186\u002F1471-2334-13-94",{"doi":702},"10.1186\u002F1471-2334-13-94",{"id":704,"text":705,"url":706,"identifiers":707},"e42d9c19-fde4-482f-8944-762034f59936","Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R: Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990, 15: 827-32. 10.1016\u002F0735-1097(90)90282-T.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002F073510979090282T",{"doi":708},"10.1016\u002F0735-1097(90)90282-t",{"id":18,"text":710,"url":18,"identifiers":711},"Wexler L, Brundage B, Crouse J, Detrano R, Fuster V, Maddahi J, Rumberger J, Stanford W, White R, Taubert K: Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications: a statement for health professionals from the American heart association: writing group. Circulation. 1996, 94: 1175-92. 10.1161\u002F01.CIR.94.5.1175.",{"doi":712},"10.1161\u002F01.CIR.94.5.1175",{"id":714,"text":715,"url":716,"identifiers":717},"c8a8bc12-85f9-4f04-9afc-6ed756804c31","Lau GT, Ridley LJ, Schieb MC, Brieger DB, Freedman SB, Wong LA, Lo SK, Kritharides L: Coronary artery stenoses: detection with calcium scoring, CT angiography, and both methods combined. Radiology. 2005, 235: 415-22. 10.1148\u002Fradiol.2352031813.","http:\u002F\u002Fpubs.rsna.org\u002Fdoi\u002F10.1148\u002Fradiol.2352031813",{"doi":718},"10.1148\u002Fradiol.2352031813",{"id":720,"text":721,"url":722,"identifiers":723},"cf95189c-e966-42ad-b4e1-08953e84629f","Cademartiri F, Maffei E, Palumbo A, Seitun S, Martini C, Tedeschi C, La Grutta L, Midiri M, Weustink AC, Mollet NR, Krestin GP: Coronary calcium score and computed tomography coronary angiography in high-risk asymptomatic subjects: assessment of diagnostic accuracy and prevalence of non-obstructive coronary artery disease. Eur Radiol. 2010, 20: 846-54. 10.1007\u002Fs00330-009-1612-2.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00330-009-1612-2",{"doi":724},"10.1007\u002Fs00330-009-1612-2",{"id":18,"text":726,"url":727,"identifiers":728},"Kelly JL, Thickman D, Abramson SD, Chen PR, Smazal SF, Fleishman MJ, Lingam SC: Coronary CT angiography findings in patients without coronary calcification. AJR Am J Roentgenol. 2008, 191: 50-5. 10.2214\u002FAJR.07.2954.","https:\u002F\u002Fdoi.org\u002F10.2214\u002Fajr.07.2954",{"mag":729,"openalex":730,"pm":731,"doi":732},"2082306010","W2082306010","18562724","10.2214\u002Fajr.07.2954",{"id":734,"text":735,"url":736,"identifiers":737},"4abadde9-4afe-4976-86b6-4dff4174297c","Einstein AJ, Henzlova MJ, Rajagopalan S: Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. JAMA. 2007, 298: 317-23. 10.1001\u002Fjama.298.3.317.","http:\u002F\u002Fjama.jamanetwork.com\u002Farticle.aspx?doi=10.1001\u002Fjama.298.3.317",{"doi":738},"10.1001\u002Fjama.298.3.317",{"id":740,"text":741,"url":742,"identifiers":743},"4e811768-4c89-42bd-b7b9-ca609b9dc5d7","Venkatesh V, Ellins ML, Yang S, Natarajan M, Amlani S, Sheth T: Incremental detection of coronary artery disease by assessment of non-calcified plaque on coronary CT angiography. Clin Radiol. 2009, 64: 250-5. 10.1016\u002Fj.crad.2008.09.009.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0009926008004315",{"doi":744},"10.1016\u002Fj.crad.2008.09.009",{"id":746,"text":747,"url":748,"identifiers":749},"f7ccac76-5e39-4f28-8908-87b1a9d60158","van Werkhoven JM, Schuijf JD, Gaemperli O, Jukema JW, Kroft LJ, Boersma E, Pazhenkottil A, Valenta I, Pundziute G, de Roos A, van der Wall EE, Kaufmann PA, Bax JJ: Incremental prognostic value of multi-slice computed tomography coronary angiography over coronary artery calcium scoring in patients with suspected coronary artery disease. Eur Heart J. 2009, 30: 2622-9. 10.1093\u002Feurheartj\u002Fehp272.","https:\u002F\u002Facademic.oup.com\u002Feurheartj\u002Farticle-lookup\u002Fdoi\u002F10.1093\u002Feurheartj\u002Fehp272",{"doi":750},"10.1093\u002Feurheartj\u002Fehp272",{"id":752,"text":753,"url":754,"identifiers":755},"b6bdb238-677b-4591-8c0c-97804398ca01","Akram K, O'Donnell RE, King S, Superko HR, Agatston A, Voros S: Influence of symptomatic status on the prevalence of obstructive coronary artery disease in patients with zero calcium score. Atherosclerosis. 2009, 203: 533-7. 10.1016\u002Fj.atherosclerosis.2008.07.008.","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0021915008005054",{"doi":756},"10.1016\u002Fj.atherosclerosis.2008.07.008",{"id":758,"text":759,"url":760,"identifiers":761},"882f7366-311e-413b-b215-67a9b610a547","Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT: Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Circulation. 1993, 87: 1179-87. 10.1161\u002F01.CIR.87.4.1179.","https:\u002F\u002Fwww.ahajournals.org\u002Fdoi\u002F10.1161\u002F01.CIR.87.4.1179",{"doi":762},"10.1161\u002F01.cir.87.4.1179",{"id":764,"text":765,"url":766,"identifiers":767},"860434c7-2265-45ce-90ae-57b99e96108d","Schmermund A, Erbel R: Unstable coronary plaque and its relation to coronary calcium. Circulation. 2001, 104: 1682-7. 10.1161\u002Fhc3901.093339.","https:\u002F\u002Fwww.ahajournals.org\u002Fdoi\u002F10.1161\u002Fhc3901.093339",{"doi":768},"10.1161\u002Fhc3901.093339",{"id":283,"text":770,"url":285,"identifiers":771},"Leber AW: Complementary use of coronary calcium scoring and CT angiography. 2005, Humana Press: CT of the Heart, 333-7.",{"doi":287},{"id":773,"text":774,"url":775,"identifiers":776},"707598b5-ad19-4ca6-997a-44a4dec244e0","Meijs MF, Meijboom WB, Prokop M, Mollet NR, van Mieghem CA, Doevendans PA, de Feyter PJ, Cramer MJ: Is there a role for CT coronary angiography in patients with symptomatic angina? Effect of coronary calcium score on identification of stenosis. Int J Cardiovasc Imaging. 2009, 25: 847-54. 10.1007\u002Fs10554-009-9485-7.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10554-009-9485-7",{"doi":777},"10.1007\u002Fs10554-009-9485-7",{"id":779,"createTime":780,"updateTime":781,"relativeEntities":782,"slug":783,"properties":784,"entityType":168,"verifyStatus":169,"verifyTime":795,"verifyNote":171,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":796,"fullTextUrl":18,"authors":797,"publicationType":204,"publisherRelationship":852,"citationCount":902,"citationInfo":903,"publishDate":906,"publishYear":630,"citationAnalyzeStatus":266,"lastCitationAnalyze":781,"indexDatabases":907,"openAccess":18,"references":18,"isForceReanalyzing":461},"5ffe465b-091c-4216-8104-205c6ef5b808","2023-11-25T05:47:55.083+00:00","2026-08-18T01:40:36.622+00:00",[],"Rheumatoid-arthritis-following-PEG-interferon-alfa-2a-plus-ribavirin-treatment-for-chronic-hepatitis-C-a-case-report-and-review-of-the-literature",{"abstract":785,"title":787,"gsPaper":789,"references":791,"doi":793},{"EN":786},"The combination of Pegylated Interferon-alpha (PEG-IFN-α) and ribavirin is the current standard of care for the treatment of HCV infection. Unfortunately, IFN-α may lead to the induction or exacerbation of autoimmune diseases, such as psoriasis, thyroiditis, systemic lupus erythematosus and, rarely, rheumatoid arthritis (RA). We report the case of a man affected with chronic hepatitis C (CHC) due to HCV genotype 3a infection, who developed RA after a complete course of PEG-IFN-α and ribavirin. Nine weeks after cessation of antiviral treatment, the patient developed symmetrical polyarthritis, with pain and edema in the wrists, knees, shoulders and metacarpophalangeal joints; magnetic resonance imaging detected initial bone erosions with juxta-articular osteopenia in wrist, knee and hand joints. Anti-cyclic citrullinated peptide (anti-CCP) antibodies were positive. Autoimmune diseases, including RA, may occur when treating chronic hepatitis C with PEG-IFN-α and ribavirin; therefore, a close surveillance for the occurrence of autoimmune phenomena should be suggested in the setting of HCV management.",{"EN":788},"Rheumatoid arthritis following PEG-interferon-alfa-2a plus ribavirin treatment for chronic hepatitis C: a case report and review of the literature",{"VOID":790},"[\"4038129592011373084\"]",{"VOID":792},"Alberti A, Chemello L, Benvegnu L: Natural history of hepatitis C. J Hepatol. 1999, 31: 17-24.\nBerretta M, Garlassi E, Cacopardo B, Cappellani A, Guaraldi G, Cocchi S, De Paoli P, Lleshi A, Izzi I, Torresin A, Di Gangi P, Pietrangelo A, Ferrari M, Bearz A, Berretta S, Nasti G, Di Benedetto F, Balestreri L, Tirelli U, Ventura P: Hepatocellular carcinoma in HIV-infected patients: check early, treat hard. Oncologist. 2011, 16 (9): 1258-1269. 10.1634\u002Ftheoncologist.2010-0400.\nCraxì A, Pawlotsky M, Wedemeyer H, Bjoro K, Flisiak R, Forns X, Mondelli M, Peck-Radosavljevic M, Rosenberg W, Sarrazin C, Jacobson I, Dusheiko G: EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. J Hepatol. 2011, 55 (2): 245-264.\nFried MW: Side effects of therapy of hepatitis C and their management. Hepatology. 2002, 36: S237-S244.\nWelsch C, Jesudian A, Zeuzem S, Jacobson I: New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives. Gut. 2012, 61 (S1): i36-46. Erratum in: Gut. 2012;61(8):1145\nNunnari G, Schnell MJ: MicroRNA-122: a therapeutic target for hepatitis C virus (HCV) infection. Front Biosci (Schol Ed). 2011, 3: 1032-1037.\nTomer Y: Hepatitis C and interferon induced thyroiditis. J Autoimmun. 2010, 34 (3): J322-326. 10.1016\u002Fj.jaut.2009.11.008.\nCacopardo B, Benanti F, Brancati G, Romano F, Nunnari A: Leucocyte interferon-alpha retreatment for chronic hepatitis C patients previously intolerant to other interferons. J Viral Hepat. 1998, 5 (5): 333-339. 10.1046\u002Fj.1365-2893.1998.00113.x.\nConrad B: Potential mechanisms of interferon-alpha induced autoimmunity. Autoimmunity. 2003, 36 (8): 519-523. 10.1080\u002F08916930310001602137.\nDumoulin FL, Leifeld L, Sauerbruch T, Spengler U: Autoimmunity induced by interferon-alpha therapy for chronic viral hepatitis. Biomed Pharmacother. 1999, 53 (5–6): 242-254.\nIzumi Y, Komori A, Yasunaga Y, Hashimoto S, Miyashita T, Abiru S, Yatsuhashi H, Ishibashi H, Migita K: Rheumatoid arthritis following a treatment with IFN-alpha\u002Fribavirin against HCV infection. Intern Med. 2011, 50 (9): 1065-1068. 10.2169\u002Finternalmedicine.50.4790.\nSood A, Midha V, Sood N: Rheumatoid arthritis probably induced by pegylated interferon in a patient with chronic hepatitis C. Indian J Gastroenterol. 2004, 23: 28-29.\nIonescu C, Micu L, Constantinescu I, Hortopan M, Ursaciuc C, Voiculescu M: Prolonged Treatment with Interferon Alpha and Peginterferon Induces Rheumatoid Artrhitis Syndrome and Erythema Nodosum. J Gastrointestin Liver Dis. 2008, 17 (2): 211-212.\nYang D, Arkfeld D, Fong TL: Development of Anti-CCP-positive Rheumatoid Arthritis Following Pegylated Interferon-α2a Treatment for Chronic Hepatitis C Infection. J Rheumatol. 2010, 37: 1777-10.3899\u002Fjrheum.100092.\nZuckerman E, Keren D, Rozenbaum M, Toubi E, Slobodin G, Tamir A, Naschitz JE, Yeshurun D, Rosner I: Hepatitis C virus related arthritis: characteristics and response to therapy with interferon alpha. Clin Exp Rheumatol. 2000, 18: 579-584. 10.1007\u002Fs100510070005.\nStroffolini T, Spadaro A, Guadagnino V, Cosentino S, Fatuzzo F, Galdieri A, Cacopardo B, Scalisi I, Sapienza M, Russello M, Scifo G, Frugiuele P, Foti G, Almasio PL, Gr.E. Ca.S. Hospitals’ Collaborating Group: Current practice of hepatitis C treatment in Southern Italy. Dig Liver Dis. 2010, 42 (11): 822-825. 10.1016\u002Fj.dld.2010.03.020.\nCacopardo B, Camma C, Petta S, Pinzone MR, Cappellani A, Zanghi A, Nicolosi A, Nunnari G: Diagnostic and therapeutical role of vitamin D in chronic hepatitis C virus infection. Front Biosci (Elite Ed). 2012, 4: 1276-1286.\nCacopardo B, Nunnari G, Benanti F, Cappellani A, Onorante A, Caltabiano E, Russo R: Leukocyte interferon alpha early retreatment for Child A HCV genotype 1b-infected cirrhotics intolerant to pegylated interferons. Infection. 2009, 37 (3): 210-215. 10.1007\u002Fs15010-008-8164-2.\nNunnari G, Montineri A, Portelli V, Savalli F, Fatuzzo F, Cacopardo B: The use of peginterferon in monotherapy or in combination with ribavirin for the treatment of acute hepatitis C. Eur Rev Med Pharmacol Sci. 2012, 16 (8): 1013-1016.\nYang JF, Kao YH, Dai CY, Huang JF, Hsieh MY, Lin ZY, Chen SC, Hsieh MY, Wang LY, Chuang WL, Yu ML: Comparison of adverse effects related to pegylated interferon-based therapy for patients with chronic hepatitis B and chronic hepatitis C in Taiwan. Hepatol Int. 2010, 4 (4): 732-740. 10.1007\u002Fs12072-010-9208-0.\nPinzone MR, Celesia BM, Di Rosa M, Cacopardo B, Nunnari G: Microbial translocation in chronic liver diseases. Int J Microbiol. 2012, 2012: 694629-\nDoutre MS: Hepatitis C virus-related skin diseases. Arch Dermatol. 1999, 135 (11): 1401-1403. 10.1001\u002Farchderm.135.11.1401.\nLiu Z, Bethunaickan R, Huang W: Interferon alpha accelerates murine SLE in a T cell-dependent manner. Arthritis Rheum. 2011, 63 (1): 219-229. 10.1002\u002Fart.30087.\nKrumbholz M, Faber H, Steinmeyer F, Hoffmann LA, Kümpfel T, Pellkofer H, Derfuss T, Ionescu C, Starck M, Hafner C, Hohlfeld R, Meinl E: Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain. 2008, 131: 1455-1463. 10.1093\u002Fbrain\u002Fawn077.\nBosello S, Youinou P, Daridon C, Tolusso B, Bendaoud B, Pietrapertosa D, Morelli A, Ferraccioli G: Concentrations of BAFF correlate with autoantibody levels, clinical disease activity, and response to treatment in early rheumatoid arthritis. J Rheumatol. 2008, 35: 1256-1264.",{"VOID":794},"10.1186\u002F1756-0500-6-437","2024-05-16T06:51:00.039+00:00","https:\u002F\u002Fbmcresnotes.biomedcentral.com\u002Farticles\u002F10.1186\u002F1756-0500-6-437",[798,813,826,839],{"id":799,"sortIndex":19,"researcher":18,"roles":800,"affiliations":801,"properties":810,"displayName":812,"givenName":18,"familyName":18},"0649514e-9774-44f9-bdcb-1527b9751acc",[177],[802],{"id":803,"sortIndex":19,"affiliation":804,"properties":18},"9796b9f5-ce9d-488c-8b21-5b569bfafc82",{"id":803,"createTime":18,"updateTime":18,"relativeEntities":805,"slug":18,"properties":806,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":809,"statistic":18},[],{"title":807},{"VI":808},"Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, ARNAS Garibaldi Nesima, Italy",[],{"title":811},{"VI":812},"Bruno Cacopardo",{"id":814,"sortIndex":192,"researcher":18,"roles":815,"affiliations":816,"properties":823,"displayName":825,"givenName":18,"familyName":18},"46d9d422-aeae-4804-8df4-88e6edae70be",[177],[817],{"id":803,"sortIndex":19,"affiliation":818,"properties":18},{"id":803,"createTime":18,"updateTime":18,"relativeEntities":819,"slug":18,"properties":820,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":822,"statistic":18},[],{"title":821},{"VI":808},[],{"title":824},{"VI":825},"Francesco 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study aimed at enhancing the transcriptomic resources for two sibling species of moths, Ostrinia scapulalis (Adzuki bean borer) and Ostrinia nubilalis (European corn borer), as a foundation for future researches on their divergence history. Previous works on these species had shown that their genetic divergence was low, while they were reproductively isolated in natura and specialized on different host plants. Comparative genomic resources will help facilitate the understanding of the mechanisms involved in this isolation and adaptation to the host plants. Despite their fundamental interest, these species still lack the genomic resources to thoroughly identify candidate genes for functions of interest. We present here a high throughput sequencing and de novo transcriptome assembly for these two sibling species in line with this objective of comparative genomics. Based on 322,504 and 307,622 reads of 454 sequencing for O. scapulalis and O. nubilalis respectively, we reconstructed 11,231 and 10,773 transcripts, of which 40% were functionally annotated by BLAST analyzes. We determined the level of completeness of both assemblies as well as the recovery level of published Ostrinia genomic resources. Gene ontology (GO) of common and species-specific de novo transcripts did not reveal GO terms significantly enriched in one or the other species. By applying stringent homology searches on transcripts common to O. scapulalis and O. nubilalis, we identified a set of homologous transcripts, with a mean nucleotide identity value of 98.1%. In this set, the most divergent transcripts revealed candidate genes involved in developmental, sensorial and pathogen defense processes. This data greatly increases the genomic resources of Ostrinia species and constitute a solid skeleton for future comparative analyzes of expression or diversity, despite we show that the transcriptomes for both species have not been assembled at full completion. In addition, we provide a set of homologous transcripts together with their annotation as a source of candidate genes for comparative analyzes.",{"EN":918},"De novo transcriptomic resources for two sibling species of moths: Ostrinia nubilalis and O. 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A, Monroe E: Taxonomy and distribution of the European corn borer and allied species: genus Ostrinia (lepidoptera: pyralidae). Memoirs of the Entomological Society of America. 1970, 71: 1-112.",{},{"id":18,"text":1063,"url":1064,"identifiers":1065},"Frolov AN, Bourguet D, Ponsard S: Reconsidering the taxomony of several Ostrinia species in the light of reproductive isolation: a tale for Ernst Mayr. Biol J Linn Soc. 2007, 91 (1): 49-72. 10.1111\u002Fj.1095-8312.2007.00779.x.","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1095-8312.2007.00779.x",{"mag":1066,"openalex":1067,"doi":1068},"1547276230","W1547276230","10.1111\u002Fj.1095-8312.2007.00779.x",{"id":18,"text":1070,"url":1071,"identifiers":1072},"Leniaud L, Audiot P, Bourguet D, Frérot B, Genestier G, Lee SF, Malausa T, Le Pallec A-H, Souqual M-C, Ponsard S: Genetic structure of European and Mediterranean maize borer populations on several wild and cultivated host plants. Entomol Exp Appl. 2006, 120 (1): 51-62. 10.1111\u002Fj.1570-7458.2006.00427.x.","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1570-7458.2006.00427.x",{"mag":1073,"openalex":1074,"doi":1075},"1981101625","W1981101625","10.1111\u002Fj.1570-7458.2006.00427.x",{"id":18,"text":1077,"url":1078,"identifiers":1079},"Malausa T, Dalecky A, Ponsard S, Audiot P, Streiff R, Chaval Y, Bourguet D: Genetic structure and gene flow in french populations of two Ostrinia taxa: host races or sibling species?. Mol Ecol. 2007, 16 (20): 4210-4222. 10.1111\u002Fj.1365-294X.2007.03457.x.","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1365-294x.2007.03457.x",{"mag":1080,"openalex":1081,"pm":1082,"doi":1083},"2115583858","W2115583858","17822415","10.1111\u002Fj.1365-294x.2007.03457.x",{"id":283,"text":1085,"url":285,"identifiers":1086},"Midamegbe A, Vitalis R, Malausa T, Delava E, Cros-Arteil S, Streiff R: Scanning the European corn borer (Ostrinia spp.) genome for adaptive divergence between host-affiliated sibling species. Mol Ecol. 2011, 20 (7): 1414-1430. 10.1111\u002Fj.1365-294X.2011.05035.x.",{"doi":287},{"id":18,"text":1088,"url":1089,"identifiers":1090},"Malausa T, Bethenod MT, Bontemps A, Bourguet D, Cornuet JM, Ponsard S: Assortative mating in sympatric host races of the European corn borer. Science. 2005, 308 (5719): 258-260. 10.1126\u002Fscience.1107577.","https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.1107577",{"mag":1091,"openalex":1092,"pm":1093,"doi":1094},"2030899973","W2030899973","15821092","10.1126\u002Fscience.1107577",{"id":18,"text":1096,"url":1097,"identifiers":1098},"Bethenod MT, Thomas Y, Rousset F, Frérot B, Pélozuelo L, Genestier G, Bourguet D: Genetic isolation between two sympatric host plant races of the European corn borer, Ostrinia nubilalis Hübner. II: assortative mating and host-plant preferences for oviposition. Heredity. 2005, 94 (2): 264-270. 10.1038\u002Fsj.hdy.6800611.","http:\u002F\u002Fdx.doi.org\u002F10.1038\u002Fsj.hdy.6800611",{"doi":1099},"10.1038\u002Fsj.hdy.6800611",{"id":18,"text":1101,"url":18,"identifiers":1102},"Pélozuelo L, Meusnier S, Audiot P, Bourguet D, Ponsard S: Assortative mating between European corn borer pheromone races: beyond assortative meeting. PLoS One. 2007, 2 (6): e555-10.1371\u002Fjournal.pone.0000555.",{"doi":1103},"555-10.1371\u002Fjournal.pone.0000555",{"id":18,"text":1105,"url":1106,"identifiers":1107},"Calcagno V, Thomas Y, Bourguet D: Sympatric host races of the European corn borer: adaptation to host plants and hybrid performance. J Evol Biol. 2007, 20 (5): 1720-1729. 10.1111\u002Fj.1420-9101.2007.01391.x.","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1420-9101.2007.01391.x",{"mag":1108,"openalex":1109,"pm":1110,"doi":1111},"1525030970","W1525030970","17714289","10.1111\u002Fj.1420-9101.2007.01391.x",{"id":283,"text":1113,"url":285,"identifiers":1114},"Malausa T, Pélissié B, Piveteau V, Pelissier C, Bourguet D, Ponsard S: Differences in oviposition behaviour of two sympatric sibling species of the genus Ostrinia. Bull Entomol Res. 2008, 98 (2): 193-201.",{"doi":287},{"id":283,"text":1116,"url":285,"identifiers":1117},"Pélozuelo L, Malosse C, Genestier G, Guenego H, Frérot B: Host-plant specialization in pheromone strains of the European corn borer Ostrinia nubilalis in France. J Chem Ecol. 2004, 30 (2): 335-352.",{"doi":287},{"id":18,"text":1119,"url":1120,"identifiers":1121},"Klun JA, Chapman O, Mattes K, Wojtkowski P, Beroza M: Insect sex pheromones: minor amount of opposite geometrical isomer critical to attraction. Science. 1973, 181: 661-663. 10.1126\u002Fscience.181.4100.661.","https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.181.4100.661",{"mag":1122,"openalex":1123,"pm":1124,"doi":1125},"2053587100","W2053587100","17736980","10.1126\u002Fscience.181.4100.661",{"id":1127,"text":1128,"url":1129,"identifiers":1130},"3e9e6c45-df7c-4739-8362-d4b0caaf5895","Kochansky J, Cardé RT, Liebherr J, Roelofs WL: Sex pheromone of the European corn borer, Ostrinia nubilalis (Lepidoptera: Pyralidae), in New York. J Chem Ecol. 1975, 1: 225-231. 10.1007\u002FBF00987871.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00987871",{"doi":1131},"10.1007\u002FBF00987871",{"id":18,"text":1133,"url":1134,"identifiers":1135},"Cardé RT, Roelofs W, Harrison R, Vawter A, Brussard P: European corn borer: pheromone polymorphism or sibling species?. Science. 1978, 199: 555-556. 10.1126\u002Fscience.199.4328.555.","https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.199.4328.555",{"mag":1136,"openalex":1137,"pm":1138,"doi":1139},"1969024991","W1969024991","17750022","10.1126\u002Fscience.199.4328.555",{"id":1141,"text":1142,"url":1143,"identifiers":1144},"62b96b44-ce09-4b91-bbe3-67989bcfc167","Huang YP, Takanashi T, Hoshizaki S, Tatsuki S, Ishikawa Y: Female sex pheromone polymorphism in Adzuki bean borer, Ostrinia scapulalis, is similar to that in European corn borer. O. nubilalis. Journal of Chemical Ecology. 2002, 28 (3): 533-539. 10.1023\u002FA:1014540011854.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1023\u002FA:1014540011854",{"doi":1145},"10.1023\u002FA:1014540011854",{"id":18,"text":1147,"url":1148,"identifiers":1149},"Bourguet D, Bethenod MT, Pasteur N, Viard F: Gene flow in the European corn borer Ostrinia nubilalis: implications for the sustainability of transgenic insecticidal maize. Proceedings of the Royal Society Biological Sciences. 2000, 267 (1439): 117-122. 10.1098\u002Frspb.2000.0975.","https:\u002F\u002Fdoi.org\u002F10.1098\u002Frspb.2000.0975",{"mag":1150,"pmc":1151,"openalex":1152,"pm":1153,"doi":1154},"2022379283","1690518","W2022379283","10687815","10.1098\u002Frspb.2000.0975",{"id":18,"text":1156,"url":1157,"identifiers":1158},"Bourguet D, Bethenod MT, Trouvé C, Viard F: Host-plant diversity of the European corn borer Ostrinia nubilalis: what value for sustainable transgenic insecticidal Bt maize?. Proceedings of the Royal Society Biological Sciences Series B. 2000, 267 (1449): 1177-1184. 10.1098\u002Frspb.2000.1126.","https:\u002F\u002Fdoi.org\u002F10.1098\u002Frspb.2000.1126",{"mag":1159,"pmc":1160,"openalex":1161,"pm":1162,"doi":1163},"1968239478","1690666","W1968239478","10902683","10.1098\u002Frspb.2000.1126",{"id":18,"text":1165,"url":1166,"identifiers":1167},"Martel C, Réjasse A, Rousset F, Bethenod MT, Bourguet D: Host-plant-associated genetic differentiation in Northern French populations of the European corn borer. Heredity. 2003, 90 (2): 141-149. 10.1038\u002Fsj.hdy.6800186.","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsj.hdy.6800186",{"mag":1168,"openalex":1169,"pm":1170,"doi":1171},"2006818947","W2006818947","12634820","10.1038\u002Fsj.hdy.6800186",{"id":18,"text":1173,"url":18,"identifiers":1174},"Thomas Y, Bethenod MT, Pélozuelo L, Frérot B, Bourguet D: Genetic isolation between two sympatric host-plant races of the European corn borer, Ostrinia nubilalis Hübner. 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Insect Biochemistry and Molecular Biology. 2011, 41 (9): 733-746. 10.1016\u002Fj.ibmb.2011.05.005.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS096517481100107X",{"doi":1278},"10.1016\u002Fj.ibmb.2011.05.005",{"id":1280,"text":1281,"url":1282,"identifiers":1283},"7d030180-0ff2-4229-979b-bcca0a0cf059","Lassance JM: Journey in the Ostrinia World: from pest to model in chemical ecology. Journal of Chemical Ecology. 2010, 36 (10): 1155-1169. 10.1007\u002Fs10886-010-9856-5.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10886-010-9856-5",{"doi":1284},"10.1007\u002Fs10886-010-9856-5",{"id":18,"text":1286,"url":18,"identifiers":1287},"Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P, Clark AG, Ribeiro JMC, Wides R: The genome sequence of the malaria mosquito Anopheles gambiae. 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Journal of Evolutionary Biology. 2010, 23 (9): 2004-2016. 10.1111\u002Fj.1420-9101.2010.02071.x.","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1420-9101.2010.02071.x",{"mag":1351,"openalex":1352,"pm":1353,"doi":1354},"1558919950","W1558919950","20695960","10.1111\u002Fj.1420-9101.2010.02071.x",{"id":18,"text":1356,"url":1357,"identifiers":1358},"Azam S, Thakur V, Ruperao P, Shah T, Balaji J, Amindala B, Farmer AD, Studholme DJ, May GD, Edwards D: Coverage based consensus calling (CBCC) of short sequence reads and comparison of CBCC results to identify SNPs in chickpea (Cicer arietinum, Fabaceae), a crop species without a reference genome. American Journal of Botany. 2012, 99 (2): 186-192. 10.3732\u002Fajb.1100419.","https:\u002F\u002Fdoi.org\u002F10.3732\u002Fajb.1100419",{"mag":1359,"openalex":1360,"pm":1361,"doi":1362},"2133048920","W2133048920","22301893","10.3732\u002Fajb.1100419",{"id":18,"text":1364,"url":1365,"identifiers":1366},"Rice P, Longden I, Bleasby A: EMBOSS: The European molecular biology open software suite. Trends in Genetics. 2000, 16 (6): 276-277. 10.1016\u002FS0168-9525(00)02024-2.","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0168-9525(00)02024-2",{"mag":1367,"openalex":1368,"pm":1369,"doi":1370},"1996423252","W1996423252","10827456","10.1016\u002Fs0168-9525(00)02024-2",{"id":1372,"createTime":1373,"updateTime":1374,"relativeEntities":1375,"slug":1376,"properties":1377,"entityType":168,"verifyStatus":169,"verifyTime":1386,"verifyNote":171,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1387,"fullTextUrl":18,"authors":1388,"publicationType":204,"publisherRelationship":1479,"citationCount":19,"citationInfo":1530,"publishDate":1533,"publishYear":1531,"citationAnalyzeStatus":266,"lastCitationAnalyze":1534,"indexDatabases":1535,"openAccess":18,"references":1536,"isForceReanalyzing":461},"48545d69-0349-469f-800d-4261c7652f76","2023-12-27T00:29:34.160+00:00","2026-08-16T01:18:26.090+00:00",[],"Pain-management-in-living-related-adult-donor-hepatectomy-feasibility-of-an-evidence-based-protocol-in-100-consecutive-donors",{"abstract":1378,"title":1380,"gsPaper":1382,"doi":1384},{"EN":1379},"Living donor hepatectomy (LDH) has important consequences in terms of acute and chronic pain. We proposed an anesthetic protocol based on the best currently available evidence. We report the results of this protocol’s application. We performed a retrospective descriptive study of 100 consecutive donors undergoing LDH. The protocol included standardized information provided by the anesthetist, pharmacological anxiolysis and preventive analgesia. Specifically, pregabalin premedication (opioid-free) intravenous anesthesia (with clonidine, ketamine, magnesium sulphate and ketorolac) and epidural analgesia were proposed. Postoperative follow-up was conducted by the Postoperative Pain Service. This analysis included 100 patients (53 women, 47 men, median age 32.7 years old [28.4–37.3]), operated by xypho-umbilical laparotomy. All elements of our anesthetic protocol were applied in over 75% of patients, except for the preoperative consultation with a senior anesthesiologist (55%). The median number of applied item was 7 [interquartile range, IQR 5–7]. Median postoperative pain scores were, at rest and at mobilization respectively 3 [IQR 2–4] and 6 [IQR 4.5–7] on day 1; 2 [IQR 1–3] and 5 [IQR 3–6] on day 2; and 2 [IQR 0–3] and 4 [IQR 3–5] on day 3. In conclusion, LDH leads to severe acute pain. Despite the proposal of a multimodal evidence-based protocol, its applicancy was not uniform and the pain scores remained relatively high.",{"EN":1381},"Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors",{"VOID":1383},"[\"8413991666672627960\"]",{"VOID":1385},"10.1186\u002Fs13104-018-3941-1","2024-04-29T16:23:19.537+00:00","https:\u002F\u002Fbmcresnotes.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13104-018-3941-1",[1389,1404,1417,1432,1449,1464],{"id":1390,"sortIndex":19,"researcher":18,"roles":1391,"affiliations":1392,"properties":1401,"displayName":1403,"givenName":18,"familyName":18},"f6c99377-f2dc-4ac8-b5af-af42667cdc7d",[177],[1393],{"id":1394,"sortIndex":19,"affiliation":1395,"properties":18},"cfc4487f-5124-48c3-94c3-7e9117fabb25",{"id":1394,"createTime":18,"updateTime":18,"relativeEntities":1396,"slug":18,"properties":1397,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1400,"statistic":18},[],{"title":1398},{"VI":1399},"Department of Anesthesiology, Cliniques universitaires Saint-Luc, Brussels, Belgium",[],{"title":1402},{"VI":1403},"Guillaume Dewe",{"id":1405,"sortIndex":192,"researcher":18,"roles":1406,"affiliations":1407,"properties":1414,"displayName":1416,"givenName":18,"familyName":18},"033bfe5c-5084-430a-8ba6-796b2fd3206f",[177],[1408],{"id":1394,"sortIndex":19,"affiliation":1409,"properties":18},{"id":1394,"createTime":18,"updateTime":18,"relativeEntities":1410,"slug":18,"properties":1411,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1413,"statistic":18},[],{"title":1412},{"VI":1399},[],{"title":1415},{"VI":1416},"Arnaud 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Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Arch Surg (Chicago, Ill: 1960). 2008;143:990–9 (discussion 1000).",{},{"id":283,"text":1684,"url":285,"identifiers":1685},"Wijeysundera DN, Beattie WS, Austin PC, Hux JE, Laupacis A. Epidural anaesthesia and survival after intermediate-to-high risk non-cardiac surgery: a population-based cohort study. Lancet (London, England). 2008;372:562–9.",{"doi":287},{"id":283,"text":1687,"url":285,"identifiers":1688},"Guay J, Choi PT, Suresh S, Albert N, Kopp S, Pace NL. Neuraxial anesthesia for the prevention of postoperative mortality and major morbidity: an overview of cochrane systematic reviews. Anesth Analg. 2014;119:716–25.",{"doi":287},{"id":1690,"text":1691,"url":1692,"identifiers":1693},"d57e7492-8494-4cd0-a9a7-f325f9ebcff2","Ballantyne JC, Kupelnick B, McPeek B, Lau J. Does the evidence support the use of spinal and epidural anesthesia for surgery? 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Can J Anesth. 2011;58:911–23.",{"doi":287},{"id":1717,"text":1718,"url":1719,"identifiers":1720},"1aa6645b-338f-45a1-a4ce-f51c59de5d48","De Kock M, Lavand’homme P, Waterloos H. ‘Balanced analgesia’ in the perioperative period: is there a place for ketamine? Pain. 2001;92:373–80.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0304395901002780",{"doi":1721},"10.1016\u002Fs0304-3959(01)00278-0",{"id":283,"text":1723,"url":285,"identifiers":1724},"Albrecht E, Kirkham KR, Liu SS, Brull R. Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis. Anaesthesia. 2013;68:79–90.",{"doi":287},{"id":18,"text":1726,"url":18,"identifiers":1727},"De Oliveira GS Jr, Castro-Alves LJ, Khan JH, McCarthy RJ. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2013;119:178–90.",{},{"id":283,"text":1729,"url":285,"identifiers":1730},"Cataldo PA, Senagore AJ, Kilbride MJ. Ketorolac and patient controlled analgesia in the treatment of postoperative pain. Surg Gynecol Obstet. 1993;176:435–8.",{"doi":287},{"id":1732,"text":1733,"url":1734,"identifiers":1735},"834c5db9-2ba3-431a-ac90-a772a055702d","Sevarino FB, Sinatra RS, Paige D, Silverman DG. Intravenous ketorolac as an adjunct to patient-controlled analgesia (PCA) for management of postgynecologic surgical pain. J Clin Anesth. 1994;6:23–7.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0952818094901139",{"doi":1736},"10.1016\u002F0952-8180(94)90113-9",{"id":283,"text":1738,"url":285,"identifiers":1739},"Vetter TR, Heiner EJ. Intravenous ketorolac as an adjuvant to pediatric patient-controlled analgesia with morphine. J Clin Anesth. 1994;6:110–3.",{"doi":287},{"id":283,"text":1741,"url":285,"identifiers":1742},"Nozadze I, Tsiklauri N, Gurtskaia G, Tsagareli MG. NSAIDs attenuate hyperalgesia induced by TRP channel activation. Data Brief. 2016;6:668–73.",{"doi":287},{"id":18,"text":1744,"url":18,"identifiers":1745},"De Oliveira Jr GS, Agarwal D, Benzon HT. Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg. 2012;114:424–33.",{},{"id":18,"text":1747,"url":18,"identifiers":1748},"Gobble RM, Hoang HL, Kachniarz B, Orgill DP. Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials. Plast Reconstr Surg. 2014;133:741–55.",{},{"id":283,"text":1750,"url":285,"identifiers":1751},"Rao W, Zhang X, Zhang J, Yan R, Hu Z, Wang Q. The role of nasogastric tube in decompression after elective colon and rectum surgery: a meta-analysis. Int J Colorectal Dis. 2011;26:423–9.",{"doi":287},{"id":283,"text":1753,"url":285,"identifiers":1754},"Hamerlynck JV, Middeldorp S. From the Cochrane Library: routine use of nasogastric tubes after abdominal surgery is not effective. Ned Tijdschr Geneeskd. 2005;149:2279–80.",{"doi":287},{"id":283,"text":1756,"url":285,"identifiers":1757},"Nelson R, Tse B, Edwards S. Systematic review of prophylactic nasogastric decompression after abdominal operations. Br J Surg. 2005;92:673–80.",{"doi":287},{"id":283,"text":1759,"url":285,"identifiers":1760},"Mackintosh C, Bowles S. Evaluation of a nurse-led acute pain service. Can clinical nurse specialists make a difference? J Adv Nurs. 1997;25:30–7.",{"doi":287},{"id":283,"text":1762,"url":285,"identifiers":1763},"Miaskowski C, Crews J, Ready LB, Paul SM, Ginsberg B. Anesthesia-based pain services improve the quality of postoperative pain management. Pain. 1999;80:23–9.",{"doi":287},{"id":283,"text":1765,"url":285,"identifiers":1766},"Bardiau FM, Taviaux NF, Albert A, Boogaerts JG, Stadler M. An intervention study to enhance postoperative pain management. Anesth Analg. 2003;96:179–85 (table of contents).",{"doi":287},{"id":1768,"text":1769,"url":1770,"identifiers":1771},"74b52c8c-8bf2-48e0-91b8-8ca41d9a885e","Stadler M, Schlander M, Braeckman M, Nguyen T, Boogaerts JG. A cost-utility and cost-effectiveness analysis of an acute pain service. J Clin Anesth. 2004;16:159–67.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0952818004000066",{"doi":1772},"10.1016\u002Fj.jclinane.2003.06.002",{"id":1774,"text":1775,"url":1776,"identifiers":1777},"2d70d6e1-430e-4dc9-8720-fe136341bbf2","Gerbershagen HJ, Rothaug J, Kalkman CJ, Meissner W. Determination of moderate-to-severe postoperative pain on the numeric rating scale: a cut-off point analysis applying four different methods. Br J Anaesth. 2011;107:619–26.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0007091217330465",{"doi":1778},"10.1093\u002Fbja\u002Faer195",{"id":283,"text":1780,"url":285,"identifiers":1781},"Aubrun F, Langeron O, Quesnel C, Coriat P, Riou B. Relationships between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration. Anesthesiology. 2003;98:1415–21.",{"doi":287},{"id":18,"text":1783,"url":18,"identifiers":1784},"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.",{},{"id":1786,"createTime":1787,"updateTime":1788,"relativeEntities":1789,"slug":1790,"properties":1791,"entityType":168,"verifyStatus":169,"verifyTime":1802,"verifyNote":171,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1803,"fullTextUrl":18,"authors":1804,"publicationType":204,"publisherRelationship":1887,"citationCount":19,"citationInfo":1938,"publishDate":1941,"publishYear":1939,"citationAnalyzeStatus":266,"lastCitationAnalyze":1942,"indexDatabases":1943,"openAccess":18,"references":18,"isForceReanalyzing":461},"2b1e9b82-5769-4b24-814f-eb85dce9855f","2024-01-09T10:08:50.848+00:00","2026-08-13T09:57:55.700+00:00",[],"Local-networks-of-community-and-healthcare-organisations-a-mixed-methods-study",{"abstract":1792,"title":1794,"gsPaper":1796,"references":1798,"doi":1800},{"EN":1793},"Local collaboration of community organisations and healthcare organisations is seen as relevant for the efficiency and efficacy of health and social care because of their potential role in providing social involvement which may reduce the need for the utilisation of formal services. Care organisations connect to each other in different ways, thus comprising an organisational network. This study aimed to describe and explore organisational networks with respect to their activities for people with diabetes mellitus type 2 and potential mechanisms of effective collaboration. Collaboration could include, for example, referring to each other and organising activities together. Potential mechanisms are navigation, negotiation and contagion. A mixed methods study was conducted in an urban and a rural area in the Netherlands. The participating organisations were mentioned by a sample of diabetes patients in these regions and by organisations’ representatives in a snowballing procedure. Next a quantitative survey and a semi-structured interview were conducted, including 35 representatives of these local organisations. The social network analysis methods was used to map and characterise the organisational networks based on results from the survey. A thematic analysis of interviews was undertaken to identify how three mechanisms (navigation, negotiation and contagion) were used in the collaboration. Both interviews and network structures showed evidence of navigation-related mechanisms. Organisations referred patients with diabetes to services within their organisation or to relevant services provided by other organisations. Hardly any negotiation or contagion-related mechanisms were identified. If negotiation between organisations was found, it seemed externally enforced. The density, centrality, and reciprocity in the networks seemed low to facilitate contagion of practices. Some organisations reported actions that could have impacted on contagion. Representatives emphasized the need of network collaboration with local or regional community and healthcare organisations. The study suggests that navigation to resources is a relevant theme in organisational networks, which could be targeted by interventions. More research is needed to explore the relevance of other network-related mechanisms.",{"EN":1795},"Local networks of community and healthcare organisations: a mixed methods study",{"VOID":1797},"[\"9647308133949220968\"]",{"VOID":1799},"Tamayo T, Rosenbauer J, Wild SH, Spijkerman AMW, Baan C, Forouhi NG, et al. Diabetes in Europe: an update. Diabetes Res Clin Pract. 2014;103(2):206–17.\nNCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387(10027):1513–30.\nLall D, Prabhakaran D. Organization of primary health care for diabetes and hypertension in high, low and middle income countries. Expert Rev Cardiovasc Ther. 2014;12(8):987–95. doi:10.1586\u002F14779072.2014.928591.\nColombo F, Llena-Nozal A, Mercier J, Tjadens F. Help wanted?: Providing and paying for long-term care. OECD Health Policy Studies, OECD Publishing. 2011. http:\u002F\u002Fwww.dx.doi.org\u002F10.1787\u002F9789264097759-en. Accessed 10 Jan 2015.\nValentijn PP, Ruwaard D, Vrijhoef HJM, de Bont A, Arends RY, Bruijnzeels MA. Collaboration processes and perceived effectiveness of integrated care projects in primary care: a longitudinal mixed-methods study. BMC Health Serv Res. 2015;15(1):1–12.\nDutch diabetes federation. Guidelines standard of care diabetes. 2016. http:\u002F\u002Fwww.zorgstandaarddiabetes.nl\u002F. Accessed 25 May 2016.\nMcDonald J, Powell Davies G, Jayasuriya R, Fort Harris M. Collaboration across private and public sector primary health care services: benefits, costs and policy implications. J Interprof Care. 2011;25(4):258–64. doi:10.3109\u002F13561820.2011.566650.\nReeves D, Blickem C, Vassilev I, Brooks H, Kennedy A, Richardson G, Rogers A. The contribution of social networks to the health and self-management of patients with long-term conditions: a longitudinal study. PLoS One. 2014;9(6):e98340.\nKoetsenruijter J, van Lieshout J, Vassilev I, Portillo MC, Serrano M, Knutsen I, et al. Social support systems as determinants of self-management and quality of life of people with diabetes across Europe: study protocol for an observational study. Health Qual Life Outcomes. 2014;. doi:10.1186\u002F1477-7525-12-29.\nMcCamish-Svensson C, Samuelsson G, Hagberg B, Svensson T, Dehlin O. Informal and formal support from a multi-disciplinary perspective: a Swedish follow-up between 80 and 82 years of age. Health Soc Care Community. 1999;7:163–76. doi:10.1046\u002Fj.1365-2524.1999.00173.x.\nKalwij A, Pasini G, Wu M. Home care for the elderly: the role of relatives, friends and neighbors. Rev Econ Househ. 2014;12(2):379–404.\nMinkman MM. Developing integrated care. Towards a development model for integrated care. Int J Integr Care. 2012;12:e197.\nNies H. Communities as co-producers in integrated care. Int J Integr Care. 2014;14:e022.\nVassilev I, Rogers A, Sanders C, Kennedy A, Blickem C, Protheroe J, et al. Social networks, social capital and chronic illness self-management: a realist review. Chronic Illn. 2011;7(1):60–86. doi:10.1177\u002F1742395310383338.\nCohen S. Social relationships and health. Am Psychol. 2004;59(8):676–84. doi:10.1037\u002F0003-066X.59.8.676.\nGucciardi E, Espin S, Morganti A, Dorado L. Exploring interprofessional collaboration during the integration of diabetes teams into primary care. BMC Fam Pract. 2016;2(17):1–14. doi:10.1186\u002Fs12875-016-0407-1.\nRaaijmakers LGM, Hamers FJM, Martens MK, Bagchus C, de Vries NK, Kremers SPJ. Perceived facilitators and barriers in diabetes care: a qualitative study among health care professionals in the Netherlands. BMC Fam Pract. 2013; 14(1):114–122. http:\u002F\u002Fwww.biomedcentral.com\u002F1471-2296\u002F14\u002F114. Accessed 25 May 2016.\nTsasis P, Evans JM, Owen S. Reframing the challenges to integrated care: a complex-adaptive systems perspective. Int J Integr Care. 2012;12:e190.\nTarrant C, Dixon-Woods M, Colman AM, Stokes T. Continuity and trust in primary care: a qualitative study informed by game theory. Ann Fam Med. 2010;8(5):440–6. doi:10.1370\u002Fafm.1160.\nFord EW, Wells R, Bailey B. Sustainable network advantages: a game theoretic approach to community-based health care coalitions. Health Care Manage Rev. 2004;29(2):159–69.\nChristakis NA, Fowler JH. Social contagion theory: examining dynamic social networks and human behavior. Stat Med. 2013;32(4):556–77.\nWensing M, van Lieshout J, Koetsenruiter J, Reeves D. Information exchange networks for chronic illness care in primary care practices: an observational study. Implement Sci. 2010;5(1):3.\nScott J, Tallia A, Crosson JC, et al. Social network analysis as an analytic tool for interaction patterns in primary care practices. Ann Fam Med. 2005;3(5):443–8. doi:10.1370\u002Fafm.344.\nBorgatti SP, Everett MG, Freeman L. UCINET for windows; Software for social network analysis. Harvard: Analytic Technologies; 2002.\nGesell SB, Barkin SL, Valente TW. Social network diagnostics: a tool for monitoring group interventions. Implement Sci. 2013;8:116. doi:10.1186\u002F1748-5908-8-116.\nWensing MJP, Eijk M, Koetsenruijter J, Bloem BR, Munneke M, Faber MJ. Connectedness of healthcare professionals involved in the treatment of patients with Parkinson’s disease: a social networks study. Implement Sci. 2011;. doi:10.1186\u002F1748-5908-6-67.\nGiven LM. The SAGE encyclopedia of qualitative research methods 2008. Thousand Oaks: SAGE Publications, Inc; 2008. doi:10.4135\u002F9781412963909.\nBurt RS. Structural holes: the social structure of competition. Cambridge: Harvard University Press; 1995.\nMorris R, Kirk S, Kennedy A, Vassilev I, Mathieson A, Jeffries M, et al. Connecting local support: a qualitative study exploring the role of voluntary organisations in long-term condition management. Chronic Illn. 2015;11:140–55.\nMossabir R, Morris R, Kennedy A, Blickem C, Rogers A. A scoping review to understand the effectiveness of linking schemes from healthcare providers to community resources to improve the health and well-being of people with long-term conditions. Health Soc Care Community. 2015;23(5):467–84. doi:10.1111\u002Fhsc.12176.\nHunter D, Perkins N. Partnership working in public health: the implications for governance of a systems approach. J Health Serv Res Policy. 2012;17(Suppl 2):45–52. doi:10.1258\u002Fjhsrp.2012.011127.\nChambers D, Wilson P, Thompson C, Harden M. Social network analysis in healthcare settings: a systematic scoping review. PLoS One. 2012;7(8):e41911. doi:10.1371\u002Fjournal.pone.0041911.\nKroneman M, Cardol M, Friele R. Review: (De)centralization of social support in six Western European countries. Health Policy. 2012;106:76–87.\nLaumann EO, Marsden PV, Prensky D. The boundary specification problem in network analysis. Res Methods Soc Netw Anal. 1989;61:87.\nKennedy A, Rogers A, Vassilev I, Todorova E, Roukova P, Foss C, et al. Dynamics and nature of support in the personal networks of people with type 2 diabetes living in Europe: qualitative analysis of network properties. Health Expect. 2015;18(6):3172–85. doi:10.1111\u002Fhex.12306.\nDunn AG, Westbrook JI. Interpreting social network metrics in healthcare organisations: a review and guide to validating small networks. Soc Sci Med. 2011;72(7):1064–8.",{"VOID":1801},"10.1186\u002Fs13104-016-2135-y","2024-06-25T15:39:26.389+00:00","https:\u002F\u002Fbmcresnotes.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13104-016-2135-y",[1805,1822,1837,1854,1874],{"id":1806,"sortIndex":19,"researcher":18,"roles":1807,"affiliations":1808,"properties":1817,"displayName":1819,"givenName":18,"familyName":18},"f58ba80b-f6cf-471b-a83c-f64977f6e5bf",[177],[1809],{"id":1810,"sortIndex":19,"affiliation":1811,"properties":18},"b00dfdf0-3463-47ad-9ee6-f4ae136068d4",{"id":1810,"createTime":18,"updateTime":18,"relativeEntities":1812,"slug":18,"properties":1813,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1816,"statistic":18},[],{"title":1814},{"VI":1815},"Faculty of Health and Social Studies, HAN University of Applied Sciences, Nijmegen, The Netherlands",[],{"title":1818,"gsAuthor":1820},{"VI":1819},"Wendy Kemper-Koebrugge",{"VOID":1821},"[\"kec_LzQAAAAJ\"]",{"id":1823,"sortIndex":192,"researcher":18,"roles":1824,"affiliations":1825,"properties":1834,"displayName":1836,"givenName":18,"familyName":18},"ac210838-2dbe-477c-8ead-ab400ebdbbd1",[177],[1826],{"id":1827,"sortIndex":19,"affiliation":1828,"properties":18},"7d4b3695-9daf-45ba-8f98-6535080f57b1",{"id":1827,"createTime":18,"updateTime":18,"relativeEntities":1829,"slug":18,"properties":1830,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1833,"statistic":18},[],{"title":1831},{"VI":1832},"Radboud Institute for Health Sciences, IQ Healthcare Nijmegen, The Netherlands114-IQ Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands",[],{"title":1835},{"VI":1836},"Jan Koetsenruijter",{"id":1838,"sortIndex":262,"researcher":18,"roles":1839,"affiliations":1840,"properties":1849,"displayName":1851,"givenName":18,"familyName":18},"a00ac4a0-54ad-4b7e-8db0-6b1a4e72ac66",[177],[1841],{"id":1842,"sortIndex":19,"affiliation":1843,"properties":18},"1ffe0a24-009d-4407-90eb-1aa82645cf1e",{"id":1842,"createTime":18,"updateTime":18,"relativeEntities":1844,"slug":18,"properties":1845,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1848,"statistic":18},[],{"title":1846},{"EN":1847},"Faculty of Health Sciences, NIHR CLAHRC Wessex, University of Southampton, Southampton, UK",[],{"title":1850,"gsAuthor":1852},{"VI":1851},"Anne Rogers",{"VOID":1853},"[\"-DVCCLQAAAAJ\"]",{"id":1855,"sortIndex":261,"researcher":18,"roles":1856,"affiliations":1857,"properties":1871,"displayName":1873,"givenName":18,"familyName":18},"2f8ea370-6ccc-481c-909c-5a9d468dcdfe",[177],[1858,1864],{"id":1810,"sortIndex":19,"affiliation":1859,"properties":18},{"id":1810,"createTime":18,"updateTime":18,"relativeEntities":1860,"slug":18,"properties":1861,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1863,"statistic":18},[],{"title":1862},{"VI":1815},[],{"id":1827,"sortIndex":192,"affiliation":1865,"properties":1870},{"id":1827,"createTime":18,"updateTime":18,"relativeEntities":1866,"slug":18,"properties":1867,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1869,"statistic":18},[],{"title":1868},{"VI":1832},[],{},{"title":1872},{"VI":1873},"Miranda 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main objective of this study was to determine the serological prevalence of brucellosis on a dairy farm with no past history of abortions, but where Brucella control measures including test and slaughter and vaccination of heifers at 4–8 months of age was practiced. Secondary data from 2011 to 2014 obtained from the Epidemiology Section of the Directorate of Veterinary Services was used. Mandatory annual brucellosis testing results for mature dairy cows on a dairy farm for the period 2011–2014 were collated and analyzed. Results of a total of 6912 cows were analysed. The data comprised of the year of testing, number of cows tested for Brucella antibodies and the number of cows that tested positive. Serological testing was carried out using the Rose Bengal Test (RBT) as a screening test and the Complement Fixation Test as a confirmatory test for results that tested positive on the RBPT. Over the 4-year period, one dairy cow tested positive for Brucella antibodies in 2013 giving an apparent prevalence of 0.05% and an overall prevalence of 0.01%. When apparent prevalence was adjusted for RBPT test specificity and sensitivity of 71 and 78% respectively, true prevalence was determined to be zero.",{"EN":1954},"Serological prevalence and public health significance of brucellosis on a dairy farm in Namibia from 2011 to 2014",{"VOID":1956},"[\"16027579939735714888\"]",{"VOID":1958},"Mugizi DR, Boqvist S, Nasinyama GW, Waiswa C, Ikwap K, Rock K, Lindali E, Magnusson U, Frume J. Prevalence of the factors associated with Brucella sero-positivity in cattle in urban and peri-urban Gulu and Soroti towns of Uganda. J Vet Med Sci. 2015;77:557–64.\nMangen MJ, Otte J, Pfeiffer D, Chilonda P. Bovine brucellosis in sub-Saharan Africa: estimation of sero-prevalence and impact on meat and milk off-take potential. 2002. http:\u002F\u002Fwww.fao.org\u002F3\u002Fa-ag274e.pdf. Accessed 5 Apr 2016.\nSeleem MN, Boyle SM, Sriranganathan N. Brucellosis: a reemerging zoonosis. Vet Microbiol. 2010;140:392–8.\nGodfroid J, Garin-Bastuji B, Blasco JM, Thomson J, Thoen CO. Brucella melitensis infection. In: Coetzer JAW, Thomson GR, Tustin RC, editors. Infectious diseases of livestock. Cape Town: Oxford University Press; 2004. p. 1535–41.\nGodfroid J, Nielsen K, Saegerman C. Diagnosis of brucellosis in livestock and wildlife. Croat Med J. 2010;51:296–305.\nIbarra V, Blanco JR, Metola L, Oteo A. Relapsing brucellosis in a patient infected with the Immunodeficiency Virus (HIV). J Clin Microb Infect. 2003;9:12.\nMagwedere K, Bishi A, Tjipura-Zaire G, Eberle G, Hemberger Y, Hoffman LC, Dziva F. Brucellae through the food chain: the role of sheep, goats and springbok (Antidorcus marsupialis) as sources of human infection in Namibia. J S Afr Vet Assoc. 2011;82:205–12.\nMadzingira O, McCrindle CME. Prevalence of Brucella antibodies in sheep and springbok (Antidorcas marsupialis) reared together in the Karas region, Namibia. Bull Anim Health Prod Afr. 2014;62:299–306.\nMadzingira O, McCrindle CME. Retrospective analysis of the prevalence of Brucella antibodies in sheep in the Karas Region of Namibia. Trop Anim Health Prod. 2015;47:1117.\nMadzingira O, McCrindle CME. A questionnaire survey of risk factors of brucellosis on mixed sheep and springbok (Antidorcas marsupialis) farms. Int Sci Technol J Namibia. 2016;8:43–9.\nDepner K. Brucellosis in domestic ruminants, game and man in Namibia: a serosurvey using different diagnostic methods. 1993. http:\u002F\u002Felib.tiho-hannover.de\u002Fdissertations\u002F93depner-k.pdf. Accessed 20 June 2010.\nManual OIE. Manual of diagnostic tests and vaccines for terrestrial animals. Paris: Office International Des Epizooties; 2004.\nChisi SL, Marageni Y, Naidoo P, Zulu G, Akol GW, van Heerden H. An evaluation of serological tests in the diagnosis of bovine brucellosis in naturally infected cattle in KwaZulu-Natal province in South Africa. J S Afr Vet Assoc. 2017;88:a1381. https:\u002F\u002Fdoi.org\u002F10.4102\u002Fjsava.v88i0.1381.\nReiczigel J, Földi J, Ózsvári L. Exact confidence limits for prevalence of a disease with an imperfect diagnostic test. Epid Infect. 2010;138:1674–8.\nBercovich Z. Maintenance of Brucella abortus free herds: a review with emphasis on epidemiology and the problems of diagnosing brucellosis in areas of low prevalence. Vet Quart. 1998;20:81–8.\nNielsen K, Smith P, Yu W, Nicoletti P, Jungersen G, Stack J, Godfroid J. Serological discrimination by enzyme immunoassay between the antibody response to Brucella sp. and Yersinia enterecolitica O:9 in cattle and pigs. Vet Immun Immunopathol. 2006;109:69–78.\nOie A. Manual of diagnostic tests and vaccines for terrestrial animals. Paris: Office international des epizooties; 2008. p. 1092–106.\nFAO. Brucellosis in humans and animals. Rome: Food and Agriculture Organisation; 2006.\nRekha VB, Gunaseelan L, Subramanian A, Yale G. A study on bovine brucellosis in an organized dairy farm. Vet World. 2013;6:681–5.\nSacchia M, Di Provvido A, Ippoliti C, Kefle U, Sebhatu TTD, Angelo A, De Massis F. Prevalence of brucellosis in dairy farming regions of eritrea. Onderstepoort J Vet Res. 2013;80:4.\nAbdullah AH, Bashir UM, Rafiqul IM, Cho H-S, Mukter HM. Serological prevalence of brucellosis of cattle in selected dairy farms in Bangladesh. Korean J Vet Res. 2014;54:239–43.\nAsgedon H, Damena D, Duguma R. Seroprevalence of bovine brucellosis and associated risk factors in and around Alage district, Ethiopia. SpringerPlus. 2016;5:851. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs40064-016-2547-0.\nGeresu MA, Ameni G, Kassa T, Tuli G, Arenas A, Kassa GM. Seropositivity and risk factors for Brucella in dairy cows in Asella and Bishoftu towns, Oromia Regional State, Ethiopia. Afr J Microbiol Res. 2016;10:203–13.\nTesfaye G, Tsegaye W, Chanie M, Abinet F. Seroprevalence and associated risk factors of bovine brucellosis in Addis Ababa dairy farms. Trop Anim Health Prod. 2011;43:1001–5.\nTschopp R, Abera B, Sourou SY, Guerne-Bleich E, Aseffa A, Wubete A, Zinsstag J, Young D. Bovine tuberculosis and bruellosis prevalence in cattle from selected milk cooperatives in Arsi zone, Oromia region, Ethiopia. BMC Vet Res. 2013. https:\u002F\u002Fdoi.org\u002F10.1186\u002F1746-6148-9-163.\nAsmare K, Sibhat B, Molla W, Ayelet G, Shiferaw J, Martin AD, Skjerve E, Godfroid J. The status of bovine brucellosis in Ethiopia with special emphasis on exotic and cross bred cattle in dairy and breeding farms. Acta Trop. 2013;126:186–92.\nBishop GC, Bosman PP, Herr S. Bovine brucellosis. In: Coetzer JAW, Thomson GR, Tustin RC, editors. Infectious diseases of livestock with special reference to Southern Africa. Cape Town: Oxford University Press; 1994. p. 1053–66.\nJeff A. Brucellosis diagnostics. Wyoming: Wyoming State University; 2003.\nFAO. Brucella melitensis in Eurasia and the Middle East. Rome: FAO Animal Production and Health Proceedings. No. 10; 2010.\nMatope G, Bhebhe E, Muma JB, Oloya J, Madekurozwa RL, Lund A, Skjerve E. Seroprevalence of brucellosis and its associated risk factors in cattle from small holder dairy farms in Zimbabwe. Trop Anim Health Prod. 2011;43:975–82.\nMai HM, Irons PC, Kabir J, Thompson PN. A large seroprevalence survey of brucellosis in cattle herds under diverse production systems in northern Nigeria. BMC Vet Res. 2012;8:144.\nNicoletti P. The eradication of brucellosis in animals. Saudi Med J. 1993;14:288–92.\nFAO. Guidelines for coordinated animal and human brucellosis surveillance. Rome: FAO Animal Production and Health Paper 156; 2010.",{"VOID":1960},"10.1186\u002Fs13104-017-2933-x","2024-06-24T18:18:33.721+00:00","https:\u002F\u002Fbmcresnotes.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13104-017-2933-x",[1964,1981],{"id":1965,"sortIndex":19,"researcher":18,"roles":1966,"affiliations":1967,"properties":1976,"displayName":1978,"givenName":18,"familyName":18},"95f7bd34-7279-4df0-85de-a736d81371d8",[177],[1968],{"id":1969,"sortIndex":19,"affiliation":1970,"properties":18},"df3c6835-faf5-4d99-a01d-4850916f1516",{"id":1969,"createTime":18,"updateTime":18,"relativeEntities":1971,"slug":18,"properties":1972,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1975,"statistic":18},[],{"title":1973},{"VI":1974},"Department of Animal Health, University of Namibia, Ngweze, Namibia",[],{"title":1977,"gsAuthor":1979},{"VI":1978},"Oscar 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is considered the standard therapy for advanced human epidermal growth factor receptor 2 (HER2)-positive gastric cancer with mild manageable toxicity, on the basis of the results of a pivotal phase-III trial. Cerebrovascular events are not recognized as expected adverse effects of such therapy. We report the case of a 67-year-old, current-smoking male with stage-IV HER2-positive gastric cancer who suffered right middle cerebral artery (MCA) embolism after trastuzumab + chemotherapy. He received trastuzumab and cisplatin on Day 1, followed by a continuous 5-fluorouracil infusion for 5 days as a first-line treatment. Four days after chemotherapy initiation, he presented with left hemiplegia, and brain magnetic resonance imaging and magnetic resonance angiography revealed a right MCA occlusion. No further chemotherapy was administered because of worsening performance status. The present case, possibly the first such reported case, suggests the risk of development of embolism after trastuzumab + chemotherapy in HER2-positive advanced gastric cancer, although other factors should be considered.",{"EN":2060},"A case of severe cerebral embolism after chemotherapy for HER2-positive gastric cancer",{"VOID":2062},"[\"9854291977175529568\"]",{"VOID":2064},"10.1186\u002Fs13104-015-1059-2","2024-04-27T08:27:32.640+00:00","https:\u002F\u002Fbmcresnotes.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13104-015-1059-2",[2068,2085,2098,2111],{"id":2069,"sortIndex":19,"researcher":18,"roles":2070,"affiliations":2071,"properties":2080,"displayName":2082,"givenName":18,"familyName":18},"df779c5c-3390-4eca-9bc3-cdb4081d24c2",[177],[2072],{"id":2073,"sortIndex":19,"affiliation":2074,"properties":18},"7aac4b90-0ab9-4f21-a20c-82ec38027bcd",{"id":2073,"createTime":18,"updateTime":18,"relativeEntities":2075,"slug":18,"properties":2076,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2079,"statistic":18},[],{"title":2077},{"VI":2078},"Department of Medical Oncology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan",[],{"title":2081,"gsAuthor":2083},{"VI":2082},"Takayuki 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YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376:687–7.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS014067361061121X",{"doi":2186},"10.1016\u002Fs0140-6736(10)61121-x",{"id":18,"text":2188,"url":18,"identifiers":2189},"Al-Thenayan E, Maghfoor I. Complications of malignancy: case 1. Systemic tumor embolism from lung cancer at presentation. J Clin Oncol. 2004;22:372–3.",{},{"id":283,"text":2191,"url":285,"identifiers":2192},"Blom JW, Doggen CJ, Osanto S, Rosendaal FR. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA. 2005;293:715–22.",{"doi":287},{"id":18,"text":2194,"url":18,"identifiers":2195},"Mannami T, Iso H, Baba S, Sasaki S, Okada K, Konishi M, et al. Cigarette smoking and risk of stroke and its subtypes among middle-aged Japanese men and women: the JPHC Study Cohort I. Stroke. 2004;35:1248–53.",{},{"id":283,"text":2197,"url":285,"identifiers":2198},"Li SH, Chen WH, Tang Y, Rau KM, Chen YY, Huang TL, et al. Incidence of ischemic stroke post-chemotherapy: a retrospective review of 10,963 patients. Clin Neurol Neurosurg. 2006;108:150–6.",{"doi":287},{"id":283,"text":2200,"url":285,"identifiers":2201},"Cardinale D, Sandri MT, Martinoni A, Tricca A, Civelli M, Lamantia G, et al. Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy. J Am Coll Cardiol. 2000;36:517–22.",{"doi":287},{"id":283,"text":2203,"url":285,"identifiers":2204},"Cardinale D, Sandri MT, Colombo A, Colombo N, Boeri M, Lamantia G, et al. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation. 2004;109:2749–54.",{"doi":287},{"id":283,"text":2206,"url":285,"identifiers":2207},"Cardinale D, Colombo A, Torrisi R, Sandri MT, Civelli M, Salvatici M, et al. Trastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin I evaluation. J Clin Oncol. 2010;28:3910–6.",{"doi":287},{"id":2209,"createTime":2210,"updateTime":2211,"relativeEntities":2212,"slug":2213,"properties":2214,"entityType":168,"verifyStatus":169,"verifyTime":2223,"verifyNote":171,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":2224,"fullTextUrl":18,"authors":2225,"publicationType":204,"publisherRelationship":2336,"citationCount":19,"citationInfo":2387,"publishDate":2390,"publishYear":2388,"citationAnalyzeStatus":2391,"lastCitationAnalyze":2392,"indexDatabases":2393,"openAccess":18,"references":2394,"isForceReanalyzing":461},"874f4ee0-437f-46d6-8009-7a5a6193616f","2024-01-07T16:53:37.177+00:00","2026-07-28T12:14:17.012+00:00",[],"Gene-profiling-of-human-VEGF-signaling-pathways-in-human-endothelial-and-retinal-pigment-epithelial-cells-after-anti-VEGF-treatment",{"abstract":2215,"title":2217,"gsPaper":2219,"doi":2221},{"EN":2216},"Ranibizumab (Lucentis®) is a Fab-antibody fragment developed from Bevacizumab, a full-length anti-VEGF antibody. Both compounds are used for treating age-related macular degeneration (AMD). The influence of bevacizumab and ranibizumab on genes involved in signal transduction and cell signaling downstream of VEGF were compared in order to detect possible differences in their mode of action, which are not related to their Fab-antibody fragments. Human umbilical vein cell lines (EA.hy926) and retinal pigment epithelial cells (ARP-19) were exposed to oxidative stress. The cells were treated with therapeutic concentrations of bevacizumab (0.25 mg\u002FmL) and ranibizumab (125 mg\u002FmL) for 24 hours prior to all experiments, and their effects on gene expressions were determined by RT- PCR. After exposure to bevacizumab, more genes in the endothelial cells were up-regulated (KDR, NFATc2) and down-regulated (Pla2g12a, Rac2, HgdC, PRKCG) compared to non-treated controls. After exposure to ranibizumab, fewer genes were up-regulated (PTGS2) and down-regulated (NOS3) compared to controls. In comparison between drugs, more genes were up-regulated (NFATc2 and KDR) and more were down-regulated (Pla2g12a, Pla2g1b, Ppp3r2, Rac2) by bevacizumab than by ranibizumab. In RPE cells, NOS3 and PGF were up-regulated and Pla2g12b was down-regulated after exposure to ranibizumab, while PIK3CG was up-regulated and FIGF was down-regulated after exposure to bevacizumab, but the differences in gene expression were minor between drugs (PIK3CGand PGF were down-regulated more by ranibizumab than by bevacizumab). The different gene expressions after exposure to ranibizumab and bevacizumab in endothelial and RPE cells may indicate a somewhat different biological activity of the two compounds.",{"EN":2218},"Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF 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F, Das B: Anti-angiogenic effects of ribonucleic acid interference targeting vascular endothelial growth factor and hypoxia- inducible factor-1alpha. 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Ophthalmology. 2006, 113: 363-372. e365",{"doi":287},{"id":18,"text":2420,"url":18,"identifiers":2421},"Moreno SF, Paloma JB: Therapeutic anti-VEGF in age-related macular degeneration: Ranibizumab and Bevacizumab controversy. Br J Ophthalmol. 2008, 92: 866-867.",{},{"id":283,"text":2423,"url":285,"identifiers":2424},"Klettner A, Roider J: Comparison ofbevacizumab, ranibizumab, and pegaptanib in vitro: Efficiency and possible additional pathways. Invest Ophthalmol Vis Sci. 2008, 49: 4523-4527.",{"doi":287},{"id":18,"text":2426,"url":18,"identifiers":2427},"Spitzer MS, Wallenfels-Thilo B, Sierra A, Yoeruek E, Peters S, Henke-Fahle S, Bartz-Schmidt KU, Szurman P, Tuebingen Bevacizumab Study Group: Antiproliferative and cytotoxic properties of bevacizumab on different ocular cells. Br J Ophthalmol. 2006, 90: 1316-1321.",{},{"id":283,"text":2429,"url":285,"identifiers":2430},"Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ, CATT Research Group: Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011, 364: 1897-1908.",{"doi":287},{"id":18,"text":2432,"url":18,"identifiers":2433},"Chakravarthy U, Harding SP, Rogers CA, Downes SM, Lotery AJ, Wordsworth S, Reeves BC, IVAN Study Investigators: Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. Ophthalmology. 2012, 119 (7): 1399-1411.",{},{"id":283,"text":2435,"url":285,"identifiers":2436},"Fernando NH, Hurwitz HI: Targeted therapy of colorectal cancer: clinical experience with bevacizumab. 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J Biol Chem. 1997, 272: 10678-10684.",{"doi":287},{"id":18,"text":2451,"url":18,"identifiers":2452},"Ferrara N, Damico L, Shams N, Lowman H, Kim R: Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006, 26: 859-870.",{},{"id":283,"text":2454,"url":285,"identifiers":2455},"Meyer CH, Holzl FG: Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab. Eye (Lond). 2011, 25 (6): 661-672.",{"doi":287},{"id":2457,"text":2458,"url":2459,"identifiers":2460},"89e63839-7679-4ed6-9fab-c60cb22a05fd","Klettner A, Möhle F, Roider J: Intracellular bevacizumab reduces phagocytotic uptake in RPE cells. 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Br J Ophthalmol. 2012, 96 (7): 1023-1028.",{"doi":287},{"id":283,"text":2472,"url":285,"identifiers":2473},"Bian ZM, Elner SG, Elner VM: Regulation of VEGF mRNA expression and protein secretion by TGF-beta2 in human retinal pigment epithelial cells. Exp Eye Res. 2007, 84: 812-822.",{"doi":287},{"id":283,"text":2475,"url":285,"identifiers":2476},"Kunchithapautham K, Rohrer B: Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem. 2011, 286: 23717-23724.",{"doi":287},{"id":18,"text":2478,"url":2479,"identifiers":2480},"SAB biosciences RT [2] Profiler PCR Array assay (Qiagen).http:\u002F\u002Fwww.sabiosciences.com\u002Frt_pcr_product\u002FHTML\u002FPAHS-091A.html,","http:\u002F\u002Fwww.sabiosciences.com\u002Frt_pcr_product\u002FHTML\u002FPAHS-091A.html",{},{"id":283,"text":2482,"url":285,"identifiers":2483},"Perotti V, Baldassari P, Bersani I, Molla A, Vegetti C, Tassi E, Dal Col J, Dolcetti R, Anichini A, Mortarini R: NFATc2 is a potential therapeutic target in human melanoma. J Invest Dermatol. 2012, 132 (11): 2652-2660.",{"doi":287},{"id":283,"text":2485,"url":285,"identifiers":2486},"Endo A, Nagashima K, Kurose H, Mochizuki S, Matsuda M, Mochizuki N: Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. J Biol Chem. 2002, 277: 23747-23754.",{"doi":287},{"id":18,"text":2488,"url":18,"identifiers":2489},"Matsumoto T, Claesson-Welsh L: VEGF receptor signal transduction. Sci STKE. 2001, RE 21",{},{"id":283,"text":2491,"url":285,"identifiers":2492},"Chae JK, Kim I, Lim ST, Chung MJ, Kim WH, Kim HG, Ko JK, Koy GY: Co administration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization. Arterioscler Thromb Vasc Biol. 2000, 20: 2573-2578.",{"doi":287},{"id":283,"text":2494,"url":285,"identifiers":2495},"Saint-Geniez M, Maharaj ASR, Walshe TE, Tucker BA, Sekiyama E, Kurihara T, Darland DC, Young MJ, D’Amore PA: Endogenous VEGF is required for visual function: Evidence for a survival role on Müller cells and photoreceptors. PLoS One. 2008, 3: e3554-",{"doi":287},{"id":18,"text":2497,"url":18,"identifiers":2498},"Klettner A, Westhues D, Lassen J, Bartsch S, Roider J: Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium\u002Fchoroid organ cultures: p38, nuclear factor kappaB, and the vascular endothelial growth factor receptor-2\u002Fphosphatidylinositol 3 kinase pathway. Mol Vis. 2013, 19: 281-291.",{},{"id":283,"text":2500,"url":285,"identifiers":2501},"Adamis AP, Shima DT, Tolentino MJ, Gragoudas ES, Ferrara N, Folkman J, D'Amore PA, Miller JW: Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol. 1996, 114: 66-71.",{"doi":287},{"id":283,"text":2503,"url":285,"identifiers":2504},"Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michauda NA, Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michauda NA, Li W, Connolly E, O'Neill CA, Miller JW: Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 2002, 120: 338-346.",{"doi":287},{"id":283,"text":2506,"url":285,"identifiers":2507},"Rakic JM, Lambert V, Devy L, Luttun A, Carmeliet P, Claes C, Nguyen L, Foidart JM, Noël A, Munaut C: Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003, 44: 3186-3193.",{"doi":287},{"id":283,"text":2509,"url":285,"identifiers":2510},"Wells JA, Murthy R, Chibber R, Nunn A, Molinatti PA, Kohner EM, Gregor ZJ: Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinalneovascularisation. Br J Ophthalmol. 1996, 80: 363-366.",{"doi":287},{"id":283,"text":2512,"url":285,"identifiers":2513},"Adamis AP, Miller JW, Bernal MT, D’Amico DJ, Folkman J, Yeo TK, Yeo KT: Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994, 118: 445-450.",{"doi":287},{"id":2515,"createTime":2516,"updateTime":2517,"relativeEntities":2518,"slug":2519,"properties":2520,"entityType":168,"verifyStatus":169,"verifyTime":2531,"verifyNote":171,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":2532,"fullTextUrl":18,"authors":2533,"publicationType":204,"publisherRelationship":2652,"citationCount":2701,"citationInfo":2702,"publishDate":2704,"publishYear":2176,"citationAnalyzeStatus":2391,"lastCitationAnalyze":2517,"indexDatabases":2705,"openAccess":18,"references":18,"isForceReanalyzing":461},"dfadc880-fe63-4d1e-80e3-981c8f26ad23","2024-01-17T04:44:19.916+00:00","2026-07-27T16:55:56.795+00:00",[],"Estimation-of-acute-and-chronic-Q-fever-incidence-in-children-during-a-three-year-outbreak-in-the-Netherlands-and-a-comparison-with-international-literature",{"abstract":2521,"title":2523,"gsPaper":2525,"references":2527,"doi":2529},{"EN":2522},"In the Dutch 2007–2009 Q fever outbreak Coxiella burnetii was transmitted aerogenically from dairy goat farms to those living in the surrounding areas. Relatively few children were reported. The true number of pediatric infections is unknown. In this study, we estimate the expected number of acute and chronic childhood infections. As Coxiella was transmitted aerogenic to those living near infected dairy goat farms, we could use adult seroprevalence data to estimate infection risk for inhabitants, children and\n adults alike. Using Statistics Netherlands data we estimated the number of children at (high) risk for developing chronic Q fever. Literature was reviewed for childhood (0–15 years) Q fever reports and disease rates. We compared this with Dutch reported and our estimated data for 2007–2009. In The Netherlands epidemic, 44 children were reported (1.2 % of total notifications). The childhood incidence was 0.15 compared to 2.6 per 10,000 inhabitants for adults. No complications were reported. Based on the expected similarity in childhood and adult exposure we assume that 9.8 % of children in the high-risk area had Q fever infection, resulting\n in 1562 acute infections during the Q fever epidemic interval. Based on the prevalence of congenital heart disease, at least 13 children are at high risk for developing chronic Q fever. In medical literature, 42 case reports described 140 childhood Q fever cases with a serious outcome (four deaths). In chronic Q fever, cardiac infections were predominant. Four outbreaks were reported involving children, describing 11 childhood cases. 36 National and\u002For regional studies reported seroprevalences varying between 0 and 70 %. In the 3-year Dutch epidemic, few childhood cases were reported, with pulmonary symptoms leading, and none with a serious presentation. With an estimated 13 high-risk children for chronic infection in the high exposure area, and probably forty in the whole country, we may expect several chronic Q fever complications in the coming years in paediatric practice.",{"EN":2524},"Estimation of acute and chronic Q fever incidence in children during a three-year outbreak in the Netherlands and a comparison with international literature",{"VOID":2526},"[\"16779395786076436265\"]",{"VOID":2528},"Dijkstra F, et al. The 2007–2010 Q fever epidemic in The Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming. FEMS Immunol Med Microbiol. 2012;64(1):3–12.\nBart IY, et al. Pediatric acute Q fever mimics other common childhood illnesses. PLoS One. 2014;9(2):e88677.\nCommandeur M, Jeurissen L, van der Hoek W, Roest HJ, Hermans TC. Spatial relationships in the Q fever outbreaks 2007–2010 in the Netherlands. Int J Environ Health Res. 2014;24(2):137–57.\nSchimmer B, et al. The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak. BMC Infect Dis. 2010;10:69.\nvan der Hoek W, et al. Smooth incidence maps give valuable insight into Q fever outbreaks in The Netherlands. Geospat Health. 2012;7(1):127–34.\nRoest HI, et al. The Q fever epidemic in The Netherlands: history, onset, response and reflection. Epidemiol Infect. 2011;139(1):1–12.\nDupuis G, et al. Clinical aspects observed during an epidemic of 415 cases of Q fever. Schweiz Med Wochenschr. 1985;115(24):814–8.\nMaltezou HC, Raoult D. Q fever in children. Lancet Infect Dis. 2002;2(11):686–91.\nParker NR, Barralet JH, Bell AM. Q fever. Lancet. 2006;367(9511):679–88.\nRaoult D, Marrie T, Mege J. Natural history and pathophysiology of Q fever. Lancet Infect Dis. 2005;5(4):219–26.\nDerrick EH. “Q” fever, a new fever entity: clinical features, diagnosis and laboratory investigations. Med J Aust. 1937;II:281–99.\nFenollar F, et al. Risks factors and prevention of Q fever endocarditis. Clin Infect Dis. 2001;33(3):312–6.\nLandais C, et al. From acute Q fever to endocarditis: serological follow-up strategy. Clin Infect Dis. 2007;44(10):1337–40.\nRaoult D, et al. Q fever 1985–1998. Clinical and epidemiologic features of 1383 infections. Medicine (Baltimore). 2000;79(2):109–23.\nNotermans DW, et al. [Sero-epidemiology of Q fever in the Netherlands in 2006–2007] (Sero-epidemiologie van Q-koorts in Nederland in 2006–2007). Infectieziekten Bull. 2010;21(9):314–6.\nHogema BM, et al. Coxiella burnetii infection among blood donors during the 2009 Q-fever outbreak in The Netherlands. Transfusion. 2012;52(1):144–50.\nStatistics Netherlands CBS. Population pyramid. http:\u002F\u002Fwww.cbs.nl\u002Fen-GB\u002Fmenu\u002Fthemas\u002Fbevolking\u002Fcijfers\u002Fextra\u002Fpiramide-fx.htm. Accessed 2011.\nHealth-Council-of-the-Netherlands. Human vaccination against Q fever. The Hague: Health Council of the Netherlands; 2010 (publication no. 2010\u002F08E. ISBN 978-90-5549-809-3).\nRIVM. Numbers of congenital defects of the heart and\u002For vessels (prevalence and death) of the VTV 2010. National Compass Public Health. (Cijfers aangeboren afwijkingen van het hartvaatstelsel (prevalentie en sterfte) uit de VTV 2010. Nationaal Kompas Volksgezondheid, versie 4.1.1, 11 November 2010, © RIVM, Bilthoven). http:\u002F\u002Fwww.nationaalkompas.nl\u002Fgezondheid-en-ziekte\u002Fziekten-en-aandoeningen\u002Faangeboren-afwijkingen\u002Fhartvaatstelsel\u002Fcijfers-aangeboren-afwijkingen-van-het-hartvaatstelsel-prevalentie-en-sterfte-uit-de-vtv-2010\u002F. Accessed 2011).\nRIVM\u002FEPI. Reported Q fever patients. http:\u002F\u002Fwww.zorgatlas.nl\u002Fgezondheid-en-ziekte\u002Fziekten-en-aandoeningen\u002Finfectieziekten\u002Fgemelde-q-koortspatienten\u002F#breadcrumb. Accessed 2011.\nSchimmer B, et al. Low seroprevalence of Q fever in The Netherlands prior to a series of large outbreaks. Epidemiol Infect. 2012;140(1):27–35.\nRegistration Network General Practices. 2013. http:\u002F\u002Fwww.nationaalkompas.nl\u002Falgemeen\u002Fmeta-informatie\u002Fbronbeschrijvingen\u002Fregistratienet-huisartsenpraktijken-rnh\u002F. Accessed 2011).\nCMR-Nijmegen, Continuous Morbidity Registration Nijmegen. http:\u002F\u002Fwww.umcn.nl\u002FResearch\u002FDepartments\u002Feerstelijnsgeneeskunde\u002FPages\u002FExpertisegroepMIMS.aspx. Accessed 2011.\nEurocat. Actual numbers of congenital anomalies. http:\u002F\u002Fwww.rug.nl\u002Fresearch\u002Fgenetics\u002Feurocat\u002F. Accessed 2011.\nRIVM-National-Compass-Public-Health. Congenital disorders of the heart and vessels: prevalence and death according to age and gender. http:\u002F\u002Fwww.nationaalkompas.nl\u002Fgezondheid-en-ziekte\u002Fziekten-en-aandoeningen\u002Faangeboren-afwijkingen\u002Fhartvaatstelsel\u002Fcijfers-aangeboren-afwijkingen-van-het-hartvaatstelsel-prevalentie-en-sterfte-uit-de-vtv-2010\u002F. Accessed 15 Nov 2012.\nAmitai Z, et al. A large Q fever outbreak in an urban school in central Israel. Clin Infect Dis. 2010;50(11):1433–8.\nCosta PS, Brigatte ME, Greco DB. Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil. Rev Inst Med Trop Sao Paulo. 2006;48(1):5–9.\nJorm LR, Lightfoot NF, Morgan KL. An epidemiological study of an outbreak of Q fever in a secondary school. Epidemiol Infect. 1990;104(3):467–77.\nPorten K, et al. A super-spreading ewe infects hundreds with Q fever at a farmers’ market in Germany. BMC Infect Dis. 2006;6:147.\nRobert-Koch-Institut, (Hrsg), and Berlin. Ermittlungen zu einem Q-Fieber-Ausbruch in einer Großfamilie. Epidemiol Bull. 2004;24:205–7.\nJulvez J, Michault A, Kerdelhue C. Serological study of rickettsia infections in Niamey, Niger. Med Trop (Mars). 1997;57(2):153–6.\nKobbe R, et al. Q fever in young children, Ghana. Emerg Infect Dis. 2008;14(2):344–6.\nMediannikov O, et al. Coxiella burnetii in humans and ticks in rural Senegal. PLoS Negl Trop Dis. 2010;4(4):e654.\nOkabayashi T, et al. Short report: prevalence of antibodies against spotted fever, murine typhus, and Q fever rickettsiae in humans living in Zambia. Am J Trop Med Hyg. 1999;61(1):70–2.\nSteinmann P, et al. Seroprevalence of Q-fever in febrile individuals in Mali. Trop Med Int Health. 2005;10(6):612–7.\nLacheheb A, Raoult D. Seroprevalence of Q-fever in Algeria. Clin Microbiol Infect. 2009;15(Suppl 2):167–8.\nDupont HT, et al. Prevalence of antibodies to Coxiella burnetti, Rickettsia conorii, and Rickettsia typhi in seven African countries. Clin Infect Dis. 1995;21(5):1126–33.\nHirai K, To H. Advances in the understanding of Coxiella burnetii infection in Japan. J Vet Med Sci. 1998;60(7):781–90.\nNagaoka H, et al. Isolation of Coxiella burnetii from children with influenza-like symptoms in Japan. Microbiol Immunol. 1996;40(2):147–51.\nPorter SR, Czaplicki G, Mainil J, Horii Y, Misawa N, Saegerman C. Q fever in Japan: an update review. Vet Microbiol. 2011;149(3–4):298–306.\nTo H, et al. Q fever pneumonia in children in Japan. J Clin Microbiol. 1996;34(3):647–51.\nDupuis G, et al. Incidence of Q fever in Valais. Rev Med Suisse Romande. 1985;105(10):949–54.\nDupuis G, et al. An important outbreak of human Q fever in a Swiss Alpine valley. Int J Epidemiol. 1987;16(2):282–7.\nRichardus JH, et al. Q fever in the Netherlands: a sero-epidemiological survey among human population groups from 1968 to 1983. Epidemiol Infect. 1987;98(2):211–9.\nRichardus JH, et al. Serologisch onderzoek bij dierenartsen in Nederland op bet voorkomen van antistoffen tegen Coxiella burnetii en Brucella abortus. Tijdschr Diergeneeskd. 1984;109(15–16):612–5.\nRichardus JH, et al. Q fever in infancy: a review of 18 cases. Pediatr Infect Dis. 1985;4(4):369–73.\nRichardus JH, et al. Q-koorts in Nederland; een beschrijving van 33 ziektegevallen waargenomen tussen 1979 en 1983. Ned Tijdschr Geneeskd. 1984;128(48):2253–8.\nSchimmer B, et al. Seroprevalence and risk factors for Coxiella burnetii (Q fever) seropositivity in dairy goat farmers’ households in The Netherlands, 2009–2010. PLoS One. 2012;7(7):e42364.\nvan der Hoek W, et al. Proximity to goat farms and Coxiella burnetii seroprevalence among pregnant women. Emerg Infect Dis. 2011;17(12):2360–3.\nKampschreur LM, Hagenaars JC, Wielders CC, Elsman P, Lestrade PJ, Koning OH, Oosterheert JJ, Renders NH, Wever PC. Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak. Epidemiol Infect. 2013;141(4):847–51.\nParker N, Robson J, Bell M. A serosurvey of Coxiella burnetii infection in children and young adults in South West Queensland. Aust N Z J Public Health. 2010;34(1):79–82.\nTozer SJ, et al. Q fever seroprevalence in metropolitan samples is similar to rural\u002Fremote samples in Queensland, Australia. Eur J Clin Microbiol Infect Dis. 2011;30(10):1287–93.\nRuiz-Contreras J, et al. Q fever in children. Am J Dis Child. 1993;147(3):300–2.\nTerheggen U, Leggat PA. Clinical manifestations of Q fever in adults and children. Travel Med Infect Dis. 2007;5(3):159–64.\nWielders CC, et al. Characteristics of hospitalized acute Q fever patients during a large epidemic, The Netherlands. PLoS One. 2014;9(3):e91764.\nSantos AS, et al. Genotypic diversity of clinical Coxiella burnetii isolates from Portugal based on MST and MLVA typing. Int J Med Microbiol. 2012;302(6):253–6.\nTilburg JJ, et al. Epidemic genotype of Coxiella burnetii among goats, sheep, and humans in the Netherlands. Emerg Infect Dis. 2012;18(5):887–9.\nTilburg JJ, et al. Genotypic diversity of Coxiella burnetii in the 2007–2010 Q fever outbreak episodes in The Netherlands. J Clin Microbiol. 2012;50(3):1076–8.\nKampschreur LM, et al. Chronic Q fever in the Netherlands 5 years after the start of the Q fever epidemic: results from the Dutch chronic Q fever database. J Clin Microbiol. 2014;52(5):1637–43.\nKampschreur LM. Chronic Q fever in The Netherlands. PhD thesis, Utrecht University; 2013.",{"VOID":2530},"10.1186\u002Fs13104-015-1389-0","2024-05-16T17:00:58.517+00:00","https:\u002F\u002Fbmcresnotes.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13104-015-1389-0",[2534,2551,2564,2579,2594,2617,2630],{"id":2535,"sortIndex":19,"researcher":18,"roles":2536,"affiliations":2537,"properties":2546,"displayName":2548,"givenName":18,"familyName":18},"77d01c7d-93a6-44e3-ad4f-a0c493003633",[177],[2538],{"id":2539,"sortIndex":19,"affiliation":2540,"properties":18},"6805e702-956d-4456-815f-b1b4582c460e",{"id":2539,"createTime":18,"updateTime":18,"relativeEntities":2541,"slug":18,"properties":2542,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2545,"statistic":18},[],{"title":2543},{"VI":2544},"National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Bilthoven, The Netherlands",[],{"title":2547,"gsAuthor":2549},{"VI":2548},"Edwin N. E. Slok",{"VOID":2550},"[\"GZOCEQwAAAAJ\"]",{"id":2552,"sortIndex":192,"researcher":18,"roles":2553,"affiliations":2554,"properties":2561,"displayName":2563,"givenName":18,"familyName":18},"ffce1284-8485-4d38-9231-c519c5f7ccf0",[177],[2555],{"id":2539,"sortIndex":19,"affiliation":2556,"properties":18},{"id":2539,"createTime":18,"updateTime":18,"relativeEntities":2557,"slug":18,"properties":2558,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2560,"statistic":18},[],{"title":2559},{"VI":2544},[],{"title":2562},{"VI":2563},"Frederika Dijkstra",{"id":2565,"sortIndex":262,"researcher":18,"roles":2566,"affiliations":2567,"properties":2576,"displayName":2578,"givenName":18,"familyName":18},"ccb7f0f3-59c9-4d66-b5c0-9b5f2a374e24",[177],[2568],{"id":2569,"sortIndex":19,"affiliation":2570,"properties":18},"5de52c4a-88d2-4625-9b54-97f232afc749",{"id":2569,"createTime":18,"updateTime":18,"relativeEntities":2571,"slug":18,"properties":2572,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2575,"statistic":18},[],{"title":2573},{"VI":2574},"Department of Paediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands",[],{"title":2577},{"VI":2578},"Esther de Vries",{"id":2580,"sortIndex":261,"researcher":18,"roles":2581,"affiliations":2582,"properties":2591,"displayName":2593,"givenName":18,"familyName":18},"6194b358-33cc-40e1-bfa8-ce9a4da4f8d6",[177],[2583],{"id":2584,"sortIndex":19,"affiliation":2585,"properties":18},"f57f58ef-c9dd-42e6-99ef-824d445d5bd7",{"id":2584,"createTime":18,"updateTime":18,"relativeEntities":2586,"slug":18,"properties":2587,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2590,"statistic":18},[],{"title":2588},{"VI":2589},"Department of Infectious Disease Control, Municipal Health Service Hart voor Brabant, ‘s-Hertogenbosch, the Netherlands",[],{"title":2592},{"VI":2593},"Ariene Rietveld",{"id":2595,"sortIndex":264,"researcher":18,"roles":2596,"affiliations":2597,"properties":2612,"displayName":2614,"givenName":18,"familyName":18},"5900df30-da3a-489a-85d8-2ec2d06f328a",[177],[2598,2604],{"id":2539,"sortIndex":19,"affiliation":2599,"properties":18},{"id":2539,"createTime":18,"updateTime":18,"relativeEntities":2600,"slug":18,"properties":2601,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2603,"statistic":18},[],{"title":2602},{"VI":2544},[],{"id":2605,"sortIndex":192,"affiliation":2606,"properties":18},"1d6a08cf-3661-4fd2-8fff-9bb7bc399bed",{"id":2605,"createTime":18,"updateTime":18,"relativeEntities":2607,"slug":18,"properties":2608,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2611,"statistic":18},[],{"title":2609},{"VI":2610},"Department of Statistics Mathematical Modelling and Data Logistics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands",[],{"title":2613,"gsAuthor":2615},{"VI":2614},"Albert Wong",{"VOID":2616},"[\"Z-JN7vIAAAAJ\"]",{"id":2618,"sortIndex":564,"researcher":18,"roles":2619,"affiliations":2620,"properties":2627,"displayName":2629,"givenName":18,"familyName":18},"2d9060d4-92c6-4291-a05c-5da6e8f2d977",[177],[2621],{"id":2539,"sortIndex":19,"affiliation":2622,"properties":18},{"id":2539,"createTime":18,"updateTime":18,"relativeEntities":2623,"slug":18,"properties":2624,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2626,"statistic":18},[],{"title":2625},{"VI":2544},[],{"title":2628},{"VI":2629},"Daan W. Notermans",{"id":2631,"sortIndex":260,"researcher":18,"roles":2632,"affiliations":2633,"properties":2649,"displayName":2651,"givenName":18,"familyName":18},"709eb14a-c2c1-4d3b-836b-3a5271401b46",[177],[2634,2640],{"id":2539,"sortIndex":19,"affiliation":2635,"properties":18},{"id":2539,"createTime":18,"updateTime":18,"relativeEntities":2636,"slug":18,"properties":2637,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2639,"statistic":18},[],{"title":2638},{"VI":2544},[],{"id":2641,"sortIndex":192,"affiliation":2642,"properties":2648},"1baf1f85-3ecb-4c08-b00b-6d28f2f1569f",{"id":2641,"createTime":18,"updateTime":18,"relativeEntities":2643,"slug":18,"properties":2644,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2647,"statistic":18},[],{"title":2645},{"VI":2646},"Centre for Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands",[],{},{"title":2650},{"VI":2651},"Jim E. van Steenbergen",{"url":2532,"publisher":2653,"properties":2698},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2654,"slug":10,"properties":2655,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":2658,"manageAffiliations":2667,"indexDatabases":2678,"url":18,"thumbnailPath":18,"statistic":2693,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":2656,"eissn":2657},{"EN":13},{"VOID":15},[2659,2663],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":2660,"label":2661,"description":2662,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":2664,"label":2665,"description":2666,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[2668,2673],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":2669,"slug":18,"properties":2670,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2672,"statistic":18},[],{"title":2671},{"EN":39},[41],{"id":43,"createTime":18,"updateTime":18,"relativeEntities":2674,"slug":18,"properties":2675,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2677,"statistic":18},[],{"title":2676},{"EN":47},[],[2679,2686],{"id":68,"indexDatabase":2680,"url":79,"indexYears":80,"academicFieldIds":2685,"indexDatabaseRanking":84},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":2681,"label":2682,"description":2683,"key":76,"publicationTags":2684,"standard":18},[],{"EN":73,"VI":73},{"EN":73,"VI":75},[78],[82,83],{"id":51,"indexDatabase":2687,"url":64,"indexYears":18,"academicFieldIds":2692,"indexDatabaseRanking":18},{"id":53,"createTime":18,"updateTime":18,"relativeEntities":2688,"label":2689,"description":2690,"key":60,"publicationTags":2691,"standard":18},[],{"EN":56,"VI":56},{"EN":58,"VI":59},[62,63],[66],{"impactFactor":19,"impactFactorByYear":2694,"i10Index":96,"i10IndexLast5Year":97,"totalPublication":98,"totalPublicationByYear":2695,"totalCitation":115,"totalCitationByYear":2696,"totalCitationPerPublication":132,"totalCitationPerPublicationByYear":2697,"hindexLast5Year":148,"hindex":148},{"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":93,"2019":87,"2020":94,"2021":89,"2022":95,"2023":91},{"2008":100,"2009":101,"2010":102,"2011":103,"2012":104,"2013":105,"2014":106,"2015":107,"2016":108,"2017":109,"2018":110,"2019":109,"2020":111,"2021":112,"2022":102,"2023":113,"2024":114},{"2008":117,"2009":118,"2010":119,"2011":120,"2012":121,"2013":122,"2014":123,"2015":124,"2016":125,"2017":126,"2018":127,"2019":128,"2020":129,"2021":130,"2022":131},{"2008":134,"2009":135,"2010":136,"2011":137,"2012":138,"2013":139,"2014":140,"2015":141,"2016":142,"2017":143,"2018":144,"2019":145,"2020":146,"2021":147,"2022":89},{"pages":2699,"volume":2700},{"VOID":1527},{"VOID":2174},18,{"total":2701,"publishYear":2176,"statisticByYear":2703},{"2017":262,"2018":192,"2019":262,"2020":261,"2021":261,"2022":192,"2023":262,"2024":262,"2025":192,"2026":192},"2015-09-18",[62,78]]