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C., Wadhwa, S. (2007) Age related decrease in rod bipolar density of human retina: An immunohistochemical study. J. Biosci. 32, 293–298.\nAnderson, D. R. (1969) Ultrastructure of human and monkey lamina cribrosa and optic nerve head. Arch. Ophthalmol. 82, 800–814.\nAnderson, D. R. (1970) Ultrastructure of the optic nerve head. Arch. Ophthalmol. 83, 63–73.\nAnderson, D.R., Hoyt, W. F. (1969) Ultrastructure of intraorbital portion of human and monkey optic nerve. Arch. Ophthalmol. 82, 506–530.\nAnderson, D.R., Hoyt, W.F., Hogan, M. J. (1967) The fine structure of the astroglia in the human optic nerve and optic nerve head. Trans. Am. Ophthalmol. Soc. 65, 275–305.\nBalaszi, A.G., Rootman, J., Drance, S.M., Schulzer, M., Douglas, G. R. (1984) The effect of age on the nerve fibre population of the human optic nerve. Am. J. Ophthalmol. 97, 760–766.\nBunge, R. P. (1968) Glial cells and the central myelin sheath. Physiol. Rev. 48, 197–210.\nCurcio, C. A. (2001) Photoreceptor topography in ageing and age-related maculopathy Ey. 15, 376–383.\nElkington, A.R., Inman, C.B., Steart, P.V., Weller, R. O. (1990) The structure of the lamina cribrosa of the human eye: an immunohistochemical and electron microscopical study. Ey. 4, 42–57.\nGao, H., Hollyfield, J. G. (1992) Aging of the human retina. Invest. Ophthalmol. Vis. Sci. 33, 1–17.\nHarman, A., Abrahams, B., Moore, S., Hoskins, R. (2000) Neuronal density in the human retinal ganglion cell layer from 16 to 77 years. Anat. Rec. 260, 24–131.\nHarwerth, R.S., Wheat, J.L., Rangaswamy, N. V. (2008) Age-related losses of retinal ganglion cells and axons. Invest. Ophthalmol. Vis. Sci. 49, 4437–4443.\nHernandez, M.R., Luo, X.X., Andrzejewska, W., Neufeld, A. H. (1989) Age-related changes in the extracellular matrix of the human optic nerve head. Am. J. Ophthalmol. 107, 476–484.\nKim, S.U., McMorris, F.A., Sprinkle, T. J. (1984) Immunofluorescence demonstration of 2’:3’-cyclic-nucleotide 3’-phosphodiesterase in cultured oligodendrocytes of mouse, rat, calf and human. Brain Res. 300, 195–199.\nLei, Y., Garrahan, N., Hermann, B., Fautsch, M.P., Johnson, D.H., Hernandez, M.R., Boulton, M., Morgan, J. E. (2011) Transretinal degeneration in ageing human retina: a multiphoton microscopy analysis. Br. J. Ophthalmol. 95, 727–730.\nNag, T. C., Wadhwa, S., Chaudhury, S. (2006) The occurrence of cone inclusions in the aging human retina and their possible effects upon vision. An electron microscope study. Brain Res. Bull. 71, 224–232.\nNorenberg, M. D. (1979) Distribution of glutamine synthetase in the rat central nervous system. J. Histochem. Cytochem. 27, 756–762.\nPenfield, W. (1932) Neuroglia: normal and pathological. In: Penfield, W. (ed.) Cytology and Cellular Pathology in the Nervous System, vol. 2, Hoeber, New York, pp. 421–479.\nPeters, A. (2002) The effects of normal aging on myelin and nerve fibers: a review. J. Neurocytol. 31, 581–593.\nPeters, A., Palay, S.L., deF Webster, H. (1990) The fine structure of the nervous system. In: Neurons and Their Supporting Cells, 3rd ed., Oxford University Press, New York.\nRepka, M.X., Quigley, H. A. (1989) The effect of age on normal human optic nerve fiber number and diameter. Ophthalmolog. 96, 26–31.\nSandell, J.H., Peters, A. (2001) Effects of age on nerve fibers in the rhesus monkey optic nerve. J. Comp Neurol. 429, 541–553.\nSandell, J.H., Peters, A. (2002) Effects of age on the glial cells in the rhesus monkey optic nerve. J. Comp. Neurol. 445, 13–28.\nTrivino, A., Ramirez, J.M., Salazar, J.J., Ramirez, A. I. (1996) Immunohistochemical study of human optic nerve head astroglia. Vision Res. 36, 2015–2028.\nYe, H., Hernandez, M. R. (1995) Heterogeneity of astrocytes in human optic nerve head. J. Comp. Neurol. 362, 441–452.",{"EN":121},"We examined age-related changes in the human optic nerve (ON) from 10 postmortem donor eye samples (age: 21- to 94-year-old). In aged ON, many axons showed paucity of cytoskeleton, and possessed disorganized myelin that remained in the extracellular space. Lipid inclusions were detected in glia, as stained by oil red O, and these accumulated with aging. To identify and confirm which glial cell type possessed lipid inclusions, we performed immunohistochemistry (IHC) and transmission electron microscopy (TEM). Comparisons were made from TEM features and size of the glia immunolabeled with glial fibrillary acidic protein and glutamine synthetase (markers for astrocytes) and 2’,3’-cyclic nucleotide 3’-phos-phodiesterase (a marker for oligodendrocytes). It was found that lipid inclusions were restricted to the astrocytes having larger perikarya than the oligodendrocytes (IHC) and possessing filaments in cytoplasm (TEM). These astrocytes also possessed myelin debris and it is thus likely that those inclusions originated from degenerated myelin of the ON axons. These data indicate that astrocytes play a role in phagocytosis and clearance of disorganized myelin in aging human ON.",{"EN":123},"Accumulation of Lipid Inclusions in Astrocytes of Aging Human Optic Nerve",{"VOID":125},"10.1556\u002FABiol.63.2012.Suppl.1.6","PUBLICATION","http:\u002F\u002Fwww.akademiai.com\u002Fdoi\u002Fabs\u002F10.1556\u002FABiol.63.2012.Suppl.1.6",[129,146],{"id":130,"sortIndex":19,"researcher":18,"roles":131,"affiliations":133,"properties":143},"c97c310c-a239-4087-b438-fd45440d3944",[132],"AUTHOR",[134],{"id":18,"sortIndex":19,"affiliation":135,"properties":18},{"id":136,"createTime":137,"updateTime":137,"relativeEntities":138,"slug":18,"properties":139,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"802d6717-ccfd-4a7f-9f43-5319b013900f","2023-11-30T23:59:44.148+00:00",[],{"title":140},{"VI":141},"Department of Anatomy, Neurobiology Laboratory, All India Institute of Medical Sciences, New Delhi, India","AFFILIATION",{"title":144},{"VI":145},"T. 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Nag",{"id":147,"sortIndex":148,"researcher":18,"roles":149,"affiliations":150,"properties":156},"0c119d23-1257-415c-931f-8eb7edff1f33",1,[132],[151],{"id":18,"sortIndex":19,"affiliation":152,"properties":18},{"id":136,"createTime":137,"updateTime":137,"relativeEntities":153,"slug":18,"properties":154,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":155},{"VI":141},{"title":157},{"VI":158},"Shashi Wadhwa","ARTICLE",{"url":127,"publisher":161,"properties":180},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":162,"slug":10,"properties":163,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":166,"manageAffiliations":167,"indexDatabases":168,"url":18,"thumbnailPath":18,"statistic":175,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":164,"title":165},{"VOID":13},{"EN":15},[],[],[169],{"id":24,"indexDatabase":170,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":171,"label":172,"description":173,"key":34,"publicationTags":174,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":176,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":177,"totalCitation":68,"totalCitationByYear":178,"totalCitationPerPublication":83,"totalCitationPerPublicationByYear":179,"hindexLast5Year":107,"hindex":107},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":46,"2019":48,"2020":49},{"1997":53,"1998":54,"1999":55,"2000":53,"2001":55,"2002":56,"2003":57,"2004":58,"2005":58,"2006":56,"2007":59,"2008":60,"2009":61,"2010":50,"2011":62,"2012":63,"2013":58,"2014":64,"2015":57,"2016":65,"2017":66,"2018":58,"2019":67},{"1997":59,"1998":70,"1999":57,"2000":71,"2001":72,"2002":73,"2003":58,"2004":74,"2005":75,"2006":76,"2007":76,"2008":77,"2009":76,"2010":78,"2011":79,"2012":80,"2013":81,"2014":58,"2015":59,"2016":59,"2017":82,"2018":64},{"1997":85,"1998":86,"1999":87,"2000":88,"2001":89,"2002":90,"2003":91,"2004":92,"2005":93,"2006":94,"2007":95,"2008":96,"2009":97,"2010":98,"2011":99,"2012":100,"2013":101,"2014":102,"2015":103,"2016":104,"2017":105,"2018":106},{"volume":181,"pages":183},{"VOID":182},"63",{"VOID":184},"54-64","2012-12-30",2012,false,{"id":189,"createTime":190,"updateTime":191,"relativeEntities":192,"slug":193,"properties":194,"entityType":126,"verifyStatus":203,"verifyTime":191,"verifyNote":204,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":205,"fullTextUrl":18,"authors":206,"publicationType":159,"publisherRelationship":317,"citationCount":18,"citationInfo":18,"publishDate":342,"publishYear":343,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":187},"c99f698e-cf50-4aa6-8836-f93decb8284a","2024-02-15T01:02:17.634+00:00","2024-12-13T23:56:17.129+00:00",[],"Analysis-of-the-Applicability-of-Molecular-Markers-Linked-to-the-PVY-Extreme-Resistance-Gene-Rysto-and-the-Identification-of-New-Markers",{"references":195,"abstract":197,"title":199,"doi":201},{"VOID":196},"Brigneti, G., Garcia-Mas, J., Banlcombe, D. C. (1997) Molecular mapping of the potato virus Y. resistance gene Rysto in potato. Theor. Appl. Genet. 94, 198–203.\nCelebi-Toprak, F., Slack, S. A., Jahn, M. M. (2002) A. new gene, Nytbr, for hypersensitivity to potato virus Y. from Solatium tuberosum. Theor. Appl. Genet. 104, 669–674.\nCockerham, G. (1943) Potato breeding for virus resistance. Ann. Appl. Biol. 30, 105–108.\nFlis, B., Hennig, J., Strzelczyk-Zyta, D., Gebhardt, C., Marczewski, W. (2005) The Ry-fsto gene from Solanum stoloniferum for extreme resistant to Potato virus Y. maps to potato chromosome XII and is diagnosed by PCR marker GP122718 in PVY resistant potato cultivars. Mol. Breed, 15, 95–101.\nGebhardt C., Valkonen, J. P. T. (2001) Organization of genes controlling disease resistance in the potato genome. Annu. Rev. Phytopathol. 39, 79–102.\nHamalainen, H., Sorri, V. A., Watanabe, K. N., Gebhardt, C., Valkonen, J. P. T. (1998) Molecular examination of a chromosome region that controls resistance to potato Y. and A. potyviruses in potato. Theor. Appl. Genet. 96, 1036–1043.\nHamalainen, J. H., Watanabe, K. N., Valkonen, J. P. T., Arihara, A., Plaisted, R. L., Pehu, E., Miller, L., Slack, S. A. (1997) Mapping and marker-assisted selection for a gene for extreme resistance to potato virus Y. Theor. Appl. Genet. 94, 192–197.\nHosaka, K., Hosaka, Y., Mori, M., Maida, T., Matsunaga, H. (2001) Detection of a simplex RAPD marker linked to resistance to potato virus Y. in a tetraploid potato. Am. J. Potato Res. 78, 191–196.\nKasai, K., Morikawa, Y., Sorri, V. A., Valkonen, I. P. T., Gebhardt, G., Watanabe, K. N. (2000) Development of SCAR markers to the PVY resistance gene Ryadg based on a common feature of plant disease resistance genes. Genome 43, 1–8.\nMilbourne, D., Meyer, R. C., Collins, A. I., Ramsay, R. D., Gebhardt, C., Waugh, R. (1998) Isolation, characterisation and mapping of simple sequence repeat loci in potato. Mol. Gen. Genet. 259, 233–245.\nRoss, H. (1986) Potato Breeding - Problems and Perspectives. Paul Parey, Berlin & Hamburg.\nSolomon-Blackburn, R. M., Barker, H. (2001) A. review of host major-gene resistance to potato viruses X., Y, A. and V. in potato genes, genetics and mapped locations. Heredity 86, 8–16.\nSong, Y. S. (2004) Genetic marker analysis in potato for extreme resistance (Rysto) to PVY and for chip quality after long term storage at 4 °C. PhD Dissertation: University of Technology, Munchen, Germany.\nSong, Y. S., Hepting, L., Schweizer, G., Hartl, L., Wenzel, G., Schwarzfischer, A. (2005) Mapping of extreme resistance to PVY (Rysto) on chromosome XII using anther-culture-derived primary dihap-loid potato lines. Theor. Appl. Genet. Ill, 879–887.\nTakacs, A., Kazinczi, G., Horvath, J., Bosze, Z., Pribek, D. (1999) Resistance of new wild Solanum species to NTN strain of potato Y. potyvirus (PVYNTN). Meded. Fac. Landbouww. Univ. Gent 64\u002F3b, 513–520.\nWalbot, V., Warren, C. (1988) Regulation of Mu element copy number in maize line with an active or inactive mutator transposable element system. Mol. Gen. Genet. 211, 27–34.",{"EN":198},"In this study molecular markers linked to the Rysto gene, which originates from the wild potato species Solanum stoloniferum and confers extreme resistance against PVY, were identified and the applicability of recently published Rysto markers was analyzed. Three RAPD markers covering a total distance of 8.60 cM were detected in this experiment. The closest of these markers was located 0.53 cM from the gene. From among the published markers only one had diagnostic value in the experimental plant material, and mapped 2.95 cM from the gene, on the side opposite the RAPD markers developed in the present study. All the markers analyzed were present in Solanum stoloniferum accessions, irrespective of their resistance, indicating that these sequences are linked to the locus and not exclusively to the dominant allele of the Rysto gene in the wild species. The inapplicability of several published markers indicates that the genetic background is decisive in this tetraploid and highly heterozygous species. This means that it may be necessary to develop markers from the breeding material itself, until the resistance gene is not cloned and cannot be used as a selection marker in marker-assisted selection.",{"EN":200},"Analysis of the Applicability of Molecular Markers Linked to the PVY Extreme Resistance Gene Rysto, and the Identification of New Markers",{"VOID":202},"10.1556\u002FABiol.59.2008.2.6","VERIFIED","Auto Verify","https:\u002F\u002Fakjournals.com:443\u002Fview\u002Fjournals\u002F018\u002F59\u002F2\u002Farticle-p195.xml",[207,222,238,250,266,279,291,304],{"id":208,"sortIndex":19,"researcher":18,"roles":209,"affiliations":210,"properties":219},"fdb1fc94-bb27-4952-b312-22ed0e78620c",[132],[211],{"id":18,"sortIndex":19,"affiliation":212,"properties":18},{"id":213,"createTime":214,"updateTime":214,"relativeEntities":215,"slug":18,"properties":216,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"619e5ecd-32f0-4627-940c-756847f82631","2024-02-15T01:02:17.689+00:00",[],{"title":217},{"VI":218},"Department of Plant Sciences and Biotechnology, University of Pannonia, Keszthely, Hungary",{"title":220},{"VI":221},"I. 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Taller",{"id":251,"sortIndex":252,"researcher":18,"roles":253,"affiliations":254,"properties":263},"49e51c4c-8fe0-44e4-b11f-c197439eac35",2,[132],[255],{"id":18,"sortIndex":19,"affiliation":256,"properties":18},{"id":257,"createTime":258,"updateTime":258,"relativeEntities":259,"slug":18,"properties":260,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"35fb4614-ff5f-4b52-8b70-3ffb096ec2b4","2024-02-15T01:02:18.012+00:00",[],{"title":261},{"VI":262},"Potato Research Center, University of Pannonia, Keszthely, Hungary",{"title":264},{"VI":265},"I. 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T., Monafo, W. W., Mustoe, T. A. (1989) Topical silicone gel: A. new treatment for hypertrophic scars. Surgery 106, 781–784.\nAhn, S. T., Monafo, W. W., Mustoe, T. A. (1991) Topical silicone gel for the prevention and treatment of hypertrophic scars. Arch. Surg. 126, 429–503.\nAl-Attar, A., Mess, S., Thomassen, J. M., Kauffman, C. L., Davison, S. P. (2006) Keloid pathogenesis and treatment. Plast. Reconstruct. Surg. 117, 286–300.\nBayat, A., McGrouther, D. A., Ferguson, M. W. J. (2003) Skin scarring. Br. Med. J. 326, 88–92.\nCarr-Collins, J. A., Evans, J. H., Leung, K. S. (1992) Pressure techniques for prevention of hypertrophic scar. Clin. Plast. Surg. 19, 733–736.\nFulton, J. E. Jr. (1995) Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars. Dermatol. Surg. 21, 947–951.\nKelemen, O., Kollar, L., Menyhei, G. (2007) A. comparative clinical study of treatment of hypertrophic scars with either intralaesional steroid or silicone gel sheeting. Hung. Surg. 60, 297–300. (Hungarian)\nKischer, C. W. (1993) Contributions of electron microscopy to the study of hypertrophic scar and related lesions. Scanning Microsc. 7, 921–930.\nKischer, C. W., Shetlar, M. R. (1974) Collagen and mucopolysaccharides in the hypertrophic scar. Connect. Tissue Res. 2, 205–213.\nKovacs, E. J., DiPietro, L. A. (1994) Fibrogenic cytokines and connective tissue production. FASEB J. 8, 854–857.\nMuir, J. F. K. (1990) On the nature of keloids and hypertrophic scars. Br. J. Plast. Surg. 43, 61–69.\nMustoe, T. A., Cooter, R., Gold, M. (2002) International clinical guide for scar management. Plast Reconstr. Surg. 110, 560–571.\nNiessen, F. B., Spauwen, P. H. M., Schwalkwijk, J., Kon, M. (1999) On the nature of hypertrophic scars and keloids: A. review. Plast. Reconstruct. Surg. 104, 1435–1458.\nSaulis, A., Chao, J., Telser, A., Mogford, J. E., Mustoe, T. A. (2002) Silicone occlusive products in the treatment of hypertrophic scar in the rabbit ear hypertrophic scar model. Aesthetic Surg. J. 22, 147–153.\nScott, P., Gahary, A., Chambers, M. (1994) Biological basis of hypertrophic scarring. Adv. Struct. Bio. 3, 157–164.\nSproat, J. E., Dalcin, A., Weitauer, N., Roberts, R. S. (1992) Hypertrophic sternal scars: silicone gel sheet versus Kenalog injection treatment. Plast. Reconstr. Surg. 90, 988–992.\nSu, C. W., Alizadeth, K., Lee, R. C. (1998) The scar problem. Clin. Plast. Surg. 25, 451–159.\nWidgerow, A. D., Chait, L. A., Stals, R., Stals, P. J. (2000) New innovations in scar management. Aesthetic Plast. Surg. 24, 227–231.",{"EN":352},"The linear hypertrophic scar has become the most common type of pathologic scarring. Silicone-gel sheeting is the first line therapy while intralesional steroid is the second. A. light and electron microscopic analysis was carried out to reveal differences in tissue reaction following the two different treatments. Two groups of 12 patients each were treated for 4 months. For the first group, diluted Triamcinolone acetonide was injected until an inactive state was achieved. The other group of patients was treated with silicone-gel sheeting. The scars were examined every two weeks and their appearance documented. After reaching the expected therapeutic response, inactive scars were removed. The excised scars were evaluated through light microscopic histopathology and electron microscopy. The light and electron microscopic observations revealed marked differences following treatments. The activity of fibroblasts and the numbers of collagen fibers forming bundles decreased and the orientation of the collagen fibers was more variable in the treated scars. The amount of elastic fibers increased after both steroid and silicone-gel sheeting treatment. Vascularization was also slightly changed, with more capillaries and fewer pre-capillary arteries detected in the treated scars. Both treatments resulted in the same decrease in score but steroid treatment was more rapid in onset. We suggest that the two different treatments work through different mechanisms, although the final functional outcome is similar.",{"EN":354},"Morphological Analysis of the Connective Tissue Reaction in Linear Hypertrophic Scars Treated with Intralesional Steroid or Silicone-Gel Sheeting. A Light and Electron Microscopic Study",{"VOID":356},"10.1556\u002FABiol.59.2008.2.1","https:\u002F\u002Fakjournals.com:443\u002Fview\u002Fjournals\u002F018\u002F59\u002F2\u002Farticle-p129.xml",[359,374,389,401,416],{"id":360,"sortIndex":19,"researcher":18,"roles":361,"affiliations":362,"properties":371},"0da41438-fb97-47f5-a580-f8de45ea7bb8",[132],[363],{"id":18,"sortIndex":19,"affiliation":364,"properties":18},{"id":365,"createTime":366,"updateTime":366,"relativeEntities":367,"slug":18,"properties":368,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8b5291df-668f-4137-b5d6-38d2007e68e9","2024-01-08T18:13:51.044+00:00",[],{"title":369},{"VI":370},"Department of Surgery, University of Pécs, Pécs, Hungary",{"title":372},{"VI":373},"O. Kelemen",{"id":375,"sortIndex":148,"researcher":18,"roles":376,"affiliations":377,"properties":386},"bec8f733-b1b1-48bb-915e-0228c5032383",[132],[378],{"id":18,"sortIndex":19,"affiliation":379,"properties":18},{"id":380,"createTime":381,"updateTime":381,"relativeEntities":382,"slug":18,"properties":383,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"f0a6e9f1-1a56-4fc0-8946-30fcb220f6ea","2024-02-08T23:55:42.240+00:00",[],{"title":384},{"VI":385},"Department of Pathology, Baranya County Hospital, Pécs, Hungary",{"title":387},{"VI":388},"G. Hegedűs",{"id":390,"sortIndex":252,"researcher":18,"roles":391,"affiliations":392,"properties":398},"a1d747ca-796a-484a-8ee2-8806aa073f76",[132],[393],{"id":18,"sortIndex":19,"affiliation":394,"properties":18},{"id":365,"createTime":366,"updateTime":366,"relativeEntities":395,"slug":18,"properties":396,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":397},{"VI":370},{"title":399},{"VI":400},"L. Kollár",{"id":402,"sortIndex":293,"researcher":18,"roles":403,"affiliations":404,"properties":413},"363bb113-e4e3-43c7-87d0-73f874b014da",[132],[405],{"id":18,"sortIndex":19,"affiliation":406,"properties":18},{"id":407,"createTime":408,"updateTime":408,"relativeEntities":409,"slug":18,"properties":410,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"3a72b3db-8113-4ef0-83ad-66ebcd180d61","2024-01-14T00:10:07.794+00:00",[],{"title":411},{"VI":412},"Central Electron Microscopic Laboratory, Faculty of Medicine, University of Pécs, Pécs, Hungary",{"title":414},{"VI":415},"L. Seress",{"id":417,"sortIndex":306,"researcher":18,"roles":418,"affiliations":419,"properties":425},"3fb586e2-10bd-458c-9731-339c73293dfe",[132],[420],{"id":18,"sortIndex":19,"affiliation":421,"properties":18},{"id":365,"createTime":366,"updateTime":366,"relativeEntities":422,"slug":18,"properties":423,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":424},{"VI":370},{"title":426},{"VI":427},"G. Menyhei",{"url":357,"publisher":429,"properties":448},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":430,"slug":10,"properties":431,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":434,"manageAffiliations":435,"indexDatabases":436,"url":18,"thumbnailPath":18,"statistic":443,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":432,"title":433},{"VOID":13},{"EN":15},[],[],[437],{"id":24,"indexDatabase":438,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":439,"label":440,"description":441,"key":34,"publicationTags":442,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":444,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":445,"totalCitation":68,"totalCitationByYear":446,"totalCitationPerPublication":83,"totalCitationPerPublicationByYear":447,"hindexLast5Year":107,"hindex":107},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":46,"2019":48,"2020":49},{"1997":53,"1998":54,"1999":55,"2000":53,"2001":55,"2002":56,"2003":57,"2004":58,"2005":58,"2006":56,"2007":59,"2008":60,"2009":61,"2010":50,"2011":62,"2012":63,"2013":58,"2014":64,"2015":57,"2016":65,"2017":66,"2018":58,"2019":67},{"1997":59,"1998":70,"1999":57,"2000":71,"2001":72,"2002":73,"2003":58,"2004":74,"2005":75,"2006":76,"2007":76,"2008":77,"2009":76,"2010":78,"2011":79,"2012":80,"2013":81,"2014":58,"2015":59,"2016":59,"2017":82,"2018":64},{"1997":85,"1998":86,"1999":87,"2000":88,"2001":89,"2002":90,"2003":91,"2004":92,"2005":93,"2006":94,"2007":95,"2008":96,"2009":97,"2010":98,"2011":99,"2012":100,"2013":101,"2014":102,"2015":103,"2016":104,"2017":105,"2018":106},{"volume":449,"pages":450},{"VOID":339},{"VOID":451},"129-145",{"id":453,"createTime":454,"updateTime":455,"relativeEntities":456,"slug":457,"properties":458,"entityType":126,"verifyStatus":203,"verifyTime":455,"verifyNote":204,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":467,"fullTextUrl":18,"authors":468,"publicationType":159,"publisherRelationship":508,"citationCount":18,"citationInfo":18,"publishDate":533,"publishYear":534,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":187},"c98421c1-952e-4442-9d4d-f5777def5307","2023-11-30T20:49:19.594+00:00","2025-01-17T23:55:42.425+00:00",[],"Effect-of-Silver-Nanoparticles-on-Phenolic-Compounds-Production-and-Biological-Activities-in-Hairy-Root-Cultures-of-Cucumis-Anguria",{"references":459,"abstract":461,"title":463,"doi":465},{"VOID":460},"Chen, W. H., Xu, C. M., Zeng, J. L., Zhao, B., Wang, X. D., Wang, Y. C. (2007) Improvement of echinacoside and acteoside production by two-stage elicitation in cell suspension culture of Cistanche deserticola. World J. Microbiol. Biotechnol. 23, 1451–1458.\nChung, I. M., Rekha, K., Rajakumar, G., Thiruvengadam, M. (2017) Jasmonic and salicylic acids enhanced phytochemical production and biological activities in cell suspension cultures of spine gourd (Momordica dioica Roxb). Acta Biol. Hung. 68, 88–100.\nFazal, H., Abbasi, B. H., Ahmad, N., Ali, M. (2016) Elicitation of medicinally important antioxidant secondary metabolites with silver and gold nanoparticles in callus cultures of Prunella vulgaris L. Appl. Biochem. Biotechnol. 180, 1076–1092.\nGe, X., Wu, J. (2005) Tanshinone production and isoprenoid pathways in Salvia miltiorrhiza hairy roots induced by Ag+ and yeast elicitor. Plant Sci. 168, 487–491.\nGhanati, F., Bakhtiarian, S. (2013) Changes of natural compounds of Artemisia annua L. by methyl jasmonate and silver nanoparticles. Adv. Env. Biol. 7, 2251–2258.\nGhanati, F., Bakhtiarian, S., Parast, B. M., Behrooz, M. K. (2014) Production of new active phyto-compounds by Achillea millefolium L. after elicitation with silver nanoparticles and methyl jas-monate. Biosci. Biotechnol. Res. Asia 11, 391–399.\nGhasemi, B., Hosseini, R., Nayeri, F. D. (2015) Effects of cobalt nanoparticles on artemisinin production and gene expression in Artemisia annua. Turk. J. Bot. 39, 769–777.\nJamshidi, M., Ghanati, F., Rezaei, A., Bemani, E. (2016) Change of antioxidant enzymes activity of hazel (Corylus avellana L.) cells by AgNPs. Cytotechnology 68, 525–530.\nKrishnaraj, C., Jagan, G., Ramachandran, R., Abirami, S. M., Mohan, N., Kalaichelvan, P. T. (2012) Effect of biologically synthesized silver nanoparticles on Bacopa monnieri L. Wettst. plant growth metabolism. Process Biochem. 47, 651–658.\nLee, W. M., Kwak, J. I., An, Y. J. (2012) Effect of silver nanoparticles in crop plants Phaseolus radiatus and Sorghum bicolor: media effect on phytotoxicity. Chemosphere 86, 491–499.\nLi, B., Wang, B., Li, H., Peng, L., Ru, M., Liang, Z., Yan, X., Zhu, Y. (2016) Establishment of Salvia castanea Diels f. tomentosa Stib. hairy root cultures and the promotion of tanshinone accumulation and gene expression with Ag+, methyl jasmonate, and yeast extract elicitation. Protoplasma 253, 87–100.\nMurashige, T., Skoog, F. (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 15, 473–497.\nQian, H., Peng, X., Han, X., Ren, J., Sun, L., Fu, Z. (2013) Comparison of the toxicity of silver nanoparticles and silver ions on the growth of terrestrial plant model Arabidopsis thaliana. J. Env. Sci. 25, 1947–1956.\nShakeran, Z., Keyhanfar, M., Asghari, G., Ghanadian, M. (2015) Improvement of atropine production by different biotic and abiotic elicitors in hairy root cultures of Datura metel. Turk. J. Biol. 39, 111–118.\nSpinoso-Castillo, J. L., Chavez-Santoscoy, R. A., Bogdanchikova, N., Pérez-Sato, J. A., Morales-Ramos, V., Bello-Bello, J. J. (2017) Antimicrobial and hormetic effects of silver nanoparticles on in vitro regeneration of vanilla (Vanilla planifolia Jacks. ex Andrews) using a temporary immersion system. Plant Cell Tiss. Org. Cult. 129, 195–207.\nThiruvengadam, M., Chung, I. M. (2015) Selenium, putrescine, and cadmium infuence health-promoting phytochemicals and molecular-level effects on turnip (Brassica rapa ssp. rapa). Food Chem. 173, 185–193.\nThiruvengadam, M., Gurunathan, S., Chung, I. M. (2015) Physiological, metabolic, and transcrip-tional effects of biologically-synthesized silver nanoparticles in turnip (Brassica rapa ssp. rapa L.). Protoplasma 252, 1031–1046.\nWeremczuk-Jezyna, I., Grzegorczyk-Karolak, I., Frydrych, B., Królicka, A., Wysokińska, H. (2013) Hairy roots of Dracocephalum moldavica: rosmarinic acid content and antioxidant potential. Acta Physiol. Plant. 35, 2095–2103.\nXing, B., Yang, D., Guo, W., Liang, Z., Yan, X., Zhu, Y., Liu, Y. (2015) Ag+ as a more effective elicitor for production of tanshinones than phenolic acids in Salvia miltiorrhiza hairy roots. Molecules 20, 309–324.\nYan, Q., Shi, M., Ng, J., Wu, J. Y. (2006) Elicitor-induced rosmarinic acid accumulation and secondary metabolism enzyme activities in Salvia miltiorrhiza hairy roots. Plant Sci. 170, 853–858.\nYoon, J. Y., Chung, I. M., Thiruvengadam, M. (2015) Evaluation of phenolic compounds, antioxidant and antimicrobial activities from transgenic hairy root cultures of gherkin (Cucumis anguria L.). S. Afr. J. Bot. 100, 80–86.\nZhang, B., Zheng, L. P., Li, Y. W., Wang, J. W. (2013) Stimulation of artemisinin production in Artemisia annua hairy roots by Ag-SiO2 core-shell nanoparticles. Curr. Nanosci. 9, 363–370.\nZhang, C. H., Yan, Q., Cheuk, W. K., Wu, J. Y. (2004) Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag+ elicitation and nutrient feeding. Planta Med. 70, 147–151.",{"EN":462},"The present study describes the elicitor effect of silver ion (Ag+) and biologically synthesized silver nanoparticles (AgNPs) to enhance the biomass accumulation and phenolic compound production as well as biological activities (antioxidant, antimicrobial and anticancer) in genetically transformed root (hairy root) cultures of Cucumis anguria. The biomass of hairy root cultures was signifcantly increased by AgNPs whereas decreased in Ag+ elicitation at 1 and 2 mg\u002FL. AgNPs-elicited hairy roots produced a signifcantly higher amount of individual phenolic compounds (favonols, hydroxycinnamic and hydroxybenzoic acids), total phenolic and favonoid contents than Ag+-elicited hairy roots. Moreover, antioxidant, antimicrobial and anticancer activities were signifcantly higher following AgNPs-elicitation compared with that in Ag+-elicited hairy roots. We suggest that AgNPs could be an effcient elicitor in hairy root cultures to increase the phytochemical production.",{"EN":464},"Effect of Silver Nanoparticles on Phenolic Compounds Production and Biological Activities in Hairy Root Cultures of Cucumis Anguria",{"VOID":466},"10.1556\u002F018.68.2018.1.8","https:\u002F\u002Fwww.akademiai.com\u002Fdoi\u002F10.1556\u002F018.68.2018.1.8",[469,484,496],{"id":470,"sortIndex":19,"researcher":18,"roles":471,"affiliations":472,"properties":481},"92c540a3-8b04-4e7a-87b7-16bf32941af6",[132],[473],{"id":18,"sortIndex":19,"affiliation":474,"properties":18},{"id":475,"createTime":476,"updateTime":476,"relativeEntities":477,"slug":18,"properties":478,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"79014634-2645-42ff-80cd-7c1b51f9a88b","2023-11-30T20:49:19.616+00:00",[],{"title":479},{"VI":480},"Department of Applied Bioscience, College of Life and 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(1956) Formulas and tables to facilitate the calculation of recombination values in heredity. Hilgardia 24, 235–278.\nBotstein, D., White, R. L., Skolnick, M., Davis, R. W. (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314–331.\nBoutin, S. R., Young, N. D., Lorenzen, L. L., Shoemaker, R. C. (1995) Marker-based pedigrees and graphical genotypes generated by supergene software. Crop Sci. 35, 1703–1707.\nCaetano-Annollés, G., Bassam, B. J., Gresshoff, P. (1993) Enhanced detection of polymorphic DNA by multiple arbitrary amplicon profiling of endonuclease-digested DNA: identification of markers tightly linked to the supernodulation locus in soybean. Mol. Gen. Genet. 241, 57–64.\nChaparro, A., Stomeyer III, C. F., Huand, E. P., Kronauer, R. E., Eskew, R. T. Jr. (1993) Color is what the eye sees best. Nature (London) 361, 348–362.\nKiss, G. B., Csanádi, G., Kálmán, K., Kaló, P., Ökrész, L. (1993) Construction of a basic genetic map for alfalfa using RFLP, RAPD, isozyme and morphological markers. Mol. Gen. Genet. 238, 129–137.\nLander, E. S., Green, P., Abrahamson, J., Barlow, A., Daly, M. J. (1987) MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1, 174–81.\nLincoln, S., Daly, M., Lander, E. (1992) Constructing genetic maps with MAPMAKER\u002FEXP 3.0. Whitehead Institute Technical Report, 3rd edition.\nMendel, G. (1866) Versuche über Pflanzen-Hybriden. Verhandlungen des naturforschenden Vereines in Brünn 4, 3–47.\nSouthern, E. M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503–517.\nSturtevant, A. H. (1913) The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association. J. Exp. Zool. 14, 203–204.\nVos, P., Hogers, R., Bleeker, M., Reijans, M., van de Lee, T., Homes, M., Frijters, A., Pot, J., Peleman, J., Kuiper, M., Zabeau, M. (1995) AFLP: a new technique for DNA fingerprinting. Nucl. Acids Res. 23, 4407–4417.\nWelsh, J., McClelland, M. (1990) Fingerprinting genomes using PCR with arbitrary primers. Nucleic Acids Res. 18, 7213–7218.\nWilliams, J. G. K., Kubelik, A. R., Livak, K. J., Rafalski, J. A., Tingey, S. (1990) DNA polymorphism amplified by arbitrary primers are useful as genetic markers. Nucleic Acids Res. 18, 6531–6535.\nYoung, N. D., Tanksley, S. D. (1989) Restriction fragment length polymorphism maps and the concept of graphical genotypes. Theor. Appl. Genet. 77, 95–101.",{"EN":749},"We describe a new procedure, called colormapping, a non-mathematical method for genetic mapping. Numerical scores representing the genotypes of the markers are converted to colors and these are used to display the genotypes of the markers for each individual in a segregating population. Color genotypes are arranged in a matrix where each row corresponds to a marker – ordered according to their position in the appropriate Linkage Group – and each column represents an individual in the mapping population. The picture is called colormap by which the genotypes of the chromosomal segments can be shown for each individual in the segregating population. A colormap can be used for whole genome analysis which is profitable in genetic and breeding experiments and is suitable for genetic mapping, too. The location of a new marker is found by recognizing similarities between the color pattern of the individuals for the new marker and the ordered markers in the colormap. Colormapping can also be used to find linkages which cannot be determined unambiguously by conventional mapping programs. 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Chem., 270, 2203, 10.1074\u002Fjbc.270.5.2203",{"doi":1129},"10.1074\u002Fjbc.270.5.2203",{"id":1131,"createTime":1132,"updateTime":1133,"relativeEntities":1134,"slug":1135,"properties":1136,"entityType":126,"verifyStatus":203,"verifyTime":1133,"verifyNote":204,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1145,"fullTextUrl":18,"authors":1146,"publicationType":159,"publisherRelationship":1162,"citationCount":18,"citationInfo":18,"publishDate":1187,"publishYear":1188,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":187},"0bfe3793-0c41-4e5c-975d-521d59dbd73a","2024-02-09T14:01:44.915+00:00","2025-01-07T23:46:20.916+00:00",[],"The-Effects-of-A-Wheat-Germ-Rich-Diet-on-Oxidative-Mtdna-Damage-mtDNA-copy-Number-and-Antioxidant-Enzyme-Activities-in-Aging-Drosophila",{"references":1137,"abstract":1139,"title":1141,"doi":1143},{"VOID":1138},"Adom, K. K., Sorrells, M. E., Liu, R. H. (2005) Phytochemicals and antioxidant activity of milled fractions of different wheat varieties. J. Agric. Food Chem. 53, 2297–2306.\nAlvarez, P., Alvarado, C., Puerto, M., Schlumberger, A., Jimenez, L., De la Fuente, M. (2006) Improvement of leucocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals. Nutritio. 22, 913–921.\nAmes, B. N., Shigenaga, M. K., Hagen, T. M. (1993) Oxidants, antioxidants and the degenerative diseases of aging. Natl Acad Sci. US. 90, 7915–7922.\nBarazzoni, R., Short, K. R., Nair, K. S. (2000) Effects of aging on mitochondrial DNAcopy number and cytochrome coxidase gene expression in rat skeletal muscle, liver and heart. J. Biol. Chem. 275, 3343–3347.\nChang, C. L., Vargas, R. I. (2007) Wheat germ oil and its effects on a liquid larval rearing diet for oriental fruit flies (diphtera:tephritidae). J. Econ. Entomol. 100, 322–326.\nCorral-Debrinski, M., Shoffner, J. M., Lott, M. T., Wallace, D. C. 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(2010) Effects of two important components related with mitochondria: CoQIO and acetyl 1 carnitine in antioxidant enzyme activities. Journal of Animal and Veterinary Advance. 9, 3109–3113.\nRodriguez, C., Mayo, J. C., Sainz, R. M., Antolin, I., Herrera, F., Martin, V., Reiter, R. J. (2004) Regulation of antioxidant enzymes: a significant role for melatonin. J. Pineal. Res. 36, 1–9.\nSantos, J. H., Mandavilli, B. S., Van Houten, B. (2002) Measuring oxidative mtDNA damage and repair using QPCR. In: Copeland, W. C. (ed.) Mitochondrial DNA Methods and Protocols. Humana Press Inc, Totawa NJ, pp. 159–176.\nTiana, L., Caib, Q., Wei, H. (1998) The activities of antioxidant enzymes in most tissues displayed an age dependent decline. Free Radic. Biol. Med. 24, 1477–1484.\nTu, C. P., Akgul, B. (2005) Drosophila glutathione S transferases. Methods Enzymol. 401, 204–226.\nVenkatraman, A., Landar, A., Davis, A. J., Chamlee, L., Sandersoni, T., Kim, H., Page, G., Pompilius, M., Ballinger, S., Darley-Usmar, V., Bailey, S. M. (2004) Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatoxicity. J. Biol. Chem. 279, 22092–22101.\nWang, Y., Liu, V. W., Xue, W. C., Tsang, P. C., Cheung, A. N., Ngan, H. Y. (2005) The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: a quantitative study using laser-captured microdissected tissues. Gynecol. Oncol. 98, 104–110.\nYakes, F. M., Van Houten, B. (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl Acad. Sci. US. 94, 514–519.",{"EN":1140},"The free radical theory of aging posits that the accumulation of macromolecular damage induced by toxic reactive oxygen species plays a central role in the aging process. Therefore consumption of dietary antioxidants appears to be of great importance. Wheat germ have strong antioxidant properties. Aim of this study is investigate the effects of a wheat germ rich diet on oxidative mtDNA damage, mtDNA copy number and antioxidant enzyme activities in Drosophila. Current results suggested that dietary wheat germ enhances the activities of antioxidant enzymes in Drosophila. There was no statistically difference in mtDNA damage and mtDNA copy number results of “Wheat Germ” and “Refined White Flour” feed groups. mtDNA damage slightly increased with aging in both groups but these changes were no statistically different.",{"EN":1142},"The Effects of A Wheat Germ Rich Diet on Oxidative Mtdna Damage, mtDNA copy Number and Antioxidant Enzyme Activities in Aging Drosophila",{"VOID":1144},"10.1556\u002FABiol.64.2013.1.1","https:\u002F\u002Fakjournals.com:443\u002Fview\u002Fjournals\u002F018\u002F64\u002F1\u002Farticle-p1.xml",[1147],{"id":1148,"sortIndex":19,"researcher":18,"roles":1149,"affiliations":1150,"properties":1159},"f1cf2dd4-bec5-4d23-b5a8-c4d1ae77348c",[132],[1151],{"id":18,"sortIndex":19,"affiliation":1152,"properties":18},{"id":1153,"createTime":1154,"updateTime":1154,"relativeEntities":1155,"slug":18,"properties":1156,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"e3294572-81b1-4960-92b6-0fb03a59f135","2024-02-09T14:01:44.933+00:00",[],{"title":1157},{"VI":1158},"Department of Biology, Mehmet Akif Ersoy University, Burdur, Turkey",{"title":1160},{"VI":1161},"Ayse Gul Mutlu",{"url":1145,"publisher":1163,"properties":1182},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1164,"slug":10,"properties":1165,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1168,"manageAffiliations":1169,"indexDatabases":1170,"url":18,"thumbnailPath":18,"statistic":1177,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":1166,"title":1167},{"VOID":13},{"EN":15},[],[],[1171],{"id":24,"indexDatabase":1172,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":1173,"label":1174,"description":1175,"key":34,"publicationTags":1176,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":19,"impactFactorByYear":1178,"i10Index":50,"i10IndexLast5Year":19,"totalPublication":51,"totalPublicationByYear":1179,"totalCitation":68,"totalCitationByYear":1180,"totalCitationPerPublication":83,"totalCitationPerPublicationByYear":1181,"hindexLast5Year":107,"hindex":107},{"2012":42,"2013":43,"2014":44,"2015":45,"2016":46,"2017":47,"2018":46,"2019":48,"2020":49},{"1997":53,"1998":54,"1999":55,"2000":53,"2001":55,"2002":56,"2003":57,"2004":58,"2005":58,"2006":56,"2007":59,"2008":60,"2009":61,"2010":50,"2011":62,"2012":63,"2013":58,"2014":64,"2015":57,"2016":65,"2017":66,"2018":58,"2019":67},{"1997":59,"1998":70,"1999":57,"2000":71,"2001":72,"2002":73,"2003":58,"2004":74,"2005":75,"2006":76,"2007":76,"2008":77,"2009":76,"2010":78,"2011":79,"2012":80,"2013":81,"2014":58,"2015":59,"2016":59,"2017":82,"2018":64},{"1997":85,"1998":86,"1999":87,"2000":88,"2001":89,"2002":90,"2003":91,"2004":92,"2005":93,"2006":94,"2007":95,"2008":96,"2009":97,"2010":98,"2011":99,"2012":100,"2013":101,"2014":102,"2015":103,"2016":104,"2017":105,"2018":106},{"volume":1183,"pages":1185},{"VOID":1184},"64",{"VOID":1186},"1-9","2013-12-30",2013,{"id":1190,"createTime":1191,"updateTime":1192,"relativeEntities":1193,"slug":1194,"properties":1195,"entityType":126,"verifyStatus":203,"verifyTime":1192,"verifyNote":204,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1204,"fullTextUrl":18,"authors":1205,"publicationType":159,"publisherRelationship":1221,"citationCount":18,"citationInfo":18,"publishDate":1246,"publishYear":991,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":187},"7d8cd182-fa12-46d4-825d-f06b7fbed057","2024-01-26T19:53:43.796+00:00","2024-10-10T23:45:55.454+00:00",[],"On-The-Micro-Space-Theory-of-Osmosis-Osmofiltration-active-Water-Flow-in-Membrane-Gaps",{"references":1196,"abstract":1198,"title":1200,"doi":1202},{"VOID":1197},"Berecz, E. 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(1966) Hindered diffusion along the membrane and water transport in a two-membrane system. Acta Biochim. Biophys. Acad. Sci. Hung. 5, 419–426.\nHomola, L. (1970) Water circulation caused by hindered diffusion and unequal distribution of solutes. Acta Biochim. Biophys. Acad. Sci. Hung. 5, 365–371.\nKatschalsky A., Kedem O. (1962) Thermodynamics of flow processes in biological system. Biophys. J. 2 (Suppl.), 53–78.\nLepeschkin, W. W. (1906) Beih. z. Bot. Zentralblatt 19, p. 409.\nLepeschkin, W. W. (1909) Beih. z. Bot. Zentralblatt 24, p. 308.\nLoeschke K., Bentzel C. J., Csáky, T. Z. (1970) Asymmetry of osmotic flow in frog intestine: functional and structural correlation. (Transepithelial osmotic flow asymmetry.) Am. J. Physiol. (USA). 218, 1723–1731.\nOrmai, S. (1993) Physiology-Pathophysiology. Semmelweis Kiado. Budapest. (In Hungarian)\nPocsik, I. (1964) A study on the temperature depedence of permeability. In: Bulletin II of Hungarian Biophysical Society. Pecsi Szikra Nyomda, p. 104.\nVető, F. (1964) Thermoosmosis on hen’s eggs. In: Bulletin II Hungarian Biophysical Society. Pécsi Szikra Nyomda, p. 105.",{"EN":1199},"The author revised the conclusion drawn from his former experiments and recognized a complex phenomenon that he named osmofiltration. This phenomenon occurs by way of the inhibition of the diffusion within a micro-gap bordering the experimental membrane in the model. It may have a significance as a basic biological phenomenon in similar biological membranous structures, and even, it may have a medical importance. The author discusses his working hypothesis about the micro-space theory of osmosis.",{"EN":1201},"On The Micro-Space Theory of Osmosis Osmofiltration, “active” Water-Flow in Membrane-Gaps",{"VOID":1203},"10.1556\u002FABiol.52.2001.1.12","https:\u002F\u002Fakjournals.com:443\u002Fview\u002Fjournals\u002F018\u002F52\u002F1\u002Farticle-p125.xml",[1206],{"id":1207,"sortIndex":19,"researcher":18,"roles":1208,"affiliations":1209,"properties":1218},"23c9b1c0-bc37-483f-8841-3b2150d6b8f6",[132],[1210],{"id":18,"sortIndex":19,"affiliation":1211,"properties":18},{"id":1212,"createTime":1213,"updateTime":1213,"relativeEntities":1214,"slug":18,"properties":1215,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"d3be2d6c-b84d-4be9-9187-7fdb41b6ded8","2024-01-26T19:53:43.808+00:00",[],{"title":1216},{"VI":1217},"Biophysical Institute and Dept. of Family Medicine, University of Pécs, Pécs, Hungary",{"title":1219},{"VI":1220},"L. 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Springer, New York, pp. 159–170.",{"EN":1257},"Enigmatic morphological features of the formation and fate of ‘dark’ (hyper-basophilic, hyper-argy-rophilic and hyper-electrondense) neurons suggest that the mechanical work causing their dramatic shrinkage (whole-cell ultrastructural compaction) is done by a previously ‘unknown’ ultrastructural component residing in the spaces between their ‘known’ (i.e. visible in the conventional transmission electron microscopy) ultrastructural constituents. Embedment-free section electron microscopy revealed in these spaces the existence of a continuous network of gel microdomains, which is embedded in a continuous network of fluid-filled lacunae. We gathered experimental facts suggesting that this gel network is capable of a volume-reducing phase-transition (an established physico-chemical phenomenon), which could be the motor of the whole-cell ultrastructural compaction. The present paper revisits our relevant observations and speculates how such a continuous whole-cell gel network can do both whole-cell and compartmentalized mechanical work.",{"EN":1259},"A Cytoplasmic Gel Network Capable of Mediating the Conversion of Chemical Energy to Mechanical Work in Diverse Cell Processes: A Speculation",{"VOID":1261},"10.1556\u002FABiol.61.2010.4.1","https:\u002F\u002Fakjournals.com:443\u002Fview\u002Fjournals\u002F018\u002F61\u002F4\u002Farticle-p367.xml",[1264],{"id":1265,"sortIndex":19,"researcher":18,"roles":1266,"affiliations":1267,"properties":1276},"21a3ee2f-1897-4193-a5d7-c110e6ffd50f",[132],[1268],{"id":18,"sortIndex":19,"affiliation":1269,"properties":18},{"id":1270,"createTime":1271,"updateTime":1271,"relativeEntities":1272,"slug":18,"properties":1273,"entityType":142,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"e3317b69-cdff-4d0e-a416-72f6bbb95253","2023-12-19T08:17:59.752+00:00",[],{"title":1274},{"VI":1275},"Department of Neurosurgery, Faculty of Medicine, University of Pécs, Pécs, Hungary",{"title":1277},{"VI":1278},"F. 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