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Fifty years of research in ARDS. The epidemiology of acute respiratory distress syndrome. A 50th birthday review. Am J Respir Crit Care Med. 2017;195(7):860–70.\nKao KC, Hu HC, Hsieh MJ, Tsai YH, Huang CC. Comparison of community-acquired, hospital-acquired, and intensive care unit-acquired acute respiratory distress syndrome: a prospective observational cohort study. Crit Care. 2015;19:384.\nSligl WI, Marrie TJ. Severe community-acquired pneumonia. Crit Care Clin. 2013;29(3):563–601.\nMusher DM, Thorner AR. Community-acquired pneumonia. N Engl J Med. 2014;371(17):1619–28.\nBellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016 Feb;315(8):788–800.\nMandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America\u002FAmerican Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27–72.\nMikasa K, Aoki N, Aoki Y, Abe S, Iwata S, Ouchi K, et al. JAID\u002FJSC guidelines for the treatment of respiratory infectious diseases: the Japanese Association for Infectious Diseases\u002FJapanese Society of Chemotherapy guide to clinical management of infectious disease\u002Fguideline-preparing committee respiratory infectious disease WG. J Infect Chemother. 2016;22(7 Suppl):S1–65.\nCorrales-Medina VF, Musher DM. Immunomodulatory agents in the treatment of community-acquired pneumonia: a systematic review. J Inf Secur. 2011;63(3):187–99.\nSligl WI, Asadi L, Eurich DT, Tjosvold L, Marrie TJ, Majumdar SR. Macrolides and mortality in critically ill patients with community-acquired pneumonia: a systematic review and meta-analysis. Crit Care Med. 2014;42(2):420–32.\nKawamura K, Ichikado K, Takaki M, Sakata Y, Yasuda Y, Shingu N, et al. Efficacy of azithromycin in sepsis-associated acute respiratory distress syndrome: a retrospective study and propensity score analysis. Springerplus. 2016;5(1):1–7.\nWalkey AJ, Wiener RS. Macrolide antibiotics and survival in patients with acute lung injury. Chest. 2012;141(5):1153–9.\nKawamura K, Ichikado K, Takaki M, Eguchi Y, Anan K, Suga M. Adjunctive therapy with azithromycin for moderate and severe acute respiratory distress syndrome: a retrospective, propensity score-matching analysis of prospectively collected data at a single center. Int J Antimicrob Agents. 2018;51(6):918–24.\nMatsuda S, Fujimori K, Kuwabara K, Ishikawa KB, Fushimi K. Diagnosis procedure combination as an infrastructure for the clinical study. Asian Pacific J Dis Manag. 2011;5(4):81–7.\nYamana H, Horiguchi H, Fushimi K, Yasunaga H. Comparison of procedure-based and diagnosis-based identifications of severe sepsis and disseminated intravascular coagulation in administrative data. J Epidemiol. 2016;26(10):530–7.\nAngus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303–10.\nShigematsu K, Nakano H, Watanabe Y. The eye response test alone is sufficient to predict stroke outcome—reintroduction of Japan coma scale: a cohort study. BMJ Open. 2013;3(4):e002736.\nUematsu H, Kunisawa S, Sasaki N, Ikai H, Imanaka Y. Development of a risk-adjusted in-hospital mortality prediction model for community-acquired pneumonia: a retrospective analysis using a Japanese administrative database. BMC Pulm Med. 2014;14:203.\nYamana H, Matsui H, Tagami T, Hirashima J, Fushimi K, Yasunaga H. De-escalation versus continuation of empirical antimicrobial therapy in community-acquired pneumonia. J Inf Secur. 2016;73(4):314–25.\nGriswold ME, Russell Localio A, Mulrow C. Propensity score adjustment with multilevel data: setting your sites on decreasing selection bias. Ann Intern Med. 2010;152(6):393–5.\nAustin PC. Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med. 2009;28(25):3083–107.\nAustin PC. Variance estimation when using inverse probability of treatment weighting (IPTW) with survival analysis. Stat Med. 2016;35(30):5642–55.\nKawashima M, Yatsunami J, Fukuno Y, Nagata M, Tominaga M, Hayashi S. Inhibitory effects of 14-membered ring macrolide antibiotics on bleomycin-induced acute lung injury. Lung. 2002;180(2):73–89.\nMiyashita N, Obase Y, Ouchi K, Kawasaki K, Kawai Y, Kobashi Y, et al. Clinical features of severe mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit. J Med Microbiol. 2007;56(12):1625–9.\nKohno S, Seki M, Takehara K, Yamada Y, Kubo K, Ishizaka A, et al. Prediction of requirement for mechanical ventilation in community-acquired pneumonia with acute respiratory failure: a multicenter prospective study. Respiration. 2013;85(1):27–35.\nCilloniz C, Ferrer M, Liapikou A, Garcia-Vidal C, Gabarrus A, Ceccato A, et al. Acute respiratory distress syndrome in mechanically ventilated patients with community-acquired pneumonia. Eur Respir J. 2018;51(3):1702215.\nParnham MJ, Haber VE, Giamarellos-Bourboulis EJ, Perletti G, Verleden GM, Vos R. Azithromycin: mechanisms of action and their relevance for clinical applications. Pharmacol Ther. 2014;143(2):225–45.\nYanagihara K, Matsumoto T, Aoki N, Sato J, Wakamura T, Kiyota H, et al. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2014. J Infect Chemother. 2019;25(9):657–68.",{"EN":112},"Community-acquired pneumonia (CAP) is the most common cause of acute respiratory distress syndrome (ARDS). Although previous studies have suggested that macrolide therapy is beneficial for ARDS, its benefit for severe CAP-associated ARDS remains uncertain. Previous studies were limited in that they had a small sample size and included patients with non-pulmonary ARDS and those with pulmonary ARDS. This study aimed to investigate the additional effect of azithromycin when used with β-lactam compared with the effect of β-lactam alone in mechanically ventilated patients with CAP-associated ARDS. We identified mechanically ventilated patients with CAP-associated ARDS between July 2010 and March 2015 using data in the Diagnosis Procedure Combination database, a Japanese nationwide inpatient database. We performed propensity score matching analysis to assess 28-day mortality and in-hospital mortality in mechanically ventilated patients with CAP-associated ARDS who received β-lactam with and without azithromycin within hospital 2 days after admission. The inverse probability of treatment weighting analysis was also conducted. Eligible patients (n = 1257) were divided into the azithromycin group (n = 226) and the control group (n = 1031). The one-to-four propensity score matching analysis included 139 azithromycin users and 556 non-users. No significant difference was observed between the groups with respect to 28-day mortality (34.5% vs. 37.6%, p = 0.556) or in-hospital mortality (46.0% vs. 49.1%, p = 0.569). The inverse probability of treatment weighting analysis showed similar results. Compared with treatment with β-lactam alone, treatment with azithromycin plus β-lactam had no significant additional effect on 28-day mortality or in-hospital mortality in mechanically ventilated patients with CAP-associated ARDS. To the best of our knowledge, this study is the first to determine the effect of azithromycin in mechanically ventilated patients with CAP-associated ARDS.",{"EN":114},"Additional effect of azithromycin over β-lactam alone for severe community-acquired pneumonia-associated acute respiratory distress syndrome: a retrospective cohort study",{"VOID":116},"10.1186\u002Fs41479-021-00093-8","PUBLICATION","VERIFIED","Auto 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In defence of early warning scores. Br J Anaesth 2007;99(5):747–8. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1093\u002Fbja\u002Faem286.PMID:17933804\nLim WS, Baudouin SV, George RC, Hill AT, Jamieson C, Le Jeune I et al.; Pneumonia Guidelines Commitee of the BTS Standards of Care Commitee. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax 2009;64 Suppl 3:iii1–55. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1136\u002Fthx.2009.121434. PMID:19783532\nLim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI et al. Defning community acquired pneumonia severity on presentaton to hospital: an internatonal derivaton and validaton study. Thorax 2003;58(5):377–82. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1136\u002Fthorax.58.5.377. PMID:12728155\nFine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE et al. A predicton rule to identfy low-risk patents with community-acquired pneumonia. N Engl J Med 1997;336(4):243–50. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1056\u002FNEJM199701233360402. PMID:8995086\nBirkhamshaw E, Wait CJ, Innes M, Wait PI. Severity assessment of lower respiratory tract infecton in Malawi: derivaton of a novel index (SWAT-Bp) which outperforms CRB-65. PLoS ONE 2013;8(12):e82178. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1371\u002Fjournal.pone.0082178. PMID:24324763\nAmerican College of Chest Physicians\u002FSociety of Critcal Care Medicine Consensus Conference: defnitons for sepsis and organ failure and guidelines for the use of innovatve therapies in sepsis. Crit Care Med 1992;20(6):864–74. https:\u002F\u002Fdoi.org\u002Fdx.doi.org\u002F10.1097\u002F00003246-199206000-00025. PMID:1597042\nEwig S, Ruiz M, Mensa J, Marcos MA, Martnez JA, Arancibia F et al. Severe community-acquired pneumonia. Assessment of severity criteria. Am J Respir Crit Care Med 1998;158(4):1102–8. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1164\u002Fajrccm.158.4.9803114. PMID:9769267\nMandell LA, Wunderink RG, Anzueto A, Bartlet JG, Campbell GD, Dean NC et al.; Infectous Diseases Society of America; American Thoracic Society. Infectous Diseases Society of America\u002FAmerican Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44 Suppl 2:S27–72. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1086\u002F511159. PMID:17278083\nCharles PG, Wolfe R, Whitby M, Fine MJ, Fuller AJ, Strling R et al.; Australian Community-Acquired Pneumonia Study Collaboraton. SMART-COP: a tool for predictng the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect Dis 2008;47(3):375–84. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1086\u002F589754. PMID:18558884\nEspaña PP, Capelastegui A, Quintana JM, Bilbao A, Diez R, Pascual S et al. Validaton and comparison of SCAP as a predictve score for identfying low-risk patents in community-acquired pneumonia. J Infect 2010;60(2):106–13. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1016\u002Fj.jinf.2009.11.013. PMID:19961875\nMart C, Garin N, Grosgurin O, Poncet A, Combescure C, Carballo S et al. Predicton of severe community-acquired pneumonia: a systematc review and meta-analysis. Crit Care 2012;16(4):R141. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1186\u002Fcc11447. PMID:22839689\nRoyal College of Physicians. Natonal Early Warning Score (NEWS): Standardising the assessment of acute-illness severity in the NHS. London: RCP; 2012.\nAujesky D, Fine MJ. The pneumonia severity index: a decade afer the inital derivaton and validaton. Clin Infect Dis 2008;47 Suppl 3:S133–9. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1086\u002F591394. PMID:18986279\nChalmers JD, Singanayagam A, Akram AR, Mandal P, Short PM, Choudhury G et al. Severity assessment tools for predictng mortality in hospitalised patents with community-acquired pneumonia. Systematc review and meta-analysis. Thorax 2010;65(10):878–83. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1136\u002Fthx.2009.133280. PMID:20729231\nAlavi-Moghaddam M, Bakhshi H, Rezaei B, Khashayar P. Pneumonia severity index compared to CURB-65 in predictng the outcome of community acquired pneumonia among patents referred to an Iranian emergency department: a prospectve survey. Braz J Infect Dis 2013;17(2):179–83. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1016\u002Fj.bjid.2012.10.012. PMID:23453945\nBuss I, Birkhamshaw E, Magadoro I, Innes M, Rylance J, Wait P. Validaton of a new index to predict mortality from community-acquired pneumonia in Malawi: the SWAT-BP score 43rd World Conference, IUATLD; 2012.\nBarlow G, Nathwani D, Davey P. The CURB65 pneumonia severity score outperforms generic sepsis and early warning scores in predictng mortality in community-acquired pneumonia. Thorax 2007;62(3):253–9. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1136\u002Fthx.2006.067371. PMID:16928720\nHowell MD, Donnino MW, Talmor D, Clardy P, Ngo L, Shapiro NI. Performance of severity of illness scoring systems in emergency department patents with infecton. Acad Emerg Med 2007;14(8):709–14. Available from: https:\u002F\u002Fdoi.org\u002Fwww.onlinelibrary.wiley.com\u002Fdoi\u002F10.1197\u002Fj.aem.2007.02.036\u002Fpdf. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1111\u002Fj.1553–2712.2007.tb01866.x. PMID:17576773\nChang CL, Sullivan GD, Karalus NC, Mills GD, McLachlan JD, Hancox RJ. Predictng early mortality in acute exacerbaton of chronic obstructve pulmonary disease using the CURB65 score. Respirology 2011;16(1):146–51. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1111\u002Fj.1440-1843.2010.01866.x. PMID:20920140\nChalmers JD, Singanayagam A, Hill AT. Predictng the need for mechanical ventlaton and\u002For inotropic support for young adults admited to the hospital with community-acquired pneumonia. Clin Infect Dis 2008;47(12):1571–4. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1086\u002F593195. PMID:18991510\nParsonage M, Nathwani D, Davey P, Barlow G. Evaluaton of the performance of CURB-65 with increasing age. Clin Microbiol Infect 2009;15(9):858–64. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1111\u002Fj.1469–0691.2009.02908.x. PMID:19702590\nKollef KE, Reichley RM, Micek ST, Kollef MH. The modifed APACHE II score outperforms Curb65 pneumonia severity score as a predictor of 30-day mortality in patents with methicillin-resistant Staphylococcus aureus pneumonia. Chest 2008;133(2):363–9. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1378\u002Fchest.07-1825. PMID:17951615\nBauer TT, Ewig S, Marre R, Sutorp N, Welte T, Group CS; CAPNETZ Study Group. CRB-65 predicts death from community-acquired pneumonia. J Intern Med 2006;260(1):93–101. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1111\u002Fj.1365–2796.2006.01657.x. PMID:16789984\nRylance J, Baker T, Mushi E, Mashaga D. Use of an early warning score and ability to walk predicts mortality in medical patents admited to hospitals in Tanzania. Trans R Soc Trop Med Hyg 2009;103(8):790–4. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1016\u002Fj.trstmh.2009.05.004. PMID:19540542\nScot JA, Hall AJ, Muyodi C, Lowe B, Ross M, Chohan B et al. Aetology, outcome, and risk factors for mortality among adults with acute pneumonia in Kenya. Lancet 2000;355(9211):1225–30. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1016\u002FS0140–6736(00)02089-4. PMID:10770305\nSanz F, Restrepo MI, Fernández E, Mortensen EM, Aguar MC, Cervera A et al.; Neumonía Adquirida en la Comunidad de la Comunidad Valenciana Study Group. Hypoxemia adds to the CURB-65 pneumonia severity score in hospitalized patents with mild pneumonia. Respir Care 2011;56(5):612–8. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.4187\u002Frespcare.00853. PMID:21276314\nHurst JM, Bosso JA. Antmicrobial stewardship in the management of community-acquired pneumonia. Curr Opin Infect Dis 2013;26(2):184–8. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1097\u002FQCO.0b013e32835d0a8f. PMID:23434896\nGao H, McDonnell A, Harrison DA, Moore T, Adam S, Daly K et al. Systematic review and evaluation of physiological track and trigger warning systems for identifying at-risk patients on the ward. Intensive Care Med 2007;33(4):667–79. s00134-007-0532-3. PMID:17318499\nBelle J, Cohen H, Shindo N, Lim M, Velazquez-Berumen A, Ndihokubwayo JB et al. Infuenza preparedness in low-resource setngs: a look at oxygen delivery in 12 African countries. J Infect Dev Ctries 2010;4(7):419–24. PMID:20818088\nRiviello ED, Letchford S, Achieng L, Newton MW. Critcal care in resource-poor setngs: lessons learned and future directons. Crit Care Med 2011;39(4):860–7. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1097\u002FCCM.0b013e318206d6d5. PMID:21297458\nFirth P, Ttendo S. Intensive care in low-income countries—a critcal need. N Engl J Med 2012;367(21):1974–6. https:\u002F\u002Fdoi.org\u002Fwww.dx.doi.org\u002F10.1056\u002FNEJMp1204957. PMID:23171093\nWHO. IMAI District Clinician Manual: Hospital Care for Adolescents and Adults (Guidelines for the Management of Common Illnesses with Limited Resources — Volume 1). Geneva: World Health Organizaton, 2011",{"EN":637},"Clinical prognostc scores are increasingly used to streamline care in well-resourced setngs. The potental benefts of identfying patents at risk of clinical deterioraton and poor outcome, delivering appropriate higher level clinical care, and increasing efciency are clear. In this focused review, we examine the use and applicability of severity scores applied to patents with community acquired pneumonia in resource poor setngs. We challenge clinical researchers working in such systems to consider the generalisability of existng severity scores in their populatons, and where performance of scores is suboptmal, to promote eforts to develop and validate new tools for the beneft of patents and healthcare systems.",{"EN":639},"Pneumonia severity scores in resource poor settings",{"VOID":641},"10.15172\u002Fpneu.2014.5\u002F481","https:\u002F\u002Fpneumonia.biomedcentral.com\u002Farticles\u002F10.15172\u002Fpneu.2014.5\u002F481",[644,659],{"id":645,"sortIndex":70,"researcher":18,"roles":646,"affiliations":647,"properties":656},"08bea578-7bd9-45ab-99fa-e1bf3654acd3",[125],[648],{"id":18,"sortIndex":19,"affiliation":649,"properties":18},{"id":650,"createTime":651,"updateTime":651,"relativeEntities":652,"slug":18,"properties":653,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"9ed16c91-1f1a-4641-840c-301fa9b2db4c","2024-01-15T01:09:44.275+00:00",[],{"title":654},{"VI":655},"Department of Acute Medicine, Arrowe Park Hospital, Merseyside, UK",{"title":657},{"VI":658},"Peter Waitt",{"id":660,"sortIndex":19,"researcher":18,"roles":661,"affiliations":662,"properties":671},"e6ec7c72-de16-4ac3-8954-07d51093320b",[125],[663],{"id":18,"sortIndex":19,"affiliation":664,"properties":18},{"id":665,"createTime":666,"updateTime":666,"relativeEntities":667,"slug":18,"properties":668,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"db178773-306d-413f-80e5-d43c651cc511","2024-01-15T01:09:44.261+00:00",[],{"title":669},{"VI":670},"Department of Respiratory Medicine, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool, UK",{"title":672},{"VI":673},"Jamie Rylance",{"url":642,"publisher":675,"properties":695},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":676,"slug":10,"properties":677,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":680,"manageAffiliations":681,"indexDatabases":682,"url":18,"thumbnailPath":18,"statistic":690,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":678,"title":679},{"VOID":13},{"EN":15},[],[],[683],{"id":43,"indexDatabase":684,"url":58,"indexYears":18,"academicFieldIds":689,"indexDatabaseRanking":18},{"id":45,"createTime":46,"updateTime":47,"relativeEntities":685,"label":686,"description":687,"key":54,"publicationTags":688,"standard":18},[],{"EN":50,"VI":50},{"VI":52,"EN":53},[56,57],[60],{"impactFactor":19,"impactFactorByYear":691,"i10Index":69,"i10IndexLast5Year":70,"totalPublication":71,"totalPublicationByYear":692,"totalCitation":82,"totalCitationByYear":693,"totalCitationPerPublication":89,"totalCitationPerPublicationByYear":694,"hindexLast5Year":39,"hindex":39},{"2016":63,"2017":64,"2018":65,"2019":66,"2020":67,"2021":68},{"2012":73,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":74,"2019":78,"2020":39,"2021":69,"2022":79,"2023":80,"2024":81},{"2013":81,"2014":73,"2015":84,"2016":85,"2017":86,"2018":87,"2019":88,"2022":73},{"2013":91,"2014":92,"2015":93,"2016":94,"2017":95,"2018":96,"2019":69,"2022":97},{"volume":696,"pages":698},{"VOID":697},"5",{"VOID":699},"30-37",{"id":701,"createTime":702,"updateTime":703,"relativeEntities":704,"slug":705,"properties":706,"entityType":117,"verifyStatus":118,"verifyTime":715,"verifyNote":119,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":716,"fullTextUrl":18,"authors":717,"publicationType":270,"publisherRelationship":792,"citationCount":18,"citationInfo":18,"publishDate":818,"publishYear":819,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":299},"a16b9823-9f09-4e7d-896d-d82a397a99ee","2024-01-27T22:35:39.611+00:00","2024-12-15T22:28:03.355+00:00",[],"Promoting-the-use-of-social-networks-in-pneumonia",{"references":707,"abstract":709,"title":711,"doi":713},{"VOID":708},"Van Noorden R. 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Pandemics in the age of twitter: content analysis of tweets during the 2009 H1N1 outbreak. PLoS One. 2010;5:e14118.\nLópez-Goñi I, Martínez-Viñas MJ, Antón J, Cid VJ, González AM, Brown-Jaque M, García-Lobo JM, Sánchez M, Vilchez JI, Robledo-Mahón T, Seder-Colomina M, Tapia-Paniagua ST, de Rojas AH, Mira A, Gallego-Parrilla JJ, TML D, Maicas S, Villalobo E, Quindós G, Balboa S, Romalde JL, Aguilar-Pérez C, Tomás A, Linares M, Zaragoza Ó, Gil-Serna J, Ferrer-Espada R, Camacho AI, Vinué L, García-Lara J. Twitter as a tool for teaching and communicating microbiology: the #microMOOCSEM initiative. J Microbiol Biol Educ. 2016;17:492–4.\nWilhelm M. Influenza in older patients: a call to action and recent updates for vaccinations. Am J Manag Care. 2018;24:S15–24.\nKallander K, Burgess DH, Qazi SA. Early identification and treatment of pneumonia: a call to action. Lancet Glob Health. 2016;4(1):e12–3.\nKällander K, Young M, Qazi S. Universal access to pneumonia prevention and care: a call for action. Lancet Respir Med. 2014;2:950–2.\nGinsburg AS, Sadruddin S, Klugman KP. Innovations in pneumonia diagnosis and treatment: a call to action on world pneumonia day, 2013. Lancet Glob Health. 2013;1:e326–7.\nHajjeh R, Whitney CG. Call to action on world pneumonia day. Emerging Infect Dis. 2012;18:1898–9.\nAdnan MM, Yin J, Jackson AM, Tse ZTH, Liang H, Fu K-W, Saroha N, Althouse BM, Fung IC-H. World pneumonia day 2011-2016: twitter contents and retweets. Int Health. 2019;11:297–305.\nInternational Vaccine Access Center at Johns Hopkins Bloomberg School of Public Health. 2011 The Global Coalition Against Child Pneumonia. Fight Pneumonia. Save a Child. Baltimore: International Vaccine Access Center at Johns Hopkins Bloomberg School of Public Health; 2012. Available from: https:\u002F\u002Fstoppneumonia.org\u002Fwp-content\u002Fuploads\u002F2012\u002F04\u002FWorld-Pneumonia-Day-2011-online-1.pdf.\nLopreite M, Puliga M, Riccaboni M. The global health networks: a comparative analysis of tuberculosis, malaria and pneumonia using social media data: IMT Institute for Advanced Studies Lucca; 2018. JanReport No.: 01\u002F2018. Available from: https:\u002F\u002Fideas.repec.org\u002Fp\u002Fial\u002Fwpaper\u002F1-2018.html.\nGolshaie A. The first global forum on childhood pneumonia. Lancet Respiratory Med. 2020; [cited 2020 Feb 5]; 0Available from: https:\u002F\u002Fwww.thelancet.com\u002Fjournals\u002Flanres\u002Farticle\u002FPIIS2213-2600(20)30054-0\u002Fabstract.\nWardlaw TM, Johansson EW, Hodge MJ. UNICEF. Pneumonia: the forgotten killer of children. New York: United Nations Children’s Fund (UNICEF); 2006.\nWatkins K, Sridhar D. Pneumonia: a global cause without champions. Lancet. 2018;392(10149):718–9.\nThe Lancet Global Health. The disgraceful neglect of childhood pneumonia. Lancet Glob Health. 2018;6(12):e1253.",{"EN":710},"Pneumonia is a serious health concern, but it does not attract the attention it warrants. Perhaps this is due to a lack of understanding of the real extent of this infectious disease in the general population. A literature review was performed to assess the role of social networks as a means to raise awareness over pneumonia worldwide and increase its visibility. In 2017, approximately 800,000 children under 5 years and approximately one million older people died of pneumonia. The importance of this pathology remains underestimated, despite the publication of many articles, comments, and editorials dedicated to rectifying the imbalance and to reduce its impact and associated mortality. Current misperceptions about pneumonia are alarming. Education and awareness are essential in the fight against this major public health threat; in this endeavor, social networks can be used to distribute science-based information about the disease and thus raise awareness among the general public about the dangers it poses. Approximately 3.8 billion people were using social media at the beginning of 2020, representing more than half of the world’s population. Social networks offer a valuable tool for disseminating scientific information about pneumonia, increasing its visibility, and in general raising awareness about this preventable disease.",{"EN":712},"Promoting the use of social networks in pneumonia",{"VOID":714},"10.1186\u002Fs41479-020-00066-3","2024-12-15T22:28:03.354+00:00","https:\u002F\u002Fpneumonia.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41479-020-00066-3",[718,743,760,775],{"id":719,"sortIndex":19,"researcher":18,"roles":720,"affiliations":721,"properties":740},"63cebf07-4c1e-44a3-bfb5-cba92af1e008",[125],[722,730],{"id":18,"sortIndex":19,"affiliation":723,"properties":18},{"id":724,"createTime":725,"updateTime":725,"relativeEntities":726,"slug":18,"properties":727,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"22e0b8e1-6534-4834-a100-e6cb6adb66d2","2023-12-12T06:15:56.374+00:00",[],{"title":728},{"VI":729},"August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain",{"id":731,"sortIndex":70,"affiliation":732,"properties":739},"f4ec1e2c-3545-4226-bd02-9bd7610cd9d3",{"id":733,"createTime":734,"updateTime":734,"relativeEntities":735,"slug":18,"properties":736,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"f52237d9-da13-4bdd-9a39-7673c042b95e","2024-01-27T22:35:39.630+00:00",[],{"title":737},{"VI":738},"Biomedical Research Networking Centers in Respiratory Diseases (CIBERES), the Association of Support and Information for Family members and Patients with Pneumonia (NEUMOAI), Barcelona, Spain",{},{"title":741},{"VI":742},"Catia Cillóniz",{"id":744,"sortIndex":73,"researcher":18,"roles":745,"affiliations":746,"properties":757},"15bc40be-b03e-459e-a22e-a51600b5abad",[125],[747],{"id":18,"sortIndex":19,"affiliation":748,"properties":18},{"id":749,"createTime":750,"updateTime":751,"relativeEntities":752,"slug":753,"properties":754,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"02dec3f3-8c5d-4182-807f-c52d1241cbb6","2023-12-18T00:50:18.726+00:00","2025-06-11T16:14:52.871+00:00",[],"Department-of-Infectious-Diseases-Hospital-Clinic-of-Barcelona-Barcelona-Spain",{"title":755},{"VI":756},"Department of Infectious Diseases, Hospital Clinic of Barcelona, Barcelona, Spain",{"title":758},{"VI":759},"Carolina Garcia-Vidal",{"id":761,"sortIndex":70,"researcher":18,"roles":762,"affiliations":763,"properties":772},"9a41ee7e-65e3-4619-822d-1a369f35f05e",[125],[764],{"id":18,"sortIndex":19,"affiliation":765,"properties":18},{"id":766,"createTime":767,"updateTime":767,"relativeEntities":768,"slug":18,"properties":769,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"390df5f0-7699-4b0d-aefe-99b7bd2a6f5b","2024-01-27T22:35:39.643+00:00",[],{"title":770},{"VI":771},"Every Breath Counts Coalition, New York City, USA",{"title":773},{"VI":774},"Leith Greenslade",{"id":776,"sortIndex":81,"researcher":18,"roles":777,"affiliations":778,"properties":789},"e47a8947-ef66-4d91-b074-735f7d78311a",[125],[779],{"id":18,"sortIndex":19,"affiliation":780,"properties":18},{"id":781,"createTime":782,"updateTime":783,"relativeEntities":784,"slug":785,"properties":786,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8e96f0b9-940e-4265-9431-f75eac0c6d11","2024-01-21T17:08:57.983+00:00","2024-10-13T09:33:10.049+00:00",[],"Department-of-Anesthesiology-and-Intensive-Care-Medicine-Fondazione-Policlinico-Universitario-A-Gemelli-Universit%C3%A0-Cattolica-del-Sacro-Cuore-Rome-Italy",{"title":787},{"VI":788},"Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy",{"title":790},{"VI":791},"Cristina Dominedò",{"url":716,"publisher":793,"properties":813},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":794,"slug":10,"properties":795,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":798,"manageAffiliations":799,"indexDatabases":800,"url":18,"thumbnailPath":18,"statistic":808,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":796,"title":797},{"VOID":13},{"EN":15},[],[],[801],{"id":43,"indexDatabase":802,"url":58,"indexYears":18,"academicFieldIds":807,"indexDatabaseRanking":18},{"id":45,"createTime":46,"updateTime":47,"relativeEntities":803,"label":804,"description":805,"key":54,"publicationTags":806,"standard":18},[],{"EN":50,"VI":50},{"VI":52,"EN":53},[56,57],[60],{"impactFactor":19,"impactFactorByYear":809,"i10Index":69,"i10IndexLast5Year":70,"totalPublication":71,"totalPublicationByYear":810,"totalCitation":82,"totalCitationByYear":811,"totalCitationPerPublication":89,"totalCitationPerPublicationByYear":812,"hindexLast5Year":39,"hindex":39},{"2016":63,"2017":64,"2018":65,"2019":66,"2020":67,"2021":68},{"2012":73,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":74,"2019":78,"2020":39,"2021":69,"2022":79,"2023":80,"2024":81},{"2013":81,"2014":73,"2015":84,"2016":85,"2017":86,"2018":87,"2019":88,"2022":73},{"2013":91,"2014":92,"2015":93,"2016":94,"2017":95,"2018":96,"2019":69,"2022":97},{"volume":814,"pages":816},{"VOID":815},"12",{"VOID":817},"1-7","2020-05-25",2020,{"id":821,"createTime":822,"updateTime":823,"relativeEntities":824,"slug":825,"properties":826,"entityType":117,"verifyStatus":118,"verifyTime":823,"verifyNote":119,"syncStatus":17,"languages":838,"translateLanguages":18,"viewCount":19,"primaryUrl":839,"fullTextUrl":18,"authors":840,"publicationType":270,"publisherRelationship":994,"citationCount":19,"citationInfo":1020,"publishDate":18,"publishYear":18,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":1022,"isForceReanalyzing":299},"79efa395-af66-4e33-9590-8ea3b377f013","2024-04-18T12:45:28.293+00:00","2025-01-04T22:25:04.044+00:00",[],"Host-genetic-variants-associated-with-susceptibility-and-severity-of-pneumococcal-pneumonia-in-adult-patients",{"keywords":827,"openalex":828,"abstract":830,"title":832,"pm":834,"doi":836},{},{"VOID":829},"W4390176201",{"EN":831},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\n                \u003Cjats:title>Background\u003C\u002Fjats:title>\n                \u003Cjats:p>Pneumococcal community-acquired pneumonia (P-CAP) is a major cause of morbidity and hospitalization. Several host genetics factors influencing risk of pneumococcal disease have been identified, with less information about its association with P-CAP. The aim of the study was to assess the influence of single nucleotide polymorphisms (SNP) within key genes involved in the innate immune response on the susceptibility to P-CAP and to study whether these polymorphic variants were associated with the severity and outcome of the episodes in a cohort of adult Caucasian patients.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Methods\u003C\u002Fjats:title>\n                \u003Cjats:p>Seventeen SNPs from 7 genes (IL-R1, IL-4, IL-10, IL-12B, NFKBIA, NFKBIE, NFKBIZ) were analyzed. For susceptibility, a case-control study including a cohort of 57 adult with P-CAP, and 280 ethnically matched controls was performed. Genetic influence on clinical severity and outcome was evaluated in a prospective observational study including all consecutive adult P-CAP patients from November 2015 to May 2017.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Results\u003C\u002Fjats:title>\n                \u003Cjats:p>The NFKBIA polymorphism rs696 and a haplotype combination were associated with susceptibility to P-CAP (OR = 0.62, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.005 and OR = 0.63, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.008, respectively). The SNP IL4 rs2227284 was associated with severe P-CAP (OR = 2.17, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.04). IL-R1 (rs3917267) and IL-10 (rs3024509) variants were related with respiratory failure (OR = 3.31, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.001 and OR = 0.18, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.003, respectively) as well as several haplotype combinations in NFKBIA, NFKBIZ, IL-R1 and IL-10 (\u003Cjats:italic>p\u003C\u002Fjats:italic> = 0,02, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0,01, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0,001, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0,03, respectively). CURB-65 values were associated with the IL-10 rs3024509 variant (beta = − 0.4, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.04), and with haplotype combinations of NFKBIZ and IL-10 (\u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.05, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.04, respectively). Genetic variants in IL-10 (rs3024509) and in IL-12B (rs730691) were associated with PSI values (beta = − 0.54, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.01, and beta = − 0.28, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.04, respectively), as were allelic combinations in IL-R1 (\u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.02) and IL-10 (\u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.01). Finally, several polymorphisms in the IL-R1 gene (rs13020778, rs2160227, & rs3917267) were associated with the time elapsed until clinical stability (beta = − 0.83, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.03; beta = − 1, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.02 and beta = 1.07, \u003Cjats:italic>p\u003C\u002Fjats:italic> = 0.008, respectively).\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>\u003Cjats:sec>\n                \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n                \u003Cjats:p>A genetic variant in NFKBIA was associated with susceptibility to P-CAP in adult Caucasian patients and genetic variants from key cytokines of the innate immune response (Il-4, IL-10, IL-R1 and IL-12B) and NF-κB inhibitors were associated with different phenotypes of severe P-CAP. If validated, these SNPs may help to identify people at risk of P-CAP or severe P-CAP on which preventive measures could be applied.\u003C\u002Fjats:p>\n              \u003C\u002Fjats:sec>",{"EN":833},"Host genetic variants associated with susceptibility and severity of pneumococcal pneumonia in adult patients",{"VOID":835},"38143267",{"VOID":837},"10.1186\u002Fs41479-023-00120-w",[322],"https:\u002F\u002Fpneumonia.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41479-023-00120-w",[841,860,888,908,928,943,977],{"id":842,"sortIndex":81,"researcher":18,"roles":843,"affiliations":844,"properties":855},"0741001b-24fd-4458-b649-47598dec09a6",[],[845],{"id":846,"sortIndex":19,"affiliation":847,"properties":18},"771d17bf-c9ae-4346-ac84-fd9b0d5f819a",{"id":848,"createTime":849,"updateTime":849,"relativeEntities":850,"slug":851,"properties":852,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"dec868a7-14d1-4026-8859-94bbdec69b0c","2024-04-18T12:45:28.352+00:00",[],"Internal-Medicine-Department-Hospital-Universitari-M%C3%BAtua-de-Terrassa-Barcelona-Spain",{"title":853},{"EN":854},"Internal Medicine Department, Hospital Universitari Mútua de Terrassa, Barcelona, Spain",{"openalex":856,"title":858},{"VOID":857},"A5047217560",{"EN":859},"Anna Sangil",{"id":861,"sortIndex":256,"researcher":18,"roles":862,"affiliations":863,"properties":883},"47f6e393-7bf7-4818-9eb4-84393e39c50a",[],[864,874],{"id":865,"sortIndex":19,"affiliation":866,"properties":18},"f519a1ed-03aa-4d1b-bc7f-eafb0179ab68",{"id":867,"createTime":868,"updateTime":868,"relativeEntities":869,"slug":870,"properties":871,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"a673d72a-0fa2-4979-9bea-0303e481dad8","2024-04-18T12:45:28.367+00:00",[],"Infectious-Diseases-Department-Hospital-Universitari-M%C3%BAtua-de-Terrassa-Barcelona-Spain",{"title":872},{"EN":873},"Infectious Diseases Department, Hospital Universitari Mútua de Terrassa, Barcelona, Spain",{"id":875,"sortIndex":70,"affiliation":876,"properties":18},"2822f54a-ba50-4c5c-82d2-39017c3157b7",{"id":877,"createTime":878,"updateTime":878,"relativeEntities":879,"slug":18,"properties":880,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"62c499f1-39aa-4acb-9174-12eef5ee2141","2023-12-12T22:00:59.603+00:00",[],{"title":881},{"VI":882},"Universitat Internacional de Catalunya, Barcelona, Spain",{"openalex":884,"title":886},{"VOID":885},"A5005729358",{"EN":887},"Esther Calbo",{"id":889,"sortIndex":79,"researcher":18,"roles":890,"affiliations":891,"properties":901},"53212818-c962-4faa-93e9-ed65da554cfe",[],[892],{"id":893,"sortIndex":19,"affiliation":894,"properties":18},"cc768759-8c08-4259-843a-f4608a0b94ce",{"id":895,"createTime":896,"updateTime":896,"relativeEntities":897,"slug":18,"properties":898,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"75794b26-207d-4cbc-9cde-c192c6d16b03","2024-01-24T09:21:07.323+00:00",[],{"title":899},{"VI":900},"Microbiology Department, CatLab, Barcelona, Spain",{"openalex":902,"orcid":904,"title":906},{"VOID":903},"A5031281928",{"VOID":905},"https:\u002F\u002Forcid.org\u002F0000-0001-5635-3137",{"EN":907},"J.A. Sánchez Pérez",{"id":909,"sortIndex":70,"researcher":18,"roles":910,"affiliations":911,"properties":921},"640a285a-7e1a-49e3-972c-0a8b08bd14af",[],[912],{"id":913,"sortIndex":19,"affiliation":914,"properties":18},"b74dcb5d-c609-481c-a936-3093ef6086ea",{"id":915,"createTime":916,"updateTime":916,"relativeEntities":917,"slug":18,"properties":918,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"32003287-3feb-4bc7-ba82-018b7cace3b7","2023-12-23T19:09:44.777+00:00",[],{"title":919},{"VI":920},"Fundació Docència i Recerca Mútua Terrassa, Barcelona, Spain",{"openalex":922,"orcid":924,"title":926},{"VOID":923},"A5039800222",{"VOID":925},"https:\u002F\u002Forcid.org\u002F0000-0002-6757-9198",{"EN":927},"Maria Arranz",{"id":929,"sortIndex":78,"researcher":18,"roles":930,"affiliations":931,"properties":938},"6954b7cb-297d-44e7-812b-315047e53692",[],[932],{"id":933,"sortIndex":19,"affiliation":934,"properties":18},"2935b63c-9c53-4bc3-9330-e5089103f2fc",{"id":895,"createTime":896,"updateTime":896,"relativeEntities":935,"slug":18,"properties":936,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":937},{"VI":900},{"openalex":939,"title":941},{"VOID":940},"A5022993950",{"EN":942},"Mariona 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Can your genes make you more prone to pneumococcal disease ? Expert Rev Anti Infect Ther. 2010;8:967–72.",{"doi":1190},"10.1586\u002Feri.10.84",{"id":18,"text":1192,"url":18,"identifiers":1193},"Bozza FA, Gomes RN, Japiassú AM, Soares M, Castro-Faria-Neto HC, Bozza PT, et al. Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis. Shock. 2004;22:309–13. https:\u002F\u002Fdoi.org\u002F10.1097\u002F01.shk.0000140305.01641.c8.",{"doi":1194},"10.1097\u002F01.shk.0000140305.01641.c8",{"id":18,"text":1196,"url":18,"identifiers":1197},"Van Der Poll T, Marchant A, Keogh CV, Goldman M, Lowry SF. Interleukin-10 impairs host defense in murine pneumococcal pneumonia. J Infect Dis. 1996;174:994–1000. https:\u002F\u002Fdoi.org\u002F10.1093\u002Finfdis\u002F174.5.994.",{"doi":1198},"10.1093\u002Finfdis\u002F174.5.994",{"id":18,"text":1200,"url":18,"identifiers":1201},"Temple SEL, Lim E, Cheong KY, Almeida CAM, Price P, Ardlie KG, et al. Alleles carried at positions −819 and −592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniae. Immunogenetics. 2003;55:629–32. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00251-003-0621-6.",{"doi":1202},"10.1007\u002Fs00251-003-0621-6",{"id":18,"text":1204,"url":18,"identifiers":1205},"Carrol ED, Payton A, Payne D, Miyajima F, Chaponda M, Mankhambo LA, et al. The IL1RN Promoter rs4251961 Correlates with IL-1 Receptor Antagonist Concentrations in Human Infection and Is Differentially Regulated by GATA-1. J Immunol. 2011;186:2329–35. https:\u002F\u002Fdoi.org\u002F10.4049\u002Fjimmunol.1002402.",{"doi":1206},"10.4049\u002Fjimmunol.1002402",{"id":18,"text":1208,"url":18,"identifiers":1209},"Zwijnenburg PJG, van der Poll T, Florquin S, Roord JJ, van Furth AM. IL-1 Receptor Type 1 Gene-Deficient Mice Demonstrate an Impaired Host Defense Against Pneumococcal Meningitis. J Immunol. 2003;170:4724–30. https:\u002F\u002Fdoi.org\u002F10.4049\u002Fjimmunol.170.9.4724.",{"doi":1210},"10.4049\u002Fjimmunol.170.9.4724",{"id":1212,"createTime":1213,"updateTime":1214,"relativeEntities":1215,"slug":1216,"properties":1217,"entityType":117,"verifyStatus":118,"verifyTime":1214,"verifyNote":119,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1226,"fullTextUrl":18,"authors":1227,"publicationType":270,"publisherRelationship":1304,"citationCount":18,"citationInfo":18,"publishDate":1328,"publishYear":528,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":299},"9527397b-c3ad-43d3-90a1-2bacc54b0dfb","2024-02-13T01:01:40.928+00:00","2024-12-27T22:18:58.216+00:00",[],"Corynebacteria-as-a-cause-of-pulmonary-infection-a-case-series-and-literature-review",{"references":1218,"abstract":1220,"title":1222,"doi":1224},{"VOID":1219},"National Center for Health Statistics. Health, United States, 2016: With Chartbook on Long-term Trends in Health. Hyattsville, MD. 2017.\nMusher DM, Roig IL, Cazares G, et al. Can an etiologic agent be identified in adults who are hospitalized for community-acquired pneumonia: results of a one-year study. J Inf Secur. 2013;67:11–8.\nJain S, Self WH, Wunderink RG, Team CES. Community-acquired pneumonia requiring hospitalization. N Engl J Med. 2015;373:2382.\nJanoff EN, Musher DM. Streptococcus pneumoniae. In: Bennett JEDR, Blaser MJ, editors. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia: Saunders; 2015. p. 2310–27.\nMusher DM, Abers MS, Bartlett JG. Evolving understanding of the causes of pneumonia in adults, with special attention to the role of pneumococcus. Clin Infect Dis. 2017;65:1736–44.\nSloan A, Wang G, Cheng K. Traditional approaches versus mass spectrometry in bacterial identification and typing. Clin Chim Acta. 2017;473:180–5.\nHarrington AT, Clarridge Iii JE, Mahlen SD. Chapter 91 - Corynebacterium spp. as established and emerging respiratory pathogens A2 - Tang, Yi-Wei. In: Sussman M, Liu D, Poxton I, Schwartzman J, editors. Molecular Medical Microbiology. 2nd ed. Boston: Academic Press; 2015. p. 1627–33.\nThorsteinsson SB, Musher DM, Fagan T. The diagnostic value of sputum culture in acute pneumonia. JAMA. 1975;233:894–5.\nvon Graevenitz A, Punter-Streit V, Riegel P, Funke G. Coryneform bacteria in throat cultures of healthy individuals. J Clin Microbiol. 1998;36:2087–8.\nWaters BL. Pathology of culture-proven JK Corynebacterium pneumonia. An autopsy case report. Am J Clin Pathol. 1989;91:616–9.\nCamello TC, Souza MC, Martins CA, et al. Corynebacterium pseudodiphtheriticum isolated from relevant clinical sites of infection: a human pathogen overlooked in emerging countries. Lett Appl Microbiol. 2009;48:458–64.\nAhmed K, Kawakami K, Watanabe K, et al. Corynebacterium pseudodiphtheriticum: a respiratory tract pathogen. Clin Infect Dis. 1995;20:41–6.\nManzella JP, Kellogg JA, Parsey KS. Corynebacterium pseudodiphtheriticum: a respiratory tract pathogen in adults. Clin Infect Dis. 1995;20:37–40.\nDiez-Aguilar M, Ruiz-Garbajosa P, Fernandez-Olmos A, et al. Non-diphtheriae Corynebacterium species: an emerging respiratory pathogen. Eur J Clin Microbiol Infect Dis. 2013;32:769–72.\nCreagh R, Saavedra JM, Rodriguez FJ, et al. Pneumonia casued by Corynebacterium striatum in a patient with AIDS. Enferm Infecc Microbiol Clin. 2000;18:297–8.\nMartinez-Martinez L, Suarez AI, Ortega MC, Rodriguez-Jimenez R. Fatal pulmonary infection caused by Corynebacterium striatum. Clin Infect Dis. 1994;19:806–7.\nRoig-Rico P, Safont-Gaso P, Marin-Tordera D, Ortiz-De la Tabla V. Corynebacterium striatum pneumonia in an HIV patient. Enferm Infecc Microbiol Clin. 2011;29:402.\nRenom F, Gomila M, Garau M, et al. Respiratory infection by Corynebacterium striatum: epidemiological and clinical determinants. New Microbes New Infect. 2014;2:106–14.\nMinkin R, Shapiro JM. Corynebacterium afermentans lung abscess and empyema in a patient with human immunodeficiency virus infection. South Med J. 2004;97:395–7.\nWallet F, Marquette CH, Courcol RJ. Multiresistant Corynebacterium xerosis as a cause of pneumonia in a patient with acute leukemia. Clin Infect Dis. 1994;18:845–6.\nIfantidou AM, Diamantidis MD, Tseliki G, et al. Corynebacterium jeikeium bacteremia in a hemodialyzed patient. Int J Infect Dis. 2010;14(Suppl 3):e265–8.\nMcNaughton RD, Villanueva RR, Donnelly R, et al. Cavitating pneumonia caused by Corynebacterium group JK. J Clin Microbiol. 1988;26:2216–7.\nYoshitomi Y, Kohno S, Koga H, et al. Fatal pneumonia caused by Corynebacterium group JK after treatment of Staphylococcus aureus pneumonia. Intern Med. 1992;31:930–2.\nKeslin MH, McCoy EL, McCusker JJ, Lutch JS. Corynebacterium pseudotuberculosis. A new cause of infectious and eosinophilic pneumonia. Am J Med. 1979;67:228–31.\nHeggelund L, Gaustad P, Havelsrud OE, et al. Corynebacterium pseudotuberculosis pneumonia in a veterinary student infected during laboratory work. Open Forum Infect Dis. 2015;2:ofv053.\nDjossou F, Bezian MC, Moynet D, et al. Corynebacterium mucifaciens in an immunocompetent patient with cavitary pneumonia. BMC Infect Dis. 2010;10:355.\nSiegel SM, Haile CA. Corynebacterium ulcerans pneumonia. South Med J. 1985;78:1267.\nKebbe J, Mador MJ. Corynebacterium macginleyi: a cause of ventilator associated pneumonia in an immunocompromised patient. Respir Med Case Rep. 2015;16:154–6.\nFunke G, von Graevenitz A, Clarridge JE 3rd, Bernard KA. Clinical microbiology of coryneform bacteria. Clin Microbiol Rev. 1997;10:125–59.\nWoese CR. Bacterial evolution. Microbiol Rev. 1987;51:221–71.\nBurkovski A. Corynebacterium pseudodiphtheriticum: putative probiotic, opportunistic infector, emerging pathogen. Virulence. 2015;6:673–4.\nSouza MC, dos Santos LS, Sousa LP, et al. Biofilm formation and fibrinogen and fibronectin binding activities by Corynebacterium pseudodiphtheriticum invasive strains. Antonie Van Leeuwenhoek. 2015;107:1387–99.\nBittar F, Cassagne C, Bosdure E, et al. Outbreak of Corynebacterium pseudodiphtheriticum infection in cystic fibrosis patients, France. Emerg Infect Dis. 2010;16:1231–6.\nCarranza Gonzalez R, Tena Gomez D, Prieto Gomez E, et al. Pneumonia by Corynebacterium pseudodiphteriticum: an infection to consider. An Med Interna. 2006;23:124–6.\nMiller RA, Rompalo A, Coyle MB. Corynebacterium pseudodiphtheriticum pneumonia in an immunologically intact host. Diagn Microbiol Infect Dis. 1986;4:165–71.\nChiner E, Arriero JM, Signes-Costa J, et al. Corynebacterium pseudodiphtheriticum pneumonia in an immunocompetent patient. Monaldi Arch Chest Dis. 1999;54:325–7.\nGutierrez-Rodero F, Ortiz de la Tabla V, Martinez C, et al. Corynebacterium pseudodiphtheriticum: an easily missed respiratory pathogen in HIV-infected patients. Diagn Microbiol Infect Dis. 1999;33:209–16.\nRoig P, Lopez MM, Arriero JM, et al. Corynebacterium pseudodiphtheriticum pneumonia in a patient diagnosed with HIV infection. An Med Interna. 1993;10:499–500.\nHeffron R. Pneumonia with special reference to pneumococcus lobar pneumonia. New York: The Commonwealth Fund; 1939.\nMusher DM, Kubitschek KR, Crennan J, Baughn RE. Pneumonia and acute febrile tracheobronchitis due to Haemophilus influenzae. Ann Intern Med. 1983;99:444–50.\nWallace RJ Jr, Musher DM. In honor of Dr. Sarah Branham, a star is born. The realization of Branhamella catarrhalis as a respiratory pathogen. Chest. 1986;90:447–50.\nCoyle MB, Lipsky BA. Coryneform bacteria in infectious diseases: clinical and laboratory aspects. Clin Microbiol Rev. 1990;3:227–46.\nVila J, Juiz P, Salas C, et al. Identification of clinically relevant Corynebacterium spp., Arcanobacterium haemolyticum, and Rhodococcus equi by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol. 2012;50:1745–7.\nBao R, Gao X, Hu B, Zhou Z. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for identification of Corynebacterium species. J Thorac Dis. 2017;9:3239–45.\nReddy BS, Chaudhury A, Kalawat U, et al. Isolation, speciation, and antibiogram of clinically relevant non-diphtherial Corynebacteria (Diphtheroids). Indian J Med Microbiol. 2012;30:52–7.\nLosada I, Daza RM, Merino J, et al. Corynebacterium CDC G1: pathogen or colonizer? Enferm Infecc Microbiol Clin. 1996;14:510–1.\nRiebel W, Frantz N, Adelstein D, Spagnuolo PJ. Corynebacterium JK: a cause of nosocomial device-related infection. Rev Infect Dis. 1986;8:42–9.\nMalkocoglu G, Gencer H, Kaya A, et al. Corynebacterium propinquum bronchopneumonia in a child with ataxia telangiectasia. Turk J Pediatr. 2016;58:558–61.\nFuriasse D, Gasparotto AM, Monterisi A, et al. Pneumonia caused byCorynebacterium pseudodiphtheriticum. Rev Argent Microbiol. 2016;48:290–2.\nChudnicka A, Szmygin-Milanowska K, Kieszko R, et al. The role of opportunistic species of Corynebacterium pseudodiphtheriticum in the pathogenesis of CAP (community acquired pneumonia). Ann Univ Mariae Curie Sklodowska Med. 2003;58:142–8.\nAspiroz Sancho C, Agustin Berne A, Navarro Pardos C, et al. Pneumonia caused by Corynebacterium pseudodiphteriticum, an entity worth knowing. An Med Interna. 2002;19:463–5.\nMartaresche C, Fournier PE, Jacomo V, et al. A case of Corynebacterium pseudodiphtheriticum nosocomial pneumonia. Emerg Infect Dis. 1999;5:722–3.\nCohen Y, Force G, Gros I, et al. Corynebacterium pseudodiphtheriticum pulmonary infection in AIDS patients. Lancet. 1992;340:114–5.\nDonaghy M, Cohen J. Pulmonary infection with Corynebacterium hofmannii complicating systemic lupus erythematosus. J Infect Dis. 1983;147:962.\nNishiyama A, Ishida T, Ito A, Arita M. Bronchopneumonia caused by Corynebacterium pseudodiphtheriticum. Intern Med. 2013;52:1847.\nCowling P, Hall L. Corynebacterium striatum: a clinically significant isolate from sputum in chronic obstructive airways disease. J Inf Secur. 1993;26:335–6.\nTarr PE, Stock F, Cooke RH, et al. Multidrug-resistant Corynebacterium striatum pneumonia in a heart transplant recipient. Transpl Infect Dis. 2003;5:53–8.\nVerma R, Kravitz GR. Corynebacterium striatum empyema and osteomyelitis in a patient with advanced rheumatoid arthritis. BMJ Case Rep. 2016; https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbcr-2016-214691.\nMattos-Guaraldi AL, Sampaio JL, Santos CS, et al. First detection of Corynebacterium ulcerans producing a diphtheria-like toxin in a case of human with pulmonary infection in the Rio de Janeiro metropolitan area, Brazil. Mem Inst Oswaldo Cruz. 2008;103:396–400.\nJacobs NF Jr, Perlino CA. “Diphtheroid” pneumonia. South Med J. 1979;72:475–6.\nNazemi MM, Musher DM. Empyema due to aerobic diphtheroids following dental extraction. Am Rev Respir Dis. 1973;108:1221–3.",{"EN":1221},"In most cases of community-acquired pneumonia (CAP), an etiologic agent is not determined; the most common report from the microbiological evaluation of sputum cites “normal respiratory flora.” Non-diphtheria Corynebacterium spp., a component of this flora, is commonly viewed as a contaminant, but it may be the cause of pneumonia and the frequency with which it causes CAP may be underestimated. This report present 3 cases of CAP in which Corynebacterium spp. was clearly the predominant isolate; identification was confirmed by matrix-assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometry. Two cases were caused by C. propinquum and one by C. striatum. Two patients had a tracheostomy and one was on hemodialysis. Patients who received an appropriate antibiotic responded well. When identified as the predominant isolate in sputum from a patient with CAP, Corynebacterium spp. should be considered as a potential cause of the infection. In cases with patients who have compromised airway clearance or who are immunocompromised, microaspiration may be responsible. While some Corynebacterium spp. are suspectible to antibiotics usually prescribed for CAP, others are susceptible only to vancomycin or aminoglycosides. Vancomycin is thus the appropriate empiric antibiotic, pending speciation and susceptibility test results. The number of reported cases with result of antibiotic susceptibility testing, however, remains limited, and further investigation is needed. Non-diphtheria Corynebacterium spp. represent a noteworthy clinical cause of pneumonia. Identification by Gram stain and as a predominant organism on culture demands careful consideration for management.",{"EN":1223},"Corynebacteria as a cause of pulmonary infection: a case series and literature review",{"VOID":1225},"10.1186\u002Fs41479-018-0054-5","https:\u002F\u002Fpneumonia.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs41479-018-0054-5",[1228,1259,1274,1289],{"id":1229,"sortIndex":73,"researcher":18,"roles":1230,"affiliations":1231,"properties":1256},"26039623-a388-4f33-a7e2-65e8120ce621",[125],[1232,1246],{"id":1233,"sortIndex":19,"affiliation":1234,"properties":1243},"013e7dcd-b18f-422c-a7ad-ed87783363dd",{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1238,"slug":1239,"properties":1240,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"74100390-f38d-4359-9936-3dbcd4528cf2","2024-08-31T03:08:48.301+00:00","2025-01-30T15:06:59.091+00:00",[],"Baylor-College-of-Medicine-Houston-United-States",{"title":1241},{"EN":1242},"Baylor College of Medicine, Houston, United States",{"title":1244},{"VI":1245},"Baylor College of Medicine, Houston, USA",{"id":1247,"sortIndex":70,"affiliation":1248,"properties":1255},"a3191a77-236f-4c11-91ea-6ba795edc731",{"id":1249,"createTime":1250,"updateTime":1250,"relativeEntities":1251,"slug":18,"properties":1252,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"89fa1325-e006-49e8-823f-38c2853f124a","2024-02-13T01:01:41.046+00:00",[],{"title":1253},{"VI":1254},"Infectious Disease Section, Michael E. DeBakey Veterans Affairs Medical Center, Houston, USA",{},{"title":1257},{"VI":1258},"Daniel M. Musher",{"id":1260,"sortIndex":70,"researcher":18,"roles":1261,"affiliations":1262,"properties":1271},"663ac32d-9615-4141-ba34-0defbb8a4137",[125],[1263],{"id":1264,"sortIndex":19,"affiliation":1265,"properties":1269},"a975bcae-e5ee-4c69-922c-8e86a265bb8f",{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1266,"slug":1239,"properties":1267,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1268},{"EN":1242},{"title":1270},{"VI":1245},{"title":1272},{"VI":1273},"Robert L. Kruse",{"id":1275,"sortIndex":81,"researcher":18,"roles":1276,"affiliations":1277,"properties":1286},"29198292-97ef-432d-9663-96da01ace933",[125],[1278],{"id":1279,"sortIndex":19,"affiliation":1280,"properties":1284},"76bab01d-f77c-4d89-882a-95d9b5c77acd",{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1281,"slug":1239,"properties":1282,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1283},{"EN":1242},{"title":1285},{"VI":1245},{"title":1287},{"VI":1288},"Weijie V. Lin",{"id":1290,"sortIndex":19,"researcher":18,"roles":1291,"affiliations":1292,"properties":1301},"1e249285-b857-4971-b1d6-2eb8ff073384",[125],[1293],{"id":1294,"sortIndex":19,"affiliation":1295,"properties":1299},"c62a0178-5687-4390-87e0-b30537191afd",{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1296,"slug":1239,"properties":1297,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1298},{"EN":1242},{"title":1300},{"VI":1245},{"title":1302},{"VI":1303},"Katharine Yang",{"url":1226,"publisher":1305,"properties":1325},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1306,"slug":10,"properties":1307,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1310,"manageAffiliations":1311,"indexDatabases":1312,"url":18,"thumbnailPath":18,"statistic":1320,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1308,"title":1309},{"VOID":13},{"EN":15},[],[],[1313],{"id":43,"indexDatabase":1314,"url":58,"indexYears":18,"academicFieldIds":1319,"indexDatabaseRanking":18},{"id":45,"createTime":46,"updateTime":47,"relativeEntities":1315,"label":1316,"description":1317,"key":54,"publicationTags":1318,"standard":18},[],{"EN":50,"VI":50},{"VI":52,"EN":53},[56,57],[60],{"impactFactor":19,"impactFactorByYear":1321,"i10Index":69,"i10IndexLast5Year":70,"totalPublication":71,"totalPublicationByYear":1322,"totalCitation":82,"totalCitationByYear":1323,"totalCitationPerPublication":89,"totalCitationPerPublicationByYear":1324,"hindexLast5Year":39,"hindex":39},{"2016":63,"2017":64,"2018":65,"2019":66,"2020":67,"2021":68},{"2012":73,"2013":73,"2014":74,"2015":75,"2016":76,"2017":77,"2018":74,"2019":78,"2020":39,"2021":69,"2022":79,"2023":80,"2024":81},{"2013":81,"2014":73,"2015":84,"2016":85,"2017":86,"2018":87,"2019":88,"2022":73},{"2013":91,"2014":92,"2015":93,"2016":94,"2017":95,"2018":96,"2019":69,"2022":97},{"volume":1326,"pages":1327},{"VOID":524},{"VOID":296},"2018-10-05",{"id":1330,"createTime":1331,"updateTime":1332,"relativeEntities":1333,"slug":1334,"properties":1335,"entityType":117,"verifyStatus":118,"verifyTime":1346,"verifyNote":119,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1347,"fullTextUrl":18,"authors":1348,"publicationType":270,"publisherRelationship":1475,"citationCount":18,"citationInfo":18,"publishDate":1496,"publishYear":1497,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":299},"20a6dbf9-2d05-400d-a806-02e4c09b0dac","2024-04-07T14:18:43.049+00:00","2025-02-04T22:07:53.997+00:00",[],"Oxygen-saturations-of-medical-inpatients-in-a-Malawian-hospital-cross-sectional-study-of-oxygen-supply-and-demand",{"references":1336,"keywords":1338,"abstract":1340,"title":1342,"doi":1344},{"VOID":1337},"Duke T, Graham SM, Cherian MN, Ginsburg AS, English M. Oxygen is an essential medicine: a call for international action. Int J Tuberc Lung Dis 2010; 14(11):1362–68.\nPocket Book of Hospital Care for Children: Guidelines for the Management of Common Illnesses with Limited Resources; World Health Organisation’s Department of Child and Adolescent Health and Development; 2005.\nClinical management of human infection with avian influenza A (H5N1) virus; World Health Organisation; 2007.\nLaman M, Ripa P, Vince J, Tefuarani NX. Can clinical signs predict hypoxaemia in Papua New Guinean children with moderate and severe pneumonia? Ann Trop Paediatr 2005; 25(1):23–7.\nT Duke, F Wandi, M Johnson, S Matai. M Kaupa. Improved oxygen systems for childhood pneumonia: a multihospital effectiveness study in Papua New Guinea. The Lancet 2008; 372:1328–33.\nDuke T, Peel D, Graham S, Howie S, Enarson P, Jacobson R. Oxygen concentrators: a practical guide for clinicians and technicians in developing countries. Annals of Tropical Paediatrics 2010; 30:87–101.",{"EN":1339},"",{"EN":1341},"Oxygen is a World Health Organisation listed essential drug yet provision of oxygen in developing countries often fails to meet demand. The aim of this study was to evaluate the need for supplementary oxygen against oxygen delivery capacity at a large teaching hospital in Malawi. A cross-sectional study of all adult medical inpatients and assessment of oxygen provision over a 24-hour period was conducted. 144 patients were included in the study, 14 of whom met local and international criteria for oxygen therapy (oxygen saturations of \u003C90%). Four were receiving oxygen. Of the 8 oxygen concentrators available, only 4 were functional. In conclusion, we identified a need for oxygen that was greater than the supply.",{"EN":1343},"Oxygen saturations of medical inpatients in a Malawian hospital: cross-sectional study of oxygen supply and demand",{"VOID":1345},"10.15172\u002Fpneu.2012.1\u002F208","2025-02-04T22:07:53.996+00:00","https:\u002F\u002Fpneumonia.biomedcentral.com\u002Farticles\u002F10.15172\u002Fpneu.2012.1\u002F208",[1349,1364,1380,1402,1419,1436,1451,1463],{"id":1350,"sortIndex":78,"researcher":18,"roles":1351,"affiliations":1352,"properties":1361},"e8b64e7f-35d4-4520-9c70-260c3645cf3a",[125],[1353],{"id":18,"sortIndex":19,"affiliation":1354,"properties":18},{"id":1355,"createTime":1356,"updateTime":1356,"relativeEntities":1357,"slug":18,"properties":1358,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"a71fb60f-225d-40d0-8053-bd0f84889211","2023-12-08T05:09:01.169+00:00",[],{"title":1359},{"VI":1360},"Queen Elizabeth Central Hospital, Blantyre, Malawi",{"title":1362},{"VI":1363},"Andrew Gonani",{"id":1365,"sortIndex":81,"researcher":18,"roles":1366,"affiliations":1367,"properties":1377},"315709b1-d8cc-4171-a364-aa5d58a73844",[125],[1368],{"id":18,"sortIndex":19,"affiliation":1369,"properties":18},{"id":1370,"createTime":1371,"updateTime":1371,"relativeEntities":1372,"slug":1373,"properties":1374,"entityType":38,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8c0d9d51-8e79-4056-b5db-fd99791d56cf","2024-04-07T14:18:43.122+00:00",[],"Dept-Respiratory-Medicine-University-Hospital-Aintree-Liverpool-UK",{"title":1375},{"VI":1376},"Dept Respiratory Medicine, University Hospital Aintree, Liverpool, UK",{"title":1378},{"VI":1379},"Duncan G. 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