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A CTV (clinical target volume)-to-PTV margin ranging from 15 mm in LR (left-right) and SI (superior-inferior) and 5–10 mm in AP (anterior-posterior) direction was applied to all patients. The dosimetric influence of this margin was retrospectively calculated by analysing systematic and random components of inter and intra errors of 31 consecutive intermediate- and high-risk localized PCa patients using daily cone beam computed tomography and kV\u002FkV (kilo-Voltage) imaging. For each patient inter variation was assessed by observing the first 4 treatment days, which led to an offline ART-based treatment plan in case of larger variations. Systematic inter uncertainties were larger (1.12 in LR, 2.28 in SI and 1.48 mm in AP) than intra systematic errors (0.44 in LR, 0.69 in SI and 0.80 mm in AP). Same findings for the random error in SI direction with 3.19 (inter) and 2.30 mm (intra), whereas in LR and AP results were alike with 1.89 (inter) and 1.91 mm (intra) and 2.10 (inter) and 2.27 mm (intra), respectively. The calculated margin revealed dimensions of 4–5 mm in LR, 8–9 mm in SI and 6–7 mm in AP direction. Treatment plans which had to be adapted showed smaller variations with 1.12 (LR) and 1.72 mm (SI) for Σ and 4.17 (LR) and 3.75 mm (SI) for σ compared to initial plans with 1.77 and 2.62 mm for Σ and 4.46 and 5.39 mm for σ in LR and SI, respectively. The currently clinically used margin of 15 mm in LR and SI and 5–10 mm in AP direction includes inter and intra uncertainties. The results show that offline ART is feasible which becomes a necessity with further reductions in PTV margins.",{"EN":202,"VI":203},"Adaptive radiotherapy and the dosimetric impact of inter- and intrafractional motion on the planning target volume for prostate cancer patients","Xạ trị thích ứng và tác động liều lượng học của chuyển động giữa các phân liều và trong phân liều lên thể tích bia lập kế hoạch cho bệnh nhân ung thư tuyến tiền liệt",{"VOID":205},"Ghilezan M, Yan D, Martinez A (2010) Adaptive radiation therapy for prostate cancer. Semin Radiat Oncol 20:130–137. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.semradonc.2009.11.007\nMcVicar N, Popescu IA, Heath E (2016) Techniques for adaptive prostate radiotherapy. Phys Medica 32:492–498. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ejmp.2016.03.010\nNijkamp J, Pos FJ, Nuver TT, de Jong R, Remeijer P, Sonke JJ et al (2008) Adaptive radiotherapy for prostate cancer using kilovoltage cone-beam computed tomography: first clinical results. Int J Radiat Oncol Biol Phys 70:75–82. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2007.05.046\nYan D, Lockman D, Brabbins D, Tyburski L, Martinez A (2000) An off-line strategy for constructing a patient-specific planning target volume in adaptive treatment process for prostate cancer. Int J Radiat Oncol Biol Phys 48:289–302. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0360-3016(00)00608-8\nMartinez AA, Yan D, Lockman D, Brabbins D, Kota K, Sharpe M et al (2001) Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer. Int J Radiat Oncol Biol Phys 50:1226–1234. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0360-3016(01)01552-8\nOehler C, Lang S, Dimmerling P, Bolesch C, Kloeck S, Tini A et al (2014) PTV margin definition in hypofractionated IGRT of localized prostate cancer using cone beam CT and orthogonal image pairs with fiducial markers. Radiat Oncol 9:229. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13014-014-0229-z\nSteiner E, Georg D, Goldner G, Stock M (2013) Prostate and patient intrafraction motion: Impact on treatment time-dependent planning margins for patients with endorectal balloon. Int J Radiat Oncol Biol Phys 86:755–761. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2013.02.035\nBastasch MD, Teh BS, Mai W‑Y, McGary JE, Grant WH, Butler EB (2006) Tolerance of endorectal balloon in 396 patients treated with intensity-modulated radiation therapy (IMRT) for prostate cancer. Am J Clin Oncol 29:8–11. https:\u002F\u002Fdoi.org\u002F10.1097\u002F01.coc.0000195099.26957.63\nBergström P, Löfroth PO, Widmark A (1998) High-precision conformal radiotherapy (HPCRT) of prostate cancer—a new technique for exact positioning of the prostate at the time of treatment. Int J Radiat Oncol Biol Phys. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0360-3016(98)00229-6\nBoth S, Wang KKH, Plastaras JP, Deville C, Bar AV, Tochner Z et al (2011) Real-time study of prostate intrafraction motion during external beam radiotherapy with daily endorectal balloon. Int J Radiat Oncol Biol Phys 81:1302–1309. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2010.08.052\nEl-Bassiouni M, Davis JB, El-Attar I, Studer GM, Lütolf UM, Ciernik IF (2006) Target motion variability and on-line positioning accuracy during external-beam radiation therapy of prostate cancer with an endorectal balloon device. Strahlenther Onkol 182:531–536. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-006-1581-1\nElsayed H, Bölling T, Moustakis C, Müller SB, Schüller P, Ernst I et al (2007) Organ movements and dose exposures in teletherapy of prostate cancer using a rectal balloon. Strahlenther Onkol 183:617–624. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-007-1736-8\nGrün A, Kawgan-Kagan M, Kaul D, Badakhshi H, Stromberger C, Budach V et al (2018) Impact of bladder volume on acute genitourinary toxicity in intensity modulated radiotherapy for localized and locally advanced prostate cancer. Strahlenther Onkol. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-018-1398-8\nHille A, Schmidberger H, Töws N, Weiss E, Vorwerk H, Hess CF (2005) The impact of varying volumes in rectal balloons on rectal dose sparing in conformal radiation therapy of prostate cancer: a prospective three-dimensional analysis. Strahlenther Onkol 181:709–716. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-005-1443-2\nJones BL, Gan G, Diot Q, Kavanagh B, Timmerman RD, Miften M (2012) Dosimetric and deformation effects of image-guided interventions during stereotactic body radiation therapy of the prostate using an endorectal balloon. Med Phys 39:3080–3088. https:\u002F\u002Fdoi.org\u002F10.1118\u002F1.4711813\nJones BL, Gan G, Kavanagh B, Miften M (2013) Effect of endorectal balloon positioning errors on target deformation and dosimetric quality during prostate SBRT. Phys Med Biol 58:7995–8006. https:\u002F\u002Fdoi.org\u002F10.1088\u002F0031-9155\u002F58\u002F22\u002F7995\nVanneste BGL, van Wijk Y, Lutgens LC, Van Limbergen EJ, van Lin EN, van de Beek K et al (2018) Dynamics of rectal balloon implant shrinkage in prostate VMAT: influence on anorectal dose and late rectal complication risk. Strahlenther Onkol. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-017-1222-x\nBell K, Heitfeld M, Licht N, Rübe C, Dzierma Y (2017) Influence of daily imaging on plan quality and normal tissue toxicity for prostate cancer radiotherapy. Radiat Oncol 12:7. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13014-016-0757-9\nGuckenberger M, Lawrenz I, Flentje M (2014) Moderately hypofractionated radiotherapy for localized prostate cancer: long-term outcome using IMRT and volumetric IGRT. Strahlenther Onkol 190:48–53. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-013-0443-x\nHüttenrauch P, Witt M, Wolff D, Bosold S, Engenhart-Cabillic R, Sparenberg J et al (2014) Target volume coverage and dose to organs at risk in prostate cancer patients: dose calculation on daily cone-beam CT data sets. Strahlenther Onkol 190:310–316. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-013-0483-2\nRudat V, Nour A, Hammoud M, Alaradi A, Mohammed A (2015) Bildgesteuerte intensitätsmodulierte Strahlentherapie des Prostatakarzinoms: Analyse interfraktioneller Abweichungen und Akutreaktionen. Strahlenther Onkol. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-015-0919-y\nThörnqvist S, Hysing LB, Tuomikoski L, Vestergaard A, Tanderup K, Muren LP et al (2016) Adaptive radiotherapy strategies for pelvic tumors—a systematic review of clinical implementations. Acta Oncol. https:\u002F\u002Fdoi.org\u002F10.3109\u002F0284186X.2016.1156738\nBöckelmann F, Hammon M, Lettmaier S, Fietkau R, Bert C, Putz F (2019) Penile bulb sparing in prostate cancer radiotherapy: dose analysis of an in-house MRI system to improve contouring. Strahlenther Onkol. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-018-1377-0\nRoach M, Hanks G, Thames H, Schellhammer P, Shipley WU, Sokol GH et al (2006) Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys 65:965–974. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2006.04.029\nLettmaier S, Lotter M, Kreppner S, Strnad A, Fietkau R, Strnad V (2012) Long term results of a prospective dose escalation phase-II trial: Interstitial pulsed-dose-rate brachytherapy as boost for intermediate- and high-risk prostate cancer. Radiother Oncol 104:181–186. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.radonc.2012.07.003\nMichalski JM, Lawton C, El Naqa I, Ritter M, O’Meara E, Seider MJ et al (2010) Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 76:361–368. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2009.02.006\nKamino Y, Takayama K, Kokubo M, Narita Y, Hirai E, Kawawda N et al (2006) Development of a four-dimensional image-guided radiotherapy system with a gimbaled X‑ray head. Int J Radiat Oncol Biol Phys 66:271–278. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2006.04.044\nYohannes I, Prasetio H, Kallis K, Bert C (2016) Dosimetric accuracy of the cone-beam CT-based treatment planning of the Vero system: a phantom study. J Appl Clin Med Phys. https:\u002F\u002Fdoi.org\u002F10.1120\u002Fjacmp.v17i4.6194\nVan Herk M, Remeijer P, Rasch C, Lebesque JV (2000) The probability of correct target dosage: dose-population histograms for deriving treatment margins in radiotherapy. Int J Radiat Oncol Biol Phys 47:1121–1135. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0360-3016(00)00518-6\nLumley T (2002) Assessment criteria in a large-scale writing test: What do they really mean to the raters? Lang Test. https:\u002F\u002Fdoi.org\u002F10.1191\u002F0265532202lt230oa\nWilcoxon F (1945) Individual comparisons by ranking method. Biometrics Bull 1:80–83. https:\u002F\u002Fdoi.org\u002F10.2307\u002F3001946\nMcPartlin AJ, Li XA, Kershaw LE, Heide U, Kerkmeijer L, Lawton C et al (2016) MRI-guided prostate adaptive radiotherapy  - a systematic review. Radiother Oncol 119:371–380. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.radonc.2016.04.014\nZelefsky MJ, Kollmeier M, Cox B, Fidaleo A, Sperling D, Pei X et al (2012) Improved clinical outcomes with high-dose image guided radiotherapy compared with non-IGRT for the treatment of clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 84:125–129. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2011.11.047\nWang CW, Chong FC, Lai MK, Pu YS, Wu JK, Cheng JCH (2007) Set-up errors due to endorectal balloon positioning in intensity modulated radiation therapy for prostate cancer. Radiother Oncol 84:177–184. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.radonc.2007.06.009\nSmeenk RJ, Louwe RJW, Langen KM, Shah AP, Kupelian PA, Van Lin ENJT et al (2012) An endorectal balloon reduces intrafraction prostate motion during radiotherapy. Int J Radiat Oncol Biol Phys 83:661–669. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2011.07.028\nStroom JC, De Boer HCJ, Huizenga H, Visser AG (1999) Inclusion of geometrical uncertainties in radiotherapy treatment planning by means of coverage probability. Int J Radiat Oncol Biol Phys 43:905–919. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0360-3016(98)00468-4\nRonson BB, Yonemoto LT, Rossi CJ, Slater JM, Slater JD (2006) Patient tolerance of rectal balloons in conformal radiation treatment of prostate cancer. Int J Radiat Oncol Biol Phys 64:1367–1370. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2005.11.001\nBirkner M, Yan D, Alber M, Liang J, Nüsslin F (2003) Adapting inverse planning to patient and organ geometrical variation: algorithm and implementation. Med Phys 30:2822–2831. https:\u002F\u002Fdoi.org\u002F10.1118\u002F1.1610751\nYan D, Vicini F, Wong J, Martinez A (1997) Adaptive radiation therapy. Phys Med Biol 42:123. https:\u002F\u002Fdoi.org\u002F10.1088\u002F0031-9155\u002F42\u002F1\u002F008\nYan D, Wong J, Vicini F, Michalski J, Pan C, Frazier A et al (1997) Adaptive modification of treatment planning to minimize the deleterious effects of treatment setup errors. Int J Radiat Oncol Biol Phys 38:197–206. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0360-3016(97)00229-0\nWang KKH, Vapiwala N, Bui V, Deville C, Plastaras JP, Bar-Ad V et al (2014) The impact of stool and gas volume on intrafraction prostate motion in patients undergoing radiotherapy with daily endorectal balloon. Radiother Oncol 112:89–94. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.radonc.2014.05.008\nSchröder FH, Hermanek P, Denis L, Fair WR, Gospodarowicz MK, Pavone-Macaluso M (1992) The TNM classification of prostate cancer. Prostate Suppl 4:129–138\nGleason DF (1990) Histologic grading of prostate cancer. In: Bostwick MD (ed) Pathology of the prostate. Churchill Livingstone, New York, pp 83–93\nD’Amico a V, Whittington R, Malkowicz SB, Schultz D, Blank K, Broderick GA et al (1998) Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280:969–974",{"VOID":207},"10.1007\u002Fs00066-020-01596-x","PUBLICATION","VERIFIED","2025-01-28T10:41:24.188+00:00","Auto Verify",[213],"VI","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00066-020-01596-x",[216,232,246,259,275,288],{"id":217,"sortIndex":21,"researcher":20,"roles":218,"affiliations":220,"properties":229,"displayName":231,"givenName":20,"familyName":20},"c053df34-f097-4d66-a036-86e803fb9beb",[219],"AUTHOR",[221],{"id":222,"sortIndex":21,"affiliation":223,"properties":20},"b25adde9-20ab-45d3-a80c-f9b89b8efb0c",{"id":222,"createTime":20,"updateTime":20,"relativeEntities":224,"slug":20,"properties":225,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":228,"statistic":20},[],{"title":226},{"VI":227},"Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, 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Reactor neutron therapy of locally recurrent breast cancer. In: Kogelnik HD, editor. Progress in Radio-Oncology, Vol. V, Monduzzi Editore, Bologna 1995;691–694.",{},{"id":20,"text":719,"url":20,"identifiers":720},"Auberger T, Reuschel W, Kneschaurek P, et al. The role of fast neutrons in treatment of squamous cell carcinomas of the head and neck: The European experience. Radiologie 1995;35(Suppl. 1):150.",{},{"id":20,"text":722,"url":20,"identifiers":723},"Bley CR, Ohlerth S, Roos M, et al. Influence of pretreatment polarographically measured oxygenation levels in spontaneous canine tumors treated with radiation therapy. Strahlenther Onkol 2006;182:518–524.",{"doi":724},"10.1007\u002Fs00066-006-1519-7",{"id":20,"text":726,"url":20,"identifiers":727},"Breitkreutz H, Wagner FM, Röhrmoser A, et al. Spectral fluence rates of the fast reactor neutron beam MedApp at FRM II. Nucl Inst and Meth 2008;593A:466–471.",{"doi":728},"10.1016\u002Fj.nima.2008.05.008",{"id":20,"text":730,"url":20,"identifiers":731},"Bremer M, Neuhofer C, Zimmermann F, et al. Palliative radiotherapy of malignant melanoma with reactor fission neutron therapy (RENT): a prospective study. Rad Oncol Investig 1999;7:118–124.",{"doi":732},"10.1002\u002F(SICI)1520-6823(1999)7:2\u003C118::AID-ROI8>3.0.CO;2-6",{"id":20,"text":734,"url":20,"identifiers":735},"Grosu AL, Molls M, Zimmermann FB, et al. High-precision radiation therapy with integrated biological imaging and tumor monitoring — Evolution of the Munich concept and future research options. Strahlenther Onkol 2006;182:361–368.",{"doi":736},"10.1007\u002Fs00066-006-1504-1",{"id":20,"text":738,"url":20,"identifiers":739},"Huber R, Schraube H, Nahrstedt U, et al. Dose-response relationships of micronuclei in human lymphocytes induced by fission neutrons and by low LET radiations. Mutat Res 1994;306:135–141.",{"doi":740},"10.1016\u002F0027-5107(94)90024-8",{"id":20,"text":742,"url":20,"identifiers":743},"Kampfer S, Wagner FM, Loeper B, et al. MEDAPP: Die neue Neutronentherapieanlage am FRM II in Garching. Strahlenther Onkol 2007;183 (Sondemr.1):72.",{},{"id":20,"text":745,"url":20,"identifiers":746},"Karger CP, Jaekel O. Current status and new developments in ion therapy. Strahlenther Onkol 2007;183:295–300.",{"doi":747},"10.1007\u002Fs00066-007-1645-x",{"id":20,"text":749,"url":20,"identifiers":750},"Koester L. Applicability of reactor fission neutrons for radiation therapy of cancer. Nucl Sci Appl 1984;2:79–96.",{},{"id":20,"text":752,"url":20,"identifiers":753},"Kummermehr J, Schraube H, Ries G, et al. Biological effectiveness of neutrons and π-mesons in gut, bone, and transplantable tumors. Strahlenther Onkol 1989;165:276–282.",{},{"id":20,"text":755,"url":20,"identifiers":756},"Murray EM, Werner ID, Schmitt G, et al. Neutron versus photon radiotherapy for local control in inoperable breast cancer. Strahlenther Onkol 2005;181:77–81.",{"doi":757},"10.1007\u002Fs00066-005-1298-6",{"id":20,"text":759,"url":20,"identifiers":760},"Ries G, Breit A, Kummermehr J, et al. The RENT Project: Radiobiological Results and Planned Clinical Application. Strahlenther Onkol 1985;161:791–793.",{},{"id":20,"text":762,"url":20,"identifiers":763},"Sakata KI, Someya M, Nagakura H, et al. Clinical study of hypoxia using endogenous hypoxic markers and polarographic oxygen electrodes. Strahlenther Onkol 2006;182:511–517.",{"doi":764},"10.1007\u002Fs00066-006-1532-x",{"id":20,"text":766,"url":20,"identifiers":767},"Schmid E, Schraube H, Bauchinger M. Chromosome aberration frequencies in human lymphocytes irradiated in a phantom by a mixed beam of fission neutrons and γ-rays. Int J Radiat Biol 1998;73:263–267.",{"doi":768},"10.1080\u002F095530098142356",{"id":20,"text":770,"url":20,"identifiers":771},"Schraube H, Alberts WG, Brede H, et al. Die Bestimmung der Energiedosis eines Neutronenstrahls mit Hilfe von Ionisationskammern — Ein Kompendium (GSF-Bericht 10\u002F03). GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg 2003;40pp.",{},{"id":20,"text":773,"url":20,"identifiers":774},"Schulz-Ertner D, Nikoghosyan A, Hof H, et al. Carbon ion treatment in low-grade-chondrosarcoma of the skull base. Strahlenther Onkol 2006;182:Suppl.1:29.",{},{"id":20,"text":776,"url":20,"identifiers":777},"Tacev, T, Vacek, A, Ptackova, B, et al. Hypoxic versus normoxic external-beam irradiation of cervical carcinoma combined with californium-252 neutron brachytherapy — comparative treatment results of a 5-year randomized study. Strahlenther Onkol 2005;181:273–284.",{"doi":778},"10.1007\u002Fs00066-005-1303-0",{"id":20,"text":780,"url":20,"identifiers":781},"Tanaka K, Gajendiran N, Mohankumar M. RBE values and dose rate effects on the ratio of translocation to dicentrics yields in neutrons with low-energy spectrum. International Congress Series 2002;1236:383–385.",{"doi":782},"10.1016\u002FS0531-5131(01)00870-6",{"id":20,"text":784,"url":20,"identifiers":785},"Thamm R, Loeper B, Wagner FM, et al. Entwicklung einer digitalen Patientenakte ‘RISSKA’ für die Strahlentherapie mit Neutronen am Forschungsreaktor München (FRM II). Strahlenther Onkol 2006;182 (Sondernr.1):115.",{},{"id":20,"text":787,"url":20,"identifiers":788},"Wagner FM, Koester L, Auberger Th, et al. Fast reactor neutrons for the treatment of superficial carcinomas. Nucl Sci Eng 1992;110:32–37.",{"doi":789},"10.13182\u002FNSE92-A23873",{"id":20,"text":791,"url":20,"identifiers":792},"Wittig A, Moss RL, Stecher-Rasmussen F, et al. Neutron activation of patients following boron neutron capture therapy of brain tumors at the High Flux Reactor (HFR) Petten (EORTC trials 11961 and 11011). Strahlenther Onkol 2005;181:774–782.",{"doi":793},"10.1007\u002Fs00066-005-1433-4",{"id":795,"createTime":796,"updateTime":797,"relativeEntities":798,"slug":799,"properties":800,"entityType":208,"verifyStatus":209,"verifyTime":811,"verifyNote":211,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":812,"fullTextUrl":20,"authors":813,"publicationType":302,"publisherRelationship":978,"citationCount":21,"citationInfo":1030,"publishDate":1033,"publishYear":1031,"citationAnalyzeStatus":1034,"lastCitationAnalyze":1035,"indexDatabases":1036,"openAccess":20,"references":20,"isForceReanalyzing":358},"f376caff-c357-4ce8-8140-c4579f5f4056","2024-02-06T06:12:32.113+00:00","2026-07-27T01:24:25.150+00:00",[],"Focal-cavity-radiotherapy-after-neurosurgical-resection-of-brain-metastases-sparing-neurotoxicity-without-compromising-locoregional-control",{"abstract":801,"title":803,"gsPaper":805,"references":807,"doi":809},{"EN":802},"Does focal cavity radiotherapy after resection of brain metastasis “spare” whole-brain radiotherapy, which is associated with toxicity for patients, through the complete course of their disease without compromising long-term local control of the brain? We retrospectively analyzed outcomes of patients who underwent adjuvant focal cavity radiotherapy between 2014 and 2021 at our center. A total of 83 patients with 86 resected brain metastases were analyzed. 64% had singular, 36% two to four brain metastases. In cases with multiple metastases, omitted lesions were treated with radiosurgery. Median follow-up was 7.3 months (range 0–71.2 months), 1‑year overall survival rate was 57.8% (95% CI 44.9–68.8%). Radiotherapy was administered with a median biologically effective dose (α\u002Fβ 10) surrounding the planning target volume of 48 Gy (range 23.4–60 Gy). Estimated 1‑year local control rate was 82.7% (95% CI 67.7–91.2%), estimated 1‑year distant brain control rate was 55.7% (95% CI 40.5–68.4%), estimated 1‑year leptomeningeal disease rate was 16.0% (95% CI 7.3–32.9%). Eleven distant brain recurrences could be salvaged with radiosurgery. In the further course of disease, 14 patients (17%) developed disseminated metastatic disease in the brain. Estimated 1‑year free of whole-brain radiotherapy rate was 72.3% (95% CI 57.1–82.9%). All applied treatments led to an estimated 1‑year neuro-control rate of 79.1% (95% CI 65.0–88.0%), estimated 1‑year radionecrosis rate was 23% (95% CI 12.4–40.5%). In our single-center study, focal cavity radiotherapy was associated with high local control. In three out of four patients, whole-brain radiotherapy could be avoided in the complete course of disease, using radiosurgery as salvage approach without compromising neuro-control.",{"EN":804},"Focal cavity radiotherapy after neurosurgical resection of brain metastases: sparing neurotoxicity without compromising locoregional control",{"VOID":806},"[\"5003775909143125839\"]",{"VOID":808},"Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D (2022) Treatment for brain metastases: aSCO-SNO-ASTRO guideline. J Clin Oncol 40:492–516. https:\u002F\u002Fdoi.org\u002F10.1200\u002FJCO.21.02314\nMahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G (2017) Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1040–1048. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1470-2045(17)30414-X\nBrown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary J‑P, Hadjipanayis CG, Urbanic JJ, Barker FG, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D (2017) Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C\u002FCEC·3): a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1049–1060. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1470-2045(17)30441-2\nRedmond KJ, De Salles AAF, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan J, Suh J, Yomo S, Sahgal A (2021) Stereotactic Radiosurgery for postoperative metastatic surgical cavities: a critical review and international stereotactic radiosurgery society (ISRS) practice guidelines. Int J Radiat Oncol Biol Phys 111:68–80. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijrobp.2021.04.016\nMinniti G, Niyazi M, Andratschke N, Guckenberger M, Palmer JD, Shih HA, Lo SS, Soltys S, Russo I, Brown PD, Belka C (2021) Current status and recent advances in resection cavity irradiation of brain metastases. Radiat Oncol 16:73. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13014-021-01802-9\nKamp MA, Rapp M, Bühner J, Slotty PJ, Reichelt D, Sadat H, Dibué-Adjei M, Steiger H‑J, Turowski B, Sabel M (2015) Early postoperative magnet resonance tomography after resection of cerebral metastases. Acta Neurochir 157:1573–1580. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00701-015-2479-4\nWen PY, Chang SM, Van den Bent MJ, Vogelbaum MA, Macdonald DR, Lee EQ (2017) Response assessment in neuro-oncology clinical trials. J Clin Oncol 35:2439–2449. https:\u002F\u002Fdoi.org\u002F10.1200\u002FJCO.2017.72.7511\nNichelli L, Casagranda S (2021) Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis. Curr Opin Oncol 33:597–607. https:\u002F\u002Fdoi.org\u002F10.1097\u002FCCO.0000000000000793\nKanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 48:452–458. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fbmt.2012.244\nGutschenritter T, Venur VA, Combs SE, Vellayappan B, Patel AP, Foote M, Redmond KJ, Wang TJC, Sahgal A, Chao ST, Suh JH, Chang EL, Ellenbogen RG, Lo SS (2020) The judicious use of stereotactic radiosurgery and hypofractionated stereotactic radiotherapy in the management of large brain metastases. Cancers 13:70. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fcancers13010070\nKahl K‑H, Balagiannis N, Höck M, Schill S, Roushan Z, Shiban E, Müller H, Grossert U, Konietzko I, Sommer B, Maurer CJ, Berlis A, Heidecke V, Janzen T, Stüben G (2021) Intraoperative radiotherapy with low-energy x‑rays after neurosurgical resection of brain metastases—an Augsburg University Medical Center experience. Strahlenther Onkol. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-021-01831-z\nEitz KA, Lo SS, Soliman H, Sahgal A, Theriault A, Pinkham MB, Foote MC, Song AJ, Shi W, Redmond KJ, Gui C, Kumar AMS, Machtay M, Meyer B, Combs SE (2020) Multi-institutional analysis of prognostic factors and outcomes after hypofractionated stereotactic radiotherapy to the resection cavity in patients with brain metastases. JAMA Oncol. https:\u002F\u002Fdoi.org\u002F10.1001\u002Fjamaoncol.2020.4630\nDincoglan F, Sager O, Uysal B, Demiral S, Gamsiz H, Gündem E, Elcim Y, Dirican B, Beyzadeoglu M (2019) Evaluatıon of hypofractıonated stereotactıc radıotherapy (HFSRT) to the resectıon cavıty after surgıcal resectıon of braın metastases: a single center experıence. Indian J Cancer 56:202. https:\u002F\u002Fdoi.org\u002F10.4103\u002Fijc.IJC_345_18\nSpecht HM, Kessel KA, Oechsner M, Meyer B, Zimmer C, Combs SE (2016) HFSRT of the resection cavity in patients with brain metastases. Strahlenther Onkol 192:368–376. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00066-016-0955-2\nCombs SE, Bilger A, Diehl C, Bretzinger E, Lorenz H, Oehlke O, Specht HM, Kirstein A, Grosu A‑L (2018) Multicenter analysis of stereotactic radiotherapy of the resection cavity in patients with brain metastases. Cancer Med 7:2319–2327. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fcam4.1477\nMinniti G, Lanzetta G, Capone L, Giraffa M, Russo I, Cicone F, Bozzao A, Alongi F, Nicosia L, Fineschi G, Marchetti L, Tufo T, Bianciardi F, Esposito V, Gentile P, Paolini S (2021) Leptomeningeal disease and brain control after postoperative stereotactic radiosurgery with or without immunotherapy for resected brain metastases. J Immunother Cancer 9:e3730. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fjitc-2021-003730\nNguyen TK, Sahgal A, Detsky J, Atenafu EG, Myrehaug S, Tseng C‑L, Husain Z, Heyn C, Maralani P, Ruschin M, Perry J, Soliman H (2020) Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases. Neuro-Oncology 22:84–93. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fneuonc\u002Fnoz144\nLe Rhun E, Dhermain F, Vogin G, Reyns N, Metellus P (2016) Radionecrosis after stereotactic radiotherapy for brain metastases. Expert Rev Neurother 16:903–914. https:\u002F\u002Fdoi.org\u002F10.1080\u002F14737175.2016.1184572\nKaufmann TJ, Smits M, Boxerman J, Huang R, Barboriak DP, Weller M, Chung C, Tsien C, Brown PD, Shankar L, Galanis E, Gerstner E, van den Bent MJ, Burns TC, Parney IF, Dunn G, Brastianos PK, Lin NU, Wen PY, Ellingson BM (2020) Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases. 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goal of this work was to assess optimal treatment positioning of 3D conformal radiotherapy (3DCRT) for high-risk prostate cancer patients. Treatment plans of 25 patients in different patient positions were evaluated: with knee and ankle support (KAS) in the supine position and with a belly board (BB) in the prone position both with full (FB) and empty bladder (EB). Planning target volumes (PTVs) for pelvis, prostate and vesicles, prostate, and organs at risk (OARs) were delineated. Dose and overlapping volumes were evaluated. Overlapping volumes were significantly smaller with a FB than with an EB. No significant differences were found in overlapping volumes with respect to patient fixation systems, but the percentage values of dose to the OARs showed significantly better results employing KAS than a BB. A FB reduced the dose volumes to the OARs. Comparison with respect to circumference of abdomen (CA) showed significantly smaller overlapping at large CA in most of the cases. Supine position is suggested with KAS combined with a FB (especially in cases of larger CA) when using 3DCRT with planning technique modification for high-risk prostate cancer patients to reduce the dose of OARs, based on our results.",{"EN":1047},"Patient positioning variations to reduce dose to normal tissues during 3D conformal radiotherapy for high-risk prostate cancer",{"VOID":1049},"[\"15083837734228712677\"]",{"VOID":1051},"Bayley AJ, Catton CN, Haycocks T et al (2004) A randomized trial of supine vs. prone positioning in patients undergoing escalated dose conformal radiotherapy for prostate cancer. Radiother Oncol 70:37–44\nBittner N, Butler WM, Reed JL et al (2010) Electromagnetic tracking of intrafraction prostate displacement in patients externally immobilized in the prone position. Int J Radiat Oncol Biol Phys 77:490–495\nCzigner K, Ágoston P, Forgács GY et al (2009) Assessment of overlapping of organs at risk and planning target volumes at high risk prostate cancer irradiation. Radiother Oncol 92(Suppl 1):69\nDawson LA, Litzenberg DW, Brock KK et al (2000) A comparison of ventilatory prostate movement in four treatment positions. Int J Radiat Oncol Biol Phys 48:319–323\nDe Meerleer GO, Villeirs GM, Vakaet L et al (2004) The incidence of inclusion of the sigmoid colon and small bowel in the planning target volume in radiotherapy for prostate cancer. Strahlenther Onkol 180:573–581\nDolezel M, Odrazka K, Vaculikova M et al (2010) Dose escalation in prostate radiotherapy up to 82 Gy using simultaneous integrated boost: direct comparison of acute and late toxicity with 3D-CRT 74 Gy and IMRT 78 Gy. Strahlenther Onkol 186:197–202\nGallagher MJ, Brereton HD, Rostock RA et al (1986) A prospective study of treatment techniques to minimise the volume of pelvic small bowel with reduction of acute and late effects associated with pelvic irradiation. Int J Radiat Oncol Biol Phys 12:1565–1573\nHanks GE, Hanlon AL, Epstein B et al (2002) Dose response in prostate cancer with 8–12 years follow-up. Int J Radiat Oncol Biol Phys 54:427–435\nHentschel B, Oehler W, Strauss D et al (2011) Definition of the CTV prostate in CT and MRI by using CT-MRI image fusion in IMRT planning for prostate cancer. Strahlenther Onkol 187:183–190\nHille A, Töws N, Schmidberger H, Hess CF (2005) A prospective three-dimensional analysis about the impact of differences in the clinical target volume in prostate cancer irradiation on normal-tissue exposure. A potential for increasing the benefit\u002Frisk ratio. Strahlenther Onkol 181:789–795\nHuang EH, Pollack A, Levy L et al (2002) Late rectal toxicity: dose–volume effects of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 54:1314–1321\nKato T, Obata Y, Kadoya N et al (2009) A comparison of prone three-dimensional conformal radiotherapy with supine intensity-modulated radiotherapy for prostate cancer: which technique is more effective for rectal sparing? Br J Radiol 82:654–661\nKitamura K, Shirato H, Seppenwoolde Y et al (2002) Three-dimensional intrafractional movement of prostate measured during real-time tumortracking radiotherapy in supine and prone treatment positions. Int J Radiat Oncol Biol Phys 53:1117–1123\nKuban DA, Tucker SL, Dong L et al (2008) Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys 70:67–74\nLiu B, Lerma FA, Patel S et al (2008) Dosimetric effects of the prone and supine positions on image guided localized prostate cancer radiotherapy. Radiother Oncol 88:67–76\nMcLaughlin PW, Evans C, Feng M et al (2010) Radiographic and anatomic basis for prostate contouring errors and methods to improve prostate contouring accuracy. Int J Radiat Oncol Biol Phys 76:369–378\nMcLaughlin PW, Wygoda A, Sahijdak W et al (1999) The effect of patient position and treatment technique in conformal treatment of prostate cancer. Int J Radiat Oncol Biol Phys 45:407–413\nMichalski JM, Bae K, Roach M et al (2010) Long-term toxicity following 3D conformal radiation therapy for prostate cancer from the RTOG 9406 phase I\u002FII dose escalation study. Int J Radiat Oncol Biol Phys 76:14–22\nMichalski JM, Purdy JA, Winter K et al (2000) Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG\u002FRTOG 9406. Int J Radiat Oncol Biol Phys 46:391–402\nNakamura N, Shikama N, Takahashi O et al (2010) Variability in bladder volumes of full bladders in definitive radiotherapy for cases of localized prostate cancer. Strahlenther Onkol 186:637–642\nOnal C, Topkan E, Efe E et al (2009) Comparison of rectal volume definition techniques and their influence on rectal toxicity in patients with prostate cancer treated with 3D conformal radiotherapy: a dose-volume analysis. Radiat Oncol 11(4):14\nO’Neill L, Armstrong J, Buckney S et al (2008) A phase II trial for the optimisation of treatment position in the radiation therapy of prostate cancer. Radiother Oncol 88:61–66\nPinkawa M, Piroth MD, Holy R et al (2011) Combination of dose escalation with technological advances (intensity-modulated and image-guided radiotherapy) is not associated with increased morbidity for patients with prostate cancer. Strahlenther Onkol 187:479–484\nShah AP, Kupelian PA, Willoughby TR et al (2011) An evaluation of intrafraction motion of the prostate in the prone and supine positions using electromagnetic tracking. Radiother Oncol 99:37–43\nStorey MR, Pollack A, Zagars G (2000) Complications from radiotherapy dose escalation in prostate cancer: preliminary results of a randomized trial. Int J Radiat Oncol Biol Phys 48:635–642\nSzumacher E, Harnett N, Warner S et al (2010) Effectiveness of educational intervention on the congruence of prostate and rectal contouring as compared with a gold standard in three-dimensional radiotherapy for prostate. Int J Radiat Oncol Biol Phys 76:379–385\nViani GA, Stefano EJ, Afonso SL (2009) Higher-than-conventional radiation doses in localized prostate cancer treatment: a meta-analysis of randomized, controlled trials. Int J Radiat Oncol Biol Phys 74:1405–1418\nWilder RB, Chittenden L, Mesa AV et al (2009) A prospective study of intrafraction prostate motion in the prone vs. supine position. Int J Radiat Oncol Biol Phys 77:165–170\nZelefsky MJ, Happersett L, Leibel SA et al (1997) The effect of treatment positioning on normal tissue dose in patients with prostate cancer treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 37:13–19\nZelefsky MJ, Leibel SA, Gaudin PB et al (1998) Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer. Int J Radiat Oncol Biol Phys 41:491–500\nZelefsky MJ, Levin EJ, Hunt M et al (2008) Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. 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Pathological fractures, instability-related patient immobility and the extent of bone metastasis have been reported to affect patient outcome and these parameters have therefore been used for treatment stratification. We report on stability-dependent fracture and survival rates in over 300 non-small cell lung cancer (NSCLC) patients. Data from 303 patients with 868 osteolytic metastases treated with radiotherapy (RT) between 2000 and 2012 were evaluated retrospectively. In NSCLC patients with bone metastases only, the retrospective 6- and 12-month overall survival (OS) rates were 76.7 and 47.2 %, respectively. In patients with additional non-bone distant metastases, these values were 60.0 and 34.0 %, respectively. Survival rates were significantly lower in patients with multiple bone metastases and in those suffering pathological fractures (p = 0.017). No significant impact of histological type, location of spinal lesions or treatment regime was detected. Furthermore, stability assessment revealed no influence of vertebral column stability on patient outcome (p = 0.739). Our analysis demonstrated a correlation between the pathological fractures of bone lesions, the number of bone metastases, additional distant metastases and survival. The results offer a rationale for future prospective investigations.",{"EN":1317},"Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases",{"VOID":1319},"[\"9860372978658427496\",\"12704075094476638361\"]",{"VOID":1321},"Coleman RE (2000) Management of bone metastases. Oncologist 5:463–470\nDecroisette C, Monnet I, Berard H et al (2011) Epidemiology and treatment costs of bone metastases from lung cancer. A French prospective, observation, multicenter study (GFPC 0601). J Thorac Oncol 6:576–582\nJanjan N, Lutz ST, Bedwinek JM et al (2009) Therapeutic guidelines for the treatment of bone metastasis: a report from the American College of Radiology Appropriateness Criteria Expert Panel on Radiation Oncology. J Palliat Med 12:417–426\nKarnofsky DA, Burchenal JH (1949) The clinical evaluation of chemotherapeutic agents in cancer. In: MacLeod CM (Hrsg) Evaluation of chemotherapeutic agents. Columbia Univ Press, New York, S 191–205\nKatagiri H, Takahashi M, Wakai K et al (2005) Prognostic factors and a scoring system for patients with skleletal metastasis. J Bone Joint Surg Br 87:698–703\nKlimo P Jr, Kestle JR, Schmidt MH (2004) Clinical trials and evidence-based medicine for metastatic spine disease. Neurosurg Clin N Am 15:549–564\nNiewald M, Tkocz HJ, Abel U et al (1996) Rapid course radiation therapy vs. more standard treatment: a randomized trial for bone metastases. Int J Radiat Oncol Biol Phys 36:1085–1089\nRades D, Douglas S, Veninga T et al (2012) Metastatic spinal cord compression in non-small cell lung cancer patients. Prognostic factors in a series of 356 patients. Strahlenther Onkol 188(6):472–476\nRades D, Panzner A, Rudat V et al (2011) Dose escalation of radiotherapy for metastatic spinal cord compression (MSCC) in patients with relatively favorable survival prognosis. Strahlenther Onkol 187(11):729–735\nRief H, Jensen AD, Bruckner T et al (2011) Isometric muscle training of the spine musculature in patients with spinal bony metastases under radiation therapy. BMC Cancer 11:482\nRoodman GD (2004) Mechanisms of bone metastasis. Discov Med 4(22):144–148\nSandler A, Gray R, Perry MC et al (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542–2550\nSatoh H, Ishikawa H, Ohara G et al (2007) Long-term survivors after chemotherapy in advanced non-small cell cancer. Anticancer Res 27:4457–4460\nSatoh H, Ishikawa H, Yamashita YT et al (1998) Analysis of long-term survivors after platinum containing chemotherapy in advanced non-small cell lung cancer. Anticancer Res 18:1295–1298\nScagliotti GV, Parikh P, Pawl J von et al (2008) Phase III study comparing cisplatin plus gemcitabline with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26:3543–3551\nSugiura H, Yamada K, Sugiura T et al (2008) Predictors of survival in patients with bone metastasis of lung cancer. Clin Orthop Relat Res 466:729–736\nTemel JS et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742\nTong G, Gillick L, Hendrickson FR (1982) The palliation of symptomatic osseous metastases: final result of the Study by the Radiation Therapy Oncology Group. Cancer 50:893–899\nTsuya A, Kurata T, Tamura K et al (2007) Skeletal metastases in non-small cell lung cancer: a retrospective study. Lung Cancer 57:229–232\nLinden YM van der, Dijkstra SP, Vonk EJ et al (2005) Dutch bone metastases group. Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. 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From 01\u002F2007 to 08\u002F2007, 46 patients with previously untreated brain metastases were recruited at eight centers. QoL was measured at start of treatment (T0) and at 3 months (T3mo). In the pilot study, two combinations of QoL instruments could be used at the discretion of the centers (A: EORTC QLQ-C30 and B: EORTC QLQ-C15-PAL both with brain module BN20, assessment by proxies with A: Palliative Care Outcome Scale, B: self-constructed brain-specific instrument). All patients received whole-brain radiotherapy, four with an additional boost irradiation. At T3mo, 26\u002F46 patients (56.5%) had died. 17\u002F20 survivors (85%) completed the questionnaires. In 3-month survivors, QoL deteriorated in most domains, significant in drowsiness, hair loss and weakness of legs. The scores for headaches and seizures were slightly better after 3 months. Assessment by proxies also suggested worsening of QoL. Initial QoL at T0 was better in those alive than in those deceased at T3mo, significant for physical function and for the symptom scales of fatigue and pain, motor dysfunction, communication deficit and weakness of legs. Practicability and compliance appeared better with the (shorter) version B. This version is now used in the ongoing main phase of the study with additional centers. First results indicate a moderate worsening of QoL during the first 3 months after start of palliative radiotherapy for brain metastases. QoL at initiation of radiotherapy may be prognostic for survival.",{"EN":1520},"Effects of Radiotherapy for Brain Metastases on Quality of Life (QoL)",{"VOID":1522},"[\"8586331184655368240\"]",{"VOID":1524},"Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993;85:365–76.\nBausewein C, Fegg M, Radbruch L, et al. Validation and clinical application of the German version of the Palliative Care Outcome Scale. J Pain Symptom Manage 2005;30:51–62.\nBezjak A, Adam J, Barton R, et al. Symptom response after palliative radiotherapy for patients with brain metastases. Eur J Cancer 2002;38:487–96.\nBrown PD, Asher AL, Farace E. Adjuvant whole brain radiotherapy: strong emotions decide but rational studies are needed. Int J Radiat Oncol Biol Phys 2008;70:1305–9.\nCorn BW, Moughan J, Knisely JP, et al. Prospective evaluation of quality of life and neurocognitive effects in patients with multiple brain metastases receiving whole-brain radiotherapy with or without thalidomide on Radiation Therapy Oncology Group (RTOG) trial 0118. Int J Radiat Oncol Biol Phys 2008;71:71–8.\nDiBiase SJ, Chin LS, Ma L. Influence of gamma knife radiosurgery on the quality of life in patients with brain metastases. Am J Clin Oncol 2002;25:131–4.\nDoyle M, Bradley NM, Li K, et al. Quality of life in patients with brain metastases treated with a palliative course of whole-brain radiotherapy. J Palliat Med 2007;10:367–74.\nFahrig A, Ganslandt O, Lambrecht U, et al. Hypofractionated stereotactic radiotherapy for brain metastases. Results from three different dose concepts. Strahlenther Onkol 2007;183:625–30.\nFayers PM. Interpreting quality of life data: population-based reference data for the EORTC QLQ-C30. Eur J Cancer 2001;37:1331–4.\nGaspar L, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 1997;37:745–51.\nGroenvold M, Petersen MA, Aaronson NK, et al., EORTC Quality of Life Group. The development of the EORTC QLQ-C15-PAL: a shortened questionnaire for cancer patients in palliative care. Eur J Cancer 2006;42:55–64.\nKlein M, Postma TJ, Taphoorn MJ, et al. The prognostic value of cognitive functioning in the survival of patients with high-grade glioma. Neurology 2003;61:1796–8.\nKramer JA, Curran D, Piccart M, et al. Identification and interpretation of clinical and quality of life prognostic factors for survival and response to treatment in first-line chemotherapy in advanced breast cancer. Eur J Cancer 2000;36:1498–506.\nLi J, Bentzen SM, Renschler M, et al. Regression after whole-brain radiation therapy for brain metastases correlates with survival and improved neurocognitive function. J Clin Oncol 2007;25:1260–6.\nMauer ME, Taphoorn MJ, Bottomley A, et al., EORTC Brain Cancer Group. Prognostic value of health-related quality-of-life data in predicting survival in patients with anaplastic oligodendrogliomas, from a phase III EORTC Brain Cancer Group study. J Clin Oncol 2007;25:5731–7.\nMeyers CA, Hess KR, Yung WK, et al. Cognitive function as a predictor of survival in patients with recurrent malignant glioma. J Clin Oncol 2000;18:646–50.\nNieder C, Astner ST, Grosu AL, et al. The role of postoperative radiotherapy after resection of a single brain metastasis. Combined analysis of 643 patients. Strahlenther Onkol 2007;183:576–80.\nRades D, Bohlen G, Dunst J, et al. Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases. Strahlenther Onkol 2008;184:30–5.\nRades D, Bohlen G, Lohynska R, et al. Whole-brain radiotherapy with 20 Gy in 5 fractions for brain metastases in patients with cancer of unknown primary (CUP). Strahlenther Onkol 2007;183:631–6.\nSehlen S, Lenk M, Hollenhorst H, et al. Quality of life (QoL) as predictive mediator variable for survival in patients with intracerebral neoplasma during radiotherapy. Onkologie 2003;26:38–43.\nVelikova G, Booth L, Smith AB, et al. Measuring quality of life in routine oncology practice improves communication and patient well-being: A randomized controlled trial. 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analyze the impact of nutritional counseling on the development of hypothyroidism after (chemo)radiotherapy in head and neck cancer patients to propose a new normal tissue complication probability (NTCP) model. At baseline, at the end of (chemo)radiotherapy, and during follow-up, thyroid-stimulating hormone (TSH) with free thyroxin (fT3 and fT4), nutritional status, and nutrient intake were prospectively analyzed in 46 out of 220 screened patients. Patients received (chemo)radiotherapy within an intervention (individual nutritional counseling every 2 weeks during therapy) and a control group (no nutritional counseling). Overall median follow-up was 16.5 [IQR: 12; 22] months. Fourteen patients (30.4%) presented with hypothyroidism after 13.5 [8.8; 17] months. During (chemo)radiotherapy, nutritional status worsened in the entire cohort: body mass index (p \u003C 0.001) and fat-free mass index (p \u003C 0.001) decreased, calorie deficit (p = 0.02) increased, and the baseline protein intake dropped (p = 0.028). The baseline selenium intake (p = 0.002) increased until the end of therapy. Application of the NTCP models by Rønjom, Cella, and Boomsma et al. resulted in good performance of all three models, with an AUC ranging from 0.76 to 0.78. Our newly developed NTCP model was based on baseline TSH and baseline ferritin. Model performance was good, receiving an AUC of 0.76 (95% CI: 0.61–0.87), with a sensitivity of 57.1% and specificity of 96.9% calculated for a Youden index of 0.73 (p = 0.004; area = 0.5). Baseline TSH and ferritin act as independent predictors for radiotherapy-associated hypothyroidism. The exclusion of such laboratory chemistry parameters in future NTCP models may result in poor model performance.",{"EN":1788},"The impact of nutritional counseling on thyroid disorders in head and neck cancer patients after (chemo)radiotherapy: results from a prospective interventional trial",{"VOID":373},{"EN":1791},"",{"VOID":1793},"Jereczek-Fossa BA, Alterio D, Jassem J et al (2004) Radiotherapy-induced thyroid disorders. Cancer Treat Rev 30:369–384\nZhou L, Chen J, Tao C‑J et al (2021) Research progress of radiation-induced hypothyroidism in head and neck cancer. J Cancer 12:451–459\nHancock SL, McDougall IR, Constine LS (1995) Thyroid abnormalities after therapeutic external radiation. Int J Radiat Oncol Biol Phys 31:1165–1170\nEmami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21(1):109–122\nFujiwara M, Kamikonya N, Odawara S et al (2015) The threshold of hypothyroidism after radiation therapy for head and neck cancer: a retrospective analysis of 116 cases. J Radiat Res 56:577–582\nKim MY, Yu T, Wu H‑G (2014) Dose-volumetric parameters for predicting hypothyroidism after radiotherapy for head and neck cancer. Jpn J Clin Oncol 44:331–337\nBoomsma MJ, Bijl HP, Christianen ME et al (2012) A prospective cohort study on radiation-induced hypothyroidism: development of an NTCP model. Int J Radiat Oncol Biol Phys 84:e351–6\nDiaz R, Jaboin JJ, Morales-Paliza M et al (2010) Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 77:468–476\nRayman MP (2019) Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. Proc Nutr Soc 78:34–44\nHu S, Rayman MP (2017) Multiple nutritional factors and the risk of Hashimoto’s thyroiditis. Thyroid 27:597–610\nDunn JT, Dunn AD (2001) Update on intrathyroidal iodine metabolism. Thyroid 11:407–414\nHess SY, Zimmermann MB, Arnold M et al (2002) Iron deficiency anemia reduces thyroid peroxidase activity in rats. J Nutr 132:1951–1955\nLuo J, Wang X, Yuan L et al (2021) Iron deficiency, a risk factor of thyroid disorders in reproductive-age and pregnant women: a systematic review and meta-analysis. Front Endocrinol (Lausanne) 12:629831\nVentura M, Melo M, Carrilho F (2017) Selenium and thyroid disease: from pathophysiology to treatment. Int J Endocrinol 2017:1297658\nTahara Y, Hirota M, Shima K et al (1988) Primary hypothyroidism in an adult patient with protein-calorie malnutrition: a study of its mechanism and the effect of amino acid deficiency. Metabolism 37:9–14\nUnsal D, Mentes B, Akmansu M et al (2006) Evaluation of nutritional status in cancer patients receiving radiotherapy: a prospective study. Am J Clin Oncol 29:183–188\nLangius JAE, Doornaert P, Spreeuwenberg MD et al (2010) Radiotherapy on the neck nodes predicts severe weight loss in patients with early stage laryngeal cancer. Radiat Oncol 97:80–85\nGorenc M, Kozjek NR, Strojan P (2015) Malnutrition and cachexia in patients with head and neck cancer treated with (chemo)radiotherapy. Rep Pract Oncol Radiother 20:249–258\nKinclová I, Hajtmanová E, Matula P et al (2020) Model-based calculation of thyroid gland normal tissue complication probability in head and neck cancer patients after radiation therapy. Strahlenther Onkol 196:561–568\nLöser A, Abel J, Kutz LM et al (2021) Head and neck cancer patients under (chemo-)radiotherapy undergoing nutritional intervention: results from the prospective randomized HEADNUT-trial. Radiat Oncol 159:82–90\nKohli K, Corns R, Vinnakota K et al (2018) A bioimpedance analysis of head-and-neck cancer patients undergoing radiotherapy. Curr Oncol 25:e193–e199\nSchutz Y, Kyle UUG, Pichard C (2002) Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y. Int J Obes Relat Metab Disord 26:953–960\nSiddiqui NI, Khan SA, Shoeb M et al (2016) Anthropometric predictors of bio-impedance analysis (BIA) phase angle in healthy adults. J Clin Diagn Res 10:CC1–4\nGrundmann O, Yoon SL, Williams JJ (2015) The value of bioelectrical impedance analysis and phase angle in the evaluation of malnutrition and quality of life in cancer patients—a comprehensive review. Eur J Clin Nutr 69:1290–1297\nMayo CS, Moran JM, Bosch W et al (2018) American association of physicists in medicine task group 263: standardizing nomenclatures in radiation oncology. Int J Radiat Oncol Biol Phys 100:1057–1066\nGrégoire V, Grau C, Lapeyre M et al (2018) Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma. Oral Oncol 87:131–137\nJensen K, Friborg J, Hansen CR et al (2020) The Danish head and neck cancer group (DAHANCA) 2020 radiotherapy guidelines. Radiat Oncol 151:149–151\nRønjom MF, Brink C, Bentzen SM et al (2013) Hypothyroidism after primary radiotherapy for head and neck squamous cell carcinoma: normal tissue complication probability modeling with latent time correction. Radiat Oncol 109:317–322\nCella L, Liuzzi R, Conson M et al (2012) Development of multivariate NTCP models for radiation-induced hypothyroidism: a comparative analysis. Radiat Oncol 7:224\nSteyerberg EW, Vickers AJ, Cook NR et al (2010) Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology 21:128–138\nCutright D, Gopalakrishnan M, Roy A et al (2018) DVH analytics: a DVH database for clinicians and researchers. J Appl Clin Med Phys 19:413–427\nZimmermann MB, Burgi H, Hurrell RF (2007) Iron deficiency predicts poor maternal thyroid status during pregnancy. J Clin Endocrinol Metab 92:3436–3440\nGulhar R, Ashraf MA, Jialal I (2020) Physiology, acute phase reactants. https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fbooks\u002FNBK519570\u002F. Accessed 24 Apr 2021\nLuo R, Wu VWC, He B et al (2018) Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients. BMC Cancer 18:575\nJovanovic BD, Levy PS (1997) A look at the rule of three. Am Stat 51:137–139\nCONsolidated Standards Of Reporting Trials (2020) The CONSORT flow diagram. http:\u002F\u002Fwww.consort-statement.org\u002Fconsort-statement\u002Fflow-diagram. 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In a retrospective analysis we compared conventional radiotherapy and stereotactically guided conformal radiotherapy (SCRT) in patients with esthesioneuroblastoma. \n\n                        Patients and Methods: Between 1991 and 1999 14 patients with esthesioneuroblastoma underwent radiotherapy at our institution. Median follow-up was 30 months (range 12–107 months). Treatment included adjuvant radiotherapy (9), adjuvant radiochemotherapy (3) or radiotherapy alone (2). Eight patients received SCRT with 3-D treatment planning. For comparison a standard three-field plan for these patients and dose-volume histogram analyses were performed. Median total dose was 64 Gy using SCRT and 56 Gy with standard technique. \n\n                        Results: Local tumor control rate was 50% with conventional radiotherapy and 75% with SCRT. Overall survival was 33.3% and 62.5%, respectively. Target coverage could be improved statistically significant (p \u003C 0.05) and dose to critical structures was reduced using SCRT. Greatest differences were seen regarding volume above the 30%-isodose as well as mean dose of brain stem (p \u003C 0.05). A reduction of maximum dose was seen using SCRT as consequence of a more homogeneous treatment. \n\n                        Conclusions: SCRT improves target coverage and sparing of organs at risk. Our clinical data although with low patient numbers suggest that the technical advantage translates into a clinical advantage. The use of SCRT appears to facilitate higher dose prescriptions without risking major acute and late side effects. Thus the risk of complications in this area is minimized. 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