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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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J Natl Cancer Inst 1995, 87: 19-27. 10.1093\u002Fjnci\u002F87.1.19",{"doi":3552},"10.1093\u002Fjnci\u002F87.1.19",{"id":26,"text":3554,"url":26,"identifiers":3555},"Fowble BL, Schultz DJ, Overmoyer B, et al.: The influence of young age on outcome in early stage breast cancer. Int J Radiat Oncol Biol Phys 1994, 30: 23-33.",{"doi":3556},"10.1016\u002F0360-3016(94)90515-0",{"id":26,"text":3558,"url":26,"identifiers":3559},"Rubino C, de Vathaire F, Shamsaldin A, et al.: Radiation dose, chemotherapy, hormonal treatment and risk of second cancer after breast cancer treatment. Br J Cancer 2003, 89: 840-846. 10.1038\u002Fsj.bjc.6601138",{"doi":3560},"10.1038\u002Fsj.bjc.6601138",{"id":26,"text":3562,"url":26,"identifiers":3563},"Delia D, Goi K, Mizutani S, et al.: Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations. Oncogene 1997, 14: 2137-2147. 10.1038\u002Fsj.onc.1201050",{"doi":3564},"10.1038\u002Fsj.onc.1201050",{"id":26,"text":3566,"url":26,"identifiers":3567},"Mitchel RE, Jackson JS, Carlisle SM: Upper dose thresholds for radiation-induced adaptive response against cancer in high-dose-exposed, cancer-prone, radiation-sensitive Trp53 heterozygous mice. Radiat Res 2004, 162: 20-30. 10.1667\u002FRR3190",{"doi":3568},"10.1667\u002FRR3190",{"id":26,"text":3570,"url":26,"identifiers":3571},"Tinat J, Bougeard G, Baert-Desurmont S, et al.: 2009 version of the Chompret criteria for Li Fraumeni syndrome. J Clin Oncol 2009, 27: e108-109. author reply e110 10.1200\u002FJCO.2009.22.7967",{"doi":3572},"10.1200\u002FJCO.2009.22.7967",{"id":3574,"createTime":3575,"updateTime":3576,"relativeEntities":3577,"slug":3578,"properties":3579,"entityType":829,"verifyStatus":25,"verifyTime":3576,"verifyNote":830,"syncStatus":28,"languages":3595,"translateLanguages":26,"viewCount":36,"primaryUrl":3596,"fullTextUrl":26,"authors":3597,"publicationType":918,"publisherRelationship":3856,"citationCount":763,"citationInfo":3884,"publishDate":3886,"publishYear":3887,"citationAnalyzeStatus":3465,"lastCitationAnalyze":3888,"indexDatabases":26,"openAccess":26,"references":3889,"isForceReanalyzing":1256},"82074362-94fe-47a0-9ee0-89195ce0ffc1","2024-04-13T20:33:33.895+00:00","2025-01-20T12:59:23.281+00:00",[],"High-dose-stereotactic-body-radiotherapy-correlates-increased-local-control-and-overall-survival-in-patients-with-inoperable-hepatocellular-carcinoma",{"mag":3580,"keywords":3582,"pmc":3583,"openalex":3585,"abstract":3587,"title":3589,"pm":3591,"doi":3593},{"VOID":3581},"2131219951",{},{"VOID":3584},"4231524",{"VOID":3586},"W2131219951",{"EN":3588},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Recent studies using stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) have reported high tumor response and local control. However, the optimal SBRT dose remains unknown, and it is still not clear whether a dose response relationship for local control (LC) and overall survival (OS) exist or not. We performed this study to determine whether a dose response relationship for LC and OS is observed in SBRT for inoperable HCC.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods\u003C\u002Fjats:title>\n            \u003Cjats:p>Between 2003 and 2011, 108 patients with HCC were treated with SBRT. All patients were unsuitable for surgery or local ablation and had incomplete response to transarterial chemoembolization. Eighty-two patients with a longest tumor diameter (LD) less than or equal to 7.0 cm who were treated with 3-fraction SBRT and were analyzed. This cohort comprised 74 Child-Turcotte-Pugh (CTP) class A patients and 8 CTP class B7 patients. The median LD was 3.0 cm (range, 1.0–7.0 cm), and the median dose was 51 Gy (range, 33–60 Gy).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>LC and OS rates at 2 years after SBRT were 87% and 63%, respectively, with a median follow-up duration of 30 months for all patients. The 2-year LC\u002FOS rates for patients treated with doses of &gt; 54, 45–54, and &lt; 45 Gy were 100\u002F71, 78\u002F64, and 64%\u002F30%, respectively (p = .009\u002Fp &lt; .001). Multivariate analysis revealed that the SBRT dose (p = .005) and Barcelona Clinic Liver Cancer stage (p = .015) were significant prognostic factors for OS. Correlation analysis revealed a positive linear relationship between the SBRT dose and LC (p = .006, R = .899)\u002FOS (p = .002, R = .940) at 2 years. Based on the tumor-control probability model, a dose of 54.8 Gy provides 2-year LC with a 90% probability. Five patients experienced grade 3 or higher gastrointestinal toxicity, and 6 had deteriorating of CTP score by greater than or equal to 2 within 3 months of SBRT.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n            \u003Cjats:p>This study demonstrated a dose response relationship for LC and OS with SBRT for HCC. Higher LC rates resulting from an increased dose may translate into survival benefits for patients with HCC.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":3590},"High-dose stereotactic body radiotherapy correlates increased local control and overall survival in patients with inoperable hepatocellular 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Inclusion of organ deformation in dose calculations. Med Phys. 2003;30(3):290–5.",{"doi":4626},"10.1118\u002F1.1539039",{"id":26,"text":4628,"url":26,"identifiers":4629},"Dawson LA, Balter JM. Interventions to reduce organ motion effects in radiation delivery. Semin Radiat Oncol. 2004;14(1):76–80.",{"doi":4630},"10.1053\u002Fj.semradonc.2003.10.010",{"id":26,"text":4632,"url":26,"identifiers":4633},"Dawson LA, Brock KK, Kazanjian S, Fitch D, McGinn CJ, Lawrence TS, et al. The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy. Int J Radiat Oncol Biol Phys. 2001;51(5):1410–21.",{"doi":4634},"10.1016\u002FS0360-3016(01)02653-0",{"id":26,"text":4636,"url":26,"identifiers":4637},"Hara W, Soltys SG, Gibbs IC. CyberKnife robotic radiosurgery system for tumor treatment. Expert Rev Anticancer Ther. 2007;7(11):1507–15.",{"doi":4638},"10.1586\u002F14737140.7.11.1507",{"id":26,"text":4640,"url":26,"identifiers":4641},"Rosu M, Dawson LA, Balter JM, McShan DL, Lawrence TS, Ten Haken RK. Alterations in normal liver doses due to organ motion. Int J Radiat Oncol Biol Phys. 2003;57(5):1472–9.",{"doi":4642},"10.1016\u002Fj.ijrobp.2003.08.025",{"id":26,"text":4644,"url":26,"identifiers":4645},"Goodman KA, Wiegner EA, Maturen KE, Zhang Z, Mo Q, Yang G, et al. Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies. Int J Radiat Oncol Biol Phys. 2010;78(2):486–93.",{"doi":4646},"10.1016\u002Fj.ijrobp.2009.08.020",{"id":26,"text":4648,"url":26,"identifiers":4649},"Blomgren H, Lax I, Näslund I, Svanström R. Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol Stockh Swed. 1995;34(6):861–70.",{"doi":3964},{"id":26,"text":4651,"url":26,"identifiers":4652},"Herfarth KK, Debus J, Lohr F, Bahner ML, Rhein B, Fritz P, et al. Stereotactic single-dose radiation therapy of liver tumors: results of a phase I\u002FII trial. J Clin Oncol Off J Am Soc Clin Oncol. 2001s;19(1):164–70.",{"doi":4653},"10.1200\u002FJCO.2001.19.1.164",{"id":26,"text":4655,"url":26,"identifiers":4656},"Hoyer M, Roed H, Traberg Hansen A, Ohlhuis L, Petersen J, Nellemann H, et al. Phase II study on stereotactic body radiotherapy of colorectal metastases. Acta Oncol Stockh Swed. 2006;45(7):823–30.",{"doi":4657},"10.1080\u002F02841860600904854",{"id":26,"text":4659,"url":26,"identifiers":4660},"Méndez Romero A, Wunderink W, Hussain SM, De Pooter JA, Heijmen BJM, Nowak PCJM, et al. Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase i-ii study. Acta Oncol Stockh Swed. 2006;45(7):831–7.",{"doi":4661},"10.1080\u002F02841860600897934",{"id":26,"text":4663,"url":26,"identifiers":4664},"Schefter TE, Kavanagh BD, Timmerman RD, Cardenes HR, Baron A, Gaspar LE. A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases. Int J Radiat Oncol Biol Phys. 2005;62(5):1371–8.",{"doi":4665},"10.1016\u002Fj.ijrobp.2005.01.002",{"id":26,"text":4667,"url":26,"identifiers":4668},"Rusthoven KE, Kavanagh BD, Cardenes H, Stieber VW, Burri SH, Feigenberg SJ, et al. Multi-institutional phase I\u002FII trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol. 2009;27(10):1572–8.",{"doi":3952},{"id":26,"text":4670,"url":26,"identifiers":4671},"Lee MT, Kim JJ, Dinniwell R, Brierley J, Lockwood G, Wong R, et al. Phase I study of individualized stereotactic body radiotherapy of liver metastases. J Clin Oncol. 2009;27(10):1585–91.",{"doi":4672},"10.1200\u002FJCO.2008.20.0600",{"id":26,"text":4674,"url":26,"identifiers":4675},"Rule W, Timmerman R, Tong L, Abdulrahman R, Meyer J, Boike T, et al. Phase I dose-escalation study of stereotactic body radiotherapy in patients with hepatic metastases. Ann Surg Oncol. 2011;18(4):1081–7.",{"doi":4676},"10.1245\u002Fs10434-010-1405-5",{"id":26,"text":4678,"url":26,"identifiers":4679},"Meyer JJ, Foster RD, Lev-Cohain N, Yokoo T, Dong Y, Schwarz RE, et al. A phase I dose-escalation trial of single-fraction stereotactic radiation therapy for liver metastases. Ann Surg Oncol. 2016;23(1):218–24.",{"doi":4680},"10.1245\u002Fs10434-015-4579-z",{"id":26,"text":4682,"url":26,"identifiers":4683},"Davis JN, Medbery C, Sharma S, Perry D, Pablo J, D’Ambrosio DJ, et al. Stereotactic body radiotherapy for early-stage non-small cell lung cancer: clinical outcomes from a National Patient Registry. J Radiat Oncol. 2015;4(1):55–63.",{"doi":4684},"10.1007\u002Fs13566-014-0177-0",{"id":26,"text":4686,"url":26,"identifiers":4687},"Davis JN, Medbery C, Sharma S, Pablo J, Kimsey F, Perry D, et al. Stereotactic body radiotherapy for centrally located early-stage non-small cell lung cancer or lung metastases from the RSSearch(®) patient registry. Radiat Oncol Lond Engl. 2015;10:113.",{"doi":4688},"10.1186\u002Fs13014-015-0417-5",{"id":26,"text":4690,"url":26,"identifiers":4691},"Ricco A, Davis J, Rate W, Yang J, Perry D, Pablo J, et al. Lung metastases treated with stereotactic body radiotherapy: the RSSearch® patient Registry’s experience. Radiat Oncol Lond Engl. 2017;12(1):35.",{"doi":4692},"10.1186\u002Fs13014-017-0773-4",{"id":26,"text":4694,"url":26,"identifiers":4695},"Davis JN, Medbery C, Sharma S, Danish A, Mahadevan A. The RSSearch™ registry: patterns of care and outcomes research on patients treated with stereotactic radiosurgery and stereotactic body radiotherapy. Radiat Oncol Lond Engl. 2013;8:275.",{"doi":4696},"10.1186\u002F1748-717X-8-275",{"id":26,"text":4698,"url":26,"identifiers":4699},"Katz AW, Carey-Sampson M, Muhs AG, Milano MT, Schell MC, Okunieff P. Hypofractionated stereotactic body radiation therapy (SBRT) for limited hepatic metastases. Int J Radiat Oncol. 2007;67(3):793–8.",{"doi":4700},"10.1016\u002Fj.ijrobp.2006.10.025",{"id":26,"text":4702,"url":26,"identifiers":4703},"Ambrosino G, Polistina F, Costantin G, Francescon P, Guglielmi R, Zanco P, et al. Image-guided robotic stereotactic radiosurgery for unresectable liver metastases: preliminary results. Anticancer Res. 2009;29(8):3381–4.",{},{"id":26,"text":4705,"url":26,"identifiers":4706},"Scorsetti M, Arcangeli S, Tozzi A, Comito T, Alongi F, Navarria P, et al. Is stereotactic body radiation therapy an attractive option for unresectable liver metastases? A preliminary report from a phase 2 trial. Int J Radiat Oncol Biol Phys. 2013;86(2):336–42.",{"doi":4707},"10.1016\u002Fj.ijrobp.2012.12.021",{"id":26,"text":4709,"url":26,"identifiers":4710},"Chang DT, Swaminath A, Kozak M, Weintraub J, Koong AC, Kim J, et al. Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis. Cancer. 2011;117(17):4060–9.",{"doi":4711},"10.1002\u002Fcncr.25997",{"id":26,"text":4713,"url":26,"identifiers":4714},"Lee MT, Kim JJ, Dinniwell R, Brierley J, Lockwood G, Wong R, et al. Phase I study of individualized stereotactic body radiotherapy of liver metastases. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(10):1585–91.",{"doi":4672},{"id":26,"text":4716,"url":26,"identifiers":4717},"Katsoulakis E, Riaz N, Cannon DM, Goodman K, Spratt DE, Lovelock M, et al. Image-guided radiation therapy for liver tumors: gastrointestinal histology matters. Am J Clin Oncol. 2014;37(6):561–7.",{"doi":4718},"10.1097\u002FCOC.0b013e318282a86b",{"id":26,"text":4720,"url":26,"identifiers":4721},"Klement RJ, Guckenberger M, Alheid H, Allgäuer M, Becker G, Blanck O, et al. Stereotactic body radiotherapy for oligo-metastatic liver disease - influence of pre-treatment chemotherapy and histology on local tumor control. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2017;123(2):227–33.",{"doi":4722},"10.1016\u002Fj.radonc.2017.01.013",{"id":26,"text":4724,"url":26,"identifiers":4725},"Dieterich S, Gibbs IC. The CyberKnife in clinical use: current roles, future expectations. Front Radiat Ther Oncol. 2011;43:181–94.",{"doi":4726},"10.1159\u002F000322423",{"id":26,"text":4728,"url":26,"identifiers":4729},"Jung J, Song SY, Yoon SM, Kwak J, Yoon K, Choi W, et al. Verification of accuracy of CyberKnife tumor-tracking radiation therapy using patient-specific lung phantoms. Int J Radiat Oncol Biol Phys. 2015;92(4):745–53.",{"doi":4730},"10.1016\u002Fj.ijrobp.2015.02.055",{"id":26,"text":4732,"url":26,"identifiers":4733},"Chan M, Grehn M, Cremers F, Siebert F-A, Wurster S, Huttenlocher S, et al. Dosimetric implications of residual tracking errors during robotic SBRT of liver metastases. Int J Radiat Oncol Biol Phys. 2017;97(4):839–48.",{"doi":4734},"10.1016\u002Fj.ijrobp.2016.11.041",{"id":26,"text":4736,"url":26,"identifiers":4737},"Rossi L, Breedveld S, Aluwini S, Noncoplanar Beam HB. Angle class solutions to replace time-consuming patient-specific beam angle optimization in robotic prostate stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 2015;92(4):762–70.",{"doi":4738},"10.1016\u002Fj.ijrobp.2015.03.013",{"id":26,"text":4740,"url":26,"identifiers":4741},"Colvill E, Booth J, Nill S, Fast M, Bedford J, Oelfke U, et al. A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: a multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2016;119(1):159–65.",{"doi":4742},"10.1016\u002Fj.radonc.2016.03.006",{"id":4744,"createTime":4745,"updateTime":4746,"relativeEntities":4747,"slug":4748,"properties":4749,"entityType":829,"verifyStatus":25,"verifyTime":4746,"verifyNote":830,"syncStatus":28,"languages":4765,"translateLanguages":26,"viewCount":36,"primaryUrl":4766,"fullTextUrl":26,"authors":4767,"publicationType":918,"publisherRelationship":4973,"citationCount":627,"citationInfo":5004,"publishDate":2770,"publishYear":2771,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":5006,"isForceReanalyzing":1256},"878c028e-2c40-4d93-b023-44c2e601572b","2024-04-20T13:40:05.107+00:00","2025-02-18T08:30:01.624+00:00",[],"-68Ga-DOTATOC-PET-CT-for-meningioma-IMRT-treatment-planning",{"mag":4750,"keywords":4752,"pmc":4753,"openalex":4755,"abstract":4757,"title":4759,"pm":4761,"doi":4763},{"VOID":4751},"2171414123",{},{"VOID":4754},"2785827",{"VOID":4756},"W2171414123",{"EN":4758},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Purpose\u003C\u002Fjats:title>\n            \u003Cjats:p>The observation that human meningioma cells strongly express somatostatin receptor (SSTR 2) was the rationale to analyze retrospectively in how far DOTATOC PET\u002FCT is helpful to improve target volume delineation for intensity modulated radiotherapy (IMRT).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Patients and Methods\u003C\u002Fjats:title>\n            \u003Cjats:p>In 26 consecutive patients with preferentially skull base meningioma, diagnostic magnetic resonance imaging (MRI) and planning-computed tomography (CT) was complemented with data from [\u003Cjats:sup>68\u003C\u002Fjats:sup>Ga]-DOTA-D Phe\u003Cjats:sup>1\u003C\u002Fjats:sup>-Tyr\u003Cjats:sup>3\u003C\u002Fjats:sup>-Octreotide (DOTATOC)-PET\u002FCT. Image fusion of PET\u002FCT, diagnostic computed tomography, MRI and radiotherapy planning CT as well as target volume delineation was performed with OTP-Masterplan\u003Cjats:sup>®\u003C\u002Fjats:sup>. Initial gross tumor volume (GTV) definition was based on MRI data only and was secondarily complemented with DOTATOC-PET information. Irradiation was performed as EUD based IMRT, using the Hyperion Software package.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>The integration of the DOTATOC data led to additional information concerning tumor extension in 17 of 26 patients (65%). There were major changes of the clinical target volume (CTV) which modify the PTV in 14 patients, minor changes were realized in 3 patients. Overall the GTV-MRI\u002FCT was larger than the GTV-PET in 10 patients (38%), smaller in 13 patients (50%) and almost the same in 3 patients (12%). Most of the adaptations were performed in close vicinity to bony skull base structures or after complex surgery. Median GTV based on MRI was 18.1 cc, based on PET 25.3 cc and subsequently the CTV was 37.4 cc. Radiation planning and treatment of the DOTATOC-adapted volumes was feasible.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>DOTATOC-PET\u002FCT information may strongly complement patho-anatomical data from MRI and CT in cases with complex meningioma and is thus helpful for improved target volume delineation especially for skull base manifestations and recurrent disease after surgery.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":4760},"[68Ga]-DOTATOC-PET\u002FCT for meningioma IMRT treatment planning",{"VOID":4762},"19922642",{"VOID":4764},"10.1186\u002F1748-717x-4-56",[102],"https:\u002F\u002Fro-journal.biomedcentral.com\u002Farticles\u002F10.1186\u002F1748-717X-4-56",[4768,4790,4809,4830,4852,4871,4893,4908,4925,4939,4954],{"id":4769,"sortIndex":116,"researcher":26,"roles":4770,"affiliations":4771,"properties":4783},"1bc012bb-7b55-44d2-bcf3-a498de4ffc9b",[],[4772],{"id":4773,"sortIndex":36,"affiliation":4774,"properties":26},"ffa5ba1e-45ad-4e39-b62d-042a42e55341",{"id":4775,"createTime":4776,"updateTime":4777,"relativeEntities":4778,"slug":4779,"properties":4780,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"49a7aa8c-0f85-40e3-b93a-f8677419962b","2024-04-20T13:40:05.255+00:00","2024-08-31T12:35:00.725+00:00",[],"Department-of-Radiation-Oncology-LMU-M%C3%BCnchen-M%C3%BCnchen-81377-Germany",{"title":4781},{"EN":4782},"Department of Radiation Oncology, LMU München, München, 81377, Germany",{"openalex":4784,"orcid":4786,"title":4788},{"VOID":4785},"A5052937691",{"VOID":4787},"https:\u002F\u002Forcid.org\u002F0000-0003-4492-614X",{"EN":4789},"Ute Ganswindt",{"id":4791,"sortIndex":162,"researcher":26,"roles":4792,"affiliations":4793,"properties":4804},"9f079d72-589d-4f07-9c51-503a8e02eeef",[],[4794],{"id":4795,"sortIndex":36,"affiliation":4796,"properties":26},"750e4734-d81e-4c85-b3da-98810fc849b6",{"id":4797,"createTime":4798,"updateTime":4798,"relativeEntities":4799,"slug":4800,"properties":4801,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"25b6a665-be7a-4710-bab6-5e77e842efdd","2024-04-20T13:40:05.121+00:00",[],"Department-of-Nuclear-Medicine-University-of-T%C3%BCbingen-T%C3%BCbingen-72076-Germany",{"title":4802},{"EN":4803},"Department of Nuclear Medicine, University of Tübingen, Tübingen, 72076, Germany",{"openalex":4805,"title":4807},{"VOID":4806},"A5069332516",{"EN":4808},"Roland Bares",{"id":4810,"sortIndex":115,"researcher":26,"roles":4811,"affiliations":4812,"properties":4823},"6f4dae95-1ddc-4f44-b6df-f32dfb5bebd2",[],[4813],{"id":4814,"sortIndex":36,"affiliation":4815,"properties":26},"1b1f127f-67e8-4428-ba82-fdf7d7bf036e",{"id":4816,"createTime":4817,"updateTime":4817,"relativeEntities":4818,"slug":4819,"properties":4820,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"38f333a5-526b-4da1-8184-9c700db064db","2024-04-20T13:40:05.135+00:00",[],"Department-of-Radiation-Oncology-University-of-T%C3%BCbingen-T%C3%BCbingen-72076-Germany",{"title":4821},{"EN":4822},"Department of Radiation Oncology, University of Tübingen, Tübingen, 72076, Germany",{"openalex":4824,"orcid":4826,"title":4828},{"VOID":4825},"A5065356310",{"VOID":4827},"https:\u002F\u002Forcid.org\u002F0000-0001-8836-528X",{"EN":4829},"Frank Paulsen",{"id":4831,"sortIndex":50,"researcher":26,"roles":4832,"affiliations":4833,"properties":4845},"7b5ac8ac-0bdd-41ff-8661-5f0a442d763e",[],[4834],{"id":4835,"sortIndex":36,"affiliation":4836,"properties":26},"74d2a9dc-5ade-4779-a30f-dff93ba82fb5",{"id":4837,"createTime":4838,"updateTime":4839,"relativeEntities":4840,"slug":4841,"properties":4842,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"90fca6ad-d439-4f85-bd9c-77170d97a96e","2024-04-20T13:40:05.226+00:00","2024-10-17T15:10:43.319+00:00",[],"Department-of-Nuclear-Medicine-LMU-M%C3%BCnchen-M%C3%BCnchen-81377-Germany",{"title":4843},{"EN":4844},"Department of Nuclear Medicine, LMU München, München, 81377, Germany",{"openalex":4846,"orcid":4848,"title":4850},{"VOID":4847},"A5037412930",{"VOID":4849},"https:\u002F\u002Forcid.org\u002F0009-0005-0734-4994",{"EN":4851},"Peter Bartenstein",{"id":4853,"sortIndex":111,"researcher":26,"roles":4854,"affiliations":4855,"properties":4866},"a7147851-30d1-4e27-82ff-fb43bd1bfb4f",[],[4856],{"id":4857,"sortIndex":36,"affiliation":4858,"properties":26},"4c890b59-2d56-4353-a257-bf6acc2fefeb",{"id":4859,"createTime":4860,"updateTime":4860,"relativeEntities":4861,"slug":4862,"properties":4863,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"32e68ef6-b069-4986-9a61-0ae222d6e503","2024-04-20T13:40:05.175+00:00",[],"Medizinisches-Versorgungszentrum-Nuklearmedizin-Stuttgart-70199-Germany",{"title":4864},{"EN":4865},"Medizinisches Versorgungszentrum Nuklearmedizin, Stuttgart, 70199, Germany",{"openalex":4867,"title":4869},{"VOID":4868},"A5073500378",{"EN":4870},"Susanne 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