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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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SCIE","scie",[938,813],"SCIE","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1674-800X",[941],"8eb75d88-0c7a-497c-a346-e729afc75040",{"id":943,"indexDatabase":944,"url":949,"indexYears":950,"academicFieldIds":951,"indexDatabaseRanking":957},"4287ba02-80f1-404f-a6e6-4d524d47bea2",{"id":786,"createTime":28,"updateTime":28,"relativeEntities":945,"label":946,"description":947,"key":792,"publicationTags":948,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],"https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F19600166320","2010-2025",[952,953,954,955,956],"6fecd02d-a81f-4676-aae7-14033a2470d7","e89cebf4-fecf-4b74-8ab4-88fca891e4c2","578ed71b-dd6b-46c6-8851-2657dbd3629e","8fdfeff7-e31d-4d63-ae45-df54140f8b93","d2139bd1-2fdb-481b-a416-9c30dd0cc173","SCOPUS__Q1","https:\u002F\u002Flink.springer.com\u002Fjournal\u002F13238",{"impactFactor":32,"impactFactorByYear":960,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":123,"totalPublicationByYear":961,"totalCitation":32,"totalCitationByYear":962,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":963,"hindexLast5Year":32,"hindex":32},{},{"2021":40,"2022":40},{},{},{"meta":965,"data":967},{"total":966},"929",[968,1084,1293,1413,1563,1757,1938,2173,2278,2449],{"id":969,"createTime":970,"updateTime":971,"relativeEntities":972,"slug":973,"properties":974,"entityType":983,"verifyStatus":26,"verifyTime":971,"verifyNote":984,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":985,"fullTextUrl":28,"authors":986,"publicationType":1016,"publisherRelationship":1017,"citationCount":28,"citationInfo":28,"publishDate":1080,"publishYear":1081,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1082,"openAccess":28,"references":28,"isForceReanalyzing":1083},"00f76641-c39b-4067-94e8-32a4fdf7f671","2023-12-26T09:32:33.903+00:00","2025-01-03T20:23:28.643+00:00",[],"Structural-and-functional-roles-of-ether-lipids",{"abstract":975,"title":977,"references":979,"doi":981},{"EN":976},"Ether lipids, such as plasmalogens, are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seemingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential significance in human disorders, including neurological diseases, cancer, and metabolic disorders.",{"EN":978},"Structural and functional roles of ether lipids",{"VOID":980},"Albert DH, Anderson CE (1977) Ether-linked glycerolipids in human brain tumors. Lipids 12:188–192\nAlbert CJ, Thukkan AK, Heuertz RM et al (2003) Eosinophil peroxidase-derived reactive brominating species target the vinyl ether bond of plasmalogens generating a novel chemoattractant, alpha -bromo fatty aldehyde. J Biol Chem 278:8942–8950. doi:10.1074\u002Fjbc.M211634200\nAlshehry ZH, Mundra PA, Barlow CK et al (2016) Plasma lipidomic profiles improve on traditional risk factors for the prediction of cardiovascular events in type 2 diabetes mellitus clinical perspective. Circulation 134:1637–1650. doi:10.1161\u002FCIRCULATIONAHA.116.023233\nBarøy T, Koster J, Strømme P et al (2015) A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform. Hum Mol Genet 24:5845–5854. doi:10.1093\u002Fhmg\u002Fddv305\nBarr J, Caballería J, Martínez-Arranz I et al (2012) Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression. J Proteome Res 11:2521–2532. doi:10.1021\u002Fpr201223p\nBenjamin DI, Cozzo A, Ji X et al (2013) Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity. Proc Natl Acad Sci 110:14912–14917. doi:10.1073\u002Fpnas.1310894110\nBräutigam C, Engelmann B, Reiss D et al (1996) Plasmalogen phospholipids in plasma lipoproteins of normolipidemic donors and patients with hypercholesterolemia treated by LDL apheresis. Atherosclerosis 119:77–88\nBraverman NE, Moser AB (2012) Functions of plasmalogen lipids in health and disease. Biochim Biophys Acta BBA Mol Basis Dis 1822:1442–1452. doi:10.1016\u002Fj.bbadis.2012.05.008\nBraverman N, Steel G, Obie C et al (1997) Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata. Nat Genet 15:369–376\nBraverman NE, Raymond GV, Rizzo WB et al (2016) Peroxisome biogenesis disorders in the Zellweger spectrum: an overview of current diagnosis, clinical manifestations, and treatment guidelines. Mol Genet Metab 117:313–321. doi:10.1016\u002Fj.ymgme.2015.12.009\nBrites P (2003) Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. Hum Mol Genet 12:2255–2267. doi:10.1093\u002Fhmg\u002Fddg236\nBrites P, Ferreira AS, Ferreira da Silva T et al (2011) Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice. PLoS ONE 6:e28539. doi:10.1371\u002Fjournal.pone.0028539\nBrodde A, Teigler A, Brugger B et al (2012) Impaired neurotransmission in ether lipid-deficient nerve terminals. 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J Exp Med 199:763–774. doi:10.1084\u002Fjem.20031619\nZoeller RA, Morand OH, Raetz CR (1988) A possible role for plasmalogens in protecting animal cells against photosensitized killing. J Biol Chem 263:11590–11596",{"VOID":982},"10.1007\u002Fs13238-017-0423-5","PUBLICATION","Auto Verify","https:\u002F\u002Facademic.oup.com\u002Fproteincell\u002Farticle\u002F9\u002F2\u002F196\u002F6760084",[987,1003],{"id":988,"sortIndex":32,"researcher":28,"roles":989,"affiliations":991,"properties":1000,"displayName":1002,"givenName":28,"familyName":28},"a65c5c96-db61-4b7e-ba44-32092348bf58",[990],"AUTHOR",[992],{"id":993,"sortIndex":32,"affiliation":994,"properties":28},"276c6a40-2dc9-43b8-969a-e36370ab2a9e",{"id":993,"createTime":28,"updateTime":28,"relativeEntities":995,"slug":28,"properties":996,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":999,"statistic":28},[],{"title":997},{"VI":998},"Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, USA",[],{"title":1001},{"VI":1002},"John M. Dean",{"id":1004,"sortIndex":40,"researcher":28,"roles":1005,"affiliations":1006,"properties":1013,"displayName":1015,"givenName":28,"familyName":28},"05b434c2-0c37-4df2-bafd-340d5720d1c5",[990],[1007],{"id":993,"sortIndex":32,"affiliation":1008,"properties":28},{"id":993,"createTime":28,"updateTime":28,"relativeEntities":1009,"slug":28,"properties":1010,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1012,"statistic":28},[],{"title":1011},{"VI":998},[],{"title":1014},{"VI":1015},"Irfan J. Lodhi","ARTICLE",{"url":985,"publisher":1018,"properties":1075},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1019,"slug":872,"properties":1020,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1023,"manageAffiliations":1044,"indexDatabases":1055,"url":958,"thumbnailPath":28,"statistic":1070,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1021,"title":1022},{"VOID":875},{"EN":877},[1024,1028,1032,1036,1040],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":1025,"label":1026,"description":1027,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1029,"label":1030,"description":1031,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1033,"label":1034,"description":1035,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":1037,"label":1038,"description":1039,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},{"id":905,"createTime":28,"updateTime":28,"relativeEntities":1041,"label":1042,"description":1043,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":908},{},[1045,1050],{"id":912,"createTime":28,"updateTime":28,"relativeEntities":1046,"slug":28,"properties":1047,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1049,"statistic":28},[],{"title":1048},{"EN":916},[],{"id":919,"createTime":28,"updateTime":28,"relativeEntities":1051,"slug":28,"properties":1052,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1054,"statistic":28},[],{"title":1053},{"EN":923},[],[1056,1063],{"id":927,"indexDatabase":1057,"url":939,"indexYears":28,"academicFieldIds":1062,"indexDatabaseRanking":28},{"id":929,"createTime":28,"updateTime":28,"relativeEntities":1058,"label":1059,"description":1060,"key":936,"publicationTags":1061,"standard":28},[],{"EN":932,"VI":932},{"EN":934,"VI":935},[938,813],[941],{"id":943,"indexDatabase":1064,"url":949,"indexYears":950,"academicFieldIds":1069,"indexDatabaseRanking":957},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1065,"label":1066,"description":1067,"key":792,"publicationTags":1068,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[952,953,954,955,956],{"impactFactor":32,"impactFactorByYear":1071,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":123,"totalPublicationByYear":1072,"totalCitation":32,"totalCitationByYear":1073,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1074,"hindexLast5Year":32,"hindex":32},{},{"2021":40,"2022":40},{},{},{"pages":1076,"volume":1078},{"VOID":1077},"196-206",{"VOID":1079},"9","2017-05-18",2017,[938,957],false,{"id":1085,"createTime":1086,"updateTime":1086,"relativeEntities":1087,"slug":28,"properties":1088,"entityType":983,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1097,"fullTextUrl":28,"authors":1098,"publicationType":1016,"publisherRelationship":1227,"citationCount":28,"citationInfo":28,"publishDate":1290,"publishYear":1291,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1292,"openAccess":28,"references":28,"isForceReanalyzing":1083},"00fc981d-4bab-45ae-bc41-b8c5317d8b94","2024-01-21T00:09:52.924+00:00",[],{"abstract":1089,"title":1091,"references":1093,"doi":1095},{"EN":1090},"Gradient biomaterials are considered as preferable matrices for tissue engineering due to better simulation of native tissues. The introduction of gradient cues usually needs special equipment and complex process but is only effective to limited biomaterials. Incorporation of multiple gradients in the hydrogels remains challenges. Here, beta-sheet rich silk nanofibers (BSNF) were used as building blocks to introduce multiple gradients into different hydrogel systems through the joint action of crosslinking and electric field. The blocks migrated to the anode along the electric field and gradually stagnated due to the solution-hydrogel transition of the systems, finally achieving gradient distribution of the blocks in the formed hydrogels. The gradient distribution of the blocks could be tuned easily through changing different factors such as solution viscosity, which resulted in highly tunable gradient of mechanical cues. The blocks were also aligned under the electric field, endowing orientation gradient simultaneously. Different cargos could be loaded on the blocks and form gradient cues through the same crosslinking-electric field strategy. The building blocks could be introduced to various hydrogels such as Gelatin and NIPAM, indicating the universality. Complex niches with multiple gradient cues could be achieved through the strategy. Silk-based hydrogels with suitable mechanical gradients were fabricated to control the osteogenesis and chondrogenesis. Chondrogenic-osteogenic gradient transition was obtained, which stimulated the ectopic osteochondral tissue regeneration in vivo. The versatility and highly controllability of the strategy as well as multifunction of the building blocks reveal the applicability in complex tissue engineering and various interfacial tissues.",{"EN":1092},"Electric field-driven building blocks for introducing multiple gradients to hydrogels",{"VOID":1094},"Aigner TB, DeSimone E, Scheibel T (2018) Biomedical applications of recombinant silk-based materials. Adv Mater 30:e1704636\nBerger AJ, Linsmeier KM, Kreeger PK, Masters KS (2017) Decoupling the effects of stiffness and fiber density on cellular behaviors via an interpenetrating network of gelatin-methacrylate and collagen. Biomaterials 141:125–135\nBhardwaj N, Kundu SC (2012) Chondrogenic differentiation of rat MSCs on porous scaffolds of silk fibroin\u002Fchitosan blends. Biomaterials 33:2848–2857\nBracaglia LG, Smith BT, Watson E, Arumugasaamy N, Mikos AG, Fisher JP (2017) 3D printing for the design and fabrication of polymer-based gradient scaffolds. Acta Biomater 56:3–13\nDi Donato V, De Santis F, Albadri S, Auer TO, Duroure K, Charpentier M, Concordet JP, Gebhardt C, Del Bene F (2018) An attractive reelin gradient establishes synaptic lamination in the vertebrate visual system. Neuron 97(1049–1062):e1046\nDing Z, Fan Z, Huang X, Lu Q, Xu W, Kaplan DL (2016a) Silk-hydroxyapatite nanoscale scaffolds with programmable growth factor delivery for bone repair. ACS Appl Mater Interfaces 8:24463–24470\nDing ZZ, Fan ZH, Huang XW, Bai SM, Song DW, Lu Q, Kaplan DL (2016b) Bioactive natural protein-hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells. J Mater Chem B 4:3555–3561\nDong X, Zhao Q, Xiao L, Lu Q, Kaplan DL (2016) Amorphous silk nanofiber solutions for fabricating silk-based functional materials. Biomacromolecules 17:3000–3006\nDing Z, Han H, Fan Z, Lu H, Sang Y, Yao Y, Cheng Q, Lu Q, Kaplan DL (2017) Nanoscale silk-hydroxyapatite hydrogels for injectable bone biomaterials. ACS Appl Mater Interfaces 9:16913–16921\nEngler AJ, Sen S, Sweeney HL, Discher DE (2006) Matrix elasticity directs stem cell lineage specification. Cell 126:677–689\nGao Q, Niu X, Shao L, Zhou L, Lin Z, Sun A, Fu J, Chen Z, Hu J, Liu Y et al (2019) 3D printing of complex GelMA-based scaffolds with nanoclay. Biofabrication 11:035006\nHan H, Ning H, Liu S, Lu QP, Fan Z, Lu H, Lu G, Kaplan DL (2016) Silk biomaterials with vascularization capacity. Adv Funct Mater 26:421–436\nHassani Besheli N, Mottaghitalab F, Eslami M, Gholami M, Kundu SC, Kaplan DL, Farokhi M (2017) Sustainable release of vancomycin from silk fibroin nanoparticles for treating severe bone infection in rat tibia osteomyelitis model. ACS Appl Mater Interfaces 9:5128–5138\nHubka KM, Carson DD, Harrington DA, Farach-Carson MC (2019) Perlecan domain I gradients establish stable biomimetic heparin binding growth factor gradients for cell migration in hydrogels. Acta Biomater 97:385–398\nKo E, Lee JS, Kim H, Yang SY, Yang D, Yang K, Lee J, Shin J, Yang HS, Ryu W et al (2018) Electrospun silk fibroin nanofibrous scaffolds with two-stage hydroxyapatite functionalization for enhancing the osteogenic differentiation of human adipose-derived mesenchymal stem cells. ACS Appl Mater Interfaces 10:7614–7625\nKokkinis D, Bouville F, Studart AR (2018) 3D printing of materials with tunable failure via bioinspired mechanical gradients. Adv Mater 30:e1705808\nLevingstone TJ, Ramesh A, Brady RT, Brama PAJ, Kearney C, Gleeson JP, O’Brien FJ (2016) Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints. Biomaterials 87:69–81\nLi C, Armstrong JP, Pence IJ, Kit-Anan W, Puetzer JL, Correia Carreira S, Moore AC, Stevens MM (2018) Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering. Biomaterials 176:24–33\nLi C, Ouyang L, Pence IJ, Moore AC, Lin Y, Winter CW, Armstrong JPK, Stevens MM (2019) Buoyancy-driven gradients for biomaterial fabrication and tissue engineering. Adv Mater 31:e1900291\nLiao J, Tian T, Shi S, Xie X, Ma Q, Li G, Lin Y (2017) The fabrication of biomimetic biphasic CAN-PAC hydrogel with a seamless interfacial layer applied in osteochondral defect repair. Bone Res 5:17018\nLiu J, Ding Z, Lu G, Wang J, Wang L, Lu Q (2019) Amorphous silk fibroin nanofiber hydrogels with enhanced mechanical properties. Macromol Biosci 19(12):1900326\nLu HH, Thomopoulos S (2013) Functional attachment of soft tissues to bone: development, healing, and tissue engineering. Annu Rev Biomed Eng 15:201–226\nLu Q, Wang X, Lu S, Li M, Kaplan DL, Zhu H (2011) Nanofibrous architecture of silk fibroin scaffolds prepared with a mild self-assembly process. Biomaterials 32:1059–1067\nLu Q, Bai S, Ding Z, Guo H, Shao Z, Zhu H, Kaplan DL (2016) Hydrogel assembly with hierarchical alignment by balancing electrostatic forces. Adv Mater Interfaces 3:1500687\nLu G, Ding Z, Wei Y, Lu X, Lu Q, Kaplan DL (2018) Anisotropic biomimetic silk scaffolds for improved cell migration and healing of skin wounds. ACS Appl Mater Interfaces 10:44314–44323\nLu X, Ding Z, Xu F, Lu Q, Kaplan DL (2019) Subtle regulation of scaffold stiffness for the optimized control of cell behavior. ACS Appl Bio Mater 2:3108–3119\nMoller FM, Kriegel F, Kiess M, Sojo V, Braun D (2017) Steep pH gradients and directed colloid transport in a microfluidic alkaline hydrothermal pore. Angew Chem Int Ed Engl 56:2340–2344\nNaskar D, Ghosh AK, Mandal M, Das P, Nandi SK, Kundu SC (2017) Dual growth factor loaded nonmulberry silk fibroin\u002Fcarbon nanofiber composite 3D scaffolds for in vitro and in vivo bone regeneration. Biomaterials 136:67–85\nNonoyama T, Wada S, Kiyama R, Kitamura N, Mredha MT, Zhang X, Kurokawa T, Nakajima T, Takagi Y, Yasuda K et al (2016) Double-network hydrogels strongly bondable to bones by spontaneous osteogenesis penetration. Adv Mater 28:6740–6745\nOh SH, An DB, Kim TH, Lee JH (2016) Wide-range stiffness gradient PVA\u002FHA hydrogel to investigate stem cell differentiation behavior. Acta Biomater 35:23–31\nPogoda K, Bucki R, Byfield FJ, Cruz K, Lee T, Marcinkiewicz C, Janmey PA (2017) Soft substrates containing hyaluronan mimic the effects of increased stiffness on morphology, motility, and proliferation of glioma cells. Biomacromolecules 18:3040–3051\nRadhakrishnan J, Manigandan A, Chinnaswamy P, Subramanian A, Sethuraman S (2018) Gradient nano-engineered in situ forming composite hydrogel for osteochondral regeneration. Biomaterials 162:82–98\nRasib SZM, Ahmad Z, Khan A, Akil HM, Othman MBH, Hamid ZAA, Ullah F (2018) Synthesis and evaluation on pH- and temperature-responsive chitosan-p(MAA-co-NIPAM) hydrogels. Int J Biol Macromol 108:367–375\nRibeiro VP, da Silva Morais A, Maia FR, Canadas RF, Costa JB, Oliveira AL, Oliveira JM, Reis RL (2018) Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration. Acta Biomater 72:167–181\nShen X, Zhang Y, Gu Y, Xu Y, Liu Y, Li B, Chen L (2016) Sequential and sustained release of SDF-1 and BMP-2 from silk fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration. Biomaterials 106:205–216\nStudle C, Vallmajo-Martin Q, Haumer A, Guerrero J, Centola M, Mehrkens A, Schaefer DJ, Ehrbar M, Barbero A, Martin I (2018) Spatially confined induction of endochondral ossification by functionalized hydrogels for ectopic engineering of osteochondral tissues. Biomaterials 171:219–229\nVedadghavami A, Minooei F, Mohammadi MH, Khetani S, Rezaei Kolahchi A, Mashayekhan S, Sanati-Nezhad A (2017) Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications. Acta Biomater 62:42–63\nWang L, Lu G, Lu Q, Kaplan DL (2018a) Controlling cell behavior on silk nanofiber hydrogels with tunable anisotropic structures. ACS Biomater Sci Eng 4:933–941\nWang L, Song D, Zhang X, Ding Z, Kong X, Lu Q, Kaplan DL (2018b) Silk-graphene hybrid hydrogels with multiple cues to induce nerve cell behavior. ACS Biomater Sci Eng 5:613–622\nWu H, Liu S, Xiao L, Dong X, Lu Q, Kaplan DL (2016) Injectable and pH-responsive silk nanofiber hydrogels for sustained anticancer drug delivery. ACS Appl Mater Interfaces 8:17118–17126\nWu T, Xue J, Li H, Zhu C, Mo X, Xia Y (2018) General method for generating circular gradients of active proteins on nanofiber scaffolds sought for wound closure and related applications. ACS Appl Mater Interfaces 10:8536–8545\nXu F, Ma F, Ding Z, Xiao L, Zhang X, Lu Q, Lu G, Kaplan DL (2019) SERS substrate with silk nanoribbons as interlayer template. ACS Appl Mater Interfaces 11:42896–42903\nYang J, Liu Y, He L, Wang Q, Wang L, Yuan T, Xiao Y, Fan Y, Zhang X (2018) Icariin conjugated hyaluronic acid\u002Fcollagen hydrogel for osteochondral interface restoration. Acta Biomater 74:156–167\nYin L, Wu Y, Yang Z, Denslin V, Ren X, Tee CA, Lai Z, Lim CT, Han J, Lee EH (2018) Characterization and application of size-sorted zonal chondrocytes for articular cartilage regeneration. Biomaterials 165:66–78\nZhang W, Yang G, Wang X, Jiang L, Jiang F, Li G, Zhang Z, Jiang X (2017) Magnetically controlled growth-factor-immobilized multilayer cell sheets for complex tissue regeneration. Adv Mater 29(43):1703795\nZhang X, Wang L, Lu Q, Kaplan DL (2018) Mass production of biocompatible graphene using silk nanofibers. ACS Appl Mater Interfaces 10:22924–22931",{"VOID":1096},"10.1007\u002Fs13238-020-00692-z","https:\u002F\u002Facademic.oup.com\u002Fproteincell\u002Farticle\u002F11\u002F4\u002F267\u002F6746747",[1099,1123,1138,1160,1173,1186,1199,1212],{"id":1100,"sortIndex":32,"researcher":28,"roles":1101,"affiliations":1102,"properties":1120,"displayName":1122,"givenName":28,"familyName":28},"b2a1b649-dde5-4d0d-b9d9-c7c0bcbb064f",[990],[1103,1111],{"id":1104,"sortIndex":32,"affiliation":1105,"properties":28},"64e54757-19a9-49a9-84e9-e063a2d14682",{"id":1104,"createTime":28,"updateTime":28,"relativeEntities":1106,"slug":28,"properties":1107,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1110,"statistic":28},[],{"title":1108},{"VI":1109},"Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China",[],{"id":1112,"sortIndex":40,"affiliation":1113,"properties":1119},"37f8f5ed-66f5-4fcf-963e-ba9b097a3973",{"id":1112,"createTime":28,"updateTime":28,"relativeEntities":1114,"slug":28,"properties":1115,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1118,"statistic":28},[],{"title":1116},{"VI":1117},"Department of Orthopedics, Affiliated Hospital of Xuzhou Medical University, Lianyungang, China",[],{},{"title":1121},{"VI":1122},"Gang Xu",{"id":1124,"sortIndex":40,"researcher":28,"roles":1125,"affiliations":1126,"properties":1135,"displayName":1137,"givenName":28,"familyName":28},"bf2b8a20-b7f8-4de4-a1d4-2a95de27ffd4",[990],[1127],{"id":1128,"sortIndex":32,"affiliation":1129,"properties":28},"1720ec7d-e075-4455-964a-b591a844e429",{"id":1128,"createTime":28,"updateTime":28,"relativeEntities":1130,"slug":28,"properties":1131,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1134,"statistic":28},[],{"title":1132},{"VI":1133},"Department of Burns and Plastic Surgery, Engineering Research Center of the Ministry of Education for Wound Repair Technology, The Affiliated Hospital of Jiangnan University, Wuxi, China",[],{"title":1136},{"VI":1137},"Zhaozhao Ding",{"id":1139,"sortIndex":123,"researcher":28,"roles":1140,"affiliations":1141,"properties":1157,"displayName":1159,"givenName":28,"familyName":28},"e3d4bc9b-1249-4fd8-a7c5-4e938691711a",[990],[1142,1148],{"id":1128,"sortIndex":32,"affiliation":1143,"properties":28},{"id":1128,"createTime":28,"updateTime":28,"relativeEntities":1144,"slug":28,"properties":1145,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1147,"statistic":28},[],{"title":1146},{"VI":1133},[],{"id":1149,"sortIndex":40,"affiliation":1150,"properties":1156},"498ada6d-d7cf-4e93-9f44-d4d04ae973d9",{"id":1149,"createTime":28,"updateTime":28,"relativeEntities":1151,"slug":28,"properties":1152,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1155,"statistic":28},[],{"title":1153},{"VI":1154},"National Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, China",[],{},{"title":1158},{"VI":1159},"Qiang Lu",{"id":1161,"sortIndex":42,"researcher":28,"roles":1162,"affiliations":1163,"properties":1170,"displayName":1172,"givenName":28,"familyName":28},"c66cff16-1569-451a-93b1-2d441b292b3d",[990],[1164],{"id":1149,"sortIndex":32,"affiliation":1165,"properties":28},{"id":1149,"createTime":28,"updateTime":28,"relativeEntities":1166,"slug":28,"properties":1167,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1169,"statistic":28},[],{"title":1168},{"VI":1154},[],{"title":1171},{"VI":1172},"Xiaoyi 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Xiao",{"id":1200,"sortIndex":48,"researcher":28,"roles":1201,"affiliations":1202,"properties":1209,"displayName":1211,"givenName":28,"familyName":28},"9e91065a-ca5a-4273-bd5b-62859f17a3ba",[990],[1203],{"id":1128,"sortIndex":32,"affiliation":1204,"properties":28},{"id":1128,"createTime":28,"updateTime":28,"relativeEntities":1205,"slug":28,"properties":1206,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1208,"statistic":28},[],{"title":1207},{"VI":1133},[],{"title":1210},{"VI":1211},"Guozhong Lu",{"id":1213,"sortIndex":49,"researcher":28,"roles":1214,"affiliations":1215,"properties":1224,"displayName":1226,"givenName":28,"familyName":28},"753a2ef3-6a05-4de6-8c0b-cfff5ed9e01e",[990],[1216],{"id":1217,"sortIndex":32,"affiliation":1218,"properties":28},"83eaecca-d6b0-43b9-b40f-7322208959bb",{"id":1217,"createTime":28,"updateTime":28,"relativeEntities":1219,"slug":28,"properties":1220,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1223,"statistic":28},[],{"title":1221},{"VI":1222},"Department of Biomedical Engineering, Tufts University, Medford, USA",[],{"title":1225},{"VI":1226},"David L Kaplan",{"url":1097,"publisher":1228,"properties":1285},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1229,"slug":872,"properties":1230,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1233,"manageAffiliations":1254,"indexDatabases":1265,"url":958,"thumbnailPath":28,"statistic":1280,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1231,"title":1232},{"VOID":875},{"EN":877},[1234,1238,1242,1246,1250],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":1235,"label":1236,"description":1237,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":1239,"label":1240,"description":1241,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":1243,"label":1244,"description":1245,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":1247,"label":1248,"description":1249,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},{"id":905,"createTime":28,"updateTime":28,"relativeEntities":1251,"label":1252,"description":1253,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":908},{},[1255,1260],{"id":912,"createTime":28,"updateTime":28,"relativeEntities":1256,"slug":28,"properties":1257,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1259,"statistic":28},[],{"title":1258},{"EN":916},[],{"id":919,"createTime":28,"updateTime":28,"relativeEntities":1261,"slug":28,"properties":1262,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1264,"statistic":28},[],{"title":1263},{"EN":923},[],[1266,1273],{"id":927,"indexDatabase":1267,"url":939,"indexYears":28,"academicFieldIds":1272,"indexDatabaseRanking":28},{"id":929,"createTime":28,"updateTime":28,"relativeEntities":1268,"label":1269,"description":1270,"key":936,"publicationTags":1271,"standard":28},[],{"EN":932,"VI":932},{"EN":934,"VI":935},[938,813],[941],{"id":943,"indexDatabase":1274,"url":949,"indexYears":950,"academicFieldIds":1279,"indexDatabaseRanking":957},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":1275,"label":1276,"description":1277,"key":792,"publicationTags":1278,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[952,953,954,955,956],{"impactFactor":32,"impactFactorByYear":1281,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":123,"totalPublicationByYear":1282,"totalCitation":32,"totalCitationByYear":1283,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1284,"hindexLast5Year":32,"hindex":32},{},{"2021":40,"2022":40},{},{},{"pages":1286,"volume":1288},{"VOID":1287},"267-285",{"VOID":1289},"11","2020-02-12",2020,[938,957],{"id":1294,"createTime":1295,"updateTime":1296,"relativeEntities":1297,"slug":1298,"properties":1299,"entityType":983,"verifyStatus":26,"verifyTime":1296,"verifyNote":984,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1308,"fullTextUrl":28,"authors":1309,"publicationType":1016,"publisherRelationship":1347,"citationCount":28,"citationInfo":28,"publishDate":1410,"publishYear":1411,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":1412,"openAccess":28,"references":28,"isForceReanalyzing":1083},"00fe6486-13c4-42b8-8d7d-ac8ba5db9908","2023-12-12T00:03:34.464+00:00","2024-12-22T13:50:11.041+00:00",[],"DNA-replication-licensing-control-and-rereplication-prevention",{"abstract":1300,"title":1302,"references":1304,"doi":1306},{"EN":1301},"Eukaryotic DNA replication is tightly restricted to only once per cell cycle in order to maintain genome stability. Cells use multiple mechanisms to control the assembly of the prereplication complex (pre-RC), a process known as replication licensing. This review focuses on the regulation of replication licensing by posttranslational modifications of the licensing factors, including phosphorylation, ubiquitylation and acetylation. These modifications are critical in establishing the pre-RC complexes as well as preventing rereplication in each cell cycle. The relationship between rereplication and diseases, including cancer and virus infection, is discussed as well.",{"EN":1303},"DNA replication licensing control and rereplication prevention",{"VOID":1305},"Abbas, T., Sivaprasad, U., Terai, K., Amador, V., Pagano, M., and Dutta, A. (2008). PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. 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Human CUL-1 associates with the SKP1\u002FSKP2 complex and regulates p21 (CIP1\u002FWAF1) and cyclin D proteins. Proc Natl Acad Sci U S A 95, 11324–11329.\nZhong, W., Feng, H., Santiago, F.E., and Kipreos, E.T. (2003). CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature 423, 885–889.\nZhu, W., and Depamphilis, M.L. (2009). Selective killing of cancer cells by suppression of geminin activity. Cancer Res 69, 4870–4877.\nZoulim, F., Saputelli, J., and Seeger, C. (1994). Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 68, 2026–2030.",{"VOID":1307},"10.1007\u002Fs13238-010-0032-z","https:\u002F\u002Facademic.oup.com\u002Fproteincell\u002Farticle\u002F1\u002F3\u002F227\u002F6842764",[1310,1325],{"id":1311,"sortIndex":32,"researcher":28,"roles":1312,"affiliations":1313,"properties":1322,"displayName":1324,"givenName":28,"familyName":28},"45de903e-9601-4530-aacb-e342b08876ab",[990],[1314],{"id":1315,"sortIndex":32,"affiliation":1316,"properties":28},"2ad348a4-2fbf-4219-8039-82ae07e2b411",{"id":1315,"createTime":28,"updateTime":28,"relativeEntities":1317,"slug":28,"properties":1318,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1321,"statistic":28},[],{"title":1319},{"VI":1320},"Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, USA",[],{"title":1323},{"VI":1324},"Chonghua 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potent PROTACs tools for selective degradation of HDAC6 protein",{"VOID":1423},"Batchu SN, Brijmohan AS, Advani A (2016) The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease. Clin Sci (Lond) 130:987–1003\nBergman JA, Woan K, Perez-Villarroel P, Villagra A, Sotomayor EM, Kozikowski AP (2012) Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem 55:9891–9899\nBoettcher M, McManus MT (2015) Choosing the right tool for the job: RNAi, TALEN, or CRISPR. Mol Cell 58:575–585\nDavisson MT, Bergstrom DE, Reinholdt LG, Donahue LR (2012) Discovery genetics—the history and future of spontaneous mutation research. Curr Protoc Mouse Biol 2:103–118\nEl-Brolosy MA, Stainier DYR (2017) Genetic compensation: a phenomenon in search of mechanisms. PLoS Genet 13:e1006780\nKawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115:727–738\nKuhn DJ, Chen Q, Voorhees PM, Strader JS, Shenk KD, Sun CM, Demo SD, Bennett MK, Van Leeuwen FW, Chanan-Khan AA et al (2007) Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 110:3281–3290\nLai AC, Crews CM (2017) Induced protein degradation: an emerging drug discovery paradigm. Nat Rev Drug Discov 16:101–114\nLopez-Girona A, Mendy D, Ito T, Miller K, Gandhi AK, Kang J, Karasawa S, Carmel G, Jackson P, Abbasian M et al (2012) Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26:2326–2335\nMiyake Y, Keusch JJ, Wang L, Saito M, Hess D, Wang X, Melancon BJ, Helquist P, Gut H, Matthias P (2016) Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol 12:748–754\nSeto E, Yoshida M (2014) Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol 6:a018713\nSun YH, Zhao XW, Ding N, Gao HY, Wu Y, Yang YQ, Zhao M, Hwang J, Song YG, Liu WL et al (2018) PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies. Cell Res 28:779–781\nValenzuela-Fernandez A, Cabrero JR, Serrador JM, Sanchez-Madrid F (2008) HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol 18:291–297\nYang K, Song Y, Xie H, Wu H, Wu YT, Leisten ED, Tang W (2018) Development of the first small molecule histone deacetylase 6 (HDAC6) degraders. Bioorg Med Chem Lett 28:2493–2497\nZhou B, Hu JT, Xu F, Chen Z, Bai L, Fernandez-Salas E, Lin M, Liu L, Yang CY, Zhao Y et al (2018) Discovery of a small-molecule degrader of bromodomain and extra-terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor regression. J Med Chem 61:462–481",{"VOID":1425},"10.1007\u002Fs13238-018-0602-z","https:\u002F\u002Facademic.oup.com\u002Fproteincell\u002Farticle\u002F10\u002F8\u002F606\u002F6759291",[1428,1443,1458,1471,1484],{"id":1429,"sortIndex":32,"researcher":28,"roles":1430,"affiliations":1431,"properties":1440,"displayName":1442,"givenName":28,"familyName":28},"f4279f81-9b64-4b88-b695-3e02c6229b89",[990],[1432],{"id":1433,"sortIndex":32,"affiliation":1434,"properties":28},"43c75f23-08c4-4076-862e-e7667b6830a1",{"id":1433,"createTime":28,"updateTime":28,"relativeEntities":1435,"slug":28,"properties":1436,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1439,"statistic":28},[],{"title":1437},{"EN":1438},"MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, China",[],{"title":1441},{"VI":1442},"Zixuan 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recent years, large numbers of non-coding RNAs (ncRNAs) have been identified in\n                    C. elegans but their functions are still not\n                well studied. In C. elegans, CEP-1 is the sole homolog of the p53 family of genes.\n                In order to obtain transcription profiles of ncRNAs regulated by CEP-1 under normal\n                and UV stressed conditions, we applied the ‘not-so-random’ hexamers priming strategy\n                to RNA sequencing in C. elegans, This NSR-seq\n                strategy efficiently depleted rRNA transcripts from the samples and showed high\n                technical replicability. We identified more than 1,000 ncRNAs whose apparent\n                expression was repressed by CEP-1, while around 200 were activated. Around 40% of\n                the CEP-1 activated ncRNAs promoters contain a putative CEP-1-binding site. CEP-1\n                regulated ncRNAs were frequently clustered and concentrated on the X chromosome.\n                These results indicate that numerous ncRNAs are involved in CEP-1 transcriptional\n                network and that these are especially enriched on the X chromosome in C. elegans.",{"EN":1573},"Analysis of the p53\u002FCEP-1 regulated non-coding transcriptome in C. elegans by an NSR-seq strategy",{"VOID":1575},"Adriaenssens E, Dumont L, Lottin S, Bolle D, Lepretre A, Delobelle A, Bouali F, Dugimont T, Coll J, Curgy JJ (1998) H19 overexpression in breast adenocarcinoma stromal cells is associated with tumor values and steroid receptor status but independent of p53 and Ki-67 expression. Am J Pathol 153:1597–1607\nAgostini M, Tucci P, Chen H, Knight RA, Bano D, Nicotera P, McKeon F, Melino G (2010) p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun 403:13–17\nAird D, Ross MG, Chen WS, Danielsson M, Fennell T, Russ C, Jaffe DB, Nusbaum C, Gnirke A (2011) Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries. Genome Biol 12:R18\nAllen MA, Hillier LW, Waterston RH, Blumenthal T (2011) A global analysis of C. elegans trans-splicing. Genome Res 21:255–264\nArmour CD, Castle JC, Chen R, Babak T, Loerch P, Jackson S, Shah JK, Dey J, Rohl CA, Johnson JM et al (2009) Digital transcriptome profiling using selective hexamer priming for cDNA synthesis. Nat Methods 6:647–649\nBerkers CR, Maddocks OD, Cheung EC, Mor I, Vousden KH (2013) Metabolic regulation by p53 family members. Cell Metab 18:617–633\nBoominathan L (2010) The tumor suppressors p53, p63, and p73 are regulators of MicroRNA processing complex. PloS one 5:e10615\nC. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282: 2012–2018\nChristov CP, Trivier E, Krude T (2008) Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation. Br J Cancer 98:981–988\nCrighton D, Woiwode A, Zhang C, Mandavia N, Morton JP, Warnock LJ, Milner J, White RJ, Johnson DL (2003) p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. Embo J 22:2810–2820\nDeng W, Zhu XP, Skogerbo G, Zhao Y, Fu Z, Wang YD, He HS, Cai L, Sun H, Liu CN et al (2006) Organization of the Caenorhabditis elegans small non-coding transcriptome: Genomic features, biogenesis, and expression. Genome Res 16:20–29\nDerry WB, Putzke AP, Rothman JH (2001) Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science 294:591–595\nDerry WB, Bierings R, van Iersel M, Satkunendran T, Reinke V, Rothman JH (2007) Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network. 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Nature 482:339–346\nGuttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP et al (2009) Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458:223–227\nHe H, Wang J, Liu T, Liu XS, Li T, Wang Y, Qian Z, Zheng H, Zhu X, Wu T et al (2007) Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray. Genome Res 17:1471–1477\nHo J, Benchimol S (2003) Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Diff 10:404–408\nHuarte M, Rinn JL (2010) Large non-coding RNAs: missing links in cancer? Hum Mol Genet 19:R152–R161\nHuarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M et al (2010) A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. 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J Biol Chem 282:24731–24742",{"VOID":1577},"10.1007\u002Fs13238-014-0071-y","https:\u002F\u002Facademic.oup.com\u002Fproteincell\u002Farticle\u002F5\u002F10\u002F770\u002F6831779",[1580,1604,1624,1639,1652,1665,1678],{"id":1581,"sortIndex":32,"researcher":28,"roles":1582,"affiliations":1583,"properties":1601,"displayName":1603,"givenName":28,"familyName":28},"1327810c-0be5-47ba-be7c-ebc3488620f9",[990],[1584,1592],{"id":1585,"sortIndex":32,"affiliation":1586,"properties":28},"4b2f1d06-e2e3-42b1-aaee-49af441f6f69",{"id":1585,"createTime":28,"updateTime":28,"relativeEntities":1587,"slug":28,"properties":1588,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1591,"statistic":28},[],{"title":1589},{"VI":1590},"Laboratory of Non-coding RNA, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing, 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integrate various environmental stimuli within the nervous system to generate proper behavioral responses. However, the underlying neural circuits and molecular mechanisms are largely unknown. The insulinlike signaling pathway is known to regulate dauer formation, fat metabolism, and longevity in Caenorhabditis elegans (C. Elegans). Here, we show that this highly conserved signaling pathway also functions in the integrative response to an olfactory diacetyl and a gustatory Cu2+ stimuli. Worms of wild-type N2 Bristol displayed a strong avoidance to the Cu2+ barrier in the migration pathway to the attractive diacetyl. Mutants of daf-2 (insulin receptor), daf-18 (PTEN lipid phosphatase), pdk-1 (phosphoinositide-dependent kinase), akt-1\u002F-2 (Akt\u002FPKB kinase) and sgk-1 (serum- and glucocorticoidinducible kinase) show severe defects in the elusion from the Cu2+. Mutations in DAF-16, a forkhead-type transcriptional factor, suppress the integrative defects of daf-2 and akt-1\u002F-2 mutants. We further report that neither cGMP nor TGFβ pathways, two other dauer formation regulators, likely plays a role in the integrative learning. These results suggest that the insulin-like signaling pathway constitutes an essential component for sensory integration and decision-making behavior plasticity.",{"EN":1765},"Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans",{"VOID":1767},"Bargmann, C.I., Hartwieg, E., and Horvitz, H.R. (1993). Odorantselective genes and neurons mediate olfaction in C. elegans. Cell 74, 515–527.\nBargmann, C.I., and Kaplan, J.M. (1998). Signal transduction in the Caenorhabditis elegans nervous system. Annu Rev Neurosci 21, 279–308.\nBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71–94.\nCalvert, G.A., Hansen, P.C., Iversen, S.D., and Brammer, M.J. (2001). Detection of audio-visual integration sites in humans by application of electrophysiological criteria to the BOLD effect. Neuroimage 14, 427–438.\nCelikel, T., and Sakmann, B. (2007). Sensory integration across space and in time for decision making in the somatosensory system of rodents. Proc Natl Acad Sci U S A 104, 1395–1400.\nColbert, H.A., and Bargmann, C.I. (1995). Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron 14, 803–812.\nCronin, C.J., Mendel, J.E., Mukhtar, S., Kim, Y.M., Stirbl, R.C., Bruck, J., and Sternberg, P.W. (2005). An automated system for measuring parameters of nematode sinusoidal movement. BMC Genet 6, 5.\nGuo, J., and Guo, A. (2005). Crossmodal interactions between olfactory and visual learning in Drosophila. Science 309, 307–310.\nIkeda, D.D., Duan, Y., Matsuki, M., Kunitomo, H., Hutter, H., Hedgecock, E.M., and Iino, Y. (2008). CASY-1, an ortholog of calsyntenins\u002Falcadeins, is essential for learning in Caenorhabditis elegans. Proc Natl Acad Sci U S A 105, 5260–5265.\nIshihara, T., Iino, Y., Mohri, A., Mori, I., Gengyo-Ando, K., Mitani, S., and Katsura, I. (2002). HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. Cell 109, 639–649.\nKodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K.D., Okumura, M., Tomioka, M., Iino, Y., and Mori, I. (2006). Insulin-like signaling and the neural circuit for integrative behavior in C. elegans. Genes Dev 20, 2955–2960.\nLackner, M.R., Nurrish, S.J., and Kaplan, J.M. (1999). Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron 24, 335–346.\nMatsuki, M., Kunitomo, H., and Iino, Y. (2006). Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. 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Nat Biotechnol 35:438–440",{"VOID":2290},"10.1007\u002Fs13238-018-0594-8","https:\u002F\u002Facademic.oup.com\u002Fproteincell\u002Farticle\u002F10\u002F7\u002F470\u002F6759303",[2293,2308,2321,2336,2356,2371],{"id":2294,"sortIndex":32,"researcher":28,"roles":2295,"affiliations":2296,"properties":2305,"displayName":2307,"givenName":28,"familyName":28},"f890655d-ff39-4654-a223-5c8e73257392",[990],[2297],{"id":2298,"sortIndex":32,"affiliation":2299,"properties":28},"548260d9-ed01-4c81-b670-af13095f8901",{"id":2298,"createTime":28,"updateTime":28,"relativeEntities":2300,"slug":28,"properties":2301,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2304,"statistic":28},[],{"title":2302},{"VI":2303},"Key Laboratory for Major Obstetric Diseases of Guangdong Province, Center of Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 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Fan",{"url":2291,"publisher":2385,"properties":2442},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2386,"slug":872,"properties":2387,"entityType":25,"verifyStatus":878,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2390,"manageAffiliations":2411,"indexDatabases":2422,"url":958,"thumbnailPath":28,"statistic":2437,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":2388,"title":2389},{"VOID":875},{"EN":877},[2391,2395,2399,2403,2407],{"id":881,"createTime":28,"updateTime":28,"relativeEntities":2392,"label":2393,"description":2394,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":884},{},{"id":887,"createTime":28,"updateTime":28,"relativeEntities":2396,"label":2397,"description":2398,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":890},{},{"id":893,"createTime":28,"updateTime":28,"relativeEntities":2400,"label":2401,"description":2402,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":896},{},{"id":899,"createTime":28,"updateTime":28,"relativeEntities":2404,"label":2405,"description":2406,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":902},{},{"id":905,"createTime":28,"updateTime":28,"relativeEntities":2408,"label":2409,"description":2410,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":908},{},[2412,2417],{"id":912,"createTime":28,"updateTime":28,"relativeEntities":2413,"slug":28,"properties":2414,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2416,"statistic":28},[],{"title":2415},{"EN":916},[],{"id":919,"createTime":28,"updateTime":28,"relativeEntities":2418,"slug":28,"properties":2419,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2421,"statistic":28},[],{"title":2420},{"EN":923},[],[2423,2430],{"id":927,"indexDatabase":2424,"url":939,"indexYears":28,"academicFieldIds":2429,"indexDatabaseRanking":28},{"id":929,"createTime":28,"updateTime":28,"relativeEntities":2425,"label":2426,"description":2427,"key":936,"publicationTags":2428,"standard":28},[],{"EN":932,"VI":932},{"EN":934,"VI":935},[938,813],[941],{"id":943,"indexDatabase":2431,"url":949,"indexYears":950,"academicFieldIds":2436,"indexDatabaseRanking":957},{"id":786,"createTime":28,"updateTime":28,"relativeEntities":2432,"label":2433,"description":2434,"key":792,"publicationTags":2435,"standard":28},[],{"EN":789,"VI":789},{"EN":789,"VI":791},[794],[952,953,954,955,956],{"impactFactor":32,"impactFactorByYear":2438,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":123,"totalPublicationByYear":2439,"totalCitation":32,"totalCitationByYear":2440,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":2441,"hindexLast5Year":32,"hindex":32},{},{"2021":40,"2022":40},{},{},{"pages":2443,"volume":2445},{"VOID":2444},"470-475",{"VOID":1559},"2018-11-14",2018,[938,957],{"id":2450,"createTime":2451,"updateTime":2452,"relativeEntities":2453,"slug":2454,"properties":2455,"entityType":983,"verifyStatus":26,"verifyTime":2452,"verifyNote":984,"languages":28,"translateLanguages":28,"viewCount":123,"primaryUrl":2464,"fullTextUrl":28,"authors":2465,"publicationType":1016,"publisherRelationship":2568,"citationCount":28,"citationInfo":28,"publishDate":2630,"publishYear":1291,"citationAnalyzeStatus":878,"lastCitationAnalyze":28,"indexDatabases":2631,"openAccess":28,"references":28,"isForceReanalyzing":1083},"0345827a-0ffe-4f8e-93fb-4c467005d145","2023-12-08T01:43:21.811+00:00","2025-01-02T09:19:41.255+00:00",[],"Lifting-the-veil-on-the-keratinocyte-contribution-to-cutaneous-nociception",{"abstract":2456,"title":2458,"references":2460,"doi":2462},{"EN":2457},"Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most modulated by keratinocytes. However recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory neurons. To enlighten our understanding of cutaneous nociception, this review highlights recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors, both under healthy and pathological conditions.",{"EN":2459},"Lifting the veil on the keratinocyte contribution to cutaneous nociception",{"VOID":2461},"Abraira VE, Ginty DD (2013) The sensory neurons of touch. 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