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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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The main objectives of the journal include: providing an intellectual platform for Vietnamese and international scholars; promoting interdisciplinary studies in social sciences and humanities; becoming the leading journal in social sciences and humanities in Vietnam; being indexed by worldwide databases and having academic recognition internationally in the near future.\\nThe journal is currently indexed by Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services and Vietnam National University’s digital archive.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Journal of Social Sciences and Humanities-Vietnam\"},{\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"ISSN 2354-1172, email: tapchikhxhnv@gmail.com, tckhxhnv@vnu.edu.vn\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Được thành lập ngày 31\u002F8\u002F2015 (giấy phép hoạt động số 155\u002FGP-BVHTT ngày 11 tháng 5 năm 2015 của Bộ Thông tin và Truyền thông, mã số tiêu chuẩn quốc tế ISSN 2354-1172), Tạp chí Khoa học Xã hội và Nhân văn (Journal of Social Sciences and Humanities) là ấn phẩm khoa học chính thức, duy nhất của Trường Đại học Khoa học Xã hội và Nhân văn, ĐHQG Hà Nội, phát triển và kế thừa Chuyên san Khoa học Xã hội và Nhân văn, Tạp chí Khoa học, ĐHQG Hà Nội.\\nTạp chí xuất bản định kỳ (04 số tiếng Việt\u002Fnăm và 02 số tiếng Anh\u002Fnăm), có nhiệm vụ \"},{\"attributes\":{\"italic\":true},\"insert\":\"công bố, giới thiệu các công trình nghiên cứu khoa học khoa học xã hội và nhân văn của các tác giả là các nhà khoa học trong và ngoài nước, phục vụ giảng dạy, học tập và nghiên cứu khoa học\"},{\"insert\":\". 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And the first issue was published in January 1998 with ISSN 1859-0128. Since then, STDJ has become the most important scientific forum of scientists from VNU-HCM as well as other universities. The magazine has undergone 20 years of development and has become a bridge for scientific exchanges, as well as enriching reference materials for the faculty, doctoral students, students of VNU-HCM in particular and other universities, institutes...\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal since 2020.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\" \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"2. 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integrity of RNA molecules is of paramount importance for experiments that try to reflect the snapshot of gene expression at the moment of RNA extraction. Until recently, there has been no reliable standard for estimating the integrity of RNA samples and the ratio of 28S:18S ribosomal RNA, the common measure for this purpose, has been shown to be inconsistent. The advent of microcapillary electrophoretic RNA separation provides the basis for an automated high-throughput approach, in order to estimate the integrity of RNA samples in an unambiguous way.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>A method is introduced that automatically selects features from signal measurements and constructs regression models based on a Bayesian learning technique. Feature spaces of different dimensionality are compared in the Bayesian framework, which allows selecting a final feature combination corresponding to models with high posterior probability.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>This approach is applied to a large collection of electrophoretic RNA measurements recorded with an Agilent 2100 bioanalyzer to extract an algorithm that describes RNA integrity. The resulting algorithm is a user-independent, automated and reliable procedure for standardization of RNA quality control that allows the calculation of an RNA integrity number (RIN).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>Our results show the importance of taking characteristics of several regions of the recorded electropherogram into account in order to get a robust and reliable prediction of RNA integrity, especially if compared to traditional methods.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Đặt vấn đề\u003C\u002Fjats:title>\u003Cjats:p>Độ toàn vẹn của các phân tử RNA có tầm quan trọng hàng đầu trong các thí nghiệm cố gắng phản ánh bức tranh biểu hiện gen tại thời điểm chiết xuất RNA. Đến gần đây, chưa có tiêu chuẩn nào đáng tin cậy để ước lượng độ toàn vẹn của các mẫu RNA và tỷ lệ RNA ribosomal 28S:18S, thước đo phổ biến cho mục đích này, đã cho thấy sự không nhất quán. Sự xuất hiện của điện di vi mao cung cấp cơ sở cho một phương pháp tự động có độ thông lượng cao, nhằm ước lượng độ toàn vẹn của các mẫu RNA một cách dễ hiểu.",{"EN":763,"VI":764},"The RIN: an RNA integrity number for assigning integrity values to RNA measurements","Số RIN: một số đo độ toàn vẹn RNA để gán giá trị độ toàn vẹn cho các phép đo RNA",{"VOID":766},"16448564",{"VOID":768},"10.1186\u002F1471-2199-7-3","PUBLICATION","2024-12-16T03:11:27.972+00:00","Auto Verify",[102],[101],"https:\u002F\u002Fbmcmolbiol.biomedcentral.com\u002Farticles\u002F10.1186\u002F1471-2199-7-3",[776,795,816,833,852,869,884,899,914,933],{"id":777,"sortIndex":162,"researcher":26,"roles":778,"affiliations":779,"properties":790},"d945e830-8cd2-4954-b4c3-e2208714aa4c",[],[780],{"id":781,"sortIndex":36,"affiliation":782,"properties":26},"b2b4b443-3f5e-4213-a734-3aa5f8c089e1",{"id":783,"createTime":784,"updateTime":784,"relativeEntities":785,"slug":786,"properties":787,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d4099a8e-e083-48c7-b8cd-a715a39d0233","2024-04-21T19:49:16.854+00:00",[],"Agilent-Technologies-Hewlett-Packard-Strasse-8-Waldbronn-76337-Germany",{"title":788},{"EN":789},"Agilent Technologies, Hewlett-Packard-Strasse 8, Waldbronn, 76337, Germany",{"openalex":791,"title":793},{"VOID":792},"A5042105068",{"EN":794},"Marcus Gassmann",{"id":796,"sortIndex":135,"researcher":26,"roles":797,"affiliations":798,"properties":811},"094a9981-c8fb-4823-9f63-419c46bf0155",[],[799],{"id":800,"sortIndex":36,"affiliation":801,"properties":808},"b75ded8d-a6c5-447d-a6fb-f56ca01b5c6b",{"id":802,"createTime":803,"updateTime":803,"relativeEntities":804,"slug":26,"properties":805,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"146fab18-1a05-45e2-b43c-b4dee69a8d51","2023-12-14T10:37:22.100+00:00",[],{"title":806},{"VI":807},"Agilent Technologies, 5301 Stevens Creek Blvd, Santa Clara, CA 95051, United States",{"title":809},{"EN":810},"Agilent Technologies, 5301 Stevens Creek Blvd, Santa Clara, CA, 95051, USA",{"openalex":812,"title":814},{"VOID":813},"A5061202283",{"EN":815},"Samar Lightfoot",{"id":817,"sortIndex":115,"researcher":26,"roles":818,"affiliations":819,"properties":828},"b3e97353-26cc-4c57-8d48-2fb91da68640",[],[820],{"id":821,"sortIndex":36,"affiliation":822,"properties":826},"cad14849-d842-447b-a167-daf90cee1732",{"id":802,"createTime":803,"updateTime":803,"relativeEntities":823,"slug":26,"properties":824,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":825},{"VI":807},{"title":827},{"EN":810},{"openalex":829,"title":831},{"VOID":830},"A5084846842",{"EN":832},"Odilo Mueller",{"id":834,"sortIndex":50,"researcher":26,"roles":835,"affiliations":836,"properties":847},"1ae0e170-02d7-4302-9e34-34589de247b3",[],[837],{"id":838,"sortIndex":36,"affiliation":839,"properties":26},"d8ce0a29-5de0-4cc5-beea-fb1cc03e3579",{"id":840,"createTime":841,"updateTime":841,"relativeEntities":842,"slug":843,"properties":844,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"41f4275a-e9b8-4d82-aa2d-02135b8454ae","2024-04-21T19:49:16.934+00:00",[],"quantiom-bioinformatics-GmbH-Co-KG-Ringstrasse-61-Weingarten-76356-Germany",{"title":845},{"EN":846},"quantiom bioinformatics GmbH & Co. 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Nature Genetics. 2003, 35: 292-293. 10.1038\u002Fng1203-292",{"doi":989},"10.1038\u002Fng1203-292",{"id":26,"text":991,"url":26,"identifiers":992},"Imbeaud S, Graudens E, Boulanger V, Barlet X, Zaborski P, Eveno E, Mueller O, Schroeder A, Auffray C: Towards standardization of RNA quality assessment using user-independent classifiers of microcapillary electrophoresis traces. Nucleic Acids Research (Published online 30 March). 2005, 33: e56, 10.1093\u002Fnar\u002Fgni054",{"doi":993},"10.1093\u002Fnar\u002Fgni054",{"id":26,"text":995,"url":26,"identifiers":996},"Sambrook J, Fritsch E, Maniatis T: Molecular Cloning, a laboratory manual. 1989, Cold Spring Harbor Laboratory Press, New York, 2",{},{"id":26,"text":998,"url":26,"identifiers":999},"Mueller O, Hahnenberger K, Dittmann M, Yee H, Dubrow R, Nagle R, Isley D: A microfluidic system for high-speed reproducible DNA sizing and quantitation. Electrophoresis. 2000, 21: 128-134. 10.1002\u002F(SICI)1522-2683(20000101)21:1\u003C128::AID-ELPS128>3.0.CO;2-M",{"doi":1000},"10.1002\u002F(SICI)1522-2683(20000101)21:1\u003C128::AID-ELPS128>3.0.CO;2-M",{"id":26,"text":1002,"url":26,"identifiers":1003},"Miller C, Diglisic S, Leister F, Webster M, Yolken R: Evaluating RNA status for RT-PCR in extracts of postmortem human brain tissue. Biotechniques. 2004, 36 (4): 628-633.",{"doi":1004},"10.2144\u002F04364ST03",{"id":26,"text":1006,"url":26,"identifiers":1007},"RZPD, Im Neuenheimer Feld 580, D-69120 Heidelberg.http:\u002F\u002Fwww.rzpd.de",{},{"id":26,"text":1009,"url":26,"identifiers":1010},"Swets J, Pickett R: Evaluation of Diagnostic Systems: Methods from Signal Detection Theory. 1982, Academic Press, New York",{},{"id":26,"text":1012,"url":26,"identifiers":1013},"RIN software. http:\u002F\u002Fwww.agilent.com\u002Fchem\u002Flabonachip",{},{"id":26,"text":1015,"url":26,"identifiers":1016},"The RIN-project. http:\u002F\u002Fwww.agilent.com\u002Fchem\u002FRIN, http:\u002F\u002Fwww.quantiom.com\u002FRIN",{},{"id":26,"text":1018,"url":26,"identifiers":1019},"Mueller O, Lightfoot S, Schröder A: RNA Integrity Number (RIN) Standardization of RNA Quality Control. Tech. Rep. 5989-1165EN, Agilent Technologies, Application Note. 2004, http:\u002F\u002Fwww.agilent.com\u002Fchem\u002Flabonachip",{},{"id":26,"text":1021,"url":26,"identifiers":1022},"Schröder A: Qualitätsbestimmung von RNA-Proben mittels adaptiver Verfahren. Diplomarbeit Universität Karlsruhe. 2003",{},{"id":26,"text":1024,"url":26,"identifiers":1025},"Agilent : 2100 expert software. Tech. Rep. 5989-0112EN, Agilent Technologies, Software Data Sheet. 2004, http:\u002F\u002Fwww.agilent.com\u002Fchem\u002Flabonachip",{},{"id":26,"text":1027,"url":26,"identifiers":1028},"Scott D, Thompson J: Probability density estimation in higher dimensions. Computer Science and Statistics: Proceedings of the Fifteenth Symposium on the Interface. Edited by: Gentle J. 1983, 173-179.",{},{"id":26,"text":1030,"url":26,"identifiers":1031},"Silverman B: Density Estimation for Statistics and Data Analysis. 1986, Chapman and Hall",{"doi":1032},"10.1007\u002F978-1-4899-3324-9",{"id":26,"text":1034,"url":26,"identifiers":1035},"Cover T, Thomas J: Elements of Information Theory. 1991, Wiley Series in Telecommunications, John Wiley & Sons",{"doi":1036},"10.1002\u002F0471200611",{"id":26,"text":1038,"url":26,"identifiers":1039},"Ragg T: Bayesian Learning and Evolutionary Parameter Optimization. AI Communications. 2002, 15: 61-74.",{},{"id":26,"text":1041,"url":26,"identifiers":1042},"Bishop CM: Neural Networks for Pattern Recognition. 1995, Oxford Press",{"doi":1043},"10.1093\u002Foso\u002F9780198538493.001.0001",{"id":26,"text":1045,"url":26,"identifiers":1046},"MacKay DJC: A practical Bayesian Framework for backpropagation networks. Neural Computation. 1992, 4 (3): 448-472. 10.1162\u002Fneco.1992.4.3.448",{"doi":1047},"10.1162\u002Fneco.1992.4.3.448",{"id":26,"text":1049,"url":26,"identifiers":1050},"Riedmiller M: Advanced Supervised Learning in Multi-layer Perceptrons – From Backpropagation to Adaptive Learning Algorithms. Int Journal of Computer Standards and Interfaces. 1994, 16: 265-278. 10.1016\u002F0920-5489(94)90017-5. [Special Issue on Neural Networks]",{"doi":1051},"10.1016\u002F0920-5489(94)90017-5",false,{"id":1054,"createTime":1055,"updateTime":1056,"relativeEntities":1057,"slug":1058,"properties":1059,"entityType":769,"verifyStatus":25,"verifyTime":1055,"verifyNote":771,"syncStatus":28,"languages":1077,"translateLanguages":1078,"viewCount":36,"primaryUrl":1079,"fullTextUrl":26,"authors":1080,"publicationType":948,"publisherRelationship":1150,"citationCount":1175,"citationInfo":1176,"publishDate":1178,"publishYear":1179,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1180,"isForceReanalyzing":1052},"8d5d0c65-117a-493e-8b69-534a2f902391","2024-10-12T10:13:41.230+00:00","2025-02-06T12:20:43.251+00:00",[],"Identification-and-validation-of-reference-genes-for-quantitative-RT-PCR-normalization-in-wheat",{"mag":1060,"keywords":1062,"pmc":1063,"openalex":1065,"abstract":1067,"title":1070,"pm":1073,"doi":1075},{"VOID":1061},"2120099260",{"VI":754},{"VOID":1064},"2667184",{"VOID":1066},"W2120099260",{"EN":1068,"VI":1069},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Usually the reference genes used in gene expression analysis have been chosen for their known or suspected housekeeping roles, however the variation observed in most of them hinders their effective use. The assessed lack of validated reference genes emphasizes the importance of a systematic study for their identification. For selecting candidate reference genes we have developed a simple \u003Cjats:italic>in silico\u003C\u002Fjats:italic> method based on the data publicly available in the wheat databases Unigene and TIGR.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>The expression stability of 32 genes was assessed by qRT-PCR using a set of cDNAs from 24 different plant samples, which included different tissues, developmental stages and temperature stresses. The selected sequences included 12 well-known HKGs representing different functional classes and 20 genes novel with reference to the normalization issue. The expression stability of the 32 candidate genes was tested by the computer programs geNorm and NormFinder using five different data-sets. Some discrepancies were detected in the ranking of the candidate reference genes, but there was substantial agreement between the groups of genes with the most and least stable expression. Three new identified reference genes appear more effective than the well-known and frequently used HKGs to normalize gene expression in wheat. Finally, the expression study of a gene encoding a PDI-like protein showed that its correct evaluation relies on the adoption of suitable normalization genes and can be negatively affected by the use of traditional HKGs with unstable expression, such as actin and α-tubulin.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>The present research represents the first wide screening aimed to the identification of reference genes and of the corresponding primer pairs specifically designed for gene expression studies in wheat, in particular for qRT-PCR analyses. Several of the new identified reference genes outperformed the traditional HKGs in terms of expression stability under all the tested conditions. The new reference genes will enable more accurate normalization and quantification of gene expression in wheat and will be helpful for designing primer pairs targeting orthologous genes in other plant species.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Đặt vấn đề\u003C\u002Fjats:title>\n            \u003Cjats:p>Các gen tham chiếu thường được sử dụng trong phân tích biểu hiện gen thường đã được chọn vì vai trò được biết đến hoặc nghi ngờ của chúng trong chức năng housekeeping, tuy nhiên sự biến động quan sát thấy ở hầu hết chúng cản trở việc sử dụng hiệu quả của chúng. Thiếu hụt các gen tham chiếu đã được xác thực chỉ rõ tầm quan trọng của một nghiên cứu hệ thống nhằm xác định chúng. Để chọn các ứng viên gen tham chiếu, chúng tôi đã phát triển một phương pháp \u003Cjats:italic>in silico\u003C\u002Fjats:italic> đơn giản dựa trên dữ liệu công khai có sẵn trong các cơ sở dữ liệu lúa mì Unigene và TIGR.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Sự ổn định biểu hiện của 32 gen đã được đánh giá bằng qRT-PCR sử dụng một bộ cDNA từ 24 mẫu thực vật khác nhau, bao gồm các mô, giai đoạn phát triển khác nhau và các điều kiện stress nhiệt. Các trình tự được chọn bao gồm 12 gen HKG nổi tiếng đại diện cho các lớp chức năng khác nhau và 20 gen mới có liên quan đến vấn đề chuẩn hóa. Sự ổn định biểu hiện của 32 gen ứng viên đã được thử nghiệm thông qua các chương trình máy tính geNorm và NormFinder sử dụng năm bộ dữ liệu khác nhau. Một số sự khác biệt đã được phát hiện trong việc xếp hạng các gen tham chiếu ứng viên, nhưng có sự đồng thuận đáng kể giữa các nhóm gen với biểu hiện ổn định nhất và ít ổn định nhất. Ba gen tham chiếu mới được xác định dường như hiệu quả hơn so với các gen housekeeping nổi tiếng và được sử dụng phổ biến để chuẩn hóa biểu hiện gen trong lúa mì. Cuối cùng, nghiên cứu biểu hiện của một gen mã hóa protein PDI-like cho thấy rằng việc đánh giá chính xác của nó phụ thuộc vào việc áp dụng các gen chuẩn hóa phù hợp và có thể bị ảnh hưởng tiêu cực bởi việc sử dụng các gen HKG truyền thống với biểu hiện không ổn định, chẳng hạn như actin và α-tubulin.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Nghiên cứu hiện tại đại diện cho lần sàng lọc rộng đầu tiên nhằm xác định các gen tham chiếu và các cặp mồi tương ứng được thiết kế đặc biệt cho các nghiên cứu biểu hiện gen trong lúa mì, đặc biệt là cho các phân tích qRT-PCR. Nhiều gen tham chiếu mới được xác định vượt trội hơn các gen HKG truyền thống về mặt ổn định biểu hiện trong tất cả các điều kiện đã thử nghiệm. Các gen tham chiếu mới sẽ cho phép chuẩn hóa và định lượng chính xác hơn về biểu hiện gen trong lúa mì và sẽ hữu ích cho việc thiết kế các cặp mồi nhắm vào các gen cùng nguồn gốc ở các loài thực vật khác.",{"EN":1071,"VI":1072},"Identification and validation of reference genes for quantitative RT-PCR normalization in wheat","Xác định và xác thực các gen tham chiếu cho quá trình chuẩn hóa RT-PCR định lượng trong lúa mì",{"VOID":1074},"19232096",{"VOID":1076},"10.1186\u002F1471-2199-10-11",[102],[101],"https:\u002F\u002Fbmcmolbiol.biomedcentral.com\u002Farticles\u002F10.1186\u002F1471-2199-10-11",[1081,1101,1118,1133],{"id":1082,"sortIndex":114,"researcher":26,"roles":1083,"affiliations":1084,"properties":1096},"52412b5f-e040-4d9f-8324-bc510e299874",[],[1085],{"id":1086,"sortIndex":36,"affiliation":1087,"properties":26},"1e52899d-a963-4830-90e9-e656d4437538",{"id":1088,"createTime":1089,"updateTime":1090,"relativeEntities":1091,"slug":1092,"properties":1093,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"5aafea87-da8b-4223-96c7-8b8dc60d1ab9","2023-12-20T08:42:17.298+00:00","2024-10-12T10:13:41.245+00:00",[],"Dipartimento-di-Agrobiologia-ed-Agrochimica-Universit%C3%A0-della-Tuscia-Via-S-Camillo-De-Lellis-01100-Viterbo-Italy",{"title":1094},{"VI":1095},"Dipartimento di Agrobiologia ed Agrochimica, Università della Tuscia, Via S. 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Bustin",{"id":1591,"sortIndex":59,"researcher":26,"roles":1592,"affiliations":1593,"properties":1602},"52b245ef-a9c7-4752-ae18-3274a4dec08a",[],[1594],{"id":26,"sortIndex":36,"affiliation":1595,"properties":26},{"id":1596,"createTime":1597,"updateTime":1597,"relativeEntities":1598,"slug":26,"properties":1599,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"54365d18-ebf3-4221-962a-55f94d40cd0e","2024-01-27T02:39:00.373+00:00",[],{"title":1600},{"VI":1601},"Department of Clinical Research, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland",{"openalex":1603,"title":1605},{"VOID":1604},"A5041438085",{"EN":1606},"Rolf Jaggi",{"url":26,"publisher":1608,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1609,"slug":663,"properties":1610,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1613,"manageAffiliations":1614,"indexDatabases":1615,"url":26,"thumbnailPath":26,"statistic":1623,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"eissn":1611,"title":1612},{"VOID":666},{"EN":668},[],[],[1616],{"id":691,"indexDatabase":1617,"url":704,"indexYears":705,"academicFieldIds":1622,"indexDatabaseRanking":708},{"id":693,"createTime":694,"updateTime":695,"relativeEntities":1618,"label":1619,"description":1620,"key":701,"publicationTags":1621,"standard":26},[],{"EN":698,"VI":698},{"EN":698,"VI":700},[703],[707],{"impactFactor":36,"impactFactorByYear":1624,"i10Index":713,"i10IndexLast5Year":114,"totalPublication":714,"totalPublicationByYear":1625,"totalCitation":717,"totalCitationByYear":1626,"totalCitationPerPublication":726,"totalCitationPerPublicationByYear":1627,"hindexLast5Year":168,"hindex":168},{"2012":711,"2013":645,"2014":290,"2015":642,"2016":642,"2017":128,"2018":151,"2019":712,"2020":270,"2021":522},{"2000":115,"2001":50,"2002":53,"2003":50,"2004":298,"2005":51,"2006":125,"2007":245,"2008":716,"2009":716,"2010":142,"2011":517,"2012":238,"2013":239,"2014":516,"2015":51,"2016":356,"2017":124,"2018":53,"2019":516},{"2005":532,"2006":719,"2007":720,"2008":721,"2009":722,"2010":723,"2011":724,"2012":240,"2013":347,"2014":725,"2015":249,"2016":50,"2017":401,"2018":250,"2019":402},{"2005":728,"2006":729,"2007":730,"2008":731,"2009":732,"2010":733,"2011":52,"2012":734,"2013":111,"2014":735,"2015":736,"2016":737,"2017":738,"2018":135,"2019":739},582,{"total":1628,"publishYear":26,"statisticByYear":1630},{"2012":287,"2013":45,"2014":1631,"2015":286,"2016":608,"2017":204,"2018":539,"2019":204,"2020":125,"2021":287,"2022":204,"2023":255,"2024":53},55,"2010-01-01",2010,[],{"id":1636,"createTime":1637,"updateTime":1638,"relativeEntities":1639,"slug":1640,"properties":1641,"entityType":769,"verifyStatus":25,"verifyTime":1659,"verifyNote":771,"syncStatus":28,"languages":1660,"translateLanguages":1661,"viewCount":36,"primaryUrl":1662,"fullTextUrl":26,"authors":1663,"publicationType":948,"publisherRelationship":1751,"citationCount":1775,"citationInfo":1776,"publishDate":1178,"publishYear":1179,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1778,"isForceReanalyzing":1052},"29db2f55-e66a-4a42-88b5-3a5b9b1c47f7","2024-04-19T07:33:56.717+00:00","2025-02-06T12:21:44.981+00:00",[],"Selection-of-reliable-reference-genes-for-gene-expression-studies-in-peach-using-real-time-PCR",{"mag":1642,"keywords":1644,"pmc":1645,"openalex":1647,"abstract":1649,"title":1652,"pm":1655,"doi":1657},{"VOID":1643},"1991814173",{"VI":754},{"VOID":1646},"3224724",{"VOID":1648},"W1991814173",{"EN":1650,"VI":1651},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>RT-qPCR is a preferred method for rapid and reliable quantification of gene expression studies. Appropriate application of RT-qPCR in such studies requires the use of reference gene(s) as an internal control to normalize mRNA levels between different samples for an exact comparison of gene expression level. However, recent studies have shown that no single reference gene is universal for all experiments. Thus, the identification of high quality reference gene(s) is of paramount importance for the interpretation of data generated by RT-qPCR. Only a few studies on reference genes have been done in plants and none in peach \u003Cjats:italic>(Prunus persica\u003C\u002Fjats:italic> L. Batsch). Therefore, the present study was conducted to identify suitable reference gene(s) for normalization of gene expression in peach.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>In this work, eleven reference genes were investigated in different peach samples using RT-qPCR with SYBR green. These genes are: actin 2\u002F7 (\u003Cjats:italic>ACT\u003C\u002Fjats:italic>), cyclophilin (\u003Cjats:italic>CYP2\u003C\u002Fjats:italic>), RNA polymerase II (\u003Cjats:italic>RP II\u003C\u002Fjats:italic>), phospholipase A2 (\u003Cjats:italic>PLA2\u003C\u002Fjats:italic>), ribosomal protein L13 (\u003Cjats:italic>RPL13\u003C\u002Fjats:italic>), glyceraldehyde-3-phosphate dehydrogenase (\u003Cjats:italic>GAPDH\u003C\u002Fjats:italic>), 18S ribosomal RNA (\u003Cjats:italic>18S rRNA\u003C\u002Fjats:italic>), tubblin beta (\u003Cjats:italic>TUB\u003C\u002Fjats:italic>), tubblin alpha (\u003Cjats:italic>TUA\u003C\u002Fjats:italic>), translation elongation factor 2 (\u003Cjats:italic>TEF2\u003C\u002Fjats:italic>) and ubiquitin 10 (\u003Cjats:italic>UBQ10\u003C\u002Fjats:italic>). All eleven reference genes displayed a wide range of C\u003Cjats:sub>q\u003C\u002Fjats:sub> values in all samples, indicating that they expressed variably. The stability of these genes except for \u003Cjats:italic>RPL13\u003C\u002Fjats:italic> was determined by three different descriptive statistics, geNorm, NormFinder and BestKeeper, which produced highly comparable results.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>Our study demonstrates that expression stability varied greatly between genes studied in peach. Based on the results from geNorm, NormFinder and BestKeeper analyses, for all the sample pools analyzed, \u003Cjats:italic>TEF2\u003C\u002Fjats:italic>, \u003Cjats:italic>UBQ10\u003C\u002Fjats:italic> and \u003Cjats:italic>RP II\u003C\u002Fjats:italic> were found to be the most suitable reference genes with a very high statistical reliability, and \u003Cjats:italic>TEF2\u003C\u002Fjats:italic> and \u003Cjats:italic>RP II\u003C\u002Fjats:italic> for the other sample series, while \u003Cjats:italic>18S rRNA\u003C\u002Fjats:italic>, \u003Cjats:italic>RPL13\u003C\u002Fjats:italic> and \u003Cjats:italic>PLA2\u003C\u002Fjats:italic> were unsuitable as internal controls. \u003Cjats:italic>GAPDH\u003C\u002Fjats:italic> and \u003Cjats:italic>ACT\u003C\u002Fjats:italic> also performed poorly and were less stable in our analysis. To achieve accurate comparison of levels of gene expression, two or more reference genes must be used for data normalization. The combinations of \u003Cjats:italic>TEF2\u003C\u002Fjats:italic>\u002F\u003Cjats:italic>UBQ10\u002FRP II\u003C\u002Fjats:italic> and \u003Cjats:italic>TEF2\u002FRP II\u003C\u002Fjats:italic> were suggested for use in all samples and subsets, respectively.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Nền tảng\u003C\u002Fjats:title>\n            \u003Cjats:p>RT-qPCR là phương pháp được ưu tiên để định lượng nhanh chóng và đáng tin cậy trong các nghiên cứu về biểu hiện gen. Việc áp dụng thích hợp RT-qPCR trong các nghiên cứu như vậy yêu cầu sử dụng các gen tham chiếu như một chất đối chứng nội bộ để chuẩn hóa nồng độ mRNA giữa các mẫu khác nhau nhằm so sánh chính xác mức độ biểu hiện gen. Tuy nhiên, các nghiên cứu gần đây đã chỉ ra rằng không có gen tham chiếu đơn nhất nào được công nhận cho tất cả các thí nghiệm. Do đó, việc xác định các gen tham chiếu chất lượng cao là rất quan trọng cho việc phân tích dữ liệu từ RT-qPCR. Chỉ có một vài nghiên cứu về các gen tham chiếu đã được thực hiện trên thực vật và không có nghiên cứu nào trên cây đào \u003Cjats:italic>(Prunus persica\u003C\u002Fjats:italic> L. Batsch). Vì vậy, nghiên cứu hiện tại được tiến hành để xác định các gen tham chiếu phù hợp cho việc chuẩn hóa biểu hiện gen ở cây đào.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Trong nghiên cứu này, mười một gen tham chiếu đã được kiểm tra trên các mẫu đào khác nhau sử dụng RT-qPCR với SYBR green. Các gen này bao gồm: actin 2\u002F7 (\u003Cjats:italic>ACT\u003C\u002Fjats:italic>), cyclophilin (\u003Cjats:italic>CYP2\u003C\u002Fjats:italic>), RNA polymerase II (\u003Cjats:italic>RP II\u003C\u002Fjats:italic>), phospholipase A2 (\u003Cjats:italic>PLA2\u003C\u002Fjats:italic>), protein ribosome L13 (\u003Cjats:italic>RPL13\u003C\u002Fjats:italic>), glyceraldehyde-3-phosphate dehydrogenase (\u003Cjats:italic>GAPDH\u003C\u002Fjats:italic>), RNA ribosome 18S (\u003Cjats:italic>18S rRNA\u003C\u002Fjats:italic>), tubblin beta (\u003Cjats:italic>TUB\u003C\u002Fjats:italic>), tubblin alpha (\u003Cjats:italic>TUA\u003C\u002Fjats:italic>), yếu tố kéo dài dịch mã 2 (\u003Cjats:italic>TEF2\u003C\u002Fjats:italic>) và ubiquitin 10 (\u003Cjats:italic>UBQ10\u003C\u002Fjats:italic>). Tất cả mười một gen tham chiếu đều có giá trị C\u003Cjats:sub>q\u003C\u002Fjats:sub> rất đa dạng trong tất cả các mẫu, cho thấy rằng chúng được biểu hiện khác nhau. Độ ổn định của các gen này, ngoại trừ \u003Cjats:italic>RPL13\u003C\u002Fjats:italic>, đã được xác định bằng ba thống kê mô tả khác nhau, geNorm, NormFinder và BestKeeper, cho ra các kết quả có sự so sánh cao.",{"EN":1653,"VI":1654},"Selection of reliable reference genes for gene expression studies in peach using real-time PCR","Lựa chọn các gen tham chiếu đáng tin cậy cho nghiên cứu biểu hiện gen ở đào bằng phương pháp PCR thời gian thực",{"VOID":1656},"19619301",{"VOID":1658},"10.1186\u002F1471-2199-10-71","2024-12-14T17:11:39.620+00:00",[102],[101],"https:\u002F\u002Fbmcmolbiol.biomedcentral.com\u002Farticles\u002F10.1186\u002F1471-2199-10-71",[1664,1685,1702,1717,1734],{"id":1665,"sortIndex":111,"researcher":26,"roles":1666,"affiliations":1667,"properties":1678},"47384314-2bde-4f38-bc30-9889ca9f248b",[],[1668],{"id":1669,"sortIndex":36,"affiliation":1670,"properties":26},"e57674c2-d7d2-464d-9d90-337150e3385c",{"id":1671,"createTime":1672,"updateTime":1672,"relativeEntities":1673,"slug":1674,"properties":1675,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2d395514-efc2-43df-a50f-fcb0634922f3","2024-04-19T07:33:56.824+00:00",[],"College-of-Horticulture-Nanjing-Agricultural-University-1-Tongwei-Road-Weigang-Nanjing-210095-PR-China",{"title":1676},{"EN":1677},"College of Horticulture, Nanjing Agricultural University, 1 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Zhou",{"url":26,"publisher":1752,"properties":1772},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1753,"slug":663,"properties":1754,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1757,"manageAffiliations":1758,"indexDatabases":1759,"url":26,"thumbnailPath":26,"statistic":1767,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"eissn":1755,"title":1756},{"VOID":666},{"EN":668},[],[],[1760],{"id":691,"indexDatabase":1761,"url":704,"indexYears":705,"academicFieldIds":1766,"indexDatabaseRanking":708},{"id":693,"createTime":694,"updateTime":695,"relativeEntities":1762,"label":1763,"description":1764,"key":701,"publicationTags":1765,"standard":26},[],{"EN":698,"VI":698},{"EN":698,"VI":700},[703],[707],{"impactFactor":36,"impactFactorByYear":1768,"i10Index":713,"i10IndexLast5Year":114,"totalPublication":714,"totalPublicationByYear":1769,"totalCitation":717,"totalCitationByYear":1770,"totalCitationPerPublication":726,"totalCitationPerPublicationByYear":1771,"hindexLast5Year":168,"hindex":168},{"2012":711,"2013":645,"2014":290,"2015":642,"2016":642,"2017":128,"2018":151,"2019":712,"2020":270,"2021":522},{"2000":115,"2001":50,"2002":53,"2003":50,"2004":298,"2005":51,"2006":125,"2007":245,"2008":716,"2009":716,"2010":142,"2011":517,"2012":238,"2013":239,"2014":516,"2015":51,"2016":356,"2017":124,"2018":53,"2019":516},{"2005":532,"2006":719,"2007":720,"2008":721,"2009":722,"2010":723,"2011":724,"2012":240,"2013":347,"2014":725,"2015":249,"2016":50,"2017":401,"2018":250,"2019":402},{"2005":728,"2006":729,"2007":730,"2008":731,"2009":732,"2010":733,"2011":52,"2012":734,"2013":111,"2014":735,"2015":736,"2016":737,"2017":738,"2018":135,"2019":739},{"volume":1773,"issue":1774},{"VOID":1173},{"VOID":974},571,{"total":1775,"publishYear":26,"statisticByYear":1777},{"2012":125,"2013":159,"2014":257,"2015":517,"2016":29,"2017":244,"2018":402,"2019":259,"2020":284,"2021":539,"2022":398,"2023":286,"2024":103},[1779,1782,1785,1789,1792,1796,1799,1803,1807,1810,1814,1817,1821,1824,1828,1832,1836,1840,1843,1847,1851,1854,1858,1861,1864,1867,1871,1875,1879,1882,1886,1889,1893,1896,1899,1902,1906,1909,1913,1917,1921,1924,1927,1930,1934,1937,1941,1945,1949,1953,1957,1961,1965,1968,1972,1975,1979,1982,1986,1990,1994,1998,2002,2005,2008,2012,2016,2020,2024,2027],{"id":26,"text":1780,"url":26,"identifiers":1781},"Ginzinger DG: Gene quantification using real-time quantitative PCR: An emerging technology hits the mainstream. Exp Hematol. 2002, 30 (6): 503-512.",{"doi":1200},{"id":26,"text":1783,"url":26,"identifiers":1784},"Bustin SA: Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol. 2002, 29 (1): 23-39.",{"doi":1196},{"id":26,"text":1786,"url":26,"identifiers":1787},"Garson JA, Grant PR, Ayliffe U, Ferns RB, Tedder RS: Real-time PCR quantitation of hepatitis B virus DNA using automated sample preparation and murine cytomegalovirus internal control. J Virol Methods. 2005, 126 (1–2): 207-213.",{"doi":1788},"10.1016\u002Fj.jviromet.2005.03.001",{"id":26,"text":1790,"url":26,"identifiers":1791},"Huggett J, Dheda K, Bustin S, Zumla A: Real-time RT-PCR normalisation; strategies and considerations. Genes Immun. 2005, 6 (4): 279-284.",{"doi":1204},{"id":26,"text":1793,"url":26,"identifiers":1794},"Schmittgen TD, Zakrajsek BA: Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR. 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Methods. 2001, 25 (4): 402-408.",{"doi":2023},"10.1006\u002Fmeth.2001.1262",{"id":26,"text":2025,"url":26,"identifiers":2026},"NormFinder Software. http:\u002F\u002Fwww.mdl.dk\u002Fpublicationsnormfinder.htm",{},{"id":26,"text":2028,"url":26,"identifiers":2029},"BestKeeper Software. http:\u002F\u002Fwww.gene-quantification.de\u002Fbestkeeper.html",{},{"id":2031,"createTime":2032,"updateTime":2033,"relativeEntities":2034,"slug":2035,"properties":2036,"entityType":769,"verifyStatus":25,"verifyTime":2055,"verifyNote":771,"syncStatus":28,"languages":2056,"translateLanguages":2057,"viewCount":36,"primaryUrl":2058,"fullTextUrl":26,"authors":2059,"publicationType":948,"publisherRelationship":2227,"citationCount":2251,"citationInfo":2252,"publishDate":1178,"publishYear":1179,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2254,"isForceReanalyzing":1052},"8d82568e-178d-45c1-8ab8-82d936f66d80","2024-04-19T15:48:16.826+00:00","2024-12-30T03:13:27.350+00:00",[],"Validation-of-reference-genes-for-quantitative-expression-analysis-by-real-time-RT-PCR-in-Saccharomyces-cerevisiae",{"mag":2037,"keywords":2039,"pmc":2041,"openalex":2043,"abstract":2045,"title":2048,"pm":2051,"doi":2053},{"VOID":2038},"2156780012",{"VI":2040},"RT-PCR, gene biểu hiện, thực vật, Saccharomyces cerevisiae, chuẩn hóa gen, gen tham chiếu",{"VOID":2042},"2776018",{"VOID":2044},"W2156780012",{"EN":2046,"VI":2047},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Real-time RT-PCR is the recommended method for quantitative gene expression analysis. A compulsory step is the selection of good reference genes for normalization. A few genes often referred to as HouseKeeping Genes (HSK), such as \u003Cjats:italic>ACT1\u003C\u002Fjats:italic>, \u003Cjats:italic>RDN18\u003C\u002Fjats:italic> or \u003Cjats:italic>PDA1\u003C\u002Fjats:italic> are among the most commonly used, as their expression is assumed to remain unchanged over a wide range of conditions. Since this assumption is very unlikely, a geometric averaging of multiple, carefully selected internal control genes is now strongly recommended for normalization to avoid this problem of expression variation of single reference genes. The aim of this work was to search for a set of reference genes for reliable gene expression analysis in \u003Cjats:italic>Saccharomyces cerevisiae\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>From public microarray datasets, we selected potential reference genes whose expression remained apparently invariable during long-term growth on glucose. Using the algorithm geNorm, \u003Cjats:italic>ALG9\u003C\u002Fjats:italic>, \u003Cjats:italic>TAF10\u003C\u002Fjats:italic>, \u003Cjats:italic>TFC1\u003C\u002Fjats:italic> and \u003Cjats:italic>UBC6\u003C\u002Fjats:italic> turned out to be genes whose expression remained stable, independent of the growth conditions and the strain backgrounds tested in this study. We then showed that the geometric averaging of any subset of three genes among the six most stable genes resulted in very similar normalized data, which contrasted with inconsistent results among various biological samples when the normalization was performed with \u003Cjats:italic>ACT1\u003C\u002Fjats:italic>. Normalization with multiple selected genes was therefore applied to transcriptional analysis of genes involved in glycogen metabolism. We determined an induction ratio of 100-fold for \u003Cjats:italic>GPH1\u003C\u002Fjats:italic> and 20-fold for \u003Cjats:italic>GSY2\u003C\u002Fjats:italic> between the exponential phase and the diauxic shift on glucose. There was no induction of these two genes at this transition phase on galactose, although in both cases, the kinetics of glycogen accumulation was similar. In contrast, \u003Cjats:italic>SGA1\u003C\u002Fjats:italic> expression was independent of the carbon source and increased by 3-fold in stationary phase.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>In this work, we provided a set of genes that are suitable reference genes for quantitative gene expression analysis by real-time RT-PCR in yeast biological samples covering a large panel of physiological states. In contrast, we invalidated and discourage the use of \u003Cjats:italic>ACT1\u003C\u002Fjats:italic> as well as other commonly used reference genes (\u003Cjats:italic>PDA1, TDH3, RDN18\u003C\u002Fjats:italic>, etc) as internal controls for quantitative gene expression analysis in yeast.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Nền tảng\u003C\u002Fjats:title>\n            \u003Cjats:p>RT-PCR thời gian thực là phương pháp được khuyến nghị cho phân tích biểu hiện gen định lượng. Một bước bắt buộc là chọn các gen tham chiếu tốt để chuẩn hóa. Một vài gen thường được gọi là gen HouseKeeping (HSK), chẳng hạn như \u003Cjats:italic>ACT1\u003C\u002Fjats:italic>, \u003Cjats:italic>RDN18\u003C\u002Fjats:italic> hoặc \u003Cjats:italic>PDA1\u003C\u002Fjats:italic>, là một trong những gen được sử dụng phổ biến nhất, vì có giả định rằng biểu hiện của chúng không thay đổi nhiều trong một loạt các điều kiện. Vì giả định này rất khó xảy ra, việc trung bình hình học của nhiều gen kiểm soát nội bộ được chọn cẩn thận hiện được khuyến nghị mạnh mẽ cho việc chuẩn hóa nhằm tránh vấn đề biến thiên biểu hiện của các gen tham chiếu đơn lẻ. Mục tiêu của công việc này là tìm kiếm một tập hợp các gen tham chiếu cho phân tích biểu hiện gen chính xác trong \u003Cjats:italic>Saccharomyces cerevisiae\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Từ các tập dữ liệu vi điều hòa công khai, chúng tôi đã chọn các gen tham chiếu tiềm năng mà biểu hiện của chúng rõ ràng vẫn không thay đổi trong quá trình phát triển lâu dài trên glucose. Sử dụng thuật toán geNorm, \u003Cjats:italic>ALG9\u003C\u002Fjats:italic>, \u003Cjats:italic>TAF10\u003C\u002Fjats:italic>, \u003Cjats:italic>TFC1\u003C\u002Fjats:italic> và \u003Cjats:italic>UBC6\u003C\u002Fjats:italic> đã cho thấy là những gen có biểu hiện ổn định, không phụ thuộc vào các điều kiện phát triển và nền tảng chủng đã thử nghiệm trong nghiên cứu này. Chúng tôi sau đó đã chỉ ra rằng trung bình hình học của bất kỳ tập hợp nào gồm ba gen trong số sáu gen ổn định nhất cũng cho kết quả dữ liệu chuẩn hóa rất tương đồng, điều này khác biệt với các kết quả không nhất quán giữa các mẫu sinh học khác nhau khi chuẩn hóa được thực hiện với \u003Cjats:italic>ACT1\u003C\u002Fjats:italic>. Do đó, việc chuẩn hóa với nhiều gen được chọn đã được áp dụng cho phân tích phiên mã của các gen liên quan đến chuyển hóa glycogen. Chúng tôi đã xác định tỷ lệ cảm ứng là 100 lần cho \u003Cjats:italic>GPH1\u003C\u002Fjats:italic> và 20 lần cho \u003Cjats:italic>GSY2\u003C\u002Fjats:italic> giữa pha số mũ và chuyển tiếp diauxic trên glucose. Không có sự cảm ứng của hai gen này ở pha chuyển tiếp trên galactose, mặc dù trong cả hai trường hợp, động học tích lũy glycogen là tương tự nhau. Ngược lại, biểu hiện của \u003Cjats:italic>SGA1\u003C\u002Fjats:italic> không phụ thuộc vào nguồn carbon và tăng gấp 3 lần ở pha dừng lại.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Trong công việc này, chúng tôi đã cung cấp một tập hợp các gen phù hợp làm gen tham chiếu cho phân tích biểu hiện gen định lượng bằng RT-PCR thời gian thực trên các mẫu sinh học men bao gồm một bảng lớn các trạng thái sinh lý. Ngược lại, chúng tôi đã không xác nhận và không khuyến khích việc sử dụng \u003Cjats:italic>ACT1\u003C\u002Fjats:italic> cũng như các gen tham chiếu thường sử dụng khác (\u003Cjats:italic>PDA1, TDH3, RDN18\u003C\u002Fjats:italic>, v.v.) làm các kiểm soát nội bộ cho phân tích biểu hiện gen định lượng trong men.",{"EN":2049,"VI":2050},"Validation of reference genes for quantitative expression analysis by real-time RT-PCR in Saccharomyces cerevisiae","Xác thực các gen tham chiếu cho phân tích biểu hiện định lượng bằng phản ứng chuỗi polymerase thời gian thực (RT-PCR) trong Saccharomyces 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Clin Cancer Res. 2007, 13 (21): 6284-6292. 10.1158\u002F1078-0432.CCR-07-0525",{"doi":3755},"10.1158\u002F1078-0432.CCR-07-0525",{"id":26,"text":3757,"url":26,"identifiers":3758},"Bozinov O, Kohler S, Samans B, Benes L, Miller D, Ritter M, Sure U, Bertalanffy H: Candidate genes for the progression of malignant gliomas identified by microarray analysis. Neurosurg Rev. 2008, 31 (1): 83-89. discussion 89–90 10.1007\u002Fs10143-007-0107-3",{"doi":3759},"10.1007\u002Fs10143-007-0107-3",{"id":26,"text":3761,"url":26,"identifiers":3762},"Scrideli CA, Carlotti CG, Okamoto OK, Andrade VS, Cortez MA, Motta FJ, Lucio-Eterovic AK, Neder L, Rosemberg S, Oba-Shinjo SM, et al: Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR. J Neurooncol. 2008, 88 (3): 281-291. 10.1007\u002Fs11060-008-9579-4",{"doi":3763},"10.1007\u002Fs11060-008-9579-4",{"id":26,"text":1238,"url":26,"identifiers":3765},{"doi":1240},{"id":26,"text":3767,"url":26,"identifiers":3768},"Haller F, Kulle B, Schwager S, Gunawan B, von Heydebreck A, Sultmann H, Fuzesi L: Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization. Anal Biochem. 2004, 335 (1): 1-9. 10.1016\u002Fj.ab.2004.08.024",{"doi":1403},{"id":26,"text":3770,"url":26,"identifiers":3771},"Noor A, Windpassinger C, Patel M, Stachowiak B, Mikhailov A, Azam M, Irfan M, Siddiqui ZK, Naeem F, Paterson AD, et al: CC2D2A, encoding a coiled-coil and C2 domain protein, causes autosomal-recessive mental retardation with retinitis pigmentosa. Am J Hum Genet. 2008, 82 (4): 1011-1018. 10.1016\u002Fj.ajhg.2008.01.021",{"doi":3772},"10.1016\u002Fj.ajhg.2008.01.021",{"id":26,"text":3774,"url":26,"identifiers":3775},"Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006, 127 (3): 635-648. 10.1016\u002Fj.cell.2006.09.026",{"doi":3776},"10.1016\u002Fj.cell.2006.09.026",{"id":26,"text":3778,"url":26,"identifiers":3779},"Lefevre C, Bouadjar B, Karaduman A, Jobard F, Saker S, Ozguc M, Lathrop M, Prud'homme JF, Fischer J: Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis. Hum Mol Genet. 2004, 13 (20): 2473-2482. 10.1093\u002Fhmg\u002Fddh263",{"doi":3780},"10.1093\u002Fhmg\u002Fddh263",{"id":26,"text":3782,"url":26,"identifiers":3783},"Rui Y, Xu Z, Xiong B, Cao Y, Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, et al: A beta-catenin-independent dorsalization pathway activated by Axin\u002FJNK signaling and antagonized by aida. Dev Cell. 2007, 13 (2): 268-282. 10.1016\u002Fj.devcel.2007.07.006",{"doi":3784},"10.1016\u002Fj.devcel.2007.07.006",{"id":26,"text":3786,"url":26,"identifiers":3787},"Douglas J, Cilliers D, Coleman K, Tatton-Brown K, Barker K, Bernhard B, Burn J, Huson S, Josifova D, Lacombe D, et al: Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. Nat Genet. 2007, 39 (8): 963-965. 10.1038\u002Fng2083",{"doi":3788},"10.1038\u002Fng2083",{"id":26,"text":3790,"url":26,"identifiers":3791},"Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, et al: Complete sequencing and characterization of 21, 243 full-length human cDNAs. Nat Genet. 2004, 36 (1): 40-45. 10.1038\u002Fng1285",{"doi":3792},"10.1038\u002Fng1285",{"id":26,"text":3794,"url":26,"identifiers":3795},"Eilbracht J, Reichenzeller M, Hergt M, Schnolzer M, Heid H, Stohr M, Franke WW, Schmidt-Zachmann MS: NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. Mol Biol Cell. 2004, 15 (4): 1816-1832. 10.1091\u002Fmbc.E03-08-0623",{"doi":3796},"10.1091\u002Fmbc.E03-08-0623",{"id":26,"text":3798,"url":26,"identifiers":3799},"Kato T, Sato N, Hayama S, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y, Daigo Y: Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Cancer Res. 2007, 67 (18): 8544-8553. 10.1158\u002F0008-5472.CAN-07-1307",{"doi":3800},"10.1158\u002F0008-5472.CAN-07-1307",{"id":26,"text":3802,"url":26,"identifiers":3803},"Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W: The LIFEdb database in 2006. Nucleic Acids Res. 2006, D415-418. 34 Database",{"doi":3804},"10.1093\u002Fnar\u002Fgkj139",{"id":26,"text":3806,"url":26,"identifiers":3807},"Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, et al: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121-2127. 10.1101\u002Fgr.2596504",{"doi":3808},"10.1101\u002Fgr.2596504",{"id":26,"text":3810,"url":26,"identifiers":3811},"Ohl F, Jung M, Radonic A, Sachs M, Loening SA, Jung K: Identification and validation of suitable endogenous reference genes for gene expression studies of human bladder cancer. J Urol. 2006, 175 (5): 1915-1920. 10.1016\u002FS0022-5347(05)00919-5",{"doi":3812},"10.1016\u002FS0022-5347(05)00919-5",{"id":26,"text":3814,"url":26,"identifiers":3815},"Schmid H, Cohen CD, Henger A, Irrgang S, Schlondorff D, Kretzler M: Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies. Kidney Int. 2003, 64 (1): 356-360. 10.1046\u002Fj.1523-1755.2003.00074.x",{"doi":1427},{"id":26,"text":3817,"url":26,"identifiers":3818},"Solanas M, Moral R, Escrich E: Unsuitability of using ribosomal RNA as loading control for Northern blot analyses related to the imbalance between messenger and ribosomal RNA content in rat mammary tumors. Anal Biochem. 2001, 288 (1): 99-102. 10.1006\u002Fabio.2000.4889",{"doi":3819},"10.1006\u002Fabio.2000.4889",{"id":26,"text":3821,"url":26,"identifiers":3822},"Marie SK, Okamoto OK, Uno M, Hasegawa AP, Oba-Shinjo SM, Cohen T, Camargo AA, Kosoy A, Carlotti CG, Toledo S, et al: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. Int J Cancer. 2008, 122 (4): 807-815. 10.1002\u002Fijc.23189",{"doi":3823},"10.1002\u002Fijc.23189",{"id":26,"text":3825,"url":26,"identifiers":3826},"Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25 (4): 402-408. 10.1006\u002Fmeth.2001.1262",{"doi":2023},{"id":3828,"createTime":3829,"updateTime":3830,"relativeEntities":3831,"slug":3832,"properties":3833,"entityType":769,"verifyStatus":25,"verifyTime":3842,"verifyNote":771,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":3843,"fullTextUrl":26,"authors":3844,"publicationType":948,"publisherRelationship":3937,"citationCount":3962,"citationInfo":3963,"publishDate":3965,"publishYear":984,"citationAnalyzeStatus":28,"lastCitationAnalyze":3966,"indexDatabases":26,"openAccess":26,"references":3967,"isForceReanalyzing":1052},"9c35146d-4694-473d-8020-0e6f90ddd3cd","2023-12-07T14:03:22.896+00:00","2026-03-16T22:38:09.116+00:00",[],"Cloning-and-expression-analysis-of-two-distinct-HIF-alpha-isoforms-gcHIF-1alpha-and-gcHIF-4alpha-from-the-hypoxia-tolerant-grass-carp-Ctenopharyngodon-idellus",{"abstract":3834,"title":3836,"doi":3838,"gsPaper":3840},{"EN":3835},"Hypoxia-inducible factors (HIFs) are involved in adaptive and survival responses to hypoxic stress in mammals. In fish, very little is known about the functions of HIFs. We have cloned and characterized two distinct HIF-alpha cDNAs – gcHIF-1alpha and gcHIF-4alpha – from the hypoxia-tolerant grass carp. The deduced gcHIF-1alpha protein is highly similar to the HIF-1alphas (57–68%) from various vertebrate species, while gcHIF-4alpha is a novel isoform, and shows an equivalent degree of amino acid identity (41–47%) to the HIF-1alpha, HIF-2alpha and HIF-3alpha proteins so far described. Parsimony analysis indicated that gcHIF-4alpha is most closely related to the HIF-3alpha proteins. Northern blot analysis showed that mRNA levels of gcHIF-1alpha and gcHIF-4alpha differ substantially under normoxic and hypoxic conditions, while Western blot studies demonstrated that the endogenous protein levels for both gcHIF-1alpha and gcHIF-4alpha are similarly responsive to hypoxia. Our findings suggest that both gcHIF-1alpha and gcHIF-4alpha are differentially regulated at the transcriptional and translational levels. HRE-luciferase reporter assays show that both proteins function as transcription activators and play distinct roles in modulating the hypoxic response in grass carp. There are at least two distinct HIF-alpha isoforms – gcHIF-1alpha and gcHIF-4alpha – in the hypoxia-tolerant grass carp, which are differentially expressed and regulated in different fish organs in response to hypoxic stress. Overall, the results suggest that unique molecular mechanisms operate through these two HIF-alpha isoforms, which underpin the hypoxic response in the hypoxia-tolerant grass carp.",{"EN":3837},"Cloning and expression analysis of two distinct HIF-alpha isoforms – gcHIF-1alpha and gcHIF-4alpha – from the hypoxia-tolerant grass carp, Ctenopharyngodon idellus",{"VOID":3839},"10.1186\u002F1471-2199-7-15",{"VOID":3841},"[\"7511801855303691941\"]","2024-04-23T14:33:04.049+00:00","https:\u002F\u002Fbmcmolbiol.biomedcentral.com\u002Farticles\u002F10.1186\u002F1471-2199-7-15",[3845,3861,3884,3903,3917],{"id":3846,"sortIndex":36,"researcher":26,"roles":3847,"affiliations":3849,"properties":3858},"a0168c34-ff7f-4068-92f0-cf85b26a10b7",[3848],"AUTHOR",[3850],{"id":26,"sortIndex":36,"affiliation":3851,"properties":26},{"id":3852,"createTime":3853,"updateTime":3853,"relativeEntities":3854,"slug":26,"properties":3855,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"8518c108-19bd-453d-b3e6-5332199d2c52","2023-12-06T10:43:16.422+00:00",[],{"title":3856},{"VI":3857},"Department of Biology and Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong Special Administrative Region, People's Republic of China",{"title":3859},{"VI":3860},"Sheran HW Law",{"id":3862,"sortIndex":59,"researcher":26,"roles":3863,"affiliations":3864,"properties":3879},"1537560c-746d-43e4-8d3b-79657abf7454",[3848],[3865,3874],{"id":3866,"sortIndex":115,"affiliation":3867,"properties":26},"eb40da69-2a22-45dd-8008-2441fa58e0d7",{"id":3868,"createTime":3869,"updateTime":3869,"relativeEntities":3870,"slug":26,"properties":3871,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"57401023-35fb-4742-bb7b-e361309c0af8","2023-12-07T14:03:30.782+00:00",[],{"title":3872},{"VI":3873},"Centre for Coastal Pollution and Conservation, City University of Hong Kong, Kowloon Tong, Hong Kong Special Administrative Region, People's Republic of 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A, van der Groep P, Kemming D, Shvarts A, Semenza G, Meijer G, van de Wiel M, Belien J, van Diest P, van der Wall E: Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol. 2005, 206: 291-304. 10.1002\u002Fpath.1778","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fpath.1778",{"mag":3972,"openalex":3973,"pm":3974,"doi":3975},"2139576132","W2139576132","15906272","10.1002\u002Fpath.1778",{"id":3977,"text":3978,"url":3979,"identifiers":3980},"4c68646b-0035-4279-8000-0006b275d4fa","Wang G, Jiang B, Rue E, Semenza G: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. PNAS. 1995, 92: 5510-5514.","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":3981},"10.1007\u002Fs10440-022-00541-7",{"id":26,"text":3983,"url":3984,"identifiers":3985},"Wenger RH: Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 2002, 16: 1151-1162. 10.1096\u002Ffj.01-0944rev","http:\u002F\u002Fdx.doi.org\u002F10.1096\u002Ffj.01-0944rev",{"doi":3986},"10.1096\u002Ffj.01-0944rev",{"id":26,"text":3988,"url":26,"identifiers":3989},"Semenza G: Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol. 1999, 15: 551-578. 10.1146\u002Fannurev.cellbio.15.1.551",{"doi":3990},"10.1146\u002Fannurev.cellbio.15.1.551",{"id":26,"text":3992,"url":3993,"identifiers":3994},"Jiang B-H, Rue E, Wang GL, Roe R, Semenza GL: Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem. 1996, 271: 17771-17778. 10.1074\u002Fjbc.271.30.17771","https:\u002F\u002Fdoi.org\u002F10.1074\u002Fjbc.271.30.17771",{"mag":3995,"openalex":3996,"pm":3997,"doi":3998},"2046440184","W2046440184","8663540","10.1074\u002Fjbc.271.30.17771",{"id":26,"text":4000,"url":26,"identifiers":4001},"Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG: HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science. 2001, 292: 464-468.",{},{"id":26,"text":4003,"url":4004,"identifiers":4005},"Masson N, Willam C, Maxwell P, Pugh C, Ratcliffe P: Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. 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