[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_7be5852c-4400-4f50-802b-b6f01d675c8b":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:7be5852c-4400-4f50-802b-b6f01d675c8b,\"}":163},{"code":4,"data":5,"meta":18},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":20,"manageAffiliations":33,"indexDatabases":48,"url":18,"thumbnailPath":18,"statistic":84,"gsStatistic":18,"type":18,"analyzePriority":18},"7be5852c-4400-4f50-802b-b6f01d675c8b","2024-04-15T04:46:51.933+00:00","2025-11-21T10:00:34.166+00:00",[],"Springer-Science-and-Business-Media-LLC",{"title":12,"eissn":14},{"EN":13},"Springer Science and Business Media LLC",{"VOID":15},"1746-6148","PUBLISHER","PENDING",null,0,[21,27],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":23,"label":24,"description":26,"parentId":18,"standard":18,"scholarHubFieldId":18},"1b8966b6-0f58-4173-a6fb-1b1d15827c41",[],{"EN":25},"Veterinary (miscellaneous)",{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":29,"label":30,"description":32,"parentId":18,"standard":18,"scholarHubFieldId":18},"0254e3e5-c28d-4a33-83da-81bc94d29ffd",[],{"EN":31},"Medicine (miscellaneous)",{},[34,41],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":36,"slug":18,"properties":37,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":40,"statistic":18},"67883518-0c98-470e-b6b0-160ab49bb03d",[],{"title":38},{"EN":39},"BMC",[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":43,"slug":18,"properties":44,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":47,"statistic":18},"c5894808-4e99-4047-bbce-594f58821845",[],{"title":45},{"EN":46},"BioMed Central Ltd.",[],[49,67],{"id":50,"indexDatabase":51,"url":61,"indexYears":62,"academicFieldIds":63,"indexDatabaseRanking":66},"825eee4c-5487-46ce-b87b-fa42e1d6d0fd",{"id":52,"createTime":18,"updateTime":18,"relativeEntities":53,"label":54,"description":56,"key":58,"publicationTags":59,"standard":18},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9",[],{"EN":55,"VI":55},"Scopus - Elsevier",{"EN":55,"VI":57},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[60],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F4300151401","2005-2025",[64,65],"a7b8e12d-cef0-435a-acd5-a8a5e4739725","e89cebf4-fecf-4b74-8ab4-88fca891e4c2","SCOPUS__Q2",{"id":68,"indexDatabase":69,"url":81,"indexYears":18,"academicFieldIds":82,"indexDatabaseRanking":18},"82e857a0-05de-4f8a-80eb-e1c0e919eec6",{"id":70,"createTime":18,"updateTime":18,"relativeEntities":71,"label":72,"description":74,"key":77,"publicationTags":78,"standard":18},"a4921856-b128-4d9f-8f1f-e80813d3bbd4",[],{"EN":73,"VI":73},"ISI\u002FSCIE - Science Citation Index Expanded",{"EN":75,"VI":76},"SCIE database","Cơ sở dữ liệu SCIE","scie",[79,80],"SCIE","ISI","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002Fnull",[83],"e57d1dec-8969-4f5f-83ae-545f38e03ed9",{"impactFactor":19,"impactFactorByYear":85,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":100,"totalCitation":121,"totalCitationByYear":122,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":143,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},0.04,0.32,0.3,0.36,0.42,0.39,0.38,0.4,0.57,0.41,0.5,288,56,3201,{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},7,30,26,34,29,38,50,170,168,224,204,203,266,284,299,322,252,273,158,62,9170,{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},96,287,278,122,286,250,212,658,838,1070,834,785,670,1066,619,521,282,128,1,2.86,{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},13.71,9.57,10.69,3.59,9.86,6.58,4.24,3.87,4.99,4.78,4.09,2.52,3.75,2.07,1.62,1.12,0.47,0.01,42,{"meta":164,"data":166},{"total":165},"3207",[167,596,918,1070,1335,1469,1658,1875,2075,2288],{"id":168,"createTime":169,"updateTime":170,"relativeEntities":171,"slug":172,"properties":173,"entityType":185,"verifyStatus":186,"verifyTime":187,"verifyNote":188,"languages":189,"translateLanguages":191,"viewCount":19,"primaryUrl":193,"fullTextUrl":18,"authors":194,"publicationType":289,"publisherRelationship":290,"citationCount":19,"citationInfo":341,"publishDate":18,"publishYear":18,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":343,"openAccess":18,"references":344,"isForceReanalyzing":595},"71c00fb8-dfb5-456d-a2be-62324f8f86a8","2024-04-18T23:15:41.385+00:00","2026-09-05T08:12:25.005+00:00",[],"A-Cryptosporidium-parvum-vaccine-candidate-effect-on-immunohistochemical-profiling-of-CD4-CD8-Caspase-3-and-NF-%CE%BAB-in-mice",{"openalex":174,"abstract":176,"title":178,"pm":181,"doi":183},{"VOID":175},"W4387782728",{"EN":177},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\n                \u003Cjats:title>Background\u003C\u002Fjats:title>\n                \u003Cjats:p>\u003Cjats:italic>Cryptosporidium parvum\u003C\u002Fjats:italic> is a protozoan parasite of medical and veterinary importance that causes neonatal diarrhea in many vertebrate hosts. In this study, we evaluated the efficacy of an affinity-purified antigen as a \u003Cjats:italic>C. parvum\u003C\u002Fjats:italic> vaccine candidate using ileal and liver tissues of experimentally infected neonatal mice by immunohistochemical profiling and immune scoring of CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>, CD8\u003Cjats:sup>+\u003C\u002Fjats:sup>, Caspase-3, and nuclear factor kappa B (NF-κB). This vaccine was prepared from the \u003Cjats:italic>C. parvum\u003C\u002Fjats:italic> oocysts antigen using immune affinity chromatography with cyanogen bromide-activated Sepharose-4B beads.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Methods\u003C\u002Fjats:title>\n                \u003Cjats:p>Thirty neonatal mice were divided into three groups (10 mice\u002Fgroup): (1) non-immunized non-infected, (2) non-immunized infected (using gastric tubes with a single dose of 1 × 10\u003Cjats:sup>5\u003C\u002Fjats:sup> of \u003Cjats:italic>C. parvum\u003C\u002Fjats:italic> oocysts in 250 µl PBS solution 1 h before a meal) and (3) immunized (twice with 40 µg\u002Fkg of purified \u003Cjats:italic>C. parvum\u003C\u002Fjats:italic> antigen at 2-week intervals and then infected with 1 × 10\u003Cjats:sup>5\u003C\u002Fjats:sup> \u003Cjats:italic>C. parvum\u003C\u002Fjats:italic> oocysts simultaneously with the second group). After euthanizing the animals on the 10th day, post-infection, their ileal and liver tissues were collected and prepared for immunohistochemistry (IHC) staining to detect CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>, CD8+, Caspase-3, and NF-κB levels, which are indicators for T helper cells, cytotoxic T cells, apoptosis, and inflammation, respectively.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Results\u003C\u002Fjats:title>\n                \u003Cjats:p>The IHC results showed that CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>, CD8\u003Cjats:sup>+\u003C\u002Fjats:sup>, Caspase-3, and NF-κB expression varied significantly (\u003Cjats:italic>P <\u003C\u002Fjats:italic> 0.001) in both organs in all the groups. We also recorded high CD4\u003Cjats:sup>+\u003C\u002Fjats:sup> levels and low CD8\u003Cjats:sup>+\u003C\u002Fjats:sup> expression in the non-immunized non-infected mice tissues, while the opposite was observed in the non-immunized infected mice tissues. In the immunized infected mice, the CD4\u003Cjats:sup>+\u003C\u002Fjats:sup> level was higher than CD8 + in both organs. While the Caspase-3 levels were higher in the ileal tissue of non-immunized infected than immunized infected mice ileal tissues, the reverse was seen in the liver tissues of both groups. Furthermore, NF-κB expression was higher in the liver tissues of non-immunized infected mice than in immunized infected mice tissues. Therefore, the IHC results and immune-scoring program revealed a significant difference (\u003Cjats:italic>P <\u003C\u002Fjats:italic> 0.001) in the CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>, CD8+, Caspase-3, and NF-κB expression levels in both ileal and liver tissues of all mice groups, which might be necessary for immunomodulation in these tissues.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n                \u003Cjats:p>The improvement observed in the immunized infected mice suggests that this vaccine candidate might protect against cryptosporidiosis.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>",{"EN":179,"VI":180},"A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4+, CD8+, Caspase-3 and NF-κB in mice","Tác động của một ứng viên vaccine Cryptosporidium parvum lên hồ sơ hóa mô miễn dịch của CD4+, CD8+, Caspase-3 và NF-κB ở chuột nhắt",{"VOID":182},"37858196",{"VOID":184},"10.1186\u002Fs12917-023-03699-w","PUBLICATION","VERIFIED","2025-01-27T01:55:52.152+00:00","Auto Verify",[190],"EN",[192],"VI","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-023-03699-w",[195,214,231,251,271],{"id":196,"sortIndex":19,"researcher":18,"roles":197,"affiliations":198,"properties":207,"displayName":211,"givenName":18,"familyName":18},"69a20628-d509-4284-9100-361c5e68d13c",[],[199],{"id":200,"sortIndex":19,"affiliation":201,"properties":18},"368ab8a2-d1c7-4aed-875b-d9f21cb8adfc",{"id":200,"createTime":18,"updateTime":18,"relativeEntities":202,"slug":18,"properties":203,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":206,"statistic":18},[],{"title":204},{"EN":205},"Department of Parasitology and Animal Diseases, Veterinary Research Institute, National Research Centre, Dokki, Egypt",[],{"orcid":208,"title":210,"openalex":212},{"VOID":209},"https:\u002F\u002Forcid.org\u002F0000-0002-2581-6503",{"EN":211},"Dina Aboelsoued",{"VOID":213},"A5026067041",{"id":215,"sortIndex":141,"researcher":18,"roles":216,"affiliations":217,"properties":224,"displayName":228,"givenName":18,"familyName":18},"87d310ac-5593-4b73-b328-008a79651b8d",[],[218],{"id":200,"sortIndex":19,"affiliation":219,"properties":18},{"id":200,"createTime":18,"updateTime":18,"relativeEntities":220,"slug":18,"properties":221,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":223,"statistic":18},[],{"title":222},{"EN":205},[],{"orcid":225,"title":227,"openalex":229},{"VOID":226},"https:\u002F\u002Forcid.org\u002F0000-0002-9718-5130",{"EN":228},"Nagwa I. Toaleb",{"VOID":230},"A5027769457",{"id":232,"sortIndex":233,"researcher":18,"roles":234,"affiliations":235,"properties":244,"displayName":248,"givenName":18,"familyName":18},"c085f729-31ba-4f07-8f87-8c8e2985bdd4",2,[],[236],{"id":237,"sortIndex":19,"affiliation":238,"properties":18},"799aa40b-acd2-4fef-bc25-12cc2b2e63c7",{"id":237,"createTime":18,"updateTime":18,"relativeEntities":239,"slug":18,"properties":240,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":243,"statistic":18},[],{"title":241},{"EN":242},"Department of Animal Reproduction and AI, Veterinary Research Institute, National Research Centre, Dokki, Egypt",[],{"orcid":245,"title":247,"openalex":249},{"VOID":246},"https:\u002F\u002Forcid.org\u002F0000-0003-2098-6463",{"EN":248},"Sally Ibrahim",{"VOID":250},"A5021413764",{"id":252,"sortIndex":253,"researcher":18,"roles":254,"affiliations":255,"properties":264,"displayName":268,"givenName":18,"familyName":18},"5e38bf8e-c519-43ea-a4d4-323babc99b3b",3,[],[256],{"id":257,"sortIndex":19,"affiliation":258,"properties":18},"76f5552c-1bfa-4732-bb60-67162bd4b40b",{"id":257,"createTime":18,"updateTime":18,"relativeEntities":259,"slug":18,"properties":260,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":263,"statistic":18},[],{"title":261},{"EN":262},"Department of Zoonotic Diseases, Veterinary Research Institute, National Research Centre, Dokki, Egypt",[],{"orcid":265,"title":267,"openalex":269},{"VOID":266},"https:\u002F\u002Forcid.org\u002F0000-0002-2620-4189",{"EN":268},"Raafat M. Shaapan",{"VOID":270},"A5007225353",{"id":272,"sortIndex":273,"researcher":18,"roles":274,"affiliations":275,"properties":282,"displayName":286,"givenName":18,"familyName":18},"577c1508-1119-44ca-b58e-7d53ea3e2761",4,[],[276],{"id":200,"sortIndex":19,"affiliation":277,"properties":18},{"id":200,"createTime":18,"updateTime":18,"relativeEntities":278,"slug":18,"properties":279,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":281,"statistic":18},[],{"title":280},{"EN":205},[],{"orcid":283,"title":285,"openalex":287},{"VOID":284},"https:\u002F\u002Forcid.org\u002F0000-0002-0723-7276",{"EN":286},"Kadria N. Abdel Megeed",{"VOID":288},"A5086940140","ARTICLE",{"url":18,"publisher":291,"properties":336},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":292,"slug":10,"properties":293,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":296,"manageAffiliations":305,"indexDatabases":316,"url":18,"thumbnailPath":18,"statistic":331,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":294,"eissn":295},{"EN":13},{"VOID":15},[297,301],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":298,"label":299,"description":300,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":302,"label":303,"description":304,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[306,311],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":307,"slug":18,"properties":308,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":310,"statistic":18},[],{"title":309},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":312,"slug":18,"properties":313,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":315,"statistic":18},[],{"title":314},{"EN":46},[],[317,324],{"id":50,"indexDatabase":318,"url":61,"indexYears":62,"academicFieldIds":323,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":319,"label":320,"description":321,"key":58,"publicationTags":322,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":325,"url":81,"indexYears":18,"academicFieldIds":330,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":326,"label":327,"description":328,"key":77,"publicationTags":329,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":332,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":333,"totalCitation":121,"totalCitationByYear":334,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":335,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"issue":337,"volume":339},{"VOID":338},"1",{"VOID":340},"19",{"total":19,"publishYear":18,"statisticByYear":342},{},[],[345,349,353,357,361,365,369,373,377,381,385,389,393,397,401,405,409,413,417,421,425,429,433,437,441,445,449,453,457,461,465,469,473,476,480,484,488,492,496,500,504,508,512,516,520,524,528,532,536,540,544,548,552,556,560,564,568,572,576,580,584,588,591],{"id":18,"text":346,"url":18,"identifiers":347},"Ghazy AA, Abdel-Shafy S, Shaapan RM. Cryptosporidiosis in animals and man: 1. Taxonomic classification, life cycle, epidemiology and zoonotic importance. As J Epidemiol. 2015;8(3):48–63. https:\u002F\u002Fdoi.org\u002F10.3923\u002Faje.2015.48.63",{"doi":348},"10.3923\u002Faje.2015.48.63",{"id":18,"text":350,"url":18,"identifiers":351},"Aboelsoued D, Abdel Megeed KN. Diagnosis and control of cryptosporidiosis in farm animals. J Parasit Dis. 2022;46:1133–46. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12639-022-01513-2",{"doi":352},"10.1007\u002Fs12639-022-01513-2",{"id":18,"text":354,"url":18,"identifiers":355},"Ghazy AA, Abdel-Shafy S, Shaapan RM. Cryptosporidiosis in animals and man: 3. Prev Control as J Epidemiol. 2016;9(1–3):1–9. https:\u002F\u002Fdoi.org\u002F10.3923\u002Faje.2016.1.9",{"doi":356},"10.3923\u002Faje.2016.1.9",{"id":18,"text":358,"url":18,"identifiers":359},"Gaber M, Galal LAA, Hassan D, Badary DM, et al. Evidences of brain and lung invasion of a local water Cryptosporidium parvum isolate in comparison to Iowa strain: serological and immunohistochemical cytokine evaluation. Ann Parasitol. 2020;66(3):311–8. https:\u002F\u002Fdoi.org\u002F10.17420\u002Fap6603.269",{"doi":360},"10.17420\u002Fap6603.269",{"id":18,"text":362,"url":18,"identifiers":363},"Deng M, Rutherford MS, Abrahamsen MS. Host intestinal epithelial response to Cryptosporidium parvum. Adv Drug Deliv Rev. 2004;56(6):869–84. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.addr.2003.10.034",{"doi":364},"10.1016\u002Fj.addr.2003.10.034",{"id":18,"text":366,"url":18,"identifiers":367},"Laurent F, Lacroix-Lamandé S. Innate immune responses play a key role in controlling infection of the intestinal epithelium by Cryptosporidium. Int J Parasitol. 2017;47:711–21. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijpara.2017.08.001",{"doi":368},"10.1016\u002Fj.ijpara.2017.08.001",{"id":18,"text":370,"url":18,"identifiers":371},"Riggs MW. Recent advances in cryptosporidiosis: the immune response. Microbes Infect. 2002;4(10):1067–80. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs1286-4579(02)01631-3",{"doi":372},"10.1016\u002Fs1286-4579(02)01631-3",{"id":18,"text":374,"url":18,"identifiers":375},"Ludington JG, Ward HD. Systemic and mucosal immune responses to cryptosporidium—vaccine development. Curr Trop Med Rep. 2015;2(3):171–80. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs40475-015-0054-y",{"doi":376},"10.1007\u002Fs40475-015-0054-y",{"id":18,"text":378,"url":18,"identifiers":379},"O’Hara SP, Bogert PS, Trussoni CE, Chen X, LaRusso NF. TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis. J Parasitol. 2011;97(5):813–21. https:\u002F\u002Fdoi.org\u002F10.1645\u002FGE-2703.1",{"doi":380},"10.1645\u002FGE-2703.1",{"id":18,"text":382,"url":18,"identifiers":383},"Gomez Morales MA, Mele R, Ludovisi A, Bruschi F, Tosini F, Pozio E. Cryptosporidium parvum-specific CD4+ Th1 cells from sensitized donors responding to both fractionated and recombinant antigenic proteins. Infect Immun. 2004;72(3):1306–10. https:\u002F\u002Fdoi.org\u002F10.1128\u002FIAI.72.3.1306-1310.2004",{"doi":384},"10.1128\u002FIAI.72.3.1306-1310.2004",{"id":18,"text":386,"url":18,"identifiers":387},"Pantenburg B, Castellanos-Gonzalez A, Dann SM, Connelly RL, Lewis DE, Ward HD, White AC Jr. Human CD8+ T cells clear Cryptosporidium parvum from infected intestinal epithelial cells. The Am J Trop Med Hyg. 2010;82(4):600–7. https:\u002F\u002Fdoi.org\u002F10.4269%2Fajtmh.2010.09-0590.",{"doi":388},"10.4269\u002Fajtmh.2010.09-0590",{"id":18,"text":390,"url":18,"identifiers":391},"Kváč M, Kodadkova A, Sak B, Kvetonova D, Jalovecka M, Rost M, et al. Activated CD8+ T cells contribute to clearance of gastric Cryptosporidium muris infections. Parasite Immunol. 2011;33(4):210–6. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1365-3024.2010.01271.x",{"doi":392},"10.1111\u002Fj.1365-3024.2010.01271.x",{"id":18,"text":394,"url":18,"identifiers":395},"Leav BA, Yoshida M, Rogers K, Cohen S, Godiwala N, Blumberg RS, Ward H. An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice. Infect Immun. 2005;73(12):8425–8. https:\u002F\u002Fdoi.org\u002F10.1128\u002FIAI.73.12.8425-8428.2005",{"doi":396},"10.1128\u002FIAI.73.12.8425-8428.2005",{"id":18,"text":398,"url":18,"identifiers":399},"Shale M, Schiering C, Powrie F. CD4(+) T-cell subsets in intestinal inflammation. Immunol Rev. 2013;252(1):164–82. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fimr.12039",{"doi":400},"10.1111\u002Fimr.12039",{"id":18,"text":402,"url":18,"identifiers":403},"Sathaliyawala T, Kubota M, Yudanin N, Turner D, Camp P, Thome JJ, et al. Dis- tribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity. 2013;38(1):187–97. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.immuni.2012.09.020",{"doi":404},"10.1016\u002Fj.immuni.2012.09.020",{"id":18,"text":406,"url":18,"identifiers":407},"Turner DL, Bickham KL, Thome JJ, Kim CY, D’Ovidio F, Wherry EJ et al. Lung niches for the generation and maintenance of tissue-resident memory T cells. Mucosal Immunol 2014.7(3):501–10. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fmi.2013.67",{"doi":408},"10.1038\u002Fmi.2013.67",{"id":18,"text":410,"url":18,"identifiers":411},"Turner DL, Farber DL. Mucosal resident memory CD4+ T cells in protection and immunopathology. Front Immunol. 2014;14(5):331. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffimmu.2014.00331",{"doi":412},"10.3389\u002Ffimmu.2014.00331",{"id":18,"text":414,"url":18,"identifiers":415},"McCole DF, Eckmann L, Laurent F, Kagnoff MF. Intestinal epithelial cell apoptosis following Cryptosporidium parvum infection. Infect Immun. 2000;68(3):1710–3. https:\u002F\u002Fdoi.org\u002F10.1128\u002FIAI.68.3.1710-1713.2000",{"doi":416},"10.1128\u002FIAI.68.3.1710-1713.2000",{"id":18,"text":418,"url":18,"identifiers":419},"Green DR. Apoptotic pathways: ten minutes to dead. Cell. 2005;121(5):671–4. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cell.2005.05.019",{"doi":420},"10.1016\u002Fj.cell.2005.05.019",{"id":18,"text":422,"url":18,"identifiers":423},"Liu J, Enomoto S, Lancto CA, Abrahamsen MS, Rutherford MS. Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin. Infect Immun. 2008;76(8):3784–92. https:\u002F\u002Fdoi.org\u002F10.1128\u002FIAI.00308-08",{"doi":424},"10.1128\u002FIAI.00308-08",{"id":18,"text":426,"url":18,"identifiers":427},"Shi Y. Caspase activation: revisiting the induced proximity model. Cell. 2004; 25;117(7):855-8. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cell.2004.06.007",{"doi":428},"10.1016\u002Fj.cell.2004.06.007",{"id":18,"text":430,"url":18,"identifiers":431},"Goyal L. Cell death inhibition: keeping caspases in check. Cell. 2001;104(6):805–8. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0092-8674(01)00276-8",{"doi":432},"10.1016\u002FS0092-8674(01)00276-8",{"id":18,"text":434,"url":18,"identifiers":435},"Bosurgi L, Rothlin CV. Management of cell death in parasitic infections. Semin Immunopathol. 2021;43(4):481–92. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00281-021-00875-8",{"doi":436},"10.1007\u002Fs00281-021-00875-8",{"id":18,"text":438,"url":18,"identifiers":439},"Chen XM, Levine SA, Splinter PL, Tietz PS, Ganong AL, Jobin C, Gores GJ, Paya CV, LaRusso NF. Cryptosporidium parvum activates nuclear factor κB in biliary epithelia preventing epithelial cell apoptosis. Gastroenterology. 2001;120(7):1774–83. https:\u002F\u002Fdoi.org\u002F10.1053\u002Fgast.2001.24850",{"doi":440},"10.1053\u002Fgast.2001.24850",{"id":18,"text":442,"url":18,"identifiers":443},"Mele R, Gomez Morales MA, Tosini F, Pozio E. Cryptosporidium parvum at different developmental stages modulates host cell apoptosis in vitro. Infect Immun. 2004;72(10):6061–7. https:\u002F\u002Fdoi.org\u002F10.1128\u002FIAI.72.10.6061-6067.2004",{"doi":444},"10.1128\u002FIAI.72.10.6061-6067.2004",{"id":18,"text":446,"url":18,"identifiers":447},"Orange JS, Levy O, Geha RS. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-κB activation. Immunol Rev. 2005;203(1):21–37. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.0105-2896.2005.00221.x",{"doi":448},"10.1111\u002Fj.0105-2896.2005.00221.x",{"id":18,"text":450,"url":18,"identifiers":451},"Liu J, Deng M, Lancto CA, Abrahamsen MS, Rutherford MS, Enomoto S. Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cells. Infect Immun. 2009;77(2):837–49. https:\u002F\u002Fdoi.org\u002F10.1128\u002FIAI.00955-08",{"doi":452},"10.1128\u002FIAI.00955-08",{"id":18,"text":454,"url":18,"identifiers":455},"Lalaoui N, Vaux DL. Recent advances in understanding inhibitor of apoptosis proteins. F1000Research. 2018;F1000Res(7). https:\u002F\u002Fdoi.org\u002F10.12688%2Ff1000research.16439.1.",{"doi":456},"10.12688\u002Ff1000research.16439.1",{"id":18,"text":458,"url":18,"identifiers":459},"Carmen JC, Sinai AP. Suicide prevention: disruption of apoptotic pathways by protozoan parasites. Mol Microbiol. 2007;64(4):904–. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1365-2958.2007.05714.x. 16.",{"doi":460},"10.1111\u002Fj.1365-2958.2007.05714.x",{"id":18,"text":462,"url":18,"identifiers":463},"O’Hara SP, Chen XM. The cell biology of Cryptosporidium infection. Microbes Infect. 2011;13(8–9):721–30. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.micinf.2011.03.008",{"doi":464},"10.1016\u002Fj.micinf.2011.03.008",{"id":18,"text":466,"url":18,"identifiers":467},"Aboelsoued D, Hendawy S, Abdullah HH, Abdel Megeed KN, Hassan SE, El Hakim AE, Toaleb NI. Diagnosis of Cryptosporidiosis using Affinity purified Antigen. Egyp J Vet Sci. 2022;53(3):459–73. https:\u002F\u002Fdoi.org\u002F10.21608\u002Fejvs.2022.145814.1354",{"doi":468},"10.21608\u002Fejvs.2022.145814.1354",{"id":18,"text":470,"url":18,"identifiers":471},"Aboelsoued D, Abdullah HHAM, Abdel Megeed KN, Hassan SE, Toaleb NI. Evaluation of a vaccine candidate isolated from Cryptosporidium parvum oocyst in mice. Accepted: Vet. World; 2022a.",{"doi":472},"10.14202\u002Fvetworld.2022.2772-2784",{"id":18,"text":474,"url":18,"identifiers":475},"Aly I, Taher H, El-Feky F. Efficacy of low and high dose of paromomycin sulfate for treatment of cryptosporidiosis in immunosuppressed infected-mice. Glob Vet. 2015;15:137–43. https:\u002F\u002Fwww.idosi.org\u002Fgv\u002Fgv15(2)15\u002F1.pdf",{},{"id":18,"text":477,"url":18,"identifiers":478},"Leone V, Ali A, Weber A, Tschaharganeh DF, Heikenwalder M. Liver inflammation and hepatobiliary cancers. Trends Cancer. 2021;7606–23. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.trecan.2021.01.012",{"doi":479},"10.1016\u002Fj.trecan.2021.01.012",{"id":18,"text":481,"url":18,"identifiers":482},"Fahmy MEA, Abdelaal AA, Hassan SI, Shalaby MA, et al. Antiparasitic and immunomodulating effects of nitazoxanide, ivermectin and selenium on Cryptosporidium infection in diabetic mice. Braz J Vet Parasitol. 2021;30(4):e012121. https:\u002F\u002Fdoi.org\u002F10.1590\u002FS1984-29612021087",{"doi":483},"10.1590\u002FS1984-29612021087",{"id":18,"text":485,"url":18,"identifiers":486},"Tauschmann M, Prietl B, Treiber G, Gorkiewicz G, et al. Distribution of CD4+ pos - CD8+ pos and regulatory T cells in the upper and lower gastrointestinal tract in healthy young subjects. PLoS ONE. 2013;8(11):e80362. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0080362",{"doi":487},"10.1371\u002Fjournal.pone.0080362",{"id":18,"text":489,"url":18,"identifiers":490},"Tinarwo P, Zewotir T, North D. Trends and adaptive optimal set points of CD4+ count clinical covariates at each phase of the HIV disease progression. Aids Res Treat. 2020;2020:1379676. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2020\u002F1379676",{"doi":491},"10.1155\u002F2020\u002F1379676",{"id":18,"text":493,"url":18,"identifiers":494},"Wang Z, Wang Y, Xu B, Liu J, et al. Vitamin D improves immune function in immunosuppressant mice induced by glucocorticoid. Biomed Rep. 2017;6(1):120–24. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fbr.2016.817",{"doi":495},"10.3892\u002Fbr.2016.817",{"id":18,"text":497,"url":18,"identifiers":498},"Tessema TS, Dauber E, Petry F. Adoptive transfer of protective immunity from Cryptosporidium parvum-infected interferon-γ and interleukin-12-deficient mice to naive recipients. Vaccine. 2009;27(47):6575–81. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vaccine.2009.08.036",{"doi":499},"10.1016\u002Fj.vaccine.2009.08.036",{"id":18,"text":501,"url":18,"identifiers":502},"Uchiyama R, Tsutsui H. Caspases as the key effectors of inflammatory responses against bacterial infection. Arch Immunol Ther Exp. 2015;63(1):1–3. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00005-014-0301-2",{"doi":503},"10.1007\u002Fs00005-014-0301-2",{"id":18,"text":505,"url":18,"identifiers":506},"Samaka RM, El Shafei OK, Harba NM, Farag SA, Sharaf OF. Role of apoptosis in experimental Cryptosporidium parvum infected albino mice. Journal of the Egyptian Society of Parasitology. 2021;51(1):89–98. https:\u002F\u002Fjesp.journals.ekb.eg\u002Farticle_165944_dbb99eb2b35c8c8885e67d8bd6cdd9c9.pdf.",{"doi":507},"10.21608\u002Fjesp.2021.165944",{"id":18,"text":509,"url":18,"identifiers":510},"Sasahara T, Sekiguchi T, Satoh Y, Kitasato H, Inoue M, Takayama Y, Takahashi A, Maruyama H, Aoki M, Kikuno R. Apoptosis of intestinal crypt epithelium after Cryptosporidium parvum infection. J Infect Chemother. 2003;9(3):278–81. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs10156-003-0259-1",{"doi":511},"10.1007\u002Fs10156-003-0259-1",{"id":18,"text":513,"url":18,"identifiers":514},"Buret AG, Chin AC, Scott KG. Infection of human and bovine epithelial cells with Cryptosporidium andersoni induces apoptosis and disrupts tight junctional ZO-1: effects of epidermal growth factor. Int J Parasitol. 2003;33(12):1363–71. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0020-7519(03)00138-3",{"doi":515},"10.1016\u002FS0020-7519(03)00138-3",{"id":18,"text":517,"url":18,"identifiers":518},"Payne TM, Molestina RE, Sinai AP. Inhibition of caspase activation and a requirement for NF-kappa B function in the Toxoplasma gondii-mediated blockade of host apoptosis. J Cell Sci. 2003;116(21):4345–58. https:\u002F\u002Fdoi.org\u002F10.1242\u002Fjcs.00756",{"doi":519},"10.1242\u002Fjcs.00756",{"id":18,"text":521,"url":18,"identifiers":522},"Zhang L, Zheng MX, Xi R, Xu ZY, Zhang XS, Zheng LL, Bai R, Mi CL, Hao FF, Feng YP. Comparison of the host cells apoptosis induced by precocious strains and virulent strains of Eimeria tenella. Poult Sci. 2019;98(10):4384–90. https:\u002F\u002Fdoi.org\u002F10.3382\u002Fps\u002Fpez218",{"doi":523},"10.3382\u002Fps\u002Fpez218",{"id":18,"text":525,"url":18,"identifiers":526},"Pohanka M, Vobornikova I, Fusek J. Freund´s complete adjuvant effect on BALB\u002Fc mice: an insight into inflammation and oxidative stress after immunity challenge. Bratisl Lek Listy. 2016;117(5):268–71. https:\u002F\u002Fdoi.org\u002F10.4149\u002Fbll_2016_052",{"doi":527},"10.4149\u002Fbll_2016_052",{"id":18,"text":529,"url":18,"identifiers":530},"Billiau A, Matthys P. Modes of action of Freund’s adjuvants in experimental models of autoimmune diseases. J Leukoc Biol. 2001;70(6):849–60. https:\u002F\u002Fdoi.org\u002F10.1189\u002Fjlb.70.6.849",{"doi":531},"10.1189\u002Fjlb.70.6.849",{"id":18,"text":533,"url":18,"identifiers":534},"Loison E, Poirier-Beaudouin B, Seffer V, Paoletti A, Abitbol V, Tartour E, Launay O, Gougeon ML. Suppression by thimerosal of ex-vivo CD4+ T cell response to influenza vaccine and induction of apoptosis in primary memory T cells. PLoS ONE. 2014;9(4):e92705. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0092705",{"doi":535},"10.1371\u002Fjournal.pone.0092705",{"id":18,"text":537,"url":18,"identifiers":538},"Kolářová I, Valigurová A. Hide-and-Seek: a game played between parasitic Protists and their hosts. Microorganisms. 2021;9(12):2434. https:\u002F\u002Fdoi.org\u002F10.3390\u002Fmicroorganisms9122434",{"doi":539},"10.3390\u002Fmicroorganisms9122434",{"id":18,"text":541,"url":18,"identifiers":542},"Carmen JC, Hardi L, Sinai AP. Toxoplasma gondii inhibits ultraviolet light-induced apoptosis through multiple interactions with the mitochondrion-dependent programmed cell death pathway. Cell Microbiol. 2006;8(2):301–15. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1462-5822.2005.00622.x",{"doi":543},"10.1111\u002Fj.1462-5822.2005.00622.x",{"id":18,"text":545,"url":18,"identifiers":546},"Guergnon J, Dessauge F, Langsley G, Garcia A. Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3. Biochimie. 2003;85(8):771–6. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biochi.2003.09.013",{"doi":547},"10.1016\u002Fj.biochi.2003.09.013",{"id":18,"text":549,"url":18,"identifiers":550},"Shang L, Smith A, Reilly C, et al. Vaccine-modified NF-kB and GR signaling in cervicovaginal epithelium correlates with protection. Mucosal Immunol. 2018;11:512–22. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fmi.2017.69",{"doi":551},"10.1038\u002Fmi.2017.69",{"id":18,"text":553,"url":18,"identifiers":554},"Henriksen SA, Pohlenz JF. Staining of Cryptosporidia by a modified Ziehl-Neelsen technique. Acta Vet Scand. 1981;22:594–6. https:\u002F\u002Fdoi.org\u002F10.1186\u002FBF03548684",{"doi":555},"10.1186\u002FBF03548684",{"id":18,"text":557,"url":18,"identifiers":558},"Aboelsoued D, Abo-Aziza FAM, Mahmoud MH, Abdel Megeed KN, et al. Anticryptosporidial effect of pomegranate peels water extract in experimentally infected mice with special reference to some biochemical parameters and antioxidant activity. J Parasit Dis. 2019;43(2):215–28. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12639-018-01078-z",{"doi":559},"10.1007\u002Fs12639-018-01078-z",{"id":18,"text":561,"url":18,"identifiers":562},"Hassanain MA, Khalil FA, Abd El-Razik KA, Shaapan RM. Prevalence and molecular discrimination of Cryptosporidium parvum in calves in behira provinces, Egypt. Res J Parasitol. 2011;6(3):101–8. https:\u002F\u002Fjp.2011.101.108",{"doi":563},"10.3923\u002Fjp.2011.101.108",{"id":18,"text":565,"url":18,"identifiers":566},"Shaapan RM, Abdel-Ghaffar FA, Varjabedian KG, Saad-Alla GI. Prevalence and molecular epidemiology of Cryptosporidium infection in Clarias gariepinus fish in Egypt. Acta Parasitol. 2022;67(1):437–45. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11686-021-00483-4",{"doi":567},"10.1007\u002Fs11686-021-00483-4",{"id":18,"text":569,"url":18,"identifiers":570},"Aboelsoued D, Hendawy SHM, Abo-Aziza FAM, Abdel Megeed KN. Copro-microscopical and immunological diagnosis of cryptosporidiosis in egyptian buffalo-calves with special reference to their cytokine profiles. J Parasit Dis. 2020;44(3):654–60. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12639-020-01244-2",{"doi":571},"10.1007\u002Fs12639-020-01244-2",{"id":18,"text":573,"url":18,"identifiers":574},"Fagbemi BO, Obarisiaghon IO, Mbuh JV. Detection of circulating antigen in sera of Fasciola gigantica infected cattle with antibodies reactive with a Fasciola-specific 88 kDa antigen. Vet Parasitol. 1995;58(3):235–46. https:\u002F\u002Fdoi.org\u002F10.1016\u002F0304-4017(94)00718-r",{"doi":575},"10.1016\u002F0304-4017(94)00718-r",{"id":18,"text":577,"url":18,"identifiers":578},"Toaleb NI, Gabr HSM, Abd El-Shafy S, Abdel-Rahman EH. Evaluation of vaccine candidates purified from the adult ticks of Ornithodoros savignyi (Acari: Argasidae) and Hyalomma dromedarii (Acari: Ixodidae) against tick infestations. J Parasit Dis. 2019;43(2):246–55. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12639-018-01082-3",{"doi":579},"10.1007\u002Fs12639-018-01082-3",{"id":18,"text":581,"url":18,"identifiers":582},"Lowry OH, Rosebrough NJ, Farr AB, Randall RJ. Protein measurement with the folin-phenol reagent. J Biol Chem. 1951;193:265–75.",{"doi":583},"10.1016\u002FS0021-9258(19)52451-6",{"id":18,"text":585,"url":18,"identifiers":586},"Liu K, Zai D, Zhang D, Wei Q, Han G, Gao H, Huang B. Divalent Cp15-23 vaccine enhances immune responses and protection against Cryptosporidium parvum infection. Parasite Immunol. 2010;32(5):335–44. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1365-3024.2009.01191.x",{"doi":587},"10.1111\u002Fj.1365-3024.2009.01191.x",{"id":18,"text":589,"url":18,"identifiers":590},"Bancroft JD, Stevens A. Theory and Practice of histological techniques. Churchill Livingstone, London. Edition: 2013;7th. Ed. P: 120:131.",{},{"id":18,"text":592,"url":18,"identifiers":593},"Hsu SM, Raine L, Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol. 1981;75(6):816–21. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fajcp\u002F75.6.816",{"doi":594},"10.1093\u002Fajcp\u002F75.6.816",false,{"id":597,"createTime":598,"updateTime":599,"relativeEntities":600,"slug":601,"properties":602,"entityType":185,"verifyStatus":186,"verifyTime":611,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":612,"fullTextUrl":18,"authors":613,"publicationType":289,"publisherRelationship":755,"citationCount":19,"citationInfo":806,"publishDate":809,"publishYear":807,"citationAnalyzeStatus":810,"lastCitationAnalyze":599,"indexDatabases":811,"openAccess":18,"references":812,"isForceReanalyzing":595},"33a6cecc-edc1-468b-805e-eee55ee9a316","2024-01-27T17:04:09.719+00:00","2026-08-24T13:53:07.955+00:00",[],"Postoperative-pain-and-short-term-complications-after-two-elective-sterilization-techniques-ovariohysterectomy-or-ovariectomy-in-cats",{"abstract":603,"title":605,"gsPaper":607,"doi":609},{"EN":604},"Surgical sterilization of cats is one of the most commonly performed procedures in veterinary practice and it can be accomplished by two different techniques: ovariohysterectomy (OVH) or ovariectomy (OVE). Although there is an apparent preference for OVH in United States and Canada, OVE seems to be the standard of care in many European countries due to its advantages, such as a smaller surgical incision and potentially less complications associated with surgical manipulation of the uterus. The aim of this randomized, blind, prospective study was to compare postoperative pain and short-term complications in cats undergoing ovariohysterectomy or ovariectomy. Twenty female cats were randomly assigned into two groups (OVH, n = 10 and OVE, n = 10). Pain was assessed prior to surgery (baseline) and 1, 2, 4, 8 12 and 24 h after the procedure using pain and sedation scales, physiologic parameters and blood glucose levels. Short-term complications were evaluated in the early postoperative period and reassessed at day 7 and day 10. Changes in cardiovascular parameters were not clinically relevant, however cats in OVH group had higher heart rates at T1 h compared with baseline (p = 0.0184). Blood glucose levels in OVH group were also higher at T1 h compared with baseline (p = 0.0135) and with OVE group (p = 0.0218). Surgical time was higher in OVH group (p = 0.0115). Even though no significant differences in pain scores were observed between groups or time points, cats in OVH group had greater need for rescue analgesia compared with OVE (2\u002F10 and 0\u002F10, respectively). Complications were not observed in any cat during surgery, at days 7 and 10 postoperatively or at discharge. Both surgical techniques promoted similar intensity of postoperative pain in cats and there were no short-term complications throughout the study’s evaluation period. Therefore, both techniques may be indicated for surgical sterilization of cats, according to the surgeon’s preference and expertise. Cats that underwent ovariectomy did not require rescue analgesia and surgical time was shorter in that group.",{"EN":606},"Postoperative pain and short-term complications after two elective sterilization techniques: ovariohysterectomy or ovariectomy in cats",{"VOID":608},"[\"4644397461201737638\"]",{"VOID":610},"10.1186\u002Fs12917-018-1657-z","2024-05-06T10:22:32.609+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-018-1657-z",[614,632,645,660,673,686,700,714,727,741],{"id":615,"sortIndex":19,"researcher":18,"roles":616,"affiliations":618,"properties":627,"displayName":629,"givenName":18,"familyName":18},"25fafdaa-c1dd-4992-b0ee-f28fe0d815f4",[617],"AUTHOR",[619],{"id":620,"sortIndex":19,"affiliation":621,"properties":18},"72eeed02-1059-4450-a19b-eeb4b295f15b",{"id":620,"createTime":18,"updateTime":18,"relativeEntities":622,"slug":18,"properties":623,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":626,"statistic":18},[],{"title":624},{"VI":625},"Faculty of Veterinary Medicine and Animal Sciences, Department of Surgery, University of Sao Paulo, Sao Paulo, Brazil",[],{"title":628,"gsAuthor":630},{"VI":629},"Marco Aurélio A. Pereira",{"VOID":631},"[\"K0lXXVIAAAAJ\"]",{"id":633,"sortIndex":141,"researcher":18,"roles":634,"affiliations":635,"properties":642,"displayName":644,"givenName":18,"familyName":18},"6128392c-4e5f-48e5-9357-6b065891f6b0",[617],[636],{"id":620,"sortIndex":19,"affiliation":637,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":638,"slug":18,"properties":639,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":641,"statistic":18},[],{"title":640},{"VI":625},[],{"title":643},{"VI":644},"Lucas A. Gonçalves",{"id":646,"sortIndex":233,"researcher":18,"roles":647,"affiliations":648,"properties":657,"displayName":659,"givenName":18,"familyName":18},"50916406-e77b-4561-82c6-500a17688eb0",[617],[649],{"id":650,"sortIndex":19,"affiliation":651,"properties":18},"fc2dd174-8b0a-4b74-99d8-34417d49c29a",{"id":650,"createTime":18,"updateTime":18,"relativeEntities":652,"slug":18,"properties":653,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":656,"statistic":18},[],{"title":654},{"VI":655},"Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, Quebec, Canada",[],{"title":658},{"VI":659},"Marina C. Evangelista",{"id":661,"sortIndex":253,"researcher":18,"roles":662,"affiliations":663,"properties":670,"displayName":672,"givenName":18,"familyName":18},"9c5ddd88-9117-42c9-a884-f51537af0d3d",[617],[664],{"id":620,"sortIndex":19,"affiliation":665,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":666,"slug":18,"properties":667,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":669,"statistic":18},[],{"title":668},{"VI":625},[],{"title":671},{"VI":672},"Rosana S. Thurler",{"id":674,"sortIndex":273,"researcher":18,"roles":675,"affiliations":676,"properties":683,"displayName":685,"givenName":18,"familyName":18},"6d2f7da0-6528-4ee1-9e72-84bd5f387741",[617],[677],{"id":620,"sortIndex":19,"affiliation":678,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":679,"slug":18,"properties":680,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":682,"statistic":18},[],{"title":681},{"VI":625},[],{"title":684},{"VI":685},"Karina D. Campos",{"id":687,"sortIndex":688,"researcher":18,"roles":689,"affiliations":690,"properties":697,"displayName":699,"givenName":18,"familyName":18},"dc766e3b-fcab-4f04-ae9c-a6b0c4f93edd",5,[617],[691],{"id":620,"sortIndex":19,"affiliation":692,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":693,"slug":18,"properties":694,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":696,"statistic":18},[],{"title":695},{"VI":625},[],{"title":698},{"VI":699},"Maira R. Formenton",{"id":701,"sortIndex":702,"researcher":18,"roles":703,"affiliations":704,"properties":711,"displayName":713,"givenName":18,"familyName":18},"c47b800f-dc66-42be-9c94-0288970a9079",6,[617],[705],{"id":620,"sortIndex":19,"affiliation":706,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":707,"slug":18,"properties":708,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":710,"statistic":18},[],{"title":709},{"VI":625},[],{"title":712},{"VI":713},"Geni C. F. Patricio",{"id":715,"sortIndex":101,"researcher":18,"roles":716,"affiliations":717,"properties":724,"displayName":726,"givenName":18,"familyName":18},"d64db3dc-f2c4-4c22-a4ce-be483cda9c2a",[617],[718],{"id":620,"sortIndex":19,"affiliation":719,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":720,"slug":18,"properties":721,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":723,"statistic":18},[],{"title":722},{"VI":625},[],{"title":725},{"VI":726},"Julia M. Matera",{"id":728,"sortIndex":729,"researcher":18,"roles":730,"affiliations":731,"properties":738,"displayName":740,"givenName":18,"familyName":18},"d38dc2f7-4abb-453d-9998-85999799b011",8,[617],[732],{"id":620,"sortIndex":19,"affiliation":733,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":734,"slug":18,"properties":735,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":737,"statistic":18},[],{"title":736},{"VI":625},[],{"title":739},{"VI":740},"Aline M. Ambrósio",{"id":742,"sortIndex":743,"researcher":18,"roles":744,"affiliations":745,"properties":752,"displayName":754,"givenName":18,"familyName":18},"81ae2ee4-ccf8-4b45-97e8-e458f8106498",9,[617],[746],{"id":620,"sortIndex":19,"affiliation":747,"properties":18},{"id":620,"createTime":18,"updateTime":18,"relativeEntities":748,"slug":18,"properties":749,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":751,"statistic":18},[],{"title":750},{"VI":625},[],{"title":753},{"VI":754},"Denise T. Fantoni",{"url":612,"publisher":756,"properties":801},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":757,"slug":10,"properties":758,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":761,"manageAffiliations":770,"indexDatabases":781,"url":18,"thumbnailPath":18,"statistic":796,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":759,"eissn":760},{"EN":13},{"VOID":15},[762,766],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":763,"label":764,"description":765,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":767,"label":768,"description":769,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[771,776],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":772,"slug":18,"properties":773,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":775,"statistic":18},[],{"title":774},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":777,"slug":18,"properties":778,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":780,"statistic":18},[],{"title":779},{"EN":46},[],[782,789],{"id":50,"indexDatabase":783,"url":61,"indexYears":62,"academicFieldIds":788,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":784,"label":785,"description":786,"key":58,"publicationTags":787,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":790,"url":81,"indexYears":18,"academicFieldIds":795,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":791,"label":792,"description":793,"key":77,"publicationTags":794,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":797,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":798,"totalCitation":121,"totalCitationByYear":799,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":800,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"pages":802,"volume":804},{"VOID":803},"1-7",{"VOID":805},"14",{"total":19,"publishYear":807,"statisticByYear":808},2018,{},"2018-11-08","ERROR_IN_ANALYZE_CITATION",[66,79],[813,819,822,825,831,834,837,840,843,849,853,856,859,862,865,871,877,880,883,886,889,892,895,898,901,909,912,915],{"id":814,"text":815,"url":816,"identifiers":817},"4c68646b-0035-4279-8000-0006b275d4fa","Detora M, Mccarthy RJ. Commentary ovariohysterectomy versus ovariectomy for elective sterilization of female dogs and cats: is removal of the uterus necessary? J Am Vet Med Assoc. 2011;11:1409–12.","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":818},"10.1007\u002Fs10440-022-00541-7",{"id":814,"text":820,"url":816,"identifiers":821},"Van Goethem B, Schaefers-Okkens A, Kirpensteijn J. Making a rational choice between ovariectomy and ovariohysterectomy in the dog: a discussion of the benefits of either technique. Vet Surg. 2006;35:136–43.",{"doi":818},{"id":814,"text":823,"url":816,"identifiers":824},"Coisman JG, Case JB, Shih A, Harrison K, Isaza N, Ellison G. Comparison of surgical variables in cats undergoing single-incision laparoscopic ovariectomy using a LigaSure or extracorporeal suture versus open ovariectomy. Vet Surg. 2014;43:38–44.",{"doi":818},{"id":826,"text":827,"url":828,"identifiers":829},"69b9b692-2c0b-4321-b1b6-95db069416ee","van Nimwegen SA, Kirpensteijn J. Laparoscopic ovariectomy in cats: comparison of laser and bipolar electrocoagulation. J Feline Med Surg. 2007;9:397–403.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1098612X07000642",{"doi":830},"10.1016\u002Fj.jfms.2007.03.007",{"id":814,"text":832,"url":816,"identifiers":833},"Shih AC, CASE JB, Coisman JG, Isaza NM, Junior DA, III Maisenbacher HW. Cardiopulmonary effects of laparoscopic Ovariectomy of variable duration in cats. Vet Surg. 2015;44:2–6.",{"doi":818},{"id":814,"text":835,"url":816,"identifiers":836},"Peeters ME, Kirpensteijn J. Comparison of surgical variables and short-term postoperative complications in healthy dogs undergoing ovariohysterectomy or ovariectomy. J Am Vet Med Assoc. 2011;238:189–94.",{"doi":818},{"id":814,"text":838,"url":816,"identifiers":839},"Okkens AC, Kooistra HS, Nickel RF. Comparison of long-term effects of ovariectomy versus ovariohysterectomy in bitches. J Reprod Fertil. 1997;51:227–31.",{"doi":818},{"id":814,"text":841,"url":816,"identifiers":842},"Tallant A, Ambros B, Freire C, Sakals S. Comparison of intraoperative and postoperative pain during canine ovariohysterectomy and ovariectomy. Can Vet J. 2016;57:741–6.",{"doi":818},{"id":844,"text":845,"url":846,"identifiers":847},"a01e1194-9e6d-4693-8577-ad1bb96755cd","Jensen MP, Chen C, Brugger AM. Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain. J Pain. 2003;4:407–14.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1526590003007168",{"doi":848},"10.1016\u002Fs1526-5900(03)00716-8",{"id":18,"text":850,"url":851,"identifiers":852},"Hellyer PW, Uhrig SR, Robinson NG. Feline Acute Pain Scale. Fort Collins: State University Veterinary Medical Center; 2006. http:\u002F\u002Fcsu-cvmbs.colostate.edu\u002FDocuments\u002Fanesthesia-pain-management-pain-score-feline.pdf>. Accessed 10 May 2015","http:\u002F\u002Fcsu-cvmbs.colostate.edu\u002FDocuments\u002Fanesthesia-pain-management-pain-score-feline.pdf>",{},{"id":814,"text":854,"url":816,"identifiers":855},"Reid J, Scott EM, Calvo G, Nolan AM. Definitive Glasgow acute pain scale for cats: validation and intervention level. Vet Rec. 2017;180:449.",{"doi":818},{"id":814,"text":857,"url":816,"identifiers":858},"Brondani JT, Luna SPL, Minto BW, Santos BPR, Beier SL, Matsubara LM, Padovani CR. Validade e responsividade de uma escala multidimensional para avaliação de dor pós-operatória em gatos. Arq Bras Med Vet Zootec. 2012;6:1529–38.",{"doi":818},{"id":814,"text":860,"url":816,"identifiers":861},"Valverde A, Cantwell S, Hernández J, Brotherson C. Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs. Vet Anaesth Analg. 2004;31:40–5.",{"doi":818},{"id":814,"text":863,"url":816,"identifiers":864},"Pypendop BH, Brosnan RJ, Siao KT, Stanley SD. Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane. Am J Vet Res. 2008;69:531–6.",{"doi":818},{"id":866,"text":867,"url":868,"identifiers":869},"d577511e-ff83-4e67-acad-236168db789e","Steagall PV, Taylor PM, Brondani JT, Luna SP, Dixon MJ. Antinociceptive effects of tramadol and acepromazine in cats. J Feline Med Surg. 2008;10:24–31.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1098612X07001313",{"doi":870},"10.1016\u002Fj.jfms.2007.06.009",{"id":872,"text":873,"url":874,"identifiers":875},"8126cd23-08aa-44c6-9ab4-8da17d2a4a76","Hellyer P, Rodan I, Brunt J, Downing R, Hagedorn JE, Robertson SA. AAHA\u002FAAFP pain management guidelines for dogs and cats. J Feline Med Surg. 2007;6:466–80.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1098612X07001519",{"doi":876},"10.1016\u002Fj.jfms.2007.09.001",{"id":814,"text":878,"url":816,"identifiers":879},"Brondani JT, Luna SP, Beier SL, et al. Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy. J Feline Med Surg. 2009;11:420–9.",{"doi":818},{"id":814,"text":881,"url":816,"identifiers":882},"Mollenhoff A, Nolte I, Kramer S. Anti-nociceptive efficacy of carprofen, levomethadone and buprenorphine for pain relief in cats following major orthopaedic surgery. J Vet Med A Physiol Pathol Clin Med. 2005;52:186–98.",{"doi":818},{"id":814,"text":884,"url":816,"identifiers":885},"Smith JD, Allen SW, Quandt JE, Tackett RL. Indicators of postoperative pain in cats and correlation with clinical criteria. Am J Vet Res. 1996;57:1674–8.",{"doi":818},{"id":814,"text":887,"url":816,"identifiers":888},"Cambridge AJ, Tobias KM, Newberry RC, et al. Subjective and objective measurements of postoperative pain in cats. J Am Vet Med Assoc. 2000;217:685–90.",{"doi":818},{"id":872,"text":890,"url":874,"identifiers":891},"Epstein M, Rodan I, Griffenhagen G, Kadrlik J, Petty M, Robertson S, Simpson W. 2015 AAHA\u002FAAFP pain management guidelines for dogs and cats. J Am Anim Hosp Assoc. 2015;2:67–84.",{"doi":876},{"id":814,"text":893,"url":816,"identifiers":894},"Murison P. Prevention and treatment of perioperative hypothermia in animals under 5 kg bodyweight. Pract. 2001;23:412–8.",{"doi":818},{"id":814,"text":896,"url":816,"identifiers":897},"Smith JD, Allen SW, Quandt JE. Changes in cortisol concentration in response to stress and postoperative pain in client-owned cats and correlation with objective clinical variables. Am J Vet Res. 1999;60:432–6.",{"doi":818},{"id":814,"text":899,"url":816,"identifiers":900},"Carroll GL, Howe LB, Peterson KD. Analgesic efficacy of preoperative administration of meloxicam or butorphanol in onychectomized cats. J Am Vet Med Assoc. 2005;226:913–9.",{"doi":818},{"id":18,"text":902,"url":903,"identifiers":904},"Steagall PV, Benito J, Monteiro BP, Doodnaught GM, Beauchamp G, Evangelista MC. Analgesic effects of gabapentin and buprenorphine in cats undergoing ovariohysterectomy using two pain-scoring systems: a randomized clinical trial. J Feline Med Surg. 2017. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1098612X17730173.","https:\u002F\u002Fdoi.org\u002F10.1177\u002F1098612x17730173",{"mag":905,"openalex":906,"pm":907,"doi":908},"2754464480","W2754464480","28920534","10.1177\u002F1098612x17730173",{"id":814,"text":910,"url":816,"identifiers":911},"Doodnaught GM, Benito J, Monteiro BP, Beauchamp G, Grasso SC, Steagall PV. Agreement among undergraduate and graduate veterinary students and veterinary anesthesiologists on pain assessment in cats and dogs: a preliminary study. Can Vet J. 2017;58:805–8.",{"doi":818},{"id":814,"text":913,"url":816,"identifiers":914},"Brondani JT, Luna S, Padovani CR. Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats. Am J Vet Res. 2011;2:174–83.",{"doi":818},{"id":814,"text":916,"url":816,"identifiers":917},"Höglund OV, Olsson K, Hagman R, Öhlund M, Olsson U, Lagerstedt AS. Comparison of haemodynamic changes during two surgical methods for neutering female dogs. Res Vet Sci. 2011;91:159–63.",{"doi":818},{"id":919,"createTime":920,"updateTime":921,"relativeEntities":922,"slug":923,"properties":924,"entityType":185,"verifyStatus":186,"verifyTime":935,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":936,"fullTextUrl":18,"authors":937,"publicationType":289,"publisherRelationship":1013,"citationCount":19,"citationInfo":1064,"publishDate":1067,"publishYear":1065,"citationAnalyzeStatus":810,"lastCitationAnalyze":1068,"indexDatabases":1069,"openAccess":18,"references":18,"isForceReanalyzing":595},"cd1df26d-f874-4578-810e-3677e03096e2","2024-01-13T00:09:40.413+00:00","2026-08-17T07:44:17.950+00:00",[],"The-potential-spread-of-highly-pathogenic-avian-influenza-virus-via-dynamic-contacts-between-poultry-premises-in-Great-Britain",{"abstract":925,"title":927,"gsPaper":929,"references":931,"doi":933},{"EN":926},"Highly pathogenic avian influenza (HPAI) viruses have had devastating effects on poultry industries worldwide, and there is concern about the potential for HPAI outbreaks in the poultry industry in Great Britain (GB). Critical to the potential for HPAI to spread between poultry premises are the connections made between farms by movements related to human activity. Movement records of catching teams and slaughterhouse vehicles were obtained from a large catching company, and these data were used in a simulation model of HPAI spread between farms serviced by the catching company, and surrounding (geographic) areas. The spread of HPAI through real-time movements was modelled, with the addition of spread via company personnel and local transmission. The model predicted that although large outbreaks are rare, they may occur, with long distances between infected premises. Final outbreak size was most sensitive to the probability of spread via slaughterhouse-linked movements whereas the probability of onward spread beyond an index premises was most sensitive to the frequency of company personnel movements. Results obtained from this study show that, whilst there is the possibility that HPAI virus will jump from one cluster of farms to another, movements made by catching teams connected fewer poultry premises in an outbreak situation than slaughterhouses and company personnel. The potential connection of a large number of infected farms, however, highlights the importance of retaining up-to-date data on poultry premises so that control measures can be effectively prioritised in an outbreak situation.",{"EN":928},"The potential spread of highly pathogenic avian influenza virus via dynamic contacts between poultry premises in Great Britain",{"VOID":930},"[\"4202513014055724068\"]",{"VOID":932},"Green DM, Kiss IZ, Kao RR: Modelling the initial spread of foot and mouth disease through livestock movements. Proc R Soc B. 2006, 273: 2729-35. 10.1098\u002Frspb.2006.3648.\nKao RR, Green DM, Johnson J, Kiss IZ: Disease dynamics over very different time-scales: foot-and-mouth disease and scrapie on the network of livestock movements in the UK. JR Soc Interface. 2007, 4: 907-916. 10.1098\u002Frsif.2007.1129.\nKiss I, Green D, Kao RR: The network of sheep movements within Great Britain: Network properties and their implications for infectious disease spread. JR Soc Interface. 2006, 3: 669-677. 10.1098\u002Frsif.2006.0129.\nRead JM, Keeling MJ: Disease evolution on networks: the role of contact structure. Proc R Soc Lond B. 2003, 270: 699-708. 10.1098\u002Frspb.2002.2305.\nDefra: Livestock identification and movements. 2011, consulted 06October 2011, [http:\u002F\u002Fwww.defra.gov.uk\u002Ffood-farm\u002Fanimals\u002Fmovements]\nGibbens N: Avian influenza outbreak in Oxfordshire. Vet Rec. 2008, 162 (24): 795.\nManvell RJ, Londt BZ, Ceeraz V, Cox WJ, Essen S, Banks J, Slomka MJ, Pavlidis T, Irvine RM, Wilesmith JW, Sharpe CE, Hurst A, Alexander DJ, Brown IH: Low pathogenic avian influenza in domestic fowl in Norfolk, England, March and April, 2006. Vet Rec. 2008, 162 (9): 278-80. 10.1136\u002Fvr.162.9.278.\nAlexander DJ: The epidemiology and control of avian influenza and Newcastle disease. Comp Pathol. 1995, 112 (2): 105-126. 10.1016\u002FS0021-9975(05)80054-4.\nBahl AK, Langston A, Van Deussen RA, Pomeroy BS, Newman J, Karunakaran D, Halvorson D: Prevention and control of avian influenza in turkeys. Proc Annu Meet US Anim Health Assoc. 1979, 83: 355-363.\nDent JE, Kao RR, Kiss IZ, Hyder K, Arnold M: Contact structures in the poultry industry in Great Britain: Exploring transmission routes for a potential avian influenza virus epidemic. BMC Veterinary Research. 2008, 4: 27-10.1186\u002F1746-6148-4-27. [http:\u002F\u002Fwww.biomedcentral.com\u002F1746-6148\u002F4\u002F27]\nDefra: Welfare of Animals During Transport. consulted 11 March 2010, [http:\u002F\u002Fwww.defra.gov.uk\u002Ffood-farm\u002Fanimals\u002Fwelfare\u002Ftransport\u002F]\nKeeling MJ, Eames KT: Networks and epidemic models. JR Soc Interface. 2005, 2 (4): 295-307. 10.1098\u002Frsif.2005.0051.\nGittins J, Canning P: Review of the Poultry Catching Industry in England and Wales. 2006, consulted on 06 October 2011, [http:\u002F\u002Fwww.food.gov.uk\u002Fmultimedia\u002Fpdfs\u002Fpoultycatchreview.pdf]\nPantin-Jackwood MJ, Kapczynski DR, Wasilenko JL, Sarmento L: Comparison of the pathogenicity of different H5N1 HPAI viruses in chickens and ducks. Proceedings of the American Association of Veterinary Laboratory Diagnosticians 50th Annual Conference. 2007, 125:\nSharkey KJ, Bowers RG, Morgan KJ, Robinson SE, Christley RM: Epidemiological consequences of an incursion of highly pathogenic avian influenza into the British poultry flock. Proc R Soc B. 2007, 275: 1630-[http:\u002F\u002Frspb.royalsocietypublishing.org\u002Fcontent\u002F275\u002F1630\u002F19.full]\nSavill NJ, Rose SG, Woolhouse MEJ: Detection of mortality clusters associated with highly pathogenic avian influenza in poultry: a theoretical analysis. JR Soc Interface. 2008, 5: 1049-1419.\nStegeman A, Bouma A, Elbers ARW, De Jong MCM, Nodelijk G, De Klerk F, Koch G, van Boven M: Avian influenza A virus (H7N7) epidemic in The Netherlands in 2003: Course of the epidemic and effectiveness of control measures. J Infect Dis. 2004, 190 (12): 20.\nYoon H, Park CK, Nam HM, Wee SH: Virus spread pattern within infected chicken farms using regression model: the 2003-2004 HPAI epidemic in the republic of Korea. Journal of Veterinary Medicine Series B. 2005, 52 (10): 428-431. 10.1111\u002Fj.1439-0450.2005.00891.x.\nDefra: Preliminary epidemiology report: avian influenza outbreak in Suffolk, November 2007 as at 26 November 2007. consulted 06 October 2011, [http:\u002F\u002Farchive.defra.gov.uk\u002Ffoodfarm\u002Ffarmanimal\u002Fdiseases\u002Fatoz\u002Fai\u002Fdocuments\u002Fai-prelim-epireport071129.pdf]\nGarske T, Clarke P, Ghani A: The transmissibility of highly pathogenic avian influenza in commercial poultry in industrialised countries. PloS ONE. 2007, 2 (4): e349-10.1371\u002Fjournal.pone.0000349.\nEvans SJ, Sayers AR: A longitudinal study of Campylobacter infection of broiler flocks in Great Britain. Preventive Veterinary Medicine. 2000, 46: 209-223. 10.1016\u002FS0167-5877(00)00143-4.\nTruscott J, Garske T, Chis-Ster I, Guitian J, Pfeiffer D, Snow L, Wilesmith J, Ferguson N, Ghani A: Control of a highly pathogenic H5N1 avian influenza outbreak in the GB poultry flock. Proceedings of the Royal Society B. 2000, 274 (1623): 2287.",{"VOID":934},"10.1186\u002F1746-6148-7-59","2024-06-24T16:47:54.875+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002F1746-6148-7-59",[938,962,979,996],{"id":939,"sortIndex":19,"researcher":18,"roles":940,"affiliations":941,"properties":959,"displayName":961,"givenName":18,"familyName":18},"068b1f88-303a-4a62-8aa6-cddce1280dfe",[617],[942,950],{"id":943,"sortIndex":19,"affiliation":944,"properties":18},"b0f7ea05-b070-4793-90eb-024a1e3ad2e9",{"id":943,"createTime":18,"updateTime":18,"relativeEntities":945,"slug":18,"properties":946,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":949,"statistic":18},[],{"title":947},{"VI":948},"Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK",[],{"id":951,"sortIndex":141,"affiliation":952,"properties":958},"abbac5f1-ef8e-4f46-a21e-639ceb54df24",{"id":951,"createTime":18,"updateTime":18,"relativeEntities":953,"slug":18,"properties":954,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":957,"statistic":18},[],{"title":955},{"VI":956},"Clinical Trials Research Unit, University of Leeds, Leeds, UK",[],{},{"title":960},{"VI":961},"Jennifer E Dent",{"id":963,"sortIndex":141,"researcher":18,"roles":964,"affiliations":965,"properties":974,"displayName":976,"givenName":18,"familyName":18},"86c02869-e419-415f-9a22-7e748724aa89",[617],[966],{"id":967,"sortIndex":19,"affiliation":968,"properties":18},"6512bbc5-94d0-442b-bea6-a7bc089e8944",{"id":967,"createTime":18,"updateTime":18,"relativeEntities":969,"slug":18,"properties":970,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":973,"statistic":18},[],{"title":971},{"VI":972},"Department of Mathematics, Mantell Building, University of Sussex, Falmer, UK",[],{"title":975,"gsAuthor":977},{"VI":976},"Istvan Z Kiss",{"VOID":978},"[\"Wf3AWDUAAAAJ\"]",{"id":980,"sortIndex":233,"researcher":18,"roles":981,"affiliations":982,"properties":991,"displayName":993,"givenName":18,"familyName":18},"833a381d-c533-46cc-9914-8d2fea60c661",[617],[983],{"id":984,"sortIndex":19,"affiliation":985,"properties":18},"52fed401-afc1-4c65-9310-61b94b0c9148",{"id":984,"createTime":18,"updateTime":18,"relativeEntities":986,"slug":18,"properties":987,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":990,"statistic":18},[],{"title":988},{"VI":989},"Faculty of Veterinary Medicine, Glasgow, UK",[],{"title":992,"gsAuthor":994},{"VI":993},"Rowland R Kao",{"VOID":995},"[\"ccDXRHMAAAAJ\"]",{"id":997,"sortIndex":253,"researcher":18,"roles":998,"affiliations":999,"properties":1008,"displayName":1010,"givenName":18,"familyName":18},"41d706e0-137a-4f2f-b2fa-313c87fbc0aa",[617],[1000],{"id":1001,"sortIndex":19,"affiliation":1002,"properties":18},"942bfef0-6a1d-40ba-89ab-9f0b90b72bbd",{"id":1001,"createTime":18,"updateTime":18,"relativeEntities":1003,"slug":18,"properties":1004,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1007,"statistic":18},[],{"title":1005},{"VI":1006},"Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, UK",[],{"title":1009,"gsAuthor":1011},{"VI":1010},"Mark Arnold",{"VOID":1012},"[\"noA-k58AAAAJ\"]",{"url":936,"publisher":1014,"properties":1059},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1015,"slug":10,"properties":1016,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1019,"manageAffiliations":1028,"indexDatabases":1039,"url":18,"thumbnailPath":18,"statistic":1054,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1017,"eissn":1018},{"EN":13},{"VOID":15},[1020,1024],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1021,"label":1022,"description":1023,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1025,"label":1026,"description":1027,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[1029,1034],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":1030,"slug":18,"properties":1031,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1033,"statistic":18},[],{"title":1032},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":1035,"slug":18,"properties":1036,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1038,"statistic":18},[],{"title":1037},{"EN":46},[],[1040,1047],{"id":50,"indexDatabase":1041,"url":61,"indexYears":62,"academicFieldIds":1046,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":1042,"label":1043,"description":1044,"key":58,"publicationTags":1045,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":1048,"url":81,"indexYears":18,"academicFieldIds":1053,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":1049,"label":1050,"description":1051,"key":77,"publicationTags":1052,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":1055,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":1056,"totalCitation":121,"totalCitationByYear":1057,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":1058,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"pages":1060,"volume":1062},{"VOID":1061},"1-14",{"VOID":1063},"7",{"total":19,"publishYear":1065,"statisticByYear":1066},2011,{},"2011-10-13","2026-08-17T07:44:17.949+00:00",[66,79],{"id":1071,"createTime":1072,"updateTime":1073,"relativeEntities":1074,"slug":1075,"properties":1076,"entityType":185,"verifyStatus":186,"verifyTime":1087,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1088,"fullTextUrl":18,"authors":1089,"publicationType":289,"publisherRelationship":1279,"citationCount":19,"citationInfo":1330,"publishDate":1333,"publishYear":1331,"citationAnalyzeStatus":810,"lastCitationAnalyze":1073,"indexDatabases":1334,"openAccess":18,"references":18,"isForceReanalyzing":595},"f56e2f4f-5398-41b0-8142-f1f1cb581087","2024-01-20T22:52:32.829+00:00","2026-08-17T04:20:43.677+00:00",[],"Safety-studies-and-viral-shedding-of-intramuscular-administration-of-oncolytic-vaccinia-virus-TG6002-in-healthy-beagle-dogs",{"abstract":1077,"title":1079,"gsPaper":1081,"references":1083,"doi":1085},{"EN":1078},"Cancer is a leading cause of mortality for both humans and dogs. As spontaneous canine cancers appear to be relevant models of human cancers, developing new therapeutic approaches could benefit both species. Oncolytic virotherapy is a promising therapeutic approach in cancer treatment. TG6002 is a recombinant oncolytic vaccinia virus deleted in the thymidine kinase and ribonucleotide reductase genes and armed with the suicide gene FCU1 that encodes a protein which catalyses the conversion of the non-toxic 5-fluorocytosine into the toxic metabolite 5-fluorouracil. Previous studies have shown the ability of TG6002 to infect and replicate in canine tumor cell lines, and demonstrated its oncolytic potency in cell lines, xenograft models and canine mammary adenocarcinoma explants. Moreover, 5-fluorouracil synthesis has been confirmed in fresh canine mammary adenocarcinoma explants infected with TG6002 with 5-fluorocytosine. This study aims at assessing the safety profile and viral shedding after unique or repeated intramuscular injections of TG6002 in seven healthy Beagle dogs. Repeated intramuscular administrations of TG6002 at the dose of 5 × 107 PFU\u002Fkg resulted in no clinical or biological adverse effects. Residual TG6002 in blood, saliva, urine and feces of treated dogs was not detected by infectious titer assay nor by qPCR, ensuring the safety of the virus in the dogs and their environment. These results establish the good tolerability of TG6002 in healthy dogs with undetectable viral shedding after multiple injections. This study supports the initiation of further studies in canine cancer patients to evaluate the oncolytic potential of TG6002 and provides critical data for clinical development of TG6002 as a human cancer therapy.",{"EN":1080},"Safety studies and viral shedding of intramuscular administration of oncolytic vaccinia virus TG6002 in healthy beagle dogs",{"VOID":1082},"[\"6288873452772549917\"]",{"VOID":1084},"Merlo DF, Rossi L, Pellegrino C, Ceppi M, Cardellino U, Capurro C, et al. Cancer incidence in pet dogs: findings of the animal tumor registry of Genoa, Italy. J Vet Intern Med. 2008;22:976–84.\nKelsey JL, Moore AS, Glickman T. Epidemiologic studies of risk factors for Cancer in pet dogs. Epidemiol Rev. 1998;20:204–17.\nMiest TS, Cattaneo R. New viruses for cancer therapy: meeting clinical needs. Nat Rev Microbiol. 2014;12:23–34.\nHarrington K, Freeman DJ, Kelly B, Harper J, Soria J-C. Optimizing oncolytic virotherapy in cancer treatment. Nat Rev Drug Discov. 2019;18:689–706.\nPatil SS, Gentschev I, Nolte I, Ogilvie G, Szalay AA. Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients. J Transl Med. 2012;10:3.\nSánchez D, Cesarman-Maus G, Amador-Molina A, Lizano M. Oncolytic viruses for canine Cancer treatment. Cancers. 2018;10.\nHaddad D. Genetically engineered Vaccinia viruses as agents for Cancer treatment, imaging, and transgene delivery. Front Oncol. 2017;7:96.\nKirn DH, Thorne SH. Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer. Nat Rev Cancer. 2009;9:64–71.\nShen Y, Nemunaitis J. Fighting cancer with vaccinia virus: teaching new tricks to an old dog. Mol Ther J Am Soc Gene Ther. 2005;11:180–95.\nBreitbach CJ, Burke J, Jonker D, Stephenson J, Haas AR, Chow LQM, et al. Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature. 2011;477:99–102.\nFoloppe J, Kempf J, Futin N, Kintz J, Cordier P, Pichon C, et al. The enhanced tumor specificity of TG6002, an armed Oncolytic Vaccinia virus deleted in two genes involved in nucleotide metabolism. Mol Ther Oncolytics. 2019;14:1–14.\nErbs P, Regulier E, Kintz J, Leroy P, Poitevin Y, Exinger F, et al. In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase\u002Furacil phosphoribosyltransferase fusion gene. Cancer Res. 2000;60:3813–22.\nBéguin J, Foloppe J, Laloy E, Nourtier V, Farine I, Gantzer M, et al. Abstract 1446: characterization, evaluation and safety studies of the oncolytic Vaccinia virus TG6002 for canine cancer therapy. Atlanta: Immunology. American Association for Cancer Research; 2019. p. 1446–6. https:\u002F\u002Fdoi.org\u002F10.1158\u002F1538-7445.AM2019-1446.\nRowell JL, McCarthy DO, Alvarez CE. Dog models of naturally occurring cancer. Trends Mol Med. 2011;17:380–8.\nRegan D, Garcia K, Thamm D. Clinical, pathological, and ethical considerations for the conduct of clinical trials in dogs with naturally occurring Cancer: a comparative approach to accelerate translational drug development. ILAR J. 2018;59:99–110.\nPaoloni M, Khanna C. Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer. 2008;8:147–56.\nBuller RM, Palumbo GJ. Poxvirus pathogenesis. Microbiol Rev. 1991;55:80–122.\nPark B-H, Hwang T, Liu T-C, Sze DY, Kim J-S, Kwon H-C, et al. Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial. Lancet Oncol. 2008;9:533–42.\nHeo J, Reid T, Ruo L, Breitbach CJ, Rose S, Bloomston M, et al. Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nat Med. 2013;19:329–36.\nDowns-Canner S, Guo ZS, Ravindranathan R, Breitbach CJ, O’Malley ME, Jones HL, et al. Phase 1 study of intravenous Oncolytic poxvirus (vvDD) in patients with advanced solid cancers. Mol Ther J Am Soc Gene Ther. 2016;24:1492–501.\nMell LK, Brumund KT, Daniels GA, Advani SJ, Zakeri K, Wright ME, et al. Phase I trial of intravenous Oncolytic Vaccinia virus (GL-ONC1) with Cisplatin and radiotherapy in patients with Locoregionally advanced head and neck carcinoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2017;23:5696–702.\nKung C-H, Kuo S-C, Chen T-L, Weng W-S. Isolation of vaccinia JX594 from pustules following therapy for hepatocellular carcinoma. BMC Cancer. 2015;15:704.\nBiondo A, Pedersen JV, Karapanagiotou EM, Tunariu N, Mansfield D, Sassi S, et al. 1258 POSTER phase I clinical trial of a genetically modified Oncolytic Vaccinia virus GL-ONC1 with green fluorescent protein imaging. Eur J Cancer. 2011;47:S162.\nAppel MJ, Paoletti E. Immune response to vaccinia virus and recombinant virus products in dogs. Am J Vet Res. 1988;49:1932–4.\nLederman E, Miramontes R, Openshaw J, Olson VA, Karem KL, Marcinak J, et al. Eczema vaccinatum resulting from the transmission of vaccinia virus from a smallpox vaccinee: an investigation of potential fomites in the home environment. Vaccine. 2009;27:375–7.\nAbrahão JS, de Souza Trindade G, JMS F, Campos RK, Bonjardim CA, PCP F, et al. Long-lasting stability of Vaccinia virus strains in murine feces: implications for virus circulation and environmental maintenance. Arch Virol. 2009;154:1551–3.\nEssbauer S, Meyer H, Porsch-Ozcürümez M, Pfeffer M. Long-lasting stability of vaccinia virus (orthopoxvirus) in food and environmental samples. Zoonoses Public Health. 2007;54:118–24.\nWestberg S, Sadeghi A, Svensson E, Segall T, Dimopoulou M, Korsgren O, et al. Treatment efficacy and immune stimulation by AdCD40L gene therapy of spontaneous canine malignant melanoma. J Immunother. 2013;36:350–8.\nvon Euler H, Sadeghi A, Carlsson B, Rivera P, Loskog A, Segall T, et al. Efficient adenovector CD40 ligand immunotherapy of canine malignant melanoma. J Immunother. 2008;31:377–84.\nSiddiqui F, Li C-Y, Larue SM, Poulson JM, Avery PR, Pruitt AF, et al. A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. Mol Cancer Ther. 2007;6:380–9.\nJourdier T-M, Moste C, Bonnet M-C, Delisle F, Tafani J-P, Devauchelle P, et al. Local immunotherapy of spontaneous feline fibrosarcomas using recombinant poxviruses expressing interleukin 2 (IL2). Gene Ther. 2003;10:2126–32.\nMacNeill AL, Weishaar KM, Séguin B, Powers BE. Safety of an Oncolytic Myxoma virus in dogs with soft tissue sarcoma. Viruses. 2018;10.\nHwang CC, Igase M, Sakurai M, Haraguchi T, Tani K, Itamoto K, et al. Oncolytic reovirus therapy: pilot study in dogs with spontaneously occurring tumours. Vet Comp Oncol. 2018;16:229–38.\nIlyinskaya GV, Mukhina EV, Soboleva AV, Matveeva OV, Chumakov PM. Oncolytic Sendai virus therapy of canine mast cell tumors (a pilot study). Front Vet Sci. 2018;5:116.\nNaik S, Galyon GD, Jenks NJ, Steele MB, Miller AC, Allstadt SD, et al. Comparative oncology evaluation of intravenous recombinant Oncolytic vesicular stomatitis virus therapy in spontaneous canine Cancer. Mol Cancer Ther. 2018;17:316–26.\nCejalvo T, Perisé-Barrios AJ, Del Portillo I, Laborda E, Rodriguez-Milla MA, Cubillo I, et al. Remission of spontaneous canine tumors after systemic cellular Viroimmunotherapy. Cancer Res. 2018;78:4891–901.\nAutio K, Knuuttila A, Kipar A, Pesonen S, Guse K, Parviainen S, et al. Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory beagles. Mol Ther Oncolytics. 2014;1:14002.\nAutio KPM, Ruotsalainen JJ, Anttila MO, Niittykoski M, Waris M, Hemminki A, et al. Attenuated Semliki Forest virus for cancer treatment in dogs: safety assessment in two laboratory beagles. BMC Vet Res. 2015;11:170.\nLeBlanc AK, Naik S, Galyon GD, Jenks N, Steele M, Peng K-W, et al. Safety studies on intravenous administration of oncolytic recombinant vesicular stomatitis virus in purpose-bred beagle dogs. Hum Gene Ther Clin Dev. 2013;24:174–81.\nSmith BF, Curiel DT, Ternovoi VV, Borovjagin AV, Baker HJ, Cox N, et al. Administration of a Conditionally Replicative Oncolytic Canine Adenovirus in Normal dogs. Cancer Biother Radiopharm. 2006;21:601–6.\nZeh HJ, Downs-Canner S, McCart JA, Guo ZS, Rao UNM, Ramalingam L, et al. First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity. Mol Ther J Am Soc Gene Ther. 2015;23:202–14.\nCripe TP, Ngo MC, Geller JI, Louis CU, Currier MA, Racadio JM, et al. Phase 1 study of intratumoral Pexa-Vec (JX-594), an oncolytic and immunotherapeutic vaccinia virus, in pediatric cancer patients. Mol Ther J Am Soc Gene Ther. 2015;23:602–8.\nCutler RE, Blair AD, Kelly MR. Flucytosine kinetics in subjects with normal and impaired renal function. Clin Pharmacol Ther. 1978;24:333–42.\nBlock ER, Bennett JE. Pharmacological studies with 5-fluorocytosine. Antimicrob Agents Chemother. 1972;1:476–82.\nBlock ER, Bennett JE, Livoti LG, Klein WJ, MacGregor RR, Henderson L. Flucytosine and amphotericin B: hemodialysis effects on the plasma concentration and clearance. Studies in man. Ann Intern Med. 1974;80:613–7.\nVermes A, Guchelaar HJ, Dankert J. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000;46:171–9.\nMalik R, Medeiros C, Wigney DI, Love DN. Suspected drug eruption in seven dogs during administration of flucytosine. Aust Vet J. 1996;74:285–8.\nPanciera DL, Bevier D. Management of cryptococcosis and toxic epidermal necrolysis in a dog. J Am Vet Med Assoc. 1987;191:1125–7.\nAshbee HR, Barnes RA, Johnson EM, Richardson MD, Gorton R, Hope WW. Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology. J Antimicrob Chemother. 2014;69:1162–76.\nHarris BE, Manning BW, Federle TW, Diasio RB. Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora. Antimicrob Agents Chemother. 1986;29:44–8.\nVermes A, Kuijper EJ, Guchelaar H-J, Dankert J. An in vitro study on the active conversion of flucytosine to fluorouracil by microorganisms in the human intestinal microflora. Chemotherapy. 2003;49:17–23.\nHwang T-H, Moon A, Burke J, Ribas A, Stephenson J, Breitbach CJ, et al. A mechanistic proof-of-concept clinical trial with JX-594, a targeted multi-mechanistic oncolytic poxvirus, in patients with metastatic melanoma. Mol Ther J Am Soc Gene Ther. 2011;19:1913–22.\nVail DM, Macewen EG. Spontaneously occurring tumors of companion animals as models for human Cancer. Cancer Investig. 2000;18:781–92.\nUva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, Castle J, et al. Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics. 2009;10:135.\nKnapp DW, Glickman NW, Denicola DB, Bonney PL, Lin TL, Glickman LT. Naturally-occurring canine transitional cell carcinoma of the urinary bladder a relevant model of human invasive bladder cancer. Urol Oncol. 2000;5:47–59.\nKnapp DW, Waters DJ. Naturally occurring cancer in pet dogs: important models for developing improved cancer therapy for humans. Mol Med Today. 1997;3:8–11.\nVeterinary cooperative oncology group. Common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1. Vet Comp Oncol. 2016;14:417–46.\nClinical Trials.gov [Internet]. National Library of Medicine (US). Identifier NCT03724071, Study of TG6002 (VV TK-RR-FCU1) in combination with 5-FC in patients with advanced gastrointestinal tumors; 2018 Oct 30. Available from: https:\u002F\u002Fclinicaltrials.gov\u002Fct2\u002Fshow\u002FNCT03724071.",{"VOID":1086},"10.1186\u002Fs12917-020-02524-y","2024-06-26T19:20:48.749+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-020-02524-y",[1090,1123,1136,1149,1162,1175,1188,1210,1225,1238,1251,1265],{"id":1091,"sortIndex":19,"researcher":18,"roles":1092,"affiliations":1093,"properties":1118,"displayName":1120,"givenName":18,"familyName":18},"bfdec821-8ae1-469a-acf9-c2e6badeb9fc",[617],[1094,1102,1110],{"id":1095,"sortIndex":19,"affiliation":1096,"properties":18},"8ed36cd1-8efa-4ea0-ac64-cf014f6df7c1",{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1097,"slug":18,"properties":1098,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1101,"statistic":18},[],{"title":1099},{"VI":1100},"Transgene, Illkirch-Graffenstaden, France",[],{"id":1103,"sortIndex":141,"affiliation":1104,"properties":18},"3f38f1a7-0a9f-4f2b-a348-25685332a171",{"id":1103,"createTime":18,"updateTime":18,"relativeEntities":1105,"slug":18,"properties":1106,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1109,"statistic":18},[],{"title":1107},{"VI":1108},"UMR Virologie, INRAE, Ecole Nationale Vétérinaire d’Alfort, ANSES, Université Paris-Est, Maisons-Alfort, France",[],{"id":1111,"sortIndex":233,"affiliation":1112,"properties":18},"04e4ce83-a29b-4d98-9311-0270500fea79",{"id":1111,"createTime":18,"updateTime":18,"relativeEntities":1113,"slug":18,"properties":1114,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1117,"statistic":18},[],{"title":1115},{"VI":1116},"Department of Internal Medicine, Ecole Nationale Vétérinaire d’Alfort, Université Paris-Est, Maisons-Alfort, France",[],{"title":1119,"gsAuthor":1121},{"VI":1120},"Jérémy Béguin",{"VOID":1122},"[\"iDsMiwgAAAAJ\"]",{"id":1124,"sortIndex":141,"researcher":18,"roles":1125,"affiliations":1126,"properties":1133,"displayName":1135,"givenName":18,"familyName":18},"2c296484-13ec-47c4-8313-6045c14e009d",[617],[1127],{"id":1095,"sortIndex":19,"affiliation":1128,"properties":18},{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1129,"slug":18,"properties":1130,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1132,"statistic":18},[],{"title":1131},{"VI":1100},[],{"title":1134},{"VI":1135},"Virginie Nourtier",{"id":1137,"sortIndex":233,"researcher":18,"roles":1138,"affiliations":1139,"properties":1146,"displayName":1148,"givenName":18,"familyName":18},"1e020318-b07c-45d4-87c4-c92d4269b67a",[617],[1140],{"id":1095,"sortIndex":19,"affiliation":1141,"properties":18},{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1142,"slug":18,"properties":1143,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1145,"statistic":18},[],{"title":1144},{"VI":1100},[],{"title":1147},{"VI":1148},"Murielle Gantzer",{"id":1150,"sortIndex":253,"researcher":18,"roles":1151,"affiliations":1152,"properties":1159,"displayName":1161,"givenName":18,"familyName":18},"5d50b670-984c-4c6b-8def-4e8040ca53aa",[617],[1153],{"id":1095,"sortIndex":19,"affiliation":1154,"properties":18},{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1155,"slug":18,"properties":1156,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1158,"statistic":18},[],{"title":1157},{"VI":1100},[],{"title":1160},{"VI":1161},"Sandrine Cochin",{"id":1163,"sortIndex":273,"researcher":18,"roles":1164,"affiliations":1165,"properties":1172,"displayName":1174,"givenName":18,"familyName":18},"db9c20f7-feba-4246-b512-3559132efd62",[617],[1166],{"id":1095,"sortIndex":19,"affiliation":1167,"properties":18},{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1168,"slug":18,"properties":1169,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1171,"statistic":18},[],{"title":1170},{"VI":1100},[],{"title":1173},{"VI":1174},"Johann Foloppe",{"id":1176,"sortIndex":688,"researcher":18,"roles":1177,"affiliations":1178,"properties":1185,"displayName":1187,"givenName":18,"familyName":18},"eec96ff4-b20e-4273-804a-221ce728a1e9",[617],[1179],{"id":1095,"sortIndex":19,"affiliation":1180,"properties":18},{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1181,"slug":18,"properties":1182,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1184,"statistic":18},[],{"title":1183},{"VI":1100},[],{"title":1186},{"VI":1187},"Jean-Marc Balloul",{"id":1189,"sortIndex":702,"researcher":18,"roles":1190,"affiliations":1191,"properties":1207,"displayName":1209,"givenName":18,"familyName":18},"b5ccbd86-34ff-4c68-8ce9-51af9a41f2a7",[617],[1192,1198],{"id":1103,"sortIndex":19,"affiliation":1193,"properties":18},{"id":1103,"createTime":18,"updateTime":18,"relativeEntities":1194,"slug":18,"properties":1195,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1197,"statistic":18},[],{"title":1196},{"VI":1108},[],{"id":1199,"sortIndex":141,"affiliation":1200,"properties":1206},"e985dfa1-7789-484f-a185-a7dd9df2c634",{"id":1199,"createTime":18,"updateTime":18,"relativeEntities":1201,"slug":18,"properties":1202,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1205,"statistic":18},[],{"title":1203},{"VI":1204},"Anatomical Pathology Unit, Biopôle, Ecole Nationale Vétérinaire d’Alfort, Université Paris-Est, Maisons-Alfort, France",[],{},{"title":1208},{"VI":1209},"Eve Laloy",{"id":1211,"sortIndex":101,"researcher":18,"roles":1212,"affiliations":1213,"properties":1222,"displayName":1224,"givenName":18,"familyName":18},"e53c9eea-85e7-4259-889b-cc03babb5c9c",[617],[1214],{"id":1215,"sortIndex":19,"affiliation":1216,"properties":18},"5eb19cea-c4ca-4a6b-9493-a75314b77516",{"id":1215,"createTime":18,"updateTime":18,"relativeEntities":1217,"slug":18,"properties":1218,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1221,"statistic":18},[],{"title":1219},{"VI":1220},"Oncovet Clinical Research, Loos, France",[],{"title":1223},{"VI":1224},"Dominique Tierny",{"id":1226,"sortIndex":729,"researcher":18,"roles":1227,"affiliations":1228,"properties":1235,"displayName":1237,"givenName":18,"familyName":18},"68d62fa8-83ae-47a8-ba1a-65929033a188",[617],[1229],{"id":1103,"sortIndex":19,"affiliation":1230,"properties":18},{"id":1103,"createTime":18,"updateTime":18,"relativeEntities":1231,"slug":18,"properties":1232,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1234,"statistic":18},[],{"title":1233},{"VI":1108},[],{"title":1236},{"VI":1237},"Bernard Klonjkowski",{"id":1239,"sortIndex":743,"researcher":18,"roles":1240,"affiliations":1241,"properties":1248,"displayName":1250,"givenName":18,"familyName":18},"62f5f0e7-e264-4542-8231-2456edf5e777",[617],[1242],{"id":1095,"sortIndex":19,"affiliation":1243,"properties":18},{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1244,"slug":18,"properties":1245,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1247,"statistic":18},[],{"title":1246},{"VI":1100},[],{"title":1249},{"VI":1250},"Eric Quemeneur",{"id":1252,"sortIndex":1253,"researcher":18,"roles":1254,"affiliations":1255,"properties":1262,"displayName":1264,"givenName":18,"familyName":18},"64bf9cc0-27a1-4203-b2b1-ad4945ea1f21",10,[617],[1256],{"id":1111,"sortIndex":19,"affiliation":1257,"properties":18},{"id":1111,"createTime":18,"updateTime":18,"relativeEntities":1258,"slug":18,"properties":1259,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1261,"statistic":18},[],{"title":1260},{"VI":1116},[],{"title":1263},{"VI":1264},"Christelle Maurey",{"id":1266,"sortIndex":1267,"researcher":18,"roles":1268,"affiliations":1269,"properties":1276,"displayName":1278,"givenName":18,"familyName":18},"2d59933d-abb8-439f-8f81-20bf865dc1b9",11,[617],[1270],{"id":1095,"sortIndex":19,"affiliation":1271,"properties":18},{"id":1095,"createTime":18,"updateTime":18,"relativeEntities":1272,"slug":18,"properties":1273,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1275,"statistic":18},[],{"title":1274},{"VI":1100},[],{"title":1277},{"VI":1278},"Philippe Erbs",{"url":1088,"publisher":1280,"properties":1325},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1281,"slug":10,"properties":1282,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1285,"manageAffiliations":1294,"indexDatabases":1305,"url":18,"thumbnailPath":18,"statistic":1320,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1283,"eissn":1284},{"EN":13},{"VOID":15},[1286,1290],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1287,"label":1288,"description":1289,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1291,"label":1292,"description":1293,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[1295,1300],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":1296,"slug":18,"properties":1297,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1299,"statistic":18},[],{"title":1298},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":1301,"slug":18,"properties":1302,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1304,"statistic":18},[],{"title":1303},{"EN":46},[],[1306,1313],{"id":50,"indexDatabase":1307,"url":61,"indexYears":62,"academicFieldIds":1312,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":1308,"label":1309,"description":1310,"key":58,"publicationTags":1311,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":1314,"url":81,"indexYears":18,"academicFieldIds":1319,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":1315,"label":1316,"description":1317,"key":77,"publicationTags":1318,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":1321,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":1322,"totalCitation":121,"totalCitationByYear":1323,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":1324,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"pages":1326,"volume":1328},{"VOID":1327},"1-13",{"VOID":1329},"16",{"total":19,"publishYear":1331,"statisticByYear":1332},2020,{},"2020-08-25",[66,79],{"id":1336,"createTime":1337,"updateTime":1338,"relativeEntities":1339,"slug":1340,"properties":1341,"entityType":185,"verifyStatus":186,"verifyTime":1352,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1353,"fullTextUrl":18,"authors":1354,"publicationType":289,"publisherRelationship":1413,"citationCount":1463,"citationInfo":1464,"publishDate":1466,"publishYear":1331,"citationAnalyzeStatus":810,"lastCitationAnalyze":1467,"indexDatabases":1468,"openAccess":18,"references":18,"isForceReanalyzing":595},"6ab18c89-495d-4f12-80ea-af2bc0fe06a2","2024-01-18T10:21:31.298+00:00","2026-08-14T10:02:18.835+00:00",[],"Spatial-and-temporal-distribution-of-foot-and-mouth-disease-outbreaks-in-Amhara-region-of-Ethiopia-in-the-period-1999-to-2016",{"abstract":1342,"title":1344,"gsPaper":1346,"references":1348,"doi":1350},{"EN":1343},"Foot and mouth disease (FMD) is an economically important trans-boundary viral disease of cloven-hoofed animals. It is caused by FMD virus, which belongs to the genus Aphthovirus and family Picornaviridae. FMD is a well-established endemic disease in Ethiopia since it was first detected in 1957. This retrospective study was carried out to identify the spatial and temporal distribution of FMD outbreaks in Amhara region of Ethiopia using 18 years (January 1999–December 2016) reported outbreak data. A total of 636 FMD outbreaks were reported in Amhara region of Ethiopia between 1999 and 2016 with an average and median of 35 and 13 outbreaks per year respectively. In this period, FMD was reported at least once in 58.5% of the districts (n = 79) and in all administrative zones of the region (n = 10). The average district level incidence of FMD outbreaks was 4.68 per 18 years (0.26 per district year). It recurs in a district as epidemic, on average in 5.86 years period. The incidence differed between administrative zones, being the lowest in East Gojjam and highest in North Shewa. The occurrence of FMD outbreaks was found to be seasonal with peak outbreaks in March and a low in August. The long-term trend of FMD outbreaks indicates a slight, but statistically significant (p \u003C 0.001) decrease over the study period. FMD occurred in all zones of the region and showed statistically significant decrease in the long-term trend. Numbers of outbreaks were relatively higher during dry season. The spatial and temporal distribution identified in this study should be considered in controlling the disease. As unregulated and frequent animal movements are the likely causes of high outbreak occurrence during the dry season, animal movement regulations should be considered for the long-term control of FMD.",{"EN":1345},"Spatial and temporal distribution of foot and mouth disease outbreaks in Amhara region of Ethiopia in the period 1999 to 2016",{"VOID":1347},"[\"9043969074050983035\"]",{"VOID":1349},"Mahy W B J. Foot and mouth disease virus. Springer-Verlag, Germany: Heidelberg; 2005. p.3.\nKnight-Jones TJD, Robinson L, Charleston B, Rodriguez LL, Gay CG, Sumption KJ, Vosloo W. Global foot and mouth disease researches update and gap analysis: an overview of global status and research needs. Transbound Emerg Dis. 2016;63(1):3–13.\nOIE. Manual of standards for diagnostic tests and vaccine. 2012,Volume I, part 2.\nBrito BP, Rodriguez LL, Hammond JM, Pinto J, Perez AM. Review of the global distribution of foot and mouth disease virus from 2007 to 2014. Transbound Emerg Dis. 2016;4(2).\nRweyemamu M, Roeder P, Mackay D, Sumption K, Brown-lie J, Leforban Y, Valarcher JF, Knowles NJ, Saraiva V. Epidemiological patterns of foot and mouth disease worldwide. Transbound Emerg Dis . 2008; 55:57.\nJemberu WT, Mourits MCM, Sahle M, Siraw B, Vernooij JCM, Hogeveen H. Epidemiology of foot and mouth disease in Ethiopia: a retrospective analysis of district level outbreaks (2007–2012). Transbound Emerg Dis. 2016;63:e246–59.\nRoeder PL, Knowles NJ. Foot and mouth disease virus type C situation: the first target for eradication. Glob Control FMD. 2008:14–7.\nRufael T, Catley A, Bogale A, Sahle M, Shiferaw Y. Foot and mouth disease in the Borana pastoral system, southern Ethiopia and implications for livelihoods and international trade. Trop Anim Health Prod. 2008;40:29–38.\nGulima D. Disease reporting, presentation: In VACNADA project close out workshop. 5th to 7th December, 2011, Debrezeit, Ethiopia, 2011.\nAyelet G, Gelaye E, Negussie H, Asmare K. Study on the epidemiology of foot and mouth disease in Ethiopia. Rev Sci Tech. 2012;31:789–98.\nMekonen H, Beyene D, Rufael T, Feyisa A, Fufa A. Study on the prevalence of foot and mouth disease in Borana and Guji zones. S Ethiop Vet World. 2011;4(7):293–6.\nTesfaye A, Sahle M, Abebe A, Muluneh A, Gizaw D. Sero-prevalence of foot and mouth disease in cattle in Borena zone, Oromia regional state, Ethiopia. Ethiop Vet J. 2016;20(1):55–66.\nWagari A. Sero-prevalence of foot and mouth disease in bulls of Borana origin quarantined in Adama. J Bio Biophy Mol Bio. 2016;1(1):1–10.\nSahle M. An epidemiological study on the genetic relationships of foot and mouth disease viruses in east Africa. South Africa: PhD thesis, Faculty of Veterinary Science, University of Pretoria; 2004.\nBeyene B, Tolosa T, Rufael T, Hailu B, Teklue T. Foot and mouth disease in selected districts of western Ethiopia: sero-prevalences and associated risk factors. Rev Sci Tech. 2015;34(3):939–52.\nGelaye E, Ayelet G, Abera T, Asmare K. Sero prevalence of foot and mouth disease in Bench Maji zone, south western Ethiopia. J Vet Med Anim Health, 2009, 1(1): 00 5–0010.\nMOARD (Ministry of Agriculture and Rural Development). Foot and mouth disease control plan. Addis Ababa: MOARD; 2006.\nPaton DJ, Sumption KJ, Charleston B. Options for control of foot and mouth disease: knowledge, capability and policy. BioSci. 2009;364:2657–67.\nRweyemamu M, Roeder P, Mackay D, Sumption K, Brown-lie J, Leforban Y, Valarcher JF, Knowles NJ, Saraiva V. Planning for the progressive control of foot-and-mouth disease worldwide. Transbound Emerg Dis. 2008b;55:73–87.\nAsfaw W, Sintaro T. The status of FMD in Ethiopia: a growing concern. Ethiop Vet Epi News Lett. 2000;1:1–5.\nBelayneh N, Molla W, Mesfine M, Jemberu WT. Modeling the transmission dynamics of foot and mouth disease in Amhara region. Ethiopia Prev Vet Med. 2019; https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.prevetmed.2019.04.002.\nPeralta EA, Carpenter TE, Farver TB. The application of time series analysis to determine the pattern of foot and mouth disease in cattle in Paraguay. Prev Vet Med. 1982;1:27–36.\nGallego ML, Perez AM, Thurmond MC. Temporal and spatial distributions of foot and mouth disease under three different strategies of control and eradication in Colombia (1982–2003). Vet Vet Res Com. 2007;31:819–34.\nRosenberg FJ, Astudillo V. Evaluation of alternative strategies for foot and mouth disease control in Paraguay In: New techniques in Veterinary Epidemiology and Economics. In Proceedings of an International Symposium: July 1976 at reading, England;1976:181–194.\nSharma SK, Singh GR. Cyclic behavior of foot and mouth disease in India. Vet Res Com. 1993;133:448–50.\nNejash A. Sero-prevalence, risk factors and distribution of foot and mouth disease in Ethiopia. Acta Trop. 2017;169:125–32.\nGunasekera UC, Sivasothy NA, Wedasingha S, Thayaparan B, Rotewewa M, Muralithas M, Baumann PO, Veerasak P. Analyzing the foot and mouth disease outbreak from 2008 to 2014 in cattle and buffaloes in Sri Lanka. Prev Vet Med. 2017;148:78–88.\nANRS (Amhara National Regional State Bureau of finance and economic development). Geography and Climate. Bahirdar, Amhara, Ethiopia; 2011.\nCSA. Central statistical agency (CSA) report, Federal Democratic Republic of Ethiopia, Addis Ababa; 2007.\nCSA. Agricultural sample survey, 2016\u002F17 (2008 E.C.), volume II: report on livestock and livestock characteristics (private peasant holdings). Statistical bulletin 573. Central statistical agency (CSA), Federal Democratic Republic of Ethiopia, Addis Ababa; 2017.\nThrusfield M. Veterinary epidemiology. 3rd ed. Oxford: Blackwell Sci; 2005. p. 149–231.\nCorder GW, Foreman DI. Non parametric statistics: a step-by-step approach. 2nd ed. New Jersey: Wiley; 2014. p. 210.",{"VOID":1351},"10.1186\u002Fs12917-020-02411-6","2024-05-16T08:37:47.408+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-020-02411-6",[1355,1370,1385,1400],{"id":1356,"sortIndex":19,"researcher":18,"roles":1357,"affiliations":1358,"properties":1367,"displayName":1369,"givenName":18,"familyName":18},"a2eae53b-5105-4e0a-850b-ec7768fcf6f1",[617],[1359],{"id":1360,"sortIndex":19,"affiliation":1361,"properties":18},"7a20253b-7a62-4874-b65c-f72eab73a18e",{"id":1360,"createTime":18,"updateTime":18,"relativeEntities":1362,"slug":18,"properties":1363,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1366,"statistic":18},[],{"title":1364},{"VI":1365},"College of Agriculture and Environmental Science, Bahir Dar University, Bahir Dar, Ethiopia",[],{"title":1368},{"VI":1369},"Endris Aman",{"id":1371,"sortIndex":141,"researcher":18,"roles":1372,"affiliations":1373,"properties":1382,"displayName":1384,"givenName":18,"familyName":18},"6f3dcd78-aea3-4e41-b1bf-bf9c9f017d69",[617],[1374],{"id":1375,"sortIndex":19,"affiliation":1376,"properties":18},"7664f76e-1723-4aff-ae41-0b3fcbf0044f",{"id":1375,"createTime":18,"updateTime":18,"relativeEntities":1377,"slug":18,"properties":1378,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1381,"statistic":18},[],{"title":1379},{"VI":1380},"College of Veterinary Medicine and Animal sciences, University of Gondar, Gondar, Ethiopia",[],{"title":1383},{"VI":1384},"Wassie Molla",{"id":1386,"sortIndex":233,"researcher":18,"roles":1387,"affiliations":1388,"properties":1397,"displayName":1399,"givenName":18,"familyName":18},"3776268c-957d-46a1-99a4-13aded95be82",[617],[1389],{"id":1390,"sortIndex":19,"affiliation":1391,"properties":18},"3654083b-bf3b-4ba6-bdda-b4c152929522",{"id":1390,"createTime":18,"updateTime":18,"relativeEntities":1392,"slug":18,"properties":1393,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1396,"statistic":18},[],{"title":1394},{"VI":1395},"Livestock Development Agency, Amhara National Regional State, Bahir Dar, Ethiopia",[],{"title":1398},{"VI":1399},"Zeleke Gebreegizabher",{"id":1401,"sortIndex":253,"researcher":18,"roles":1402,"affiliations":1403,"properties":1410,"displayName":1412,"givenName":18,"familyName":18},"e5300376-cb5c-485b-be4e-e8e2cf7ea874",[617],[1404],{"id":1375,"sortIndex":19,"affiliation":1405,"properties":18},{"id":1375,"createTime":18,"updateTime":18,"relativeEntities":1406,"slug":18,"properties":1407,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1409,"statistic":18},[],{"title":1408},{"VI":1380},[],{"title":1411},{"VI":1412},"Wudu Temesgen Jemberu",{"url":1353,"publisher":1414,"properties":1459},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1415,"slug":10,"properties":1416,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1419,"manageAffiliations":1428,"indexDatabases":1439,"url":18,"thumbnailPath":18,"statistic":1454,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1417,"eissn":1418},{"EN":13},{"VOID":15},[1420,1424],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1421,"label":1422,"description":1423,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1425,"label":1426,"description":1427,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[1429,1434],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":1430,"slug":18,"properties":1431,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1433,"statistic":18},[],{"title":1432},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":1435,"slug":18,"properties":1436,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1438,"statistic":18},[],{"title":1437},{"EN":46},[],[1440,1447],{"id":50,"indexDatabase":1441,"url":61,"indexYears":62,"academicFieldIds":1446,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":1442,"label":1443,"description":1444,"key":58,"publicationTags":1445,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":1448,"url":81,"indexYears":18,"academicFieldIds":1453,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":1449,"label":1450,"description":1451,"key":77,"publicationTags":1452,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":1455,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":1456,"totalCitation":121,"totalCitationByYear":1457,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":1458,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"pages":1460,"volume":1462},{"VOID":1461},"1-8",{"VOID":1329},35,{"total":1463,"publishYear":1331,"statisticByYear":1465},{"2021":233,"2022":729,"2023":1253,"2024":101,"2025":688,"2026":253},"2020-06-09","2026-08-14T10:02:18.834+00:00",[66,79],{"id":1470,"createTime":1471,"updateTime":1472,"relativeEntities":1473,"slug":1474,"properties":1475,"entityType":185,"verifyStatus":186,"verifyTime":1486,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1487,"fullTextUrl":18,"authors":1488,"publicationType":289,"publisherRelationship":1601,"citationCount":1651,"citationInfo":1652,"publishDate":1655,"publishYear":1653,"citationAnalyzeStatus":810,"lastCitationAnalyze":1656,"indexDatabases":1657,"openAccess":18,"references":18,"isForceReanalyzing":595},"587fa0e9-0c6d-45af-8141-14a12faf3cb9","2024-02-17T22:34:29.195+00:00","2026-07-28T08:16:07.196+00:00",[],"Molecular-identification-of-Pentatrichomonas-hominis-in-animals-in-central-and-western-Thailand",{"abstract":1476,"title":1478,"gsPaper":1480,"references":1482,"doi":1484},{"EN":1477},"Pentatrichomonas hominis inhabits the digestive tracts of several vertebrates, such as humans, monkeys, pigs, dogs, cats and rats. This protozoan was originally considered a commensal of the digestive tract but has subsequently been identified as a potential zoonotic parasite and a causative agent of diarrhoea. Molecular techniques are considered more sensitive and specific to detect P. hominis. This study aimed to determine the presence and genetic diversity of P. hominis in animals in Thailand. A total of 403 faecal samples were collected from 119 cats, 55 dogs, 73 goats, 35 monkeys, 55 cattle and 66 pigs, and the presence of P. hominis was determined using the nested polymerase chain reaction method. Sequence analysis of small-subunit ribosomal RNA genes was used to determine the genotype of the organism. Twenty-six samples (26\u002F403, 6.45%) were positive for P. hominis. The highest prevalence was found in cats (21\u002F119; 17.65%), followed by cattle (3\u002F55; 5.45%) and dogs (2\u002F55; 3.64%). Seven out of 26 nucleotides demonstrated 100% sequence identity with existing sequences; additionally, 16 novel sequence patterns were identified. All nucleotide sequences of P. hominis-positive samples were shown in the same branch with the previously described P. hominis sequences found in humans, dogs and goat. This is the first study on P. hominis infections in animals in Thailand. Our findings revealed that the prevalence of P. hominis was significantly higher in cats than in cattle and dogs. Cats were the main reservoir host; however, P. hominis can infect several kinds of animals. Therefore, the proper waste management of animals is necessary to reduce and prevent infection in the community.",{"EN":1479},"Molecular identification of Pentatrichomonas hominis in animals in central and western Thailand",{"VOID":1481},"[\"6515964096213728826\"]",{"VOID":1483},"Zhang N, Zhang H, Yu Y, Gong P, Li J, Li Z, et al. High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients. Parasit Vectors. 2019;12(1):423. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13071-019-3684-4.\nLi WC, Gong PT, Ying M, Li JH, Yang J, Li H, et al. Pentatrichomonas hominis: first isolation from the feces of a dog with diarrhea in China. Parasitol Res. 2014;113(5):1795–801. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00436-014-3825-9.\nLi X, Li J, Zhang X, Yang Z, Yang J, Gong P. Prevalence of Pentatrichomonas hominis infections in six farmed wildlife species in Jilin, China. Vet Parasitol. 2017;244:160–3. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2017.07.032.\nTolbert MK, Leutenegger CM, Lobetti R, Birrell J, Gookin JL. Species identification of trichomonads and associated coinfections in dogs with diarrhea and suspected trichomonosis. Vet Parasitol. 2012;187(1-2):319–22. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2011.12.031.\nLi W-C, J-m H. Fang Z, Ren Q, tang L, Kan Z-z, et al. prevalence of Tetratrichomonas buttreyi and Pentatrichomonas hominis in yellow cattle, dairy cattle, and water buffalo in China. Parasitol Res. 2020;119(2):637–47. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00436-019-06550-0.\nDogan N, Tuzemen NU. Three Pentatrichomonas hominis cases presenting with gastrointestinal symptoms. Turkiye Parazitol Derg. 2018;42(2):168–70. https:\u002F\u002Fdoi.org\u002F10.5152\u002Ftpd.2018.4846.\nMeloni D, Mantini C, Goustille J, Desoubeaux G, Maakaroun-Vermesse Z, Chandenier J, et al. Molecular identification of Pentatrichomonas hominis in two patients with gastrointestinal symptoms. J Clin Pathol. 2011;64(10):933–5. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fjcp.2011.089326.\nLi WC, Ying M, Gong PT, Li JH, Yang J, Li H, et al. Pentatrichomonas hominis: prevalence and molecular characterization in humans, dogs, and monkeys in northern China. Parasitol Res. 2016;115(2):569–74. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00436-015-4773-8.\nLi WC, Wang K, Gu Y. Occurrence of Blastocystis sp and Pentatrichomonas hominis in sheep and goats in China. Parasit Vectors. 2018;11:93.\nMaritz JM, Land KM, Carlton JM, Hirt RP. What is the importance of zoonotic trichomonads for human health? Trends Parasitol. 2014;30(7):333–41. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.pt.2014.05.005.\nBastos BF, Brener B, de Figueiredo MA, Leles D, Mendes-de-Almeida F. Pentatrichomonas hominis infection in two domestic cats with chronic diarrhea. JFMS Open Rep. 2018;4:2055116918774959.\nGookin JL, Stauffer SH, Levy MG. Identification of Pentatrichomonas hominis in feline fecal samples by polymerase chain reaction assay. Vet Parasitol. 2007;145(1-2):11–5. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2006.10.020.\nCrucitti T, Abdellati S, Ross DA, Changalucha J, Dyck E, Buve A. Detection of Pentatrichomonas hominis DNA in biological specimens by PCR. Lett Appl Microbiol. 2004;38(6):510–6. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1472-765X.2004.01528.x.\nDimasuay KG, Rivera WL. Molecular characterization of trichomonads isolated from animal hosts in the Philippines. Vet Parasitol. 2013;196(3-4):289–95. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2013.03.019.\nDufernez F, Walker RL, Noel C, Caby S, Mantini C, Delgado-Viscogliosi P, et al. Morphological and molecular identification of non-Tritrichomonas foetus trichomonad protozoa from the bovine preputial cavity. J Eukaryot Microbiol. 2007;54(2):161–8. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1550-7408.2007.00247.x.\nLi W, Li W, Gong P, Zhang C, Yang J, Zhang X, et al. The prevalence of intestinal trichomonads in Chinese pigs. Vet Parasitol. 2015;211(1-2):12–5. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2015.04.028.\nMostegl MM, Wetscher A, Richter B, Nedorost N, Dinhopl N, Weissenbock H. Detection of Tritrichomonas foetus and Pentatrichomonas hominis in intestinal tissue specimens of cats by chromogenic in situ hybridization. Vet Parasitol. 2012;183(3-4):209–14. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2011.07.050.\nSantos CS, Jesus VL, McIntosh D, Berto BP, Lopes CW. Co-infection by Tritrichomonas foetus and Pentatrichomonas hominis in asymptomatic cats. Pesquisa Veterinária Brasileira. 2015;35(12):980–8. https:\u002F\u002Fdoi.org\u002F10.1590\u002FS0100-736X2015001200007.\nLi WC, Wang K, Zhang W, Wu J, Gu YF, Zhang XC. Prevalence and molecular characterization of intestinal Trichomonads in pet dogs in East China. Korean J Parasitol. 2016;54(6):703–10. https:\u002F\u002Fdoi.org\u002F10.3347\u002Fkjp.2016.54.6.703.\nLi WC, Wang K, Li Y, Zhao LP, Xiao Y, Gu YF. Survey and molecular characterization of Trichomonads in pigs in Anhui Province, East China, 2014. Iran J Parasitol. 2018;13(4):602–10.\nLi W, Li W, Gong P, Meng Y, Li W, Zhang C, et al. Molecular and morphologic identification of Pentatrichomonas hominis in swine. Vet Parasitol. 2014;202(3-4):241–7. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2014.01.028.\nGrellet A. Brunopolack, Feugier a, Boucraut-Baralon C, Grandjean D, Vandewynckel L, et al. prevalence, risk factors of infection and molecular characterization of trichomonads in puppies from French breeding kennels. Vet Parasitol. 2013;197(3-4):418–26. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.vetpar.2013.07.030.\nYamamoto N, Kon M, Saito T, Maeno N, Koyama M, Sunaoshi K, et al. Prevalence of intestinal canine and feline parasites in Saitama prefecture, Japan. Kansenshogaku Zasshi. 2009;83(3):223–8. https:\u002F\u002Fdoi.org\u002F10.11150\u002Fkansenshogakuzasshi.83.223.\nItoh N, Iijima Y, Ogura I, Yonekura N, Kameshima S, Kimura Y. Molecular prevalence of trichomonad species from pet shop puppies and kittens in Japan. Revista Brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia. Veterinaria. 2020;29:e014820.\nInoue T, Hayashimoto N, Yasuda M, Sasaki E, Itoh T. Pentatrichomonas hominis in laboratory-bred common marmosets. Exp Anim. 2015;64(4):363–8. https:\u002F\u002Fdoi.org\u002F10.1538\u002Fexpanim.15-0010.\nKim YA, Kim HY, Cho SH, Cheun HI, Yu JR, Lee SE. PCR detection and molecular characterization of Pentatrichomonas hominis from feces of dogs with diarrhea in the Republic of Korea. Korean J Parasitol. 2010;48(1):9–13. https:\u002F\u002Fdoi.org\u002F10.3347\u002Fkjp.2010.48.1.9.\nMichalczyk M, Sokol R, Socha P. Detection of Pentatrichomonas hominis in dogs using real-time PCR. Pol J Vet Sci. 2015;18(4):775–8. https:\u002F\u002Fdoi.org\u002F10.1515\u002Fpjvs-2015-0100.\nRomatowski J. Pentatrichomonas hominis infection in four kittens. J Am Vet Med Assoc. 2000;216(8):1270–2. https:\u002F\u002Fdoi.org\u002F10.2460\u002Fjavma.2000.216.1270.\nGookin JL, Stauffer SH, Coccaro MR, Marcotte MJ, Levy MG. Optimization of a species-specific polymerase chain reaction assay for identification of Pentatrichomonas hominis in canine fecal specimens. Am J Vet Res. 2007;68(7):783–7. https:\u002F\u002Fdoi.org\u002F10.2460\u002Fajvr.68.7.783.\nKamaruddin M, Tokoro M, Rahman MM, Arayama S, Hidayati AP, Syafruddin D, et al. Molecular characterization of various trichomonad species isolated from humans and related mammals in Indonesia. Korean J Parasitol. 2014;52(5):471–8. https:\u002F\u002Fdoi.org\u002F10.3347\u002Fkjp.2014.52.5.471.\nLi W, Liu X, Gu Y, Liu J, Luo J. Prevalence of Cryptosporidium, Giardia, Blastocystis, and trichomonads in domestic cats in East China. J Vet Med Sci. 2019:19–0111.\nYao C, Köster LS. Tritrichomonas foetus infection, a cause of chronic diarrhea in the domestic cat. Vet Res. 2015;46(1):35. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13567-015-0169-0.",{"VOID":1485},"10.1186\u002Fs12917-021-02904-y","2024-06-26T23:07:12.347+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-021-02904-y",[1489,1504,1517,1532,1545,1558,1573,1588],{"id":1490,"sortIndex":19,"researcher":18,"roles":1491,"affiliations":1492,"properties":1501,"displayName":1503,"givenName":18,"familyName":18},"de8c848e-3f65-4cae-9cb7-2acfc6b71dae",[617],[1493],{"id":1494,"sortIndex":19,"affiliation":1495,"properties":18},"2163b8bf-73aa-415b-840d-0410b074950c",{"id":1494,"createTime":18,"updateTime":18,"relativeEntities":1496,"slug":18,"properties":1497,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1500,"statistic":18},[],{"title":1498},{"VI":1499},"Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand",[],{"title":1502},{"VI":1503},"Aongart Mahittikorn",{"id":1505,"sortIndex":141,"researcher":18,"roles":1506,"affiliations":1507,"properties":1514,"displayName":1516,"givenName":18,"familyName":18},"e99deead-c997-46da-8d8d-5f9d5b5070e2",[617],[1508],{"id":1494,"sortIndex":19,"affiliation":1509,"properties":18},{"id":1494,"createTime":18,"updateTime":18,"relativeEntities":1510,"slug":18,"properties":1511,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1513,"statistic":18},[],{"title":1512},{"VI":1499},[],{"title":1515},{"VI":1516},"Ruenruetai Udonsom",{"id":1518,"sortIndex":233,"researcher":18,"roles":1519,"affiliations":1520,"properties":1527,"displayName":1529,"givenName":18,"familyName":18},"a662733b-fb49-4e4a-a34a-9b18e8c72f94",[617],[1521],{"id":1494,"sortIndex":19,"affiliation":1522,"properties":18},{"id":1494,"createTime":18,"updateTime":18,"relativeEntities":1523,"slug":18,"properties":1524,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1526,"statistic":18},[],{"title":1525},{"VI":1499},[],{"title":1528,"gsAuthor":1530},{"VI":1529},"Khuanchai Koompapong",{"VOID":1531},"[\"W39BzWQAAAAJ\"]",{"id":1533,"sortIndex":253,"researcher":18,"roles":1534,"affiliations":1535,"properties":1542,"displayName":1544,"givenName":18,"familyName":18},"6140f3ad-0113-4f6c-b803-9d4f9009b321",[617],[1536],{"id":1494,"sortIndex":19,"affiliation":1537,"properties":18},{"id":1494,"createTime":18,"updateTime":18,"relativeEntities":1538,"slug":18,"properties":1539,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1541,"statistic":18},[],{"title":1540},{"VI":1499},[],{"title":1543},{"VI":1544},"Rachatawan Chiabchalard",{"id":1546,"sortIndex":273,"researcher":18,"roles":1547,"affiliations":1548,"properties":1555,"displayName":1557,"givenName":18,"familyName":18},"ade1f8fc-e937-4d13-a485-6c81edddc532",[617],[1549],{"id":1494,"sortIndex":19,"affiliation":1550,"properties":18},{"id":1494,"createTime":18,"updateTime":18,"relativeEntities":1551,"slug":18,"properties":1552,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1554,"statistic":18},[],{"title":1553},{"VI":1499},[],{"title":1556},{"VI":1557},"Chantira Sutthikornchai",{"id":1559,"sortIndex":688,"researcher":18,"roles":1560,"affiliations":1561,"properties":1570,"displayName":1572,"givenName":18,"familyName":18},"c5ce07ca-3ca9-456f-a4aa-48557a399cb1",[617],[1562],{"id":1563,"sortIndex":19,"affiliation":1564,"properties":18},"b7eedabf-af92-4603-b9f6-1115fe20dcde",{"id":1563,"createTime":18,"updateTime":18,"relativeEntities":1565,"slug":18,"properties":1566,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1569,"statistic":18},[],{"title":1567},{"EN":1568},"Faculty of Medical Technology, Rangsit University, Pathum Thani, Thailand",[],{"title":1571},{"VI":1572},"Preeyaporn Monatrakul Sreepian",{"id":1574,"sortIndex":702,"researcher":18,"roles":1575,"affiliations":1576,"properties":1585,"displayName":1587,"givenName":18,"familyName":18},"997fe60a-f463-4e6f-adf1-ca3a8682106a",[617],[1577],{"id":1578,"sortIndex":19,"affiliation":1579,"properties":18},"e0df8b56-b176-4cf3-8cc9-d233150c859b",{"id":1578,"createTime":18,"updateTime":18,"relativeEntities":1580,"slug":18,"properties":1581,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1584,"statistic":18},[],{"title":1582},{"VI":1583},"Department of General Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan",[],{"title":1586},{"VI":1587},"Hirotake Mori",{"id":1589,"sortIndex":101,"researcher":18,"roles":1590,"affiliations":1591,"properties":1598,"displayName":1600,"givenName":18,"familyName":18},"9ccfda46-58f7-447c-9b8c-c3dad1e41ae6",[617],[1592],{"id":1494,"sortIndex":19,"affiliation":1593,"properties":18},{"id":1494,"createTime":18,"updateTime":18,"relativeEntities":1594,"slug":18,"properties":1595,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1597,"statistic":18},[],{"title":1596},{"VI":1499},[],{"title":1599},{"VI":1600},"Supaluk Popruk",{"url":1487,"publisher":1602,"properties":1647},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1603,"slug":10,"properties":1604,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1607,"manageAffiliations":1616,"indexDatabases":1627,"url":18,"thumbnailPath":18,"statistic":1642,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1605,"eissn":1606},{"EN":13},{"VOID":15},[1608,1612],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1609,"label":1610,"description":1611,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1613,"label":1614,"description":1615,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[1617,1622],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":1618,"slug":18,"properties":1619,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1621,"statistic":18},[],{"title":1620},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":1623,"slug":18,"properties":1624,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1626,"statistic":18},[],{"title":1625},{"EN":46},[],[1628,1635],{"id":50,"indexDatabase":1629,"url":61,"indexYears":62,"academicFieldIds":1634,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":1630,"label":1631,"description":1632,"key":58,"publicationTags":1633,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":1636,"url":81,"indexYears":18,"academicFieldIds":1641,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":1637,"label":1638,"description":1639,"key":77,"publicationTags":1640,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":1643,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":1644,"totalCitation":121,"totalCitationByYear":1645,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":1646,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"pages":1648,"volume":1649},{"VOID":803},{"VOID":1650},"17",28,{"total":1651,"publishYear":1653,"statisticByYear":1654},2021,{"2021":141,"2022":688,"2023":253,"2024":729,"2025":1253,"2026":141},"2021-06-02","2026-07-28T08:16:07.195+00:00",[66,79],{"id":1659,"createTime":1660,"updateTime":1661,"relativeEntities":1662,"slug":1663,"properties":1664,"entityType":185,"verifyStatus":186,"verifyTime":1675,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1676,"fullTextUrl":1677,"authors":1678,"publicationType":289,"publisherRelationship":1817,"citationCount":19,"citationInfo":1868,"publishDate":1871,"publishYear":1869,"citationAnalyzeStatus":1872,"lastCitationAnalyze":1873,"indexDatabases":1874,"openAccess":18,"references":18,"isForceReanalyzing":595},"e2659a59-8f26-4081-813b-ad1bf78ff7cb","2024-01-29T12:44:00.130+00:00","2026-07-26T12:08:22.135+00:00",[],"High-diversity-of-genetic-lineages-and-virulence-genes-in-nasal-Staphylococcus-aureusisolates-from-donkeys-destined-to-food-consumption-in-Tunisia-with-predominance-of-the-ruminant-associated-CC133-lineage",{"abstract":1665,"title":1667,"gsPaper":1669,"references":1671,"doi":1673},{"EN":1666},"The objective of this study was to determine the genetic lineages and the incidence of antibiotic resistance and virulence determinants of nasal Staphylococcus aureus isolates of healthy donkeys destined to food consumption in Tunisia. Nasal swabs of 100 donkeys obtained in a large slaughterhouse in 2010 were inoculated in specific media for S. aureus and methicillin-resistant S. aureus (MRSA) recovery. S. aureus was obtained in 50% of the samples, being all of isolates methicillin-susceptible (MSSA). Genetic lineages, toxin gene profile, and antibiotic resistance mechanisms were determined in recovered isolates. Twenty-five different spa-types were detected among the 50 MSSA with 9 novel spa-types. S. aureus isolates were ascribed to agr type I (37 isolates), III (7), II (4), and IV (2). Sixteen different sequence-types (STs) were revealed by MLST, with seven new ones. STs belonging to clonal clomplex CC133 were majority. The gene tst was detected in 6 isolates and the gene etb in one isolate. Different combinations of enterotoxin, leukocidin and haemolysin genes were identified among S. aureus isolates. The egc-cluster-like and an incomplete egc-cluster-like were detected. Isolates resistant to penicillin, erythromycin, fusidic acid, streptomycin, ciprofloxacin, clindamycin, tetracycline, or chloramphenicol were found and the genes blaZ, erm(A), erm(C), tet(M), fusC were identified. The nares of donkeys frequently harbor MSSA. They could be reservoirs of the ruminant-associated CC133 lineage and of toxin genes encoding TSST-1 and other virulence traits with potential implications in public health. CC133 seems to have a broader host distribution than expected.",{"EN":1668},"High diversity of genetic lineages and virulence genes in nasal Staphylococcus aureusisolates from donkeys destined to food consumption in Tunisia with predominance of the ruminant associated CC133 lineage",{"VOID":1670},"[\"13179777460496218672\"]",{"VOID":1672},"citation_journal_title=Clin Microbiol Rev; citation_title=Exotoxins of Staphylococcus aureus; citation_author=MM Dinges, PM Orwin, PM Schlievert; citation_volume=13; citation_publication_date=2000; citation_pages=16-34; citation_doi=10.1128\u002FCMR.13.1.16-34.2000; citation_id=CR1\ncitation_journal_title=Microbiol Mol Biol Rev; citation_title=At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci; citation_author=GA Somerville, RA Proctor; citation_volume=73; citation_publication_date=2009; citation_pages=233-248; citation_doi=10.1128\u002FMMBR.00005-09; citation_id=CR2\ncitation_journal_title=Infect Immun; citation_title=Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles; citation_author=BC Kahl, G Belling, null Becker, I Chatterjee, K Wardecki, K Hilgert, AL Cheung, G Peters, M Herrmann; citation_volume=73; citation_publication_date=2005; citation_pages=4119-4126; citation_doi=10.1128\u002FIAI.73.7.4119-4126.2005; citation_id=CR3\ncitation_journal_title=Epidemiol Infect; citation_title=Methicillin-resistant Staphylococcus aureus (MRSA) in food production animals; citation_author=W Vanderhaeghen, K Hermans, F Haesebrouck, P Butaye; citation_volume=138; citation_publication_date=2010; citation_pages=606-625; citation_doi=10.1017\u002FS0950268809991567; citation_id=CR4\ncitation_journal_title=Food Pathog Dis; citation_title=Detection, molecular characterization, and clonal diversity of methicillin-resistant Staphylococcus aureus CC398 and CC97 in Spanish slaughter pigs of different age groups; citation_author=E Gómez-Sanz, C Torres, C Lozano, R Fernández-Pérez, C Aspiroz, F Ruiz-Larrea, M Zarazaga; citation_volume=7; citation_publication_date=2010; citation_pages=1269-1277; citation_doi=10.1089\u002Ffpd.2010.0610; citation_id=CR5\ncitation_journal_title=Trends Microbiol; citation_title=Livestock-associated Staphylococcus aureus: origin, evolution and public health threat; citation_author=JR Fitzgerald; citation_volume=20; citation_publication_date=2012; citation_pages=192-198; citation_doi=10.1016\u002Fj.tim.2012.01.006; citation_id=CR6\ncitation_journal_title=Frontiers Microbiol; citation_title=Methicillin-resistant Staphylococcus aureus associated with animals and its relevance to human health; citation_author=A Pantosti; citation_volume=3; citation_publication_date=2012; citation_pages=127; citation_doi=10.3389\u002Ffmicb.2012.00127; citation_id=CR7\ncitation_journal_title=Vet Microbiol; citation_title=Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine; citation_author=JS Weese, VE Duijkeren; citation_volume=140; citation_publication_date=2009; citation_pages=418-429; citation_doi=10.1016\u002Fj.vetmic.2009.01.039; citation_id=CR8\ncitation_journal_title=Can Vet J; citation_title=Staphylococcus aureus colonization in healthy horses in Atlantic Canada; citation_author=S Burton, R Reid-Smith, JT McClure, JS Weese; citation_volume=49; citation_publication_date=2008; citation_pages=797-799; citation_id=CR9\ncitation_journal_title=Vet Microbiol; citation_title=High occurrence of methicillin-resistantStaphylococcus aureusST398 in equine nasal samples; citation_author=A Van den Eede, A Martens, U Lipinska, M Struelens, A Deplano, O Denis, F Haesebrouck, F Gasthuys, K Hermans; citation_volume=133; citation_publication_date=2009; citation_pages=138-144; citation_doi=10.1016\u002Fj.vetmic.2008.06.021; citation_id=CR10\ncitation_title=Detection of methicillin-resistantStaphylococcus aureus (MRSA) in the microbial flora from the conjunctiva of healthy donkeys from Sicily (Italy); citation_inbook_title=Vet Ophthalmol; citation_publication_date=2012; citation_pages=1463-5224; citation_id=CR11; citation_author=M Foti; citation_author=V Fisichella; citation_author=C Giacopello\ncitation_journal_title=Int J Appl Res Vet Med; citation_title=Isolation and identification of aerobic bacterial flora from the upper respiratory tract of donkeys in Central Ethiopia; citation_author=DF Gutema, BE Duguma, AG Dinka; citation_volume=7; citation_publication_date=2009; citation_pages=181-189; citation_id=CR12\ncitation_journal_title=J Dairy Res; citation_title=Hygienic and health characteristics of donkey milk during a follow-up study; citation_author=R Pilla, V Dapra, A Zecconi, R Piccinini; citation_volume=77; citation_publication_date=2010; citation_pages=392-397; citation_doi=10.1017\u002FS0022029910000221; citation_id=CR13\ncitation_journal_title=Meat Sci; citation_title=Quality of donkey meat and carcass characteristics; citation_author=P Polidori, S Vincenzetti, C Cavallucci, D Beghelli; citation_volume=80; citation_publication_date=2008; citation_pages=1222-1224; citation_doi=10.1016\u002Fj.meatsci.2008.05.027; citation_id=CR14\ncitation_journal_title=Sing J Trop Geog; citation_title=Distribution and importance of the domestic donkey in circumsaharan Africa; citation_author=RT Wilson; citation_volume=2; citation_publication_date=1978; citation_pages=136-143; citation_doi=10.1111\u002Fj.1467-9493.1981.tb00126.x; citation_id=CR15\ncitation_journal_title=Empowering Farmers with Animal Traction (Proceedings of an ATNESA Workshop); citation_title=Empowering people through donkey power into the next millennium; citation_author=EM Nengomasha, RA Pearson, AG Wold; citation_volume=21; citation_publication_date=2000; citation_pages=22-31; citation_id=CR16\ncitation_journal_title=J Clin Microbiol; citation_title=Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureus; citation_author=B Walther, S Monecke, C Ruscher, AW Friedrich, R Ehricht, P Slickers, A Soba, CG Wleklinski, LH Wieler, A Lubke-Becker; citation_volume=47; citation_publication_date=2009; citation_pages=704-710; citation_doi=10.1128\u002FJCM.01626-08; citation_id=CR17\ncitation_title=Performance standards for antimicrobial susceptibility testing; eighteenth informational supplement; citation_publication_date=2010; citation_id=CR18; citation_publisher=CLSI document M100-18 CLSI\ncitation_journal_title=J Antimicrob Chemother; citation_title=Antimicrobial activity and mechanisms of resistance to cepahalosporin P1, an antibiotic related to fusidic acid; citation_author=AJ O’Neill, M Bostock, AM Moita, I Chopra; citation_volume=50; citation_publication_date=2002; citation_pages=839-848; citation_doi=10.1093\u002Fjac\u002Fdkf248; citation_id=CR19\ncitation_journal_title=J Clin Microbiol; citation_title=Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management; citation_author=D Harmsen, H Claus, W Witte, J Rothganger, H Claus, D Turnwald, U Vogel; citation_volume=41; citation_publication_date=2003; citation_pages=5442-5448; citation_doi=10.1128\u002FJCM.41.12.5442-5448.2003; citation_id=CR20\ncitation_journal_title=Clin Infect Dis; citation_title=Hospital-acquired and community-derived: the future of MRSA?; citation_author=B Shopsin, S Herring, BN Kreiswirth; citation_volume=37; citation_publication_date=2003; citation_pages=151-152; citation_doi=10.1086\u002F375608; citation_id=CR21\ncitation_journal_title=Gen Biol Evol; citation_title=Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation; citation_author=CM Guinane, NL Ben Zakour, MA Tormo-Mas, LA Weinert, BV Lowder, RA Cartwright, DS Smyth, CJ Smyth, JA Lindsay, KA Gould, A Witney, J Hindsb, JP Bollback, A Rambaut, JR Penadés, JR Fitzgerald; citation_volume=2; citation_publication_date=2010; citation_pages=454-466; citation_doi=10.1093\u002Fgbe\u002Fevq031; citation_id=CR22\ncitation_journal_title=Int J Food Microbiol; citation_title=Novel multiplex PCR for the detection of the Staphylococcus aureus superantigen and its application to raw meat isolates in Korea; citation_author=SY Hwang, SH Kim, EJ Jang, NH Kwon, YK Park, HC Koo, WK Jung, JM Kim, YH Park; citation_volume=117; citation_publication_date=2007; citation_pages=99-105; citation_doi=10.1016\u002Fj.ijfoodmicro.2007.02.013; citation_id=CR23\ncitation_journal_title=Infect Immun; citation_title=Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease; citation_author=S Jarraud, C Mougel, J Thioulouse, G Lina, H Meugnier, F Forey, X Nesme, J Etienne, F Vandenesch; citation_volume=70; citation_publication_date=2002; citation_pages=631-641; citation_doi=10.1128\u002FIAI.70.2.631-641.2002; citation_id=CR24\ncitation_journal_title=PLoS Med; citation_title=Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis; citation_author=H Grundmann, DM Aanensen, CC Van den Wijngaard, BG Spratt, D Harmsen, AW Friedrich; citation_volume=7; citation_publication_date=2010; citation_pages=1-e1000215; citation_doi=10.1371\u002Fjournal.pmed.1000215; citation_id=CR25\ncitation_journal_title=J Med Microbiol; citation_title=Multilocus sequence typing of Staphylococcus aureus isolates recovered from cows with mastitis in Brazilian dairy herds; citation_author=RF Rabello, BM Moreira, RMM Lopes, LM Teixeira, LW Riley, ACD Castro; citation_volume=56; citation_publication_date=2007; citation_pages=1505-1511; citation_doi=10.1099\u002Fjmm.0.47357-0; citation_id=CR26\ncitation_journal_title=Vet Microbiol; citation_title=spa type distribution in Staphylococcus aureus originating from pigs, cattle and poultry; citation_author=H Hasman, A Moodley, L Guardabassi, M Stegger, RL Skov, FM Aarestrup; citation_volume=141; citation_publication_date=2010; citation_pages=326-331; citation_doi=10.1016\u002Fj.vetmic.2009.09.025; citation_id=CR27\ncitation_journal_title=Vet Microbiol; citation_title=Clonal diversity of Staphylococcus aureus originating from the small ruminants goats and sheep; citation_author=MC Porrero, H Hasman, AI Vela, JF Fernández-Garayzábal, L Domínguez, FM Aarestrup; citation_volume=156; citation_publication_date=2012; citation_pages=157-161; citation_doi=10.1016\u002Fj.vetmic.2011.10.015; citation_id=CR28\ncitation_journal_title=Vet Microbiol; citation_title=Prevalence, antibiotic resistance, virulence traits and genetic lineages of Staphylococcus aureus in healthy sheep in Tunisia; citation_author=H Gharsa, K Ben Slama, C Lozano, E Gómez-Sanz, N Klibi, R Ben Sallem, P Gómez, M Zarazaga, A Boudabous, C Torres; citation_volume=156; citation_publication_date=2011; citation_pages=367-373; citation_doi=10.1016\u002Fj.vetmic.2011.11.009; citation_id=CR29\ncitation_journal_title=J Dairy Res; citation_title=Novel sequence types (STs) of Staphylococcus aureus isolates causing clinical and subclinical mastitis in flocks of sheep in the northeast of brazil; citation_author=LM Almeida, MZ Almeida, CL Mendonça, EM Mamizuka; citation_volume=78; citation_publication_date=2011; citation_pages=373-378; citation_doi=10.1017\u002FS0022029911000379; citation_id=CR30\ncitation_journal_title=Vet Microbiol; citation_title=Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle; citation_author=S Monecke, P Kuhnert, H Hotzel, P Slickers, R Ehricht; citation_volume=125; citation_publication_date=2007; citation_pages=128-140; citation_doi=10.1016\u002Fj.vetmic.2007.05.016; citation_id=CR31\ncitation_title=Occurrence and distribution of Staphylococcus aureus lineages among zoo animals; citation_inbook_title=Vet Microbiol; citation_publication_date=2012; citation_id=CR32; citation_author=C Espinosa-Gongora; citation_author=D Chrobak; citation_author=A Moodley; citation_author=MF Bertelsen; citation_author=L Guardabassi\ncitation_journal_title=Microbiol; citation_title=Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multi-strain microarray; citation_author=JML Sung, DH Lloyd, JA Lindsay; citation_volume=154; citation_publication_date=2008; citation_pages=1949-1959; citation_doi=10.1099\u002Fmic.0.2007\u002F015289-0; citation_id=CR33\ncitation_journal_title=J Antimicrob Chemother; citation_title=Molecular characterization of spa type t127, sequence type 1 methicillin-resistant Staphylococcus aureus from pigs; citation_author=A Franco, H Hasman, M Iurescia, R Lorenzetti, M Stegger, A Pantosti, F Feltrin, A Ianzano, MC Porrero, M Liap, A Battist; citation_volume=66; citation_publication_date=2011; citation_pages=1231-5; citation_doi=10.1093\u002Fjac\u002Fdkr115; citation_id=CR34\ncitation_journal_title=J Clin Microbiol; citation_title=Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities; citation_author=M McDonald, A Dougall, D Holt, F Huygens, F Oppedisano, PM Giffard, J Inman-Bamber, AJ Stephens, R Towers, JR Carapetis, BJ Currie; citation_volume=44; citation_publication_date=2006; citation_pages=3720-3727; citation_doi=10.1128\u002FJCM.00836-06; citation_id=CR35\ncitation_journal_title=J Med Microbiol; citation_title=Molecular typing of nasal carriage isolates of Staphylococcus aureus from an Irish university student population based on toxin gene PCR, agr locus types and multiple locus, variable number tandem repeat analysis; citation_author=MM Collery, DS Smyth, JM Twohig, AC Shore, DC Coleman, CJ Smyth; citation_volume=57; citation_publication_date=2008; citation_pages=348-358; citation_doi=10.1099\u002Fjmm.0.47734-0; citation_id=CR36\ncitation_journal_title=J Med Microbiol; citation_title=Associations between enterotoxin gene cluster types egc1, egc2 and egc3, agr types, enterotoxin and enterotoxin-like gene profiles, and molecular typing characteristics of human nasal carriage and animal isolates of Staphylococcus aureus; citation_author=MM Collery, DS Smyth, JJG Tumilty, JM Twohig, CJ Smyth; citation_volume=58; citation_publication_date=2009; citation_pages=13-25; citation_doi=10.1099\u002Fjmm.0.005215-0; citation_id=CR37\ncitation_journal_title=BMC Microbiol; citation_title=Evolution and diversity of community-associated methicillin-resistant Staphylococcus aureus in a geographical region; citation_author=GW Coombs, S Monecke, JC Pearson, H Tan, YK Chew, L Wilson, R Ehricht, FG O’Brien, KJ Christiansen; citation_volume=11; citation_publication_date=2011; citation_pages=215-227; citation_doi=10.1186\u002F1471-2180-11-215; citation_id=CR38\ncitation_journal_title=J Med Microbiol; citation_title=Molecular typing of Staphylococcus aureus blood stream isolates from geriatric patients attending a long-term care Spanish hospital; citation_author=MA Argudín, C Mendoza, A Vazquez, B Guerra, MR Rodicio; citation_volume=60; citation_publication_date=2011; citation_pages=172-179; citation_doi=10.1099\u002Fjmm.0.021758-0; citation_id=CR39\ncitation_journal_title=J Clin Microbiol; citation_title=Clonal complexes and diversity of exotoxin gene profiles in methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates from patients in a Spanish Hospital; citation_author=MA Argudín, MC Mendoza, FJ Méndez, MC Martín, B Guerra, MR Rodicio; citation_volume=47; citation_publication_date=2009; citation_pages=2097-2105; citation_doi=10.1128\u002FJCM.01486-08; citation_id=CR40\ncitation_journal_title=Int J Med Microbiol; citation_title=Methicillin-susceptible Staphylococcus aureus from clinical and community sources are genetically diverse; citation_author=H Ghasemzadeh-Moghaddama, E Ghaznavi-Rada, Z Sekawia, L Yun-Khoona, MN Azizc, RA Hamata, DC Mellesd, AV Belkumd, MN Shamsudina, V Neela; citation_volume=30; citation_publication_date=2011; citation_pages=347-353; citation_doi=10.1016\u002Fj.ijmm.2010.10.004; citation_id=CR41\ncitation_journal_title=Clin Microbiol Infect; citation_title=Epidemiology of methicillin susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton–Valentine leukocidin genes; citation_author=S Breurec, C Fall, R Pouillot, P Boisier, S Brisse, F Diene-Sarr, S Djibo, JM Etienne, C Fonkoua, JD Perrier-Gros-Claude, CE Ramarokoto, FJ Randrianirina, M Thiberge, SB Zriouil, B Garin, F Laurent; citation_volume=17; citation_publication_date=2010; citation_pages=633-639; citation_doi=10.1111\u002Fj.1469-0691.2010.03320.x; citation_id=CR42\ncitation_journal_title=J Antimicrob Chemother; citation_title=Spa typing of methicillin-resistant Staphylococcus aureus isolated from domestic animals and veterinary staff in the UK and Ireland; citation_author=A Moodley, M Stegger, AF Bagcigil, KE Baptiste, A Loeffler, DH Lloyd, NJ Williams, N Leonard, Y Abbott, R Skov, L Guardabassi; citation_volume=58; citation_publication_date=2006; citation_pages=1118-1123; citation_doi=10.1093\u002Fjac\u002Fdkl394; citation_id=CR43\ncitation_journal_title=Eur J Clin Microbiol Infect Dis; citation_title=Nasal carriage ofStaphylococcus aureus in healthy humans with different levels of contact with animals in Tunisia: genetic lineages, methicillin resistance, and virulence factors; citation_author=K Ben Slama, H Gharsa, N Klibi, A Jouini, C Lozano, E Gómez-Sanz, M Zarazaga, A Boudabous, C Torres; citation_volume=30; citation_publication_date=2011; citation_pages=499-508; citation_doi=10.1007\u002Fs10096-010-1109-6; citation_id=CR44\ncitation_journal_title=Int J Med Microbiol; citation_title=Staphylococcus aureus nasal carriage, virulence traits, antibiotic resistance mechanisms, and genetic lineages in healthy humans in Spain, with detection of CC398 and CC97 strains; citation_author=C Lozano, E Gómez-Sanz, D Benito, C Aspiroz, M Zarazaga, C Torres; citation_volume=301; citation_publication_date=2011; citation_pages=500-505; citation_doi=10.1016\u002Fj.ijmm.2011.02.004; citation_id=CR45\ncitation_journal_title=J Med Microbiol; citation_title=Superantigen genes encoded by the egc cluster and SaPIbov are predominant among Staphylococcus aureus isolates from cows, goats, sheep, rabbits and poultry; citation_author=DS Smyth, PJ Hartigan, WJ Meaney, JR Fitzgerald, CF Deobald, GA Bohach, CJ Smyth; citation_volume=54; citation_publication_date=2005; citation_pages=401-411; citation_doi=10.1099\u002Fjmm.0.45863-0; citation_id=CR46\ncitation_journal_title=PLoS One; citation_title=High throughput multiple locus variable number of tandem repeat analysis (MLVA) of Staphylococcus aureus from human, animal and food sources; citation_author=D Sobral, S Schwarz, D Bergonier, A Brisabois, AT Feßler, FB Gilbert, K Kadlec, B Lebeau, F Loisy-Hamon, M Treilles, C Pourcel, G Vergnaud; citation_volume=7; citation_publication_date=2012; citation_pages=e33967; citation_doi=10.1371\u002Fjournal.pone.0033967; citation_id=CR47\ncitation_journal_title=Antimicrob Agents Chemother; citation_title=Fusidic acid resistance determinants in Staphylococcus aureus clinical isolates; citation_author=HJ Chen, WC Hung, SP Tseng, JC Tsai, PR Hsueh, LJ Teng; citation_volume=54; citation_publication_date=2010; citation_pages=4985-4991; citation_doi=10.1128\u002FAAC.00523-10; citation_id=CR48",{"VOID":1674},"10.1186\u002F1746-6148-8-203","2024-08-30T20:04:54.953+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1186\u002F1746-6148-8-203","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Fcounter\u002Fpdf\u002F10.1186\u002F1746-6148-8-203",[1679,1696,1709,1724,1739,1752,1765,1778,1791,1804],{"id":1680,"sortIndex":19,"researcher":18,"roles":1681,"affiliations":1682,"properties":1691,"displayName":1693,"givenName":18,"familyName":18},"e4003cb7-f203-4e45-8c15-ab459633bf14",[617],[1683],{"id":1684,"sortIndex":19,"affiliation":1685,"properties":18},"4b14eee4-abee-4165-9b08-2b7a0f494a73",{"id":1684,"createTime":18,"updateTime":18,"relativeEntities":1686,"slug":18,"properties":1687,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1690,"statistic":18},[],{"title":1688},{"VI":1689},"Laboratoire des Microorganismes et Biomolécules Actives, Faculté des Sciences de Tunis, Université Tunis El Manar, Tunis, Tunisia",[],{"title":1692,"gsAuthor":1694},{"VI":1693},"Gharsa, Haythem",{"VOID":1695},"[\"Pqdqeu0AAAAJ\"]",{"id":1697,"sortIndex":141,"researcher":18,"roles":1698,"affiliations":1699,"properties":1706,"displayName":1708,"givenName":18,"familyName":18},"b8122379-3e6c-47b7-a4b6-e7eeb0cf6056",[617],[1700],{"id":1684,"sortIndex":19,"affiliation":1701,"properties":18},{"id":1684,"createTime":18,"updateTime":18,"relativeEntities":1702,"slug":18,"properties":1703,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1705,"statistic":18},[],{"title":1704},{"VI":1689},[],{"title":1707},{"VI":1708},"Ben Sallem, Rym",{"id":1710,"sortIndex":233,"researcher":18,"roles":1711,"affiliations":1712,"properties":1719,"displayName":1721,"givenName":18,"familyName":18},"a71f8456-2787-469b-a695-5da2b37c75b0",[617],[1713],{"id":1684,"sortIndex":19,"affiliation":1714,"properties":18},{"id":1684,"createTime":18,"updateTime":18,"relativeEntities":1715,"slug":18,"properties":1716,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1718,"statistic":18},[],{"title":1717},{"VI":1689},[],{"title":1720,"gsAuthor":1722},{"VI":1721},"Ben Slama, Karim",{"VOID":1723},"[\"V_BbopoAAAAJ\"]",{"id":1725,"sortIndex":253,"researcher":18,"roles":1726,"affiliations":1727,"properties":1736,"displayName":1738,"givenName":18,"familyName":18},"c6d8844d-402e-421b-8e9f-22fd3b554900",[617],[1728],{"id":1729,"sortIndex":19,"affiliation":1730,"properties":18},"0f73c8a6-09b2-4112-8acf-d10cc49ef05c",{"id":1729,"createTime":18,"updateTime":18,"relativeEntities":1731,"slug":18,"properties":1732,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1735,"statistic":18},[],{"title":1733},{"VI":1734},"Departamento de Agricultura y Alimentación, Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain",[],{"title":1737},{"VI":1738},"Gómez-Sanz, Elena",{"id":1740,"sortIndex":273,"researcher":18,"roles":1741,"affiliations":1742,"properties":1749,"displayName":1751,"givenName":18,"familyName":18},"45a908a9-9f99-4d6d-ad5b-62d90e4b2910",[617],[1743],{"id":1729,"sortIndex":19,"affiliation":1744,"properties":18},{"id":1729,"createTime":18,"updateTime":18,"relativeEntities":1745,"slug":18,"properties":1746,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1748,"statistic":18},[],{"title":1747},{"VI":1734},[],{"title":1750},{"VI":1751},"Lozano, Carmen",{"id":1753,"sortIndex":688,"researcher":18,"roles":1754,"affiliations":1755,"properties":1762,"displayName":1764,"givenName":18,"familyName":18},"d0e7d5ae-56e5-493c-beea-391c51a84767",[617],[1756],{"id":1684,"sortIndex":19,"affiliation":1757,"properties":18},{"id":1684,"createTime":18,"updateTime":18,"relativeEntities":1758,"slug":18,"properties":1759,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1761,"statistic":18},[],{"title":1760},{"VI":1689},[],{"title":1763},{"VI":1764},"Jouini, Ahlem",{"id":1766,"sortIndex":702,"researcher":18,"roles":1767,"affiliations":1768,"properties":1775,"displayName":1777,"givenName":18,"familyName":18},"fb157bdf-f8f8-45f8-9c4e-265ffc9cb743",[617],[1769],{"id":1684,"sortIndex":19,"affiliation":1770,"properties":18},{"id":1684,"createTime":18,"updateTime":18,"relativeEntities":1771,"slug":18,"properties":1772,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1774,"statistic":18},[],{"title":1773},{"VI":1689},[],{"title":1776},{"VI":1777},"Klibi, Naouel",{"id":1779,"sortIndex":101,"researcher":18,"roles":1780,"affiliations":1781,"properties":1788,"displayName":1790,"givenName":18,"familyName":18},"bd41bbfc-5c19-4cc3-b671-4a4905214b53",[617],[1782],{"id":1729,"sortIndex":19,"affiliation":1783,"properties":18},{"id":1729,"createTime":18,"updateTime":18,"relativeEntities":1784,"slug":18,"properties":1785,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1787,"statistic":18},[],{"title":1786},{"VI":1734},[],{"title":1789},{"VI":1790},"Zarazaga, Myriam",{"id":1792,"sortIndex":729,"researcher":18,"roles":1793,"affiliations":1794,"properties":1801,"displayName":1803,"givenName":18,"familyName":18},"f6db469c-8686-4c41-b83f-b6fadede207e",[617],[1795],{"id":1684,"sortIndex":19,"affiliation":1796,"properties":18},{"id":1684,"createTime":18,"updateTime":18,"relativeEntities":1797,"slug":18,"properties":1798,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1800,"statistic":18},[],{"title":1799},{"VI":1689},[],{"title":1802},{"VI":1803},"Boudabous, Abdellatif",{"id":1805,"sortIndex":743,"researcher":18,"roles":1806,"affiliations":1807,"properties":1814,"displayName":1816,"givenName":18,"familyName":18},"bc6ab055-a627-4bff-ad6f-dc8b4fcf5f04",[617],[1808],{"id":1729,"sortIndex":19,"affiliation":1809,"properties":18},{"id":1729,"createTime":18,"updateTime":18,"relativeEntities":1810,"slug":18,"properties":1811,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1813,"statistic":18},[],{"title":1812},{"VI":1734},[],{"title":1815},{"VI":1816},"Torres, Carmen",{"url":1676,"publisher":1818,"properties":1863},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1819,"slug":10,"properties":1820,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1823,"manageAffiliations":1832,"indexDatabases":1843,"url":18,"thumbnailPath":18,"statistic":1858,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":1821,"eissn":1822},{"EN":13},{"VOID":15},[1824,1828],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1825,"label":1826,"description":1827,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":1829,"label":1830,"description":1831,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[1833,1838],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":1834,"slug":18,"properties":1835,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1837,"statistic":18},[],{"title":1836},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":1839,"slug":18,"properties":1840,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1842,"statistic":18},[],{"title":1841},{"EN":46},[],[1844,1851],{"id":50,"indexDatabase":1845,"url":61,"indexYears":62,"academicFieldIds":1850,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":1846,"label":1847,"description":1848,"key":58,"publicationTags":1849,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":1852,"url":81,"indexYears":18,"academicFieldIds":1857,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":1853,"label":1854,"description":1855,"key":77,"publicationTags":1856,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":1859,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":1860,"totalCitation":121,"totalCitationByYear":1861,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":1862,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"issue":1864,"pages":1865,"volume":1866},{"VOID":338},{"VOID":1461},{"VOID":1867},"8",{"total":19,"publishYear":1869,"statisticByYear":1870},2012,{},"2012-12-01","DONE_ANALYZE_CITATION","2026-07-26T12:08:22.134+00:00",[66,79],{"id":1876,"createTime":1877,"updateTime":1878,"relativeEntities":1879,"slug":1880,"properties":1881,"entityType":185,"verifyStatus":186,"verifyTime":1894,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1895,"fullTextUrl":18,"authors":1896,"publicationType":289,"publisherRelationship":2024,"citationCount":19,"citationInfo":2070,"publishDate":2072,"publishYear":807,"citationAnalyzeStatus":1872,"lastCitationAnalyze":2073,"indexDatabases":2074,"openAccess":18,"references":18,"isForceReanalyzing":595},"c7bce09e-1a37-4368-812e-2a28c4ccc862","2024-04-06T06:57:38.111+00:00","2026-07-25T19:08:44.243+00:00",[],"Diagnosis-of-acute-canine-leptospirosis-using-multiple-laboratory-tests-and-characterization-of-the-isolated-strains",{"abstract":1882,"title":1884,"gsPaper":1886,"keywords":1888,"references":1890,"doi":1892},{"EN":1883},"Dogs presenting with acute leptospirosis may present non-specific clinical and laboratory findings, and the definitive diagnosis may require additional confirmatory tests, including bacterial culture, for the direct or indirect identification of the pathogen. The present study describes the diagnosis of leptospirosis in suspected dogs based on the use of multiple diagnostic tests, including serological, molecular and bacteriological tests, along with the characterization of the recovered leptospiral strains. Urine, serum and blood samples were collected from 33 dogs with suspected clinical leptospirosis treated at the University of São Paulo Veterinary Hospital Service (Hovet FMVZ-USP) between 2013 and 2016. Only dogs with high blood urea nitrogen and creatinine levels in association with multiple clinical manifestations of the disease were included. Leptospiral culture, PCR and serology (Microscopic agglutination test - MAT) were performed in blood and urine samples taken from all suspected dogs at clinical presentation, and an additional prospective MAT titration was performed in seven dogs. Infection could be identified exclusively by PCR in 10 dogs (30.3%), exclusively by MAT in four dogs (12.1%) and by both tests in four dogs, totaling 18 dogs (54.5–95%CI: 37.6–71.5). Six out of eight MAT-confirmed cases presented with the highest titers against the Icterohaemorrhagiae serogroup. Leptospires were recovered from urine samples from two PCR-positive dogs, and both strains could be characterized by Multilocus Sequence Analysis and serogrouping as L. interrogans serogroup Icterohaemorrhagiae. Both isolates were shown to be pathogenic in the hamster model. The simultaneous use of MAT and PCR was able to increase the diagnosis of leptospirosis in clinically suspected cases. Despite the increasing incidence of new serovars affecting dogs being reported in different locations, our results suggest that leptospiral strains belonging to the Icterohaemorrhagiae serogroup are still a major causative agent of canine leptospirosis in São Paulo, Brazil.",{"EN":1885},"Diagnosis of acute canine leptospirosis using multiple laboratory tests and characterization of the isolated strains",{"VOID":1887},"[\"16194944934666891166\"]",{"EN":1889},"",{"VOID":1891},"Schuller S, Francey T, Hartmann K, Hugonnard M, Kohn B, Nally JE, Sykes J. European consensus statement on leptospirosis in dogs and cats. J Small Anim Pract. 2015;56:159–79.\nAzocar-Aedo L, Monti G. Meta-analyses of factors associated with leptospirosis in domestic dogs. Zoonoses Public Health. 2016;63:328–36.\nHartskeerl RA, Collares-Pereira M, Ellis WA. Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world. Clin Microbiol Infect. 2011;17:494–501.\nAndre-Fontaine G. Canine leptospirosis - do we have a problem? Vet Microbiol. 2006;117:19–24.\nFraune CK, Schweighauser A, Francey T. Evaluation of the diagnostic value of serologic microagglutination testing and a polymerase chain reaction assay for diagnosis of acute leptospirosis in dogs in a referral center. J Am Vet Med Assoc. 2013;242:1373–80.\nHarkin KR, Roshto YM, Sullivan JT, Purvis TJ, Chengappa MM. Comparison of polymerase chain reaction assay, bacteriologic culture, and serologic testing in assessment of prevalence of urinary shedding of leptospires in dogs. J Am Vet Med Assoc. 2003;222:1230–3.\nPenna B, Marassi CD, Libonati H, Narduche L, Lilenbaum W, Bourhy P. Diagnostic accuracy of an in-house ELISA using the intermediate species Leptospira fainei as antigen for diagnosis of acute leptospirosis in dogs. Comp Immunol Microbiol Infect Dis. 2017;50:13–5.\nGloor CI, Schweighauser A, Francey T, Rodriguez-Campos S, Vidondo B, Bigler B, Schuller S. Diagnostic value of two commercial chromatographic “patient-side” tests in the diagnosis of acute canine leptospirosis. J Small Anim Pract. 2017;58:154–61.\nSchuller S, Callanan JJ, Worrall S, Francey T, Schweighauser A, Kohn B, Klopfleisch R, Posthaus H, Nally JE. Immunohistochemical detection of IgM and IgG in lung tissue of dogs with leptospiral pulmonary haemorrhage syndrome (LPHS). Comp Immunol Microbiol Infect Dis. 2015;40:47–53.\nLevett PN. Usefulness of serologic analysis as a predictor of the infecting serovar in patients with severe leptospirosis. Clin Infect Dis. 2003;36:447–52.\nHarkin KR, Roshto YM, Sullivan JT. Clinical application of a polymerase chain reaction assay for diagnosis of leptospirosis in dogs. J Am Vet Med Assoc. 2003;222:1224–9.\nMiotto BA, Moreno LZ, Guilloux AGA, de Sousa GO, Loureiro AP, Moreno AM, Lilenbaum W, Vasconcellos SA, Heinemann MB, Hagiwara MK. Molecular and serological characterization of the first Leptospira santarosai strain isolated from a dog. Acta Trop. 2016;162:1–4.\nda Cunha CEP, Felix SR, Neto ACPS, Campello-Felix A, Kremer FS, Monte LG, Amaral MG, de Oliveira Nobre M, da Silva ÉF, Hartleben CP, McBride AJ, Dellagostin OA. Infection with Leptospira kirschneri serovar Mozdok: first report from the southern hemisphere. Am J Trop Med Hyg. 2016;94:519–21.\nKoizumi N, Muto MM, Akachi S, Okano S, Yamamoto S, Horikawa K, Harada S, Funatsumaru S, Ohnishi M. Molecular and serological investigation of Leptospira and leptospirosis in dogs in Japan. J Med Microbiol. 2013;62:630–6.\nRodrigues AMA, Vasconcellos SA, de Moraes ZM, Hagiwara MK. Isolation of Leptospira Spp. from dogs with clinical suspect of leptospirosis in São Paulo (Brazil). Acta Sci Vet. 2007;2:705–6.\nMiraglia F, Morais ZM, Dellagostin OA, Seixas FK, Freitas JC, Zacarias FG, Delbem AC, Ferreira TS, Souza GO, Hartskeerl RA, Vasconcellos SA, Moreno AM. Molecular and serological characterization of Leptospira interrogans serovar Canicola isolated from dogs, swine, and bovine in Brazil. Trop Anim Health Prod. 2012;45:117–21.\nWorld Organization for Animal Health. Leptospirosis: Guidance for Diagnosis, Surveillance and Control; 2012. p. 57–72.\nMérien F, Amouriaux P, Perolat P, Baranton G, Saint Girons I. Polymerase chain reaction for detection of Leptospira spp. in clinical samples. J Clin Microbiol. 1992;30:2219–24.\nDikken H, Kmety E. Chapter VIII serological typing methods of leptospires. In: TBAJR N, editor. Methods Microbiol Academic Press; 1978. p. 259–307T2.\nBoonsilp S, Thaipadungpanit J, Amornchai P, Wuthiekanun V, Chierakul W, Limmathurotsakul D, Day NP, Peacock SJ. Molecular detection and speciation of pathogenic Leptospira spp. in blood from patients with culture-negative leptospirosis. BMC Infect Dis. 2011;11:338.\nJorge S, Monte LG, Oliveira NR, Collares TF, Roloff BC, Gomes CK, Hartwig DD, Dellagostin OA, Hartleben CP. Phenotypic and molecular characterization of Leptospira interrogans isolated from Canis familiaris in southern Brazil. Curr Microbiol. 2015;71:496–500.\nFink JM, Moore GE, Landau R, Vemulapalli R. Evaluation of three 5’ exonuclease-based real-time polymerase chain reaction assays for detection of pathogenic Leptospira species in canine urine. J Vet Diagn Investig. 2015;27:159–66.\nMiraglia F, Matsuo M, Morais ZM, Dellagostin OA, Seixas FK, Freitas JC, Hartskeerl R, Moreno LZ, Costa BL, Souza GO, Vasconcellos SA, Moreno AM. Molecular characterization, serotyping, and antibiotic susceptibility profile of Leptospira interrogans serovar Copenhageni isolates from Brazil. Diag Microbiol Infec Dis. 2013;77:195–9.\nSantana WJ, Santos AS, Azevedo ZFT, Macedo JO, Solcá M, Camaroti P, Tourinho M, fraga DBM, Cerqueira RB, Mcbride FWC. Levantamento epidemiológico da leptospirose canina em animais atendidos no Hospital Veterinário da Unime na cidade de Lauro de Freitas, Bahia. In: Congresso Brasileiro De Medicina Veterinária, 35; Conbravet, 5; Congresso De Medicina Veterinária Do Cone Sul, 2008. Gramado: Anais; 2008.\nFreire IMA, Varges RG, Gomes YN, Pombo CR, Lilembaun W. Distribuição dos serovares de Leptospira em caninos clinicamente suspeitos no Rio De Janeiro. R Bras Ci Vet. 2007;14:83–5.\nMorikawa VM, Bier D, Pellizzaro M, Ullmann LS, Paploski IAD, Kikuti M, Langoni H, Biondo AW, Molento MB. Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in southern Brazil. Rev Soc Bras Med Trop. 2015;48:50–5.\nQuerino AMV, Delbem ÁCB, de Oliveira RC, Silva FGD, Müller EE, Freire RL, Freitas JC. Fatores de risco associados à leptospirose em cães do município de Londrina-PR. Sem Ci Agr. 2003;24:27–34.\nFelzemburgh RDM, Ribeiro GS, Costa F, Reis RB, Hagan JE, Melendez AX, Fraga D, Santana FS, Mohr S, dos Santos BL, Silva AQ, Santos AC, Ravines RR, Tassinari WS, Carvalho MS, Reis MG, Ko AI. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the Leptospira agent. PLoS Negl Trop Dis. 2014;8:e2927–9.\nBlanco RM, Romero EC. Fifteen years of human leptospirosis in São Paulo, Brazil. J Epidemiolol Res. 2015;2:56–6.\nRomero EC, Bernardo CCDM, Yasuda PH. Human leptospirosis: a twenty-nine-year serological study in São Paulo, Brazil. Rev Inst Med trop S Paulo. 2003;45:245–8.\nOliveira MAA, Leal ÉA, Correia MA, Filho JCS, Dias RS, Serufo JC. Human leptospirosis: occurrence of serovars of Leptospira spp. in the state of Minas Gerais, Brazil, from 2008 to 2012. Braz J Microbiol. 2017;48:483–8.\nRomero EC, Blanco RM, Galloway RL. Analysis of multilocus sequence typing for identification of Leptospira isolates in Brazil. J Clin Microbiol. 2011;49:3940–2.\nMartins G, Penna B, Lilenbaum W. The dog in the transmission of human leptospirosis under tropical conditions: victim or villain? Epidemiol Infect. 2012;140:207–8.\nde Faria MT, Calderwood MS, Athanazio DA, McBride AJA, Hartskeerl RA, Pereira MM, Ko AI, Reis MG. Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil. Acta Trop. 2008;108:1–5.\nKo AI, Galvão Reis M, Ribeiro Dourado CM, Johnson WD, Riley LW. Urban epidemic of severe leptospirosis in Brazil. Lancet. 1999;354:820–5.\nRühl-Fehlert CI, Brem S, Feller W, Kopp H, Meyer P, Rinke M. Clinical, microbiological and pathological observations in laboratory beagle dogs infected with leptospires of the serogroup Sejroe. Exp Toxicol Pathol. 2000;52:201–7.\nBrod CS, Aleixo J, Jouglard SDD, Fernandes CPH, Teixeira JLR, Dellagostin OA. Evidence of dog as a reservoir for human leptospirosis: a serovar isolation, molecular characterization and its use in a serological survey. Rev Soc Bras Med Trop. 2005;38:294–300.\nda Silva Pinto P, Libonati H, Penna B, Lilenbaum W. A systematic review on the microscopic agglutination test seroepidemiology of bovine leptospirosis in Latin America. Trop Anim Health Prod. 2016;48:239–48.\nCerqueira GM, Picardeau M. A century of Leptospira strain typing. Infec Genet Evol. 2009;9:760–8.\nEllis WA. Control of canine leptospirosis in Europe: time for a change? Vet Rec. 2010;167:602–5.\nGautam R, Guptill LF, Wu CC, Potter A, Moore GE. Spatial and spatio-temporal clustering of overall and serovar-specific Leptospira microscopic agglutination test (MAT) seropositivity among dogs in the United States from 2000 through 2007. Prev Vet Med. 2010;96:122–31.",{"VOID":1893},"10.1186\u002Fs12917-018-1547-4","2024-06-22T23:39:36.794+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-018-1547-4",[1897,1914,1927,1940,1957,1970,1983,1996,2011],{"id":1898,"sortIndex":19,"researcher":18,"roles":1899,"affiliations":1900,"properties":1909,"displayName":1911,"givenName":18,"familyName":18},"bb5b42c4-2d7e-4276-a9d1-3f857205f371",[617],[1901],{"id":1902,"sortIndex":19,"affiliation":1903,"properties":18},"14093672-2875-4f14-af68-9dc54851392b",{"id":1902,"createTime":18,"updateTime":18,"relativeEntities":1904,"slug":18,"properties":1905,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1908,"statistic":18},[],{"title":1906},{"VI":1907},"Departamento de Clínica Médica (Department of Veterinary Clinics), Faculdade de Medicina Veterinária e Zootecnia (School of Veterinary Medicine and Animal Science), Universidade de São Paulo (University of São Paulo), São Paulo, Brazil",[],{"title":1910,"gsAuthor":1912},{"VI":1911},"Bruno Alonso Miotto",{"VOID":1913},"[\"F0Fur2YAAAAJ\"]",{"id":1915,"sortIndex":141,"researcher":18,"roles":1916,"affiliations":1917,"properties":1924,"displayName":1926,"givenName":18,"familyName":18},"bb44ab0d-c4a8-4d04-8e50-11f0cba2835f",[617],[1918],{"id":1902,"sortIndex":19,"affiliation":1919,"properties":18},{"id":1902,"createTime":18,"updateTime":18,"relativeEntities":1920,"slug":18,"properties":1921,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1923,"statistic":18},[],{"title":1922},{"VI":1907},[],{"title":1925},{"VI":1926},"Barbara Furlan Tozzi",{"id":1928,"sortIndex":233,"researcher":18,"roles":1929,"affiliations":1930,"properties":1937,"displayName":1939,"givenName":18,"familyName":18},"5b7460b2-ff48-41a5-89a7-b60c306948b0",[617],[1931],{"id":1902,"sortIndex":19,"affiliation":1932,"properties":18},{"id":1902,"createTime":18,"updateTime":18,"relativeEntities":1933,"slug":18,"properties":1934,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1936,"statistic":18},[],{"title":1935},{"VI":1907},[],{"title":1938},{"VI":1939},"Manoela de Souza Penteado",{"id":1941,"sortIndex":253,"researcher":18,"roles":1942,"affiliations":1943,"properties":1952,"displayName":1954,"givenName":18,"familyName":18},"4aaa3da9-b5f8-45b8-a1ca-ab286b89ab54",[617],[1944],{"id":1945,"sortIndex":19,"affiliation":1946,"properties":18},"5fc02edc-16e6-4f75-8c33-8391354312ce",{"id":1945,"createTime":18,"updateTime":18,"relativeEntities":1947,"slug":18,"properties":1948,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1951,"statistic":18},[],{"title":1949},{"VI":1950},"Departamento de Medicina Veterinária Preventiva e Saúde Animal (Department of Veterinary Preventive Medicine and Animal Health), Faculdade de Medicina Veterinária e Zootecnia (School of Veterinary Medicine and Animal Science), Universidade de São Paulo (University of São Paulo), São Paulo, Brazil",[],{"title":1953,"gsAuthor":1955},{"VI":1954},"Aline Gil Alves Guilloux",{"VOID":1956},"[\"qFTXZbkAAAAJ\"]",{"id":1958,"sortIndex":273,"researcher":18,"roles":1959,"affiliations":1960,"properties":1967,"displayName":1969,"givenName":18,"familyName":18},"4dca9c91-c1a2-4db4-9c46-3a5ee61dd5af",[617],[1961],{"id":1945,"sortIndex":19,"affiliation":1962,"properties":18},{"id":1945,"createTime":18,"updateTime":18,"relativeEntities":1963,"slug":18,"properties":1964,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1966,"statistic":18},[],{"title":1965},{"VI":1950},[],{"title":1968},{"VI":1969},"Luisa Zanolli Moreno",{"id":1971,"sortIndex":688,"researcher":18,"roles":1972,"affiliations":1973,"properties":1980,"displayName":1982,"givenName":18,"familyName":18},"239a023c-caaa-42fd-9174-4b625f40a12c",[617],[1974],{"id":1945,"sortIndex":19,"affiliation":1975,"properties":18},{"id":1945,"createTime":18,"updateTime":18,"relativeEntities":1976,"slug":18,"properties":1977,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1979,"statistic":18},[],{"title":1978},{"VI":1950},[],{"title":1981},{"VI":1982},"Marcos Bryan Heinemann",{"id":1984,"sortIndex":702,"researcher":18,"roles":1985,"affiliations":1986,"properties":1993,"displayName":1995,"givenName":18,"familyName":18},"22fe8d9f-462a-4a8a-910f-0ffba032912f",[617],[1987],{"id":1945,"sortIndex":19,"affiliation":1988,"properties":18},{"id":1945,"createTime":18,"updateTime":18,"relativeEntities":1989,"slug":18,"properties":1990,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1992,"statistic":18},[],{"title":1991},{"VI":1950},[],{"title":1994},{"VI":1995},"Andrea Micke Moreno",{"id":1997,"sortIndex":101,"researcher":18,"roles":1998,"affiliations":1999,"properties":2008,"displayName":2010,"givenName":18,"familyName":18},"d92d9f80-56e5-42a4-926b-a5eec37fc475",[617],[2000],{"id":2001,"sortIndex":19,"affiliation":2002,"properties":18},"14ef808f-4dfa-47c4-baf6-90731c105892",{"id":2001,"createTime":18,"updateTime":18,"relativeEntities":2003,"slug":18,"properties":2004,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2007,"statistic":18},[],{"title":2005},{"VI":2006},"Departamento de Microbiologia e Parasitologia (Department of Microbiology and Parasitology), Universidade Federal Fluminense, Niterói, Brazil",[],{"title":2009},{"VI":2010},"Walter Lilenbaum",{"id":2012,"sortIndex":729,"researcher":18,"roles":2013,"affiliations":2014,"properties":2021,"displayName":2023,"givenName":18,"familyName":18},"2c5fa6a9-d966-4401-aa0f-d99eb5aed8b1",[617],[2015],{"id":1902,"sortIndex":19,"affiliation":2016,"properties":18},{"id":1902,"createTime":18,"updateTime":18,"relativeEntities":2017,"slug":18,"properties":2018,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2020,"statistic":18},[],{"title":2019},{"VI":1907},[],{"title":2022},{"VI":2023},"Mitika Kuribayashi Hagiwara",{"url":18,"publisher":2025,"properties":18},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2026,"slug":10,"properties":2027,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":2030,"manageAffiliations":2039,"indexDatabases":2050,"url":18,"thumbnailPath":18,"statistic":2065,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":2028,"eissn":2029},{"EN":13},{"VOID":15},[2031,2035],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":2032,"label":2033,"description":2034,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":2036,"label":2037,"description":2038,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[2040,2045],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":2041,"slug":18,"properties":2042,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2044,"statistic":18},[],{"title":2043},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":2046,"slug":18,"properties":2047,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2049,"statistic":18},[],{"title":2048},{"EN":46},[],[2051,2058],{"id":50,"indexDatabase":2052,"url":61,"indexYears":62,"academicFieldIds":2057,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":2053,"label":2054,"description":2055,"key":58,"publicationTags":2056,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":2059,"url":81,"indexYears":18,"academicFieldIds":2064,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":2060,"label":2061,"description":2062,"key":77,"publicationTags":2063,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":2066,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":2067,"totalCitation":121,"totalCitationByYear":2068,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":2069,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"total":19,"publishYear":807,"statisticByYear":2071},{},"2018-07-17","2026-07-25T19:08:44.242+00:00",[66,79],{"id":2076,"createTime":2077,"updateTime":2078,"relativeEntities":2079,"slug":2080,"properties":2081,"entityType":185,"verifyStatus":186,"verifyTime":2092,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":2093,"fullTextUrl":18,"authors":2094,"publicationType":289,"publisherRelationship":2232,"citationCount":19,"citationInfo":2282,"publishDate":2285,"publishYear":2283,"citationAnalyzeStatus":1872,"lastCitationAnalyze":2286,"indexDatabases":2287,"openAccess":18,"references":18,"isForceReanalyzing":595},"82ca4644-5e97-4990-8112-e508504287d3","2023-12-31T06:46:51.205+00:00","2026-07-25T05:21:03.719+00:00",[],"Molecular-characterization-of-porcine-reproductive-and-respiratory-syndrome-virus-PRRSv-identified-from-slaughtered-pigs-in-northern-Uganda",{"abstract":2082,"title":2084,"gsPaper":2086,"references":2088,"doi":2090},{"EN":2083},"A cross sectional study was conducted to detect and characterize species of porcine reproductive and respiratory syndrome virus (PRRSv) identified from slaughtered pigs in Lira district, northern Uganda. The study was conducted from March to September 2019 in three selected slaughter slabs. Pigs brought for slaughter were randomly sampled. At necropsy, lungs were extracted from the thoracic cavity and examined for pneumonic lesions. Seventy-three (73) pigs with gross lung lesions were sampled, from which one hundred and one (101) tissue samples were taken. A real-time reverse transcriptase PCR (RT-qPCR) was used to characterize PRRSv species. A total of 20 samples tested positive for PRRSv. The respective prevalence of PRRSv type 1 and type 2 were 24.65% (n = 18) and 2.73% (n = 2) respectively. Of the pigs sampled (n = 73), only two pigs, 2.73% (n = 2) tested positive to both species. The likelihood of PRRSv detection decreased with pig age, but increased with gross pneumonic pathology. This study demonstrated dual circulation of both species in northern Uganda. The association between PRRSv and lung pathology suggests that it may be an important cause of lung disease in pigs in Uganda and hence loss of production. This calls for further investigations on potential economic impacts of PRRSv on pig productivity. These findings contribute to discussions about the need of surveillance and possible vaccination strategies against PRRSv in Uganda.",{"EN":2085},"Molecular characterization of porcine reproductive and respiratory syndrome virus (PRRSv) identified from slaughtered pigs in northern Uganda",{"VOID":2087},"[\"12341564864081370812\"]",{"VOID":2089},"UBOS. Statistical abstract [internet]. Entebbe; 2019. Available from: https:\u002F\u002Fwww.ubos.org\u002Fwp-content\u002Fuploads\u002Fpublications\u002F01_20202019_Statistical_Abstract_-Final.pdf\nOuma E, Ochieng J, Dione M, Pezo D. Governance structures in smallholder pig value chains in Uganda: constraints and opportunities for upgrading. Int Food Agribus Manag Rev. 2017;20:307–19.\nMuhanguzi D, Lutwama V, Mwiine FN. Factors that influence pig production in Central Uganda - case study of Nangabo Sub-County. Wakiso district Vet World. 2012;5:346–51.\nDione M, Masembe C, Akol J, Amia W, Kungu J, Lee HS, et al. The importance of on-farm biosecurity: Sero-prevalence and risk factors of bacterial and viral pathogens in smallholder pig systems in Uganda. Acta Trop. 2018;187:214–21.\nJonsson L. Emerging infectious diseases: using PCV2 as a model of disease transmission dynamics at the livestock-wildlife interface in Uganda; 2013.\nEneku W, Mutebi F, Mwiine F, Okwee-Acai J, Ojok L. Porcine Circovirus type 2 – systemic disease on pig farms and associated knowledge of key players in the pig industry in Central Uganda. Int J Vet Sci Med. 2018;6:178–85. Available from. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ijvsm.2018.08.004.\nNeumann E, Kliebenstein J, Johnson C, Mabry J, Bush E, Seitzinger A, et al. Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J Am Vet Med Assoc. 2005;227:385–92.\nZimmerman J, Benfield D, Murtaugh M, Osorio F, Stevenson G, Torremorell M. Porcine reproductive and respiratory syndrome virus (porcine arterivirus). In: Straw BE, Zimmerman JJ, D’Allaire S, Taylor DJ, editors. Dis swine. Ames: Iowa State University Press; 2006. p. 387–418.\nHoltkamp DJ, Kliebenstein JB, Neumann EJ, Zimmerman JJ, Rotto HF, Yoder TK, et al. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Heal Prod. 2013;21:72–84.\nWalker PJ, Siddell SG, Lefkowitz EJ, Mushegian AR, Adriaenssens EM, Dempsey DM, et al. Changes to virus taxonomy and the statutes ratified by the international committee on taxonomy of viruses (2020). Arch Virol. 2020;165:2737–48. Available from. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00705-020-04752-x.\nKuhn J, Lauck M, Bailey A, Shchetinin A, Vishnevskaya T, Bao Y, et al. Reorganization and expansion of the nidoviral family Arteriviridae. Arch Virol. 2016;161:755–68.\nMeng X. Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Vet Microbiol. 2000;74:309–29.\nKapur V, Elam M, Pawlovich T, Murtaugh M. Genetic variation in porcine reproductive and respiratory syndrome virus isolates in the midwestern United States. J Gen Virol. 1996;77:1271–6.\nOsorio F, Galeota J, Nelson E, Brodersen B, Doster A, Wills R, et al. Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity. Virology. 2002;302:9–20.\nNieuwenhuis N, Duinhof T, van Nes A. Economic analysis of outbreaks of porcine reproductive and respiratory syndrome virus in nine sow herds. Vet Record. 2012;170(9). https:\u002F\u002Fdoi.org\u002F10.1136\u002Fvr.100101.\nOIE. Porcine reproductive and respiratory syndrome in South Africa. Follow-up report no. 2. Disease information (weekly info), 2006, vol. 19; 2005. p. 38.\nRenukaradhya G, Meng X, Calvert J, Roof M, KM. L. Live porcine reproductive and respiratory syndrome virus vaccines: current status and future direction. Vaccine. 2015;33:4069–80.\nMurtaugh M, Genzow M. Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS). Vaccine. 2011;29:8192–204.\nOba P, Dione MM, Wieland B, Mwiine F, Erume J. Correlations between lung pneumonic lesions and serologic status for key respiratory pathogens in slaughtered pigs in northern Uganda. Porcine Health Manag. 2021;7(1):1–10. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs40813-021-00233-y.\nDohoo I, Martin W, Stryhn H. Veterinary epidemiologic research. 2nd. Charllotetown: AVC Inc; 2003.\nPallarés F, Añón J, Rodríguez-Gómez I, Gómez-Laguna J, Fabré R, Sánchez-Carvajal J, et al. Prevalence of mycoplasma-like lung lesions in pigs from commercial farms from Spain and Portugal. Porcine Health Manag. 2021;7:1–8.\nKleiboeker SB, Schommer SK, Lee SM, Watkins S, Chittick W, Polson D. Simultaneous detection of north American and European porcine reproductive and respiratory syndrome virus using real-time quantitative reverse transcriptase-PCR. J Vet Diagnostic Investig. 2005;17:165–70.\nAtherstone C, Galiwango RG, Grace D, Alonso S, Dhand NK, Ward MP, et al. Analysis of pig trading networks and practices in Uganda. Trop Anim Health Prod. 2019;51:137–47.\nShibata I, Moriy M, Yazawa S. Experimental reinfection with homologous porcine reproductive and respiratory syndrome virus in SPF pigs. J Vet Med Sci. 2000;62:105–8.\nKlinge K, Vaughn E, Roof M, Bautista E, Murtaugh M. Age-dependent resistance to porcine reproductive and respiratory syndrome virus replication in swine. Virology. 2009;6:177.\nWills RW, Doster AR, Galeota JA, Jung-Hyang S, Osorio FA. Duration of Infection and Proportion of Pigs Persistently Infected with Porcine Reproductive and Respiratory Syndrome Virus. J Clin Microbiol. 2003;41:58–62.\nNathues H, Alarcon P, Rushton J, Jolie R, Fiebig K, Jimenez M, et al. Cost of porcine reproductive and respiratory syndrome virus at individual farm level – an economic disease model. Prev Vet Med. 2017;142:16–29.\nEvans C, Medley G, Creasey S, Green L. A stochastic mathematical model of the within-herd transmission dynamics of porcine reproductive and respiratory syndrome virus (PRRSV): fade-out and persistence. Prev Vet Med. 2010;93:248–57.\nThacker E, Halbur P, Ross R, Thanawongnuwech R, Thacker B. Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia. J Clin Microbiol. 1999;37:620–7.\nStadejek T, Larsen L, Podgórska K, Bøtner A, Botti S, Dolka I, et al. Pathogenicity of three genetically diverse strains of PRRSV type 1 in specific pathogen free pigs. Vet Microbiol. 2017;209:13–9.\nWang X, Yang X, Zhou R, Zhou L, Ge X, Guo X, et al. Genomic characterization and pathogenicity of a strain of type 1 porcine reproductive and respiratory syndrome virus. Virus Res. 225:40–9.\nKang H, Yu JE, Shin JE, Kang A, Kim W Il, Lee C, et al. Geographic distribution and molecular analysis of porcine reproductive and respiratory syndrome viruses circulating in swine farms in the Republic of Korea between 2013 and 2016. BMC Vet Res. 2018;14:1–11.\nAiki-Raji CO, Adebiyi AI, Abiola JO, Oluwayelu DO. Prevalence of porcine reproductive and respiratory syndrome virus and porcine parvovirus antibodies in commercial pigs, southwest Nigeria. Beni-Suef Univ J Basic Appl Sci [Internet]. Beni-Suef University; 2017; Available from: http:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS2314853517301695\nOosthuizen C. A restrospective study of a Porcine Reproductive and Respiratory Syndrome outbreak in South Africa in 2004. Prod Anim Stud [Internet]. 2010;MMedVet:42. Available from: http:\u002F\u002Fupetd.up.ac.za\u002Fthesis\u002Favailable\u002Fetd-06102011-155507\u002F\nLurchachaiwong W, Payungporn S, Srisatidnarakul U, Mungkundar C, Theamboonlers A, Poovorawan Y. Rapid detection and strain identification of porcine reproductive and respiratory syndrome virus (PRRSV) by real-time RT-PCR. Lett Appl Microbiol. 2008;46:55–60.",{"VOID":2091},"10.1186\u002Fs12917-022-03272-x","2024-06-24T06:35:59.112+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-022-03272-x",[2095,2119,2136,2153,2178,2193,2206,2219],{"id":2096,"sortIndex":19,"researcher":18,"roles":2097,"affiliations":2098,"properties":2116,"displayName":2118,"givenName":18,"familyName":18},"ea9fcb0c-251d-4b58-8173-5ed0e996c4ae",[617],[2099,2107],{"id":2100,"sortIndex":19,"affiliation":2101,"properties":18},"4c8e09ad-20ea-4eff-8b47-6b488307990d",{"id":2100,"createTime":18,"updateTime":18,"relativeEntities":2102,"slug":18,"properties":2103,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2106,"statistic":18},[],{"title":2104},{"VI":2105},"International Livestock Research Institute, Kampala, Uganda",[],{"id":2108,"sortIndex":141,"affiliation":2109,"properties":2115},"6df362fd-5fc6-4d20-98e3-6bdf6232e758",{"id":2108,"createTime":18,"updateTime":18,"relativeEntities":2110,"slug":18,"properties":2111,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2114,"statistic":18},[],{"title":2112},{"VI":2113},"National Agricultural Research Organization, Abi Zonal Agricultural Research and Development Institute (Abi ZARDI), Arua, Uganda",[],{},{"title":2117},{"VI":2118},"Peter Oba",{"id":2120,"sortIndex":141,"researcher":18,"roles":2121,"affiliations":2122,"properties":2131,"displayName":2133,"givenName":18,"familyName":18},"3de09ccf-b641-489d-936c-5284f634c9c5",[617],[2123],{"id":2124,"sortIndex":19,"affiliation":2125,"properties":18},"2d60c1a5-2d34-409c-bfc3-113b8f18c825",{"id":2124,"createTime":18,"updateTime":18,"relativeEntities":2126,"slug":18,"properties":2127,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2130,"statistic":18},[],{"title":2128},{"VI":2129},"International Livestock Research Institute, c\u002Fo AfricaRice, Dakar, Senegal",[],{"title":2132,"gsAuthor":2134},{"VI":2133},"Michel M. Dione",{"VOID":2135},"[\"s6c-Jb4AAAAJ\"]",{"id":2137,"sortIndex":233,"researcher":18,"roles":2138,"affiliations":2139,"properties":2148,"displayName":2150,"givenName":18,"familyName":18},"1654f473-40e6-4cfc-a1bd-e3afd684c5d3",[617],[2140],{"id":2141,"sortIndex":19,"affiliation":2142,"properties":18},"993214cb-d704-48a3-b86f-fa1fe4022f6a",{"id":2141,"createTime":18,"updateTime":18,"relativeEntities":2143,"slug":18,"properties":2144,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2147,"statistic":18},[],{"title":2145},{"VI":2146},"College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda",[],{"title":2149,"gsAuthor":2151},{"VI":2150},"Joseph Erume",{"VOID":2152},"[\"pKD6U-UAAAAJ\"]",{"id":2154,"sortIndex":253,"researcher":18,"roles":2155,"affiliations":2156,"properties":2173,"displayName":2175,"givenName":18,"familyName":18},"46fb5c56-6478-48b0-b686-e05138ab5844",[617],[2157,2165],{"id":2158,"sortIndex":19,"affiliation":2159,"properties":18},"ce785dd8-81d8-42d2-bc3f-6cd024cba52c",{"id":2158,"createTime":18,"updateTime":18,"relativeEntities":2160,"slug":18,"properties":2161,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2164,"statistic":18},[],{"title":2162},{"VI":2163},"Institute of Virology and Immunology (IVI), Mittelhaeusern, Switzerland",[],{"id":2166,"sortIndex":141,"affiliation":2167,"properties":18},"f8b2aaa9-f2cf-4a9c-a0b2-41668a334524",{"id":2166,"createTime":18,"updateTime":18,"relativeEntities":2168,"slug":18,"properties":2169,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2172,"statistic":18},[],{"title":2170},{"VI":2171},"Department of Infectious Diseases and Pathobiology (DIP), Vetsuisse Faculty, University of Bern, Bern, Switzerland",[],{"title":2174,"gsAuthor":2176},{"VI":2175},"Barbara Wieland",{"VOID":2177},"[\"6jx5KMsAAAAJ\"]",{"id":2179,"sortIndex":273,"researcher":18,"roles":2180,"affiliations":2181,"properties":2190,"displayName":2192,"givenName":18,"familyName":18},"c168193a-735b-468a-874d-ee82779bd3b3",[617],[2182],{"id":2183,"sortIndex":19,"affiliation":2184,"properties":18},"441a5bfe-2a45-43a5-8156-0dcbc86a76df",{"id":2183,"createTime":18,"updateTime":18,"relativeEntities":2185,"slug":18,"properties":2186,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2189,"statistic":18},[],{"title":2187},{"VI":2188},"International Livestock Research Institute, Nairobi, Kenya",[],{"title":2191},{"VI":2192},"Christine Mutisya",{"id":2194,"sortIndex":688,"researcher":18,"roles":2195,"affiliations":2196,"properties":2203,"displayName":2205,"givenName":18,"familyName":18},"1ed2a169-ac75-43cd-a0f0-0a817a8ee4ee",[617],[2197],{"id":2183,"sortIndex":19,"affiliation":2198,"properties":18},{"id":2183,"createTime":18,"updateTime":18,"relativeEntities":2199,"slug":18,"properties":2200,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2202,"statistic":18},[],{"title":2201},{"VI":2188},[],{"title":2204},{"VI":2205},"Linnet Ochieng",{"id":2207,"sortIndex":702,"researcher":18,"roles":2208,"affiliations":2209,"properties":2216,"displayName":2218,"givenName":18,"familyName":18},"02a1a1da-de94-41f1-bbe3-782924d28e70",[617],[2210],{"id":2183,"sortIndex":19,"affiliation":2211,"properties":18},{"id":2183,"createTime":18,"updateTime":18,"relativeEntities":2212,"slug":18,"properties":2213,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2215,"statistic":18},[],{"title":2214},{"VI":2188},[],{"title":2217},{"VI":2218},"Elizabeth A. J. Cook",{"id":2220,"sortIndex":101,"researcher":18,"roles":2221,"affiliations":2222,"properties":2229,"displayName":2231,"givenName":18,"familyName":18},"e94f1e8e-859c-4191-9970-c41836b16236",[617],[2223],{"id":2141,"sortIndex":19,"affiliation":2224,"properties":18},{"id":2141,"createTime":18,"updateTime":18,"relativeEntities":2225,"slug":18,"properties":2226,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2228,"statistic":18},[],{"title":2227},{"VI":2146},[],{"title":2230},{"VI":2231},"Frank N. Mwiine",{"url":2093,"publisher":2233,"properties":2278},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2234,"slug":10,"properties":2235,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":2238,"manageAffiliations":2247,"indexDatabases":2258,"url":18,"thumbnailPath":18,"statistic":2273,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":2236,"eissn":2237},{"EN":13},{"VOID":15},[2239,2243],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":2240,"label":2241,"description":2242,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":2244,"label":2245,"description":2246,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[2248,2253],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":2249,"slug":18,"properties":2250,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2252,"statistic":18},[],{"title":2251},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":2254,"slug":18,"properties":2255,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2257,"statistic":18},[],{"title":2256},{"EN":46},[],[2259,2266],{"id":50,"indexDatabase":2260,"url":61,"indexYears":62,"academicFieldIds":2265,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":2261,"label":2262,"description":2263,"key":58,"publicationTags":2264,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":2267,"url":81,"indexYears":18,"academicFieldIds":2272,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":2268,"label":2269,"description":2270,"key":77,"publicationTags":2271,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":2274,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":2275,"totalCitation":121,"totalCitationByYear":2276,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":2277,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"pages":2279,"volume":2280},{"VOID":1461},{"VOID":2281},"18",{"total":19,"publishYear":2283,"statisticByYear":2284},2022,{},"2022-05-13","2026-07-25T05:21:03.718+00:00",[66,79],{"id":2289,"createTime":2290,"updateTime":2291,"relativeEntities":2292,"slug":2293,"properties":2294,"entityType":185,"verifyStatus":186,"verifyTime":2305,"verifyNote":188,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":2306,"fullTextUrl":18,"authors":2307,"publicationType":289,"publisherRelationship":2366,"citationCount":18,"citationInfo":18,"publishDate":2416,"publishYear":1653,"citationAnalyzeStatus":2417,"lastCitationAnalyze":2418,"indexDatabases":2419,"openAccess":18,"references":18,"isForceReanalyzing":595},"ca5a941c-011c-4a9c-8165-482cef6314c5","2024-01-11T05:49:02.037+00:00","2026-07-23T16:48:45.371+00:00",[],"Verifying-the-placement-and-length-of-feeding-tubes-in-canine-and-feline-neonates",{"abstract":2295,"title":2297,"gsPaper":2299,"references":2301,"doi":2303},{"EN":2296},"Tube feeding is a common procedure in neonatology. In humans, tube misplacement reportedly occurs in up to 59% of all cases and may lead to perforation in 1.1% of preterm intubated neonates. While numerous studies on optimal tube placement have been performed in human neonates, current recommendations on tube feeding in canine and feline neonatology are based, at best, on studies performed in adult animals. Herein, we aimed to test ultrasonography as a tool to verify tube placement in puppies and kittens and to compare different anatomical predictive markers used in human, canine and feline neonates. The predictive tube length when held bent between the last rib and the mouth may induce trauma compared to when held straight. A strong positive linear correlation was observed between birthweight and gastric cardia localization. Ultrasonography findings were similar to coeliotomy findings. Stomach volume was less than 2 mL per 100 g in the less-than-one-day-old studied puppies (n = 25) and kittens (n = 28). A weight-based equation was calculated to help predict appropriate tube placement. Ultrasonography can be used to control gastric tube placement, and neonates less than one-day-old have a smaller stomach capacity. Further studies are required to evaluate whether more-than-one-day-old puppies follow the same linear correlation with their weight. Further in vivo studies are warranted to determine the gold standard procedure for tube feeding in neonatal puppies and kittens.",{"EN":2298},"Verifying the placement and length of feeding tubes in canine and feline neonates",{"VOID":2300},"[]",{"VOID":2302},"Lawler DF. Neonatal and pediatric care of the puppy and kitten. Theriogenology. 2008;70(3):384–92. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.theriogenology.2008.04.019.\nMunnich A, Kuchenmeister U. Causes, diagnosis and therapy of common diseases in neonatal puppies in the first days of life: cornerstones of practical approach. Reprod Domest Anim. 2014;49(Suppl 2):64–74. https:\u002F\u002Fdoi.org\u002F10.1111\u002Frda.12329.\nBoothe DM, Bucheler J. Drug and blood component therapy and neonatal isoreythrolysis. In: Hoskins JD, editor. Veterinary pediatrics: dogs and cats from birth to six months. Philadelphia: WB Saunders; 2001. p. 35–56.\nJohnston SD, Root Kustritz MV, Olson PNS. The neonate - from birth to weaning. In: Johnson JA, Root Kustritz MV, Olson PNS, editors. Canine and Feline theriogenology; 2010. p. 162–3.\nRoot Kustritz MV. How are orphan puppies and kittens best fed? Clinical canine and feline reproduction, evidence-based answers. Hoboken: Wiley; 2010. p. 285–7.\nLawler DF, Chandler ML. Indications and techniques for tube-feeding puppies. Canine Pract. 1992;17(1):20–3.\nFontbonne A, Levy X, Fontaine E, Gilson C. Intubation gastrique du nouveau-né. Guide pratique de reproduction clinique canine et féline. Paris: Medcom ed.; 2007. p. 212–3.\nBaines FM. Milk substitutes and the hand rearing of orphan puppies and kittens. J Small Anim Pract. 1981;22(9):555–78. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1748-5827.1981.tb01413.x.\nOwens L, Burrin DG, Berseth CL. Minimal enteral feeding induces maturation of intestinal motor function but not mucosal growth in neonatal dogs. J Nutr. 2002;132(9):2717–22. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjn\u002F132.9.2717.\nSchwarz SM, Heird WC. Effects of feeding on the small intestinal mucosa of beagle pups during the first 5 d of life. Am J Clin Nutr. 1994;60(6):879–86. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fajcn\u002F60.6.879.\nCasal M. Management and critical care of the neonate. In: England G, Von Heimendahl A, editors. BSAVA manual of canine and feline reproduction and neonatology. 2nd. ed. Gloucester: British Small Animal Veterinary Association; 2010. p. 135–46. https:\u002F\u002Fdoi.org\u002F10.22233\u002F9781905319541.15.\nChastant S, Mila H. Passive immune transfer in puppies. Anim Reprod Sci. 2019;207:162–70. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.anireprosci.2019.06.012.\nGill MA. Perinatal and late neonatal mortality in the dog [PhD]. University of Sidney; 2001. https:\u002F\u002Fcore.ac.uk\u002Fdownload\u002Fpdf\u002F41232423.pdf.\nMosier JE. The puppy from birth to six weeks. Vet Clin North Am. 1978;8(1):79–100. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0091-0279(78)50006-3.\nSheffy BE. Nutrition and nutritional disorders. Vet Clin North Am. 1978;8(1):7–29. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0091-0279(78)50003-8.\nPrendergast H. Care of the orphaned puppy and kitten. In: Peterson ME, Kutzler MA, editors. Small animal pediatrics; 2011. p. 67–72.\nMoxon R, England G. Care of puppies during the neonatal period: part 2 care of the sick neonate. Vet Nurs J. 2012;27:61–5.\nEllett ML, Cohen MD, Perkins SM, Croffie JM, Lane KA, Austin JK. Comparing methods of determining insertion length for placing gastric tubes in children 1 month to 17 years of age. J Spec Pediatr Nurs. 2012;17(1):19–32. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1744-6155.2011.00302.x.\nQuandt D, Schraner T, Ulrich Bucher H, Arlettaz MR. Malposition of feeding tubes in neonates: is it an issue? J Pediatr Gastroenterol Nutr. 2009;48(5):608–11. https:\u002F\u002Fdoi.org\u002F10.1097\u002FMPG.0b013e31818c52a8.\nThanhaeuser M, Lindtner-Kreindler C, Berger A, Haiden N. Conservative treatment of iatrogenic perforations caused by gastric tubes in extremely low birth weight infants. Early Hum Dev. 2019;137:104836. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.earlhumdev.2019.104836.\nLittle S. Playing mum: successful management of orphaned kittens. J Feline Med Surg. 2013;15(3):201–10. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1098612X13477542.\nMacintire DK. Pediatric fluid therapy. Vet Clin North Am Small Anim Pract. 2008;38(3):621–7, xii. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cvsm.2008.01.004.\nHoskins JD. Nutrition and nutritional problems. Veterinary Pediatrics, dogs and cats from birth to six months. 3rd ed; 2001. p. 476–89.\nMacintire DK. Intensive care management. In: Hoskins JD, editor. Veterinary Pediatrics: dogs and cats from birth to six months. Philadelphia: WB Saunders; 2001. p. 62–73.\nPierson P, Grandjean D, Sergheraert R, Pibot P. Guide Pratique de l'élevage canin. 7th edition ed. Rivière S, editor. Aimargues: Royal Canin SAS; 2018.\nHan E. Esophageal and gastric feeding tubes in ICU patients. Clin Tech Small Anim Pract. 2004;19(1):22–31. https:\u002F\u002Fdoi.org\u002F10.1053\u002FS1096-2867(03)00080-X.\nArmstrong PJ, Hand MS, Frederick GS. Enteral nutrition by tube. Vet Clin N Am-Small. 1990;20(1):237–75. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0195-5616(90)50024-8.\nChan DL. The Inappetent hospitalised cat: clinical approach to maximising nutritional support. J Feline Med Surg. 2009;11(11):925–33. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jfms.2009.09.013.\nYu MK, Freeman LM, Heinze CR, Parker VJ, Linder DE. Comparison of complication rates in dogs with nasoesophageal versus nasogastric feeding tubes. J Vet Emerg Crit Care (San Antonio). 2013;23(3):300–4. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fvec.12048.\nJolliet P, Pichard C, Biolo G, Chiolero R, Grimble G, Leverve X, et al. Enteral nutrition in intensive care patients: a practical approach. Clin Nutr. 1999;18(1):47–56. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0261-5614(99)80049-1.\nAbood SK, Buffington CA. Enteral feeding of dogs and cats: 51 cases (1989-1991). J Am Vet Med Assoc. 1992;201(4):619–22.\nIrving SY, Rempel G, Lyman B, Sevilla WMA, Northington L, Guenter P, et al. Pediatric nasogastric tube placement and verification: best practice recommendations from the NOVEL project. Nutr Clin Pract. 2018;33(6):921–7. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fncp.10189.\nIrving SY, Lyman B, Northington L, Bartlett JA, Kemper C, Group NPW. Nasogastric tube placement and verification in children: review of the current literature. Nutr Clin Pract. 2014;29(3):267–76. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0884533614531456.\nRoubenoff R, Ravich WJ. Pneumothorax due to nasogastric feeding tubes. Report of four cases, review of the literature, and recommendations for prevention. Arch Intern Med. 1989;149(1):184–8. https:\u002F\u002Fdoi.org\u002F10.1001\u002Farchinte.1989.00390010156022.\nFarrington M, Lang S, Cullen L, Stewart S. Nasogastric tube placement verification in pediatric and neonatal patients. Pediatr Nurs. 2009;35(1):17–24.\nBeckstrand J, Cirgin Ellett ML, McDaniel A. Predicting internal distance to the stomach for positioning nasogastric and orogastric feeding tubes in children. J Adv Nurs. 2007;59(3):274–89. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1365-2648.2007.04296.x.\nEllett ML. Important facts about intestinal feeding tube placement. Gastroenterol Nurs. 2006;29(2):112–24; quiz 24-5. https:\u002F\u002Fdoi.org\u002F10.1097\u002F00001610-200603000-00004.\nSociety of Pediatric Nurses Clinical Practice C, Committee SPNR, Longo MA. Best evidence: nasogastric tube placement verification. J Pediatr Nurs. 2011;26(4):373–6. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.pedn.2011.04.030.\nNguyen S, Fang A, Saxton V, Holberton J. Accuracy of a weight-based formula for neonatal gastric tube insertion length. Adv Neonatal Care. 2016;16(2):158–61. https:\u002F\u002Fdoi.org\u002F10.1097\u002FANC.0000000000000261.\nFreeman D, Saxton V, Holberton J. A weight-based formula for the estimation of gastric tube insertion length in newborns. Adv Neonatal Care. 2012;12(3):179–82. https:\u002F\u002Fdoi.org\u002F10.1097\u002FANC.0b013e318256bb13.\nAtalay YO, Aydin R, Ertugrul O, Gul SB, Polat AV, Paksu MS. Does bedside sonography effectively identify nasogastric tube placements in pediatric critical care patients? Nutr Clin Pract. 2016;31(6):805–9. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0884533616639401.\nAtalay YO, Polat AV, Ozkan EO, Tomak L, Aygun C, Tobias JD. Bedside ultrasonography for the confirmation of gastric tube placement in the neonate. Saudi J Anaesth. 2019;13(1):23–7. https:\u002F\u002Fdoi.org\u002F10.4103\u002Fsja.SJA_413_18.\nEllett ML, Croffie JM, Cohen MD, Perkins SM. Gastric tube placement in young children. Clin Nurs Res. 2005;14(3):238–52. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1054773805275121.\nGilbert RT, Burns SM. Increasing the safety of blind gastric tube placement in pediatric patients: the design and testing of a procedure using a carbon dioxide detection device. J Pediatr Nurs. 2012;27(5):528–32. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.pedn.2011.08.004.\nKhair J. Guidelines for testing the placing of nasogastric tubes. Nurs Times. 2005;101(20):26–7.\nRoot Kustritz MV. History and physical examination of the neonate. Small animal pediatrics: the first 12 months of life. St. Louis: Saunders Elsevier; 2011. p. 21.\nSeim HB. Feeding tube placement. Rhodes: World Small Animal Veterinary Association World Congress WSAVA 2004 Congress online proceedings; 2004. https:\u002F\u002Fwww.vin.com\u002Fapputil\u002Fcontent\u002Fdefaultadv1.aspx?pId=11181&catId=30097&id=3852319\nOmari TI, Miki K, Davidson G, Fraser R, Haslam R, Goldsworthy W, et al. Characterisation of relaxation of the lower oesophageal sphincter in healthy premature infants. Gut. 1997;40(3):370–5. https:\u002F\u002Fdoi.org\u002F10.1136\u002Fgut.40.3.370.\nRayyan M, Omari T, Debeer A, Allegaert K, Rommel N. Characterization of esophageal motility and esophagogastric junction in preterm infants with bronchopulmonary dysplasia. Neurogastroenterol Motil. 2020;32(7):e13849. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fnmo.13849.\nSpedale SB, Weisbrodt NW, Morriss FH Jr. Ontogenic studies of gastrointestinal function. II. Lower esophageal sphincter maturation in neonatal beagle puppies. Pediatr Res. 1982;16(10):851–5. https:\u002F\u002Fdoi.org\u002F10.1203\u002F00006450-198210000-00010.\nChastant-Maillard S, Freyburger L, Marcheteau E, Thoumire S, Ravier JF, Reynaud K. Timing of the intestinal barrier closure in puppies. Reprod Domest Anim. 2012;47(Suppl 6):190–3. https:\u002F\u002Fdoi.org\u002F10.1111\u002Frda.12008.\nAndersen AC. Digestive system. In: Andersen AC, editor. The Beagle as an experimental dog; 1970. p. 226–31.\nRoos J, Maenhoudt C, Zilberstein L, Mir F, Borges P, Furthner E, et al. Neonatal puppy survival after planned caesarean section in the bitch using aglepristone as a primer: a retrospective study on 74 cases. Reprod Domest Anim. 2018;53(Suppl 3):85–95. https:\u002F\u002Fdoi.org\u002F10.1111\u002Frda.13353.\nCirgin Ellett ML, Cohen MD, Perkins SM, Smith CE, Lane KA, Austin JK. Predicting the insertion length for gastric tube placement in neonates. J Obstet Gynecol Neonatal Nurs. 2011;40(4):412–21. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1552-6909.2011.01255.x.\nvan Wijk MP, Benninga MA, Dent J, Lontis R, Goodchild L, McCall LM, et al. Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonate. J Pediatr. 2007;151(6):585–90, 90 e1–2.\nKirk CA. New concepts in pediatric nutrition. Vet Clin North Am Small Anim Pract. 2001;31(2):369–92. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0195-5616(01)50210-7.\nOswald H, Sharkey M, Pade D, Martinez MN. Canine gastrointestinal physiology: Breeds variations that can influence drug absorption. Eur J Pharm Biopharm. 2015;97(Pt A):192–203.",{"VOID":2304},"10.1186\u002Fs12917-021-02909-7","2024-08-30T14:12:04.850+00:00","https:\u002F\u002Fbmcvetres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12917-021-02909-7",[2308,2323,2338,2353],{"id":2309,"sortIndex":19,"researcher":18,"roles":2310,"affiliations":2311,"properties":2320,"displayName":2322,"givenName":18,"familyName":18},"d8d27ce0-eb8d-4272-b46e-b748314e65ab",[617],[2312],{"id":2313,"sortIndex":19,"affiliation":2314,"properties":18},"3dced24d-d834-4ffc-a9c6-4b034aa0ea7b",{"id":2313,"createTime":18,"updateTime":18,"relativeEntities":2315,"slug":18,"properties":2316,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2319,"statistic":18},[],{"title":2317},{"VI":2318},"Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland",[],{"title":2321},{"VI":2322},"Etienne Furthner",{"id":2324,"sortIndex":141,"researcher":18,"roles":2325,"affiliations":2326,"properties":2335,"displayName":2337,"givenName":18,"familyName":18},"6f99b13a-66f1-48a5-a3d7-cd5a81743957",[617],[2327],{"id":2328,"sortIndex":19,"affiliation":2329,"properties":18},"dcc0c42c-a976-41a5-8754-300ae9f2a000",{"id":2328,"createTime":18,"updateTime":18,"relativeEntities":2330,"slug":18,"properties":2331,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2334,"statistic":18},[],{"title":2332},{"VI":2333},"Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland",[],{"title":2336},{"VI":2337},"Mariusz Paweł Kowalewski",{"id":2339,"sortIndex":233,"researcher":18,"roles":2340,"affiliations":2341,"properties":2350,"displayName":2352,"givenName":18,"familyName":18},"e97c6c57-1933-4825-befc-76086416a4cb",[617],[2342],{"id":2343,"sortIndex":19,"affiliation":2344,"properties":18},"d50f2629-a2eb-43a4-87ba-58784aa7b619",{"id":2343,"createTime":18,"updateTime":18,"relativeEntities":2345,"slug":18,"properties":2346,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2349,"statistic":18},[],{"title":2347},{"VI":2348},"Institute of Veterinary Epidemiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland",[],{"title":2351},{"VI":2352},"Paul Torgerson",{"id":2354,"sortIndex":253,"researcher":18,"roles":2355,"affiliations":2356,"properties":2363,"displayName":2365,"givenName":18,"familyName":18},"11b4755f-13cd-402f-ae1d-63deac5868b8",[617],[2357],{"id":2313,"sortIndex":19,"affiliation":2358,"properties":18},{"id":2313,"createTime":18,"updateTime":18,"relativeEntities":2359,"slug":18,"properties":2360,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2362,"statistic":18},[],{"title":2361},{"VI":2318},[],{"title":2364},{"VI":2365},"Iris Margaret Reichler",{"url":2306,"publisher":2367,"properties":2412},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2368,"slug":10,"properties":2369,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":2372,"manageAffiliations":2381,"indexDatabases":2392,"url":18,"thumbnailPath":18,"statistic":2407,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"title":2370,"eissn":2371},{"EN":13},{"VOID":15},[2373,2377],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":2374,"label":2375,"description":2376,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{},{"id":28,"createTime":18,"updateTime":18,"relativeEntities":2378,"label":2379,"description":2380,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":31},{},[2382,2387],{"id":35,"createTime":18,"updateTime":18,"relativeEntities":2383,"slug":18,"properties":2384,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2386,"statistic":18},[],{"title":2385},{"EN":39},[],{"id":42,"createTime":18,"updateTime":18,"relativeEntities":2388,"slug":18,"properties":2389,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2391,"statistic":18},[],{"title":2390},{"EN":46},[],[2393,2400],{"id":50,"indexDatabase":2394,"url":61,"indexYears":62,"academicFieldIds":2399,"indexDatabaseRanking":66},{"id":52,"createTime":18,"updateTime":18,"relativeEntities":2395,"label":2396,"description":2397,"key":58,"publicationTags":2398,"standard":18},[],{"EN":55,"VI":55},{"EN":55,"VI":57},[60],[64,65],{"id":68,"indexDatabase":2401,"url":81,"indexYears":18,"academicFieldIds":2406,"indexDatabaseRanking":18},{"id":70,"createTime":18,"updateTime":18,"relativeEntities":2402,"label":2403,"description":2404,"key":77,"publicationTags":2405,"standard":18},[],{"EN":73,"VI":73},{"EN":75,"VI":76},[79,80],[83],{"impactFactor":19,"impactFactorByYear":2408,"i10Index":97,"i10IndexLast5Year":98,"totalPublication":99,"totalPublicationByYear":2409,"totalCitation":121,"totalCitationByYear":2410,"totalCitationPerPublication":142,"totalCitationPerPublicationByYear":2411,"hindexLast5Year":162,"hindex":162},{"2011":86,"2012":87,"2013":88,"2014":89,"2015":90,"2016":91,"2017":92,"2018":88,"2019":93,"2020":94,"2021":95,"2022":96,"2023":89},{"2005":101,"2006":102,"2007":103,"2008":104,"2009":105,"2010":106,"2011":107,"2012":108,"2013":109,"2014":110,"2015":111,"2016":112,"2017":113,"2018":114,"2019":115,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120},{"2005":123,"2006":124,"2007":125,"2008":126,"2009":127,"2010":128,"2011":129,"2012":130,"2013":131,"2014":132,"2015":133,"2016":134,"2017":135,"2018":136,"2019":137,"2020":138,"2021":139,"2022":140,"2023":141},{"2005":144,"2006":145,"2007":146,"2008":147,"2009":148,"2010":149,"2011":150,"2012":151,"2013":152,"2014":153,"2015":154,"2016":151,"2017":155,"2018":156,"2019":157,"2020":158,"2021":159,"2022":160,"2023":161},{"pages":2413,"volume":2415},{"VOID":2414},"1-12",{"VOID":1650},"2021-06-07","ERROR_IN_GET_PLATFORM_ID","2026-07-23T16:48:45.370+00:00",[66,79]]