[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"\"}":3,"_public_publisher_byId_1507fcc5-89ce-4fff-82f8-7f223f89e328":656,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"totalCitation\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:1507fcc5-89ce-4fff-82f8-7f223f89e328,\"}":821},{"meta":4,"data":6},{"total":5},"117",[7,60,176,207,299,413,445,480,543,572],{"id":8,"createTime":9,"updateTime":10,"relativeEntities":11,"slug":12,"properties":13,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":29,"subjectFields":30,"manageAffiliations":31,"indexDatabases":32,"url":33,"thumbnailPath":34,"statistic":35,"gsStatistic":26,"type":26,"analyzePriority":26},"5a09599f-54d1-44c3-8f16-3847ac552024","2023-08-17T04:28:50.832+00:00","2025-10-13T23:58:52.517+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Truy%E1%BB%81n-nhi%E1%BB%85m-Vi%E1%BB%87t-Nam",{"country":14,"issn":16,"introduce":18,"title":21},{"VOID":15},"VN",{"VOID":17},"08667829",{"EN":19,"VI":20},"{\"ops\":[{\"insert\":\"Vietnam Journal of Infectious Diseases is a social - professional forum of the Vietnam Society for Infectious Diseases, whose responsibility is to introduce the researches, the scientific advances in Vietnam and from the world; to contribute to the improvement of knowledges for health care staffs about clinic, treatment, guideline, prevention, epidemiology for infectious diseases, HIV\u002FAIDS and community health care; to provide, exchange and publish scientific information to the public accurately and promptly.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Vietnam Journal of Infectious Diseases publishes in the whole country; serves the professional work for researchers, clinical staffs, administrators, undergraduate and postgraduate students who are working and studying in the infections, tropical diseases and HIV\u002FAIDS from central to local levels, also organizations and individuals in the world who are interested in infectious and tropical diseases and prevention for HIV\u002FAIDS.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Editor in Chief:\"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"insert\":\"Prof. Dr. Nguyen Van Kinh. - Chairman of Editorial Board\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"Prof. Dr. Nguyen Van Mui.\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Headquarter:\"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Address:\"},{\"insert\":\" Level 6, National Hospital for Tropical Diseases, No. 78 Giai Phong Street, Dong Da District, Hanoi city, Vietnam.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Tel:\"},{\"insert\":\" \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:02435765464\"},\"insert\":\"02435765464\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913552672\"},\"insert\":\"0913552672\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913228072\"},\"insert\":\"0913228072\"},{\"insert\":\".\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Email\"},{\"insert\":\": \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Findex\u002Fadmin\u002Fcontexts\u002Fmailto:tungphamvan52@gmail.com\"},\"insert\":\"tungphamvan52@gmail.com\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Fmailto:tapchitruyennhiem@gmail.com\"},\"insert\":\"tapchitruyennhiem@gmail.com\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Bank account:\"},{\"insert\":\" 0021000275119, Vietcombank Hanoi Branch. Transaction office No. 7, 402 Tran Khat Chan, Hai Ba Trung District, Hanoi city, Vietnam.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Tạp chí Truyền nhiễm Việt Nam là cơ quan ngôn luận của Hội Truyền nhiễm Việt Nam, chịu sự lãnh đạo, chỉ đạo trực tiếp của Thường vụ Ban Chấp hành Hội Truyền nhiễm Việt Nam; sự kiểm tra, giám sát về nghiệp vụ báo chí của các cơ quan chức năng quản lý báo chí thuộc Bộ Thông tin và Truyền thông và Ban Tuyên giáo Trung ương Đảng.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí có trách nhiệm giới thiệu các công trình nghiên cứu khoa học, những tiến bộ khoa học trên thế giới và trong nước, góp phần nâng cao kiến thức khoa học cho cán bộ y tế về lâm sàng, điều trị, hướng dẫn, dự phòng, dịch tễ học các bệnh truyền nhiễm, HIV\u002FAIDS và chăm sóc sức khỏe cộng đồng; cung cấp, trao đổi, phổ biến các thông tin khoa học tới công chúng chính xác và kịp thời.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí xuất bản 03 tháng\u002F01 kỳ và được phát hành qua Bưu điện và tự phát hành trong phạm vi toàn quốc.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Lãnh đạo Tạp chí: \"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"insert\":\"Tổng Biên tập: ThS.BSCKII Nguyễn Trung Cấp\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"Phó Tổng Biên tập:\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"            TS.BSCKII Phạm Ngọc Thạch\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Trụ sở tòa soạn:\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Địa chỉ: Tầng 6, Bệnh viện Bệnh Nhiệt đới Trung ương, 78 đường Giải Phóng, phường Phương Mai, quận Đống Đa, thành phố Hà Nội.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Điện thoại:\"},{\"insert\":\" \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:02435765464\"},\"insert\":\"02435765464\"},{\"insert\":\" - \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913228072\"},\"insert\":\"0913228072\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Email\"},{\"insert\":\": \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Findex\u002Fadmin\u002Fcontexts\u002Fmailto:tungphamvan52@gmail.com\"},\"insert\":\"tungphamvan52@gmail.com\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Fmailto:tapchitruyennhiem@gmail.com\"},\"insert\":\"tapchitruyennhiem@gmail.com\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Tài khoản:\"},{\"insert\":\" Số 0021000275119 Ngân hàng Ngoại thương Việt Nam, chi nhánh Hà Nội (Vietcombank Hà Nội). Phòng giao dịch số 7, 402 Trần Khát Chân, quận Hai Bà Trưng, Thành phố Hà Nội.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}",{"EN":22,"VI":23},"Vietnam Journal of Infectious Diseases","Tạp chí Truyền nhiễm Việt Nam","PUBLISHER","VERIFIED",null,"Admin update database","PENDING",51,[],[],[],"https:\u002F\u002Ftruyennhiemvietnam.vn\u002Findex.php\u002Fvjid","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F5a09599f-54d1-44c3-8f16-3847ac552024\u002Fadb0e52bf25e0de580fd4289519cb8bf.jpg",{"impactFactor":36,"impactFactorByYear":37,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":41,"totalPublicationByYear":42,"totalCitation":48,"totalCitationByYear":49,"totalCitationPerPublication":54,"totalCitationPerPublicationByYear":55,"hindexLast5Year":59,"hindex":59},0,{"2022":38,"2023":39,"2024":40},0.01,0.03,0.13,315,{"2020":43,"2021":44,"2022":45,"2023":46,"2024":47},63,58,57,65,72,43,{"2020":50,"2021":51,"2022":52,"2023":53},8,15,9,11,0.14,{"2020":40,"2021":56,"2022":57,"2023":58},0.26,0.16,0.17,3,{"id":61,"createTime":62,"updateTime":63,"relativeEntities":64,"slug":65,"properties":66,"entityType":24,"verifyStatus":25,"verifyTime":78,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":79,"subjectFields":80,"manageAffiliations":81,"indexDatabases":136,"url":137,"thumbnailPath":26,"statistic":138,"gsStatistic":155,"type":175,"analyzePriority":26},"25b6bd10-676c-40c0-8dc3-356d1679a284","2023-05-19T02:22:33.430+00:00","2026-06-18T23:33:57.141+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Y-D%C6%B0%E1%BB%A3c-h%E1%BB%8Dc-C%E1%BA%A7n-Th%C6%A1",{"country":67,"issn":68,"introduce":70,"title":73,"gsId":76},{"VOID":15},{"VOID":69},"23541210",{"EN":71,"VI":72},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"EN":74,"VI":75},"Cantho Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"VOID":77},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",32,[],[82],{"id":83,"createTime":84,"updateTime":85,"relativeEntities":86,"slug":87,"properties":88,"entityType":98,"verifyStatus":25,"verifyTime":99,"verifyNote":26,"syncStatus":28,"languages":100,"translateLanguages":26,"viewCount":103,"url":104,"parentIds":105,"statistic":106},"6413896b-eca9-442b-a73f-182a58a0ce40","2023-06-12T14:59:13.446+00:00","2026-06-19T02:29:32.871+00:00",[],"Tr%C6%B0%E1%BB%9Dng-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Y-D%C6%B0%E1%BB%A3c-C%E1%BA%A7n-Th%C6%A1",{"country":89,"title":90,"address":93,"abbreviation":96},{"VOID":15},{"EN":91,"VI":92},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"VI":94,"EN":95},"Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam","No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam",{"VOID":97},"ctump","AFFILIATION","2023-08-01T14:07:27.977+00:00",[101,102],"VI","EN",12,"http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":107,"i10Index":111,"i10IndexLast5Year":59,"totalPublication":112,"totalPublicationByYear":113,"totalCitation":122,"totalCitationByYear":123,"totalCitationPerPublication":128,"totalCitationPerPublicationByYear":129,"hindexLast5Year":135,"hindex":135},{"2022":108,"2023":109,"2024":110,"2025":38},0.1,0.05,0.07,4,1489,{"2013":114,"2014":115,"2015":115,"2016":111,"2017":115,"2018":59,"2019":114,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120,"2025":121,"2026":111},2,1,10,84,281,680,260,156,313,{"2013":59,"2014":114,"2018":124,"2021":125,"2022":126,"2023":127},17,36,123,132,0.21,{"2013":130,"2014":114,"2018":131,"2021":132,"2022":133,"2023":134},1.5,5.67,0.43,0.44,0.19,6,[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":36,"impactFactorByYear":139,"i10Index":114,"i10IndexLast5Year":114,"totalPublication":140,"totalPublicationByYear":141,"totalCitation":147,"totalCitationByYear":148,"totalCitationPerPublication":151,"totalCitationPerPublicationByYear":152,"hindexLast5Year":135,"hindex":135},{"2022":38,"2023":36,"2024":39,"2025":38},1956,{"0":114,"2019":114,"2020":50,"2021":142,"2022":143,"2023":144,"2024":145,"2025":146},76,403,789,305,371,524,{"0":114,"2019":135,"2021":124,"2022":149,"2023":150,"2024":111,"2025":114},287,206,0.27,{"0":115,"2019":59,"2021":153,"2022":154,"2023":56,"2024":38,"2025":38},0.22,0.71,{"impactFactor":26,"impactFactorByYear":26,"i10Index":114,"i10IndexLast5Year":114,"totalPublication":156,"totalPublicationByYear":157,"totalCitation":163,"totalCitationByYear":164,"totalCitationPerPublication":169,"totalCitationPerPublicationByYear":170,"hindexLast5Year":135,"hindex":135},461,{"0":158,"2019":114,"2021":159,"2022":160,"2023":161,"2024":158,"2025":162},7,37,296,107,5,419,{"2021":59,"2022":59,"2023":165,"2024":166,"2025":167,"2026":168},71,126,171,41,0.91,{"2021":171,"2022":38,"2023":172,"2024":173,"2025":174},0.08,0.66,18,34.2,"JOURNAL",{"id":177,"createTime":178,"updateTime":179,"relativeEntities":180,"slug":181,"properties":182,"entityType":24,"verifyStatus":25,"verifyTime":193,"verifyNote":26,"syncStatus":28,"languages":194,"translateLanguages":26,"viewCount":36,"subjectFields":195,"manageAffiliations":196,"indexDatabases":197,"url":198,"thumbnailPath":26,"statistic":26,"gsStatistic":199,"type":175,"analyzePriority":26},"f8d0bf97-8d89-482e-b58c-2fc481a0b79b","2025-10-27T06:27:08.591+00:00","2026-06-18T23:33:41.667+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-v%C3%A0-C%C3%B4ng-ngh%E1%BB%87-nhi%E1%BB%87t-%C4%91%E1%BB%9Bi",{"country":183,"introduce":184,"gsId":186,"title":188,"issn":191},{"VOID":15},{"EN":185},"\u003Cp style=\"text-align:justify;\">     Journal of Tropical Science and Engineering (JTSE) is a multidisciplinary scientific journal, licensed to operate as a print journal in 2012 and an electronic journal in 2024 (License No.1479\u002FGP-BTTTT dated August 20, 2012 and No.91\u002FGP-BTTTT dated April 9, 2024 issued by the Ministry of Information and Communications of Vietnam). The JTSE is headquartered in Hanoi.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">        The JTSE is published every 3 months (4 issues\u002Fyear), publishing research results and overview articles in 3 groups of fields: Tropical Ecology and Environment; Chemistry and Material Sciences; Biomedicine and Pharmacy. In 2022, the JTSE registered the international identifier Digital Object Identifier (DOI): 10.58334\u002Fvrtc.jtst and assigned DOI codes to all articles of the journal. The members of the Editorial Board of the JTSE are prestigious scientists and leading scientists from Vietnam and many countries in the world. The JTSE has been recognized by the Vietnam State Council for Professorship to score scientific articles in Chemistry, Medicine and Biology with scores ranging from 0-0.75 points.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">      Currently, the JTSE is building and perfecting a set of criteria and making efforts to join the List of prestigious  international journals with a roadmap to enter Scopus and SCIE in the coming time.\u003C\u002Fp>",{"VOID":187},"MS2_GJQAAAAJ",{"VI":189,"EN":190},"Tạp chí Khoa học và Công nghệ nhiệt đới","Journal of Tropical Science and Engineering",{"VOID":192},"08667535","2025-10-27T06:27:25.058+00:00",[101,102],[],[],[],"https:\u002F\u002Ftapchikhcnnd.com.vn",{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":200,"totalPublicationByYear":201,"totalCitation":161,"totalCitationByYear":203,"totalCitationPerPublication":153,"totalCitationPerPublicationByYear":205,"hindexLast5Year":114,"hindex":114},481,{"0":115,"2020":115,"2021":115,"2022":114,"2024":115,"2025":202,"2026":115},474,{"2017":114,"2018":115,"2019":111,"2020":162,"2021":162,"2022":116,"2023":50,"2024":162,"2025":204,"2026":52},52,{"2020":162,"2021":162,"2022":162,"2024":162,"2025":206,"2026":52},0.11,{"id":208,"createTime":209,"updateTime":210,"relativeEntities":211,"slug":212,"properties":213,"entityType":24,"verifyStatus":25,"verifyTime":221,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":222,"subjectFields":223,"manageAffiliations":224,"indexDatabases":225,"url":226,"thumbnailPath":26,"statistic":227,"gsStatistic":276,"type":175,"analyzePriority":26},"a3d1e82a-57e2-40f9-940e-f5fa8b9ef64a","2023-06-01T07:11:26.039+00:00","2026-06-18T23:33:28.573+00:00",[],"VNU-Journal-of-Science-Earth-and-Environmental-Sciences",{"issn":214,"title":216,"country":218,"gsId":219},{"VOID":215},"26159279",{"EN":217},"VNU Journal of Science: Earth and Environmental Sciences",{"VOID":15},{"VOID":220},"UmXD8vEAAAAJ","2023-06-01T07:17:59.210+00:00",27,[],[],[],"https:\u002F\u002Fjs.vnu.edu.vn\u002FEES",{"impactFactor":36,"impactFactorByYear":228,"i10Index":234,"i10IndexLast5Year":36,"totalPublication":235,"totalPublicationByYear":236,"totalCitation":246,"totalCitationByYear":247,"totalCitationPerPublication":261,"totalCitationPerPublicationByYear":262,"hindexLast5Year":103,"hindex":103},{"2010":229,"2012":40,"2013":230,"2014":230,"2015":231,"2016":54,"2017":171,"2018":109,"2019":110,"2020":57,"2021":232,"2022":233,"2023":151,"2024":58},0.02,0.04,0.09,0.31,0.4,19,656,{"2008":237,"2009":238,"2010":239,"2011":238,"2012":240,"2013":241,"2014":239,"2015":242,"2016":243,"2017":244,"2018":245,"2019":165,"2020":125,"2021":168,"2022":125,"2023":222,"2024":111},23,24,22,28,25,20,146,29,78,1038,{"2008":248,"2009":249,"2010":250,"2011":251,"2012":252,"2013":253,"2014":254,"2015":255,"2016":256,"2017":257,"2018":161,"2019":258,"2020":259,"2021":29,"2022":260},119,64,66,86,38,73,59,31,129,39,97,53,26,1.58,{"2008":263,"2009":264,"2010":59,"2011":265,"2012":266,"2013":267,"2014":268,"2015":269,"2016":270,"2017":271,"2018":272,"2019":272,"2020":273,"2021":274,"2022":275},5.17,2.67,3.58,1.36,2.92,2.68,1.55,0.88,1.34,1.37,1.47,1.24,0.72,{"impactFactor":26,"impactFactorByYear":26,"i10Index":173,"i10IndexLast5Year":135,"totalPublication":277,"totalPublicationByYear":278,"totalCitation":279,"totalCitationByYear":280,"totalCitationPerPublication":288,"totalCitationPerPublicationByYear":289,"hindexLast5Year":158,"hindex":298},113,{"2007":114,"2008":103,"2009":173,"2010":116,"2011":51,"2012":239,"2013":103,"2014":162,"2015":53,"2016":135},616,{"2009":162,"2010":114,"2011":52,"2012":124,"2013":222,"2014":255,"2015":48,"2016":44,"2017":281,"2018":282,"2019":259,"2020":283,"2021":284,"2022":285,"2023":286,"2024":257,"2025":287,"2026":59},54,60,49,47,34,44,33,5.45,{"2009":290,"2010":291,"2011":292,"2012":293,"2013":294,"2014":295,"2015":296,"2016":297},0.28,0.2,0.6,0.77,2.25,6.2,3.91,9.67,14,{"id":300,"createTime":301,"updateTime":302,"relativeEntities":303,"slug":304,"properties":305,"entityType":24,"verifyStatus":25,"verifyTime":316,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":234,"subjectFields":317,"manageAffiliations":318,"indexDatabases":388,"url":389,"thumbnailPath":390,"statistic":391,"gsStatistic":409,"type":175,"analyzePriority":26},"a7166325-6c9e-4db3-8a59-7c879701a372","2023-07-31T04:28:49.231+00:00","2026-06-18T23:33:22.428+00:00",[],"VNU-Journal-of-Science-Policy-and-Management-Studies",{"country":306,"issn":307,"eissn":309,"title":311,"gsId":314},{"VOID":15},{"VOID":308},"26159295",{"VOID":310},"25881116",{"EN":312,"VI":313},"VNU Journal of Science: Policy and Management Studies","Tạp chí Nghiên cứu Chính sách và Quản lý",{"VOID":315},"xKW2E_cAAAAJ","2023-08-01T03:23:46.688+00:00",[],[319],{"id":320,"createTime":321,"updateTime":322,"relativeEntities":323,"slug":324,"properties":325,"entityType":98,"verifyStatus":25,"verifyTime":335,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":336,"url":337,"parentIds":338,"statistic":339},"12466116-8f60-4b01-8faf-2411483a0977","2023-05-30T09:37:38.472+00:00","2026-06-19T02:14:28.352+00:00",[],"Vietnam-National-University",{"country":326,"title":327,"abbreviation":330,"address":332},{"VOID":15},{"EN":328,"VI":329},"Vietnam National University, Hanoi","Đại học Quốc gia Hà Nội",{"VOID":331},"VNU",{"VI":333,"EN":334},"Số 144 Xuân Thủy, Phường Dịch Vọng Hậu, Quận Cầu Giấy, Hà Nội, Việt Nam","No. 144 Xuan Thuy Street, Dich Vong Hau Ward, Cau Giay District, Hanoi, Vietnam","2023-08-02T13:58:17.029+00:00",16,"http:\u002F\u002Fwww.vnu.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":340,"i10Index":285,"i10IndexLast5Year":162,"totalPublication":344,"totalPublicationByYear":345,"totalCitation":354,"totalCitationByYear":355,"totalCitationPerPublication":368,"totalCitationPerPublicationByYear":369,"hindexLast5Year":336,"hindex":336},{"2014":109,"2015":231,"2016":231,"2017":206,"2018":341,"2019":110,"2020":342,"2021":343,"2022":171,"2023":231,"2024":110,"2025":39},0.06,0.18,0.35,1247,{"2003":115,"2004":115,"2005":114,"2006":59,"2007":111,"2008":162,"2009":59,"2010":50,"2011":124,"2012":336,"2013":260,"2014":244,"2015":250,"2016":281,"2017":346,"2018":347,"2019":348,"2020":349,"2021":350,"2022":351,"2023":352,"2024":353,"2025":255,"2026":50},94,88,83,67,176,185,187,93,1644,{"2004":111,"2005":115,"2006":52,"2007":298,"2008":356,"2009":298,"2010":286,"2011":357,"2012":244,"2013":358,"2014":359,"2015":360,"2016":361,"2017":362,"2018":363,"2019":364,"2020":365,"2021":366,"2022":367,"2023":367,"2024":162},13,81,48,70,151,115,109,259,174,181,121,101,1.32,{"2004":111,"2005":370,"2006":59,"2007":371,"2008":372,"2009":373,"2010":374,"2011":375,"2012":376,"2013":377,"2014":378,"2015":379,"2016":380,"2017":381,"2018":382,"2019":383,"2020":384,"2021":385,"2022":386,"2023":387,"2024":109},0.5,3.5,2.6,4.67,5.5,4.76,1.81,1.85,2.41,2.29,2.13,1.16,2.94,2.1,2.7,0.69,0.55,0.54,[],"https:\u002F\u002Fjs.vnu.edu.vn\u002FPaM","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002Fa7166325-6c9e-4db3-8a59-7c879701a372\u002Fecfe83f4bcc60c7023ae04d8900fe0ac.jpg",{"impactFactor":36,"impactFactorByYear":392,"i10Index":111,"i10IndexLast5Year":36,"totalPublication":394,"totalPublicationByYear":395,"totalCitation":399,"totalCitationByYear":400,"totalCitationPerPublication":293,"totalCitationPerPublicationByYear":403,"hindexLast5Year":158,"hindex":158},{"2018":109,"2019":171,"2020":393,"2021":108,"2022":54,"2023":206,"2024":54},0.23,320,{"2015":50,"2016":239,"2017":286,"2018":396,"2019":397,"2020":159,"2021":398,"2022":168,"2023":79,"2024":255},30,35,40,247,{"2015":115,"2016":242,"2017":401,"2018":222,"2019":402,"2020":79,"2021":239,"2022":50,"2023":116},77,50,{"2015":404,"2016":169,"2017":405,"2018":406,"2019":407,"2020":408,"2021":386,"2022":291,"2023":232},0.12,1.75,0.9,1.43,0.86,{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":103,"totalPublicationByYear":410,"totalCitation":234,"totalCitationByYear":411,"totalCitationPerPublication":261,"totalCitationPerPublicationByYear":412,"hindexLast5Year":114,"hindex":59},{"2015":114,"2016":116},{"2016":115,"2017":114,"2018":114,"2019":59,"2020":114,"2021":59,"2022":114,"2023":114,"2024":115,"2026":115},{"2016":108},{"id":414,"createTime":415,"updateTime":416,"relativeEntities":417,"slug":418,"properties":419,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":238,"subjectFields":428,"manageAffiliations":429,"indexDatabases":430,"url":431,"thumbnailPath":26,"statistic":432,"gsStatistic":438,"type":175,"analyzePriority":26},"16e65a3f-d274-47dd-8691-56d76eb58c3d","2023-05-30T09:10:06.062+00:00","2026-06-18T23:33:17.679+00:00",[],"Vietnam-Journal-of-Otorhinolaryngology-Head-and-Neck-Surgery",{"country":420,"issn":421,"title":423,"gsId":426},{"VOID":15},{"VOID":422},"18593704",{"EN":424,"VI":425},"Vietnam Journal of Otorhinolaryngology - Head and Neck Surgery","Tạp chí Tai Mũi Họng Việt Nam",{"VOID":427},"L78B_eIAAAAJ",[],[],[],"https:\u002F\u002Ftapchitaimuihong.vn\u002Findex.php\u002Ftmh",{"impactFactor":36,"impactFactorByYear":433,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":434,"totalPublicationByYear":435,"totalCitation":111,"totalCitationByYear":436,"totalCitationPerPublication":230,"totalCitationPerPublicationByYear":437,"hindexLast5Year":115,"hindex":115},{"2024":229},95,{"2022":52,"2023":286,"2024":255,"2025":53},{"2023":111},{"2023":231},{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":240,"totalPublicationByYear":439,"totalCitation":234,"totalCitationByYear":440,"totalCitationPerPublication":441,"totalCitationPerPublicationByYear":442,"hindexLast5Year":114,"hindex":114},{"2023":53,"2024":116,"2025":135,"2026":115},{"2024":59,"2025":298,"2026":114},0.68,{"2024":443,"2025":444,"2026":114},0.3,2.33,{"id":446,"createTime":447,"updateTime":448,"relativeEntities":449,"slug":450,"properties":451,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":396,"subjectFields":460,"manageAffiliations":461,"indexDatabases":462,"url":463,"thumbnailPath":464,"statistic":465,"gsStatistic":472,"type":175,"analyzePriority":26},"25988add-c322-4eda-afda-63b1559bb824","2023-04-07T03:49:55.817+00:00","2026-06-18T23:32:23.776+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Y%20-%20D%C6%B0%E1%BB%A3c%20h%E1%BB%8Dc%20qu%C3%A2n%20s%E1%BB%B1",{"country":452,"issn":453,"title":455,"gsId":458},{"VOID":15},{"VOID":454},"18590748",{"EN":456,"VI":457},"Journal of Military Pharmaco-medicine","Tạp chí Y - Dược học quân sự",{"VOID":459},"_pmQ8IEAAAAJ",[],[],[],"https:\u002F\u002Fjmpm.vn\u002Findex.php\u002Fjmpm","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F25988add-c322-4eda-afda-63b1559bb824\u002F09c6bc42157cf5ece95edc971ccddb52.jpg",{"impactFactor":36,"impactFactorByYear":466,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":467,"totalPublicationByYear":468,"totalCitation":135,"totalCitationByYear":470,"totalCitationPerPublication":38,"totalCitationPerPublicationByYear":471,"hindexLast5Year":115,"hindex":115},{"2023":229,"2024":38},475,{"2022":168,"2023":365,"2024":469,"2025":124},236,{"2022":114,"2023":111},{"2022":109,"2023":229},{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":277,"totalPublicationByYear":473,"totalCitation":401,"totalCitationByYear":474,"totalCitationPerPublication":441,"totalCitationPerPublicationByYear":475,"hindexLast5Year":59,"hindex":59},{"2015":115,"2018":114,"2019":115,"2020":115,"2021":59,"2022":103,"2023":159,"2024":287,"2025":237},{"2020":115,"2021":115,"2022":115,"2023":52,"2024":237,"2025":79,"2026":116},{"2020":115,"2021":476,"2022":171,"2023":477,"2024":478,"2025":479},0.33,0.24,0.7,1.39,{"id":481,"createTime":482,"updateTime":483,"relativeEntities":484,"slug":485,"properties":486,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":496,"translateLanguages":26,"viewCount":45,"subjectFields":497,"manageAffiliations":498,"indexDatabases":525,"url":526,"thumbnailPath":527,"statistic":528,"gsStatistic":26,"type":26,"analyzePriority":26},"2b8d7b12-2d20-4777-be98-077f44f03c69","2023-09-07T07:40:58.286+00:00","2025-07-13T21:21:00.542+00:00",[],"VNU-Journal-of-Social-Sciences-and-Humanities",{"country":487,"issn":488,"introduce":490,"title":493},{"VOID":15},{"VOID":489},"23541172",{"EN":491,"VI":492},"{\"ops\":[{\"insert\":\"VNU Journal of Social Sciences and Humanities (ISSN 2354-1172) is a double-blind peer-reviewed journal published by University of Social Sciences and Humanities, Vietnam National University, Hanoi, Vietnam, under the publication permit no. 155\u002FGP-BTTTT, issued on 11\"},{\"attributes\":{\"script\":\"super\"},\"insert\":\"th \"},{\"insert\":\"May, 2015 by Ministry of Information and Communications. The journal publishes four Vietnamese issues and two English issues per year.\\nCurrently, there are 35 reputable professors in the editorial board. The main objectives of the journal include: providing an intellectual platform for Vietnamese and international scholars; promoting interdisciplinary studies in social sciences and humanities; becoming the leading journal in social sciences and humanities in Vietnam; being indexed by worldwide databases and having academic recognition internationally in the near future.\\nThe journal is currently indexed by Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services and Vietnam National University’s digital archive.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Journal of Social Sciences and Humanities-Vietnam\"},{\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"ISSN 2354-1172, email: tapchikhxhnv@gmail.com, tckhxhnv@vnu.edu.vn\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Được thành lập ngày 31\u002F8\u002F2015 (giấy phép hoạt động số 155\u002FGP-BVHTT ngày 11 tháng 5 năm 2015 của Bộ Thông tin và Truyền thông, mã số tiêu chuẩn quốc tế ISSN 2354-1172), Tạp chí Khoa học Xã hội và Nhân văn (Journal of Social Sciences and Humanities) là ấn phẩm khoa học chính thức, duy nhất của Trường Đại học Khoa học Xã hội và Nhân văn, ĐHQG Hà Nội, phát triển và kế thừa Chuyên san Khoa học Xã hội và Nhân văn, Tạp chí Khoa học, ĐHQG Hà Nội.\\nTạp chí xuất bản định kỳ (04 số tiếng Việt\u002Fnăm và 02 số tiếng Anh\u002Fnăm), có nhiệm vụ \"},{\"attributes\":{\"italic\":true},\"insert\":\"công bố, giới thiệu các công trình nghiên cứu khoa học khoa học xã hội và nhân văn của các tác giả là các nhà khoa học trong và ngoài nước, phục vụ giảng dạy, học tập và nghiên cứu khoa học\"},{\"insert\":\". Hội đồng biên tập của Tạp chí hiện bao gồm 33 nhà khoa học có uy tín trong nước và quốc tế. Tạp chí tập trung và ưu tiên đăng tải những bài báo theo định hướng của tinh thần cởi mở, sáng tạo, nhanh chóng vươn lên để tiếp cận và sánh ngang với các tạp chí có uy tín hàng đầu của khu vực và trên thế giới. Nội dung chính của Tạp chí bao gồm các Bài nghiên cứu (khoảng 6000 đến 15000 từ), các bài điểm sách, thông tin khoa học (khoảng 300 đến 1500 từ) được trình bày theo đúng cấu trúc và chuẩn mực của một tạp chí khoa học.\\nCác bài viết của Tạp chí hiện đang được trích dẫn bởi Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services.\\nMọi thông tin xin liên hệ: \"},{\"attributes\":{\"italic\":true},\"insert\":\"Phòng Tạp chí, 701 - E, Trường Đại học Khoa học Xã hội và Nhân văn, 336 Nguyễn Trãi, Thanh Xuân, Hà Nội. ĐT: 024.35581984; email: tckhxhnv@vnu.edu.vn \"},{\"insert\":\"hoặc \"},{\"attributes\":{\"italic\":true},\"insert\":\"tapchikhxhnv@gmail.com \"},{\"insert\":\"\\n\"}]}",{"EN":494,"VI":495},"VNU Journal of Social Sciences and Humanities","Tạp chí Khoa học Xã hội và Nhân văn",[101,102],[],[499],{"id":500,"createTime":501,"updateTime":502,"relativeEntities":503,"slug":504,"properties":505,"entityType":98,"verifyStatus":25,"verifyTime":509,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":222,"url":26,"parentIds":510,"statistic":511},"8b6e349b-0daf-4895-9c3f-85f30f1bfd42","2023-07-31T12:55:58.430+00:00","2026-06-19T02:30:07.899+00:00",[],"Tr%C6%B0%E1%BB%9Dng-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Khoa-h%E1%BB%8Dc-X%C3%A3-h%E1%BB%99i-v%C3%A0-Nh%C3%A2n-v%C4%83n-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-H%C3%A0-N%E1%BB%99i",{"title":506},{"EN":507,"VI":508},"VNU University of Social Sciences and Humanities","Trường Đại học Khoa học Xã hội và Nhân văn, Đại học Quốc gia Hà Nội","2023-08-02T15:28:49.057+00:00",[],{"impactFactor":36,"impactFactorByYear":512,"i10Index":59,"i10IndexLast5Year":115,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":518,"totalCitationByYear":519,"totalCitationPerPublication":520,"totalCitationPerPublicationByYear":521,"hindexLast5Year":162,"hindex":162},{"2016":229,"2017":230,"2018":229,"2021":230,"2022":58,"2023":513,"2024":38},0.15,365,{"2013":115,"2014":158,"2015":125,"2016":252,"2017":44,"2018":516,"2019":286,"2020":396,"2021":259,"2022":517,"2023":396,"2024":115,"2025":59,"2026":115},21,42,169,{"2015":283,"2016":135,"2017":52,"2018":50,"2019":298,"2020":53,"2021":359,"2022":115,"2023":115},0.46,{"2015":266,"2016":57,"2017":57,"2018":522,"2019":523,"2020":524,"2021":368,"2022":229,"2023":39},0.38,0.32,0.37,[],"http:\u002F\u002Fjournal.ussh.vnu.edu.vn\u002Findex.php\u002Fvjossh","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F2b8d7b12-2d20-4777-be98-077f44f03c69\u002F0bd0751202944a4b4165b482e6e623e4.png",{"impactFactor":36,"impactFactorByYear":529,"i10Index":162,"i10IndexLast5Year":115,"totalPublication":530,"totalPublicationByYear":531,"totalCitation":537,"totalCitationByYear":538,"totalCitationPerPublication":343,"totalCitationPerPublicationByYear":540,"hindexLast5Year":135,"hindex":135},{"2016":341,"2017":39,"2018":229,"2019":38,"2020":110,"2021":231,"2022":231,"2023":341,"2024":39},764,{"2015":255,"2016":245,"2017":532,"2018":259,"2019":533,"2020":534,"2021":535,"2022":536,"2023":534,"2024":254,"2025":50},111,106,68,92,89,265,{"2015":539,"2016":241,"2017":168,"2018":51,"2019":349,"2020":260,"2021":244,"2022":298,"2023":114},46,{"2015":541,"2016":523,"2017":524,"2018":290,"2019":542,"2020":522,"2021":523,"2022":57,"2023":39},1.48,0.63,{"id":544,"createTime":545,"updateTime":546,"relativeEntities":547,"slug":548,"properties":549,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":558,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":50,"subjectFields":559,"manageAffiliations":560,"indexDatabases":561,"url":562,"thumbnailPath":563,"statistic":564,"gsStatistic":26,"type":26,"analyzePriority":26},"6ec01bd0-15c0-469a-86ac-41339076ae0a","2023-08-10T07:08:33.153+00:00","2026-01-31T21:19:06.362+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Da-li%E1%BB%85u-h%E1%BB%8Dc-Vi%E1%BB%87t-Nam",{"country":550,"issn":551,"introduce":553,"title":555},{"VOID":15},{"VOID":552},"18594824",{"VI":554},"{\"ops\":[{\"insert\":\"Tạp chí “Da liễu học Việt Nam” (Tiếng Anh: Vietnamese Journal of Dermatology and Venereology) thuộc Hội Da liễu Việt Nam, xuất bản 4 số mỗi năm bằng tiếng Việt hoặc tiếng Anh.\\nTạp chí Da liễu học Việt Nam hoạt động với mục đích, tôn chỉ là phổ biến, trao đổi thông tin trong lĩnh vực chuyên ngành da liễu; đăng tải các công trình nghiên cứu khoa học; chuyển giao công nghệ - kinh tế và khoa học kỹ thuật liên quan đến lĩnh vực da liễu.\\nPhạm vi của tạp chí là tất cả các bài báo khoa học, bài tổng quan, giới thiệu ca lâm sàng, … có liên quan tới chuyên ngành da liễu trong và ngoài nước. Tạp chí công bố các công trình nghiên cứu liên quan đến mô hình bệnh tật, các phương pháp chẩn đoán, điều trị, dự phòng và phục hồi chức năng các bệnh thuộc chuyên ngành da liễu. Ngoài ra, tạp chí còn đăng tải các bài tổng quan, cập nhật thông tin, kiến thức, hướng dẫn chẩn đoán, điều trị trong chuyên ngành da liễu trong nước và quốc tế; đăng tải các bài ca lâm sàng đặc biệt trong chuyên ngành da liễu.\\nTạp chí Da liễu học Việt Nam được biết tới là một tạp chí chuyên ngành có uy tín trong lĩnh vực da liễu. Các bài báo về nghiên cứu khoa học đăng trong Tạp chí được bình duyệt một cách nghiêm ngặt bởi ít nhất 2 chuyên gia. Hội đồng biên tập tạp chí bao gồm các nhà khoa học có uy tín (Giáo sư, Phó Giáo sư, Tiến sĩ, Bác sĩ…) trong chuyên ngành da liễu nhằm đảm bảo chất lượng và tính khách quan, khoa học cho các bài viết đăng trên Tạp chí.\\n\"}]}",{"EN":556,"VI":557},"Vietnamese Journal of Dermatology and Venereology","Tạp chí Da liễu học Việt Nam","Admin Import",[],[],[],"https:\u002F\u002Fvjdv.vn\u002Findex.php\u002Fvjdv","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F6ec01bd0-15c0-469a-86ac-41339076ae0a\u002F3cbc81720e58429dc7b1c4d7ab1935ca.jpg",{"impactFactor":36,"impactFactorByYear":565,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":566,"totalPublicationByYear":567,"totalCitation":116,"totalCitationByYear":570,"totalCitationPerPublication":109,"totalCitationPerPublicationByYear":571,"hindexLast5Year":115,"hindex":115},{"2023":38,"2024":230},182,{"2022":568,"2023":45,"2024":569},69,56,{"2022":52,"2023":115},{"2022":40,"2023":229},{"id":573,"createTime":574,"updateTime":575,"relativeEntities":576,"slug":577,"properties":578,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":587,"translateLanguages":26,"viewCount":283,"subjectFields":588,"manageAffiliations":589,"indexDatabases":647,"url":648,"thumbnailPath":649,"statistic":650,"gsStatistic":26,"type":26,"analyzePriority":26},"19221551-7519-47ff-a892-331d1139c64b","2023-09-12T07:03:05.744+00:00","2026-01-24T20:54:40.144+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-S%E1%BB%A9c-kho%E1%BA%BB-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-Th%C3%A0nh-ph%E1%BB%91-H%E1%BB%93-Ch%C3%AD-Minh",{"country":579,"issn":580,"introduce":582,"title":584},{"VOID":15},{"VOID":581},"27349446",{"EN":583},"{\"ops\":[{\"attributes\":{\"bold\":true},\"insert\":\"1. History\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Science and Technology Development Journal\"},{\"insert\":\" (STDJ) (ISSN 2734-9446), Vietnam National University - Ho Chi Minh City (VNU-HCM) was established in 1997. And the first issue was published in January 1998 with ISSN 1859-0128. Since then, STDJ has become the most important scientific forum of scientists from VNU-HCM as well as other universities. The magazine has undergone 20 years of development and has become a bridge for scientific exchanges, as well as enriching reference materials for the faculty, doctoral students, students of VNU-HCM in particular and other universities, institutes...\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal since 2020.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\" \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"2. Focus and Scope\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Publishing articles with contents on healthcare, research projects in the field of health, advanced directions in health education and management. Therefore, STDJ-HS will accept articles from doctors, administrators, teachers, researchers, graduate students and fellows. The authors will be responsible for the accuracy of the data, opinions, opinions and material cited in the article.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Facilitating the exchange of scientific and technological information and act as a bridge between theory and practice in the community of educators, scientists, managers, policy makers and enterprises in and out of the country.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}",{"EN":585,"VI":586},"VNUHCM JOURNAL OF HEALTH SCIENCES","Tạp chí Khoa học Sức khoẻ Đại học Quốc gia Thành phố Hồ Chí Minh",[101,102],[],[590],{"id":591,"createTime":592,"updateTime":593,"relativeEntities":594,"slug":595,"properties":596,"entityType":98,"verifyStatus":25,"verifyTime":606,"verifyNote":26,"syncStatus":28,"languages":607,"translateLanguages":26,"viewCount":608,"url":609,"parentIds":610,"statistic":611},"fc4c2560-868c-4677-acb1-8686bef88727","2023-06-26T04:48:23.774+00:00","2026-06-19T01:46:17.248+00:00",[],"%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-Th%C3%A0nh-ph%E1%BB%91-H%E1%BB%93-Ch%C3%AD-Minh",{"country":597,"title":598,"abbreviation":601,"address":603},{"VOID":15},{"EN":599,"VI":600},"Vietnam National University Ho Chi Minh City","Đại học Quốc gia Thành phố Hồ Chí Minh",{"VOID":602},"VNUHCM",{"VI":604,"EN":605},"khu phố 6, Phường Linh Trung, Thành phố Thủ Đức, Thành phố Hồ Chí Minh, Việt Nam","Quarter 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam","2023-08-16T14:13:07.134+00:00",[101,102],45,"https:\u002F\u002Fvnuhcm.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":612,"i10Index":285,"i10IndexLast5Year":51,"totalPublication":613,"totalPublicationByYear":614,"totalCitation":624,"totalCitationByYear":625,"totalCitationPerPublication":634,"totalCitationPerPublicationByYear":635,"hindexLast5Year":124,"hindex":124},{"2014":36,"2015":38,"2016":109,"2017":39,"2018":229,"2019":38,"2020":110,"2021":171,"2022":110,"2023":110,"2024":171,"2025":229},3708,{"2005":115,"2006":115,"2007":115,"2008":135,"2009":111,"2010":53,"2011":52,"2012":568,"2013":615,"2014":351,"2015":616,"2016":469,"2017":617,"2018":127,"2019":618,"2020":619,"2021":620,"2022":621,"2023":622,"2024":623,"2025":159,"2026":50},164,266,177,226,603,931,314,246,74,2399,{"2006":115,"2008":50,"2010":162,"2011":242,"2012":222,"2013":43,"2014":626,"2015":627,"2016":628,"2017":629,"2018":258,"2019":630,"2020":631,"2021":632,"2022":633,"2023":353,"2024":115},250,124,157,162,152,385,559,128,0.65,{"2006":115,"2008":636,"2010":637,"2011":638,"2012":639,"2013":522,"2014":640,"2015":641,"2016":642,"2017":643,"2018":644,"2019":642,"2020":645,"2021":292,"2022":646,"2023":522,"2024":38},1.33,0.45,2.22,0.39,1.35,0.47,0.67,0.92,0.73,0.64,0.41,[],"http:\u002F\u002Fstdjhs.scienceandtechnology.com.vn\u002Findex.php\u002Fstdjhs","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F19221551-7519-47ff-a892-331d1139c64b\u002F2e10768b7d1e380c36a25ed0c714dd7e.png",{"impactFactor":36,"impactFactorByYear":651,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":652,"totalPublicationByYear":653,"totalCitation":516,"totalCitationByYear":654,"totalCitationPerPublication":151,"totalCitationPerPublicationByYear":655,"hindexLast5Year":59,"hindex":59},{"2022":57,"2023":108,"2024":39},79,{"2020":116,"2021":240,"2022":239,"2023":52,"2024":162,"2025":162},{"2020":59,"2021":51,"2022":59},{"2020":443,"2021":387,"2022":54},{"code":657,"data":658,"meta":26},"SUCCESS",{"id":659,"createTime":660,"updateTime":661,"relativeEntities":662,"slug":663,"properties":664,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":669,"manageAffiliations":718,"indexDatabases":738,"url":26,"thumbnailPath":26,"statistic":782,"gsStatistic":26,"type":26,"analyzePriority":26},"1507fcc5-89ce-4fff-82f8-7f223f89e328","2024-04-12T01:34:45.698+00:00","2025-11-21T09:48:10.051+00:00",[],"Springer-Science-and-Business-Media-LLC",{"issn":665,"title":667},{"VOID":666},"1745-6150",{"EN":668},"Springer Science and Business Media LLC",[670,678,686,694,702,710],{"id":671,"createTime":672,"updateTime":673,"relativeEntities":674,"label":675,"description":677,"parentId":26,"standard":26,"scholarHubFieldId":26},"78a58205-ad3c-44c8-884e-f16b78feebfa","2023-05-29T10:24:10.811+00:00","2023-11-21T08:08:48.011+00:00",[],{"EN":676},"Modeling and Simulation",{},{"id":679,"createTime":680,"updateTime":681,"relativeEntities":682,"label":683,"description":685,"parentId":26,"standard":26,"scholarHubFieldId":26},"97cdf9a1-b6ca-4a4d-aa74-b136947bc142","2023-05-29T10:24:03.260+00:00","2023-11-21T06:49:46.360+00:00",[],{"EN":684},"Biochemistry, Genetics and Molecular Biology (miscellaneous)",{},{"id":687,"createTime":688,"updateTime":689,"relativeEntities":690,"label":691,"description":693,"parentId":26,"standard":26,"scholarHubFieldId":26},"b2f3603d-283c-49e1-a8f1-01f0de24243c","2023-05-29T10:24:14.495+00:00","2023-11-21T07:19:21.118+00:00",[],{"EN":692},"Immunology",{},{"id":695,"createTime":696,"updateTime":697,"relativeEntities":698,"label":699,"description":701,"parentId":26,"standard":26,"scholarHubFieldId":26},"ee33e266-088e-4829-aa2f-5ea59917dac0","2023-05-29T10:24:03.075+00:00","2023-11-21T08:08:48.024+00:00",[],{"EN":700},"Applied Mathematics",{},{"id":703,"createTime":704,"updateTime":705,"relativeEntities":706,"label":707,"description":709,"parentId":26,"standard":26,"scholarHubFieldId":26},"d685790f-7c6d-40e3-a211-948b6942dd3a","2023-05-29T10:24:01.451+00:00","2023-11-21T05:41:42.994+00:00",[],{"EN":708},"Agricultural and Biological Sciences (miscellaneous)",{},{"id":711,"createTime":712,"updateTime":713,"relativeEntities":714,"label":715,"description":717,"parentId":26,"standard":26,"scholarHubFieldId":26},"d01c5fde-3663-4bb5-9a9e-b5ebea4f38e2","2023-05-29T10:24:13.370+00:00","2023-11-21T07:49:36.907+00:00",[],{"EN":716},"Ecology, Evolution, Behavior and Systematics",{},[719,729],{"id":720,"createTime":721,"updateTime":722,"relativeEntities":723,"slug":724,"properties":725,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":116,"url":26,"parentIds":728,"statistic":26},"c5894808-4e99-4047-bbce-594f58821845","2023-05-29T10:24:08.212+00:00","2025-11-21T10:07:05.787+00:00",[],"BioMed-Central-Ltd-",{"title":726},{"EN":727},"BioMed Central Ltd.",[],{"id":730,"createTime":731,"updateTime":732,"relativeEntities":733,"slug":734,"properties":735,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":52,"url":26,"parentIds":737,"statistic":26},"67883518-0c98-470e-b6b0-160ab49bb03d","2023-05-29T12:06:59.969+00:00","2024-02-19T18:45:45.100+00:00",[],"BMC",{"title":736},{"EN":734},[],[739,763],{"id":740,"indexDatabase":741,"url":753,"indexYears":754,"academicFieldIds":755,"indexDatabaseRanking":762},"6f257e60-2679-4178-887c-7b4aa87f2557",{"id":742,"createTime":743,"updateTime":744,"relativeEntities":745,"label":746,"description":748,"key":750,"publicationTags":751,"standard":26},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":747,"VI":747},"Scopus - Elsevier",{"EN":747,"VI":749},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[752],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F5800173376","2006-2025",[756,757,758,759,760,761],"09f6b045-208a-4e88-8bae-2e53a1e1a893","2e85ca04-4b9c-4f3e-be83-f6e278d9077d","8e5f5f89-df86-44a7-bb58-d8bad424ac5f","95f8925b-50ef-457e-b85f-1ad0343f04b9","bf9d84ae-c584-4211-b4aa-5016d0d5d064","f58e9119-c14c-473f-8a7c-5a035e4ab69a","SCOPUS__Q1",{"id":764,"indexDatabase":765,"url":779,"indexYears":26,"academicFieldIds":780,"indexDatabaseRanking":26},"0453c543-7c18-4111-80b8-9ffc8be15ec8",{"id":766,"createTime":767,"updateTime":768,"relativeEntities":769,"label":770,"description":772,"key":775,"publicationTags":776,"standard":26},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":771,"VI":771},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":773,"EN":774},"Cơ sở dữ liệu SCIE","SCIE database","scie",[777,778],"SCIE","ISI","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002Fnull",[781],"2c74d252-030e-40f7-a6ff-6f4bef3a9461",{"impactFactor":36,"impactFactorByYear":783,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":792,"totalCitation":793,"totalCitationByYear":794,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":804,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},0.84,0.79,0.51,0.59,1.08,1.87,1.11,594,{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},3573,{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},470,485,399,394,307,175,299,62,6.02,{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},18.8,17.32,10.5,4.06,8.21,6.82,5.65,7.95,4.85,2.58,6.36,3.05,3.26,3.74,1.23,1.96,{"meta":822,"data":824},{"total":823},"597",[825,949,1238,1587,2035,2451,2807,3144,3243,3470],{"id":826,"createTime":827,"updateTime":828,"relativeEntities":829,"slug":830,"properties":831,"entityType":846,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":847,"translateLanguages":26,"viewCount":36,"primaryUrl":848,"fullTextUrl":26,"authors":849,"publicationType":912,"publisherRelationship":913,"citationCount":941,"citationInfo":942,"publishDate":944,"publishYear":945,"citationAnalyzeStatus":946,"lastCitationAnalyze":828,"indexDatabases":26,"openAccess":26,"references":947,"isForceReanalyzing":948},"a47e5889-b4c6-49b3-b9cb-251d134a8a2d","2024-04-11T22:18:47.961+00:00","2024-04-12T03:03:46.821+00:00",[],"Splign-algorithms-for-computing-spliced-alignments-with-identification-of-paralogs",{"mag":832,"keywords":834,"pmc":835,"openalex":837,"abstract":839,"title":840,"pm":842,"doi":844},{"VOID":833},"2040770546",{},{"VOID":836},"2440734",{"VOID":838},"W2040770546",{},{"EN":841},"Splign: algorithms for computing spliced alignments with identification of paralogs",{"VOID":843},"18495041",{"VOID":845},"10.1186\u002F1745-6150-3-20","PUBLICATION",[102],"http:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-3-20",[850,868,884,898],{"id":851,"sortIndex":36,"researcher":26,"roles":852,"affiliations":853,"properties":863},"da375799-d740-43eb-8a9d-4239e2256847",[],[854],{"id":26,"sortIndex":36,"affiliation":855,"properties":26},{"id":856,"createTime":857,"updateTime":857,"relativeEntities":858,"slug":859,"properties":860,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d6d13712-975a-475f-9246-04bc662061f9","2024-04-11T22:18:47.968+00:00",[],"National-Center-for-Biotechnology-Information-National-Library-of-Medicine-National-Institutes-of-Health-Bethesda-MD-20814-USA",{"title":861},{"EN":862},"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20814, USA",{"openalex":864,"title":866},{"VOID":865},"A5056045809",{"EN":867},"Yuri Kapustin",{"id":869,"sortIndex":59,"researcher":26,"roles":870,"affiliations":871,"properties":877},"e847d2d3-f732-46bd-9678-a96035d042d8",[],[872],{"id":26,"sortIndex":36,"affiliation":873,"properties":26},{"id":856,"createTime":857,"updateTime":857,"relativeEntities":874,"slug":859,"properties":875,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":876},{"EN":862},{"openalex":878,"orcid":880,"title":882},{"VOID":879},"A5056652131",{"VOID":881},"https:\u002F\u002Forcid.org\u002F0009-0002-3443-2023",{"EN":883},"David J. Lipman",{"id":885,"sortIndex":114,"researcher":26,"roles":886,"affiliations":887,"properties":893},"6e58eb09-3795-4dc2-8d7c-25fcc1e77dc6",[],[888],{"id":26,"sortIndex":36,"affiliation":889,"properties":26},{"id":856,"createTime":857,"updateTime":857,"relativeEntities":890,"slug":859,"properties":891,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":892},{"EN":862},{"openalex":894,"title":896},{"VOID":895},"A5073454926",{"EN":897},"Tatiana Tatusova",{"id":899,"sortIndex":115,"researcher":26,"roles":900,"affiliations":901,"properties":907},"da402be4-b005-4252-a906-a60ac77d0de7",[],[902],{"id":26,"sortIndex":36,"affiliation":903,"properties":26},{"id":856,"createTime":857,"updateTime":857,"relativeEntities":904,"slug":859,"properties":905,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":906},{"EN":862},{"openalex":908,"title":910},{"VOID":909},"A5037703132",{"EN":911},"Alexander Souvorov","ARTICLE",{"url":26,"publisher":914,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":915,"slug":663,"properties":916,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":919,"manageAffiliations":920,"indexDatabases":921,"url":26,"thumbnailPath":26,"statistic":936,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":917,"title":918},{"VOID":666},{"EN":668},[],[],[922,929],{"id":764,"indexDatabase":923,"url":779,"indexYears":26,"academicFieldIds":928,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":924,"label":925,"description":926,"key":775,"publicationTags":927,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":930,"url":753,"indexYears":754,"academicFieldIds":935,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":931,"label":932,"description":933,"key":750,"publicationTags":934,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":937,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":938,"totalCitation":793,"totalCitationByYear":939,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":940,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},310,{"total":941,"publishYear":26,"statisticByYear":943},{"2012":103,"2013":124,"2014":356,"2015":51,"2016":52,"2017":516,"2018":260,"2019":125,"2020":79,"2021":237,"2022":222,"2023":125,"2024":111},"2008-01-01",2008,"ERROR_IN_ANALYZE_CITATION",[],false,{"id":950,"createTime":951,"updateTime":951,"relativeEntities":952,"slug":953,"properties":954,"entityType":846,"verifyStatus":25,"verifyTime":951,"verifyNote":969,"syncStatus":28,"languages":970,"translateLanguages":26,"viewCount":36,"primaryUrl":971,"fullTextUrl":26,"authors":972,"publicationType":912,"publisherRelationship":1198,"citationCount":618,"citationInfo":1233,"publishDate":1235,"publishYear":1236,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1237,"isForceReanalyzing":948},"f365b14c-8296-4c5c-962f-1ad9f487f704","2024-10-12T18:53:13.608+00:00",[],"Prokaryotic-evolution-and-the-tree-of-life-are-two-different-things",{"mag":955,"keywords":957,"pmc":958,"openalex":960,"abstract":962,"title":963,"pm":965,"doi":967},{"VOID":956},"2119161962",{},{"VOID":959},"2761302",{"VOID":961},"W2119161962",{},{"EN":964},"Prokaryotic evolution and the tree of life are two different things",{"VOID":966},"19788731",{"VOID":968},"10.1186\u002F1745-6150-4-34","Auto Verify",[102],"http:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-4-34",[973,994,1013,1035,1057,1079,1101,1123,1140,1162,1181],{"id":974,"sortIndex":36,"researcher":26,"roles":975,"affiliations":976,"properties":987},"ecd8af48-000a-4be8-b392-d7f5300ade41",[],[977],{"id":978,"sortIndex":36,"affiliation":979,"properties":26},"600f10df-3c3d-4eae-903c-7a7e713bd35c",{"id":980,"createTime":981,"updateTime":981,"relativeEntities":982,"slug":983,"properties":984,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a692625c-c282-48e3-af92-2bbae3fd3288","2024-10-12T18:53:13.626+00:00",[],"UPMC-UMR-CNRS-7138-Paris-France",{"title":985},{"EN":986},"UPMC, UMR CNRS 7138, Paris, France",{"openalex":988,"orcid":990,"title":992},{"VOID":989},"A5061336204",{"VOID":991},"https:\u002F\u002Forcid.org\u002F0000-0003-1966-1215",{"EN":993},"Éric Bapteste",{"id":995,"sortIndex":162,"researcher":26,"roles":996,"affiliations":997,"properties":1008},"abf41335-214a-4926-a83a-6a6bdf75d59c",[],[998],{"id":999,"sortIndex":36,"affiliation":1000,"properties":26},"20f49202-169b-4c49-a95c-08651594f2b8",{"id":1001,"createTime":1002,"updateTime":1002,"relativeEntities":1003,"slug":1004,"properties":1005,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"80ffd1e6-817a-40e2-a2d6-c01279ffeaba","2024-10-12T18:53:13.661+00:00",[],"Department-of-Philosophy-NYU-USA",{"title":1006},{"EN":1007},"Department of Philosophy, NYU, USA",{"openalex":1009,"title":1011},{"VOID":1010},"A5021540127",{"EN":1012},"L. R. Franklin-Hall",{"id":1014,"sortIndex":115,"researcher":26,"roles":1015,"affiliations":1016,"properties":1028},"6d347258-768b-4e8b-850a-e0a96e1acfcf",[],[1017],{"id":1018,"sortIndex":36,"affiliation":1019,"properties":26},"b859ad74-64e1-48d6-bcd1-df5d81ec9a79",{"id":1020,"createTime":1021,"updateTime":1022,"relativeEntities":1023,"slug":1024,"properties":1025,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"3a7b173e-d6b1-4792-a12e-aa50778f1f8a","2024-01-01T10:26:20.649+00:00","2024-12-14T13:36:24.248+00:00",[],"ESRC-Centre-for-Genomics-in-Society-Egenis-University-of-Exeter-Exeter-UK",{"title":1026},{"VI":1027},"ESRC Centre for Genomics in Society (Egenis), University of Exeter, Exeter, UK",{"openalex":1029,"orcid":1031,"title":1033},{"VOID":1030},"A5052479288",{"VOID":1032},"https:\u002F\u002Forcid.org\u002F0000-0003-0367-7079",{"EN":1034},"Maureen A. O’Malley",{"id":1036,"sortIndex":52,"researcher":26,"roles":1037,"affiliations":1038,"properties":1050},"3b342c0d-86e5-42dd-b64a-7184347b388d",[],[1039],{"id":1040,"sortIndex":36,"affiliation":1041,"properties":26},"f5502550-5f6f-4841-af41-e2ca5ddaf237",{"id":1042,"createTime":1043,"updateTime":1044,"relativeEntities":1045,"slug":1046,"properties":1047,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"f5e588fd-1339-4a29-88d4-621db08101cb","2024-01-25T20:55:11.267+00:00","2024-10-12T18:53:13.696+00:00",[],"Department-of-Civil-and-Environmental-Engineering-MIT-Cambridge-USA",{"title":1048},{"VI":1049},"Department of Civil and Environmental Engineering, MIT, Cambridge, USA",{"openalex":1051,"orcid":1053,"title":1055},{"VOID":1052},"A5065634962",{"VOID":1054},"https:\u002F\u002Forcid.org\u002F0000-0002-0036-6083",{"EN":1056},"Yan Boucher",{"id":1058,"sortIndex":135,"researcher":26,"roles":1059,"affiliations":1060,"properties":1072},"5175f530-04a3-4eac-a10c-23989b6b3db3",[],[1061],{"id":1062,"sortIndex":36,"affiliation":1063,"properties":26},"3e754ae3-6181-4312-8969-2a27c126f224",{"id":1064,"createTime":1065,"updateTime":1066,"relativeEntities":1067,"slug":1068,"properties":1069,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a411987a-2a55-49d4-8822-e3c75bd1b504","2023-12-06T08:15:44.183+00:00","2024-10-12T18:53:13.671+00:00",[],"D%C3%A9partement-de-Sciences-biologiques-Universit%C3%A9-de-Montr%C3%A9al-Montr%C3%A9al-Canada",{"title":1070},{"VI":1071},"Département de Sciences biologiques, Université de Montréal, Montréal, Canada",{"openalex":1073,"orcid":1075,"title":1077},{"VOID":1074},"A5086298808",{"VOID":1076},"https:\u002F\u002Forcid.org\u002F0000-0002-0327-9073",{"EN":1078},"François‐Joseph Lapointe",{"id":1080,"sortIndex":114,"researcher":26,"roles":1081,"affiliations":1082,"properties":1094},"ea89d356-8963-4675-ac3b-0322a574d7f0",[],[1083],{"id":1084,"sortIndex":36,"affiliation":1085,"properties":26},"33e329b7-e912-4fad-990f-ec59f94a6758",{"id":1086,"createTime":1087,"updateTime":1088,"relativeEntities":1089,"slug":1090,"properties":1091,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"08a461d9-d973-4551-8b6a-fcfeb7b45884","2024-04-20T12:02:02.056+00:00","2025-06-11T21:37:33.392+00:00",[],"Faculty-of-Computer-Science-Dalhousie-University-Halifax-Canada",{"title":1092},{"EN":1093},"Faculty of Computer Science, Dalhousie University, Halifax, Canada",{"openalex":1095,"orcid":1097,"title":1099},{"VOID":1096},"A5063083987",{"VOID":1098},"https:\u002F\u002Forcid.org\u002F0000-0002-5065-4980",{"EN":1100},"Robert G. Beiko",{"id":1102,"sortIndex":116,"researcher":26,"roles":1103,"affiliations":1104,"properties":1116},"61ec076b-aa9c-4259-bb4e-38c3efcccbe0",[],[1105],{"id":1106,"sortIndex":36,"affiliation":1107,"properties":26},"787bf954-2eed-4766-81f8-9c40624de1bc",{"id":1108,"createTime":1109,"updateTime":1110,"relativeEntities":1111,"slug":1112,"properties":1113,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"497f4c21-8f48-48e4-9056-1586d668d936","2024-04-17T21:19:01.349+00:00","2024-10-12T18:53:13.686+00:00",[],"Institute-of-Botany-University-of-D%C3%BCsseldorf-D%C3%BCsseldorf-Germany",{"title":1114},{"EN":1115},"Institute of Botany, University of Düsseldorf, Düsseldorf, Germany",{"openalex":1117,"orcid":1119,"title":1121},{"VOID":1118},"A5016571082",{"VOID":1120},"https:\u002F\u002Forcid.org\u002F0000-0003-1478-6449",{"EN":1122},"William Martin",{"id":1124,"sortIndex":158,"researcher":26,"roles":1125,"affiliations":1126,"properties":1133},"3eed213d-f8b3-4692-8b9b-4f56cf884720",[],[1127],{"id":1128,"sortIndex":36,"affiliation":1129,"properties":26},"4593fb56-76f3-4f3b-bbc5-d7493d1c37ed",{"id":1020,"createTime":1021,"updateTime":1022,"relativeEntities":1130,"slug":1024,"properties":1131,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1132},{"VI":1027},{"openalex":1134,"orcid":1136,"title":1138},{"VOID":1135},"A5022365950",{"VOID":1137},"https:\u002F\u002Forcid.org\u002F0000-0002-7451-2127",{"EN":1139},"John Dupré",{"id":1141,"sortIndex":111,"researcher":26,"roles":1142,"affiliations":1143,"properties":1155},"c2708230-0262-4b4b-8378-d9f8b4ab2942",[],[1144],{"id":1145,"sortIndex":36,"affiliation":1146,"properties":26},"aa2b9f84-8eaf-4893-ab26-1b04f8c11f13",{"id":1147,"createTime":1148,"updateTime":1149,"relativeEntities":1150,"slug":1151,"properties":1152,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b07845ca-94f9-4827-986b-df80a0a5a4d9","2023-11-25T13:09:22.024+00:00","2024-10-12T18:53:13.654+00:00",[],"Department-of-Molecular-and-Cell-Biology-University-of-Connecticut-USA",{"title":1153},{"VI":1154},"Department of Molecular and Cell Biology, University of Connecticut, USA",{"openalex":1156,"orcid":1158,"title":1160},{"VOID":1157},"A5045259703",{"VOID":1159},"https:\u002F\u002Forcid.org\u002F0000-0001-6459-6518",{"EN":1161},"J. Peter Gogarten",{"id":1163,"sortIndex":59,"researcher":26,"roles":1164,"affiliations":1165,"properties":1176},"15224946-5f79-4da3-9e2a-79817f85ce94",[],[1166],{"id":1167,"sortIndex":36,"affiliation":1168,"properties":26},"b0601302-d73f-434c-8ab9-5f632a57c2a9",{"id":1169,"createTime":1170,"updateTime":1170,"relativeEntities":1171,"slug":1172,"properties":1173,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b5ac76bd-f027-48d0-b395-7890799736e0","2024-10-12T18:53:13.644+00:00",[],"Department-of-Philosophy-University-of-Calgary-Calgary-Canada-TAB-",{"title":1174},{"EN":1175},"Department of Philosophy, University of Calgary, Calgary, Canada#TAB#",{"openalex":1177,"title":1179},{"VOID":1178},"A5053738750",{"EN":1180},"Marc Ereshefsky",{"id":1182,"sortIndex":50,"researcher":26,"roles":1183,"affiliations":1184,"properties":1191},"35284d4c-a916-4599-a4d3-f6fd0b7fc6d2",[],[1185],{"id":1186,"sortIndex":36,"affiliation":1187,"properties":26},"f309739e-da65-4079-a15d-3b2e2d77c619",{"id":1108,"createTime":1109,"updateTime":1110,"relativeEntities":1188,"slug":1112,"properties":1189,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1190},{"EN":1115},{"openalex":1192,"orcid":1194,"title":1196},{"VOID":1193},"A5004587704",{"VOID":1195},"https:\u002F\u002Forcid.org\u002F0000-0002-9042-192X",{"EN":1197},"Tal Dagan",{"url":26,"publisher":1199,"properties":1226},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1200,"slug":663,"properties":1201,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1204,"manageAffiliations":1205,"indexDatabases":1206,"url":26,"thumbnailPath":26,"statistic":1221,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1202,"title":1203},{"VOID":666},{"EN":668},[],[],[1207,1214],{"id":764,"indexDatabase":1208,"url":779,"indexYears":26,"academicFieldIds":1213,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":1209,"label":1210,"description":1211,"key":775,"publicationTags":1212,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":1215,"url":753,"indexYears":754,"academicFieldIds":1220,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":1216,"label":1217,"description":1218,"key":750,"publicationTags":1219,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":1222,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":1223,"totalCitation":793,"totalCitationByYear":1224,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":1225,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"volume":1227,"pages":1229,"issue":1231},{"VOID":1228},"4",{"VOID":1230},"34",{"VOID":1232},"1",{"total":618,"publishYear":26,"statisticByYear":1234},{"2012":244,"2013":516,"2014":173,"2015":51,"2016":53,"2017":103,"2018":116,"2019":336,"2020":116,"2021":116,"2022":135,"2023":59,"2024":162},"2009-01-01",2009,[],{"id":1239,"createTime":1240,"updateTime":1241,"relativeEntities":1242,"slug":1243,"properties":1244,"entityType":846,"verifyStatus":25,"verifyTime":1241,"verifyNote":969,"syncStatus":28,"languages":1263,"translateLanguages":1264,"viewCount":36,"primaryUrl":1265,"fullTextUrl":26,"authors":1266,"publicationType":912,"publisherRelationship":1362,"citationCount":1393,"citationInfo":1394,"publishDate":1396,"publishYear":1397,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1398,"isForceReanalyzing":948},"17bf6e1c-8627-47dc-b552-9b37dc12b4ce","2024-04-18T10:43:23.643+00:00","2025-02-26T22:47:26.187+00:00",[],"Long-intervals-of-stasis-punctuated-by-bursts-of-positive-selection-in-the-seasonal-evolution-of-influenza-A-virus",{"mag":1245,"keywords":1247,"pmc":1249,"openalex":1251,"abstract":1253,"title":1256,"pm":1259,"doi":1261},{"VOID":1246},"2109874333",{"VI":1248},"",{"VOID":1250},"1647279",{"VOID":1252},"W2109874333",{"VI":1254,"EN":1255},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Đặt vấn đề\u003C\u002Fjats:title>\n            \u003Cjats:p>Sự tiến hóa giữa các đợt đại dịch của protein hemagglutinin (HA) virus cúm A thường được coi là một hình mẫu cho sự thay đổi tiến hóa nhanh chóng dưới áp lực chọn lọc tích cực, trong đó các thay thế acid amin được cố định nhờ tác động của chúng lên tính kháng nguyên, giúp virus né tránh sự giám sát của hệ miễn dịch.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Chúng tôi đã thực hiện phân tích phát sinh chủng loại của các mẫu HA lớn và tương đối không thiên lệch được thu thập từ các mẫu virus cúm A H3N2 và H1N1 trong giai đoạn 1995–2005. Không ngờ rằng sự tiến hóa của HA H3N2 bao gồm những khoảng thời gian dài của sự tiến hóa chuỗi trung tính mà không có sự thay đổi kháng nguyên rõ ràng (\"giai đoạn stasis\") được đặc trưng bởi sự vượt trội của các thay thế đồng nghĩa so với các thay thế không đồng nghĩa tại mỗi vị trí, sự thiếu mối liên hệ giữa các thay thế acid amin với các vùng kháng nguyên, và sự tuyệt chủng chậm của các dòng virus đồng thời. Những khoảng thời gian stasis dài này được phân đoạn bởi những khoảng thời gian ngắn của sự tiến hóa nhanh chóng dưới áp lực chọn lọc tích cực, trong đó các dòng thống trị mới nhanh chóng thay thế những dòng đã tồn tại trước đó. Tính vượt trội của chọn lọc tích cực trong các khoảng thời gian tiến hóa nhanh được hỗ trợ bởi sự vượt trội rõ rệt của các thay thế acid amin trong các vùng kháng nguyên của HA so với các thay thế trong phần còn lại của phân tử HA. Ngược lại, các khoảng thời gian stasis cho thấy sự phân bố thay thế đồng nhất hơn nhiều trên toàn bộ phân tử HA, với sự khác biệt có ý nghĩa thống kê về tỷ lệ thay thế đồng nghĩa so với không đồng nghĩa trong các vùng kháng nguyên giữa hai chế độ tiến hóa. Một số thay thế acid amin song song - cùng một loại thay thế acid amin xảy ra độc lập ở các dòng khác nhau - cũng đã được phát hiện trong HA H3N2. Những đột biến song song này chủ yếu liên quan đến các khoảng thời gian thay đổi khả năng sống sót nhanh chóng, cho thấy có những giới hạn lớn đối với các con đường tiến hóa trong suốt sự thay đổi kháng nguyên. Phát hiện rằng stasis là hình thức chiếm ưu thế trong sự tiến hóa của H3N2 cho thấy rằng những thay đổi kháng nguyên dẫn đến sự tăng cường khả năng sống sót thường xuất phát từ các tương tác ép tích cực giữa một số thay thế acid amin trong HA và, có thể, các protein virus khác. Các chủng trở nên thống trị nhờ vào việc tăng cường khả năng sống sót xuất hiện từ các chủng có tần suất thấp, nhờ thay thế acid amin cuối cùng hoàn thiện tập hợp thay thế cần thiết để tạo ra một thay đổi kháng nguyên có ý nghĩa; không có tập hợp thay thế nào dẫn đến một thay đổi kháng nguyên có ý nghĩa sinh học và sự gia tăng khả năng sống sót tương ứng. Ngược lại với H3N2, không phát hiện thấy các khoảng thời gian rõ ràng của sự tiến hóa dưới áp lực chọn lọc tích cực đối với HA H1N1 trong cùng khoảng thời gian. Do đó, sự nổi lên của H1N1 trong một số mùa là, rất có thể, do sự giảm thiểu khả năng sống sót tương đối của các dòng H3N2 trước đó khi phần trăm chủ thể dễ bị nhiễm giảm trong các khoảng thời gian stasis.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>The interpandemic evolution of the influenza A virus hemagglutinin (HA) protein is commonly considered a paragon of rapid evolutionary change under positive selection in which amino acid replacements are fixed by virtue of their effect on antigenicity, enabling the virus to evade immune surveillance.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>We performed phylogenetic analyses of the recently obtained large and relatively unbiased samples of the HA sequences from 1995–2005 isolates of the H3N2 and H1N1 subtypes of influenza A virus. Unexpectedly, it was found that the evolution of H3N2 HA includes long intervals of generally neutral sequence evolution without apparent substantial antigenic change (\"stasis\" periods) that are characterized by an excess of synonymous over nonsynonymous substitutions per site, lack of association of amino acid replacements with epitope regions, and slow extinction of coexisting virus lineages. These long periods of stasis are punctuated by shorter intervals of rapid evolution under positive selection during which new dominant lineages quickly displace previously coexisting ones. The preponderance of positive selection during intervals of rapid evolution is supported by the dramatic excess of amino acid replacements in the epitope regions of HA compared to replacements in the rest of the HA molecule. In contrast, the stasis intervals showed a much more uniform distribution of replacements over the HA molecule, with a statistically significant difference in the rate of synonymous over nonsynonymous substitution in the epitope regions between the two modes of evolution. A number of parallel amino acid replacements – the same amino acid substitution occurring independently in different lineages – were also detected in H3N2 HA. These parallel mutations were, largely, associated with periods of rapid fitness change, indicating that there are major limitations on evolutionary pathways during antigenic change. The finding that stasis is the prevailing modality of H3N2 evolution suggests that antigenic changes that lead to an increase in fitness typically result from epistatic interactions between several amino acid substitutions in the HA and, perhaps, other viral proteins. The strains that become dominant due to increased fitness emerge from low frequency strains thanks to the last amino acid replacement that completes the set of replacements required to produce a significant antigenic change; no subset of substitutions results in a biologically significant antigenic change and corresponding fitness increase. In contrast to H3N2, no clear intervals of evolution under positive selection were detected for the H1N1 HA during the same time span. Thus, the ascendancy of H1N1 in some seasons is, most likely, caused by the drop in the relative fitness of the previously prevailing H3N2 lineages as the fraction of susceptible hosts decreases during the stasis intervals.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>We show that the common view of the evolution of influenza virus as a rapid, positive selection-driven process is, at best, incomplete. Rather, the interpandemic evolution of influenza appears to consist of extended intervals of stasis, which are characterized by neutral sequence evolution, punctuated by shorter intervals of rapid fitness increase when evolutionary change is driven by positive selection. These observations have implications for influenza surveillance and vaccine formulation; in particular, the possibility exists that parallel amino acid replacements could serve as a predictor of new dominant strains.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Reviewers\u003C\u002Fjats:title>\n            \u003Cjats:p>Ron Fouchier (nominated by Andrey Rzhetsky), David Krakauer, Christopher Lee\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":1257,"EN":1258},"Những khoảng thời gian stasis dài được ngắt quãng bởi những đợt chọn lọc tích cực trong sự tiến hóa theo mùa của virus cúm A","Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virus",{"VOID":1260},"17067369",{"VOID":1262},"10.1186\u002F1745-6150-1-34",[102],[101],"https:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-1-34",[1267,1289,1312,1326,1345],{"id":1268,"sortIndex":36,"researcher":26,"roles":1269,"affiliations":1270,"properties":1282},"d440d145-96a3-4f36-a13e-85ff1150a9d8",[],[1271],{"id":1272,"sortIndex":36,"affiliation":1273,"properties":26},"4ff2d494-c029-45c5-826f-d897de0b05c0",{"id":1274,"createTime":1275,"updateTime":1276,"relativeEntities":1277,"slug":1278,"properties":1279,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b18fcbc1-8c71-4166-9204-dfa6c32022d3","2024-02-14T04:33:19.172+00:00","2024-12-04T18:23:11.607+00:00",[],"National-Center-for-Biotechnology-Information-National-Library-of-Medicine-National-Institutes-of-Health-Bethesda-MD-USA",{"title":1280},{"VI":1281},"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA",{"openalex":1283,"orcid":1285,"title":1287},{"VOID":1284},"A5012792532",{"VOID":1286},"https:\u002F\u002Forcid.org\u002F0000-0002-0247-8708",{"EN":1288},"Yuri I. Wolf",{"id":1290,"sortIndex":115,"researcher":26,"roles":1291,"affiliations":1292,"properties":1307},"b41093fc-fa24-4d67-8f51-6e4b54361682",[],[1293],{"id":1294,"sortIndex":36,"affiliation":1295,"properties":1304},"0a80aced-3363-414d-8d1d-893ebe6dfb2b",{"id":1296,"createTime":1297,"updateTime":1298,"relativeEntities":1299,"slug":1300,"properties":1301,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"03a32859-d075-4ced-99db-21f997ed5c4a","2024-01-16T17:26:18.454+00:00","2025-06-11T16:57:50.906+00:00",[],"Fogarty-International-Center-National-Institutes-of-Health-Bethesda-MD-United-States",{"title":1302},{"VI":1303},"Fogarty International Center, National Institutes of Health, Bethesda, MD, United States",{"title":1305},{"EN":1306},"Fogarty International Center, National Institutes of Health, Bethesda, MD, USA",{"openalex":1308,"title":1310},{"VOID":1309},"A5073384203",{"EN":1311},"Cécile Viboud",{"id":1313,"sortIndex":111,"researcher":26,"roles":1314,"affiliations":1315,"properties":1322},"6f2660ec-d0bd-44f9-a5bc-60e179971597",[],[1316],{"id":1317,"sortIndex":36,"affiliation":1318,"properties":26},"63961e54-c42d-411c-ace4-9c56252a81f5",{"id":1274,"createTime":1275,"updateTime":1276,"relativeEntities":1319,"slug":1278,"properties":1320,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1321},{"VI":1281},{"openalex":1323,"orcid":1324,"title":1325},{"VOID":879},{"VOID":881},{"EN":883},{"id":1327,"sortIndex":114,"researcher":26,"roles":1328,"affiliations":1329,"properties":1338},"0b903ef0-a0ce-4e79-943a-868f1dfb4c33",[],[1330],{"id":1331,"sortIndex":36,"affiliation":1332,"properties":1336},"1e2c3145-5ee2-40e5-8912-0a19521f42d6",{"id":1296,"createTime":1297,"updateTime":1298,"relativeEntities":1333,"slug":1300,"properties":1334,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1335},{"VI":1303},{"title":1337},{"EN":1306},{"openalex":1339,"orcid":1341,"title":1343},{"VOID":1340},"A5085736091",{"VOID":1342},"https:\u002F\u002Forcid.org\u002F0000-0001-9596-3552",{"EN":1344},"Edward C. Holmes",{"id":1346,"sortIndex":59,"researcher":26,"roles":1347,"affiliations":1348,"properties":1355},"ded08006-d200-452d-b07b-73cdbff936fd",[],[1349],{"id":1350,"sortIndex":36,"affiliation":1351,"properties":26},"035b9bc8-41f0-41a2-b864-9ba99c473322",{"id":1274,"createTime":1275,"updateTime":1276,"relativeEntities":1352,"slug":1278,"properties":1353,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1354},{"VI":1281},{"openalex":1356,"orcid":1358,"title":1360},{"VOID":1357},"A5035240489",{"VOID":1359},"https:\u002F\u002Forcid.org\u002F0000-0003-3943-8299",{"EN":1361},"Eugene V. Koonin",{"url":26,"publisher":1363,"properties":1390},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1364,"slug":663,"properties":1365,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1368,"manageAffiliations":1369,"indexDatabases":1370,"url":26,"thumbnailPath":26,"statistic":1385,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1366,"title":1367},{"VOID":666},{"EN":668},[],[],[1371,1378],{"id":764,"indexDatabase":1372,"url":779,"indexYears":26,"academicFieldIds":1377,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":1373,"label":1374,"description":1375,"key":775,"publicationTags":1376,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":1379,"url":753,"indexYears":754,"academicFieldIds":1384,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":1380,"label":1381,"description":1382,"key":750,"publicationTags":1383,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":1386,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":1387,"totalCitation":793,"totalCitationByYear":1388,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":1389,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"volume":1391,"issue":1392},{"VOID":1232},{"VOID":1232},184,{"total":1393,"publishYear":26,"statisticByYear":1395},{"2012":51,"2013":116,"2014":135,"2015":50,"2016":116,"2017":50,"2018":50,"2019":356,"2020":52,"2021":356,"2022":135,"2023":158},"2006-12-01",2006,[1399,1403,1407,1411,1415,1418,1422,1426,1430,1434,1437,1441,1445,1449,1453,1457,1460,1464,1468,1472,1476,1480,1484,1488,1492,1496,1500,1504,1508,1512,1516,1520,1523,1527,1531,1534,1537,1541,1545,1548,1552,1555,1559,1562,1565,1568,1571,1575,1579,1583],{"id":26,"text":1400,"url":26,"identifiers":1401},"Stohr K: Influenza--WHO cares. Lancet Infect Dis 2002,2(9):517. 10.1016\u002FS1473-3099(02)00366-3",{"doi":1402},"10.1016\u002FS1473-3099(02)00366-3",{"id":26,"text":1404,"url":26,"identifiers":1405},"Hilleman MR: Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control. Vaccine 2002,20(25-26):3068-3087. 10.1016\u002FS0264-410X(02)00254-2",{"doi":1406},"10.1016\u002FS0264-410X(02)00254-2",{"id":26,"text":1408,"url":26,"identifiers":1409},"De Jong JC, Rimmelzwaan GF, Fouchier RA, Osterhaus AD: Influenza virus: a master of metamorphosis. J Infect 2000,40(3):218-228. 10.1053\u002Fjinf.2000.0652",{"doi":1410},"10.1053\u002Fjinf.2000.0652",{"id":26,"text":1412,"url":26,"identifiers":1413},"Ferguson NM, Galvani AP, Bush RM: Ecological and immunological determinants of influenza evolution. Nature 2003,422(6930):428-433. 10.1038\u002Fnature01509",{"doi":1414},"10.1038\u002Fnature01509",{"id":26,"text":1416,"url":26,"identifiers":1417},"CDC: Flu Activity, Reports & Surveillance methods in the United States.[http:\u002F\u002Fwww.cdc.gov\u002Fflu\u002Fweekly\u002Ffluactivity.htm]",{},{"id":26,"text":1419,"url":26,"identifiers":1420},"Xu X, Cox NJ, Bender CA, Regnery HL, Shaw MW: Genetic variation in neuraminidase genes of influenza A (H3N2) viruses. Virology 1996,224(1):175-183. 10.1006\u002Fviro.1996.0519",{"doi":1421},"10.1006\u002Fviro.1996.0519",{"id":26,"text":1423,"url":26,"identifiers":1424},"Lindstrom SE, Hiromoto Y, Nerome R, Omoe K, Sugita S, Yamazaki Y, Takahashi T, Nerome K: Phylogenetic analysis of the entire genome of influenza A (H3N2) viruses from Japan: evidence for genetic reassortment of the six internal genes. J Virol 1998,72(10):8021-8031.",{"doi":1425},"10.1128\u002FJVI.72.10.8021-8031.1998",{"id":26,"text":1427,"url":26,"identifiers":1428},"Barr IG, Komadina N, Hurt AC, Iannello P, Tomasov C, Shaw R, Durrant C, Sjogren H, Hampson AW: An influenza A(H3) reassortant was epidemic in Australia and New Zealand in 2003. J Med Virol 2005,76(3):391-397. 10.1002\u002Fjmv.20374",{"doi":1429},"10.1002\u002Fjmv.20374",{"id":26,"text":1431,"url":26,"identifiers":1432},"Holmes EC, Ghedin E, Miller N, Taylor J, Bao Y, St George K, Grenfell BT, Salzberg SL, Fraser CM, Lipman DJ, Taubenberger JK: Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses. PLoS Biol 2005,3(9):e300. 10.1371\u002Fjournal.pbio.0030300",{"doi":1433},"10.1371\u002Fjournal.pbio.0030300",{"id":26,"text":1435,"url":26,"identifiers":1436},"Ratner VA, Kolchanov NA, Omel'ianchuk LV: [Phylogenetic analysis of genes of the influenza virus. Relationship between adaptability and neutrality]. Genetika 1989,25(8):1499-1507.",{},{"id":26,"text":1438,"url":26,"identifiers":1439},"Fitch WM, Leiter JM, Li XQ, Palese P: Positive Darwinian evolution in human influenza A viruses. Proc Natl Acad Sci U S A 1991,88(10):4270-4274. 10.1073\u002Fpnas.88.10.4270",{"doi":1440},"10.1073\u002Fpnas.88.10.4270",{"id":26,"text":1442,"url":26,"identifiers":1443},"Ina Y, Gojobori T: Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses. Proc Natl Acad Sci U S A 1994,91(18):8388-8392. 10.1073\u002Fpnas.91.18.8388",{"doi":1444},"10.1073\u002Fpnas.91.18.8388",{"id":26,"text":1446,"url":26,"identifiers":1447},"Bush RM, Fitch WM, Bender CA, Cox NJ: Positive selection on the H3 hemagglutinin gene of human influenza virus A. Mol Biol Evol 1999,16(11):1457-1465.",{"doi":1448},"10.1093\u002Foxfordjournals.molbev.a026057",{"id":26,"text":1450,"url":26,"identifiers":1451},"Plotkin JB, Dushoff J, Levin SA: Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus. Proc Natl Acad Sci U S A 2002,99(9):6263-6268. 10.1073\u002Fpnas.082110799",{"doi":1452},"10.1073\u002Fpnas.082110799",{"id":26,"text":1454,"url":26,"identifiers":1455},"Layne SP: Human influenza surveillance: the demand to expand. Emerg Infect Dis 2006,12(4):562-568.",{"doi":1456},"10.3201\u002Feid1204.051198",{"id":26,"text":1458,"url":26,"identifiers":1459},"NCBI: NCBI Influenza Virus Resource.[http:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fgenomes\u002FFLU\u002FFLU.html]",{},{"id":26,"text":1461,"url":26,"identifiers":1462},"Ghedin E, Sengamalay NA, Shumway M, Zaborsky J, Feldblyum T, Subbu V, Spiro DJ, Sitz J, Koo H, Bolotov P, Dernovoy D, Tatusova T, Bao Y, St George K, Taylor J, Lipman DJ, Fraser CM, Taubenberger JK, Salzberg SL: Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature 2005,437(7062):1162-1166. 10.1038\u002Fnature04239",{"doi":1463},"10.1038\u002Fnature04239",{"id":26,"text":1465,"url":26,"identifiers":1466},"Smith DJ, Lapedes AS, de Jong JC, Bestebroer TM, Rimmelzwaan GF, Osterhaus AD, Fouchier RA: Mapping the antigenic and genetic evolution of influenza virus. Science 2004,305(5682):371-376. 10.1126\u002Fscience.1097211",{"doi":1467},"10.1126\u002Fscience.1097211",{"id":26,"text":1469,"url":26,"identifiers":1470},"Hurst LD: The Ka\u002FKs ratio: diagnosing the form of sequence evolution. Trends Genet 2002,18(9):486. 10.1016\u002FS0168-9525(02)02722-1",{"doi":1471},"10.1016\u002FS0168-9525(02)02722-1",{"id":26,"text":1473,"url":26,"identifiers":1474},"Weinreich DM, Delaney NF, Depristo MA, Hartl DL: Darwinian evolution can follow only very few mutational paths to fitter proteins. Science 2006,312(5770):111-114. 10.1126\u002Fscience.1123539",{"doi":1475},"10.1126\u002Fscience.1123539",{"id":26,"text":1477,"url":26,"identifiers":1478},"Viboud C, Bjornstad ON, Smith DL, Simonsen L, Miller MA, Grenfell BT: Synchrony, waves, and spatial hierarchies in the spread of influenza. Science 2006,312(5772):447-451. 10.1126\u002Fscience.1125237",{"doi":1479},"10.1126\u002Fscience.1125237",{"id":26,"text":1481,"url":26,"identifiers":1482},"Sonoguchi T, Naito H, Hara M, Takeuchi Y, Fukumi H: Cross-subtype protection in humans during sequential, overlapping, and\u002For concurrent epidemics caused by H3N2 and H1N1 influenza viruses. J Infect Dis 1985,151(1):81-88.",{"doi":1483},"10.1093\u002Finfdis\u002F151.1.81",{"id":26,"text":1485,"url":26,"identifiers":1486},"Epstein SL: Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature. J Infect Dis 2006,193(1):49-53. 10.1086\u002F498980",{"doi":1487},"10.1086\u002F498980",{"id":26,"text":1489,"url":26,"identifiers":1490},"Nakajima K, Nobusawa E, Nagy A, Nakajima S: Accumulation of amino acid substitutions promotes irreversible structural changes in the hemagglutinin of human influenza AH3 virus during evolution. J Virol 2005,79(10):6472-6477. 10.1128\u002FJVI.79.10.6472-6477.2005",{"doi":1491},"10.1128\u002FJVI.79.10.6472-6477.2005",{"id":26,"text":1493,"url":26,"identifiers":1494},"Bonhoeffer S, Chappey C, Parkin NT, Whitcomb JM, Petropoulos CJ: Evidence for positive epistasis in HIV-1. Science 2004,306(5701):1547-1550. 10.1126\u002Fscience.1101786",{"doi":1495},"10.1126\u002Fscience.1101786",{"id":26,"text":1497,"url":26,"identifiers":1498},"Chen L, Lee C: Distinguishing HIV-1 drug resistance, accessory, and viral fitness mutations using conditional selection pressure analysis of treated versus untreated patient samples. Biol Direct 2006, 1: 14. 10.1186\u002F1745-6150-1-14",{"doi":1499},"10.1186\u002F1745-6150-1-14",{"id":26,"text":1501,"url":26,"identifiers":1502},"Sanjuan R, Moya A, Elena SF: The contribution of epistasis to the architecture of fitness in an RNA virus. Proc Natl Acad Sci U S A 2004,101(43):15376-15379. 10.1073\u002Fpnas.0404125101",{"doi":1503},"10.1073\u002Fpnas.0404125101",{"id":26,"text":1505,"url":26,"identifiers":1506},"Lipman DJ, Wilbur WJ: Modelling neutral and selective evolution of protein folding. Proc Biol Sci 1991,245(1312):7-11.",{"doi":1507},"10.1098\u002Frspb.1991.0081",{"id":26,"text":1509,"url":26,"identifiers":1510},"Huynen MA, Stadler PF, Fontana W: Smoothness within ruggedness: the role of neutrality in adaptation. Proc Natl Acad Sci U S A 1996,93(1):397-401. 10.1073\u002Fpnas.93.1.397",{"doi":1511},"10.1073\u002Fpnas.93.1.397",{"id":26,"text":1513,"url":26,"identifiers":1514},"Gould SJ, Lewontin RC: The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme. Proc R Soc Lond B Biol Sci 1979,205(1161):581-598.",{"doi":1515},"10.1098\u002Frspb.1979.0086",{"id":26,"text":1517,"url":26,"identifiers":1518},"Wagner A: Robustness, evolvability, and neutrality. FEBS Lett 2005,579(8):1772-1778. 10.1016\u002Fj.febslet.2005.01.063",{"doi":1519},"10.1016\u002Fj.febslet.2005.01.063",{"id":26,"text":1521,"url":26,"identifiers":1522},"Nelson MI, Simonsen L, Viboud C, Miller MA, Taylor J, St. George K, Griesemer SB, Ghedin E, Sengamalay NA, Spiro DJ, Volkov I, Grenfell BT, Lipman DJ, Taubenberger JK, Holmes EC: Stochastic processes are key determinants of the short-term evolution of influenza A virus. PLoS Path 2006., in press:",{},{"id":26,"text":1524,"url":26,"identifiers":1525},"Jin H, Zhou H, Liu H, Chan W, Adhikary L, Mahmood K, Lee MS, Kemble G: Two residues in the hemagglutinin of A\u002FFujian\u002F411\u002F02-like influenza viruses are responsible for antigenic drift from A\u002FPanama\u002F2007\u002F99. Virology 2005,336(1):113-119. 10.1016\u002Fj.virol.2005.03.010",{"doi":1526},"10.1016\u002Fj.virol.2005.03.010",{"id":26,"text":1528,"url":26,"identifiers":1529},"Gulati U, Wu W, Gulati S, Kumari K, Waner JL, Air GM: Mismatched hemagglutinin and neuraminidase specificities in recent human H3N2 influenza viruses. Virology 2005,339(1):12-20. 10.1016\u002Fj.virol.2005.05.009",{"doi":1530},"10.1016\u002Fj.virol.2005.05.009",{"id":26,"text":1532,"url":26,"identifiers":1533},"WHO: Recommended composition of influenza virus vaccines for use in the 1997-1998 season. In Weekly epidemiological record. Volume 72. World Health Organization; 1997:57.",{},{"id":26,"text":1535,"url":26,"identifiers":1536},"WHO: Recommended composition of influenza virus vaccines for use in the 2003–2004 influenza season. In Weekly epidemiological record. Volume 78. WHO; 2003:58.",{},{"id":26,"text":1538,"url":26,"identifiers":1539},"Hardy I, Li Y, Coulthart MB, Goyette N, Boivin G: Molecular evolution of influenza A\u002FH3N2 viruses in the province of Quebec (Canada) during the 1997-2000 period. Virus Res 2001,77(1):89-96. 10.1016\u002FS0168-1702(01)00269-6",{"doi":1540},"10.1016\u002FS0168-1702(01)00269-6",{"id":26,"text":1542,"url":26,"identifiers":1543},"Schweiger B, Zadow I, Heckler R: Antigenic drift and variability of influenza viruses. Med Microbiol Immunol (Berl) 2002,191(3-4):133-138. 10.1007\u002Fs00430-002-0132-3",{"doi":1544},"10.1007\u002Fs00430-002-0132-3",{"id":26,"text":1546,"url":26,"identifiers":1547},"WHO: Recommended composition of influenza virus vaccines for use in the 1999-2000 season. Weekly epidemiological record 1999, 74: 57.",{},{"id":26,"text":1549,"url":26,"identifiers":1550},"Edgar RC: MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 2004, 5: 113. 10.1186\u002F1471-2105-5-113",{"doi":1551},"10.1186\u002F1471-2105-5-113",{"id":26,"text":1553,"url":26,"identifiers":1554},"Swofford D: PAUP* Version 4.Sinauer Associates, Inc.; 2006. [http:\u002F\u002Fpaup.csit.fsu.edu\u002Findex.html]",{},{"id":26,"text":1556,"url":26,"identifiers":1557},"Felsenstein J: Inferring phylogenies from protein sequences by parsimony, distance, and likelihood methods. Methods Enzymol 1996, 266: 418-427.",{"doi":1558},"10.1016\u002FS0076-6879(96)66026-1",{"id":26,"text":1560,"url":26,"identifiers":1561},"Felsenstein J: PHYLIP.[http:\u002F\u002Fevolution.genetics.washington.edu\u002Fphylip.html]",{},{"id":26,"text":1563,"url":26,"identifiers":1564},"Yang Z: PAML.[http:\u002F\u002Fabacus.gene.ucl.ac.uk\u002Fsoftware\u002Fpaml.html]",{},{"id":26,"text":1566,"url":26,"identifiers":1567},"Yang Z: PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci 1997,13(5):555-556.",{},{"id":26,"text":1569,"url":26,"identifiers":1570},"Goldman N, Yang Z: A codon-based model of nucleotide substitution for protein-coding DNA sequences. Mol Biol Evol 1994,11(5):725-736.",{},{"id":26,"text":1572,"url":26,"identifiers":1573},"Yang Z, Nielsen R: Synonymous and nonsynonymous rate variation in nuclear genes of mammals. J Mol Evol 1998,46(4):409-418. 10.1007\u002FPL00006320",{"doi":1574},"10.1007\u002FPL00006320",{"id":26,"text":1576,"url":26,"identifiers":1577},"Wiley DC, Wilson IA, Skehel JJ: Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 1981,289(5796):373-378. 10.1038\u002F289373a0",{"doi":1578},"10.1038\u002F289373a0",{"id":26,"text":1580,"url":26,"identifiers":1581},"Munoz ET, Deem MW: Epitope analysis for influenza vaccine design. Vaccine 2005,23(9):1144-1148. 10.1016\u002Fj.vaccine.2004.08.028",{"doi":1582},"10.1016\u002Fj.vaccine.2004.08.028",{"id":26,"text":1584,"url":26,"identifiers":1585},"Pond SL, Frost SD: Datamonkey: rapid detection of selective pressure on individual sites of codon alignments. Bioinformatics 2005,21(10):2531-2533. 10.1093\u002Fbioinformatics\u002Fbti320",{"doi":1586},"10.1093\u002Fbioinformatics\u002Fbti320",{"id":1588,"createTime":1589,"updateTime":1590,"relativeEntities":1591,"slug":1592,"properties":1593,"entityType":846,"verifyStatus":25,"verifyTime":1611,"verifyNote":969,"syncStatus":28,"languages":1612,"translateLanguages":1613,"viewCount":36,"primaryUrl":1614,"fullTextUrl":26,"authors":1615,"publicationType":912,"publisherRelationship":1677,"citationCount":633,"citationInfo":1705,"publishDate":1707,"publishYear":1708,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1709,"isForceReanalyzing":948},"dadc260f-da73-4f80-9312-e18ade275394","2024-04-14T21:28:37.763+00:00","2025-01-05T12:36:39.542+00:00",[],"Non-homologous-isofunctional-enzymes-A-systematic-analysis-of-alternative-solutions-in-enzyme-evolution",{"mag":1594,"keywords":1596,"pmc":1597,"openalex":1599,"abstract":1601,"title":1604,"pm":1607,"doi":1609},{"VOID":1595},"2041837226",{"VI":1248},{"VOID":1598},"2876114",{"VOID":1600},"W2041837226",{"VI":1602,"EN":1603},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Thông tin nền\u003C\u002Fjats:title>\u003Cjats:p>Các protein không liên hệ về mặt tiến hóa nhưng xúc tác các phản ứng sinh hóa giống nhau thường được gọi là các enzyme tương tự - trái ngược với các enzyme đồng nguồn gốc. Sự tồn tại của nhiều isoform enzyme thay thế, không đồng nguồn gốc, gây ra một vấn đề tiến hóa thú vị; đồng thời cũng làm phức tạp việc tái tạo lại các con đường chuyển hóa dựa trên genom ở nhiều loài sinh vật khác nhau. Năm 1998, một cuộc tìm kiếm hệ thống các enzyme tương tự đã dẫn đến việc xác định 105 số số hiệu ủy ban enzyme (EC), trong đó có hai hoặc nhiều protein không có sự tương đồng về chuỗi được phát hiện với nhau, bao gồm 34 nút EC mà protein được biết (hoặc dự đoán) có cấu trúc gập riêng biệt, cho thấy nguồn gốc tiến hóa độc lập. Trong 12 năm qua, nhiều enzyme đồng chức năng không đồng nguồn gốc khả thi đã được xác định trong các genom mới được giải mã. Hơn nữa, những nỗ lực trong di truyền cấu trúc đã tạo ra sự bao phủ cấu trúc được cải thiện mạnh mẽ của các proteome, cung cấp đánh giá chắc chắn về mối quan hệ (không) đồng nguồn gốc giữa các protein.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C\u002Fjats:title>\u003Cjats:p>Chúng tôi báo cáo kết quả của một cuộc tìm kiếm toàn diện cho các enzyme đồng chức năng không đồng nguồn gốc (NISE) đã thu được 185 nút EC với hai hoặc nhiều protein không có cấu trúc liên quan đã được nghiên cứu thực nghiệm - hoặc được dự đoán. Trong số các bộ NISE này, chỉ có 74 bộ nằm trong danh sách gốc năm 1998. Các phân bổ cấu trúc của NISE cho thấy sự đại diện quá mức của các protein có cấu trúc ống TIM và cấu trúc liên kết nucleotide Rossmann. Từ góc độ chức năng, bộ NISE này giàu các hydrolase, đặc biệt là các hydrolase carbohydrate, và các enzyme tham gia vào việc phòng thủ chống lại căng thẳng oxy hóa.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết luận\u003C\u002Fjats:title>\u003Cjats:p>Các kết quả này chỉ ra rằng ít nhất một số enzyme đồng chức năng không đồng nguồn gốc được tuyển dụng tương đối gần đây từ các gia đình enzyme hoạt động chống lại các chất nền liên quan và có đủ độ linh hoạt để thích ứng với những thay đổi trong độ đặc hiệu của chất nền.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Người đánh giá\u003C\u002Fjats:title>\u003Cjats:p>Bài viết này đã được đánh giá bởi Andrei Osterman, Keith F. Tipton (được đề cử bởi Martijn Huynen) và Igor B. Zhulin. Để xem toàn bộ đánh giá, hãy chuyển đến phần bình luận của người đánh giá.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>Evolutionarily unrelated proteins that catalyze the same biochemical reactions are often referred to as analogous - as opposed to homologous - enzymes. The existence of numerous alternative, non-homologous enzyme isoforms presents an interesting evolutionary problem; it also complicates genome-based reconstruction of the metabolic pathways in a variety of organisms. In 1998, a systematic search for analogous enzymes resulted in the identification of 105 Enzyme Commission (EC) numbers that included two or more proteins without detectable sequence similarity to each other, including 34 EC nodes where proteins were known (or predicted) to have distinct structural folds, indicating independent evolutionary origins. In the past 12 years, many putative non-homologous isofunctional enzymes were identified in newly sequenced genomes. In addition, efforts in structural genomics resulted in a vastly improved structural coverage of proteomes, providing for definitive assessment of (non)homologous relationships between proteins.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>We report the results of a comprehensive search for non-homologous isofunctional enzymes (NISE) that yielded 185 EC nodes with two or more experimentally characterized - or predicted - structurally unrelated proteins. Of these NISE sets, only 74 were from the original 1998 list. Structural assignments of the NISE show over-representation of proteins with the TIM barrel fold and the nucleotide-binding Rossmann fold. From the functional perspective, the set of NISE is enriched in hydrolases, particularly carbohydrate hydrolases, and in enzymes involved in defense against oxidative stress.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>These results indicate that at least some of the non-homologous isofunctional enzymes were recruited relatively recently from enzyme families that are active against related substrates and are sufficiently flexible to accommodate changes in substrate specificity.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Reviewers\u003C\u002Fjats:title>\u003Cjats:p>This article was reviewed by Andrei Osterman, Keith F. Tipton (nominated by Martijn Huynen) and Igor B. Zhulin. For the full reviews, go to the Reviewers' comments section.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"VI":1605,"EN":1606},"Các enzyme đồng chức năng không đồng nguồn gốc: Phân tích hệ thống về các giải pháp thay thế trong tiến hóa enzyme","Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution",{"VOID":1608},"20433725",{"VOID":1610},"10.1186\u002F1745-6150-5-31","2024-12-31T15:54:15.728+00:00",[102],[101],"https:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-5-31",[1616,1634,1647,1663],{"id":1617,"sortIndex":59,"researcher":26,"roles":1618,"affiliations":1619,"properties":1630},"f4b4c2b8-3418-4d6a-9103-63d20bad770e",[],[1620],{"id":26,"sortIndex":36,"affiliation":1621,"properties":26},{"id":1622,"createTime":1623,"updateTime":1624,"relativeEntities":1625,"slug":1626,"properties":1627,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"91179b2a-90fa-402f-a60d-3b0f86d81d2c","2023-12-28T12:13:55.703+00:00","2024-12-30T07:16:40.404+00:00",[],"National-Center-for-Biotechnology-Information-National-Library-of-Medicine-National-Institutes-of-Health-Bethesda-Maryland-20894-USA",{"title":1628},{"VI":1629},"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA",{"openalex":1631,"orcid":1632,"title":1633},{"VOID":1357},{"VOID":1359},{"EN":1361},{"id":1635,"sortIndex":114,"researcher":26,"roles":1636,"affiliations":1637,"properties":1643},"165ad60f-117f-48df-93af-693d4777ed58",[],[1638],{"id":26,"sortIndex":36,"affiliation":1639,"properties":26},{"id":1622,"createTime":1623,"updateTime":1624,"relativeEntities":1640,"slug":1626,"properties":1641,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1642},{"VI":1629},{"openalex":1644,"orcid":1645,"title":1646},{"VOID":1284},{"VOID":1286},{"EN":1288},{"id":1648,"sortIndex":115,"researcher":26,"roles":1649,"affiliations":1650,"properties":1656},"b51f492e-3814-449b-9f17-52e48e5d8155",[],[1651],{"id":26,"sortIndex":36,"affiliation":1652,"properties":26},{"id":1622,"createTime":1623,"updateTime":1624,"relativeEntities":1653,"slug":1626,"properties":1654,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1655},{"VI":1629},{"openalex":1657,"orcid":1659,"title":1661},{"VOID":1658},"A5077552473",{"VOID":1660},"https:\u002F\u002Forcid.org\u002F0000-0002-2265-5572",{"EN":1662},"Michael Y. Galperin",{"id":1664,"sortIndex":36,"researcher":26,"roles":1665,"affiliations":1666,"properties":1672},"514b0514-a150-4a49-bc6c-bd2851a733bc",[],[1667],{"id":26,"sortIndex":36,"affiliation":1668,"properties":26},{"id":1622,"createTime":1623,"updateTime":1624,"relativeEntities":1669,"slug":1626,"properties":1670,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1671},{"VI":1629},{"openalex":1673,"title":1675},{"VOID":1674},"A5071426268",{"EN":1676},"Marina V. Omelchenko",{"url":26,"publisher":1678,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1679,"slug":663,"properties":1680,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1683,"manageAffiliations":1684,"indexDatabases":1685,"url":26,"thumbnailPath":26,"statistic":1700,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1681,"title":1682},{"VOID":666},{"EN":668},[],[],[1686,1693],{"id":764,"indexDatabase":1687,"url":779,"indexYears":26,"academicFieldIds":1692,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":1688,"label":1689,"description":1690,"key":775,"publicationTags":1691,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":1694,"url":753,"indexYears":754,"academicFieldIds":1699,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":1695,"label":1696,"description":1697,"key":750,"publicationTags":1698,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":1701,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":1702,"totalCitation":793,"totalCitationByYear":1703,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":1704,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"total":633,"publishYear":26,"statisticByYear":1706},{"2012":52,"2013":50,"2014":52,"2015":356,"2016":135,"2017":50,"2018":135,"2019":51,"2020":50,"2021":356,"2022":162,"2023":135},"2010-12-01",2010,[1710,1714,1718,1721,1725,1728,1732,1736,1740,1744,1748,1752,1756,1760,1764,1768,1772,1776,1780,1784,1788,1792,1796,1800,1804,1808,1812,1816,1820,1824,1828,1832,1836,1840,1844,1848,1852,1856,1860,1864,1868,1871,1875,1879,1883,1886,1889,1892,1896,1900,1904,1908,1912,1916,1920,1923,1927,1931,1935,1939,1943,1947,1951,1955,1959,1963,1967,1971,1975,1979,1983,1987,1991,1995,1999,2003,2007,2011,2015,2019,2023,2027,2031],{"id":26,"text":1711,"url":26,"identifiers":1712},"Doolittle RF: Convergent evolution: the need to be explicit. Trends Biochem Sci. 1994, 19: 15-18. 10.1016\u002F0968-0004(94)90167-8.",{"doi":1713},"10.1016\u002F0968-0004(94)90167-8",{"id":26,"text":1715,"url":26,"identifiers":1716},"Stallings WC, Powers TB, Pattridge KA, Fee JA, Ludwig ML: Iron superoxide dismutase from Escherichia coli at 3.1-Å resolution: a structure unlike that of copper\u002Fzinc protein at both monomer and dimer levels. Proc Natl Acad Sci USA. 1983, 80: 3884-3888. 10.1073\u002Fpnas.80.13.3884.",{"doi":1717},"10.1073\u002Fpnas.80.13.3884",{"id":26,"text":1719,"url":26,"identifiers":1720},"Koonin EV, Galperin MY: Sequence - Evolution - Function. Computational Approaches in Comparative Genomics. 2002, Boston: Kluwer Academic Publishers",{},{"id":26,"text":1722,"url":26,"identifiers":1723},"Fitch WM: Distinguishing homologous from analogous proteins. Syst Zool. 1970, 19: 99-113. 10.2307\u002F2412448.",{"doi":1724},"10.2307\u002F2412448",{"id":26,"text":1726,"url":26,"identifiers":1727},"Florkin M: Concepts of molecular biosemiotics and of molecular evolution. Comprehensive Biochemistry. Edited by: Florkin M, Stolz EH. 1974, Amsterdam, the Netherlands: Elsevier, 29A: 1-124.",{},{"id":26,"text":1729,"url":26,"identifiers":1730},"Galperin MY, Walker DR, Koonin EV: Analogous enzymes: independent inventions in enzyme evolution. Genome Res. 1998, 8: 779-790.",{"doi":1731},"10.1101\u002Fgr.8.8.779",{"id":26,"text":1733,"url":26,"identifiers":1734},"Richardson J, Thomas KA, Rubin BH, Richardson DC: Crystal structure of bovine Cu, Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands. Proc Natl Acad Sci USA. 1975, 72: 1349-1353. 10.1073\u002Fpnas.72.4.1349.",{"doi":1735},"10.1073\u002Fpnas.72.4.1349",{"id":26,"text":1737,"url":26,"identifiers":1738},"Wuerges J, Lee JW, Yim YI, Yim HS, Kang SO, Djinovic Carugo K: Crystal structure of nickel-containing superoxide dismutase reveals another type of active site. Proc Natl Acad Sci USA. 2004, 101: 8569-8574. 10.1073\u002Fpnas.0308514101.",{"doi":1739},"10.1073\u002Fpnas.0308514101",{"id":26,"text":1741,"url":26,"identifiers":1742},"Carter C, Thornburg RW: Tobacco nectarin I. Purification and characterization as a germin-like, manganese superoxide dismutase implicated in the defense of floral reproductive tissues. J Biol Chem. 2000, 275: 36726-36733. 10.1074\u002Fjbc.M006461200.",{"doi":1743},"10.1074\u002Fjbc.M006461200",{"id":26,"text":1745,"url":26,"identifiers":1746},"Galperin MY, Koonin EV: Functional genomics and enzyme evolution. Homologous and analogous enzymes encoded in microbial genomes. Genetica. 1999, 106: 159-170. 10.1023\u002FA:1003705601428.",{"doi":1747},"10.1023\u002FA:1003705601428",{"id":26,"text":1749,"url":26,"identifiers":1750},"Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B, Bork P: Systematic discovery of analogous enzymes in thiamin biosynthesis. Nat Biotechnol. 2003, 21: 790-795. 10.1038\u002Fnbt834.",{"doi":1751},"10.1038\u002Fnbt834",{"id":26,"text":1753,"url":26,"identifiers":1754},"Polekhina G, Board PG, Gali RR, Rossjohn J, Parker MW: Molecular basis of glutathione synthetase deficiency and a rare gene permutation event. EMBO J. 1999, 18: 3204-3213. 10.1093\u002Femboj\u002F18.12.3204.",{"doi":1755},"10.1093\u002Femboj\u002F18.12.3204",{"id":26,"text":1757,"url":26,"identifiers":1758},"Claudel-Renard C, Chevalet C, Faraut T, Kahn D: Enzyme-specific profiles for genome annotation: PRIAM. Nucleic Acids Res. 2003, 31: 6633-6639. 10.1093\u002Fnar\u002Fgkg847.",{"doi":1759},"10.1093\u002Fnar\u002Fgkg847",{"id":26,"text":1761,"url":26,"identifiers":1762},"Otto TD, Guimaraes AC, Degrave WM, de Miranda AB: AnEnPi: identification and annotation of analogous enzymes. BMC Bioinformatics. 2008, 9: 544-10.1186\u002F1471-2105-9-544.",{"doi":1763},"10.1186\u002F1471-2105-9-544",{"id":26,"text":1765,"url":26,"identifiers":1766},"Chandonia JM, Brenner SE: The impact of structural genomics: expectations and outcomes. Science. 2006, 311: 347-351. 10.1126\u002Fscience.1121018.",{"doi":1767},"10.1126\u002Fscience.1121018",{"id":26,"text":1769,"url":26,"identifiers":1770},"Terwilliger TC, Stuart D, Yokoyama S: Lessons from structural genomics. Annu Rev Biophys. 2009, 38: 371-383. 10.1146\u002Fannurev.biophys.050708.133740.",{"doi":1771},"10.1146\u002Fannurev.biophys.050708.133740",{"id":26,"text":1773,"url":26,"identifiers":1774},"Huerta C, Borek D, Machius M, Grishin NV, Zhang H: Structure and mechanism of a eukaryotic FMN adenylyltransferase. J Mol Biol. 2009, 389: 388-400. 10.1016\u002Fj.jmb.2009.04.022.",{"doi":1775},"10.1016\u002Fj.jmb.2009.04.022",{"id":26,"text":1777,"url":26,"identifiers":1778},"Vong QP, Cao K, Li HY, Iglesias PA, Zheng Y: Chromosome alignment and segregation regulated by ubiquitination of survivin. Science. 2005, 310: 1499-1504. 10.1126\u002Fscience.1120160.",{"doi":1779},"10.1126\u002Fscience.1120160",{"id":26,"text":1781,"url":26,"identifiers":1782},"Pentz ES, Wright TR: Drosophila melanogaster diphenol oxidase A2: gene structure and homology with the mouse mast-cell tum-transplantation antigen, P91A. Gene. 1991, 103: 239-242. 10.1016\u002F0378-1119(91)90279-K.",{"doi":1783},"10.1016\u002F0378-1119(91)90279-K",{"id":26,"text":1785,"url":26,"identifiers":1786},"Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, Katayama T, Kawashima S, Okuda S, Tokimatsu T, Yamanishi Y: KEGG for linking genomes to life and the environment. Nucleic Acids Res. 2008, 36: D480-D484. 10.1093\u002Fnar\u002Fgkm882.",{"doi":1787},"10.1093\u002Fnar\u002Fgkm882",{"id":26,"text":1789,"url":26,"identifiers":1790},"Kotera M, Okuno Y, Hattori M, Goto S, Kanehisa M: Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions. J Am Chem Soc. 2004, 126: 16487-16498. 10.1021\u002Fja0466457.",{"doi":1791},"10.1021\u002Fja0466457",{"id":26,"text":1793,"url":26,"identifiers":1794},"Yamanishi Y, Hattori M, Kotera M, Goto S, Kanehisa M: E-zyme: predicting potential EC numbers from the chemical transformation pattern of substrate-product pairs. Bioinformatics. 2009, 25: i179-i186. 10.1093\u002Fbioinformatics\u002Fbtp223.",{"doi":1795},"10.1093\u002Fbioinformatics\u002Fbtp223",{"id":26,"text":1797,"url":26,"identifiers":1798},"Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA: Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate\u002Fgalactarate catabolic pathway in Escherichia coli. Biochemistry. 1998, 37: 14369-14375. 10.1021\u002Fbi981124f.",{"doi":1799},"10.1021\u002Fbi981124f",{"id":26,"text":1801,"url":26,"identifiers":1802},"Kehrer D, Ahmed H, Brinkmann H, Siebers B: Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes. BMC Genomics. 2007, 8: 301-10.1186\u002F1471-2164-8-301.",{"doi":1803},"10.1186\u002F1471-2164-8-301",{"id":26,"text":1805,"url":26,"identifiers":1806},"Andreeva A, Howorth D, Chandonia JM, Brenner SE, Hubbard TJ, Chothia C, Murzin AG: Data growth and its impact on the SCOP database: new developments. Nucleic Acids Res. 2008, 36: D419-D425. 10.1093\u002Fnar\u002Fgkm993.",{"doi":1807},"10.1093\u002Fnar\u002Fgkm993",{"id":26,"text":1809,"url":26,"identifiers":1810},"Tatusov RL, Galperin MY, Natale DA, Koonin EV: The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res. 2000, 28: 33-36. 10.1093\u002Fnar\u002F28.1.33.",{"doi":1811},"10.1093\u002Fnar\u002F28.1.33",{"id":26,"text":1813,"url":26,"identifiers":1814},"Doolittle RF, Feng DF, Johnson MS, McClure MA: Relationships of human protein sequences to those of other organisms. Cold Spring Harbor Symp Quant Biol. 1986, 51: 447-455.",{"doi":1815},"10.1101\u002FSQB.1986.051.01.054",{"id":26,"text":1817,"url":26,"identifiers":1818},"Wierenga RK: The TIM-barrel fold: a versatile framework for efficient enzymes. FEBS Lett. 2001, 492: 193-198. 10.1016\u002FS0014-5793(01)02236-0.",{"doi":1819},"10.1016\u002FS0014-5793(01)02236-0",{"id":26,"text":1821,"url":26,"identifiers":1822},"Nagano N, Orengo CA, Thornton JM: One fold with many functions: the evolutionary relationships between TIM barrel families based on their sequences, structures and functions. J Mol Biol. 2002, 321: 741-765. 10.1016\u002FS0022-2836(02)00649-6.",{"doi":1823},"10.1016\u002FS0022-2836(02)00649-6",{"id":26,"text":1825,"url":26,"identifiers":1826},"Jensen RA: Enzyme recruitment in evolution of new function. Annu Rev Microbiol. 1976, 30: 409-425. 10.1146\u002Fannurev.mi.30.100176.002205.",{"doi":1827},"10.1146\u002Fannurev.mi.30.100176.002205",{"id":26,"text":1829,"url":26,"identifiers":1830},"Finn RD, Tate J, Mistry J, Coggill PC, Sammut SJ, Hotz HR, Ceric G, Forslund K, Eddy SR, Sonnhammer EL, Bateman A: The Pfam protein families database. Nucleic Acids Res. 2008, 36: D281-D288. 10.1093\u002Fnar\u002Fgkm960.",{"doi":1831},"10.1093\u002Fnar\u002Fgkm960",{"id":26,"text":1833,"url":26,"identifiers":1834},"Leipe DD, Koonin EV, Aravind L: Evolution and classification of P-loop kinases and related proteins. J Mol Biol. 2003, 333: 781-815. 10.1016\u002Fj.jmb.2003.08.040.",{"doi":1835},"10.1016\u002Fj.jmb.2003.08.040",{"id":26,"text":1837,"url":26,"identifiers":1838},"Daugherty M, Vonstein V, Overbeek R, Osterman A: Archaeal shikimate kinase, a new member of the GHMP-kinase family. J Bacteriol. 2001, 183: 292-300. 10.1128\u002FJB.183.1.292-300.2001.",{"doi":1839},"10.1128\u002FJB.183.1.292-300.2001",{"id":26,"text":1841,"url":26,"identifiers":1842},"Ibba M, Morgan S, Curnow AW, Pridmore DR, Vothknecht UC, Gardner W, Lin W, Woese CR, Söll D: A euryarchaeal lysyl-tRNA synthetase: resemblance to class I synthetases. Science. 1997, 278: 1119-1122. 10.1126\u002Fscience.278.5340.1119.",{"doi":1843},"10.1126\u002Fscience.278.5340.1119",{"id":26,"text":1845,"url":26,"identifiers":1846},"Ibba M, Bono JL, Rosa PA, Söll D: Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi. Proc Natl Acad Sci USA. 1997, 94: 14383-14388. 10.1073\u002Fpnas.94.26.14383.",{"doi":1847},"10.1073\u002Fpnas.94.26.14383",{"id":26,"text":1849,"url":26,"identifiers":1850},"Verhees CH, Huynen MA, Ward DE, Schiltz E, de Vos WM, Oost van der J: The phosphoglucose isomerase from the hyperthermophilic archaeon Pyrococcus furiosus is a unique glycolytic enzyme that belongs to the cupin superfamily. J Biol Chem. 2001, 276: 40926-40932. 10.1074\u002Fjbc.M104603200.",{"doi":1851},"10.1074\u002Fjbc.M104603200",{"id":26,"text":1853,"url":26,"identifiers":1854},"Hansen T, Oehlmann M, Schönheit P: Novel type of glucose-6-phosphate isomerase in the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol. 2001, 183: 3428-3435. 10.1128\u002FJB.183.11.3428-3435.2001.",{"doi":1855},"10.1128\u002FJB.183.11.3428-3435.2001",{"id":26,"text":1857,"url":26,"identifiers":1858},"van Nimwegen E: Scaling laws in the functional content of genomes. Trends Genet. 2003, 19: 479-484. 10.1016\u002FS0168-9525(03)00203-8.",{"doi":1859},"10.1016\u002FS0168-9525(03)00203-8",{"id":26,"text":1861,"url":26,"identifiers":1862},"Molina N, van Nimwegen E: Scaling laws in functional genome content across prokaryotic clades and lifestyles. Trends Genet. 2009, 25: 243-247. 10.1016\u002Fj.tig.2009.04.004.",{"doi":1863},"10.1016\u002Fj.tig.2009.04.004",{"id":26,"text":1865,"url":26,"identifiers":1866},"Galperin MY, Koonin EV: 'Conserved hypothetical' proteins: prioritization of targets for experimental study. Nucleic Acids Res. 2004, 32: 5452-5463. 10.1093\u002Fnar\u002Fgkh885.",{"doi":1867},"10.1093\u002Fnar\u002Fgkh885",{"id":26,"text":1869,"url":26,"identifiers":1870},"Jensen RA: Evolution of metabolic pathways in enteric bacteria. Escherichia coli and Salmonella: cellular and molecular biology. Edited by: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE. 1996, Washington, D.C.: ASM Press, 2649-2662.",{},{"id":26,"text":1872,"url":26,"identifiers":1873},"Jacob F: Evolution and tinkering. Science. 1977, 196: 1161-1166. 10.1126\u002Fscience.860134.",{"doi":1874},"10.1126\u002Fscience.860134",{"id":26,"text":1876,"url":26,"identifiers":1877},"Pal C, Papp B, Lercher MJ: Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. Nat Genet. 2005, 37: 1372-1375. 10.1038\u002Fng1686.",{"doi":1878},"10.1038\u002Fng1686",{"id":26,"text":1880,"url":26,"identifiers":1881},"Koonin EV, Wolf YI: Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world. Nucleic Acids Res. 2008, 36: 6688-6719. 10.1093\u002Fnar\u002Fgkn668.",{"doi":1882},"10.1093\u002Fnar\u002Fgkn668",{"id":26,"text":1884,"url":26,"identifiers":1885},"Dixon M, Webb EC: Enzymes. 1958, London, New York: Longmans, Green & Co. and Academic Press",{},{"id":26,"text":1887,"url":26,"identifiers":1888},"Report of the Commission on Enzymes of the International Union of Biochemistry. 1961, Oxford: Pergamon Press",{},{"id":26,"text":1890,"url":26,"identifiers":1891},"Enzyme Nomenclature 1992: Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes by the Reactions they Catalyse. 1992, San Diego, California: Academic Press",{},{"id":26,"text":1893,"url":26,"identifiers":1894},"Yamanishi Y, Vert JP, Kanehisa M: Supervised enzyme network inference from the integration of genomic data and chemical information. Bioinformatics. 2005, 21 (Suppl 1): i468-i477. 10.1093\u002Fbioinformatics\u002Fbti1012.",{"doi":1895},"10.1093\u002Fbioinformatics\u002Fbti1012",{"id":26,"text":1897,"url":26,"identifiers":1898},"Karp PD: Call for an enzyme genomics initiative. Genome Biol. 2004, 5: 401-10.1186\u002Fgb-2004-5-8-401.",{"doi":1899},"10.1186\u002Fgb-2004-5-8-401",{"id":26,"text":1901,"url":26,"identifiers":1902},"Barrett AJ, Rawlings ND: 'Species' of peptidases. Biol Chem. 2007, 388: 1151-1157. 10.1515\u002FBC.2007.151.",{"doi":1903},"10.1515\u002FBC.2007.151",{"id":26,"text":1905,"url":26,"identifiers":1906},"Rawlings ND, Barrett AJ, Bateman A: MEROPS: the peptidase database. Nucleic Acids Res. 2010, 38: D227-D233. 10.1093\u002Fnar\u002Fgkp971.",{"doi":1907},"10.1093\u002Fnar\u002Fgkp971",{"id":26,"text":1909,"url":26,"identifiers":1910},"Galperin MY, Moroz OV, Wilson KS, Murzin AG: House cleaning, a part of good housekeeping. Mol Microbiol. 2006, 59: 5-19. 10.1111\u002Fj.1365-2958.2005.04950.x.",{"doi":1911},"10.1111\u002Fj.1365-2958.2005.04950.x",{"id":26,"text":1913,"url":26,"identifiers":1914},"Kuznetsova E, Proudfoot M, Sanders SA, Reinking J, Savchenko A, Arrowsmith CH, Edwards AM, Yakunin AF: Enzyme genomics: Application of general enzymatic screens to discover new enzymes. FEMS Microbiol Rev. 2005, 29: 263-279. 10.1016\u002Fj.femsre.2004.12.006.",{"doi":1915},"10.1016\u002Fj.fmrre.2004.12.006",{"id":26,"text":1917,"url":26,"identifiers":1918},"Bairoch A: The ENZYME database in 2000. Nucleic Acids Res. 2000, 28: 304-305. 10.1093\u002Fnar\u002F28.1.304.",{"doi":1919},"10.1093\u002Fnar\u002F28.1.304",{"id":26,"text":1921,"url":26,"identifiers":1922},"ENZYME database. [ftp:\u002F\u002Fftp.expasy.org\u002Fdatabases\u002Fenzyme]",{},{"id":26,"text":1924,"url":26,"identifiers":1925},"Sayers EW, Barrett T, Benson DA, Bryant SH, Canese K, Chetvernin V, Church DM, DiCuccio M, Edgar R, Federhen S, Feolo M, Geer LY, Helmberg W, Kapustin Y, Landsman D, Lipman DJ, Madden TL, Maglott DR, Miller V, Mizrachi I, Ostell J, Pruitt KD, Schuler GD, Sequeira E, Sherry ST, Shumway M, Sirotkin K, Souvorov A, Starchenko G, Tatusova TA, Wagner L, Yaschenko E, Ye J: Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 2009, 37: D5-D15. 10.1093\u002Fnar\u002Fgkn741.",{"doi":1926},"10.1093\u002Fnar\u002Fgkn741",{"id":26,"text":1928,"url":26,"identifiers":1929},"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25: 3389-3402. 10.1093\u002Fnar\u002F25.17.3389.",{"doi":1930},"10.1093\u002Fnar\u002F25.17.3389",{"id":26,"text":1932,"url":26,"identifiers":1933},"The UniProt Consortium: The Universal Protein Resource (UniProt) 2009. Nucleic Acids Res. 2009, 37: D169-D174. 10.1093\u002Fnar\u002Fgkn664.",{"doi":1934},"10.1093\u002Fnar\u002Fgkn664",{"id":26,"text":1936,"url":26,"identifiers":1937},"Cuff AL, Sillitoe I, Lewis T, Redfern OC, Garratt R, Thornton J, Orengo CA: The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies. Nucleic Acids Res. 2009, 37: D310-D314. 10.1093\u002Fnar\u002Fgkn877.",{"doi":1938},"10.1093\u002Fnar\u002Fgkn877",{"id":26,"text":1940,"url":26,"identifiers":1941},"Wilson D, Pethica R, Zhou Y, Talbot C, Vogel C, Madera M, Chothia C, Gough J: SUPERFAMILY--sophisticated comparative genomics, data mining, visualization and phylogeny. Nucleic Acids Res. 2009, 37: D380-D386. 10.1093\u002Fnar\u002Fgkn762.",{"doi":1942},"10.1093\u002Fnar\u002Fgkn762",{"id":26,"text":1944,"url":26,"identifiers":1945},"Krissinel E, Henrick K: Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr. 2004, 60: 2256-2268. 10.1107\u002FS0907444904026460.",{"doi":1946},"10.1107\u002FS0907444904026460",{"id":26,"text":1948,"url":26,"identifiers":1949},"Jobb G, von Haeseler A, Strimmer K: TREEFINDER: a powerful graphical analysis environment for molecular phylogenetics. BMC Evol Biol. 2004, 4: 18-10.1186\u002F1471-2148-4-18.",{"doi":1950},"10.1186\u002F1471-2148-4-18",{"id":26,"text":1952,"url":26,"identifiers":1953},"Whelan S, Goldman N: A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Mol Biol Evol. 2001, 18: 691-699.",{"doi":1954},"10.1093\u002Foxfordjournals.molbev.a003851",{"id":26,"text":1956,"url":26,"identifiers":1957},"Pinchuk GE, Rodionov DA, Yang C, Li X, Osterman AL, Dervyn E, Geydebrekht OV, Reed SB, Romine MF, Collart FR, Scott JH, Fredrickson JK, Beliaev AS: Genomic reconstruction of Shewanella oneidensis MR-1 metabolism reveals a previously uncharacterized machinery for lactate utilization. Proc Natl Acad Sci USA. 2009, 106: 2874-2879. 10.1073\u002Fpnas.0806798106.",{"doi":1958},"10.1073\u002Fpnas.0806798106",{"id":26,"text":1960,"url":26,"identifiers":1961},"Sadreyev RI, Kim BH, Grishin NV: Discrete-continuous duality of protein structure space. Curr Opin Struct Biol. 2009, 19: 321-328. 10.1016\u002Fj.sbi.2009.04.009.",{"doi":1962},"10.1016\u002Fj.sbi.2009.04.009",{"id":26,"text":1964,"url":26,"identifiers":1965},"Alva V, Remmert M, Biegert A, Lupas AN, Söding J: A galaxy of folds. Protein Sci. 2010, 19: 124-130.",{"doi":1966},"10.1002\u002Fpro.297",{"id":26,"text":1968,"url":26,"identifiers":1969},"Zhang Y, Thiele I, Weekes D, Li Z, Jaroszewski L, Ginalski K, Deacon AM, Wooley J, Lesley SA, Wilson IA, Palsson B, Osterman A, Godzik A: Three-dimensional structural view of the central metabolic network of Thermotoga maritima. Science. 2009, 325: 1544-1549. 10.1126\u002Fscience.1174671.",{"doi":1970},"10.1126\u002Fscience.1174671",{"id":26,"text":1972,"url":26,"identifiers":1973},"Jeffery CJ: Moonlighting proteins--an update. Mol BioSyst. 2009, 5: 345-350. 10.1039\u002Fb900658n.",{"doi":1974},"10.1039\u002Fb900658n",{"id":26,"text":1976,"url":26,"identifiers":1977},"Gancedo C, Flores CL: Moonlighting proteins in yeasts. Microbiol Mol Biol Rev. 2008, 72: 197-210. 10.1128\u002FMMBR.00036-07.",{"doi":1978},"10.1128\u002FMMBR.00036-07",{"id":26,"text":1980,"url":26,"identifiers":1981},"Huberts DH, Klei van der IJ: Moonlighting proteins: An intriguing mode of multitasking. Biochim Biophys Acta. 2010, 1803: 520-5. 10.1016\u002Fj.bbamcr.2010.01.022.",{"doi":1982},"10.1016\u002Fj.bbamcr.2010.01.022",{"id":26,"text":1984,"url":26,"identifiers":1985},"Jeffery CJ: Moonlighting proteins. Trends Biochem Sci. 1999, 24: 8-11. 10.1016\u002FS0968-0004(98)01335-8.",{"doi":1986},"10.1016\u002FS0968-0004(98)01335-8",{"id":26,"text":1988,"url":26,"identifiers":1989},"Meyer-Siegler K, Mauro DJ, Seal G, Wurzer J, deRiel JK, Sirover MA: A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci USA. 1991, 88: 8460-8464. 10.1073\u002Fpnas.88.19.8460.",{"doi":1990},"10.1073\u002Fpnas.88.19.8460",{"id":26,"text":1992,"url":26,"identifiers":1993},"Caradonna S, Ladner R, Hansbury M, Kosciuk M, Lynch F, Muller S: Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases. Exp Cell Res. 1996, 222: 345-359. 10.1006\u002Fexcr.1996.0044.",{"doi":1994},"10.1006\u002Fexcr.1996.0044",{"id":26,"text":1996,"url":26,"identifiers":1997},"Kirschner K, Bisswanger H: Multifunctional proteins. Annu Rev Biochem. 1976, 45: 143-166. 10.1146\u002Fannurev.bi.45.070176.001043.",{"doi":1998},"10.1146\u002Fannurev.bi.45.070176.001043",{"id":26,"text":2000,"url":26,"identifiers":2001},"Copley SD: Enzymes with extra talents: moonlighting functions and catalytic promiscuity. Curr Opin Chem Biol. 2003, 7: 265-272. 10.1016\u002FS1367-5931(03)00032-2.",{"doi":2002},"10.1016\u002FS1367-5931(03)00032-2",{"id":26,"text":2004,"url":26,"identifiers":2005},"Diella F, Cameron S, Gemund C, Linding R, Via A, Kuster B, Sicheritz-Ponten T, Blom N, Gibson TJ: Phospho.ELM: a database of experimentally verified phosphorylation sites in eukaryotic proteins. BMC Bioinformatics. 2004, 5: 79-10.1186\u002F1471-2105-5-79.",{"doi":2006},"10.1186\u002F1471-2105-5-79",{"id":26,"text":2008,"url":26,"identifiers":2009},"Gerlt JA, Babbitt PC, Rayment I: Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity. Arch Biochem Biophys. 2005, 433: 59-70. 10.1016\u002Fj.abb.2004.07.034.",{"doi":2010},"10.1016\u002Fj.abb.2004.07.034",{"id":26,"text":2012,"url":26,"identifiers":2013},"Vick JE, Gerlt JA: Evolutionary potential of b\u002Fa8-barrels: stepwise evolution of a \"new\" reaction in the enolase superfamily. Biochemistry. 2007, 46: 14589-14597. 10.1021\u002Fbi7019063.",{"doi":2014},"10.1021\u002Fbi7019063",{"id":26,"text":2016,"url":26,"identifiers":2017},"Holliday GL, Almonacid DE, Bartlett GJ, O'Boyle NM, Torrance JW, Murray-Rust P, Mitchell JB, Thornton JM: MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms. Nucleic Acids Res. 2007, 35: D515-D520. 10.1093\u002Fnar\u002Fgkl774.",{"doi":2018},"10.1093\u002Fnar\u002Fgkl774",{"id":26,"text":2020,"url":26,"identifiers":2021},"Andreini C, Bertini I, Cavallaro G, Holliday GL, Thornton JM: Metal-MACiE: a database of metals involved in biological catalysis. Bioinformatics. 2009, 25: 2088-2089. 10.1093\u002Fbioinformatics\u002Fbtp256.",{"doi":2022},"10.1093\u002Fbioinformatics\u002Fbtp256",{"id":26,"text":2024,"url":26,"identifiers":2025},"O'Boyle NM, Holliday GL, Almonacid DE, Mitchell JB: Using reaction mechanism to measure enzyme similarity. J Mol Biol. 2007, 368: 1484-1499. 10.1016\u002Fj.jmb.2007.02.065.",{"doi":2026},"10.1016\u002Fj.jmb.2007.02.065",{"id":26,"text":2028,"url":26,"identifiers":2029},"Paley SM, Karp PD: Evaluation of computational metabolic-pathway predictions for Helicobacter pylori. Bioinformatics. 2002, 18: 715-724. 10.1093\u002Fbioinformatics\u002F18.5.715.",{"doi":2030},"10.1093\u002Fbioinformatics\u002F18.5.715",{"id":26,"text":2032,"url":26,"identifiers":2033},"Chang A, Scheer M, Grote A, Schomburg I, Schomburg D: BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009. Nucleic Acids Res. 2009, 37: D588-D592. 10.1093\u002Fnar\u002Fgkn820.",{"doi":2034},"10.1093\u002Fnar\u002Fgkn820",{"id":2036,"createTime":2037,"updateTime":2038,"relativeEntities":2039,"slug":2040,"properties":2041,"entityType":846,"verifyStatus":25,"verifyTime":2059,"verifyNote":969,"syncStatus":28,"languages":2060,"translateLanguages":2061,"viewCount":36,"primaryUrl":2062,"fullTextUrl":26,"authors":2063,"publicationType":912,"publisherRelationship":2124,"citationCount":2155,"citationInfo":2156,"publishDate":1396,"publishYear":1397,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2158,"isForceReanalyzing":948},"cac704ac-2b65-43c8-9254-374561568671","2024-04-16T21:11:53.971+00:00","2025-01-05T12:37:38.207+00:00",[],"The-signaling-helix-a-common-functional-theme-in-diverse-signaling-proteins",{"mag":2042,"keywords":2044,"pmc":2045,"openalex":2047,"abstract":2049,"title":2052,"pm":2055,"doi":2057},{"VOID":2043},"2134895747",{"VI":1248},{"VOID":2046},"1592074",{"VOID":2048},"W2134895747",{"VI":2050,"EN":2051},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Thông tin nền\u003C\u002Fjats:title>\n            \u003Cjats:p>Cơ chế truyền tín hiệu giữa miền thụ thể và miền hiệu ứng trong các protein tín hiệu đa miền chưa được hiểu rõ.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Sử dụng các phương pháp phân tích chuỗi nhạy cảm, chúng tôi đã xác định được một đoạn xoắn helix bảo tồn dài khoảng 40 amino acid trong nhiều loại protein tín hiệu, bao gồm nhiều kinase histidine cảm biến như Sln1p và cyclase guanylyl thụ thể như thụ thể peptid natriatri và thụ thể nitric oxide. Chúng tôi đặt tên cho đoạn xoắn này là helix tín hiệu (S)-helix và trình bày bằng chứng rằng nó hình thành một yếu tố cuộn xoắn song song mới, khác biệt với các đoạn xoắn helix đã biết trước đó trong các protein tín hiệu như mô-đun phosphotransfer Dimerization-Histidine của các kinase histidine, miền nội bào của các thụ thể hóa cảm ứng, các liên kết helical miền inter-GAF và mô-đun HAMP α-helix. Phân tích cấu trúc miền đã cho phép chúng tôi tái dựng đồ thị hàng xóm của miền cho S-helix, cho thấy rằng S-helix hầu như luôn xuất hiện giữa hai miền tín hiệu. Một số mẫu rõ ràng trong hàng xóm miền của S-helix cũng trở nên rõ ràng từ đồ thị. Nó thường tách rời các miền cảm biến đầu N đa dạng khỏi các miền tín hiệu xúc tác đầu C như kinase histidine, cyclase cNMP, phosphatase PP2C, ATPase AAA+ giống NtrC và cyclase diguanylate. Nó cũng có thể xảy ra giữa hai miền cảm biến như các miền PAS và đôi khi giữa miền liên kết DNA HTH và một miền cảm biến. Mẫu bảo tồn chuỗi của S-helix cho thấy sự hiện diện của một nhóm riêng biệt các amino acid phân cực trong các vị trí giao diện dimer bên trong bảy amino acid trung tâm của cuộn xoắn được hình thành bởi S-helix.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Kết hợp các quan sát này với các nghiên cứu đột biến đã được báo cáo trước đó về các protein chứa S-helix khác nhau, chúng tôi đề xuất rằng nó hoạt động như một công tắc ngăn chặn sự kích hoạt liên tục của các miền tín hiệu tiếp theo liên kết. Tuy nhiên, khi xảy ra các thay đổi cấu hình cụ thể do sự gắn kết của ligands hoặc các tín hiệu cảm biến khác ở miền phía trên liên kết, nó truyền đạt tín hiệu đến miền phía dưới. Do đó, S-helix đại diện cho một trong những chủ đề chức năng phổ biến nhất liên quan đến luồng tín hiệu giữa các mô-đun trong các protein tín hiệu đa miền thuộc loại prokaryote đa dạng.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>The mechanism by which the signals are transmitted between receptor and effector domains in multi-domain signaling proteins is poorly understood.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>Using sensitive sequence analysis methods we identify a conserved helical segment of around 40 residues in a wide range of signaling proteins, including numerous sensor histidine kinases such as Sln1p, and receptor guanylyl cyclases such as the atrial natriuretic peptide receptor and nitric oxide receptors. We term this helical segment the signaling (S)-helix and present evidence that it forms a novel parallel coiled-coil element, distinct from previously known helical segments in signaling proteins, such as the Dimerization-Histidine phosphotransfer module of histidine kinases, the intra-cellular domains of the chemotaxis receptors, inter-GAF domain helical linkers and the α-helical HAMP module. Analysis of domain architectures allowed us to reconstruct the domain-neighborhood graph for the S-helix, which showed that the S-helix almost always occurs between two signaling domains. Several striking patterns in the domain neighborhood of the S-helix also became evident from the graph. It most often separates diverse N-terminal sensory domains from various C-terminal catalytic signaling domains such as histidine kinases, cNMP cyclase, PP2C phosphatases, NtrC-like AAA+ ATPases and diguanylate cyclases. It might also occur between two sensory domains such as PAS domains and occasionally between a DNA-binding HTH domain and a sensory domain. The sequence conservation pattern of the S-helix revealed the presence of a unique constellation of polar residues in the dimer-interface positions within the central heptad of the coiled-coil formed by the S-helix.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>Combining these observations with previously reported mutagenesis studies on different S-helix-containing proteins we suggest that it functions as a switch that prevents constitutive activation of linked downstream signaling domains. However, upon occurrence of specific conformational changes due to binding of ligand or other sensory inputs in a linked upstream domain it transmits the signal to the downstream domain. Thus, the S-helix represents one of the most prevalent functional themes involved in the flow of signals between modules in diverse prokaryote-type multi-domain signaling proteins.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Reviewers\u003C\u002Fjats:title>\n            \u003Cjats:p>This article was reviewed by Frank Eisenhaber, Arcady Mushegian and Sandor Pongor.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":2053,"EN":2054},"Helix điều phối: Một chủ đề chức năng phổ biến trong các protein tín hiệu đa dạng","The signaling helix: a common functional theme in diverse signaling proteins",{"VOID":2056},"16953892",{"VOID":2058},"10.1186\u002F1745-6150-1-25","2024-12-30T14:58:04.063+00:00",[102],[101],"https:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-1-25",[2064,2088,2105],{"id":2065,"sortIndex":114,"researcher":26,"roles":2066,"affiliations":2067,"properties":2081},"de7b9e13-10a2-4db8-8696-edd2c2380be1",[],[2068],{"id":2069,"sortIndex":36,"affiliation":2070,"properties":2079},"08226958-3d2b-4f0d-95fe-bd0b5e597ac0",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":2074,"slug":2075,"properties":2076,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2d4a28bc-bc89-4d44-88a2-e4bb6ba3c1df","2024-08-30T08:44:28.568+00:00","2025-02-07T11:45:48.722+00:00",[],"National-Center-for-Biotechnology-Information-National-Library-of-Medicine-National-Institutes-of-Health-Bethesda-MD-20894-USA",{"title":2077},{"EN":2078},"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA",{"title":2080},{"VI":2078},{"openalex":2082,"orcid":2084,"title":2086},{"VOID":2083},"A5026932356",{"VOID":2085},"https:\u002F\u002Forcid.org\u002F0000-0003-0771-253X",{"EN":2087},"L. Aravind",{"id":2089,"sortIndex":115,"researcher":26,"roles":2090,"affiliations":2091,"properties":2100},"97bf6fa4-c193-4f3d-9549-33d85ad78a96",[],[2092],{"id":2093,"sortIndex":36,"affiliation":2094,"properties":2098},"b61cdffa-cc5d-4d1a-bf3d-e05916e96dd4",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":2095,"slug":2075,"properties":2096,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2097},{"EN":2078},{"title":2099},{"VI":2078},{"openalex":2101,"title":2103},{"VOID":2102},"A5067929237",{"EN":2104},"S. Balaji",{"id":2106,"sortIndex":36,"researcher":26,"roles":2107,"affiliations":2108,"properties":2117},"7b20fede-57c5-47ec-9dec-d947e30d7cdb",[],[2109],{"id":2110,"sortIndex":36,"affiliation":2111,"properties":2115},"85d446d5-d2ff-4aa9-bec7-ddc434988d4f",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":2112,"slug":2075,"properties":2113,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2114},{"EN":2078},{"title":2116},{"VI":2078},{"openalex":2118,"orcid":2120,"title":2122},{"VOID":2119},"A5024629664",{"VOID":2121},"https:\u002F\u002Forcid.org\u002F0000-0001-8395-0009",{"EN":2123},"Vivek Anantharaman",{"url":26,"publisher":2125,"properties":2152},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2126,"slug":663,"properties":2127,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2130,"manageAffiliations":2131,"indexDatabases":2132,"url":26,"thumbnailPath":26,"statistic":2147,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":2128,"title":2129},{"VOID":666},{"EN":668},[],[],[2133,2140],{"id":764,"indexDatabase":2134,"url":779,"indexYears":26,"academicFieldIds":2139,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":2135,"label":2136,"description":2137,"key":775,"publicationTags":2138,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":2141,"url":753,"indexYears":754,"academicFieldIds":2146,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":2142,"label":2143,"description":2144,"key":750,"publicationTags":2145,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":2148,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":2149,"totalCitation":793,"totalCitationByYear":2150,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":2151,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"volume":2153,"issue":2154},{"VOID":1232},{"VOID":1232},127,{"total":2155,"publishYear":26,"statisticByYear":2157},{"2012":158,"2013":162,"2014":356,"2015":50,"2016":162,"2017":116,"2018":52,"2019":53,"2020":52,"2021":52,"2022":111,"2023":114,"2024":114},[2159,2163,2167,2171,2175,2179,2182,2186,2190,2194,2198,2202,2206,2210,2214,2218,2222,2226,2230,2234,2238,2242,2246,2250,2254,2258,2262,2266,2270,2274,2278,2282,2286,2290,2294,2298,2302,2306,2310,2313,2317,2321,2325,2329,2333,2337,2341,2344,2348,2352,2356,2360,2364,2367,2370,2374,2378,2382,2386,2390,2394,2398,2402,2406,2409,2413,2417,2421,2425,2429,2433,2436,2440,2444,2447],{"id":26,"text":2160,"url":26,"identifiers":2161},"Ponting CP, Schultz J, Copley RR, Andrade MA, Bork P: Evolution of domain families. Adv Protein Chem 2000, 54: 185-244.",{"doi":2162},"10.1016\u002FS0065-3233(00)54007-8",{"id":26,"text":2164,"url":26,"identifiers":2165},"Aravind L, Anantharaman V, Iyer LM: Evolutionary connections between bacterial and eukaryotic signaling systems: a genomic perspective. Curr Opin Microbiol 2003,6(5):490-497. 10.1016\u002Fj.mib.2003.09.003",{"doi":2166},"10.1016\u002Fj.mib.2003.09.003",{"id":26,"text":2168,"url":26,"identifiers":2169},"Stock AM, Robinson VL, Goudreau PN: Two-component signal transduction. Annu Rev Biochem 2000, 69: 183-215. 10.1146\u002Fannurev.biochem.69.1.183",{"doi":2170},"10.1146\u002Fannurev.biochem.69.1.183",{"id":26,"text":2172,"url":26,"identifiers":2173},"McCue LA, McDonough KA, Lawrence CE: Functional classification of cNMP-binding proteins and nucleotide cyclases with implications for novel regulatory pathways in Mycobacterium tuberculosis. Genome Res 2000,10(2):204-219. 10.1101\u002Fgr.10.2.204",{"doi":2174},"10.1101\u002Fgr.10.2.204",{"id":26,"text":2176,"url":26,"identifiers":2177},"Linder JU, Schultz JE: The class III adenylyl cyclases: multi-purpose signalling modules. Cell Signal 2003,15(12):1081-1089. 10.1016\u002FS0898-6568(03)00130-X",{"doi":2178},"10.1016\u002FS0898-6568(03)00130-X",{"id":26,"text":2180,"url":26,"identifiers":2181},"Galperin MY, Natale DA, Aravind L, Koonin EV: A specialized version of the HD hydrolase domain implicated in signal transduction. J Mol Microbiol Biotechnol 1999,1(2):303-305.",{},{"id":26,"text":2183,"url":26,"identifiers":2184},"Anantharaman V, Aravind L: Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. Trends Biochem Sci 2000,25(11):535-537. 10.1016\u002FS0968-0004(00)01672-8",{"doi":2185},"10.1016\u002FS0968-0004(00)01672-8",{"id":26,"text":2187,"url":26,"identifiers":2188},"Anantharaman V, Aravind L: The CHASE domain: a predicted ligand-binding module in plant cytokinin receptors and other eukaryotic and bacterial receptors. Trends Biochem Sci 2001,26(10):579-582. 10.1016\u002FS0968-0004(01)01968-5",{"doi":2189},"10.1016\u002FS0968-0004(01)01968-5",{"id":26,"text":2191,"url":26,"identifiers":2192},"Anantharaman V, Aravind L: Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria. BMC Genomics 2003,4(1):34. 10.1186\u002F1471-2164-4-34",{"doi":2193},"10.1186\u002F1471-2164-4-34",{"id":26,"text":2195,"url":26,"identifiers":2196},"Mougel C, Zhulin IB: CHASE: an extracellular sensing domain common to transmembrane receptors from prokaryotes, lower eukaryotes and plants. Trends Biochem Sci 2001,26(10):582-584. 10.1016\u002FS0968-0004(01)01969-7",{"doi":2197},"10.1016\u002FS0968-0004(01)01969-7",{"id":26,"text":2199,"url":26,"identifiers":2200},"Zhulin IB, Nikolskaya AN, Galperin MY: Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea. J Bacteriol 2003,185(1):285-294. 10.1128\u002FJB.185.1.285-294.2003",{"doi":2201},"10.1128\u002FJB.185.1.285-294.2003",{"id":26,"text":2203,"url":26,"identifiers":2204},"Tam R, Saier MHJ: Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol Rev 1993,57(2):320-346.",{"doi":2205},"10.1128\u002Fmr.57.2.320-346.1993",{"id":26,"text":2207,"url":26,"identifiers":2208},"O'Hara PJ, Sheppard PO, Thogersen H, Venezia D, Haldeman BA, McGrane V, Houamed KM, Thomsen C, Gilbert TL, Mulvihill ER: The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 1993,11(1):41-52. 10.1016\u002F0896-6273(93)90269-W",{"doi":2209},"10.1016\u002F0896-6273(93)90269-W",{"id":26,"text":2211,"url":26,"identifiers":2212},"Anantharaman V, Koonin EV, Aravind L: Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol 2001,307(5):1271-1292. 10.1006\u002Fjmbi.2001.4508",{"doi":2213},"10.1006\u002Fjmbi.2001.4508",{"id":26,"text":2215,"url":26,"identifiers":2216},"Appleman JA, Chen LL, Stewart V: Probing conservation of HAMP linker structure and signal transduction mechanism through analysis of hybrid sensor kinases. J Bacteriol 2003,185(16):4872-4882. 10.1128\u002FJB.185.16.4872-4882.2003",{"doi":2217},"10.1128\u002FJB.185.16.4872-4882.2003",{"id":26,"text":2219,"url":26,"identifiers":2220},"Aravind L, Ponting CP: The cytoplasmic helical linker domain of receptor histidine kinase and methyl-accepting proteins is common to many prokaryotic signalling proteins. FEMS Microbiol Lett 1999,176(1):111-116. 10.1111\u002Fj.1574-6968.1999.tb13650.x",{"doi":2221},"10.1111\u002Fj.1574-6968.1999.tb13650.x",{"id":26,"text":2223,"url":26,"identifiers":2224},"Williams SB, Stewart V: Functional similarities among two-component sensors and methyl-accepting chemotaxis proteins suggest a role for linker region amphipathic helices in transmembrane signal transduction. Mol Microbiol 1999,33(6):1093-1102. 10.1046\u002Fj.1365-2958.1999.01562.x",{"doi":2225},"10.1046\u002Fj.1365-2958.1999.01562.x",{"id":26,"text":2227,"url":26,"identifiers":2228},"Kim KK, Yokota H, Kim SH: Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor. Nature 1999,400(6746):787-792. 10.1038\u002F23512",{"doi":2229},"10.1038\u002F23512",{"id":26,"text":2231,"url":26,"identifiers":2232},"Singh M, Berger B, Kim PS, Berger JM, Cochran AG: Computational learning reveals coiled coil-like motifs in histidine kinase linker domains. Proc Natl Acad Sci U S A 1998,95(6):2738-2743. 10.1073\u002Fpnas.95.6.2738",{"doi":2233},"10.1073\u002Fpnas.95.6.2738",{"id":26,"text":2235,"url":26,"identifiers":2236},"Lupas AN, Gruber M: The structure of alpha-helical coiled coils. Adv Protein Chem 2005, 70: 37-78. 10.1016\u002FS0065-3233(05)70003-6",{"doi":2237},"10.1016\u002FS0065-3233(05)70003-6",{"id":26,"text":2239,"url":26,"identifiers":2240},"Fassler J, Landsman D, Acharya A, Moll JR, Bonovich M, Vinson C: B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners. Genome Res 2002,12(8):1190-1200. 10.1101\u002Fgr.67902",{"doi":2241},"10.1101\u002Fgr.67902",{"id":26,"text":2243,"url":26,"identifiers":2244},"Weimbs T, Mostov K, Low SH, Hofmann K: A model for structural similarity between different SNARE complexes based on sequence relationships. Trends Cell Biol 1998,8(7):260-262. 10.1016\u002FS0962-8924(98)01285-9",{"doi":2245},"10.1016\u002FS0962-8924(98)01285-9",{"id":26,"text":2247,"url":26,"identifiers":2248},"McLachlan AD, Stewart M: Tropomyosin coiled-coil interactions: evidence for an unstaggered structure. J Mol Biol 1975,98(2):293-304. 10.1016\u002FS0022-2836(75)80119-7",{"doi":2249},"10.1016\u002FS0022-2836(75)80119-7",{"id":26,"text":2251,"url":26,"identifiers":2252},"Marina A, Waldburger CD, Hendrickson WA: Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein. EMBO J 2005,24(24):4247-4259. 10.1038\u002Fsj.emboj.7600886",{"doi":2253},"10.1038\u002Fsj.emboj.7600886",{"id":26,"text":2255,"url":26,"identifiers":2256},"Tomomori C, Tanaka T, Dutta R, Park H, Saha SK, Zhu Y, Ishima R, Liu D, Tong KI, Kurokawa H, Qian H, Inouye M, Ikura M: Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. Nat Struct Biol 1999,6(8):729-734. 10.1038\u002F11495",{"doi":2257},"10.1038\u002F11495",{"id":26,"text":2259,"url":26,"identifiers":2260},"Varughese KI, Madhusudan, Zhou XZ, Whiteley JM, Hoch JA: Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase. Mol Cell 1998,2(4):485-493. 10.1016\u002FS1097-2765(00)80148-3",{"doi":2261},"10.1016\u002FS1097-2765(00)80148-3",{"id":26,"text":2263,"url":26,"identifiers":2264},"Fassler JS, Gray WM, Malone CL, Tao W, Lin H, Deschenes RJ: Activated alleles of yeast SLN1 increase Mcm1-dependent reporter gene expression and diminish signaling through the Hog1 osmosensing pathway. J Biol Chem 1997,272(20):13365-13371. 10.1074\u002Fjbc.272.20.13365",{"doi":2265},"10.1074\u002Fjbc.272.20.13365",{"id":26,"text":2267,"url":26,"identifiers":2268},"Potter LR: Domain analysis of human transmembrane guanylyl cyclase receptors: implications for regulation. Front Biosci 2005, 10: 1205-1220.",{"doi":2269},"10.2741\u002F1613",{"id":26,"text":2271,"url":26,"identifiers":2272},"Tao W, Malone CL, Ault AD, Deschenes RJ, Fassler JS: A cytoplasmic coiled-coil domain is required for histidine kinase activity of the yeast osmosensor, SLN1. Mol Microbiol 2002,43(2):459-473. 10.1046\u002Fj.1365-2958.2002.02757.x",{"doi":2273},"10.1046\u002Fj.1365-2958.2002.02757.x",{"id":26,"text":2275,"url":26,"identifiers":2276},"Iyer LM, Anantharaman V, Aravind L: Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins. BMC Genomics 2003,4(1):5-5. 10.1186\u002F1471-2164-4-5",{"doi":2277},"10.1186\u002F1471-2164-4-5",{"id":26,"text":2279,"url":26,"identifiers":2280},"Sahu SN, Acharya S, Tuminaro H, Patel I, Dudley K, LeClerc JE, Cebula TA, Mukhopadhyay S: The bacterial adaptive response gene, barA, encodes a novel conserved histidine kinase regulatory switch for adaptation and modulation of metabolism in Escherichia coli. Mol Cell Biochem 2003,253(1-2):167-177. 10.1023\u002FA:1026028930203",{"doi":2281},"10.1023\u002FA:1026028930203",{"id":26,"text":2283,"url":26,"identifiers":2284},"Gon S, Jourlin-Castelli C, Theraulaz L, Mejean V: An unsuspected autoregulatory pathway involving apocytochrome TorC and sensor TorS in Escherichia coli. Proc Natl Acad Sci U S A 2001,98(20):11615-11620. 10.1073\u002Fpnas.211330598",{"doi":2285},"10.1073\u002Fpnas.211330598",{"id":26,"text":2287,"url":26,"identifiers":2288},"Whistler CA, Corbell NA, Sarniguet A, Ream W, Loper JE: The two-component regulators GacS and GacA influence accumulation of the stationary-phase sigma factor sigmaS and the stress response in Pseudomonas fluorescens Pf-5. J Bacteriol 1998,180(24):6635-6641.",{"doi":2289},"10.1128\u002FJB.180.24.6635-6641.1998",{"id":26,"text":2291,"url":26,"identifiers":2292},"Hammer BK, Tateda ES, Swanson MS: A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila. Mol Microbiol 2002,44(1):107-118. 10.1046\u002Fj.1365-2958.2002.02884.x",{"doi":2293},"10.1046\u002Fj.1365-2958.2002.02884.x",{"id":26,"text":2295,"url":26,"identifiers":2296},"Stewart V: Biochemical Society Special Lecture. Nitrate- and nitrite-responsive sensors NarX and NarQ of proteobacteria. Biochem Soc Trans 2003,31(Pt 1):1-10.",{"doi":2297},"10.1042\u002Fbst0310001",{"id":26,"text":2299,"url":26,"identifiers":2300},"Cuff JA, Barton GJ: Application of multiple sequence alignment profiles to improve protein secondary structure prediction. Proteins 2000,40(3):502-511. 10.1002\u002F1097-0134(20000815)40:3\u003C502::AID-PROT170>3.0.CO;2-Q",{"doi":2301},"10.1002\u002F1097-0134(20000815)40:3\u003C502::AID-PROT170>3.0.CO;2-Q",{"id":26,"text":2303,"url":26,"identifiers":2304},"Lupas A, Van Dyke M, Stock J: Predicting coiled coils from protein sequences. Science 1991,252(5010):1162-1164.",{"doi":2305},"10.1126\u002Fscience.252.5009.1162",{"id":26,"text":2307,"url":26,"identifiers":2308},"Eddy SR: Profile hidden Markov models. Bioinformatics 1998,14(9):755-763. 10.1093\u002Fbioinformatics\u002F14.9.755",{"doi":2309},"10.1093\u002Fbioinformatics\u002F14.9.755",{"id":26,"text":2311,"url":26,"identifiers":2312},"Schneider TD: Consensus sequence Zen. Appl Bioinformatics 2002,1(3):111-119.",{},{"id":26,"text":2314,"url":26,"identifiers":2315},"Martinez SE, Bruder S, Schultz A, Zheng N, Schultz JE, Beavo JA, Linder JU: Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. Proc Natl Acad Sci U S A 2005,102(8):3082-3087. 10.1073\u002Fpnas.0409913102",{"doi":2316},"10.1073\u002Fpnas.0409913102",{"id":26,"text":2318,"url":26,"identifiers":2319},"Shu CJ, Ulrich LE, Zhulin IB: The NIT domain: a predicted nitrate-responsive module in bacterial sensory receptors. Trends Biochem Sci 2003,28(3):121-124. 10.1016\u002FS0968-0004(03)00032-X",{"doi":2320},"10.1016\u002FS0968-0004(03)00032-X",{"id":26,"text":2322,"url":26,"identifiers":2323},"Methe B, Fraser CM: Roll with the flow: microbial masters of redox chemistry. Trends Microbiol 2004,12(10):439-441. 10.1016\u002Fj.tim.2004.08.004",{"doi":2324},"10.1016\u002Fj.tim.2004.08.004",{"id":26,"text":2326,"url":26,"identifiers":2327},"Wilson EM, Chinkers M: Identification of sequences mediating guanylyl cyclase dimerization. Biochemistry 1995,34(14):4696-4701. 10.1021\u002Fbi00014a025",{"doi":2328},"10.1021\u002Fbi00014a025",{"id":26,"text":2330,"url":26,"identifiers":2331},"Kelsell RE, Gregory-Evans K, Payne AM, Perrault I, Kaplan J, Yang RB, Garbers DL, Bird AC, Moore AT, Hunt DM: Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy. Hum Mol Genet 1998,7(7):1179-1184. 10.1093\u002Fhmg\u002F7.7.1179",{"doi":2332},"10.1093\u002Fhmg\u002F7.7.1179",{"id":26,"text":2334,"url":26,"identifiers":2335},"Ellenberger TE, Brandl CJ, Struhl K, Harrison SC: The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell 1992,71(7):1223-1237. 10.1016\u002FS0092-8674(05)80070-4",{"doi":2336},"10.1016\u002FS0092-8674(05)80070-4",{"id":26,"text":2338,"url":26,"identifiers":2339},"Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA: The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc Natl Acad Sci U S A 2002,99(20):13260-13265. 10.1073\u002Fpnas.192374899",{"doi":2340},"10.1073\u002Fpnas.192374899",{"id":26,"text":2342,"url":26,"identifiers":2343},"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997,25(17):3389-3402. 10.1093\u002Fnar\u002F25.17.3389",{"doi":1930},{"id":26,"text":2345,"url":26,"identifiers":2346},"Aravind L, Koonin EV: Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches. J Mol Biol 1999,287(5):1023-1040. 10.1006\u002Fjmbi.1999.2653",{"doi":2347},"10.1006\u002Fjmbi.1999.2653",{"id":26,"text":2349,"url":26,"identifiers":2350},"Edgar RC: MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 2004,32(5):1792-1797. 10.1093\u002Fnar\u002Fgkh340",{"doi":2351},"10.1093\u002Fnar\u002Fgkh340",{"id":26,"text":2353,"url":26,"identifiers":2354},"Crooks GE, Hon G, Chandonia JM, Brenner SE: WebLogo: a sequence logo generator. Genome Res 2004,14(6):1188-1190. 10.1101\u002Fgr.849004",{"doi":2355},"10.1101\u002Fgr.849004",{"id":26,"text":2357,"url":26,"identifiers":2358},"Nielsen H, Engelbrecht J, Brunak S, von Heijne G: A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Int J Neural Syst 1997,8(5-6):581-599. 10.1142\u002FS0129065797000537",{"doi":2359},"10.1142\u002FS0129065797000537",{"id":26,"text":2361,"url":26,"identifiers":2362},"Nielsen H, Engelbrecht J, Brunak S, von Heijne G: Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng 1997,10(1):1-6. 10.1093\u002Fprotein\u002F10.1.1",{"doi":2363},"10.1093\u002Fprotein\u002F10.1.1",{"id":26,"text":2365,"url":26,"identifiers":2366},"Claros MG, von Heijne G: TopPred II: an improved software for membrane protein structure predictions. Comput Appl Biosci 1994,10(6):685-686.",{},{"id":26,"text":2368,"url":26,"identifiers":2369},"Hofmann K, Stoffel W: TMbase - A database of membrane spanning proteins segments. Biol Chem Hoppe-Seyler 1993, 374: 166.",{},{"id":26,"text":2371,"url":26,"identifiers":2372},"Krogh A, Larsson B, von Heijne G, Sonnhammer EL: Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 2001,305(3):567-580. 10.1006\u002Fjmbi.2000.4315",{"doi":2373},"10.1006\u002Fjmbi.2000.4315",{"id":26,"text":2375,"url":26,"identifiers":2376},"Aravind L, Ponting CP: The GAF domain: an evolutionary link between diverse phototransducing proteins. Trends Biochem Sci 1997,22(12):458-459. 10.1016\u002FS0968-0004(97)01148-1",{"doi":2377},"10.1016\u002FS0968-0004(97)01148-1",{"id":26,"text":2379,"url":26,"identifiers":2380},"Anantharaman V, Aravind L: MEDS and PocR are novel domains with a predicted role in sensing simple hydrocarbon derivatives in prokaryotic signal transduction systems. Bioinformatics 2005,21(12):2805-2811. 10.1093\u002Fbioinformatics\u002Fbti418",{"doi":2381},"10.1093\u002Fbioinformatics\u002Fbti418",{"id":26,"text":2383,"url":26,"identifiers":2384},"Ponting CP, Aravind L: PAS: a multifunctional domain family comes to light. Curr Biol 1997,7(11):674-677. 10.1016\u002FS0960-9822(06)00352-6",{"doi":2385},"10.1016\u002FS0960-9822(06)00352-6",{"id":26,"text":2387,"url":26,"identifiers":2388},"Taylor BL, Zhulin IB: PAS domains: internal sensors of oxygen, redox potential, and light. Microbiol Mol Biol Rev 1999,63(2):479-506.",{"doi":2389},"10.1128\u002FMMBR.63.2.479-506.1999",{"id":26,"text":2391,"url":26,"identifiers":2392},"Tyrrell R, Verschueren KH, Dodson EJ, Murshudov GN, Addy C, Wilkinson AJ: The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement. Structure 1997,5(8):1017-1032. 10.1016\u002FS0969-2126(97)00254-2",{"doi":2393},"10.1016\u002FS0969-2126(97)00254-2",{"id":26,"text":2395,"url":26,"identifiers":2396},"Iyer LM, Leipe DD, Koonin EV, Aravind L: Evolutionary history and higher order classification of AAA+ ATPases. J Struct Biol 2004,146(1-2):11-31. 10.1016\u002Fj.jsb.2003.10.010",{"doi":2397},"10.1016\u002Fj.jsb.2003.10.010",{"id":26,"text":2399,"url":26,"identifiers":2400},"Bateman A, Birney E, Cerruti L, Durbin R, Etwiller L, Eddy SR, Griffiths-Jones S, Howe KL, Marshall M, Sonnhammer EL: The Pfam protein families database. Nucleic Acids Res 2002,30(1):276-280. 10.1093\u002Fnar\u002F30.1.276",{"doi":2401},"10.1093\u002Fnar\u002F30.1.276",{"id":26,"text":2403,"url":26,"identifiers":2404},"Bateman A: The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem Sci 1997,22(1):12-13. 10.1016\u002FS0968-0004(96)30046-7",{"doi":2405},"10.1016\u002FS0968-0004(96)30046-7",{"id":26,"text":2407,"url":26,"identifiers":2408},"Ponting CP: CBS domains in CIC chloride channels implicated in myotonia and nephrolithiasis (kidney stones). J Mol Med 1997,75(3):160-163.",{},{"id":26,"text":2410,"url":26,"identifiers":2411},"Das AK, Helps NR, Cohen PT, Barford D: Crystal structure of the protein serine\u002Fthreonine phosphatase 2C at 2.0 A resolution. Embo J 1996,15(24):6798-6809.",{"doi":2412},"10.1002\u002Fj.1460-2075.1996.tb01071.x",{"id":26,"text":2414,"url":26,"identifiers":2415},"Aravind L, Anantharaman V, Balaji S, Babu MM, Iyer LM: The many faces of the helix-turn-helix domain: transcription regulation and beyond. FEMS Microbiol Rev 2005,29(2):231-262. 10.1016\u002Fj.femsre.2004.12.008",{"doi":2416},"10.1016\u002Fj.fmrre.2004.12.008",{"id":26,"text":2418,"url":26,"identifiers":2419},"Farmer CS, Kurtz DMJ, Liu ZJ, Wang BC, Rose J, Ai J, Sanders-Loehr J: The crystal structures of Phascolopsis gouldii wild type and L98Y methemerythrins: structural and functional alterations of the O2 binding pocket. J Biol Inorg Chem 2001,6(4):418-429. 10.1007\u002Fs007750100218",{"doi":2420},"10.1007\u002Fs007750100218",{"id":26,"text":2422,"url":26,"identifiers":2423},"Pesce A, Couture M, Dewilde S, Guertin M, Yamauchi K, Ascenzi P, Moens L, Bolognesi M: A novel two-over-two alpha-helical sandwich fold is characteristic of the truncated hemoglobin family. Embo J 2000,19(11):2424-2434. 10.1093\u002Femboj\u002F19.11.2424",{"doi":2424},"10.1093\u002Femboj\u002F19.11.2424",{"id":26,"text":2426,"url":26,"identifiers":2427},"Staub E, Fiziev P, Rosenthal A, Hinzmann B: Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. Bioessays 2004,26(5):567-581. 10.1002\u002Fbies.20032",{"doi":2428},"10.1002\u002Fbies.20032",{"id":26,"text":2430,"url":26,"identifiers":2431},"Leipe DD, Koonin EV, Aravind L: STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer. J Mol Biol 2004,343(1):1-28. 10.1016\u002Fj.jmb.2004.08.023",{"doi":2432},"10.1016\u002Fj.jmb.2004.08.023",{"id":26,"text":2434,"url":26,"identifiers":2435},"Batagelj V, Mrvar A: Pajek - Analysis and Visualization of Large Networks. In Graph Drawing Software. Edited by: Jünger M, Mutzel P. Berlin , Springer; 2003:77-103.",{},{"id":26,"text":2437,"url":26,"identifiers":2438},"Marchler-Bauer A, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler GH, Mazumder R, Nikolskaya AN, Panchenko AR, Rao BS, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH: CDD: a curated Entrez database of conserved domain alignments. Nucleic Acids Res 2003,31(1):383-387. 10.1093\u002Fnar\u002Fgkg087",{"doi":2439},"10.1093\u002Fnar\u002Fgkg087",{"id":26,"text":2441,"url":26,"identifiers":2442},"Guex N, Peitsch MC: SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 1997,18(15):2714-2723. 10.1002\u002Felps.1150181505",{"doi":2443},"10.1002\u002Felps.1150181505",{"id":26,"text":2445,"url":26,"identifiers":2446},"DeLano WL: The PyMOL Molecular Graphics System. San Carlos, CA, USA , DeLano Scientific; 2002.",{},{"id":26,"text":2448,"url":26,"identifiers":2449},"Schwede T, Kopp J, Guex N, Peitsch MC: SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res 2003,31(13):3381-3385. 10.1093\u002Fnar\u002Fgkg520",{"doi":2450},"10.1093\u002Fnar\u002Fgkg520",{"id":2452,"createTime":2453,"updateTime":2454,"relativeEntities":2455,"slug":2456,"properties":2457,"entityType":846,"verifyStatus":25,"verifyTime":2454,"verifyNote":969,"syncStatus":28,"languages":2476,"translateLanguages":2477,"viewCount":36,"primaryUrl":2478,"fullTextUrl":26,"authors":2479,"publicationType":912,"publisherRelationship":2530,"citationCount":2562,"citationInfo":2563,"publishDate":2565,"publishYear":2566,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2567,"isForceReanalyzing":948},"3d77d131-f841-4205-ac22-ef083aabcf4a","2024-04-20T01:18:43.819+00:00","2025-02-11T17:26:17.923+00:00",[],"Evolution-of-the-genetic-code-partial-optimization-of-a-random-code-for-robustness-to-translation-error-in-a-rugged-fitness-landscape",{"mag":2458,"keywords":2460,"pmc":2462,"openalex":2464,"abstract":2466,"title":2469,"pm":2472,"doi":2474},{"VOID":2459},"2163198599",{"VI":2461},"mã di truyền, tối ưu hóa, lỗi dịch, mã ngẫu nhiên, tiến hóa",{"VOID":2463},"2211284",{"VOID":2465},"W2163198599",{"VI":2467,"EN":2468},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Đôi nét về vấn đề\u003C\u002Fjats:title>\n            \u003Cjats:p>Bảng mã di truyền tiêu chuẩn có cấu trúc rõ rệt không ngẫu nhiên, với các axit amin tương tự thường được mã hóa bởi các chuỗi codon khác nhau chỉ bằng một sự thay thế nucleotide, thường ở vị trí thứ ba hoặc thứ nhất của codon. Đã có nhiều tranh luận cho rằng cấu trúc này của mã là kết quả của việc tối ưu hóa chọn lọc cho khả năng chống lại các lỗi dịch sao cho việc đọc nhầm trong quá trình dịch có tác động tiêu cực tối thiểu. Thực tế, đã có một số nghiên cứu cho thấy mã chuẩn có tính chống chịu tốt hơn so với phần lớn các mã ngẫu nhiên. Tuy nhiên, vẫn chưa rõ mã chuẩn đã trải qua bao nhiêu sự tiến hóa, mức tối ưu hóa là gì và điểm khởi đầu có khả năng là gì.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>The standard genetic code table has a distinctly non-random structure, with similar amino acids often encoded by codons series that differ by a single nucleotide substitution, typically, in the third or the first position of the codon. It has been repeatedly argued that this structure of the code results from selective optimization for robustness to translation errors such that translational misreading has the minimal adverse effect. Indeed, it has been shown in several studies that the standard code is more robust than a substantial majority of random codes. However, it remains unclear how much evolution the standard code underwent, what is the level of optimization, and what is the likely starting point.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>We explored possible evolutionary trajectories of the genetic code within a limited domain of the vast space of possible codes. Only those codes were analyzed for robustness to translation error that possess the same block structure and the same degree of degeneracy as the standard code. This choice of a small part of the vast space of possible codes is based on the notion that the block structure of the standard code is a consequence of the structure of the complex between the cognate tRNA and the codon in mRNA where the third base of the codon plays a minimum role as a specificity determinant. Within this part of the fitness landscape, a simple evolutionary algorithm, with elementary evolutionary steps comprising swaps of four-codon or two-codon series, was employed to investigate the optimization of codes for the maximum attainable robustness. The properties of the standard code were compared to the properties of four sets of codes, namely, purely random codes, random codes that are more robust than the standard code, and two sets of codes that resulted from optimization of the first two sets. The comparison of these sets of codes with the standard code and its locally optimized version showed that, on average, optimization of random codes yielded evolutionary trajectories that converged at the same level of robustness to translation errors as the optimization path of the standard code; however, the standard code required considerably fewer steps to reach that level than an average random code. When evolution starts from random codes whose fitness is comparable to that of the standard code, they typically reach much higher level of optimization than the standard code, i.e., the standard code is much closer to its local minimum (fitness peak) than most of the random codes with similar levels of robustness. Thus, the standard genetic code appears to be a point on an evolutionary trajectory from a random point (code) about half the way to the summit of the local peak. The fitness landscape of code evolution appears to be extremely rugged, containing numerous peaks with a broad distribution of heights, and the standard code is relatively unremarkable, being located on the slope of a moderate-height peak.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>The standard code appears to be the result of partial optimization of a random code for robustness to errors of translation. The reason the code is not fully optimized could be the trade-off between the beneficial effect of increasing robustness to translation errors and the deleterious effect of codon series reassignment that becomes increasingly severe with growing complexity of the evolving system. Thus, evolution of the code can be represented as a combination of adaptation and frozen accident.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Reviewers\u003C\u002Fjats:title>\n            \u003Cjats:p>This article was reviewed by David Ardell, Allan Drummond (nominated by Laura Landweber), and Rob Knight.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Open Peer Review\u003C\u002Fjats:title>\n            \u003Cjats:p>This article was reviewed by David Ardell, Allan Drummond (nominated by Laura Landweber), and Rob Knight.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":2470,"EN":2471},"Sự tiến hóa của mã di truyền: tối ưu hóa một mã ngẫu nhiên một phần để tăng cường khả năng chống lại lỗi dịch trong một bối cảnh sức khỏe gồ ghề","Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape",{"VOID":2473},"17956616",{"VOID":2475},"10.1186\u002F1745-6150-2-24",[102],[101],"https:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-2-24",[2480,2496,2513],{"id":2481,"sortIndex":114,"researcher":26,"roles":2482,"affiliations":2483,"properties":2492},"1938f706-434a-4cb9-b3a0-77da63e96b64",[],[2484],{"id":2485,"sortIndex":36,"affiliation":2486,"properties":2490},"4fd29b30-28b6-41af-9cbe-33418f5bfb4a",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":2487,"slug":2075,"properties":2488,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2489},{"EN":2078},{"title":2491},{"VI":2078},{"openalex":2493,"orcid":2494,"title":2495},{"VOID":1357},{"VOID":1359},{"EN":1361},{"id":2497,"sortIndex":36,"researcher":26,"roles":2498,"affiliations":2499,"properties":2508},"8d79e11e-bd3d-48e3-b893-96680245c02b",[],[2500],{"id":2501,"sortIndex":36,"affiliation":2502,"properties":2506},"7e9e7a28-bb63-46b6-a284-b54ef578c620",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":2503,"slug":2075,"properties":2504,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2505},{"EN":2078},{"title":2507},{"VI":2078},{"openalex":2509,"title":2511},{"VOID":2510},"A5044414946",{"EN":2512},"Artem S. Novozhilov",{"id":2514,"sortIndex":115,"researcher":26,"roles":2515,"affiliations":2516,"properties":2526},"65930df8-0333-4eb9-89a5-8855c9c3df23",[],[2517],{"id":2518,"sortIndex":36,"affiliation":2519,"properties":2523},"658ded8e-54ca-42ff-903d-ef26e36f46c9",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":2520,"slug":2075,"properties":2521,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2522},{"EN":2078},{"title":2524},{"EN":2525},"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA",{"openalex":2527,"orcid":2528,"title":2529},{"VOID":1284},{"VOID":1286},{"EN":1288},{"url":26,"publisher":2531,"properties":2558},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2532,"slug":663,"properties":2533,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2536,"manageAffiliations":2537,"indexDatabases":2538,"url":26,"thumbnailPath":26,"statistic":2553,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":2534,"title":2535},{"VOID":666},{"EN":668},[],[],[2539,2546],{"id":764,"indexDatabase":2540,"url":779,"indexYears":26,"academicFieldIds":2545,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":2541,"label":2542,"description":2543,"key":775,"publicationTags":2544,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":2547,"url":753,"indexYears":754,"academicFieldIds":2552,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":2548,"label":2549,"description":2550,"key":750,"publicationTags":2551,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":2554,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":2555,"totalCitation":793,"totalCitationByYear":2556,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":2557,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"volume":2559,"issue":2561},{"VOID":2560},"2",{"VOID":1232},103,{"total":2562,"publishYear":26,"statisticByYear":2564},{"2012":114,"2013":135,"2014":162,"2015":111,"2016":111,"2017":116,"2018":356,"2019":50,"2020":162,"2021":52,"2022":52,"2023":50},"2007-12-01",2007,[2568,2572,2576,2580,2583,2587,2591,2595,2599,2603,2607,2611,2615,2618,2622,2626,2630,2634,2637,2641,2645,2649,2653,2657,2661,2665,2669,2673,2677,2681,2684,2688,2692,2696,2700,2704,2708,2712,2716,2720,2724,2728,2732,2736,2740,2744,2748,2752,2756,2760,2764,2768,2772,2776,2779,2783,2787,2791,2795,2799,2803],{"id":26,"text":2569,"url":26,"identifiers":2570},"Nirenberg MW, Jones W, Leder P, Clark BFC, Sly WS, Pestka S: On the Coding of Genetic Information. Cold Spring Harb Symp Quant Biol 1963, 28: 549-558.",{"doi":2571},"10.1101\u002FSQB.1963.028.01.074",{"id":26,"text":2573,"url":26,"identifiers":2574},"Crick FH: Codon--anticodon pairing: the wobble hypothesis. J Mol Biol 1966,19(2):548-555.",{"doi":2575},"10.1016\u002FS0022-2836(66)80022-0",{"id":26,"text":2577,"url":26,"identifiers":2578},"Crick FH: The origin of the genetic code. J Mol Biol 1968,38(3):367-379. 10.1016\u002F0022-2836(68)90392-6",{"doi":2579},"10.1016\u002F0022-2836(68)90392-6",{"id":26,"text":2581,"url":26,"identifiers":2582},"Woese C: The genetic code: the molecular basis for genetic expression. New York , Harper & Row; 1967.",{},{"id":26,"text":2584,"url":26,"identifiers":2585},"Ambrogelly A, Palioura S, Soll D: Natural expansion of the genetic code. Nat Chem Biol 2007,3(1):29-35. 10.1038\u002Fnchembio847",{"doi":2586},"10.1038\u002Fnchembio847",{"id":26,"text":2588,"url":26,"identifiers":2589},"Woese CR, Dugre DH, Saxinger WC, Dugre SA: The Molecular Basis for the Genetic Code. Proceedings of the National Academy of Sciences 1966,55(4):966-974. 10.1073\u002Fpnas.55.4.966",{"doi":2590},"10.1073\u002Fpnas.55.4.966",{"id":26,"text":2592,"url":26,"identifiers":2593},"Ardell DH, Sella G: No accident: genetic codes freeze in error-correcting patterns of the standard genetic code. Philos Trans R Soc Lond B Biol Sci 2002,357(1427):1625-1642. 10.1098\u002Frstb.2002.1071",{"doi":2594},"10.1098\u002Frstb.2002.1071",{"id":26,"text":2596,"url":26,"identifiers":2597},"Woese CR: On the evolution of the genetic code. Proc Natl Acad Sci U S A 1965,54(6):1546-1552. 10.1073\u002Fpnas.54.6.1546",{"doi":2598},"10.1073\u002Fpnas.54.6.1546",{"id":26,"text":2600,"url":26,"identifiers":2601},"Chechetkin VR: Block structure and stability of the genetic code. J Theor Biol 2003,222(2):177-188. 10.1016\u002FS0022-5193(03)00025-0",{"doi":2602},"10.1016\u002FS0022-5193(03)00025-0",{"id":26,"text":2604,"url":26,"identifiers":2605},"Woese CR, Dugre DH, Dugre SA, Kondo M, Saxinger WC: On the fundamental nature and evolution of the genetic code. Cold Spring Harb Symp Quant Biol 1966, 31: 723-736.",{"doi":2606},"10.1101\u002FSQB.1966.031.01.093",{"id":26,"text":2608,"url":26,"identifiers":2609},"Alff-Steinberger C: The Genetic Code and Error Transmission. Proceedings of the National Academy of Sciences 1969,64(2):584-591. 10.1073\u002Fpnas.64.2.584",{"doi":2610},"10.1073\u002Fpnas.64.2.584",{"id":26,"text":2612,"url":26,"identifiers":2613},"Haig D, Hurst LD: A quantitative measure of error minimization in the genetic code. Journal of Molecular Evolution 1991,33(5):412-417. 10.1007\u002FBF02103132",{"doi":2614},"10.1007\u002FBF02103132",{"id":26,"text":2616,"url":26,"identifiers":2617},"Goldman N: Further results on error minimization in the genetic code. Journal of Molecular Evolution 1993,37(6):662-664.",{},{"id":26,"text":2619,"url":26,"identifiers":2620},"Freeland SJ, Wu T, Keulmann N: The case for an error minimizing standard genetic code. Orig Life Evol Biosph 2003,33(4-5):457-477. 10.1023\u002FA:1025771327614",{"doi":2621},"10.1023\u002FA:1025771327614",{"id":26,"text":2623,"url":26,"identifiers":2624},"Sella G, Ardell DH: The coevolution of genes and genetic codes: Crick's frozen accident revisited. J Mol Evol 2006,63(3):297-313. 10.1007\u002Fs00239-004-0176-7",{"doi":2625},"10.1007\u002Fs00239-004-0176-7",{"id":26,"text":2627,"url":26,"identifiers":2628},"Davies J, Gilbert W, Gorini L: Streptomycin, Suppression, and the Code. Proceedings of the National Academy of Sciences 1964,51(5):883-890. 10.1073\u002Fpnas.51.5.883",{"doi":2629},"10.1073\u002Fpnas.51.5.883",{"id":26,"text":2631,"url":26,"identifiers":2632},"Friedman SM, Weinstein IB: Lack of fidelity in the translation of ribopolynucleotides. Proc Natl Acad Sci USA 1964, 52: 988-996. 10.1073\u002Fpnas.52.4.988",{"doi":2633},"10.1073\u002Fpnas.52.4.988",{"id":26,"text":2635,"url":26,"identifiers":2636},"Parker J: Errors and alternatives in reading the universal genetic code. Microbiology and Molecular Biology Reviews 1989,53(3):273-298.",{},{"id":26,"text":2638,"url":26,"identifiers":2639},"Ardell DH, Sella G: On the evolution of redundancy in genetic codes. J Mol Evol 2001,53(4-5):269-281. 10.1007\u002Fs002390010217",{"doi":2640},"10.1007\u002Fs002390010217",{"id":26,"text":2642,"url":26,"identifiers":2643},"Sella G, Ardell DH: The impact of message mutation on the fitness of a genetic code. J Mol Evol 2002,54(5):638-651. 10.1007\u002Fs00239-001-0060-7",{"doi":2644},"10.1007\u002Fs00239-001-0060-7",{"id":26,"text":2646,"url":26,"identifiers":2647},"Freeland SJ, Knight RD, Landweber LF, Hurst LD: Early Fixation of an Optimal Genetic Code. Molecular Biology and Evolution 2000, 17: 511-518.",{"doi":2648},"10.1093\u002Foxfordjournals.molbev.a026331",{"id":26,"text":2650,"url":26,"identifiers":2651},"Gilis D, Massar S, Cerf NJ, Rooman M: Optimality of the genetic code with respect to protein stability and amino-acid frequencies. Genome Biol 2001,2(11):49.1–49.12. 10.1186\u002Fgb-2001-2-11-research0049",{"doi":2652},"10.1186\u002Fgb-2001-2-11-research0049",{"id":26,"text":2654,"url":26,"identifiers":2655},"Goodarzi H, Nejad HA, Torabi N: On the optimality of the genetic code, with the consideration of termination codons. Biosystems 2004,77(1-3):163-173. 10.1016\u002Fj.biosystems.2004.05.031",{"doi":2656},"10.1016\u002Fj.biosystems.2004.05.031",{"id":26,"text":2658,"url":26,"identifiers":2659},"Freeland SJ, Hurst LD: The Genetic Code Is One in a Million. Journal of Molecular Evolution 1998,47(3):238-248. 10.1007\u002FPL00006381",{"doi":2660},"10.1007\u002FPL00006381",{"id":26,"text":2662,"url":26,"identifiers":2663},"Gamow G: Possible relation between deoxyribonucleic acid and protein structures. Nature 1954, 173: 318. 10.1038\u002F173318a0",{"doi":2664},"10.1038\u002F173318a0",{"id":26,"text":2666,"url":26,"identifiers":2667},"Pelc SR: Correlation between coding-triplets and amino acids. Nature 1965,207(4997):597-599. 10.1038\u002F207597a0",{"doi":2668},"10.1038\u002F207597a0",{"id":26,"text":2670,"url":26,"identifiers":2671},"Yarus M: Amino Acids as RNA Ligands: A Direct-RNA-Template Theory for the Code's Origin. Journal of Molecular Evolution 1998,47(1):109-117. 10.1007\u002FPL00006357",{"doi":2672},"10.1007\u002FPL00006357",{"id":26,"text":2674,"url":26,"identifiers":2675},"Yarus M: A specific amino acid binding site composed of RNA. Science 1988,240(4860):1751. 10.1126\u002Fscience.3381099",{"doi":2676},"10.1126\u002Fscience.3381099",{"id":26,"text":2678,"url":26,"identifiers":2679},"Di Giulio M: The origin of the genetic code: theories and their relationships, a review. Biosystems 2005,80(2):175-184. 10.1016\u002Fj.biosystems.2004.11.005",{"doi":2680},"10.1016\u002Fj.biosystems.2004.11.005",{"id":26,"text":2682,"url":26,"identifiers":2683},"Knight RD, Freeland SJ, Landweber LF: Selection, history and chemistry: the three faces of the genetic code. J Biol Chem 1999, 273: 23019-23025.",{},{"id":26,"text":2685,"url":26,"identifiers":2686},"Yarus M: RNA–ligand chemistry: A testable source for the genetic code. RNA 2000,6(04):475-484. 10.1017\u002FS1355838200002569",{"doi":2687},"10.1017\u002FS1355838200002569",{"id":26,"text":2689,"url":26,"identifiers":2690},"Yarus M, Caporaso JG, Knight R: Origins of the genetic code: the escaped triplet theory. Annu Rev Biochem 2005, 74: 179-198. 10.1146\u002Fannurev.biochem.74.082803.133119",{"doi":2691},"10.1146\u002Fannurev.biochem.74.082803.133119",{"id":26,"text":2693,"url":26,"identifiers":2694},"Wolf YI, Koonin EV: On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization. Biol Direct 2007, 2: 14. 10.1186\u002F1745-6150-2-14",{"doi":2695},"10.1186\u002F1745-6150-2-14",{"id":26,"text":2697,"url":26,"identifiers":2698},"Wong JTF: A Co-Evolution Theory of the Genetic Code. Proceedings of the National Academy of Sciences 1975,72(5):1909-1912. 10.1073\u002Fpnas.72.5.1909",{"doi":2699},"10.1073\u002Fpnas.72.5.1909",{"id":26,"text":2701,"url":26,"identifiers":2702},"Wong JTF: Role of Minimization of Chemical Distances between Amino Acids in the Evolution of the Genetic Code. Proceedings of the National Academy of Sciences 1980,77(2):1083-1086. 10.1073\u002Fpnas.77.2.1083",{"doi":2703},"10.1073\u002Fpnas.77.2.1083",{"id":26,"text":2705,"url":26,"identifiers":2706},"Di Giulio M: The coevolution theory of the origin of the genetic code. Physics of Life Reviews 2004,1(2):128-137. 10.1016\u002Fj.plrev.2004.05.001",{"doi":2707},"10.1016\u002Fj.plrev.2004.05.001",{"id":26,"text":2709,"url":26,"identifiers":2710},"Di Giulio M: The Historical Factor: The Biosynthetic Relationships Between Amino Acids and Their Physicochemical Properties in the Origin of the Genetic Code. Journal of Molecular Evolution 1998,46(6):615-621. 10.1007\u002FPL00006341",{"doi":2711},"10.1007\u002FPL00006341",{"id":26,"text":2713,"url":26,"identifiers":2714},"Di Giulio M: Genetic Code Origin and the Strength of Natural Selection. Journal of Theoretical Biology 2000,205(4):659-661. 10.1006\u002Fjtbi.2000.2115",{"doi":2715},"10.1006\u002Fjtbi.2000.2115",{"id":26,"text":2717,"url":26,"identifiers":2718},"Freeland SJ, Hurst LD: Load minimization of the genetic code: history does not explain the pattern. Proceedings of the Royal Society B: Biological Sciences 1998,265(1410):2111-2119. 10.1098\u002Frspb.1998.0547",{"doi":2719},"10.1098\u002Frspb.1998.0547",{"id":26,"text":2721,"url":26,"identifiers":2722},"Di Giulio M: The origin of the genetic code. Trends in Biochemical Sciences 2000,25(2):44. 10.1016\u002FS0968-0004(99)01522-4",{"doi":2723},"10.1016\u002FS0968-0004(99)01522-4",{"id":26,"text":2725,"url":26,"identifiers":2726},"Freeland SJ, Knight RD, Landweber LF: Measuring adaptation within the genetic code. Trends Biochem Sci 2000,25(2):44-45. 10.1016\u002FS0968-0004(99)01531-5",{"doi":2727},"10.1016\u002FS0968-0004(99)01531-5",{"id":26,"text":2729,"url":26,"identifiers":2730},"Di Giulio M, Capobianco MR, Medugno M: On the optimization of the physicochemical distances between amino acids in the evolution of the genetic code. J Theor Biol 1994,168(1):43-51. 10.1006\u002Fjtbi.1994.1086",{"doi":2731},"10.1006\u002Fjtbi.1994.1086",{"id":26,"text":2733,"url":26,"identifiers":2734},"Kramer EB, Farabaugh PJ: The frequency of translational misreading errors in E. coli is largely determined by tRNA competition. Rna 2007,13(1):87-96. 10.1261\u002Frna.294907",{"doi":2735},"10.1261\u002Frna.294907",{"id":26,"text":2737,"url":26,"identifiers":2738},"Archetti M: Codon Usage Bias and Mutation Constraints Reduce the Level of ErrorMinimization of the Genetic Code. Journal of Molecular Evolution 2004,59(2):258-266. 10.1007\u002Fs00239-004-2620-0",{"doi":2739},"10.1007\u002Fs00239-004-2620-0",{"id":26,"text":2741,"url":26,"identifiers":2742},"Zhu CT, Zeng XB, Huang WD: Codon Usage Decreases the Error Minimization Within the Genetic Code. Journal of Molecular Evolution 2003,57(5):533-537. 10.1007\u002Fs00239-003-2505-7",{"doi":2743},"10.1007\u002Fs00239-003-2505-7",{"id":26,"text":2745,"url":26,"identifiers":2746},"Ardell DH: On error minimization in a sequential origin of the standard genetic code. J Mol Evol 1998,47(1):1-13. 10.1007\u002FPL00006356",{"doi":2747},"10.1007\u002FPL00006356",{"id":26,"text":2749,"url":26,"identifiers":2750},"Benner SA, Cohen MA, Gonnet GH: Amino acid substitution during functionally constrained divergent evolution of protein sequences. Protein Engineering 1994, 7: 1323-1332. 10.1093\u002Fprotein\u002F7.11.1323",{"doi":2751},"10.1093\u002Fprotein\u002F7.11.1323",{"id":26,"text":2753,"url":26,"identifiers":2754},"Di Giulio M: The Origin of the Genetic Code cannot be Studied using Measurements based on the PAM Matrix because this Matrix Reflects the Code Itself, Making any such Analyses Tautologous. Journal of Theoretical Biology 2001,208(2):141-144. 10.1006\u002Fjtbi.2000.2206",{"doi":2755},"10.1006\u002Fjtbi.2000.2206",{"id":26,"text":2757,"url":26,"identifiers":2758},"Ogle JM, Ramakrishnan V: Structural insights into translational fidelity. Annu Rev Biochem 2005, 74: 129-177. 10.1146\u002Fannurev.biochem.74.061903.155440",{"doi":2759},"10.1146\u002Fannurev.biochem.74.061903.155440",{"id":26,"text":2761,"url":26,"identifiers":2762},"Ogle JM, Carter AP, Ramakrishnan V: Insights into the decoding mechanism from recent ribosome structures. Trends Biochem Sci 2003,28(5):259-266. 10.1016\u002FS0968-0004(03)00066-5",{"doi":2763},"10.1016\u002FS0968-0004(03)00066-5",{"id":26,"text":2765,"url":26,"identifiers":2766},"Ogle JM, Brodersen DE, Clemons WM Jr., Tarry MJ, Carter AP, Ramakrishnan V: Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science 2001,292(5518):897-902. 10.1126\u002Fscience.1060612",{"doi":2767},"10.1126\u002Fscience.1060612",{"id":26,"text":2769,"url":26,"identifiers":2770},"Caporaso JG, Yarus M, Knight R: Error minimization and coding triplet\u002Fbinding site associations are independent features of the canonical genetic code. J Mol Evol 2005,61(5):597-607. 10.1007\u002Fs00239-004-0314-2",{"doi":2771},"10.1007\u002Fs00239-004-0314-2",{"id":26,"text":2773,"url":26,"identifiers":2774},"Goodarzi H, Shateri Najafabadi H, Torabi N: On the coevolution of genes and genetic code. Gene 2005, 362: 133-140. 10.1016\u002Fj.gene.2005.08.005",{"doi":2775},"10.1016\u002Fj.gene.2005.08.005",{"id":26,"text":2777,"url":26,"identifiers":2778},"Hasegawa M, Miyata T: On the antisymmetry of the amino acid code table. Origins of Life and Evolution of Biospheres (Formerly Origins of Life and Evolution of the Biosphere) 1980,10(3):265-270.",{},{"id":26,"text":2780,"url":26,"identifiers":2781},"King JL, Jukes TH: Non-Darwinian Evolution. Science 1969,164(3881):788-798. 10.1126\u002Fscience.164.3881.788",{"doi":2782},"10.1126\u002Fscience.164.3881.788",{"id":26,"text":2784,"url":26,"identifiers":2785},"Marquez R, Smit S, Knight R: Do universal codon-usage patterns minimize the effects of mutation and translation error? Genome Biol 2005,6(11):R91. 10.1186\u002Fgb-2005-6-11-r91",{"doi":2786},"10.1186\u002Fgb-2005-6-11-r91",{"id":26,"text":2788,"url":26,"identifiers":2789},"Goodarzi H, Najafabadi HS, Hassani K, Nejad HA, Torabi N: On the optimality of the genetic code, with the consideration of coevolution theory by comparison of prominent cost measure matrices. J Theor Biol 2005,235(3):318-325. 10.1016\u002Fj.jtbi.2005.01.012",{"doi":2790},"10.1016\u002Fj.jtbi.2005.01.012",{"id":26,"text":2792,"url":26,"identifiers":2793},"Jukes TH: Arginine as an evolutionary intruder into protein synthesis. Biochem Biophys Res Commun 1973,53(3):709-714. 10.1016\u002F0006-291X(73)90151-4",{"doi":2794},"10.1016\u002F0006-291X(73)90151-4",{"id":26,"text":2796,"url":26,"identifiers":2797},"Tolstrup N, Toftgard J, Engelbrecht J, Brunak S: Neural network model of the genetic code is strongly correlated to the GES scale of amino acid transfer free energies. J Mol Biol 1994,243(5):816-820. 10.1006\u002Fjmbi.1994.1683",{"doi":2798},"10.1006\u002Fjmbi.1994.1683",{"id":26,"text":2800,"url":26,"identifiers":2801},"Swanson R: A unifying concept for the amino acid code. Bulletin of Mathematical Biology 1984,46(2):187-203.",{"doi":2802},"10.1007\u002FBF02460068",{"id":26,"text":2804,"url":26,"identifiers":2805},"Jukes TH: Possibilities for the evolution of the genetic code from a preceding form. Nature 1973,246(5427):22-26. 10.1038\u002F246022a0",{"doi":2806},"10.1038\u002F246022a0",{"id":2808,"createTime":2809,"updateTime":2810,"relativeEntities":2811,"slug":2812,"properties":2813,"entityType":846,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":2832,"translateLanguages":2833,"viewCount":36,"primaryUrl":2834,"fullTextUrl":26,"authors":2835,"publicationType":912,"publisherRelationship":2922,"citationCount":2562,"citationInfo":2950,"publishDate":2565,"publishYear":2566,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2952,"isForceReanalyzing":948},"6bbd99aa-357e-4d71-baac-71566d21a3a8","2024-04-16T04:02:03.486+00:00","2025-01-05T12:39:32.490+00:00",[],"Natural-variation-in-SAR11-marine-bacterioplankton-genomes-inferred-from-metagenomic-data",{"mag":2814,"keywords":2816,"pmc":2818,"openalex":2820,"abstract":2822,"title":2825,"pm":2828,"doi":2830},{"VOID":2815},"2151964296",{"VI":2817},"SAR11, siêu gen học, vi khuẩn phù sa biển, phân tích gen, biến đổi gen.",{"VOID":2819},"2217521",{"VOID":2821},"W2151964296",{"VI":2823,"EN":2824},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Nền tảng\u003C\u002Fjats:title>\n            \u003Cjats:p> Một trong những mục tiêu của siêu gen học là tái cấu trúc thông tin về các sinh vật không thể nuôi cấy cụ thể từ các trình tự DNA môi trường phân mảnh. Chúng tôi đã sử dụng bộ gen của một chủng vi khuẩn alpha-proteobacteria biển SAR11 ('\u003Cjats:italic>Candidatus\u003C\u002Fjats:italic> Pelagibacter ubique'; chủng HTCC1062), thu được từ bờ biển Oregon lạnh và năng suất cao, làm trình tự truy vấn để nghiên cứu sự biến đổi trong dữ liệu trình tự siêu gen SAR11 từ Biển Sargasso, một vòng xoáy đại dương ấm, nghèo dinh dưỡng.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p> Độ đồng nhất trung bình của các axit amin của gen SAR11 được mã hóa bởi dữ liệu siêu gen với bộ gen truy vấn chỉ đạt 71%, điều này cho thấy sự phân kỳ tiến hóa đáng kể giữa các chủng ven biển và dân số ở Biển Sargasso. Tuy nhiên, một phân tích các láng giềng gen cho thấy gen SAR11 trong dữ liệu siêu gen của Biển Sargasso phù hợp với thứ tự gen của bộ gen HTCC1062 trong 96% trường hợp (> 85.000 quan sát), và rằng sự thay đổi thứ tự xảy ra thường xuyên nhất tại các ranh giới operon dự đoán. Không có ví dụ bảo tồn nào của các gen có chức năng đã biết được tìm thấy ở các chủng ven biển, nhưng không có trong dữ liệu siêu gen Biển Sargasso, hoặc ngược lại, điều này gợi ý rằng các vùng lõi của các bộ gen SAR11 đa dạng này tương đối bảo tồn về nội dung gen. Tuy nhiên, bốn vùng biến đổi cao đã được quan sát, có thể mã hóa các đặc tính liên quan đến sự biến đổi trong các kiểu hình SAR11. Vùng lớn nhất trong số này, HVR2, là một vùng 48 kb được bao quanh bởi các gen 5S và 23S duy nhất trong bộ gen HTCC1062, và chủ yếu mã hóa các gen xác định các đặc tính bề mặt tế bào. Một so sánh giữa hai bộ gen '\u003Cjats:italic>Candidatus\u003C\u002Fjats:italic> Pelagibacter' có liên quan chặt chẽ (HTCC1062 và HTCC1002) đã tiết lộ một số \"gene indels\" trong các vùng lõi. Hầu hết trong số này được tìm thấy là đa hình trong dữ liệu siêu gen và có bằng chứng của sự chọn lọc tinh khiết, gợi ý rằng cùng một \"gene indels đa hình\" được duy trì trong các quần thể SAR11 bị cô lập về mặt vật lý.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>One objective of metagenomics is to reconstruct information about specific uncultured organisms from fragmentary environmental DNA sequences. We used the genome of an isolate of the marine alphaproteobacterium SAR11 ('\u003Cjats:italic>Candidatus\u003C\u002Fjats:italic> Pelagibacter ubique'; strain HTCC1062), obtained from the cold, productive Oregon coast, as a query sequence to study variation in SAR11 metagenome sequence data from the Sargasso Sea, a warm, oligotrophic ocean gyre.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>The average amino acid identity of SAR11 genes encoded by the metagenomic data to the query genome was only 71%, indicating significant evolutionary divergence between the coastal isolates and Sargasso Sea populations. However, an analysis of gene neighbors indicated that SAR11 genes in the Sargasso Sea metagenomic data match the gene order of the HTCC1062 genome in 96% of cases (> 85,000 observations), and that rearrangements are most frequent at predicted operon boundaries. There were no conserved examples of genes with known functions being found in the coastal isolates, but not the Sargasso Sea metagenomic data, or vice versa, suggesting that core regions of these diverse SAR11 genomes are relatively conserved in gene content. However, four hypervariable regions were observed, which may encode properties associated with variation in SAR11 ecotypes. The largest of these, HVR2, is a 48 kb region flanked by the sole 5S and 23S genes in the HTCC1062 genome, and mainly encodes genes that determine cell surface properties. A comparison of two closely related '\u003Cjats:italic>Candidatus\u003C\u002Fjats:italic> Pelagibacter' genomes (HTCC1062 and HTCC1002) revealed a number of \"gene indels\" in core regions. Most of these were found to be polymorphic in the metagenomic data and showed evidence of purifying selection, suggesting that the same \"polymorphic gene indels\" are maintained in physically isolated SAR11 populations.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>These findings suggest that natural selection has conserved many core features of SAR11 genomes across broad oceanic scales, but significant variation was found associated with four hypervariable genome regions. The data also led to the hypothesis that some gene insertions and deletions might be polymorphisms, similar to allelic polymorphisms.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":2826,"EN":2827},"Biến thể tự nhiên trong bộ gen vi khuẩn phù sa biển SAR11 được suy luận từ dữ liệu siêu gen","Natural variation in SAR11 marine bacterioplankton genomes inferred from metagenomic data",{"VOID":2829},"17988398",{"VOID":2831},"10.1186\u002F1745-6150-2-27",[102],[101],"https:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-2-27",[2836,2855,2876,2892,2906],{"id":2837,"sortIndex":114,"researcher":26,"roles":2838,"affiliations":2839,"properties":2848},"1c9bb271-ba7c-404f-8400-9ed249ec3c6a",[],[2840],{"id":26,"sortIndex":36,"affiliation":2841,"properties":26},{"id":2842,"createTime":2843,"updateTime":2843,"relativeEntities":2844,"slug":26,"properties":2845,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"66de2603-3b6d-4cd3-9710-5b221637288b","2024-01-01T17:30:17.278+00:00",[],{"title":2846},{"VI":2847},"Center for Genome Research and Bioinformatics, Oregon State University, Corvallis, OR 97331, USA",{"openalex":2849,"orcid":2851,"title":2853},{"VOID":2850},"A5040355364",{"VOID":2852},"https:\u002F\u002Forcid.org\u002F0000-0002-0630-8589",{"EN":2854},"Scott A. Givan",{"id":2856,"sortIndex":59,"researcher":26,"roles":2857,"affiliations":2858,"properties":2869},"416a0fcb-13ab-4dec-93b3-bbd12c5afccb",[],[2859],{"id":26,"sortIndex":36,"affiliation":2860,"properties":26},{"id":2861,"createTime":2862,"updateTime":2863,"relativeEntities":2864,"slug":2865,"properties":2866,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"4f9c4e6a-2d0a-481c-8b74-4a5541680692","2023-12-08T09:42:00.565+00:00","2024-10-11T10:34:53.220+00:00",[],"Department-of-Microbiology-Oregon-State-University-Corvallis-OR-97331-USA",{"title":2867},{"VI":2868},"Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA",{"openalex":2870,"orcid":2872,"title":2874},{"VOID":2871},"A5034511241",{"VOID":2873},"https:\u002F\u002Forcid.org\u002F0000-0002-2479-2044",{"EN":2875},"Daniel P. Smith",{"id":2877,"sortIndex":36,"researcher":26,"roles":2878,"affiliations":2879,"properties":2885},"1880bee5-6adf-4623-85ec-a08db5f67647",[],[2880],{"id":26,"sortIndex":36,"affiliation":2881,"properties":26},{"id":2861,"createTime":2862,"updateTime":2863,"relativeEntities":2882,"slug":2865,"properties":2883,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2884},{"VI":2868},{"openalex":2886,"orcid":2888,"title":2890},{"VOID":2887},"A5070129165",{"VOID":2889},"https:\u002F\u002Forcid.org\u002F0009-0005-7273-1034",{"EN":2891},"Larry J. Wilhelm",{"id":2893,"sortIndex":115,"researcher":26,"roles":2894,"affiliations":2895,"properties":2901},"d2449a06-7aec-4dca-b895-9dcc305d8a8d",[],[2896],{"id":26,"sortIndex":36,"affiliation":2897,"properties":26},{"id":2861,"createTime":2862,"updateTime":2863,"relativeEntities":2898,"slug":2865,"properties":2899,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2900},{"VI":2868},{"openalex":2902,"title":2904},{"VOID":2903},"A5003441012",{"EN":2905},"H. James Tripp",{"id":2907,"sortIndex":111,"researcher":26,"roles":2908,"affiliations":2909,"properties":2915},"6bdc63fe-83d9-485d-bbfc-c1d9e4ef7dbc",[],[2910],{"id":26,"sortIndex":36,"affiliation":2911,"properties":26},{"id":2861,"createTime":2862,"updateTime":2863,"relativeEntities":2912,"slug":2865,"properties":2913,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2914},{"VI":2868},{"openalex":2916,"orcid":2918,"title":2920},{"VOID":2917},"A5022298420",{"VOID":2919},"https:\u002F\u002Forcid.org\u002F0000-0002-2431-4296",{"EN":2921},"Stephen J. Giovannoni",{"url":26,"publisher":2923,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2924,"slug":663,"properties":2925,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2928,"manageAffiliations":2929,"indexDatabases":2930,"url":26,"thumbnailPath":26,"statistic":2945,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":2926,"title":2927},{"VOID":666},{"EN":668},[],[],[2931,2938],{"id":764,"indexDatabase":2932,"url":779,"indexYears":26,"academicFieldIds":2937,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":2933,"label":2934,"description":2935,"key":775,"publicationTags":2936,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":2939,"url":753,"indexYears":754,"academicFieldIds":2944,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":2940,"label":2941,"description":2942,"key":750,"publicationTags":2943,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":2946,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":2947,"totalCitation":793,"totalCitationByYear":2948,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":2949,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"total":2562,"publishYear":26,"statisticByYear":2951},{"2012":53,"2013":116,"2014":103,"2015":59,"2016":158,"2017":59,"2018":162,"2019":114,"2020":59,"2022":111,"2023":114},[2953,2957,2961,2965,2969,2973,2977,2981,2985,2989,2993,2997,3001,3005,3009,3012,3016,3020,3024,3028,3032,3036,3040,3044,3048,3052,3056,3060,3064,3068,3072,3076,3080,3084,3088,3092,3096,3099,3103,3107,3111,3114,3118,3122,3126,3130,3133,3137,3141],{"id":26,"text":2954,"url":26,"identifiers":2955},"Welch RA, Burland V, Plunkett G 3rd, Redford P, Roesch P, Rasko D, Buckles EL, Liou SR, Boutin A, Hackett J, et al.: Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. Proc Natl Acad Sci USA 2002, 99: 17020-17024. 10.1073\u002Fpnas.252529799",{"doi":2956},"10.1073\u002Fpnas.252529799",{"id":26,"text":2958,"url":26,"identifiers":2959},"Thompson JR, Pacocha S, Pharino C, Klepac-Ceraj V, Hunt DE, Benoit J, Sarma-Rupavtarm R, Distel DL, Polz MF: Genotypic diversity within a natural coastal bacterioplankton population. Science 2005, 307: 1311-1313. 10.1126\u002Fscience.1106028",{"doi":2960},"10.1126\u002Fscience.1106028",{"id":26,"text":2962,"url":26,"identifiers":2963},"Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, et al.: Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial \"pan-genome\". Proc Natl Acad Sci USA 2005, 102: 13950-13955. 10.1073\u002Fpnas.0506758102",{"doi":2964},"10.1073\u002Fpnas.0506758102",{"id":26,"text":2966,"url":26,"identifiers":2967},"Konstantinidis KT, Tiedje JM: Genomic insights that advance the species definition for prokaryotes. Proc Natl Acad Sci USA 2005, 102: 2567-2572. 10.1073\u002Fpnas.0409727102",{"doi":2968},"10.1073\u002Fpnas.0409727102",{"id":26,"text":2970,"url":26,"identifiers":2971},"Tyson GW, Chapman J, Hugenholtz P, Allen EE, Ram RJ, Richardson PM, Solovyev VV, Rubin EM, Rokhsar DS, Banfield JF: Community structure and metabolism through reconstruction of microbial genomes from the environment. Nature 2004, 428: 37-43. 10.1038\u002Fnature02340",{"doi":2972},"10.1038\u002Fnature02340",{"id":26,"text":2974,"url":26,"identifiers":2975},"Steinberg DK, Carlson CA, Bates NR, Johnson RH, Michaels AF, Knap AH: Overview of the US JGOFS Bermuda Atlantic Time-series Study (BATS): a decade-scale look at ocean biology and biochemistry. Deep-Sea Research II 2001, 48: 1405-1447. 10.1016\u002FS0967-0645(00)00148-X",{"doi":2976},"10.1016\u002FS0967-0645(00)00148-X",{"id":26,"text":2978,"url":26,"identifiers":2979},"Venter JC, Remington K, Heidelberg JF, Halpern AL, Rusch D, Eisen JA, Wu D, Paulsen I, Nelson KE, Nelson W, et al.: Environmental genome shotgun sequencing of the Sargasso Sea. Science 2004, 304: 66-74. 10.1126\u002Fscience.1093857",{"doi":2980},"10.1126\u002Fscience.1093857",{"id":26,"text":2982,"url":26,"identifiers":2983},"Dufresne A, Garczarek L, Partensky F: Accelerated evolution associated with genome reduction in a free-living prokaryote. Genome Biology 2005, 6: R14. 10.1186\u002Fgb-2005-6-2-r14",{"doi":2984},"10.1186\u002Fgb-2005-6-2-r14",{"id":26,"text":2986,"url":26,"identifiers":2987},"Giovannoni SJ, Tripp HJ, Givan S, Podar M, Vergin K, Batista D, Bibbs L, Eads J, Richardson TH, Noordewier M, et al.: Genome streamlining in a cosmopolitan oceanic bacterium. Science 2005, 309: 1242-1245. 10.1126\u002Fscience.1114057",{"doi":2988},"10.1126\u002Fscience.1114057",{"id":26,"text":2990,"url":26,"identifiers":2991},"Rappé MS, Giovannoni SJ: The uncultured microbial majority. Annual Reviews Microbiology 2003, 57: 369-394. 10.1146\u002Fannurev.micro.57.030502.090759",{"doi":2992},"10.1146\u002Fannurev.micro.57.030502.090759",{"id":26,"text":2994,"url":26,"identifiers":2995},"Morris RM, Cho JC, Rappe MS, Vergin KL, Carlson CA, Giovannoni SJ: Temporal and spatial response of bacterioplankton lineages to annual convective overturn at the Bermuda Atlantic Time-series Study site. Limnol Oceanography 2005, 50: 1687-1696.",{"doi":2996},"10.4319\u002Flo.2005.50.5.1687",{"id":26,"text":2998,"url":26,"identifiers":2999},"Giovannoni SJ, Stingl U: Molecular Diversity and Ecology of Microbial Plankton. Nature Insight 2005, 437: 343-348.",{"doi":3000},"10.1038\u002Fnature04158",{"id":26,"text":3002,"url":26,"identifiers":3003},"Rusch DB, Halpern AL, Sutton G, Heidelberg KB, Williamson S, Yooseph S, Wu D, Eisen JA, Hoffman JM, Remington K, et al.: The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific. PLoS Biol 2007, 5: e77. 10.1371\u002Fjournal.pbio.0050077",{"doi":3004},"10.1371\u002Fjournal.pbio.0050077",{"id":26,"text":3006,"url":26,"identifiers":3007},"Rappé MS, Connon SA, Vergin KL, Giovannoni SJ: Cultivation of the ubiquitous SAR11 marine bacterioplankton clade. Nature 2002, 418: 630-633. 10.1038\u002Fnature00917",{"doi":3008},"10.1038\u002Fnature00917",{"id":26,"text":3010,"url":26,"identifiers":3011},"Smith RL, Huyer A, Fleischbein J: The coastal ocean off Oregon from 1961 to 2000: is there evidence of climate change or only of Los Niños? Progress in Oceanography 2001, 53: 369-387.",{},{"id":26,"text":3013,"url":26,"identifiers":3014},"Brown MV, Schwalbach MS, Hewson I, Fuhrman JA: Coupling 16S-ITS rDNA clone libraries and automated ribosomal intergenic spacer analysis to show marine microbial diversity: development and application to a time series. Environ Microbiol 2005, 7: 1466-1479. 10.1111\u002Fj.1462-2920.2005.00835.x",{"doi":3015},"10.1111\u002Fj.1462-2920.2005.00835.x",{"id":26,"text":3017,"url":26,"identifiers":3018},"Hallam SJ, Konstantinidis KT, Putnam N, Schleper C, Watanabe Y, Sugahara J, Preston C, de la Torre J, Richardson PM, DeLong EF: Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum. Proc Natl Acad Sci USA 2006, 103: 18296-18301. 10.1073\u002Fpnas.0608549103",{"doi":3019},"10.1073\u002Fpnas.0608549103",{"id":26,"text":3021,"url":26,"identifiers":3022},"Rasko DA, Myers GS, Ravel J: Visualization of comparative genomic analyses by BLAST score ratio. BMC Bioinformatics 2005, 6: 2. 10.1186\u002F1471-2105-6-2",{"doi":3023},"10.1186\u002F1471-2105-6-2",{"id":26,"text":3025,"url":26,"identifiers":3026},"Coleman ML, Sullivan MB, Martiny AC, Steglich C, Barry K, Delong EF, Chisholm SW: Genomic islands and the ecology and evolution of Prochlorococcus. Science 2006, 311: 1768-1770. 10.1126\u002Fscience.1122050",{"doi":3027},"10.1126\u002Fscience.1122050",{"id":26,"text":3029,"url":26,"identifiers":3030},"DeLong EF: Microbial community genomics in the ocean. Nat Rev Microbiol 2005, 3: 459-469. 10.1038\u002Fnrmicro1158",{"doi":3031},"10.1038\u002Fnrmicro1158",{"id":26,"text":3033,"url":26,"identifiers":3034},"Price MN, Huang KH, Alm EJ, Arkin AP: A novel method for accurate operon predictions in all sequenced prokaryotes. Nucleic Acids Res 2005, 33: 880-892. 10.1093\u002Fnar\u002Fgki232",{"doi":3035},"10.1093\u002Fnar\u002Fgki232",{"id":26,"text":3037,"url":26,"identifiers":3038},"Béjà O, Aravind L, Koonin EV, Suzuki M, Hadd A, Nguyen LP, Jovanovich SB, Gates CM, Feldman RA, Spudich JL, et al.: Bacterial rhodopsin: evidence for a new type of phototrophy in the sea. Science 2000, 289: 1902-1906. 10.1126\u002Fscience.289.5486.1902",{"doi":3039},"10.1126\u002Fscience.289.5486.1902",{"id":26,"text":3041,"url":26,"identifiers":3042},"Giovannoni SJ, Bibbs L, Cho JC, Stapels MD, Desiderio R, Vergin KL, Rappe MS, Laney S, Wilhelm LJ, Tripp HJ, et al.: Proteorhodopsin in the ubiquitous marine bacterium SAR11. Nature 2005, 438: 82-85. 10.1038\u002Fnature04032",{"doi":3043},"10.1038\u002Fnature04032",{"id":26,"text":3045,"url":26,"identifiers":3046},"Dobrindt U, Hochhut B, Hentschel U, Hacker J: Genomic islands in pathogenic and environmental microorganisms. Nat Rev Microbiol 2004, 2: 414-424. 10.1038\u002Fnrmicro884",{"doi":3047},"10.1038\u002Fnrmicro884",{"id":26,"text":3049,"url":26,"identifiers":3050},"Hacker J, Carniel E: Ecological fitness, genomic islands and bacterial pathogenicity. A Darwinian view of the evolution of microbes. EMBO Rep 2001, 2: 376-381.",{"doi":3051},"10.1093\u002Fembo-reports\u002Fkve097",{"id":26,"text":3053,"url":26,"identifiers":3054},"Rocap G, Larimer FW, Lamerdin J, Malfatti S, Chain P, Ahlgren NA, Arellano A, Coleman M, Hauser L, Hess WR, et al.: Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation. Nature 2003, 424: 1042-1047. 10.1038\u002Fnature01947",{"doi":3055},"10.1038\u002Fnature01947",{"id":26,"text":3057,"url":26,"identifiers":3058},"Berg OG, Kurland CG: Evolution of microbial genomes: sequence acquisition and loss. Mol Biol Evol 2002, 19: 2265-2276.",{"doi":3059},"10.1093\u002Foxfordjournals.molbev.a004050",{"id":26,"text":3061,"url":26,"identifiers":3062},"Lerat E, Daubin V, Ochman H, Moran NA: Evolutionary origins of genomic repertoires in bacteria. PLoS Biol 2005, 3: e130. 10.1371\u002Fjournal.pbio.0030130",{"doi":3063},"10.1371\u002Fjournal.pbio.0030130",{"id":26,"text":3065,"url":26,"identifiers":3066},"Nilsson AI, Koskiniemi S, Eriksson S, Kugelberg E, Hinton JC, Andersson DI: Bacterial genome size reduction by experimental evolution. Proc Natl Acad Sci USA 2005, 102: 12112-12116. 10.1073\u002Fpnas.0503654102",{"doi":3067},"10.1073\u002Fpnas.0503654102",{"id":26,"text":3069,"url":26,"identifiers":3070},"Rozen DE, Schneider D, Lenski RE: Long-term experimental evolution in Escherichia coli. XIII. Phylogenetic history of a balanced polymorphism. J Mol Evol 2005, 61: 171-180. 10.1007\u002Fs00239-004-0322-2",{"doi":3071},"10.1007\u002Fs00239-004-0322-2",{"id":26,"text":3073,"url":26,"identifiers":3074},"Cohan FM: What are bacterial species? Annu Rev Microbiol 2002, 56: 457-487. 10.1146\u002Fannurev.micro.56.012302.160634",{"doi":3075},"10.1146\u002Fannurev.micro.56.012302.160634",{"id":26,"text":3077,"url":26,"identifiers":3078},"Tamames J: Evolution of gene order conservation in prokaryotes. Genome Biol 2001, 2: 11. 10.1186\u002Fgb-2001-2-6-research0020",{"doi":3079},"10.1186\u002Fgb-2001-2-6-research0020",{"id":26,"text":3081,"url":26,"identifiers":3082},"Wolf YI, Rogozin IB, Kondrashov AS, Koonin EV: Genome alignment, evolution of prokaryotic genome organization, and prediction of gene function using genomic context. Genome Res 2001, 11: 356-372. 10.1101\u002Fgr.GR-1619R",{"doi":3083},"10.1101\u002Fgr.GR-1619R",{"id":26,"text":3085,"url":26,"identifiers":3086},"Huynen MA, Bork P: Measuring genome evolution. Proc Natl Acad Sci USA 1998, 95: 5849-5856. 10.1073\u002Fpnas.95.11.5849",{"doi":3087},"10.1073\u002Fpnas.95.11.5849",{"id":26,"text":3089,"url":26,"identifiers":3090},"Linton D, Karlyshev AV, Wren BW: Deciphering Campylobacter jejuni cell surface interactions from the genome sequence. Curr Opin Microbiol 2001, 4: 35-40. 10.1016\u002FS1369-5274(00)00161-2",{"doi":3091},"10.1016\u002FS1369-5274(00)00161-2",{"id":26,"text":3093,"url":26,"identifiers":3094},"Proctor LM, Fuhrman JA: Viral mortality of marine bacteria and cyanobacteria. Nature 1990, 343: 60-62. 350 10.1038\u002F343060a0",{"doi":3095},"10.1038\u002F343060a0",{"id":26,"text":3097,"url":26,"identifiers":3098},"Vergin KL, Tripp HJ, Wilhelm LJ, Denver DR, Rappe MS, Giovannoni SJ: High Intraspecific Recombination Rate in a Native Population of Candidatus Pelagibacter ubique (SAR11). Environmental Microbiology 2007. Online Early: doi: 10.1111\u002Fj.1462-2920.2007.01361.x",{},{"id":26,"text":3100,"url":26,"identifiers":3101},"Bashford D, Chothia C, Lesk AM: Determinants of a protein fold. Unique features of the globin amino acid sequences. J Mol Biol 1987, 196: 199-216. 10.1016\u002F0022-2836(87)90521-3",{"doi":3102},"10.1016\u002F0022-2836(87)90521-3",{"id":26,"text":3104,"url":26,"identifiers":3105},"Thompson JD, Higgins DG, Gibson TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994, 22: 4673-4680. 10.1093\u002Fnar\u002F22.22.4673",{"doi":3106},"10.1093\u002Fnar\u002F22.22.4673",{"id":26,"text":3108,"url":26,"identifiers":3109},"Stamatakis A: RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Bioinformatics 2006, 22: 2688-2690. 10.1093\u002Fbioinformatics\u002Fbtl446",{"doi":3110},"10.1093\u002Fbioinformatics\u002Fbtl446",{"id":26,"text":3112,"url":26,"identifiers":3113},"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997, 25: 3389-3402. 10.1093\u002Fnar\u002F25.17.3389",{"doi":1930},{"id":26,"text":3115,"url":26,"identifiers":3116},"Rocap G, Distel DL, Waterbury JB, Chisholm SW: Resolution of Prochlorococcus and Synechococcus ecotypes by using 16S-23S ribosomal DNA internal transcribed spacer sequences. Appl Environ Microbiol 2002, 68: 1180-1191. 10.1128\u002FAEM.68.3.1180-1191.2002",{"doi":3117},"10.1128\u002FAEM.68.3.1180-1191.2002",{"id":26,"text":3119,"url":26,"identifiers":3120},"Holmes AJ, Gillings MR, Nield BS, Mabbutt BC, Nevalainen KM, Stokes HW: The gene cassette metagenome is a basic resource for bacterial genome evolution. Environ Microbiol 2003, 5: 383-394. 10.1046\u002Fj.1462-2920.2003.00429.x",{"doi":3121},"10.1046\u002Fj.1462-2920.2003.00429.x",{"id":26,"text":3123,"url":26,"identifiers":3124},"Reiter WD, Palm P, Yeats S: Transfer RNA genes frequently serve as integration sites for prokaryotic genetic elements. Nucleic Acids Res 1989, 17: 1907-1914. 10.1093\u002Fnar\u002F17.5.1907",{"doi":3125},"10.1093\u002Fnar\u002F17.5.1907",{"id":26,"text":3127,"url":26,"identifiers":3128},"Daubin V, Ochman H: Bacterial genomes as new gene homes: the genealogy of ORFans in E. coli. Genome Res 2004, 14: 1036-1042. 10.1101\u002Fgr.2231904",{"doi":3129},"10.1101\u002Fgr.2231904",{"id":26,"text":3131,"url":26,"identifiers":3132},"Pride DT: A tool for analyzing substitutions and similarity in multiple alignments. Distributed by the author 2005.",{},{"id":26,"text":3134,"url":26,"identifiers":3135},"Rozas J, Sanchez-DelBarrio JC, Messeguer X, Rozas R: DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics 2003, 19: 2496-2497. 10.1093\u002Fbioinformatics\u002Fbtg359",{"doi":3136},"10.1093\u002Fbioinformatics\u002Fbtg359",{"id":26,"text":3138,"url":26,"identifiers":3139},"Marchler-Bauer A, Anderson JB, Cherukuri PF, DeWeese-Scott C, Geer LY, Gwadz M, He S, Hurwitz DI, Jackson JD, Ke Z, et al.: CDD: a Conserved Domain Database for protein classification. Nucleic Acids Res 2005, (33 Database):D192-196.",{"doi":3140},"10.1093\u002Fnar\u002Fgki069",{"id":26,"text":3142,"url":26,"identifiers":3143},"Oregon State University Giovanonni laboratory[http:\u002F\u002Fwww.mcb.oregonstate.edu\u002Fgiovannoni\u002F]",{},{"id":3145,"createTime":3146,"updateTime":3147,"relativeEntities":3148,"slug":3149,"properties":3150,"entityType":846,"verifyStatus":25,"verifyTime":3165,"verifyNote":969,"syncStatus":28,"languages":3166,"translateLanguages":26,"viewCount":36,"primaryUrl":3167,"fullTextUrl":26,"authors":3168,"publicationType":912,"publisherRelationship":3209,"citationCount":3237,"citationInfo":3238,"publishDate":3240,"publishYear":1708,"citationAnalyzeStatus":946,"lastCitationAnalyze":3241,"indexDatabases":26,"openAccess":26,"references":3242,"isForceReanalyzing":948},"f0e7ffeb-848f-420c-94b5-22467869c5d8","2024-04-14T01:15:51.121+00:00","2025-01-03T14:56:46.394+00:00",[],"Cooperativity-within-proximal-phosphorylation-sites-is-revealed-from-large-scale-proteomics-data",{"mag":3151,"keywords":3153,"pmc":3154,"openalex":3156,"abstract":3158,"title":3159,"pm":3161,"doi":3163},{"VOID":3152},"2137198216",{},{"VOID":3155},"2828979",{"VOID":3157},"W2137198216",{},{"EN":3160},"Cooperativity within proximal phosphorylation sites is revealed from large-scale proteomics data",{"VOID":3162},"20100358",{"VOID":3164},"10.1186\u002F1745-6150-5-6","2025-01-03T14:56:46.393+00:00",[102],"http:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-5-6",[3169,3189],{"id":3170,"sortIndex":115,"researcher":26,"roles":3171,"affiliations":3172,"properties":3182},"7334c4aa-b25c-41c1-90cd-3ce75812683f",[],[3173],{"id":26,"sortIndex":36,"affiliation":3174,"properties":26},{"id":3175,"createTime":3176,"updateTime":3176,"relativeEntities":3177,"slug":3178,"properties":3179,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2a0b2fc6-4460-44ef-b999-5478bf3eb4b2","2024-04-14T01:15:51.144+00:00",[],"Department-of-Biological-Chemistry-Institute-of-Life-Sciences-Sudarsky-Center-for-Computational-Biology-Hebrew-University-of-Jerusalem-91904-Israel",{"title":3180},{"EN":3181},"Department of Biological Chemistry, Institute of Life Sciences, Sudarsky Center for Computational Biology, Hebrew University of Jerusalem, 91904, Israel",{"openalex":3183,"orcid":3185,"title":3187},{"VOID":3184},"A5085924022",{"VOID":3186},"https:\u002F\u002Forcid.org\u002F0000-0002-9357-4526",{"EN":3188},"Michal Linial",{"id":3190,"sortIndex":36,"researcher":26,"roles":3191,"affiliations":3192,"properties":3202},"b238cc25-f293-4875-9ad0-3e7704374593",[],[3193],{"id":26,"sortIndex":36,"affiliation":3194,"properties":26},{"id":3195,"createTime":3196,"updateTime":3196,"relativeEntities":3197,"slug":3198,"properties":3199,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e704949f-a3cf-4660-9d0c-81608076ba67","2024-04-14T01:15:51.130+00:00",[],"School-of-Computer-Science-and-Engineering-Hebrew-University-of-Jerusalem-91904-Israel",{"title":3200},{"EN":3201},"School of Computer Science and Engineering, Hebrew University of Jerusalem, 91904, Israel",{"openalex":3203,"orcid":3205,"title":3207},{"VOID":3204},"A5027186771",{"VOID":3206},"https:\u002F\u002Forcid.org\u002F0000-0003-2450-8901",{"EN":3208},"Regev Schweiger",{"url":26,"publisher":3210,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3211,"slug":663,"properties":3212,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3215,"manageAffiliations":3216,"indexDatabases":3217,"url":26,"thumbnailPath":26,"statistic":3232,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":3213,"title":3214},{"VOID":666},{"EN":668},[],[],[3218,3225],{"id":764,"indexDatabase":3219,"url":779,"indexYears":26,"academicFieldIds":3224,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":3220,"label":3221,"description":3222,"key":775,"publicationTags":3223,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":3226,"url":753,"indexYears":754,"academicFieldIds":3231,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":3227,"label":3228,"description":3229,"key":750,"publicationTags":3230,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":3233,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":3234,"totalCitation":793,"totalCitationByYear":3235,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":3236,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},98,{"total":3237,"publishYear":26,"statisticByYear":3239},{"2012":52,"2013":158,"2014":50,"2015":50,"2016":162,"2017":158,"2018":158,"2019":158,"2020":53,"2021":356,"2022":50,"2023":59},"2010-01-01","2024-04-14T12:33:44.744+00:00",[],{"id":3244,"createTime":3245,"updateTime":3246,"relativeEntities":3247,"slug":3248,"properties":3249,"entityType":846,"verifyStatus":25,"verifyTime":3246,"verifyNote":969,"syncStatus":28,"languages":3267,"translateLanguages":3268,"viewCount":36,"primaryUrl":3269,"fullTextUrl":26,"authors":3270,"publicationType":912,"publisherRelationship":3327,"citationCount":353,"citationInfo":3355,"publishDate":1396,"publishYear":1397,"citationAnalyzeStatus":946,"lastCitationAnalyze":3357,"indexDatabases":26,"openAccess":26,"references":3358,"isForceReanalyzing":948},"af93e670-2a5e-4e7d-9a5c-cf83346314b6","2024-04-14T16:32:22.822+00:00","2025-01-13T03:02:10.295+00:00",[],"The-immune-body-cytokine-network-defines-a-social-architecture-of-cell-interactions",{"mag":3250,"keywords":3252,"pmc":3253,"openalex":3255,"abstract":3257,"title":3260,"pm":3263,"doi":3265},{"VOID":3251},"2145619229",{"VI":1248},{"VOID":3254},"1636025",{"VOID":3256},"W2145619229",{"VI":3258,"EN":3259},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Bối cảnh\u003C\u002Fjats:title>\n            \u003Cjats:p>Ba mạng lưới giao tiếp liên tế bào có thể liên quan đến sự tiết cytokine; một mạng lưới hạn chế trong các tế bào của hệ miễn dịch (tế bào miễn dịch), một mạng lưới hạn chế trong các tế bào parenchymal của các cơ quan và mô (tế bào cơ thể), và một mạng lưới liên quan đến các tương tác giữa tế bào miễn dịch và tế bào cơ thể (giao diện miễn dịch-cơ thể). Những kết nối cytokine này xác định phản ứng viêm đối với chấn thương và quá trình lành thương sau đó cũng như các kết quả sinh học của phản ứng miễn dịch thích ứng với các kháng nguyên. Chúng tôi đã khám phá dữ liệu cytokine một cách thông tin để phát hiện cấu trúc mạng lưới nền tảng của ba mạng lưới này.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Chúng tôi hiện báo cáo rằng ba mạng lưới cytokine này nằm trong số những mạng lưới phức tạp dày đặc nhất mà chúng tôi đã nghiên cứu, và mỗi mạng lưới có một hồ sơ đặc trưng của các mô hình ba tế bào cụ thể. Một số kết nối cytokine hợp pháp đã bị từ chối (anti-motifs). Một số tế bào miễn dịch có thể được ghép cặp theo các vị trí vào-ra của chúng trong một cây kiến trúc cytokine có năm tầng: đại thực bào (MΦ) và tế bào B (BC) tạo thành tầng đầu tiên; tầng thứ hai được hình thành bởi tế bào trợ giúp T 1 (Th1) và tế bào trợ giúp T 2 (Th2); tầng thứ ba bao gồm tế bào trình diện (DC), tế bào mast (MAST), tế bào T tự nhiên diệt (NK-T) và những tế bào khác; tầng thứ tư được hình thành bởi bạch cầu trung tính (NEUT) và tế bào T tự nhiên diệt (NK); và tế bào T độc (CTL) đứng độc lập như một tầng thứ năm. Kiến trúc mô hình cytokine ba tế bào của các tế bào trong hệ miễn dịch đặt hệ miễn dịch vào một siêu gia đình bao gồm các mạng xã hội và mạng Internet toàn cầu. Tế bào cơ thể ít được phân tầng rõ ràng hơn, mặc dù các tế bào tham gia vào quá trình lành thương và sự hình thành mạch máu được kết nối nhiều nhất với các tế bào miễn dịch.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Cấu trúc mạng lưới cytokine tạo ra một nền tảng giao tiếp tế bào bẩm sinh, tổ chức kết quả sinh học của việc nhận diện kháng nguyên và viêm. Thông tin cung cấp cái nhìn mới về tổ chức các hệ thống miễn dịch-cơ thể.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Đánh giá viên\u003C\u002Fjats:title>\n            \u003Cjats:p>Bài viết này đã được đánh giá bởi Neil Greenspan, Matthias von Herrath, và Anne Cooke.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Three networks of intercellular communication can be associated with cytokine secretion; one limited to cells of the immune system (immune cells), one limited to parenchymal cells of organs and tissues (body cells), and one involving interactions between immune and body cells (immune-body interface). These cytokine connections determine the inflammatory response to injury and subsequent healing as well as the biologic consequences of the adaptive immune response to antigens. We informatically probed the cytokine database to uncover the underlying network architecture of the three networks.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>We now report that the three cytokine networks are among the densest of complex networks yet studied, and each features a characteristic profile of specific three-cell motifs. Some legitimate cytokine connections are shunned (anti-motifs). Certain immune cells can be paired by their input-output positions in a cytokine architecture tree of five tiers: macrophages (MΦ) and B cells (BC) comprise the first tier; the second tier is formed by T helper 1 (Th1) and T helper 2 (Th2) cells; the third tier includes dendritic cells (DC), mast cells (MAST), Natural Killer T cells (NK-T) and others; the fourth tier is formed by neutrophils (NEUT) and Natural Killer cells (NK); and the Cytotoxic T cell (CTL) stand alone as a fifth tier. The three-cell cytokine motif architecture of immune system cells places the immune system in a super-family that includes social networks and the World Wide Web. Body cells are less clearly stratified, although cells involved in wound healing and angiogenesis are most highly interconnected with immune cells.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>Cytokine network architecture creates an innate cell-communication platform that organizes the biologic outcome of antigen recognition and inflammation. Informatics sheds new light on immune-body systems organization.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Reviewers\u003C\u002Fjats:title>\n            \u003Cjats:p>This article was reviewed by Neil Greenspan, Matthias von Herrath and Anne Cooke.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":3261,"EN":3262},"Mạng lưới cytokine giữa hệ miễn dịch và cơ thể xác định kiến trúc xã hội của các tương tác tế bào","The immune-body cytokine network defines a social architecture of cell interactions",{"VOID":3264},"17062134",{"VOID":3266},"10.1186\u002F1745-6150-1-32",[102],[101],"https:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-1-32",[3271,3292,3311],{"id":3272,"sortIndex":115,"researcher":26,"roles":3273,"affiliations":3274,"properties":3285},"13013194-dc3b-4a62-a449-0ade6d2c19d4",[],[3275],{"id":26,"sortIndex":36,"affiliation":3276,"properties":26},{"id":3277,"createTime":3278,"updateTime":3279,"relativeEntities":3280,"slug":3281,"properties":3282,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a7998222-9c21-40df-8731-2b53367b143a","2024-04-14T16:32:22.847+00:00","2024-08-30T14:36:53.190+00:00",[],"Department-of-Molecular-Cell-Biology-and-Department-of-Physics-of-Complex-Systems-The-Weizmann-Institute-of-Science-Rehovot-76100-Israel",{"title":3283},{"EN":3284},"Department of Molecular Cell Biology and Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot, 76100, Israel",{"openalex":3286,"orcid":3288,"title":3290},{"VOID":3287},"A5010209966",{"VOID":3289},"https:\u002F\u002Forcid.org\u002F0000-0003-1121-5907",{"EN":3291},"Uri Alon",{"id":3293,"sortIndex":36,"researcher":26,"roles":3294,"affiliations":3295,"properties":3306},"4a2e13bf-d3af-438f-a3a4-acf15372a072",[],[3296],{"id":26,"sortIndex":36,"affiliation":3297,"properties":26},{"id":3298,"createTime":3299,"updateTime":3300,"relativeEntities":3301,"slug":3302,"properties":3303,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b3b44977-220b-48fe-956f-f1e3ce7832d1","2024-01-13T11:47:09.340+00:00","2025-02-04T09:17:42.378+00:00",[],"Department-of-Immunology-The-Weizmann-Institute-of-Science-Rehovot-76100-Israel",{"title":3304},{"VI":3305},"Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel",{"openalex":3307,"title":3309},{"VOID":3308},"A5029309088",{"EN":3310},"Ziv Frankenstein",{"id":3312,"sortIndex":114,"researcher":26,"roles":3313,"affiliations":3314,"properties":3320},"8859bef6-644a-47a0-9534-efd552380000",[],[3315],{"id":26,"sortIndex":36,"affiliation":3316,"properties":26},{"id":3298,"createTime":3299,"updateTime":3300,"relativeEntities":3317,"slug":3302,"properties":3318,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3319},{"VI":3305},{"openalex":3321,"orcid":3323,"title":3325},{"VOID":3322},"A5019647534",{"VOID":3324},"https:\u002F\u002Forcid.org\u002F0000-0002-3906-6993",{"EN":3326},"Irun R. Cohen",{"url":26,"publisher":3328,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3329,"slug":663,"properties":3330,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3333,"manageAffiliations":3334,"indexDatabases":3335,"url":26,"thumbnailPath":26,"statistic":3350,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":3331,"title":3332},{"VOID":666},{"EN":668},[],[],[3336,3343],{"id":764,"indexDatabase":3337,"url":779,"indexYears":26,"academicFieldIds":3342,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":3338,"label":3339,"description":3340,"key":775,"publicationTags":3341,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":3344,"url":753,"indexYears":754,"academicFieldIds":3349,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":3345,"label":3346,"description":3347,"key":750,"publicationTags":3348,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":3351,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":3352,"totalCitation":793,"totalCitationByYear":3353,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":3354,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"total":353,"publishYear":26,"statisticByYear":3356},{"2012":53,"2013":52,"2014":50,"2015":162,"2016":114,"2017":114,"2018":59,"2019":162,"2021":53,"2022":114,"2023":59,"2024":115},"2024-04-15T07:05:38.106+00:00",[3359,3363,3367,3371,3374,3377,3381,3384,3388,3392,3396,3400,3404,3407,3411,3415,3419,3423,3427,3431,3435,3439,3443,3447,3451,3455,3458,3462,3466],{"id":26,"text":3360,"url":26,"identifiers":3361},"Parkin J, Cohen B: An overview of the immune system. Lancet 2001, 357: 1777-1789. 10.1016\u002FS0140-6736(00)04904-7",{"doi":3362},"10.1016\u002FS0140-6736(00)04904-7",{"id":26,"text":3364,"url":26,"identifiers":3365},"Delves PJ, Roitt IM: The immune system. First of two parts. N Engl J Med 2000, 343: 37-49. 10.1056\u002FNEJM200007063430107",{"doi":3366},"10.1056\u002FNEJM200007063430107",{"id":26,"text":3368,"url":26,"identifiers":3369},"Delves PJ, Roitt IM: The immune system. Second of two parts. N Engl J Med 2000, 343: 108-117. 10.1056\u002FNEJM200007133430207",{"doi":3370},"10.1056\u002FNEJM200007133430207",{"id":26,"text":3372,"url":26,"identifiers":3373},"Thomson AW, Lotze MT: The Cytokine Handbook. 4th ed edition. Amsterdam, Academic Press; 2003.",{},{"id":26,"text":3375,"url":26,"identifiers":3376},"Ibelgaufts H: COPE: Cytokines Online Pathfinder Encyclopaedia.1997. [http:\u002F\u002Fwww.copewithcytokines.de\u002F]",{},{"id":26,"text":3378,"url":26,"identifiers":3379},"SITE VISIT: Sorting Out Cytokines Science 2000, 288: 1131b. 10.1126\u002Fscience.288.5469.1131b",{"doi":3380},"10.1126\u002Fscience.288.5469.1131b",{"id":26,"text":3382,"url":26,"identifiers":3383},"Oppenheim JJ, Feldmann M, Durum SK, Hirano T, Vilcek J, Nicola NA: The Online Cytokine Reference Database.2000. [http:\u002F\u002Fapresslp.gvpi.net\u002Fapcyto\u002Flpext.dll?f=templates&fn=main-h.htm&2.0]",{},{"id":26,"text":3385,"url":26,"identifiers":3386},"Song S, Sjostrom PJ, Reigl M, Nelson S, Chklovskii DB: Highly nonrandom features of synaptic connectivity in local cortical circuits. PLoS Biol 2005, 3: e68. 10.1371\u002Fjournal.pbio.0030068",{"doi":3387},"10.1371\u002Fjournal.pbio.0030068",{"id":26,"text":3389,"url":26,"identifiers":3390},"Tieri P, Valensin S, Latora V, Castellani GC, Marchiori M, Remondini D, Franceschi C: Quantifying the relevance of different mediators in the human immune cell network. Bioinformatics 2005, 21: 1639-1643. 10.1093\u002Fbioinformatics\u002Fbti239",{"doi":3391},"10.1093\u002Fbioinformatics\u002Fbti239",{"id":26,"text":3393,"url":26,"identifiers":3394},"Kashtan N, Itzkovitz S, Milo R, Alon U: Topological generalizations of network motifs. Phys Rev E Stat Nonlin Soft Matter Phys 2004, 70: 31909.",{"doi":3395},"10.1103\u002FPhysRevE.70.031909",{"id":26,"text":3397,"url":26,"identifiers":3398},"Tsatmali M, Ancans J, Thody AJ: Melanocyte function and its control by melanocortin peptides. J Histochem Cytochem 2002, 50: 125-133.",{"doi":3399},"10.1177\u002F002215540205000201",{"id":26,"text":3401,"url":26,"identifiers":3402},"Clark RA: Fibrin and wound healing. Ann N Y Acad Sci 2001, 936: 355-367.",{"doi":3403},"10.1111\u002Fj.1749-6632.2001.tb03522.x",{"id":26,"text":3405,"url":26,"identifiers":3406},"Cohen IR: Tending Adam's Garden: Evolving The Cognitive Immune Self. San Diego, CA, Academic Press; 2000.",{},{"id":26,"text":3408,"url":26,"identifiers":3409},"Milo R, Itzkovitz S, Kashtan N, Levitt R, Shen-Orr S, Ayzenshtat I, Sheffer M, Alon U: Superfamilies of evolved and designed networks. Science 2004, 303: 1538-1542. 10.1126\u002Fscience.1089167",{"doi":3410},"10.1126\u002Fscience.1089167",{"id":26,"text":3412,"url":26,"identifiers":3413},"Silverstein AM: The Clonal Selection Theory: what it really is and why modern challenges are misplaced. Nat Immunol 2002, 3: 793-796. 10.1038\u002Fni0902-793",{"doi":3414},"10.1038\u002Fni0902-793",{"id":26,"text":3416,"url":26,"identifiers":3417},"Cohen IR: Discrimination and dialogue in the immune system. Semin Immunol 2000, 12: 215-9; discussion 257-344. 10.1006\u002Fsmim.2000.0234",{"doi":3418},"10.1006\u002Fsmim.2000.0234",{"id":26,"text":3420,"url":26,"identifiers":3421},"Cohen IR: The cognitive paradigm and the immunological homunculus. Immunol Today 1992, 13: 490-494. 10.1016\u002F0167-5699(92)90024-2",{"doi":3422},"10.1016\u002F0167-5699(92)90024-2",{"id":26,"text":3424,"url":26,"identifiers":3425},"Milo R, Shen-Orr S, Itzkovitz S, Kashtan N, Chklovskii D, Alon U: Network motifs: simple building blocks of complex networks. Science 2002, 298: 824-827. 10.1126\u002Fscience.298.5594.824",{"doi":3426},"10.1126\u002Fscience.298.5594.824",{"id":26,"text":3428,"url":26,"identifiers":3429},"Goltzman D: Discoveries, drugs and skeletal disorders. Nat Rev Drug Discov 2002, 1: 784-796. 10.1038\u002Fnrd916",{"doi":3430},"10.1038\u002Fnrd916",{"id":26,"text":3432,"url":26,"identifiers":3433},"Carmeliet P: Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000, 6: 389-395. 10.1038\u002F74651",{"doi":3434},"10.1038\u002F74651",{"id":26,"text":3436,"url":26,"identifiers":3437},"Sporns O, Kotter R: Motifs in brain networks. PLoS Biol 2004, 2: e369. 10.1371\u002Fjournal.pbio.0020369",{"doi":3438},"10.1371\u002Fjournal.pbio.0020369",{"id":26,"text":3440,"url":26,"identifiers":3441},"Cohen IR: The cognitive principle challenges clonal selection. Immunol Today 1992, 13: 441-444. 10.1016\u002F0167-5699(92)90071-E",{"doi":3442},"10.1016\u002F0167-5699(92)90071-E",{"id":26,"text":3444,"url":26,"identifiers":3445},"Borrello MA, Phipps RP: The B\u002Fmacrophage cell: an elusive link between CD5+ B lymphocytes and macrophages. Immunol Today 1996, 17: 471-475. 10.1016\u002F0167-5699(96)20031-B",{"doi":3446},"10.1016\u002F0167-5699(96)20031-B",{"id":26,"text":3448,"url":26,"identifiers":3449},"Luster AD: Chemokines--chemotactic cytokines that mediate inflammation. N Engl J Med 1998, 338: 436-445. 10.1056\u002FNEJM199802123380706",{"doi":3450},"10.1056\u002FNEJM199802123380706",{"id":26,"text":3452,"url":26,"identifiers":3453},"Wasserman S, Faust K: Social Network Analysis: Methods And Applications. Cambridge, Cambridge University Press; 1994.",{"doi":3454},"10.1017\u002FCBO9780511815478",{"id":26,"text":3456,"url":26,"identifiers":3457},"Uri Alon lab homepage[http:\u002F\u002Fwww.weizmann.ac.il\u002Fmcb\u002FUriAlon\u002F]",{},{"id":26,"text":3459,"url":26,"identifiers":3460},"Li W, Cai X: Statistical analysis of airport network of China. Phys Rev E Stat Nonlin Soft Matter Phys 2004, 69: 046106.",{"doi":3461},"10.1103\u002FPhysRevE.69.046106",{"id":26,"text":3463,"url":26,"identifiers":3464},"Jeong H, Tombor B, Albert R, Oltvai ZN, Barabasi AL: The large-scale organization of metabolic networks. Nature 2000, 407: 651-654. 10.1038\u002F35036627",{"doi":3465},"10.1038\u002F35036627",{"id":26,"text":3467,"url":26,"identifiers":3468},"Newman MEJ: The Structure and Function of Complex Networks. SIAM Review 2003, 45: 167-256. 10.1137\u002FS003614450342480",{"doi":3469},"10.1137\u002FS003614450342480",{"id":3471,"createTime":3472,"updateTime":3473,"relativeEntities":3474,"slug":3475,"properties":3476,"entityType":846,"verifyStatus":25,"verifyTime":3473,"verifyNote":969,"syncStatus":28,"languages":3491,"translateLanguages":26,"viewCount":36,"primaryUrl":3492,"fullTextUrl":26,"authors":3493,"publicationType":912,"publisherRelationship":3529,"citationCount":535,"citationInfo":3557,"publishDate":3559,"publishYear":3560,"citationAnalyzeStatus":946,"lastCitationAnalyze":3561,"indexDatabases":26,"openAccess":26,"references":3562,"isForceReanalyzing":948},"4d672f26-039a-41eb-b23b-969429451f46","2024-04-11T12:47:56.753+00:00","2025-02-21T23:30:02.004+00:00",[],"Archaeal-origin-of-tubulin",{"mag":3477,"keywords":3479,"pmc":3480,"openalex":3482,"abstract":3484,"title":3485,"pm":3487,"doi":3489},{"VOID":3478},"2110629613",{},{"VOID":3481},"3349469",{"VOID":3483},"W2110629613",{},{"EN":3486},"Archaeal origin of tubulin",{"VOID":3488},"22458654",{"VOID":3490},"10.1186\u002F1745-6150-7-10",[102],"http:\u002F\u002Fbiologydirect.biomedcentral.com\u002Farticles\u002F10.1186\u002F1745-6150-7-10",[3494,3510],{"id":3495,"sortIndex":115,"researcher":26,"roles":3496,"affiliations":3497,"properties":3506},"4e979f8c-bb28-4362-89af-f540829c8cc5",[],[3498],{"id":3499,"sortIndex":36,"affiliation":3500,"properties":3504},"2739aafa-9ceb-403c-82bf-1bda8fe17b4e",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":3501,"slug":2075,"properties":3502,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3503},{"EN":2078},{"title":3505},{"VI":2078},{"openalex":3507,"orcid":3508,"title":3509},{"VOID":1357},{"VOID":1359},{"EN":1361},{"id":3511,"sortIndex":36,"researcher":26,"roles":3512,"affiliations":3513,"properties":3522},"253fc54e-0199-4a5c-b5b8-3523089bf5db",[],[3514],{"id":3515,"sortIndex":36,"affiliation":3516,"properties":3520},"dbeba937-e7d0-4af3-b439-c6376206c606",{"id":2071,"createTime":2072,"updateTime":2073,"relativeEntities":3517,"slug":2075,"properties":3518,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3519},{"EN":2078},{"title":3521},{"VI":2078},{"openalex":3523,"orcid":3525,"title":3527},{"VOID":3524},"A5073344165",{"VOID":3526},"https:\u002F\u002Forcid.org\u002F0000-0002-3633-5123",{"EN":3528},"Natalya Yutin",{"url":26,"publisher":3530,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3531,"slug":663,"properties":3532,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3535,"manageAffiliations":3536,"indexDatabases":3537,"url":26,"thumbnailPath":26,"statistic":3552,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":3533,"title":3534},{"VOID":666},{"EN":668},[],[],[3538,3545],{"id":764,"indexDatabase":3539,"url":779,"indexYears":26,"academicFieldIds":3544,"indexDatabaseRanking":26},{"id":766,"createTime":767,"updateTime":768,"relativeEntities":3540,"label":3541,"description":3542,"key":775,"publicationTags":3543,"standard":26},[],{"EN":771,"VI":771},{"VI":773,"EN":774},[777,778],[781],{"id":740,"indexDatabase":3546,"url":753,"indexYears":754,"academicFieldIds":3551,"indexDatabaseRanking":762},{"id":742,"createTime":743,"updateTime":744,"relativeEntities":3547,"label":3548,"description":3549,"key":750,"publicationTags":3550,"standard":26},[],{"EN":747,"VI":747},{"EN":747,"VI":749},[752],[756,757,758,759,760,761],{"impactFactor":36,"impactFactorByYear":3553,"i10Index":623,"i10IndexLast5Year":52,"totalPublication":791,"totalPublicationByYear":3554,"totalCitation":793,"totalCitationByYear":3555,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":3556,"hindexLast5Year":287,"hindex":287},{"2012":784,"2013":785,"2014":641,"2015":233,"2016":786,"2017":787,"2018":784,"2019":639,"2020":788,"2021":789,"2022":646,"2023":790},{"2006":241,"2007":240,"2008":252,"2009":255,"2010":358,"2011":608,"2012":398,"2013":239,"2014":242,"2015":358,"2016":284,"2017":239,"2018":234,"2019":234,"2020":234,"2021":356,"2022":241,"2023":204,"2024":298},{"2006":795,"2007":796,"2008":797,"2009":166,"2010":798,"2011":799,"2012":618,"2013":800,"2014":258,"2015":627,"2016":801,"2017":349,"2018":802,"2019":165,"2020":142,"2021":336,"2022":283},{"2006":805,"2007":806,"2008":807,"2009":808,"2010":809,"2011":810,"2012":811,"2013":812,"2014":813,"2015":814,"2016":815,"2017":816,"2018":817,"2019":818,"2020":111,"2021":819,"2022":820},{"total":535,"publishYear":26,"statisticByYear":3558},{"2012":59,"2013":53,"2014":52,"2015":158,"2016":135,"2017":53,"2018":116,"2019":135,"2020":135,"2021":111,"2022":52,"2023":53},"2012-01-01",2012,"2024-04-11T14:06:38.753+00:00",[3563,3566,3569,3572,3575,3578,3581,3584,3587,3590,3593,3596,3599,3602,3605,3608,3611,3614,3617,3620,3623,3626,3629,3632,3635,3638,3641,3644,3647,3650,3652,3654,3657,3660,3663,3665,3668,3671,3674,3677,3680,3683,3686,3689],{"id":26,"text":3564,"url":26,"identifiers":3565},"10.1146\u002Fannurev.biochem.69.1.277",{"doi":3564},{"id":26,"text":3567,"url":26,"identifiers":3568},"10.1007\u002Fs12033-009-9193-5",{"doi":3567},{"id":26,"text":3570,"url":26,"identifiers":3571},"10.1016\u002Fj.mib.2003.10.016",{"doi":3570},{"id":26,"text":3573,"url":26,"identifiers":3574},"10.1073\u002Fpnas.012516899",{"doi":3573},{"id":26,"text":3576,"url":26,"identifiers":3577},"10.1371\u002Fjournal.pbio.1001213",{"doi":3576},{"id":26,"text":3579,"url":26,"identifiers":3580},"10.1074\u002Fjbc.M111.230094",{"doi":3579},{"id":26,"text":3582,"url":26,"identifiers":3583},"10.1073\u002Fpnas.0502859102",{"doi":3582},{"id":26,"text":3585,"url":26,"identifiers":3586},"10.1128\u002FMMBR.00021-10",{"doi":3585},{"id":26,"text":3588,"url":26,"identifiers":3589},"10.1111\u002Fj.1574-6976.2011.00316.x",{"doi":3588},{"id":26,"text":3591,"url":26,"identifiers":3592},"10.1038\u002Fnsb0698-451",{"doi":3591},{"id":26,"text":3594,"url":26,"identifiers":3595},"10.1007\u002Fs00709-005-0152-0",{"doi":3594},{"id":26,"text":3597,"url":26,"identifiers":3598},"10.1186\u002F1745-6150-5-33",{"doi":3597},{"id":26,"text":3600,"url":26,"identifiers":3601},"10.1002\u002Fbies.20601",{"doi":3600},{"id":26,"text":3603,"url":26,"identifiers":3604},"10.1371\u002Fjournal.pone.0016626",{"doi":3603},{"id":26,"text":3606,"url":26,"identifiers":3607},"10.1128\u002FJB.05717-11",{"doi":3606},{"id":26,"text":3609,"url":26,"identifiers":3610},"10.1016\u002Fj.devcel.2011.05.015",{"doi":3609},{"id":26,"text":3612,"url":26,"identifiers":3613},"10.1126\u002Fscience.1165322",{"doi":3612},{"id":26,"text":3615,"url":26,"identifiers":3616},"10.1016\u002Fj.tim.2009.08.003",{"doi":3615},{"id":26,"text":3618,"url":26,"identifiers":3619},"10.1038\u002Fnrmicro2406",{"doi":3618},{"id":26,"text":3621,"url":26,"identifiers":3622},"10.1073\u002Fpnas.0809467105",{"doi":3621},{"id":26,"text":3624,"url":26,"identifiers":3625},"10.1111\u002Fj.1365-2958.2011.07834.x",{"doi":3624},{"id":26,"text":3627,"url":26,"identifiers":3628},"10.1093\u002Fmolbev\u002Fmsm069",{"doi":3627},{"id":26,"text":3630,"url":26,"identifiers":3631},"10.1186\u002F1745-6150-4-11",{"doi":3630},{"id":26,"text":3633,"url":26,"identifiers":3634},"10.1186\u002F1745-6150-4-39",{"doi":3633},{"id":26,"text":3636,"url":26,"identifiers":3637},"10.1093\u002Fnar\u002Fgkq1228",{"doi":3636},{"id":26,"text":3639,"url":26,"identifiers":3640},"10.1016\u002Fj.tim.2011.09.002",{"doi":3639},{"id":26,"text":3642,"url":26,"identifiers":3643},"10.1186\u002F1745-6150-4-9",{"doi":3642},{"id":26,"text":3645,"url":26,"identifiers":3646},"10.1111\u002Fj.1365-2958.2011.07635.x",{"doi":3645},{"id":26,"text":3648,"url":26,"identifiers":3649},"10.1016\u002FS0955-0674(00)00173-3",{"doi":3648},{"id":26,"text":1930,"url":26,"identifiers":3651},{"doi":1930},{"id":26,"text":2351,"url":26,"identifiers":3653},{"doi":2351},{"id":26,"text":3655,"url":26,"identifiers":3656},"10.1093\u002Fmolbev\u002Fmsn108",{"doi":3655},{"id":26,"text":3658,"url":26,"identifiers":3659},"10.1371\u002Fjournal.pone.0009490",{"doi":3658},{"id":26,"text":3661,"url":26,"identifiers":3662},"10.1126\u002Fscience.155.3760.279",{"doi":3661},{"id":26,"text":1950,"url":26,"identifiers":3664},{"doi":1950},{"id":26,"text":3666,"url":26,"identifiers":3667},"10.1098\u002Frspb.2001.1862",{"doi":3666},{"id":26,"text":3669,"url":26,"identifiers":3670},"10.1080\u002F10635150290069913",{"doi":3669},{"id":26,"text":3672,"url":26,"identifiers":3673},"10.1111\u002Fj.1742-4658.2005.04945.x",{"doi":3672},{"id":26,"text":3675,"url":26,"identifiers":3676},"10.1093\u002Fnar\u002Fgkl731",{"doi":3675},{"id":26,"text":3678,"url":26,"identifiers":3679},"10.1098\u002Frspb.2011.1581",{"doi":3678},{"id":26,"text":3681,"url":26,"identifiers":3682},"10.1093\u002Fbioinformatics\u002Fbti191",{"doi":3681},{"id":26,"text":3684,"url":26,"identifiers":3685},"10.1002\u002Fbies.201100045",{"doi":3684},{"id":26,"text":3687,"url":26,"identifiers":3688},"10.1016\u002Fj.resmic.2010.09.016",{"doi":3687},{"id":26,"text":3690,"url":26,"identifiers":3691},"10.1126\u002Fscience.1171243",{"doi":3690}]