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1983, Specific stimulation of human T lymphocytes by substance P, J Immunol, 131, 1613, 10.4049\u002Fjimmunol.131.4.1613\nPauwels, 1989, Interactions between neurotransmitters and inflammatory cells in the airways, Int Arch Allergy Appl Immunol, 88, 68, 10.1159\u002F000234751\nCummins, 1989, Separate effects of irradiation and of graft-versus-host reaction on rat mucosal mast cells, Gut, 30, 355, 10.1136\u002Fgut.30.3.355\nZheng, 2000, Role of mast cells in early and delayed radiation injury in rat intestine, Radiat Res, 153, 533, 10.1667\u002F0033-7587(2000)153[0533:ROMCIE]2.0.CO;2\nAalto, 1998, Is radiation-induced degranulation of mast cells in salivary glands induced by substance P?, Oral Oncol, 34, 332, 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10.1016\u002F0031-9384(95)02067-5\nYoung, 1995, Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin, Diabetologia, 38, 642, 10.1007\u002FBF00401833\nGedulin, 1997, Dose-response for glucagonostatic effect of amylin in rats, Metabolism, 46, 67, 10.1016\u002FS0026-0495(97)90170-0\nYoung, 1997, Amylin's physiology and its role in diabetes, Curr Opin Endocrinol Diabetes, 4, 282, 10.1097\u002F00060793-199708000-00006\nYoung, 1998, Roles of amylin in diabetes and in regulation of nutrient load, Nutrition, 14, 524\nGedulin, 1998, Amylin inhibits lipase and amylase secretion from the exocrine pancreas in rats, Diabetes, 47, A280\nYoung, 2000, Chapter 9: neuroendocrine actions of amylin, 91\nKashimura, 1993, The stimulatory effects and binding characteristics of PACAP27 in rat dispersed pancreatic acini, Tohoku J Exp Med, 171, 243, 10.1620\u002Ftjem.171.243\nSchmidt, 1993, PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP\u002FPACAP-2 receptors: additive augmentation of CCK\u002Fcarbachol-induced enzyme release, Pancreas, 8, 476, 10.1097\u002F00006676-199307000-00012\nRaufman, 1991, PACAP-38, a novel peptide from ovine hypothalamus, is a potent modulator of amylase release from dispersed acini from rat pancreas, Regul Pept, 36, 121, 10.1016\u002F0167-0115(91)90200-Z\nBarnhart, 1997, PACAP-38 causes phospholipase C-dependent calcium signaling in rat acinar cell line, Surgery, 122, 465, 10.1016\u002FS0039-6060(97)90040-4\nPittner, 1989, Exposure of cultured hepatocytes to cyclic AMP enhances the vasopressin-mediated stimulation of inositol phosphate production, Biochem J, 257, 455, 10.1042\u002Fbj2570455\nPitchford, 1995, Nerve growth factor stimulates rapid metabolic responses in PC12 cells, Am J Physiol, 268, C936, 10.1152\u002Fajpcell.1995.268.4.C936\nOwicki, 1990, Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells, Proc Natl Acad Sci U S A, 87, 4007, 10.1073\u002Fpnas.87.10.4007\nParce, 1990, Biosensors for directly measuring cell affecting agents, Ann Biol Clin (Paris), 48, 639\nAmsterdam, 1974, Studies on dispersed pancreatic exocrine cells: I. Dissociation technique and morphologic characteristics of separated cells, J Cell Biol, 63, 1037, 10.1083\u002Fjcb.63.3.1037\nGardner, 1977, Regulation of amylase release from dispersed pancreatic acinar cells, J Physiol (Lond), 270, 439, 10.1113\u002Fjphysiol.1977.sp011961\nWarzecha, 1997, Protective effect of calcitonin gene-related peptide against caerulein-induced pancreatitis in rats, J Physiol Pharmacol, 48, 775\nYoung, 1996, Preclinical pharmacology of pramlintide in the rat: comparisons with human and rat amylin, Drug Dev Res, 37, 231, 10.1002\u002F(SICI)1098-2299(199604)37:4\u003C231::AID-DDR5>3.0.CO;2-M\nPieber, 1994, Direct plasma radioimmunoassay for rat amylin-(1–37): concentrations with acquired and genetic obesity, Am J Physiol, 267, E156\nWeber, 1998, Relationships between gastric emptying and intestinal absorption of nutrients and energy in mini pigs, Dig Dis Sci, 43, 1141, 10.1023\u002FA:1018874800819\nSpannagel, 1996, Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion, Proc Natl Acad Sci U S A, 93, 4415, 10.1073\u002Fpnas.93.9.4415\nDenaro, 1998, Gastrointestinal effects of pramlintide, Diabetologia, 41, A184\nHollander, 2003, Addition of pramlintide to insulin therapy lowers HbA1c in conjunction with weight loss in patients with type 2 diabetes approaching glycaemic targets, Diabetes Obes Metab, 5, 408, 10.1046\u002Fj.1463-1326.2003.00295.x\nRatner, 2004, Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year randomized controlled trial, Diabet Med, 21, 1204, 10.1111\u002Fj.1464-5491.2004.01319.x\nWhitehouse, 2002, A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes, Diabetes Care, 25, 724, 10.2337\u002Fdiacare.25.4.724\nBalfour, 1993, Acarbose: an update of its pharmacology and therapeutic use in 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CCK—pancreozymin, caerulein, or calcium—no response to vagal stimulation, Gut, 18, 615, 10.1136\u002Fgut.18.8.615\nFunovics, 1981, The effect of SST, glucagon, calcitonin and PGE1 on exocrine pancreatic secretion in the unrestrained dog in long-term experiments, Eur Surg Res, 13, 213, 10.1159\u002F000128187\nPaul, 1975, Intraindividually controlled studies in man on the inhibition of exocrine pancreas secretion using salmon calcitonin, Verh Dtsch Ges Inn Med, 81, 1266\nBeaumont, 1993, High affinity amylin binding sites in rat brain, Mol Pharmacol, 44, 493\nSilvestre, 2001, Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas, Am J Physiol, 280, E443\nJodka, 1996, Amylin modulation of gastric emptying in rats depends upon an intact vagus nerve, Diabetes, 45, 235A\nEdwards, 1998, Area postrema (AP)-lesions block the regulation of gastric emptying by amylin, Neurogastroenterol Motil, 10, 26\nGreenberger, 1991, Ch 260: acute and chronic 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J. Pharmacol., 60, 1149, 10.1139\u002Fy82-166\nNeedleman, 1986, Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte and blood pressure homeostatis, N. Engl. J. Med., 314, 828, 10.1056\u002FNEJM198603273141306\nWinquist, 1984, Vasodilator profile of synthetic atrial natriuretic factor, Eur. J. Pharmacol., 102, 169, 10.1016\u002F0014-2999(84)90353-4\nTrippodo, 1986, Biologic mechanisms of atrial natriuretic factor, J. Lab. Clin. Med., 109, 112\nCuneo, 1986, Renal, hemodynamic, and hormonal responses to atrial natriuretic peptide infusion in man, and effect of sodium intake, J. Clin. End. Metabol., 65, 946, 10.1210\u002Fjcem-63-4-946\nBussien, 1986, Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers, J. Cardiovasc. Pharmacol., 8, 216, 10.1097\u002F00005344-198601000-00031\nRichards, 1985, Renal, haemodynamic, and hormonal effects of alpha atrial natriuretic peptide in healthy volunteers, Lancet, i, 545, 10.1016\u002FS0140-6736(85)91207-3\nBreuhaus, 1985, Atriopeptin II lowers cardiac output in conscious sheep, Am. J. Physiol., 249, R776\nBie, 1988, Hemodynamic and renal effects of low-dose infusion of atrial peptide in awake dogs, Am. J. Physiol., 254, R161\nAnderson, 1986, Plasma release of atrial natriuretic peptide in response to blood volume expansion, J. Endocrinol., 109, 9, 10.1677\u002Fjoe.0.1090009\nAnderson, 1986, The plasma release of atrial natriuretic peptide in man, Clin. Sci., 71, 151, 10.1042\u002Fcs0710151\nPetterson, 1988, Haemodynamics and plasma ANP (atrial natriuretic peptide) after acute blood volume expansion in normotensive and spontaneously hypertensive rats, Acta Physiol. Scand., 133, 513, 10.1111\u002Fj.1748-1716.1988.tb08435.x\nØie, 1989, Atrial natriuretic peptide from the coronary sinus is acutely increased following induction of paroxysmal tachycardia, J. Am. Coll. Cardiol., 13, 172 A\nGoetz, 1988, Physiology and pathophysiology of atrial peptides, Am. J. Physiol., 254, E1\nFaison, 1985, Regional vasorelaxant selectivity of atrial natriuretic factor in isolated rabbit vessels, Life Sci., 37, 1073, 10.1016\u002F0024-3205(85)90599-5\nIshikawa, 1987, Heterogenety in vasorelaxant effects of α-human atrial natriuretic polypeptide in the dog, Jpn. J. Pharmacol., 44, 515, 10.1254\u002Fjjp.44.515\nJansen, 1987, A comparison of the vasodilator responses to atrial peptides in the pulmonary and renal arteries of the pig in vitro, Br. J. Pharmacol., 91, 687, 10.1111\u002Fj.1476-5381.1987.tb11263.x\nCohen, 1985, Atriopeptin II: Differential sensitivity of arteries and veins from the rat, Eur. J. Pharmacol., 108, 103, 10.1016\u002F0014-2999(85)90288-2\nWinquist, 1984, Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle, 81, 7661\nIgnarro, 1986, Atriopeptin II relaxes and elevates cGMP in bovine pulmonary artery but not vein, J. Appl. Physiol., 60, 1128, 10.1152\u002Fjappl.1986.60.4.1128\nRapoport, 1986, Effects of atriopeptine on relaxation and cyclic GMP levels in rat and rabbit aortas, Eur. J. Pharmacol., 120, 123, 10.1016\u002F0014-2999(86)90651-5\nOhlstein, 1985, Cyclic guanosine monophosphate mediates vascular relaxation induced by atrial natriuretic factor, Hypertension, 7, 306, 10.1161\u002F01.HYP.7.2.306\nMulvany, 1988, Vascular actions of atrial natriuretic peptide, Pharmacol. Res. Commun., 20, 23, 10.1016\u002FS0031-6989(88)80104-8\nTaylor, 1986, The inhibitory effects of a synthetic atrial peptide on contractions and Ca fluxes in vascular smooth muscle, J. Pharmacol. Exp. Ther., 237, 803\nMeisheri, 1986, Synthetic atrial peptide inhibits intracellular calcium release in smooth muscle, Am. J. Physiol., 250, C171, 10.1152\u002Fajpcell.1986.250.1.C171\nVulliemoz, 1980, Effect of benzothiadiazine derivatives on cyclic nucleotide phosphodiesterase and on the tension of the aortic strip, Blood Vessels, 17, 91\nWeishaar, 1987, Multiple molecular forms of phosphodiesterase: an overview, Protein Phosphorylation Res., 11, 463\nCurrie, 1984, Atriopeptin release from the isolated perfused rabbit heart, Biochem Biophys. Res. Commun., 124, 711, 10.1016\u002F0006-291X(84)91016-7\nLang, 1985, Atrial natriuretic factor, a circulating hormone stimulated by volume loading, Nature, 314, 246, 10.1038\u002F314264a0\nAardal, 1989, Atriopeptin modulations of adrenoceptor responses in the pulmonary artery and ascending aorta in the rat\nFurchgott, 1980, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, 228, 373, 10.1038\u002F288373a0\nHøgestatt, 1983, Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording mechanical activity in isolated small blood vessels, Acta Physiol. Scand., 117, 49, 10.1111\u002Fj.1748-1716.1983.tb07178.x\nBråtveit, 1987, Comparison of atriopeptins II and III, VIP and β2-adrenoceptor-evoked relaxations in the two layers of smooth muscle in the rat portal vein, Acta Physiol. 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Pharmacol., 115, 219, 10.1016\u002F0014-2999(85)90694-6\nKubota, 1985, Calcitonin gene-related peptide stimulates cyclic AMP formation in rat aortic smooth muscle cells, Biochem. Biophys. Res. Commun., 132, 88, 10.1016\u002F0006-291X(85)90992-1\nWilson, 1988, Vasoactive intestinal peptide elevates cyclic AMP levels and potentiates secretion in bovine adrenal chromaffin cells, Neuropeptides, 11, 17, 10.1016\u002F0143-4179(88)90023-6\nAmenta, 1988, Vasoactive intestinal polypeptide-sensitive cyclic adenosine monophosphate generating system in the rat portal vein, Arch. Int. Pharmacodyn., 291, 88\nDevine, 1972, Sarcoplasmic reticulum and exitation-concentration coupling in mammalian smooth muscle, J. Cell. Biol., 52, 690, 10.1083\u002Fjcb.52.3.690\nLappe, 1985, Failure of atriopeptin II to cause arterial vasodilation in the conscious rat, Circ. 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Pept., 70, 121, 10.1016\u002FS0167-0115(97)00021-9\nDeftos, 1990, A chromogranin A-derived peptide differentially regulates the secretion of calcitonin gene products, J. Bone Miner. Res., 5, 989, 10.1002\u002Fjbmr.5650050913\nMetz-Boutigue, 1998, Antibacterial peptides are present in chromaffin cell secretory granules, Cell. Mol. Neurobiol., 18, 249, 10.1023\u002FA:1022573004910\nMcVicar, 2001, Analysis of the post-translational processing of chromogranin A in rat neuroendocrine tissue employing a N-terminal site-specific antiserum, J. Neuroendocrinol., 13, 588, 10.1046\u002Fj.1365-2826.2001.00671.x\nWaynforth, 1992, Ch7 vital statistics and miscellaneous information, 341\nWeihe, WH. Ch.19 the laboratory rat. In: Poole, T. (Ed.). The UFAH handbook on the care and management of laboratory animals. 6th ed. Longman, Livingstone, New York, 1987: p. 309–330.\nJohnston, 1986, Neuroendocrine cells within colorectal tumours induced by dimethylhydrazine—an immunocytochemical study, Cell Tissue Res., 246, 205, 10.1007\u002FBF00219019\nCunningham, 1996, Development of a radioimmunoassay to a fragment of vasostatin II, Biochem. Soc. Trans., 24, 304s, 10.1042\u002Fbst024304s\nNorlén, 2001, Cell specific processing of chromogranin A in endocrine cells of the rat stomach, J. Histochem. Cytochem., 49, 9, 10.1177\u002F002215540104900102\nBarkatullah, 2001, Immunohistochemical localization of WE-14 in the developing porcine sympathoadrenal cell lineage, Histochem. Cell Biol., 116, 255, 10.1007\u002Fs004180100315\nCohn, 1984, Selective localization of the parathyroid secretory protein-I adrenal medulla CgA protein family in a wide variety of endocrine cells of the rat, Endocrinology, 114, 1963, 10.1210\u002Fendo-114-6-1963\nLloyd, 1992, Chromogranin A, chromogranin B and secretogranin II mRNAs in the pituitary and adrenal glands of various mammals. Regulation of chromgranin A, chromogranin B and secretogranin II mRNA levels by estrogen, Lab. Invest., 67, 394\nJeziorowski, 1997, Heterogeneity of pituitary gonadotrope cells in male rats, Arch. Histol. Cytol., 60, 355, 10.1679\u002Faohc.60.355\nDada, 1983, A quantitative immunocytochemical study of the luteinizing hormone and follicle-stimulating hormone cells in the adenohypophysis of adult male rats and adult female rats throughout the estrous cycle, Endocrinology, 113, 970, 10.1210\u002Fendo-113-3-970\nMartini, 1968, Neural control of anterior pituitary functions, Recent. Prog. Horm. Res., 24, 439\nMuller, 1998, Immunocytochemical localization of the prohormone convertases PC1 and PC2 in rat prolactin cells, J. Histochem. Cytochem., 46, 101, 10.1177\u002F002215549804600113\nUehara, 2001, Differential localization of prohormone convertases PC1 and PC2 in two distinct types of secretory granules in rat pituitary gonadotrophs, Cell Tissue Res., 304, 43, 10.1007\u002Fs004410100364\nHelle, 2000, The chromogranins. Historical perspectives, Adv. Exp. Med. Biol., 482, 3, 10.1007\u002F0-306-46837-9_1\nKim, 2000, Chromogranin A, an “on\u002Foff” switch controlling dense-core secretory granule biogenesis, Cell, 106, 499, 10.1016\u002FS0092-8674(01)00459-7\nHeaney, 2000, Immunocytochemical evaluation of the post-translational processing of chromogranin A in human pituitary adenomas, Pituitary, 3, 67, 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of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle",{"VOID":1827},"[\"18027059202862494258\"]",{"VOID":1829},"Zawilska, 2009, Physiology and pharmacology of melatonin in relation to biological rhythms, Pharmacol Rep, 61, 383, 10.1016\u002FS1734-1140(09)70081-7\nRaikhlin, 1976, Melatonin and enterochromaffine cells, Acta Histochem, 55, 19, 10.1016\u002FS0065-1281(76)80092-X\nRaikhlin, 1975, Melatonin may be synthesised in enterochromaffin cells, Nature, 255, 344, 10.1038\u002F255344a0\nKvetnoy, 2002, Gastrointestinal melatonin: cellular identification and biological role, Neuro Endocrinol Lett, 23, 121\nBubenik, 1999, Melatonin concentrations in the luminal fluid, mucosa, and muscularis of the bovine and porcine gastrointestinal tract, J Pineal Res, 26, 56, 10.1111\u002Fj.1600-079X.1999.tb00567.x\nLee, 1993, Melatonin and its receptors in the gastrointestinal tract, Biol Signals, 2, 181, 10.1159\u002F000109491\nChen, 2007, Distribution, function and physiological role of melatonin in the lower gut, World J Gastroenterol, 17, 3888, 10.3748\u002Fwjg.v17.i34.3888\nThor, 2007, Melatonin and serotonin effects on gastrointestinal motility, J Physiol Pharmacol, 58, 97\nTeresa Martin, 2005, Melatonin as a modulator of the ileal brake mechanism, Scand J Gastroenterol, 40, 559, 10.1080\u002F00365520510012316\nMartin, 1998, Melatonin and the gastrointestinal tract, Therapie, 53, 453\nReppert, 1997, Melatonin receptors: molecular biology of a new family of G protein-coupled receptors, J Biol Rhythms, 12, 528, 10.1177\u002F074873049701200606\nReppert, 1995, Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor, Proc Natl Acad Sci USA, 92, 8734, 10.1073\u002Fpnas.92.19.8734\nReppert, 1994, Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses, Neuron, 13, 1177, 10.1016\u002F0896-6273(94)90055-8\nDubocovich, 2005, Functional MT1 and MT2 melatonin receptors in mammals, Endocrine, 27, 101, 10.1385\u002FENDO:27:2:101\nvon Gall, 2002, Mammalian melatonin receptors: molecular biology and signal transduction, Cell Tissue Res, 309, 151, 10.1007\u002Fs00441-002-0581-4\nDrago, 2002, Small doses of melatonin increase intestinal motility in rats, Dig Dis Sci, 47, 1969, 10.1023\u002FA:1019696006677\nKasimay, 2005, Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors, J Physiol Pharmacol, 56, 543\nStorr, 2000, Inhibition of small conductance K+-channels attenuated melatonin-induced relaxation of serotonin-contracted rat gastric fundus, Can J Physiol Pharmacol, 78, 799, 10.1139\u002Fy00-059\nStorr, 2002, Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro, J Pineal Res, 33, 101, 10.1034\u002Fj.1600-079X.2002.02909.x\nMerle, 2000, Effect of melatonin 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Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats, Br J Pharmacol, 127, 987, 10.1038\u002Fsj.bjp.0702612\nFisher, 2009, Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat, Neurosci Lett, 457, 93, 10.1016\u002Fj.neulet.2009.04.005\nDortch-Carnes, 2012, Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells, Exp Eye Res, 107, 1, 10.1016\u002Fj.exer.2012.11.007\nMurthy, 2006, Signaling for contraction and relaxation in smooth muscle of the gut, Annu Rev Physiol, 68, 345, 10.1146\u002Fannurev.physiol.68.040504.094707\nMurthy, 1995, Adenosine A1 receptor-mediated activation of phospholipase C-beta 3 in intestinal muscle:dual requirement for alpha and beta gamma subunits of Gi3, Mol Pharmacol, 47, 1172\nDubocovich, 2010, International Union of Basic and Clinical Pharmacology. LXXV. 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