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Research Signpost, Kerala, pp 51–65\nStraube N, Iglésias SP, Sellos DY et al (2010) Molecular phylogeny and node time estimation of bioluminescent lantern sharks (Elasmobranchii: Etmopteridae). Mol Phylogenet Evol 56:905–917. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjfb.12874\nStraube N, Kriwet J, Schliewen UK (2011) Cryptic diversity and species assignment of large lantern sharks of the Etmopterus spinax clade from the Southern Hemisphere (Squaliformes, Etmopteridae). Zool Scr 40:61–75. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1463-6409.2010.00455.x\nGubili C, Macleod K, Perry W et al (2016) Connectivity in the deep: phylogeography of the velvet belly lanternshark. Deep Sea Res Part Oceanogr Res Pap 115:233–239. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dsr.2016.07.002\nMoen FE, Svensen E (2004) Marine fish and invertebrates of Northern Europe. AquaPress, Essex\nCoelho R, Erzini K (2010) Depth distribution of the velvet belly, Etmopterus spinax. in relation to growth and reproductive cycle: the case study of a deep-water lantern shark with a wide-ranging critical habitat. Mar Biol Res 6:381–389. https:\u002F\u002Fdoi.org\u002F10.1080\u002F17451000802644706\nWeigmann S (2016) Annotated checklist of the living sharks, batoids and chimaeras (Chondrichthyes) of the world, with a focus on biogeographical diversity. J Fish Biol 88:837–1037. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjfb.12874\nCoelho R, Erzini K (2008) Life history of a wide-ranging deepwater lantern shark in the north-east Atlantic, Etmopterus spinax (Chondrichthyes: Etmopteridae), with implications for conservation. J Fish Biol 73:1419–1443. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1095-8649.2008.02021.x\nCoelho R, Rey J, de Sola LG et al (2010) Comparing Atlantic and Mediterranean populations of the velvet belly lanternshark, Etmopterus spinax, with comments on the efficiency of density-dependent compensatory mechanisms. Mar Biol Res 6:373–380. https:\u002F\u002Fdoi.org\u002F10.1080\u002F17451000903300885\nCoelho R, Alpizar-Jara R, Erzini K (2015) Demography of a deep-sea lantern shark (Etmopterus spinax) caught in trawl fisheries of the northeastern Atlantic: application of Leslie matrices with incorporated uncertainties. Deep Sea Res Part II Top Stud Oceanogr 115:64–72. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.dsr2.2014.01.012\nBeier S, Thiel T, Münch T et al (2017) MISA-web: a web server for microsatellite prediction. Bioinformatics 33:2583–2585. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fbioinformatics\u002Fbtx198\nKoressaar T, Remm M (2007) Enhancements and modifications of primer design program Primer3. Bioinformatics 23:1289–1291. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fbioinformatics\u002Fbtm091\nUntergasser A, Cutcutache I, Koressaar T et al (2012) Primer3—new capabilities and interfaces. Nucleic Acids Res 40:e115. https:\u002F\u002Fdoi.org\u002F10.1093\u002Fnar\u002Fgks596\nMeglécz E, Pech N, Gilles A et al (2014) QDD version 3.1: a user-friendly computer program for microsatellite selection and primer design revisited: experimental validation of variables determining genotyping success rate. Mol Ecol Resour 14:1302–1313. https:\u002F\u002Fdoi.org\u002F10.1111\u002F1755-0998.12271\nSchuelke M (2000) An economic method for the fluorescent labeling of PCR fragments. Nat Biotechnol 18:233–234. https:\u002F\u002Fdoi.org\u002F10.1038\u002F72708\nWright S (1931) Evolution in Mendelian populations. Genetics 16:97–159\nGoudet J (2001) FSTAT, a program to estimate and test gene diversities and fixation indices version 2.9.3.2, updated from Goudet 1995\nRaymond M, Rousset F (1995) GenePop: population genetics software for exact tests and ecumenism. J Hered 86:248–249. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1558-5646.1995.tb04456.x\nRousset F (2008) Genepop’007: a complete re-implementation of the genepop software for Windows and Linux. Mol Ecol Resour 8:103–106. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1471-8286.2007.01931.x\nBenjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B Methodol 57:289–300\nvan Oosterhout C, Hutchinson WF, Wills DP, Shipley P (2004) Micro-Checker: software for identifying and correcting genotyping errors in microsatellite data. Mol Ecol Notes 4:535–538. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1471-8286.2004.00684.x",{"EN":266},"Etmopterus spinax (Linnaeus, 1758) and Etmopterus molleri (Whitley, 1939) are two bioluminescent deep-sea sharks, usually caught in large numbers as bycatch by deep-water fisheries. Yet, no study has ever involved population status of these two species using genetic tools. In order to investigate population genetic structure, diversity and connectivity of these two lanternsharks, 29 and 19 microsatellite loci were isolated from E. spinax DNA library for E. spinax and E. molleri, respectively. These loci were tested on 32 E. spinax individuals from the North Sea and seven E. molleri from the East China Sea. The number of alleles per locus ranged from 2 to 13. The observed heterozygosity ranged from 0.031 to 0.839 for E. spinax and from 0.000 to 1.000 for E. molleri, while the expected heterozygosity ranged from 0.031 to 0.903 and from 0.143 to 0.821, respectively. Almost all loci (24 and 16, respectively) were at Hardy–Weinberg equilibrium for both species and no linkage disequilibrium among loci was detected. These loci represent useful tools to better understand the population structure of these two species. 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Curr Probl Pediatr Adolesc Health Care 39(4):97–140\nNaucke TJ, Lorentz S, Grünewald H-W (2006) Laboratory testing of the insect repellents IR3535® and DEET against Phlebotomus mascittii and P. duboscqi (Diptera: Psychodidae). Int J Med Microbiol 296:230–232\nBissinger BW, Roe RM (2010) Tick repellents: past, present, and future. Pestic Biochem Physiol 96(2):63–79\nStrickman D (2006) Older synthetic active ingredients and current additives. In: Insect repellents: principles, methods, and uses\nSandstrom MW, Kolpin DW, Thurman EM, Zaugg SD (2005) Widespread detection of N,N-diethyl-m-toluamide in US Streams: Comparison with concentrations of pesticides, personal care products, and other organic wastewater compounds. Environ Toxicol Chem 24(5):1029–1034\nFrances SP, Debboun M, Debboun M, Frances S, Strickman D (2007) User acceptability: public perceptions of insect repellents. In: Insect repellents: principles, methods, and uses, pp 397–404\nKatz TM, Miller JH, Hebert AA (2008) Insect repellents: historical perspectives and new developments. J Am Acad Dermatol 58(5):865–871\nBrown M, Hebert AA (1997) Insect repellents: an overview. J Am Acad Dermatol 36(2):243–249\nPuccetti G, Debboun M, Frances S, Strickman D (2006) IR3535 (ethyl butylacetylaminopropionate). In: Insect repellents: principles, methods, and uses\nCarroll SP (2008) Prolonged efficacy of IR3535 repellents against mosquitoes and blacklegged ticks in North America. J Med Entomol 45(4):706–714\nNentwig G (2003) Use of repellents as prophylactic agents. Parasitol Res 90(1):S40–S48\nDebboun M, Frances SP, Strickman D (2006) Insect repellents: principles, methods, and uses. CRC Press, Boca Raton\nvon Elert E, Preuss K, Fink P (2016) Infodisruption of inducible anti-predator defenses through commercial insect repellents? Environ Pollut 210:18–26\nKalaycı S, Demirci S, Sahin F (2014) Determination of antimicrobial properties of Picaridin and DEET against a broad range of microorganisms. World J Microbiol Biotechnol 30(2):407–411\nWayne P (2007) Clinical and laboratory standards institute. Performance standards for antimicrobial susceptibility testing\nHamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 11(7):714–719\nLivermore DM (2002) Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin Infect Dis 34(5):634–640\nBenz R, Hancock RE (1981) Properties of the large ion-permeable pores formed from protein F of Pseudomonas aeruginosa in lipid bilayer membranes. Biochim Biophys Acta (BBA) 646(2):298–308\nPoole K (2001) Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol 3(2):255–264\nEpstein HA (2012) Repelling insects with safe and effective alternatives to DEET. Skinmed 10(1):36–39\nPark SJ, Kim JE, Park MJ, Lee IS, Lee J, Lee J, Kim BH, Lee DK, Lee SP (2012) Repellent efficacy and safety evaluation of IR3535 derivative against Aedes albopictus, Culex pipiens pallens and Aedes togoi. Entomol Res 42(6):299–307\nNaucke T, Kröpke R, Benner G, Schulz J, Wittern K, Rose A, Kröckel U, Grünewald H (2007) Field evaluation of the efficacy of proprietary repellent formulations with IR3535® and Picaridin against Aedes aegypti. Parasitol Res 101(1):169–177\nStaub D, Debrunner M, Amsler L, Steffen R (2002) Effectiveness of a repellent containing DEET and EBAAP for preventing tick bites. Wilderness Environ Med 13(1):12–20\nFaulde MK, Albiez G, Nehring O (2010) Insecticidal, acaricidal and repellent effects of DEET-and IR3535-impregnated bed nets using a novel long-lasting polymer-coating technique. Parasitol Res 106(4):957–965",{"EN":390},"Insect repellent is a substance directly applied to skin or clothing in order to repel flies, mosquitoes, ticks etc. IR3535 or Ethyl butylacetylaminopropionate (EBAAP) is a relatively new repellent which is classified as a biopesticide due to exceptional skin tolerance and overall safety. The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged. However, there has been no attempt to investigate the effects on microorganisms or viruses up to now. In the present study, antimicrobial activity was investigated based on disc diffusion and micro-well dilution assays. Disc diffusion assays revealed IR3535 displayed remarkable antimicrobial activity on the microorganisms tested. MIC results showed that the antifungal efficiency of IR3535 is higher with respect to its antibacterial and anticandidal efficiency. Moreover, antiviral test results revealed that IR3535 showed antiviral effects against Poliovirus and Adenovirus. This is the first study that reveals IR3535’s antimicrobial and antiviral properties against a broad range of microorganisms and viruses. In consideration of the antimicrobial and antiviral properties, IR3535 is a promising agent that could be used to develop novel therapeutic approaches, new application areas and formulations in the future.",{"EN":392},"Determination of antimicrobial and antiviral properties of 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M. & Przyjemski, J., 1979. Biochim. Biophys. Acta 564: 246–263.\nHillar, M. & Przyjemski, J., 1980. Mol. Biol. Reports 6: 67–71.\nGianfranceschi, G. L., Hillar, M., Chan, J. T. & Amici, D., 1980. Mol. Biol. Reports 6: 95–103.\nHillar, M., Przyjemski, J. & Stolzmann, Z., 1980. Mol. Biol. Reports 6: 89–94.\nHillar, M., Przyjemski, J. & Wyborny, L. E., 1980. Mol. Biol. Reports 6: 169–177.\nBusch, H., 1967. In: Methods in Enzymology (Colowick, S. P. & Kaplan, N. O., eds.) pp. 421–448, Vol. XII, pt A, Academic Press, New York.\nLitman, R. M., 1968. J. Biol. Chem. 243: 6222–6233.\nAlberts, B. & Herrick, G., 1978. In: Methods in Enzymology (Colowick, S. P. & Kaplan, N. O., eds.), pp. 198–217, Vol. XXI, pt. D, Academic Press, New York.\nHillar, M., Rangayya, V., Jafar, B. B., Chambers, D., Vitzu, M. & Wyborny, L. E., 1979. Arch. Internat. Physiol. Biochim. 87: 29–49.\nLowry, O., Rosebrough, N. J., Farr, A. L. & Randall, R., 1951. J. Biol. Chem. 193: 265–275.\nBøvre, K. & Szybalski, W., 1971. In: Methods in Enzymology (Colowick, S. P. & Kaplan, N. O., eds.), pp. 350–383, Vol. XXI, pt. D, Academic Press, New York.\nHillar, M., Davis, S. A. & Chambers, D., 1977. Physiol. Chem. Phys. 9: 205–215.",{"EN":495},"Isolated, deproteinized nucleic acids from calf thymus and rat liver nuclei were fractionated on Bio-Gel A-5m into DNA and RNA fractions. Extraction of deproteinized DNA and nuclear RNA with 80% ethanol at pH 9.5 yielded low molecular weight peptides (deprimerones) capable of inhibiting DNA transcription in a cell-free system. The extracted peptidic fractions were further fractionated on a Sephadex G-25 column and collected as a fraction of mol. wt. between 1 500 and 600. The yield of DNA deprimerones was about 30 μg\u002Fmg DNA and of nuclear RNA deprimerones (150–200 μg\u002Fmg RNA (measured by amino acid composition). The nucleoplasm contained a negligible amount of free, soluble peptides (about 18 μg\u002Fg tissue). The DNA and RNA deprimerones were characterized by their amino acid composition and by two-dimensional thin layer chromatography on cellulose gel plates which yielded two major and two minor fractions. DNA deprimerones isolated in this way are very similar, if not identical, to the affinity DNA deprimerones isolated from a nuclear extract on DNA-cellulose but differ from RNA deprimerones. DNA and RNA deprimerones were also compared with the nuclear deprimerones extracted directly from the lysed nuclei. Their amino acid composition is different from both DNA and nuclear RNA deprimerones. Two-dimensional thin layer chromatography on cellulose plates yielded about ten fractions (spots) with various amino acid composition and inhibitory activity for cell-free transcription.",{"EN":497},"Nuclear deprimerones (Low molecular weight peptides controlling gene expression) are associated with DNA and nuclear RNA",{"VOID":499},"10.1007\u002FBF00777243","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00777243",[502,517,533,545,560,572],{"id":503,"sortIndex":181,"researcher":18,"roles":504,"affiliations":505,"properties":514},"6140f5af-68aa-463a-ad68-ed0651201b44",[280],[506],{"id":18,"sortIndex":19,"affiliation":507,"properties":18},{"id":508,"createTime":509,"updateTime":509,"relativeEntities":510,"slug":18,"properties":511,"entityType":54,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8fe4f3bd-6f41-4fb4-9038-faa469365cd2","2023-12-20T04:07:28.319+00:00",[],{"title":512},{"VI":513},"Veterans Administration Medical Center, Houston, USA",{"title":515},{"VI":516},"L. 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SN, Carr DB, Cohen M et al (2020) The revised IASP definition of pain: Concepts, challenges, and compromises. Pain 161:1976\nWang Y, Beekman J, Hew J et al (2018) Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring. Adv Drug Deliv Rev 123:3–17. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.addr.2017.09.018\nNewberry JA, Bills CB, Pirrotta EA et al (2019) Timely access to care for patients with critical burns in India: a prehospital prospective observational study. Emerg Med J 36:176–182\nNelson S, Conroy C, Logan D (2019) The biopsychosocial model of pain in the context of pediatric burn injuries. Eur J pain 23:421–434\nKlifto KM, Dellon AL, Hultman CS (2021) Prevalence and associated predictors for patients developing chronic neuropathic pain following burns. Burn Trauma 8. https:\u002F\u002Fdoi.org\u002F10.1093\u002FBURNST\u002FTKAA011\nFernandes V, Sharma D, Vaidya S et al (2018) Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges. Expert Opin Ther Targets 22:131–142. https:\u002F\u002Fdoi.org\u002F10.1080\u002F14728222.2018.1420781\nWood JN (2020) The oxford handbook of the neurobiology of pain. Oxford University Press\nAkhilesh UA, Gadepalli A et al (2022) Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain. Life Sci 288:120187. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.lfs.2021.120187\nGreen DP, Ruparel S, Gao X et al (2016) Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury. 12:1–9. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1744806916661725\nVandewauw I, Clercq K, De, Mulier M et al (2018) Letter A TRP channel trio mediates acute noxious. Nat Publ Gr. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnature26137\nAl-Shamlan F, El-Hashim AZ (2019) Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase. Respir Res 20. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12931-019-1060-8\nKádková A, Synytsya V, Krusek J et al (2017) Molecular basis of TRPA1 regulation in nociceptive neurons. A review.Physiol Res66\nChoi S-I, Hwang SW (2018) Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception. Biomol Ther (Seoul) 26:255\nPatil MJ, Salas M, Bialuhin S et al (2020) Sensitization of small-diameter sensory neurons is controlled by TRPV1 and TRPA1 association. FASEB J 34:287–302\nCai W, Cao J, Ren X et al (2015) shRNA mediated knockdown of Nav1. 7 in rat dorsal root ganglion attenuates pain following burn injury. BMC Anesthesiol 16:59\nShields SD, Cheng X, Üçeyler N et al (2012) Sodium channel Nav1. 7 is essential for lowering heat pain threshold after burn injury. J Neurosci 32:10819–10832\nMeglič A, Perkovič-Benedik M, Podkrajšek KT, Bertok S (2014) Painful micturition in a small child: an unusual clinical picture of paroxysmal extreme pain disorder. Pediatr Nephrol 29:1643–1646\nde Greef BTA, Hoeijmakers JGJ, Geerts M et al (2019) Lacosamide in patients with Nav1. 7 mutations-related small fibre neuropathy: a randomized controlled trial. Brain 142:263–275\nCregg JM, DePaul MA, Filous AR et al (2014) Functional regeneration beyond the glial scar. Exp Neurol 253:197–207\nCox JJ, Reimann F, Nicholas AK et al (2006) An SCN9A channelopathy causes congenital inability to experience pain. Nature 444:894–898. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnature05413\nHagen NA, du Souich P, Lapointe B et al (2008) Tetrodotoxin for moderate to severe cancer pain: a randomized, double blind, parallel design multicenter study. J Pain Symptom Manage 35:420–429\nSalas MM, Mcintyre MK, Petz LN et al (2015) Neuroscience Letters Tetrodotoxin suppresses thermal hyperalgesia and mechanical allodynia in a rat full thickness thermal injury pain model. Neurosci Lett 607:108–113. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.neulet.2015.09.031\nMao X-F, Ahsan MZ, Apryani E et al (2020) Dual µ-opioid receptor and norepinephrine reuptake mechanisms contribute to dezocine-and tapentadol-induced mechanical antiallodynia in cancer pain. Eur J Pharmacol 876:173062\nŠutulović N, Grubač Ž, Šuvakov S et al (2019) Chronic prostatitis\u002Fchronic pelvic pain syndrome increases susceptibility to seizures in rats and alters brain levels of IL-1β and IL-6. Epilepsy Res 153:19–27\nAlvarez P, Bogen O, Levine JD (2019) Interleukin 6 decreases nociceptor expression of the potassium channel KV1. 4 in a rat model of hand-arm vibration syndrome. Pain 160:1876\nVit J-P, Clauw DJ, Moallem T et al (2006) Analgesia and hyperalgesia from CRF receptor modulation in the central nervous system of Fischer and Lewis rats. Pain 121:241–260\nSosanya NM, Trevino AV, Chavez RL et al (2017) Sound-stress-induced altered nociceptive behaviors are associated with increased spinal CRFR2 gene expression in a rat model of burn injury. J Pain Res 10:2135\nHuang P-C, Tsai K-L, Chen Y-W et al (2017) Exercise combined with ultrasound attenuates neuropathic pain in rats associated with downregulation of IL-6 and TNF-α, but with upregulation of IL-10. Anesth Analg 124:2038–2044\nStanojcic M, Chen P, Harrison RA et al (2014) Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury. Crit Care Med 42:1357\nSkoff AM, Zhao C, Adler JE (2009) Interleukin-1α regulates substance P expression and release in adult sensory neurons. Exp Neurol 217:395–400\nBernardino L, Xapelli S, Silva AP et al (2005) Modulator effects of interleukin-1β and tumor necrosis factor-α on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci 25:6734–6744\nDu G-H, Wang J-K, Richards JR, Wang J-J (2019) Genetic polymorphisms in tumor necrosis factor alpha and interleukin-10 are associated with an increased risk of cervical cancer. Int Immunopharmacol 66:154–161\nWolf SE (2016) TnF- α \u002F il-10 ratio correlates with Burn severity and May serve as a risk Predictor of increased susceptibility to infections. 4:1–11. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffpubh.2016.00216\nSchaible H-G (2014) Nociceptive neurons detect cytokines in arthritis. Arthritis Res Ther 16:1–9\nZhang A, Lee YC (2018) Mechanisms for joint pain in rheumatoid arthritis (RA): from cytokines to central sensitization. Curr Osteoporos Rep 16:603–610\nSchroder K, Tschopp J (2010) Review The Inflammasomes. 821–832. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cell.2010.01.040\nDinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27:519–550\nRen K, Torres R (2009) Role of interleukin-1β during pain and inflammation. Brain Res Rev 60:57–64\nMilligan ED, Watkins LR (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10:23–36. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnrn2533\nLi T, Chen X, Zhang C et al (2019) An update on reactive astrocytes in chronic pain. J Neuroinflammation 16:1–13. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12974-019-1524-2\nBiber K, Neumann H, Inoue K, Boddeke HWGM (2007) Neuronal ‘On’and ‘Off’signals control microglia. Trends Neurosci 30:596–602\nGuan Z, Kuhn JA, Wang X et al (2016) Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci 19:94–101\nSorkin LS, Svensson CI, Jones-Cordero TL et al (2009) Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat. J Neurosci Res 87:948–955. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fjnr.21905\nChang Y-W, Waxman SG (2010) Minocycline attenuates mechanical allodynia and central sensitization following peripheral second-degree burn injury. J Pain 11:1146–1154\nGuasti L, Richardson D, Jhaveri M et al (2009) Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. Mol Pain 5:35\nMa L, Zhou Y, Khan MAS et al (2019) Burn-induced microglia activation is associated with motor neuron degeneration and muscle wasting in mice. Shock 51:569\nFernandez-Lizarbe S, Montesinos J, Guerri C (2013) Ethanol induces TLR 4\u002FTLR 2 association, triggering an inflammatory response in microglial cells. J Neurochem 126:261–273\nNicotra L, Loram LC, Watkins LR, Hutchinson MR (2012) Toll-like receptors in chronic pain. Exp Neurol 234:316–329. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.expneurol.2011.09.038\nZhang T, Zhang R, Xu B et al (2021) Spinal endomorphins attenuate burn-injury pain in male mice by inhibiting p38 MAPK signaling pathway through the mu-opioid receptor. Eur J Pharmacol 903:174139\nQiu J-L, Zhu W-L, Lu Y-J et al (2015) The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6\u002FNF-κB pathway in BV2 microglial cells. Neurochem Int 85:46–52\nMai L, Zhu X, Huang F et al (2020) P38 Mitogen-Activated Protein Kinase and Pain. Life Sci 256:117885. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.lfs.2020.117885\nIpaktchi K, Mattar A, Niederbichler AD et al (2006) Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury. J Immunol 177:8065–8071\nCarter D, Warsen A, Mandell K et al (2014) Delayed topical p38 MAPK inhibition attenuates full-thickness burn wound inflammatory signaling. J Burn Care Res 35:e83–e92\nHoesel LM, Mattar AF, Arbabi S et al (2009) Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction. Surgery 146:775–786\nWang S, Lee J-S, Hyun J et al (2015) Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury. Stem Cell Res Ther 6:20\nLiu L, Song H, Duan H et al (2016) TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn- induced excessive inflammation via inhibiting activations of P38 and JNK signaling. 1–13. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsrep30121\nPadhy B, Kapuganti RS, Hayat B et al (2019) De novo variants in an extracellular matrix protein coding gene, fibulin-5 (FBLN5) are associated with pseudoexfoliation. Eur J Hum Genet 27:1858–1866\nYanagisawa H, Schluterman MK, Brekken RA (2009) Fibulin-5, an integrin-binding matricellular protein: Its function in development and disease. J Cell Commun Signal 3:337–347. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs12079-009-0065-3\nZheng Q, Choi J, Rouleau L et al (2006) Normal wound healing in mice deficient for fibulin-5, an elastin binding protein essential for dermal elastic fiber assembly. J Invest Dermatol 126:2707–2714. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsj.jid.5700501\nLee MJ, Roy NK, Mogford JE et al (2004) Fibulin-5 promotes wound healing in vivo. J Am Coll Surg 199:403–410\nHou X, Li H, Zhang C et al (2017) Overexpression of Fibulin-5 attenuates burn-induced inflammation via TRPV1\u002FCGRP pathway. Exp Cell Res 357:320–327. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.yexcr.2017.05.029\nWozniak KM, Rojas C, Wu Y, Slusher BS (2012) The Role of Glutamate Signaling in Pain Processes and its Regulation by GCP II Inhibition. 1323–1334\nTiwari V, Tiwari V, He S et al (2016) Mas-related G protein-coupled receptors offer potential new targets for pain therapy. Transl Res pain itch 87–103\nChouhan D, Uniyal A, Gadepalli A et al (2020) Probing the Manipulated Neurochemical Drive in Alcohol Addiction and Novel Therapeutic Advancements. ACS Chem Neurosci 11:1210–1217. https:\u002F\u002Fdoi.org\u002F10.1021\u002Facschemneuro.0c00073\nUniyal A, Thakur V, Rani M et al (2021) Kinesin Nanomotors Mediated Trafficking of NMDA-Loaded Cargo as A Novel Target in Chronic Pain. ACS Chem Neurosci 12:2956–2963. https:\u002F\u002Fdoi.org\u002F10.1021\u002Facschemneuro.1c00319\nMorgan M, Deuis JR, Frøsig-Jørgensen M et al (2018) Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Med 19:708–734\nStoicea N, Russell D, Weidner G et al (2015) Opioid-induced hyperalgesia in chronic pain patients and the mitigating effects of gabapentin. Front Pharmacol 6:104\nVan Elstraete AC, Tirault M, Lebrun T et al (2008) The median effective dose of preemptive gabapentin on postoperative morphine consumption after posterior lumbar spinal fusion. Anesth Analg 106:305–308\nCuignet O, Pirson J, Soudon O, Zizi M (2007) Effects of gabapentin on morphine consumption and pain in severely burned patients. Burns 33:81–86. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.burns.2006.04.020\nLi Z, Zhang B, Li W, Wang Q (2015) Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn. Chin J Burn 31:177–180. https:\u002F\u002Fdoi.org\u002F10.3760\u002Fcma.j.issn.1009-2587.2015.03.005\nJun JH, Yaksh TL (1998) The effect of intrathecal gabapentin and 3-isobutyl γ-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesth Analg 86:348–354. https:\u002F\u002Fdoi.org\u002F10.1097\u002F00000539-199802000-00025\nGray P, Williams B, Cramond T (2008) Successful use of gabapentin in acute pain management following burn injury: A case series. Pain Med 9:371–376. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1526-4637.2006.00149.x\nChinchilla PA, Moyano J (2021) Efficacy of opioids and non-opioid analgesics in the treatment of post procedure pain of burned patients: a narrative review. Brazilian J Anesthesiol (English Ed. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bjane.2021.07.022\nJones TL, Sorkin LS (2005) Activated PKA and PKC, but not CaMKIIα, are required for AMPA\u002Fkainate-mediated pain behavior in the thermal stimulus model. Pain 117:259–270\nWang H, Woolf CJ (2005) Pain TRPs. Neuron 46:9–12\nJones TL, Sorkin LS (2004) isoxazolepropionic Acid \u002F Kainate Receptors Mediate Development, but Not Maintenance, of Secondary Allodynia Evoked by First-Degree Burn in the Rat. Pharmacology 310:223–229. https:\u002F\u002Fdoi.org\u002F10.1124\u002Fjpet.103.064741.sensitization\nDistrict SQ, Hassanpour-Ezatti M, Haghparast A (2012) Glutamate receptors in nucleus accumbens can modulate canabinoid-induced antinociception in rats basolateral amygdala.Basic Clin Neurosci3\nBleakman D, Alt A, Nisenbaum ES (2006) Glutamate receptors and pain. Seminars in cell & developmental biology. Elsevier, pp 592–604\nWarncke T, Stubhaug A, Jørum E (1997) Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo. Pain 72:99–106. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0304-3959(97)00006-7\nZieglgänsberger W (2019) Substance P and pain chronicity. Cell Tissue Res 375:227–241\nLembeck F, Gamse R (1982) Substance P in peripheral sensory processes. Subst P Nerv Syst 91:35–54\nMantyh PW, Rogers SD, Honore P et al (1997) Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Sci (80-) 278:275–279\nSeybold VS (2009) The role of peptides in central sensitization.Sens Nerves451–491\nBardoni R, Torsney C, Tong C-K et al (2004) Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci 24:2774–2781\nMarchand F, Perretti M, McMahon SB (2005) Role of the immune system in chronic pain. Nat Rev Neurosci 6:521–532\nShinohara K, Watabe AM, Nagase M et al (2017) Essential role of endogenous calcitonin gene-related peptide in pain‐associated plasticity in the central amygdala. Eur J Neurosci 46:2149–2160\nNatura G, von Banchet GS, Schaible H-G (2005) Calcitonin gene-related peptide enhances TTX-resistant sodium currents in cultured dorsal root ganglion neurons from adult rats. Pain 116:194–204\nOnuoha GN, Alpar EK (2001) Levels of vasodilators (SP, CGRP) and vasoconstrictor (NPY) peptides in early human burns. 253–257\nWang D, Tawfik VL, Corder G et al (2018) Functional divergence of delta and mu opioid receptor organization in CNS pain circuits. Neuron 98:90–108\nScherrer G, Imamachi N, Cao Y-Q et al (2009) Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 137:1148–1159\nSánchez-Brualla I, Boulenguez P, Brocard C et al (2018) Activation of 5-HT 2A Receptors Restores KCC2 Function and Reduces Neuropathic Pain after Spinal Cord Injury. Neuroscience 387:48–57. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.neuroscience.2017.08.033\nGuan Y, Johanek LM, Hartke TV et al (2008) Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain 138:318–329\nEmery MA, Bates MLS, Wellman PJ, Eitan S (2017) Burn injury decreases the antinociceptive effects of opioids. Behav Pharmacol 28:285–293\nUniyal A, Gadepalli A, Akhilesh, Tiwari V (2020) Underpinning the Neurobiological Intricacies Associated with Opioid Tolerance. ACS Chem Neurosci 11:830–839. https:\u002F\u002Fdoi.org\u002F10.1021\u002Facschemneuro.0c00019\nTiwari V, He SQ, Huang Q et al (2020) Activation of µ-d Opioid receptor heteromers inhibits neuropathic pain behavior in rodents. Pain 161:842–855. https:\u002F\u002Fdoi.org\u002F10.1097\u002Fj.pain.0000000000001768\nTiwari V, Anderson M, Yang F et al (2018) Peripherally Acting µ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats. Anesthesiology 128:1220–1236. https:\u002F\u002Fdoi.org\u002F10.1097\u002FALN.0000000000002191\nVaidya S, Shantanu PA, Tiwari V (2021) Attenuation of ongoing neuropathic pain by peripheral acting opioid involves activation of central dopaminergic neurocircuitry. Neurosci Lett 754:135751. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.neulet.2021.135751\nTiwari V, Yang F, He S-Q et al (2016) Activation of peripheral µ-opioid receptors by dermorphin [D-Arg2, Lys4](1–4) amide leads to modality-preferred inhibition of neuropathic pain. Anesthesiology 124:706–720\nDanilov A, Kurganova J (2016) Melatonin in chronic pain syndromes. Pain Ther 5:1–17\nMaldonado M-D, Murillo-Cabezas F, Calvo J-R et al (2007) Melatonin as pharmacologic support in burn patients: A proposed solution to thermal injury–related lymphocytopenia and oxidative damage. Crit Care Med 35:1177–1185\nNg KY, Leong MK, Liang H, Paxinos G (2017) Melatonin receptors: distribution in mammalian brain and their respective putative functions. Brain Struct Funct 222:2921–2939\nde Zanette SA, Vercelino R, Laste G et al (2014) Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. BMC Pharmacol Toxicol 15:40\nUlmann L, Hatcher JP, Hughes JP et al (2008) Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci 28:11263–11268\nMeng X, Gao J, Zuo J-L et al (2017) Toll-like receptor-4\u002Fp38 MAPK signaling in the dorsal horn contributes to P2X4 receptor activation and BDNF over-secretion in cancer induced bone pain. Neurosci Res 125:37–45\nLee-Hotta S, Uchiyama Y, Kametaka S (2019) Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: a mini review. Neurochem Int 128:32–38\nYang H, Feng G-D, Liang Z et al (2012) In vitro beneficial activation of microglial cells by mechanically-injured astrocytes enhances the synthesis and secretion of BDNF through p38MAPK. Neurochem Int 61:175–186\nSolway B, Bose SC, Corder G et al (2011) Tonic inhibition of chronic pain by neuropeptide Y. Proc Natl Acad Sci 108:7224–7229\nYin K, Deuis JR, Lewis RJ, Vetter I (2016) Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Mol Pain 12:1–13. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1744806916665366\nZeng Q, Man R, Luo Y et al (2017) IRF-8 is involved in Amyloid-β1–40 (Aβ1–40)-induced microglial activation: a new implication in Alzheimer’s disease. J Mol Neurosci 63:159–164\nRao PN, Mainkar O, Bansal N et al (2021) Flavonoids in the Treatment of Neuropathic Pain. Curr Pain Headache Rep 25. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11916-021-00959-y\nShao B, Wei W, Ke P et al (2014) Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and inhibiting NLRP 3 inflammasome. CNS Neurosci Ther 20:1021–1028\nGe M-M, Zhou Y-Q, Tian X-B et al (2020) Src-family protein tyrosine kinases: A promising target for treating chronic pain. Biomed Pharmacother 125:110017\nNie L, Ye W-R, Chen S et al (2021) Src family kinases in the central nervous system: their emerging role in pathophysiology of migraine and neuropathic pain. Curr Neuropharmacol 19:665–678\nClark AK, Yip PK, Grist J et al (2007) Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci 104:10655–10660\nYe L, Xiao L, Yang SY et al (2017) Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats. Neuroscience 344:265–275",{"EN":717},"Burn injuries are among the highly prevalent medical conditions worldwide that occur mainly in children, military veterans and victims of fire accidents. It is one of the leading causes of temporary as well as permanent disabilities in patients. Burn injuries are accompanied by pain that persists even after recovery from tissue damage which puts immense pressure on the healthcare system. The pathophysiology of burn pain is poorly understood due to its complex nature and lack of considerable preclinical and clinical shreds of evidence, that creates a substantial barrier to the development of new analgesics. Burns damage the skin layers supplied with nociceptors such as NAV1.7, TRPV1, and TRPA1. Burn injury-mediated co-localization and simultaneous activation of TRPA1 and TRPV1 in nociceptive primary afferent C-fibers which contributes to the development and maintenance of chronic pain. Burn injuries are accompanied by central sensitization, a key feature of pain pathophysiology mainly driven by a series of cascades involving aberrations in the glutamatergic system, microglial activation, release of neuropeptides, cytokines, and chemokines. Activation of p38 mitogen-activated protein kinase, altered endogenous opioid signaling, and distorted genomic expression are other pathophysiological factors responsible for the development and maintenance of burn pain. Here we discuss comprehensive literature on molecular mechanisms of burn pain and potential targets that could be translated into near future therapeutics.",{"EN":719},"Multifactorial pathways in burn injury-induced chronic pain: novel targets and their pharmacological modulation",{"VOID":721},"10.1007\u002Fs11033-022-07748-9","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11033-022-07748-9",[724,739,751,763],{"id":725,"sortIndex":141,"researcher":18,"roles":726,"affiliations":727,"properties":736},"50468a62-5df9-4c6b-8b1a-4df7e7e7d864",[280],[728],{"id":18,"sortIndex":19,"affiliation":729,"properties":18},{"id":730,"createTime":731,"updateTime":731,"relativeEntities":732,"slug":18,"properties":733,"entityType":54,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"1d75f979-057c-4fc1-ab64-962f61989312","2024-02-10T22:22:46.981+00:00",[],{"title":734},{"VI":735},"Neuroscience & Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, India",{"title":737},{"VI":738},"Akhilesh",{"id":740,"sortIndex":278,"researcher":18,"roles":741,"affiliations":742,"properties":748},"5664596a-a0b3-4700-a0ad-43b186064682",[280],[743],{"id":18,"sortIndex":19,"affiliation":744,"properties":18},{"id":730,"createTime":731,"updateTime":731,"relativeEntities":745,"slug":18,"properties":746,"entityType":54,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":747},{"VI":735},{"title":749},{"VI":750},"Ankit 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G.M.Kung & J.Bonner. J. Mol. Biol. 39: 351–364 (1969).\nBlüthmannH. Eur. J. Biochem. 70: 233–240 (1976).\nBlüthmannH., S.Mrozek & A.Gierer. Eur. J. Biochem. 58: 315–326 (1975).\nBlüthmann, H. Int. J. Biochem. (in press).\nDavidsonE.H. & R.J.Britten. Q. Rev. Biol. 48: 565–613 (1973).\nGiererA. Cold Spring Harbor Symp. Quant. Biol. 38: 951–961 (1973).\nHausenP., H.Stein & H.Peters. Eur. J. Biochem. 9: 542–549 (1969).\nHemminkiK. Exptl. Cell Res. 93: 63–70 (1975).\nHuangR.C. & P.C.Huang (1969). J. Mol. Biol. 39: 365–378 (1969).\nJohnsonE.M., J.Karn & V.G.Allfrey. J. Biol. Chem. 249: 4990–4999 (1974).\nKleinsmithL.J., V.G.Allfrey & A.E.Mirsky. Science 154: 780–781 (1966).\nLaemmliU.K. Nature 227: 680–685 (1970).\nLevyR., S.Levy, S.A.Rosenberg & R.T.Simpson. Biochemistry 12: 224–228 (1973).\nLevyR. & S.A.Rosenberg. J. Immunol. 108: 1073–1079 (1972).\nPogoB.G.T., V.G.Allfrey & A.E.Mirski. Proc. Natl. Acad. Sci. USA 55: 805–812 (1966).\nRenaudJ., M.C.Eggo & W.I.Waithe. Ann. Immunol. (Inst. Pasteur) 128C: 909–913 (1977).\nRosenbergS. & R.Levyt J. Immunol. 108: 1105–1109 (1972).\nShapiroA.L., E.Vinuela & J.V.Maizel. Biochem. Biophys. Res. Comm. 28: 815–820 (1967).",{"EN":820},"Stimulation of bovine lymphocytes with phytohemagglutinin results in quantitative as well as qualitative changes in the nonhistone chromosomal proteins. Analysis of these proteins by hydroxyapatite chromatography and sodium dodecylsulfate polyacrylamide gel electrophoresis shows not only a selective increase in the amount of some nonhistone proteins but also a decrease of other nonhistone protein bands. This observation is compatible with the view that nonhistone proteins have an inhibitory as well as an activating function at the genome level.",{"EN":822},"Changes in nonhistone chromosomal proteins in phytohemagglutininstimulated lymphocytes",{"VOID":824},"10.1007\u002FBF00775968","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF00775968",[827],{"id":828,"sortIndex":19,"researcher":18,"roles":829,"affiliations":830,"properties":839},"b9675726-4676-4ad1-a88a-a39c1cd552e4",[280],[831],{"id":18,"sortIndex":19,"affiliation":832,"properties":18},{"id":833,"createTime":834,"updateTime":834,"relativeEntities":835,"slug":18,"properties":836,"entityType":54,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"57a70035-d370-4a1b-8245-77b70010653a","2024-01-09T00:30:23.674+00:00",[],{"title":837},{"VI":838},"Max-Planck-Institut für Virusforschung, Tübingen, German Fed. 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Annu Rev Anthropol 32:135–162\nCavalli-Sforza LL, Menozzi P, Piazza A (1997) The history and geography of human genes. Princeton University Press, Princeton, NJ\nThomson G et al (2001) Chapter 23: Human diversity and variation: mathematical tools and models for defining relationships between different populations. International Histocompatibility Working Group, pp TM23-1-TM23-11\nFranco RF, Maffel F, Lourenco D, Piccinato C, Morelli V, Thomazini I, Zago Marco (1998) The frequency of 844 ins. 68b.p mutation in the CBS gene is not increased in patient with venous thrombosis. Hematological 83:1006–1008\nSebastio G, Sperandeo MP, Panico M, De Franchis R, Kraus VIP, Andria G (1995) The molecular basic of homocysteinuria due to Cystathionine β-synthase deficiency in Italian families, and report of four novel mutations. Am J Hum Genet 56:1324–1333\nMudd SH, Levy HL, Skovby B (1995) Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited diseases, 7th edn. McGraw-Hill, New York, pp 1279–1327\nKluijtmans LAJ, Boers GHJ, Trijbels FJM, van Lith-Zanders HMA, van den Heuvel LPWJ, Blom HJ (1997) A common 844INS68 insertion variant in the Cystathionine beta synthase gene. Biochem Mol Med 62:23–25\nZoossmann-Diskin A, Gazit E, Peleg L, Shohat M, Turner D (2004) 844 INS.68bp in the Cystathionine β-synthase gene in Israel and review of its distribution in the world. Anthropol Anz 62(2):147–155\nSambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. Cold Spring Harbor Laboratory Press, New York\nGiusti B, Camacho-Vanegas O, Attanasio M et al (1999) Microheterogeneity in the distribution of the 844ins68 in the cystathionine ß-synthase gene in Italy. Thromb Res 94:249–254\nPepe G, Camacho Vanegas O ,Richards O, Giusti B, Comeglio P, Prisco D, Gensini GF, Albate R (1999) World distribution of the T833C\u002F844 ins. 68bp CBS in Cis double mutation: a reliable anthropological marker. Hum Genet 104:126–129\nCaudill MA, Wang JC, Melnyk S, Pogribny IP, Jernigan S, Collins MD, Santos-Guzman J, Swendseid ME, Cogger EA, James SJ (2001) Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr 131:2811–2818\nUnderhill PA, Jin L, Oefner PJ, Cavalli-Sforza LL (1995) Y-chromosomal variation and recent conquests in deciphering human origins. Am J Hum Genet 57(Suppl.):A4313\nSu B, Xiao J, Underhill P, Deka R, Zhang W, Akey J, Huang W, Shen D, Lu D, Luo J, Chu J, Tan J, Shen P, Davis R, Cavalli-Sforza L, Chakraborty R, Xiong M, Du R, Oefner P, Chen Z, Jin L (1999) Y-chromosome evidence for a northward migration of modern humans into eastern Asia during the last ice age. Am J Hum Genet 65:1718–1724\nLubon G The civilization of Islam and Arabs, Persian translation by Hussein SH, 1st edn., pp 218–219, 368–375\nDe Stefano V, Dekou V, Nicaud V, Chasse JF, London J, Stansbie D, Humphries SE, Gudnason V (1998) Linkage disequilibrium at the CBS locus and association between genetic variation at the CBS locus and plasma level of homocysteine. Ann Hum Genet 62:481–490\nFranco RF, Elion J, Lavinha J, Krishnamoorthy R, Tavella MH, Zago MA (1998) Heterogeneous ethnic distribution of the 844 INS 68bp in the cystathionine β-synthase gene. Hum Hered 48:338–342\nAmirzagar A, Mytilineos J, Farjadian S, Daroudchi M, Scherer S, Opelz G, Ghaderi A (2001) Human leukocyte antigen class II allele frequencies and haplotype association in Iranian normal population. Hum Immunol 62:1234–1238\nBazrgar M, Karimi M, Fathzadeh M, Senemar S, Peiravian F, Shojaee A, Saadat M (2007) Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts. Mol Biol Rep June 27 (Epub ahead of print)\nIranians before Iran, chapter 2. History of Iran. www.iranologie.com\u002F history 2 html\nRickards O, Biondi G, De Stefano GF, Vecchi F, Walter H (1992) Genetic structure of the population of Sicily. Am J Phys Anthropol 87(4):395–406\nWalter M, Mastsumoto H, Danker-Hopfe H, De Stefano GF, Rickards O (1997) GM and KM allotypes in nine population samples of Sicily. Ann Hum Biol 24(5):419–426\nDilley A, Hooper WC, El-Jamil M, Renshaw M, Wenger NK, Evatt BL (2001) Mutations in the genes regulating methylenetetrahydrofolate reductase (MTHFR C→T677) and cystathione β-synthase (CBS G→A919, CBS T→C833) are not associated with myocardial infarction in African Americans. Thromb Res 103:109–115",{"EN":887},"Iranian population with an Indo-European origin is one of the oldest populations in the world. Historical evidence suggests the close similarity in the origin of Iranian, European and north Indian population. However, there are few anthropological and genetic evidences on this subject. This study, which is the first report from Iran, was performed to investigate the genetic origin of Iranian population using a polymorphism in Cystathionine beta synthase (CBS) gene known as 844INS68bp in this respect, genomic DNA was extracted from the whole blood of 480 healthy normal blood donors referred to Fars Blood Transfusion Center, using a salting out method. The fragment containing 844INS68bp was amplified, the normal fragment was 174 bp and the fragment containing the insertion was 242 bp in length. Results indicated that 418 (87.08%) out of 480 individuals had a normal (N\u002FN) genotype, 59 (12.29%) individuals were heterozygote (N\u002FI) and 3 (0.63%) had homozygote a mutated genotype (I\u002FI). The total frequency of 844INS68bp allele was found 6.8% which is similar to with the reported in White Caucasians. Comparison of the genotype of this study with the polymorphism in other populations revealed that Southern Iranian population has a great similarity with other Caucasians populations’ especially South Italy and North America while differed from East Asian and African populations. These results are in agreement with the result of other studied polymorphisms. 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KM, O’Connell P, Martin GA et al (1994) Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med 330:597–601",{"doi":1228},"10.1056\u002FNEJM199403033300903",{"id":18,"text":1230,"url":18,"identifiers":1231},"Sorensen SA, Mulvihill JJ, Nielsen A (1986) Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms. New Engl J Med 314:1010–1015",{"doi":1232},"10.1056\u002FNEJM198604173141603",{"id":18,"text":1234,"url":18,"identifiers":1235},"Jin P, Yan K, Ye S et al (2021) Case Report: a synonymous mutation in NF1 located at the non-canonical splicing site leading to exon 45 skipping. Front Genet 12:772958",{"doi":1236},"10.3389\u002Ffgene.2021.772958",{"id":18,"text":1238,"url":18,"identifiers":1239},"Bernier A, Larbrisseau A, Perreault S (2016) Cafe-au-lait macules and neurofibromatosis type 1: a review of the literature. Pediatr Neurol 60(24–9):e1",{},{"id":18,"text":1241,"url":18,"identifiers":1242},"Alshahrani A, Abuoliat Z, Alshahrani AS et al (2022) Prevalence of associated endocrine diseases in patients with neurofibromatosis type 1. Avicenna J Med 12:16–20",{"doi":1243},"10.1055\u002Fs-0041-1742197",{"id":18,"text":1245,"url":18,"identifiers":1246},"Williams VC, Lucas J, Babcock MA et al (2009) Neurofibromatosis type 1 revisited. Pediatrics 123:124–133",{"doi":1247},"10.1542\u002Fpeds.2007-3204",{"id":18,"text":1249,"url":18,"identifiers":1250},"Balcer LJ, Liu GT, Heller G et al (2001) Visual loss in children with neurofibromatosis type 1 and optic pathway gliomas: relation to tumor location by magnetic resonance imaging. Am J Ophthalmol 131:442–445",{"doi":1251},"10.1016\u002FS0002-9394(00)00852-7",{"id":18,"text":1253,"url":18,"identifiers":1254},"Ledbetter DH, Rich DC, O’Connell P et al (1989) Precise localization of NF1 to 17q11.2 by balanced translocation. Am J hum genet 44:20–24",{},{"id":18,"text":1256,"url":18,"identifiers":1257},"Wallace MR, Andersen LB, Saulino AM et al (1991) A de novo Alu insertion results in neurofibromatosis type 1. Nature 353:864–866",{"doi":1258},"10.1038\u002F353864a0",{"id":18,"text":1260,"url":18,"identifiers":1261},"Upadhyaya M, Osborn MJ, Maynard J et al (1997) Mutational and functional analysis of the neurofibromatosis type 1 (NF1) gene. Hum Genet 99:88–92",{"doi":1262},"10.1007\u002Fs004390050317",{"id":18,"text":1264,"url":18,"identifiers":1265},"De Luca A, Bottillo I, Sarkozy A et al (2005) NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome. Am J Hum Genet 77:1092–1101",{"doi":1266},"10.1086\u002F498454",{"id":18,"text":1268,"url":18,"identifiers":1269},"Baralle D, Mattocks C, Kalidas K et al (2003) Different mutations in the NF1 gene are associated with Neurofibromatosis-Noonan syndrome (NFNS). Am J Med Genet A 119A:1–8",{"doi":1270},"10.1002\u002Fajmg.a.20023",{"id":18,"text":1272,"url":18,"identifiers":1273},"Trovo-Marqui AB, Tajara EH (2006) Neurofibromin: a general outlook. Clin Genet 70:1–13",{"doi":1274},"10.1111\u002Fj.1399-0004.2006.00639.x",{"id":18,"text":1276,"url":18,"identifiers":1277},"Stewart DR, Brems H, Gomes AG et al (2014) Jaffe-Campanacci syndrome, revisited: detailed clinical and molecular analyses determine whether patients have neurofibromatosis type 1, coincidental manifestations, or a distinct disorder. Genet Med 16:448–459",{"doi":1278},"10.1038\u002Fgim.2013.163",{"id":18,"text":1280,"url":18,"identifiers":1281},"Side LE, Emanuel PD, Taylor B et al (1998) Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. Blood 92:267–272",{"doi":1282},"10.1182\u002Fblood.V92.1.267.413a31_267_272",{"id":18,"text":1284,"url":18,"identifiers":1285},"Ishida C, Gupta V. Genetics, Molecular Testing. StatPearls. Treasure Island (FL), 2021.",{},{"id":18,"text":1287,"url":18,"identifiers":1288},"Sharifi S, Kalayci T, Palanduz S et al (2021) Clinical characteristics and mutation spectrum of neurofibromatosis type 1 in 27 Turkish families. Balkan Med J 38:365–373",{"doi":1289},"10.5152\u002Fbalkanmedj.2021.21006",{"id":18,"text":1291,"url":18,"identifiers":1292},"Kehrer-Sawatzki H, Cooper DN (2022) Challenges in the diagnosis of neurofibromatosis type 1 (NF1) in young children facilitated by means of revised diagnostic criteria including genetic testing for pathogenic NF1 gene variants. Hum Genet 141:177–191",{"doi":1293},"10.1007\u002Fs00439-021-02410-z",{"id":18,"text":1295,"url":18,"identifiers":1296},"Fu J, Li L, Lu G (2002) Relationship between microdeletion on Y chromosome and patients with idiopathic azoospermia and severe oligozoospermia in the Chinese. Chin Med J 115:72–75",{},{"id":18,"text":1298,"url":18,"identifiers":1299},"Cheng J, Fu J, Zhou Q et al (2019) A novel splicing mutation in the PRPH2 gene causes autosomal dominant retinitis pigmentosa in a Chinese pedigree. J Cell Mol Med 23:3776–3780",{"doi":1300},"10.1111\u002Fjcmm.14278",{"id":18,"text":1302,"url":18,"identifiers":1303},"Wang F, Wang H, Tuan HF et al (2014) Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet 133:331–345",{"doi":1304},"10.1007\u002Fs00439-013-1381-5",{"id":18,"text":1306,"url":18,"identifiers":1307},"Zhang Q, Xu M, Verriotto JD et al (2016) Next-generation sequencing-based molecular diagnosis of 35 Hispanic retinitis pigmentosa probands. Sci Rep 6:32792",{"doi":1308},"10.1038\u002Fsrep32792",{"id":18,"text":1310,"url":18,"identifiers":1311},"Imani S, Cheng J, Mobasher-Jannat A et al (2018) Identification of a novel RPGRIP1 mutation in an Iranian family with leber congenital amaurosis by exome sequencing. J Cell Mol Med 22:1733–1742",{"doi":1312},"10.1111\u002Fjcmm.13454",{"id":18,"text":1314,"url":18,"identifiers":1315},"Fu Q, Xu M, Chen X et al (2017) CEP78 is mutated in a distinct type of Usher syndrome. J Med Genet 54:190–195",{"doi":1316},"10.1136\u002Fjmedgenet-2016-104166",{"id":18,"text":1318,"url":18,"identifiers":1319},"Koenekoop RK, Wang H, Majewski J et al (2012) Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet 44:1035–1039",{"doi":1320},"10.1038\u002Fng.2356",{"id":18,"text":1322,"url":18,"identifiers":1323},"Uhlen M, Fagerberg L, Hallstrom BM et al (2015) Proteomics. Tissue-based map of the human proteome. Science 347:1260419",{"doi":1324},"10.1126\u002Fscience.1260419",{"id":18,"text":1326,"url":18,"identifiers":1327},"Fu J, Zhou B, Zhang L et al (2020) Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. Mol Biol Rep 47:4383–4392",{"doi":1328},"10.1007\u002Fs11033-020-05478-4",{"id":18,"text":1330,"url":18,"identifiers":1331},"Cheng J, Peng J, Fu J et al (2020) Identification of a novel germline BRCA2 variant in a Chinese breast cancer family. J Cell Mol Med 24:1676–1683",{"doi":1332},"10.1111\u002Fjcmm.14861",{"id":18,"text":1334,"url":18,"identifiers":1335},"Fu J, Cheng J, Liu X et al (2018) Evaluation genotypes of cancer cell lines HCC1954 and SiHa by short tandem repeat (STR) analysis and DNA sequencing. Mol Biol Rep 45:2689–2695",{"doi":1336},"10.1007\u002Fs11033-018-4438-7",{"id":18,"text":1338,"url":18,"identifiers":1339},"Zhu L, Cheng J, Zhou B et al (2017) Diagnosis for choroideremia in a large Chinese pedigree by nextgeneration sequencing (NGS) and noninvasive prenatal testing (NIPT). Mol Med Rep 15:1157–1164",{"doi":1340},"10.3892\u002Fmmr.2017.6119",{"id":18,"text":1342,"url":18,"identifiers":1343},"Nykamp K, Anderson M, Powers M et al (2017) Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria. Genet Med 19:1105–1117",{"doi":1344},"10.1038\u002Fgim.2017.37",{"id":18,"text":1346,"url":18,"identifiers":1347},"Dugoff L, Sujansky E (1996) Neurofibromatosis type 1 and pregnancy. Am J Med Genet 66:7–10",{"doi":1348},"10.1002\u002F(SICI)1096-8628(19961202)66:1\u003C7::AID-AJMG2>3.0.CO;2-R",{"id":18,"text":1350,"url":18,"identifiers":1351},"Remon-Ruiz P, Aliaga-Verdugo A, Guerrero-Vazquez R (2017) Pheochromocytoma in neurofibromatosis type 1 during pregnancy. Gynecol Endocrinol 33:93–95",{"doi":1352},"10.1080\u002F09513590.2016.1254181",{"id":18,"text":1354,"url":18,"identifiers":1355},"Adams DR, Eng CM (2018) Next-generation sequencing to diagnose suspected genetic disorders. N Engl J Med 379:1353–1362",{"doi":1356},"10.1056\u002FNEJMra1711801",{"id":1358,"createTime":1359,"updateTime":1360,"relativeEntities":1361,"slug":1362,"properties":1363,"entityType":271,"verifyStatus":272,"verifyTime":1372,"verifyNote":273,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1373,"fullTextUrl":18,"authors":1374,"publicationType":343,"publisherRelationship":1515,"citationCount":18,"citationInfo":18,"publishDate":1548,"publishYear":1549,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":379},"dd702518-9590-4a41-8c88-c14e68416400","2024-01-13T11:28:54.997+00:00","2024-12-20T23:58:38.443+00:00",[],"Cloning-and-sequence-analysis-of-the-human-cDNA-encoding-the-synaptoporin-%CE%94-a-highly-conservative-synaptic-vesicle-protein",{"references":1364,"abstract":1366,"title":1368,"doi":1370},{"VOID":1365},"Bixby JL (1992) Identification of an alternatively spliced avian member of the synaptophysin gene family. Brain Res. Mol. Brain Res. 13: 339–348.\nBrandstatter JH, Lohrke S, Morgans CW, Wassle H (1996) Distributions of two homologous synaptic vesicle proteins, synaptoporin and synaptophysin, in the mammalian retina. J. Comp. Neurol. 370: 1–10.\nBuckley KM, Floor E, Kelly RB (1987) Cloning and sequence analysis of cDNA encoding p38, a major synaptic vesicle protein. J. Cell. Biol. 105: 2447–2456.\nCalakos N, Scheller RH (1994) Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle. J. Biol. Chem. 269: 24534–24537.\nCowan D, Linial M, Scheller RH (1990) Torpedo synaptophysin: evolution of a synaptic vesicle protein. Brain Res. 509: 1–7.\nEdelmann L, Hanson PI, Chapman ER, Jahn R (1995) Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. EMBO J. 14: 224–231.\nEshkind LG, Leube RE (1995) Mice lacking synaptophysin reproduce and form typical synaptic vesicles. Cell Tissue Res. 282: 423–433.\nGalli T, Chilcore T, Mondigl O, Binz T, Niemann H, Camilli PD (1994) Tetanus toxin-mediated cleavage of cellubrevin impairs exocytosis of transferring receptor-containing vesicles in CHO cells. J. Cell Biol. 125: 1015–1024.\nGrabs D, Bergmann T, Fox PA, Brich M, Gratz M (1994) Differential expression of synaptophysin and synaptoporin during pre-and postnatal development of the rat hippocampal network. Eur. J. Neurosci. 6: 1765–1771.\nHaass NK, Kartenbeck MA, Leube RE (1996) Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. J. Cell Biol. 134: 731–746.\nKanus P, Marqueze-Pouey B, Scherer H, Betz H (1990) Synaptoporin, a novel putative channel protein of synaptic vesicles. Neuron 5: 453–462.\nRehm H, Wiedenmann B, Betz H (1986) Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane. EMBO J. 5: 535–541.\nRothman JE (1994) Mechanisms of intracellular protein transport. Nature 372: 55–63.\nShimuta M, Komazaki S, Nishi M, Iino M, Nakagawara K, H. Takeshima (1998) Structure and expression of mitsugumin29 gene. FEBS Lett. 431: 263–267.\nStenius K, Janz R, Sudhof TC, Jahn R (1995) Structure of synaptogyrin (p29) defines novel synaptic vesicle protein. J. Cell Biol. 131: 1801–1809.\nSudhof TC, Lottspeich F, Greengard P, Mehl E, Jahn R (1987) A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science 238: 1142–1144.\nTakeshima H, Shimuta M, Komazaki S (1998) Mitsugumin29, a novel synaptophysin family member from the triad junction in skeletal muscle. Biochem. J. 331: 317–322.\nThomas L, Hartung K, Langosch D, Rehm H, Bamberg E, Franke WW, Betz H (1988) Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane. Science 242: 1050–1053.\nWashbourne P, Schiavo G, Montecucco C (1995) Vesicleassociated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin. Biochem. J. 305: 721–724.\nWindoffer R, Borchert-Stuhltrager M, Haass NK, Thomas S, Hergt M, Bulitta CJ, Leube RE (1999) Tissue expression of the vesicle protein pantophysin. Cell Tissue Res. 296: 499–510.",{"EN":1367},"Synaptoporin is a membrane protein of synaptic vesicles, which belongs to the synaptophysin family. It was first isolated from rat brain. Here we report the cloning and characterization of the human cDNA that encodes the human homologue of synaptoporin. It has two splicing variants, which is in accordance with its ortholog in chicken. Its deduced amino acid sequence displays 97% and 81% identity with the synaptoporin of rat and chicken, respectively. 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KH, Hillstrom HJ, Halpern BC (2015) State-of-the-art management of knee osteoarthritis. World J Clin Cases 3(2):89–101. https:\u002F\u002Fdoi.org\u002F10.12998\u002Fwjcc.v3.i2.89\nMarch LM, Bagga H (2004) Epidemiology of osteoarthritis in Australia. Med J Aust 180(S5):S6-10. https:\u002F\u002Fdoi.org\u002F10.5694\u002Fj.1326-5377.2004.tb05906.x\nXiong G, Wang S, Pan Z, Liu N, Zhao D, Zha Z et al (2022) Long non-coding RNA MEG3 regulates the progress of osteoarthritis by regulating the miR-34a\u002FKlotho axis. Ann Transl Med 10(8):454. https:\u002F\u002Fdoi.org\u002F10.21037\u002Fatm-22-894\nZhou X, Yuan P, Liu Q, Liu Z (2017) LncRNA MEG3 regulates imatinib resistance in chronic myeloid leukemia via suppressing MicroRNA-21. Biomol Ther 25(5):490–496. https:\u002F\u002Fdoi.org\u002F10.4062\u002Fbiomolther.2016.162\nHuang Y, Chen D, Yan Z, Zhan J, Xue X, Pan X et al (2021) LncRNA MEG3 protects chondrocytes from IL-1beta-Induced inflammation via regulating miR-9-5p\u002FKLF4 Axis. Front Physiol 12:617654. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphys.2021.617654\nWang A, Hu N, Zhang Y, Chen Y, Su C, Lv Y et al (2019) MEG3 promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-361-5p\u002FFOXO1 axis. BMC Med Genomics 12(1):201. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12920-019-0649-6\nSu L, Wang Y, Bao Y, Liu X, Xu H (2020) LncRNA MEG3 promotes recovery of knee osteoarthritis in rats through regulating VEGF expression. Panminerva Med. https:\u002F\u002Fdoi.org\u002F10.23736\u002FS0031-0808.19.03832-1\nMiao Y, Chen Y, Xue F, Liu K, Zhu B, Gao J et al (2022) Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression. EBioMedicine 76:103847. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ebiom.2022.103847\nGuo Z, Lin J, Sun K, Guo J, Yao X, Wang G et al (2022) Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway. Front Pharmacol 13:791376. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphar.2022.791376\nWang X, Liu Z, Peng P, Gong Z, Huang J, Peng H (2022) Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes. Chem Biol Interact 366:110148. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cbi.2022.110148\nMa Q, Dai X, Lu W, Qu X, Liu N, Zhu C (2021) Silencing long non-coding RNA MEG8 inhibits the proliferation and induces the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p\u002FNOTCH2 axis. Biochem Biophys Res Commun 556:72–78. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bbrc.2021.03.132\nYan J, Feng G, Ma L, Chen Z, Jin Q (2022) Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis. J Orthop Surg Res 17(1):333. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13018-022-03225-y\nXu C, Ni S, Xu N, Yin G, Yu Y, Zhou B et al (2022) Theaflavin-3,3’-digallate inhibits erastin-induced chondrocytes ferroptosis via the Nrf2\u002FGPX4 signaling pathway in osteoarthritis. Oxid Med Cell Longev 2022:3531995. https:\u002F\u002Fdoi.org\u002F10.1155\u002F2022\u002F3531995\nXu J, Xu Y (2017) The lncRNA MEG3 downregulation leads to osteoarthritis progression via miR-16\u002FSMAD7 axis. Cell Biosci 7:69. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13578-017-0195-x\nChen K, Zhu H, Zheng MQ, Dong QR (2021) LncRNA meg3 inhibits the degradation of the extracellular matrix of chondrocytes in osteoarthritis via targeting miR-93\u002FTGFBR2 axis. Cartilage 13(2):1274S-1284S. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1947603519855759\nAl-Hetty H, Abdulameer SJ, Alghazali MW, Sheri FS, Saleh MM, Jalil AT (2023) The role of ferroptosis in the pathogenesis of osteoarthritis. J Membr Biol. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00232-023-00282-0\nWang X, Liu T, Qiu C, Yu S, Zhang Y, Sheng Y et al (2023) Characterization and role exploration of ferroptosis-related genes in osteoarthritis. Front Mol Biosci 10:1066885. https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmolb.2023.1066885\nSun K, Hou L, Guo Z, Wang G, Guo J, Xu J et al (2023) JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. Free Radic Biol Med 200:87–101. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.freeradbiomed.2023.03.008\nHe Q, Yang J, Pan Z, Zhang G, Chen B, Li S et al (2023) Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2\u002FSystem xc-\u002FGPX4 axis. Biomed Pharmacother 157:113915. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biopha.2022.113915\nWan Y, Shen K, Yu H, Fan W (2023) Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis. Free Radic Biol Med 196:108–120. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.freeradbiomed.2023.01.006\nGong Z, Wang Y, Li L, Li X, Qiu B, Hu Y (2023) Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway. Food Chem Toxicol 174:113644. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.fct.2023.113644\nJin Y, Xu M, Zhu H, Dong C, Ji J, Liu Y et al (2021) Therapeutic effects of bone marrow mesenchymal stem cells-derived exosomes on osteoarthritis. J Cell Mol Med 25(19):9281–9294. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjcmm.16860\nLi X, Tang C, Wang J, Guo P, Wang C, Wang Y et al (2018) Methylene blue relieves the development of osteoarthritis by upregulating lncRNA MEG3. Exp Ther Med 15(4):3856–3864. https:\u002F\u002Fdoi.org\u002F10.3892\u002Fetm.2018.5918",{"EN":1560},"Ferroptosis is involved in osteoarthritis development; however, the roles of long noncoding RNAs (lncRNAs), including lncRNA MEG3, in the regulation of ferroptosis in osteoarthritis are still unclear. In this study, qRT‒PCR and Western blotting assays were used to detect the expression of lncRNA MEG3, miR-885-5p, SLC7A11 and GPX4; MDA and CCK-8 assays were applied to analyse cellular MDA levels and cell viability, respectively. Erastin elevated cellular MDA levels and decreased the viability of chondrocytes and the erastin-induced decline in cell viability was reversed by a ferroptosis inhibitor (ferrostatin-1). Erastin downregulated lncRNA MEG3, SLC7A11 and GPX4 and upregulated miR-885-5p. Silencing of lncRNA MEG3 increased miR-885-5p and downregulated SLC7A11 and GPX4 and further sensitized chondrocytes to erastin-induced ferroptosis. In contrast, overexpression of lncRNA MEG3 had opposite effects. Dual luciferase assays confirmed binding between lncRNA MEG3 and miR-885-5p and between miR-885-5p and the 3′UTR of SLC7A11. In the synovial fluids from patients with osteoarthritis compared with synovial fluids from normal controls, the RNA levels of lncRNA MEG3 and SLC7A11 were decreased and the miR-885-5p expression level was increased. Our findings indicated that lncRNA MEG3 overexpression alleviated ferroptosis in chondrocytes by affecting the miR-885-5p\u002FSLC7A11 signalling pathway.",{"EN":1562},"LncRNA MEG3 suppresses erastin-induced ferroptosis of chondrocytes via regulating miR-885-5p\u002FSLC7A11 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