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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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more studies report on patient preferences, techniques are needed to identify, assess and, eventually, synthesize results from a diverse set of methodologies. Data on patient preferences are valuable to decision makers in a variety of ways. Preferences for outcomes can be used to inform decision and cost-effectiveness models, while preferences for treatments can inform patient-centered outcomes research (PCOR) and patient-centered care. This project sought to identify and assess the literature reporting on the treatment preferences of adult patients with type 2 diabetes. In addition to cataloging the preference elicitation methods used, we developed and assessed a novel quality assessment checklist for preference-based studies. PubMed, EMBASE, CINAHL, and EconLit databases were searched to identify studies examining patient preferences for medications for type 2 diabetes studies published since inception of each database. The review protocol specified inclusion of studies reporting diabetes-treatment preferences among adults with type 2 diabetes, using a range of preference measurement methods. Studies were excluded if participants were not patients with type 2 diabetes and if treatments were not pharmacological therapies targeting glycemic control, or if no primary preference information was collected. Two investigators independently reviewed titles, abstracts, and articles sequentially to select studies for data abstraction based on the inclusion and exclusion criteria. Disagreements were resolved by consensus. Data on study country, year, number of respondents, preference elicitation method, number of attributes, subgroup analyses, and funding source were abstracted into standardized tables. A novel checklist (PREFS) was used to assess the data quality and validity across different types of preference studies by assessing the following: purpose of the study; respondent sampling; explanation of preference assessment methods; findings reported for total sample; and significance testing. Each item was scored, and an aggregate score was then calculated (ranging from 0 to 5). Of the 2,100 unique citations, 61 met the inclusion criteria. The studies used conjoint analysis (n = 10), time trade-off (n = 6), standard gamble (n = 2), contingent valuation (n = 1), other stated preference methods (n = 39), and revealed preferences (n = 5). Sample sizes ranged from 27 to 14,033, with an average of 562 respondents, and two-thirds included a subgroup analysis. Most studies were conducted in one country, predominantly the USA (n = 27), UK (n = 14), Canada (n = 10), and Germany (n = 7), while 14 were conducted in multiple (2–18) countries across two or more countries. There was an increase in the annual rate of studies published over time from the time of the first publication in 1985 (p = < 0.01). Most (n = 52) studies were funded by pharmaceutical or device companies, with government, academic, association, and hospital sources also funding studies. One study met all five of the PREFS criteria and 12 met four; yet four studies met none of the criteria. The average was 27. Currently, preferences reviews are limited by the mixed quality in the reporting of studies, the publication bias inherent in the literature, a lack of guidelines to conduct various methods, and the difficulty of synthesizing results from different studies. Our study is also limited by its focus on English language articles. This study provides the first systematic evaluation of the methods used in the broad existing body of research into patient preferences for type 2 diabetes medications and can serve as a primary source of information for decision makers. Future work is necessary to assess the utility of the results of reviews of preference information and to develop best-practice guidelines for the reporting of, and methods of conducting, preference studies and systematic reviews of such studies. This systematic review was registered with PROSPERO (registration number CRD42012002285).",{"EN":982},"Patient Preferences for the Treatment of Type 2 Diabetes: A Scoping Review",{"VOID":984},"Patient Protection and Affordable Care Act (2010) (USA). H. R. 3590. 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A decision-tree model was used to estimate the cost effectiveness of aciclovir, from third-party payer and societal perspectives: the incremental cost per qualityadjusted life-year (QALY) gained was calculated for aciclovir treatment of chickenpox compared with no antiviral therapy in immunocompetent adults who presented within 24 hours of the onset of chickenpox rash. Incremental costs for aciclovir compared with no antiviral treatment were $US42 900 per QALY gained, when viewed from a third-party payer perspective; however, results are sensitive to variation of clinical parameters. From a societal perspective, aciclovir therapy was cost saving compared with no antiviral treatment; aciclovir remained cost saving or cost effective (less than $US50 000 per QALY gained) when probabilities, quality-of-life utility values and costs were varied within clinically plausible ranges, and when other scenarios for chickenpox severity and aciclovir effectiveness were examined. From a societal perspective, oral aciclovir is cost effective, and perhaps cost saving, when given within 24 hours of rash onset in adult chickenpox. The argument for antiviral use may be less strong when viewed from the perspective of a third-party payer.",{"EN":1142},"Cost Effectiveness of Early Treatment with Oral Aciclovir in Adult Chickenpox",{"VOID":1144},"Guess HA, Broughton DD, Melton LJ, et al. Population-based studies of varicella complications. Pediatrics 1986; 78 (4 Pt 2): 723–7\nFelser JM, Freifeld A. The epidemiology, natural history, and complications of varicella. pp. 223-229. In: Straus SE, moderator. NIH conference. Varicella-zoster virus infections: biology, natural history, treatment and prevention. Ann Intern Med 1988; 108 (2): 221–37\nPreblud SR. Varicella: complications and costs. Pediatrics 1986; 78 (4 Pt 2): 728–35\nBalfour HH, Kelly JM, Suarez CS, et al. Acyclovir treatment of varicella in otherwise healthy children. J Pediatr 1990; 116 (4): 633–9\nDunkle LM, Arvin AM, Whitley RJ, et al. A controlled trial of acyclovir for chickenpox in normal children. N Engl J Med 1991; 325: 1539–44\nBalfour HH, Rotbart HA, Feldman S, et al. Acyclovir treatment of varicella in otherwise healthy adolescents. The Collaborative Acyclovir Varicella Study Group. J Pediatr 1992; 120 (4 Pt 1): 627–33\nFeder HM. Treatment of adult chickenpox with oral acyclovir. Arch Intern Med 1990; 150: 2061–5\nWallace MR, Bowler WA, Murray NB, et al. Treatment of adult varicella with oral acyclovir: a randomised, placebo-controlled trial. Ann Intern Med 1992; 117: 358–63\nAndreoni M, Canfarini M, Grint PCA, et al. A double-blind, placebo controlled trial of efficacy and safety of oral acyclovir (Zovirax) in the treatment of chickenpox in adults. Riv Eur Sci Med Farmacol 1992; 14: 63-9\nBalfour HH. Acyclovir for treatment of varicella in immunecompetentpatients. Scand J Infect Dis Suppl 1991; 80: 75-81\nWhitley RJ. Therapeutic approaches to varicella-zoster virus infections. J Infect Dis 1992; 166 (Suppl. 1): S51–57\nAnon. Controversy about chickenpox. Lancet 1992; 340: 639–40\nNasir L. Acyclovir as a public health hazard [editorial]. J Am Board Fam Pract 1993; 6: 193–5\nBrunell PA. Oral acyclovir treatment of chickenpox in normal adolescents. J Pediatr 1992; 120 (4 Pt 1): 561–2\nWeinstein MC, Fineberg HV. Clinical decision analysis. Philadelphia: WB Saunders, 1980\nGold MR, Siegel JE, Russell LB, et al. editors. Cost-effectiveness in health and medicine. New York: Oxford University Press, 1996\nSackett DL, Torrance GW. The utility of different health states as perceived by the general public. J Chronic Dis 1978; 31: 697–704\nNational Center for Health Statistics. Vital statistics of the United States, 1988. Vol. II, Mortality (Pt A). Washington: Public Health Service, 1991\nWeber DM, Pellecchia JA. Varicella pneumonia. JAMA 1965; 192: 572–3\nEisenberg JM. Clinical economics. A guide to the economic analysis of clinical practices. JAMA 1989; 262: 2879–86\nAverage wholesale price listings. First DataBank PriceAlert. San Bruno, CA: First DataBank Inc., Oct 15, 1994\nUS Department of Commerce. Statistical abstract of the United States 1995. Table 673. Washington DC: US Government Printing Office, 1995\nWong JB, Sonnenberg FA, Salem DN, et al. Myocardial revascularisation for chronic stable angina: analysis of the role of percutaneous transluminal angioplasty based on data available in 1989. Ann Intern Med 1990; 113: 852–71\nStason WB, Weinstein MC. Allocation of resources to manage hypertension. N Engl J Med 1977; 296: 732–9\nHay JW, Wittels EH, Gotto AM. An economic evaluation of lovastatin for cholesterol lowering and coronary artery disease reduction. Am J Cardiol 1991; 67: 789–96\nDorsky DI, Crumpacker CS. Drugs five years later: acyclovir. Ann Intern Med 1987; 107: 859–74\nJacobson MA, Berger TG, Fikrig S, et al. Acyclovir-resistant varicella zoster virus infection after chronic acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1990; 112: 187–91\nSafrin S, Berger TG, Gilson I, et al. Foscarnet therapy in five patients with AIDS and acyclovir-resistant varicella-zoster virus infections. Ann Intern Med 1991; 115: 19–21\nAmerican Academy of Pediatrics Committee on Infectious Diseases. The use of oral acyclovir in otherwise healthy children with varicella. Pediatrics 1993; 91: 674–6\nEnglund JA, Arvin AM, Balfour HH. Acyclovir treatment for varicella does not lower gpI and IE-62 (p170) antibody responses to varicella-zoster virus in normal children. J Clin Microbiol 1990; 28: 2327–30\nWeibel RE, Neff BJ, Kuter BJ, et al. Live attenuated varicella virus vaccine: efficacy trial in healthy children. N Engl J Med 1984; 310: 1409–15\nGershon AA, Steinberg SP, LaRussa P, et al. Immunization of healthy adults with live attenuated varicella vaccine. 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to: Cost Effectiveness of Budesonide\u002FFormoterol Added to Tiotropium Bromide versus Placebo Added to Tiotropium Bromide in Patients with Chronic Obstructive Pulmonary Disease",{"VOID":1255},"10.1007\u002FBF03262358","Author affiliation is blank","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF03262358",[1259,1266,1273,1280,1287],{"id":1260,"sortIndex":32,"researcher":28,"roles":1261,"affiliations":1262,"properties":1263,"displayName":1265,"givenName":28,"familyName":28},"cf1ea124-1631-42ba-8572-4ef692dfb7c8",[995],[],{"title":1264},{"VI":1265},"Nicole Mittmann",{"id":1267,"sortIndex":40,"researcher":28,"roles":1268,"affiliations":1269,"properties":1270,"displayName":1272,"givenName":28,"familyName":28},"0753039d-c025-4c6c-9be9-156360198f7f",[995],[],{"title":1271},{"VI":1272},"Paul Hernandez",{"id":1274,"sortIndex":123,"researcher":28,"roles":1275,"affiliations":1276,"properties":1277,"displayName":1279,"givenName":28,"familyName":28},"15c53b3f-0f0a-4d67-8521-78187bb4cb0f",[995],[],{"title":1278},{"VI":1279},"Carl Mellström",{"id":1281,"sortIndex":42,"researcher":28,"roles":1282,"affiliations":1283,"properties":1284,"displayName":1286,"givenName":28,"familyName":28},"49954ae3-12ef-424a-93bd-5a1724f54404",[995],[],{"title":1285},{"VI":1286},"Lance Brannman",{"id":1288,"sortIndex":45,"researcher":28,"roles":1289,"affiliations":1290,"properties":1291,"displayName":1293,"givenName":28,"familyName":28},"669e2887-9b6b-49e9-97e2-d15530405ff0",[995],[],{"title":1292},{"VI":1293},"Tobias Welte",{"url":1257,"publisher":1295,"properties":1352},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1296,"slug":872,"properties":1297,"entityType":25,"verifyStatus":879,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1301,"manageAffiliations":1314,"indexDatabases":1325,"url":962,"thumbnailPath":28,"statistic":1347,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1298,"title":1299,"eissn":1300},{"VOID":875},{"EN":872},{"VOID":878},[1302,1306,1310],{"id":882,"createTime":28,"updateTime":28,"relativeEntities":1303,"label":1304,"description":1305,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":885},{},{"id":888,"createTime":28,"updateTime":28,"relativeEntities":1307,"label":1308,"description":1309,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":891},{},{"id":894,"createTime":28,"updateTime":28,"relativeEntities":1311,"label":1312,"description":1313,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":897},{},[1315,1320],{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1316,"slug":28,"properties":1317,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1319,"statistic":28},[],{"title":1318},{"EN":905},[],{"id":908,"createTime":28,"updateTime":28,"relativeEntities":1321,"slug":28,"properties":1322,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1324,"statistic":28},[],{"title":1323},{"EN":912},[],[1326,1333,1340],{"id":916,"indexDatabase":1327,"url":922,"indexYears":923,"academicFieldIds":1332,"indexDatabaseRanking":928},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1328,"label":1329,"description":1330,"key":781,"publicationTags":1331,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[925,926,927],{"id":930,"indexDatabase":1334,"url":942,"indexYears":28,"academicFieldIds":1339,"indexDatabaseRanking":28},{"id":932,"createTime":28,"updateTime":28,"relativeEntities":1335,"label":1336,"description":1337,"key":939,"publicationTags":1338,"standard":28},[],{"EN":935,"VI":935},{"EN":937,"VI":938},[941,813],[944,945],{"id":947,"indexDatabase":1341,"url":942,"indexYears":28,"academicFieldIds":1346,"indexDatabaseRanking":28},{"id":949,"createTime":28,"updateTime":28,"relativeEntities":1342,"label":1343,"description":1344,"key":956,"publicationTags":1345,"standard":28},[],{"EN":952,"VI":952},{"EN":954,"VI":955},[958,813],[960,961],{"impactFactor":32,"impactFactorByYear":1348,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":352,"totalPublicationByYear":1349,"totalCitation":32,"totalCitationByYear":1350,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1351,"hindexLast5Year":32,"hindex":32},{},{"2012":127,"2013":40,"2014":42,"2015":123,"2017":40,"2018":40,"2019":42,"2020":123,"2021":123,"2024":40},{},{},{"pages":1353,"volume":1355},{"VOID":1354},"414-414",{"VOID":1356},"29","2012-12-23",[941,958,928],{"id":1360,"createTime":1361,"updateTime":1362,"relativeEntities":1363,"slug":1364,"properties":1365,"entityType":987,"verifyStatus":26,"verifyTime":1362,"verifyNote":988,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1374,"fullTextUrl":28,"authors":1375,"publicationType":1062,"publisherRelationship":1448,"citationCount":28,"citationInfo":28,"publishDate":1511,"publishYear":1512,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":1513,"openAccess":28,"references":28,"isForceReanalyzing":1131},"005fa477-c6f5-488b-9c85-e3804f475329","2023-12-04T03:15:30.571+00:00","2025-01-16T13:35:56.438+00:00",[],"Current-Practices-for-Accounting-for-Preference-Heterogeneity-in-Health-Related-Discrete-Choice-Experiments-A-Systematic-Review",{"abstract":1366,"title":1368,"references":1370,"doi":1372},{"EN":1367},"Accounting for preference heterogeneity is a growing analytical practice in health-related discrete choice experiments (DCEs). As heterogeneity may be examined from different stakeholder perspectives with different methods, identifying the breadth of these methodological approaches and understanding the differences are major steps to provide guidance on good research practices. Our objective was to systematically summarize current practices that account for preference heterogeneity based on the published DCEs related to healthcare. This systematic review is part of the project led by the Professional Society for Health Economics and Outcomes Research (ISPOR) health preference research special interest group. The systematic review conducted systematic searches on the PubMed, OVID, and Web of Science databases, as well as on two recently published reviews, to identify articles. The review included health-related DCE articles published between 1 January 2000 and 30 March 2020. All the included articles also presented evidence on preference heterogeneity analysis based on either explained or unexplained factors or both. Overall, 342 of the 2202 (16%) articles met the inclusion\u002Fexclusion criteria for extraction. The trend showed that analyses of preference heterogeneity increased substantially after 2010 and that such analyses mainly examined heterogeneity due to observable or unobservable factors in individual characteristics. Heterogeneity through observable differences (i.e., explained heterogeneity) is identified among 131 (40%) of the 342 articles and included one or more interactions between an attribute variable and an observable characteristic of the respondent. To capture unobserved heterogeneity (i.e., unexplained heterogeneity), the studies largely estimated either a mixed logit (n = 205, 60%) or a latent-class logit (n = 112, 32.7%) model. Few studies (n = 38, 11%) explored scale heterogeneity or heteroskedasticity. Providing preference heterogeneity evidence in health-related DCEs has been found as an increasingly used practice among researchers. In recent studies, controlling for unexplained preference heterogeneity has been seen as a common practice rather than explained ones (e.g., interactions), yet a lack of providing methodological details has been observed in many studies that might impact the quality of analysis. As heterogeneity can be assessed from different stakeholder perspectives with different methods, researchers should become more technically pronounced to increase confidence in the results and improve the ability of decision makers to act on the preference evidence.",{"EN":1369},"Current Practices for Accounting for Preference Heterogeneity in Health-Related Discrete Choice Experiments: A Systematic Review",{"VOID":1371},"Zhou M, Thayer WM, Bridges JFP. Using latent class analysis to model preference heterogeneity in health: a systematic review. 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An exploration of the potential impact of cognitive functioning in discrete choice experiments with older people in health care. Value Health. 2014;17:655–9.\nHuber J, Train K. On the similarity of classical and Bayesian estimates of individual mean partworths. Mark Lett. 2001;12:259–69.",{"VOID":1373},"10.1007\u002Fs40273-022-01178-y","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs40273-022-01178-y",[1376,1394,1409,1433],{"id":1377,"sortIndex":32,"researcher":28,"roles":1378,"affiliations":1379,"properties":1391,"displayName":1393,"givenName":28,"familyName":28},"2967288b-3aec-4086-beeb-ba97ce0ca95f",[995],[1380],{"id":1381,"sortIndex":32,"affiliation":1382,"properties":1388},"75e53506-e711-48af-a964-8e7c31fb9c0c",{"id":1381,"createTime":28,"updateTime":28,"relativeEntities":1383,"slug":28,"properties":1384,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1387,"statistic":28},[],{"title":1385},{"VI":1386},"University of South Florida, Tampa, United States",[],{"title":1389},{"VI":1390},"University of South Florida, Tampa, USA",{"title":1392},{"VI":1393},"Suzana Karim",{"id":1395,"sortIndex":40,"researcher":28,"roles":1396,"affiliations":1397,"properties":1406,"displayName":1408,"givenName":28,"familyName":28},"f8fecf21-1f39-4830-b297-57efe0b8edec",[995],[1398],{"id":1381,"sortIndex":32,"affiliation":1399,"properties":1404},{"id":1381,"createTime":28,"updateTime":28,"relativeEntities":1400,"slug":28,"properties":1401,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1403,"statistic":28},[],{"title":1402},{"VI":1386},[],{"title":1405},{"VI":1390},{"title":1407},{"VI":1408},"Benjamin M. 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Several self-report productivity instruments have been designed over the past few years to measure the impact of illness on productivity at work and\u002For in non-work activities. In a review of the literature we identified six generic subjective instruments — the Endicott Work Productivity Scale, Health and Labor Questionnaire, Health and Work Questionnaire, Health and Work Performance Questionnaire, Work Limitations Questionnaire (WLQ) and the Work Productivity and Activity Impairment Questionnaire (WPAI) — that could theoretically be used in any working population. These instruments were usually validated against other subjective measures (such as health-related QOL). Each productivity instrument has benefits in certain research settings, but the psychometric properties of the WPAI have been assessed most extensively. It was the most frequently used instrument and has also been modified to measure productivity reductions associated with specific diseases (e.g. allergic rhinitis, gastro-oesophageal reflux disease, chronic hand dermatitis). The WLQ has also been tested extensively to measure the general health impact and impact of specific conditions. Two migraine-specific subjective instruments were also identified: the Migraine Disability Assessment questionnaire and the Migraine Work and Productivity Loss Questionnaire, of which the latter was found to have better psychometric properties. Productivity outcomes are useful in that they characterise the impact of an illness in the workplace and show the effect of treatment on productivity. Evidence of psychometric properties and generalisability of different instruments was found to a varying degree. Thus, further research is needed to assess the accuracy and usefulness of individual instruments in certain research settings. Health-related productivity has been increasingly recognised as an important component of the burden of illness associated with a given disease; without it, one cannot reliably assess this burden.\n",{"EN":1617},"A Review of Self-Report Instruments Measuring Health-Related Work Productivity",{"VOID":1619},"Gold MR. Cost-effectiveness in health and medicine. New York: Oxford University Press, 1996\nLerner DJ, Amick III BC, Malspeis S, et al. A national survey of health-related work limitations among employed persons in the United States. Disabil Rehabil 2000; 22 (5): 225–32\nWare J. SF-36 health study: manual and interpretation guide. Boston (MA): Health Outcomes Trust, 1993\nShumaker S, Anderson R. Psychological tests and scales. In: Spilker B, editor. Quality of life assessments in clinical trials. New York: Raven Press, 1990: 95–113\nJuniper E, Guyatt G, Jaeschke R. How to develop and validate a new health-related quality of life instrument. In: Spilker B, editor. Quality of life and pharmacoeconomics in clinical trials. Philadelphia (PA): Lippincott-Raven Publishers, 1996: 49–56\nBrazier J, Deverill M. A checklist for judging preference-based measures of health related quality of life: learning from psychometrics. Health Econ 1999; 8 (1): 41–51\nMcDowell I, Newell C. Measuring health: a guide to rating scales and questionnaires. 2nd ed. New York: Oxford University Press, 1996\nBowling A. Measuring health: a review of quality of life measurement scales. 2nd ed. Buckingham (PA): Open University Press, 1997\nNunnally JC, Bernstein IH. Psychometric theory. New York (NY): McGraw Hill, 1994\nHays R, Anderson R. Assessing reliability and validity of measurement in clinical trials. In: Staquet M, Hays R, Fayers P. Quality of life assessment in clinical trials: methods and practice. Oxford: Oxford University Press, 1998\nSudman S, Bradburn NM, Schwarz N. Thinking about answers: the application of cognitive processes to survey methodology. San Francisco (CA): Jossey-Bas Publishers, 1996\nMuldoon MF, Barger SC, Flory JD, et al. What are quality of life measurements measuring? BMJ 1998; 316: 542–5\nBurke L, Piault E. Patient-reported measures in drug development: FDA perspective. In: Chassany C, Caulin C. Healthrelated quality of life and patient-reported outcomes: scientific and useful outcome criteria. Paris: Springer-Verlag, 2003: 117–22\nStewart WF, Ricci J, Leotta CR, et al. Self-report of healthrelated lost productivity work time: bias and the optimal recall period [abstract]. Value Health 2001; 4: A421\nEndicott J, Nee J. Endicott Work Productivity Scale (EWPS): a new measure to assess treatment effects. Psychopharmacol Bull 1997; 33 (1): 13–6\nvan Roijen L, Essink-Bot ML, Koopmanschap MA, et al. Labor and health status in economic evaluation of health care: the health and labor questionnaire. Int J Technol Assess Health Care 1996; 12 (3): 405–15\nKessler RC, Barber C, Beck A, et al. The World Health Organization health and work performance questionnaire (HPQ). J Occup Environ Med 2003; 45: 156–74\nHalpern MT, Shikiar R, Rentz AM, et al. Impact of smoking status on workplace absenteeism and productivity. Tob Control 2001; 10 (3): 233–8\nLerner D, Amick III BC, Rogers WH, et al. The work limitations questionnaire. Med Care 2001; 39 (1): 72–85\nReilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993; 4 (5): 353–65\nReilly M, Tanner A, Meltzer EO. Work, classroom, and activity impairment instruments: validation studies in allergic rhinitis. Clin Drug Invest 1996; 11 (5): 278–88\nWahlqvist P, Carlsson J, Stalhammar NO, et al. Validity of a work productivity and activity impairment questionnaire for patients with symptoms of gastro-esophageal reflux disease (WPAI-GERD): results from a cross-sectional study. Value Health 2002; 5 (2): 106–13\nReilly MC, Lavin PT, Kahler KH, et al. Validation of the dermatology life quality index and the work productivity and activity impairment-chronic hand dermatitis questionnaire in chronic hand dermatitis. J Am Acad Dermatol 2003; 48 (1): 128–30\nStewart WF, Lipton RB, Kolodner K, et al. Reliability of the migraine disability assessment score in a population-based sample of headache sufferers. Cephalalgia 1999; 19 (2): 107–14\nStewart WF, Lipton RB, Kolodner KB, et al. Validity of the migraine disability assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers. Pain 2000; 88 (1): 41–52\nLerner DJ, Amick III BC, Malspeis S, et al. The migraine work and productivity loss questionnaire: concepts and design. Qual Life Res 1999; 8 (8): 699–710\nDavies GM, Santanello N, Gerth W, et al. Validation of a migraine work and productivity loss questionnaire for use in migraine studies. Cephalalgia 1999; 19 (5): 497–502\nChirban JT, Jacobs RJ, Warren J, et al. The 36-item short form health survey (SF-36) and the work productivity and activity impairment (WPAI) questionnaire in panic disorder. Dis Manage Health Outcomes 1997; 1 (3): 154–64\nLerner D, Reed JI, Massarotti E, et al. The work limitations questionnaire’s validity and reliability among patients with osteoarthritis. J Clin Epidemiol 2002; 55 (2): 197–208\nOsterhaus JT, Gutterman DL, Plachetka JR. Healthcare resource and lost labour costs of migraine headache in the US. Pharmacoeconomics 1992; 2 (1): 67–76\nKoopmanschap MA, van Ineveld BM. Towards a new approach for estimating indirect costs of disease. Soc Sci Med 1992; 34 (9): 1005–10\nKoopmanschap MA, Rutten FF. The impact of indirect costs on outcomes of health care programs. Health Econ 1994; 3 (6): 385–93\nBrouwer WB, Koopmanschap MA, Rutten FF. Productivity costs measurement through quality of life?: a response to the recommendation of the Washington panel. Health Econ 1997; 6 (3): 253–9\nEttigi P, Meyerhoff AS, Chirban JT, et al. The quality of life and employment in panic disorder. J Nerv Ment Dis 1997; 185 (6): 368–72\nMeltzer EO, Casale TB, Nathan RA, et al. Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 1999; 83 (4): 311–7\nThompson AK, Finn AF, Schoenwetter WF. Effect of 60mg twice-daily fexofenadine HCl on quality of life, work and classroom productivity, and regular activity in patients with chronic idiopathic urticaria. J Am Acad Dermatol 2000; 43 (1 Pt 1): 24–30\nJacobs RJ, Davidson JR, Gupta S, et al. The effects of clonazepam on quality of life and work productivity in panic disorder. Am J Manag Care 1997; 3 (8): 1187–96\nTanner L, Reilly M, Meltzer EO, et al. Effect of fexofenadine HCl on quality of life and work, classroom and daily activity impairment in patients with seasonal allergic rhinitis. Am J Manag Care 1999; 5 Suppl. 4: S235–47\nWittchen HU, Beloch E. The impact of social phobia on quality of life. Int Clin Psychopharmacol 1996; 11 Suppl. 3: 15–23\nDean BB, Crawley JA, Schmitt CM, et al. The burden of illness of gastro-oesophageal reflux disease: impact on work productivity. Aliment Pharmacol Ther 2003; 17: 1309–17\nBurke LB. US regulation of pharmaceutical outcomes research. Value Health 2001; 4 (1): 5–7\nMorris LA, Miller DW. The regulation of patient-reported outcome claims: need for a flexible standard. Value Health 2002; 5 (4): 372–81\nRadensky P. Regulation of pharmacoeconomics and outcomes research. Value Health 2001; 4 (1): 12–5\nBerndt ER, Bailit HL, Keller MB, et al. Health care use and atwork productivity among employees with mental disorders. Health Aff (Millwood) 2000; 19 (4): 244–56\nBurton WN, Conti DJ, Chen CY, et al. The role of health risk factors and disease on worker productivity. J Occup Environ Med 1999; 41 (10): 863–77\nBurton WN, Conti DJ, Chen CY, et al. The impact of allergies and allergy treatment on worker productivity. J Occup Environ Med 2001; 43 (1): 64–71\nLandy FJ, Farr JL. The measurement of work performance: methods, theory, and applications. New York: Academic Press, 1983\nLerner D, Amick BC, Lee JC, et al. Relationship of employeereported work limitations to work productivity. Med Care 2003; 41 (5): 649–59\nBerger ML, Murray JF, Xu J, et al. Alternative valuations of work loss and productivity. J Occup Environ Med 2001; 43 (1): 18–24\nLynch W, Riedel JE, editors. Measuring employee productivity: a guide to self-assessment tools. 2001 ed. Scottsdale (AZ): Institute for Health and Productivity Management, 2001",{"VOID":1621},"10.2165\u002F00019053-200422040-00002","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.2165\u002F00019053-200422040-00002",[1624,1639,1654,1669],{"id":1625,"sortIndex":32,"researcher":28,"roles":1626,"affiliations":1627,"properties":1636,"displayName":1638,"givenName":28,"familyName":28},"4e1f8cc1-f5a9-4258-a721-bd1c6a3d82a1",[995],[1628],{"id":1629,"sortIndex":32,"affiliation":1630,"properties":28},"428f2ad0-1323-4c51-8ff6-70be8902b42f",{"id":1629,"createTime":28,"updateTime":28,"relativeEntities":1631,"slug":28,"properties":1632,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1635,"statistic":28},[],{"title":1633},{"VI":1634},"MEDTAP International, Inc, Bethesda, USA",[],{"title":1637},{"VI":1638},"Manishi Prasad",{"id":1640,"sortIndex":40,"researcher":28,"roles":1641,"affiliations":1642,"properties":1651,"displayName":1653,"givenName":28,"familyName":28},"556b0a7b-c3cd-4c6e-9432-9628b2312f48",[995],[1643],{"id":1644,"sortIndex":32,"affiliation":1645,"properties":28},"51c85bbe-9d13-4010-9dee-47cbef08086a",{"id":1644,"createTime":28,"updateTime":28,"relativeEntities":1646,"slug":28,"properties":1647,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1650,"statistic":28},[],{"title":1648},{"VI":1649},"AstraZeneca R&D Mölndal, Mölndal, Sweden",[],{"title":1652},{"VI":1653},"Peter Wahlqvist",{"id":1655,"sortIndex":123,"researcher":28,"roles":1656,"affiliations":1657,"properties":1666,"displayName":1668,"givenName":28,"familyName":28},"5e39e39f-ef9f-4fce-85f3-60f1c69dc6ec",[995],[1658],{"id":1659,"sortIndex":32,"affiliation":1660,"properties":28},"e4d40997-4b74-41fb-90ae-a41675f3d3af",{"id":1659,"createTime":28,"updateTime":28,"relativeEntities":1661,"slug":28,"properties":1662,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1665,"statistic":28},[],{"title":1663},{"VI":1664},"MEDTAP International, Inc., Seattle, USA",[],{"title":1667},{"VI":1668},"Rich Shikiar",{"id":1670,"sortIndex":42,"researcher":28,"roles":1671,"affiliations":1672,"properties":1681,"displayName":1683,"givenName":28,"familyName":28},"225df05b-4a3f-4783-913e-78d6e9febda3",[995],[1673],{"id":1674,"sortIndex":32,"affiliation":1675,"properties":28},"ca7d9d69-2558-412b-af5a-71e77565ee06",{"id":1674,"createTime":28,"updateTime":28,"relativeEntities":1676,"slug":28,"properties":1677,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1680,"statistic":28},[],{"title":1678},{"VI":1679},"The University of Texas M. D. Anderson Cancer Center, Houston, USA",[],{"title":1682},{"VI":1683},"Ya-Chen Tina Shih",{"url":1622,"publisher":1685,"properties":1742},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1686,"slug":872,"properties":1687,"entityType":25,"verifyStatus":879,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1691,"manageAffiliations":1704,"indexDatabases":1715,"url":962,"thumbnailPath":28,"statistic":1737,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1688,"title":1689,"eissn":1690},{"VOID":875},{"EN":872},{"VOID":878},[1692,1696,1700],{"id":882,"createTime":28,"updateTime":28,"relativeEntities":1693,"label":1694,"description":1695,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":885},{},{"id":888,"createTime":28,"updateTime":28,"relativeEntities":1697,"label":1698,"description":1699,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":891},{},{"id":894,"createTime":28,"updateTime":28,"relativeEntities":1701,"label":1702,"description":1703,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":897},{},[1705,1710],{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1706,"slug":28,"properties":1707,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1709,"statistic":28},[],{"title":1708},{"EN":905},[],{"id":908,"createTime":28,"updateTime":28,"relativeEntities":1711,"slug":28,"properties":1712,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1714,"statistic":28},[],{"title":1713},{"EN":912},[],[1716,1723,1730],{"id":916,"indexDatabase":1717,"url":922,"indexYears":923,"academicFieldIds":1722,"indexDatabaseRanking":928},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1718,"label":1719,"description":1720,"key":781,"publicationTags":1721,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[925,926,927],{"id":930,"indexDatabase":1724,"url":942,"indexYears":28,"academicFieldIds":1729,"indexDatabaseRanking":28},{"id":932,"createTime":28,"updateTime":28,"relativeEntities":1725,"label":1726,"description":1727,"key":939,"publicationTags":1728,"standard":28},[],{"EN":935,"VI":935},{"EN":937,"VI":938},[941,813],[944,945],{"id":947,"indexDatabase":1731,"url":942,"indexYears":28,"academicFieldIds":1736,"indexDatabaseRanking":28},{"id":949,"createTime":28,"updateTime":28,"relativeEntities":1732,"label":1733,"description":1734,"key":956,"publicationTags":1735,"standard":28},[],{"EN":952,"VI":952},{"EN":954,"VI":955},[958,813],[960,961],{"impactFactor":32,"impactFactorByYear":1738,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":352,"totalPublicationByYear":1739,"totalCitation":32,"totalCitationByYear":1740,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1741,"hindexLast5Year":32,"hindex":32},{},{"2012":127,"2013":40,"2014":42,"2015":123,"2017":40,"2018":40,"2019":42,"2020":123,"2021":123,"2024":40},{},{},{"pages":1743,"volume":1745},{"VOID":1744},"225-244",{"VOID":1746},"22","2012-09-22",[941,958,928],{"id":1750,"createTime":1751,"updateTime":1752,"relativeEntities":1753,"slug":1754,"properties":1755,"entityType":987,"verifyStatus":26,"verifyTime":1752,"verifyNote":988,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1764,"fullTextUrl":28,"authors":1765,"publicationType":1062,"publisherRelationship":1861,"citationCount":28,"citationInfo":28,"publishDate":1924,"publishYear":1925,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":1926,"openAccess":28,"references":28,"isForceReanalyzing":1131},"012e684b-26cb-47c9-b541-68178a258b71","2023-12-26T15:57:28.633+00:00","2025-02-26T21:47:02.642+00:00",[],"Family-and-Caregiver-Spillover-Effects-in-Cost-Utility-Analyses-of-Alzheimer-s-Disease-Interventions",{"abstract":1756,"title":1758,"references":1760,"doi":1762},{"EN":1757},"Alzheimer’s disease or dementia can impose a significant burden on family and other informal caregivers. This study investigated how the inclusion of family\u002Finformal caregiver spillover effects in a cost-utility analysis may influence the reported value of Alzheimer’s disease\u002Fdementia interventions. We used PubMed to identify Alzheimer’s disease or dementia cost-utility analyses published from 1 January, 2000 to 31 March, 2018. We reviewed and abstracted information from each study using a two-reader consensus process. We investigated the frequency and methods in which family\u002Fcaregiver spillover costs and health effects were incorporated into cost-utility analyses, and examined how their inclusion may influence the reported incremental cost-effectiveness ratios. Of 63 Alzheimer’s disease\u002Fdementia cost-utility analyses meeting inclusion criteria, 44 (70%) considered at least some family\u002Fcaregiver spillover costs or health effects. Thirty-two studies incorporated spillover costs only, two incorporated spillover health effects only, and ten incorporated both. The most common approach for accounting for spillover was adding informal caregiving time costs to patient costs (n = 36) and adding informal caregiver quality-adjusted life-years to patient values (n = 7). In a subset of 33 incremental cost-effectiveness ratio pairs from 19 studies, incorporating spillover outcomes made incremental cost-effectiveness ratios more favorable (n = 15; 45%) or kept the intervention cost saving (n = 13; 39%) in most cases. In fewer cases, including spillover increased incremental cost-effectiveness ratios (n = 2; 6%), kept the intervention dominated [more costs\u002Fless quality-adjusted life-years] (n = 2; 6%), or changed incremental cost-effectiveness ratio from dominated to less cost\u002Fless quality-adjusted life-years (n = 1; 3%). In 11 cases (33%), adding spillover effects into analyses resulted in a lower incremental cost-effectiveness ratio that crossed a common cost-effectiveness threshold, which could have downstream implications for programs or policies that are adopted based on cost-effectiveness analysis results. Most Alzheimer’s disease\u002Fdementia cost-utility analyses incorporated spillover costs, often as caregiver time costs, but considered spillover health impacts less often. In about 85% of the analyses, including Alzheimer’s disease\u002Fdementia spillover cost or health effects decreased incremental cost-effectiveness ratios or kept the intervention cost saving. The broader value of an Alzheimer’s disease\u002Fdementia intervention to society may in some cases be underestimated without considering these spillover effects on family and informal caregivers.",{"EN":1759},"Family and Caregiver Spillover Effects in Cost-Utility Analyses of Alzheimer’s Disease Interventions",{"VOID":1761},"Langa KM, Chernew ME, Kabeto MU, Herzog AR, Ofstedal MB, Willis RJ, et al. National estimates of the quantity and cost of informal caregiving for the elderly with dementia. J Gen Intern Med. 2001;16(11):770–8.\nMoore MJ, Zhu CW, Clipp EC. Informal costs of dementia care: estimates from the National Longitudinal Caregiver Study. J Gerontol B Psychol Sci Soc Sci. 2001;56(4):S219–28.\nSchulz R, Martire LM. Family caregiving of persons with dementia: prevalence, health effects, and support strategies. Am J Geriatr Psychiatry. 2004;12(3):240–9.\nAssociation Alzheimer’s. 2017 Alzheimer’s disease facts and figures. Alzheimers Dement. 2017;13(4):325–73.\nNAC and AARP. Caregiving in the U.S. June 2015. The National Alliance for Caregiving, Bethesda, MD and the AARP Public Policy Institute, Washington DC.\nNational Alliance for Caregiving in Partnership with the Alzheimer’s Association. Dementia caregiving in the U.S. Bethesda, MD. 2017. http:\u002F\u002Fwww.caregiving.org\u002Fwp-content\u002Fuploads\u002F2014\u002F01\u002FDementia-Caregiving-in-the-US_February-2017.pdf. Accessed 3 Mar 2019.\nCovinsky KE, Newcomer R, Fox P, Wood J, Sands L, Dane K, et al. Patient and caregiver characteristics associated with depression in caregivers of patients with dementia. J Gen Intern Med. 2003;18(12):1006–14.\nCrespo M, Lopez J, Zarit SH. Depression and anxiety in primary caregivers: a comparative study of caregivers of demented and nondemented older persons. Int J Geriatr Psychiatry. 2005;20(6):591–2. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fgps.1321.\nKim Y, Schulz R. 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Curr Med Res Opin. 2007;23(5):1187–97. https:\u002F\u002Fdoi.org\u002F10.1185\u002F030079907X188071.\nWillan AR, Goeree R, Pullenayegum EM, McBurney C, Blackhouse G. Economic evaluation of rivastigmine in patients with Parkinson’s disease dementia. Pharmacoeconomics. 2006;24(1):93–106.\nWolfs CA, Dirksen CD, Kessels A, Severens JL, Verhey FR. Economic evaluation of an integrated diagnostic approach for psychogeriatric patients: results of a randomized controlled trial. Arch Gen Psychiatry. 2009;66(3):313–23. https:\u002F\u002Fdoi.org\u002F10.1001\u002Farchgenpsychiatry.2008.544.\nWoods RT, Orrell M, Bruce E, Edwards RT, Hoare Z, Hounsome B, et al. REMCARE: pragmatic multi-centre randomised trial of reminiscence groups for people with dementia and their family carers: effectiveness and economic analysis. PLoS One. 2016;11(4):e0152843. https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0152843.\nYang KC, Chen HH. Probabilistic cost-effectiveness analysis of vaccination for mild or moderate Alzheimer’s disease. Curr Alzheimer Res. 2016;13(7):809–16.\nYu SY, Lee TJ, Jang SH, Han JW, Kim TH, Kim KW. Cost-effectiveness of nationwide opportunistic screening program for dementia in South Korea. J Alzheimers Dis. 2015;44(1):195–204. https:\u002F\u002Fdoi.org\u002F10.3233\u002FJAD-141632.\nZhang Y, Kivipelto M, Solomon A, Wimo A. Cost-effectiveness of a health intervention program with risk reductions for getting demented: results of a Markov model in a Swedish\u002FFinnish setting. J Alzheimers Dis. 2011;26(4):735–44. https:\u002F\u002Fdoi.org\u002F10.3233\u002FJAD-2011-110065.\nZwijsen SA, Bosmans JE, Gerritsen DL, Pot AM, Hertogh CM, Smalbrugge M. The cost-effectiveness of grip on challenging behaviour: an economic evaluation of a care programme for managing challenging behaviour. Int J Geriatr Psychiatry. 2016;31(6):567–74. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fgps.4360.\nBrown H, D’Amico F, Knapp M, Orrell M, Rehill A, Vale L, et al. A cost effectiveness analysis of maintenance cognitive stimulation therapy (MCST) for people with dementia: examining the influence of cognitive ability and living arrangements. Aging Ment Health. 2018:1–6. https:\u002F\u002Fdoi.org\u002F10.1080\u002F13607863.2018.1442410.\nGomes M, Pennington M, Wittenberg R, Knapp M, Black N, Smith S. Cost-effectiveness of memory assessment services for the diagnosis and early support of patients with dementia in England. J Health Serv Res Policy. 2017;22(4):226–35. https:\u002F\u002Fdoi.org\u002F10.1177\u002F1355819617714816.\nHandels RLH, Wimo A, Dodel R, Kramberger MG, Visser PJ, Molinuevo JL, et al. Cost-utility of using Alzheimer’s disease biomarkers in cerebrospinal fluid to predict progression from mild cognitive impairment to dementia. 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National Alliance for Caregiving, Bethesda, MD.\nBobinac A, van Exel NJ, Rutten FF, Brouwer WB. Health effects in significant others: separating family and care-giving effects. Med Decis Mak. 2011;31(2):292–8. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0272989x10374212.\nLavelle TA, Wittenberg E, Lamarand K, Prosser LA. Variation in the spillover effects of illness on parents, spouses, and children of the chronically ill. Appl Health Econ Health Policy. 2014;12(2):117–24. https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs40258-014-0079-8.\nAl-Janabi H, Van Exel J, Brouwer W, Trotter C, Glennie L, Hannigan L, et al. Measuring health spillovers for economic evaluation: a case study in meningitis. Health Econ. 2016;25(12):1529–44. https:\u002F\u002Fdoi.org\u002F10.1002\u002Fhec.3259.\nReed C, Belger M, Dell’agnello G, Wimo A, Argimon JM, Bruno G, et al. Caregiver burden in Alzheimer’s disease: differential associations in adult-child and spousal caregivers in the GERAS observational study. Dement Geriatr Cogn Dis Extra. 2014;4(1):51–64. https:\u002F\u002Fdoi.org\u002F10.1159\u002F000358234.\nGoodrich K, Kaambwa B, Al-Janabi H. The inclusion of informal care in applied economic evaluation: a review. Value Health. 2012;15(6):975–81. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jval.2012.05.009.\nBrazier J, Connell J, Papaioannou D, Mukuria C, Mulhern B, Peasgood T, et al. A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures. Health Technol Assess. 2014;18(34):vii–viii, xiii–xxv, 1–188. https:\u002F\u002Fdoi.org\u002F10.3310\u002Fhta18340.\nZhu CW, Leibman C, McLaughlin T, Scarmeas N, Albert M, Brandt J, et al. The effects of patient function and dependence on costs of care in Alzheimer’s disease. J Am Geriatr Soc. 2008;56(8):1497–503. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1532-5415.2008.01798.x.\nLavelle TA, Kent DM, Lundquist CM, Thorat T, Cohen JT, Wong JB, et al. Patient variability seldom assessed in cost-effectiveness studies. Med Decis Mak. 2018;38(4):487–94. https:\u002F\u002Fdoi.org\u002F10.1177\u002F0272989x17746989.\nSchulz R, Mendelsohn AB, Haley WE, Mahoney D, Allen RS, Zhang S, et al. End-of-life care and the effects of bereavement on family caregivers of persons with dementia. N Engl J Med. 2003;349(20):1936–42. https:\u002F\u002Fdoi.org\u002F10.1056\u002FNEJMsa035373.\nBrouwer WB, van Exel NJ, Koopmanschap MA, Rutten FF. The valuation of informal care in economic appraisal: a consideration of individual choice and societal costs of time. Int J Technol Assess Health Care. 1999;15(1):147–60.\nNeumann PJ, Thorat T, Shi J, Saret CJ, Cohen JT. The changing face of the cost-utility literature, 1990–2012. Value Health. 2015;18(2):271–7. https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jval.2014.12.002.",{"VOID":1763},"10.1007\u002Fs40273-019-00788-3","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40273-019-00788-3",[1766,1781,1794,1807,1820,1835,1848],{"id":1767,"sortIndex":32,"researcher":28,"roles":1768,"affiliations":1769,"properties":1778,"displayName":1780,"givenName":28,"familyName":28},"e10fcce7-227a-4997-a618-62467476d82e",[995],[1770],{"id":1771,"sortIndex":32,"affiliation":1772,"properties":28},"d5e43bb9-81f9-4efd-99a0-99127ed65187",{"id":1771,"createTime":28,"updateTime":28,"relativeEntities":1773,"slug":28,"properties":1774,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1777,"statistic":28},[],{"title":1775},{"VI":1776},"Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, USA",[],{"title":1779},{"VI":1780},"Pei-Jung Lin",{"id":1782,"sortIndex":40,"researcher":28,"roles":1783,"affiliations":1784,"properties":1791,"displayName":1793,"givenName":28,"familyName":28},"353f7460-95aa-4e9b-8f48-1d3a538a0ab7",[995],[1785],{"id":1771,"sortIndex":32,"affiliation":1786,"properties":28},{"id":1771,"createTime":28,"updateTime":28,"relativeEntities":1787,"slug":28,"properties":1788,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1790,"statistic":28},[],{"title":1789},{"VI":1776},[],{"title":1792},{"VI":1793},"Brittany D’Cruz",{"id":1795,"sortIndex":123,"researcher":28,"roles":1796,"affiliations":1797,"properties":1804,"displayName":1806,"givenName":28,"familyName":28},"6f6cae7d-0df7-49ac-84d5-2cc64153b963",[995],[1798],{"id":1771,"sortIndex":32,"affiliation":1799,"properties":28},{"id":1771,"createTime":28,"updateTime":28,"relativeEntities":1800,"slug":28,"properties":1801,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1803,"statistic":28},[],{"title":1802},{"VI":1776},[],{"title":1805},{"VI":1806},"Ashley A. 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Lavelle",{"url":1764,"publisher":1862,"properties":1919},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":1863,"slug":872,"properties":1864,"entityType":25,"verifyStatus":879,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":1868,"manageAffiliations":1881,"indexDatabases":1892,"url":962,"thumbnailPath":28,"statistic":1914,"gsStatistic":28,"type":55,"analyzePriority":28},[],{"issn":1865,"title":1866,"eissn":1867},{"VOID":875},{"EN":872},{"VOID":878},[1869,1873,1877],{"id":882,"createTime":28,"updateTime":28,"relativeEntities":1870,"label":1871,"description":1872,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":885},{},{"id":888,"createTime":28,"updateTime":28,"relativeEntities":1874,"label":1875,"description":1876,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":891},{},{"id":894,"createTime":28,"updateTime":28,"relativeEntities":1878,"label":1879,"description":1880,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":897},{},[1882,1887],{"id":901,"createTime":28,"updateTime":28,"relativeEntities":1883,"slug":28,"properties":1884,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1886,"statistic":28},[],{"title":1885},{"EN":905},[],{"id":908,"createTime":28,"updateTime":28,"relativeEntities":1888,"slug":28,"properties":1889,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1891,"statistic":28},[],{"title":1890},{"EN":912},[],[1893,1900,1907],{"id":916,"indexDatabase":1894,"url":922,"indexYears":923,"academicFieldIds":1899,"indexDatabaseRanking":928},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":1895,"label":1896,"description":1897,"key":781,"publicationTags":1898,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[925,926,927],{"id":930,"indexDatabase":1901,"url":942,"indexYears":28,"academicFieldIds":1906,"indexDatabaseRanking":28},{"id":932,"createTime":28,"updateTime":28,"relativeEntities":1902,"label":1903,"description":1904,"key":939,"publicationTags":1905,"standard":28},[],{"EN":935,"VI":935},{"EN":937,"VI":938},[941,813],[944,945],{"id":947,"indexDatabase":1908,"url":942,"indexYears":28,"academicFieldIds":1913,"indexDatabaseRanking":28},{"id":949,"createTime":28,"updateTime":28,"relativeEntities":1909,"label":1910,"description":1911,"key":956,"publicationTags":1912,"standard":28},[],{"EN":952,"VI":952},{"EN":954,"VI":955},[958,813],[960,961],{"impactFactor":32,"impactFactorByYear":1915,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":352,"totalPublicationByYear":1916,"totalCitation":32,"totalCitationByYear":1917,"totalCitationPerPublication":32,"totalCitationPerPublicationByYear":1918,"hindexLast5Year":32,"hindex":32},{},{"2012":127,"2013":40,"2014":42,"2015":123,"2017":40,"2018":40,"2019":42,"2020":123,"2021":123,"2024":40},{},{},{"pages":1920,"volume":1922},{"VOID":1921},"597-608",{"VOID":1923},"37","2019-03-22",2019,[941,958,928],{"id":1928,"createTime":1929,"updateTime":1930,"relativeEntities":1931,"slug":1932,"properties":1933,"entityType":987,"verifyStatus":26,"verifyTime":1930,"verifyNote":988,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1942,"fullTextUrl":28,"authors":1943,"publicationType":1062,"publisherRelationship":2044,"citationCount":28,"citationInfo":28,"publishDate":2107,"publishYear":1243,"citationAnalyzeStatus":879,"lastCitationAnalyze":28,"indexDatabases":2108,"openAccess":28,"references":28,"isForceReanalyzing":1131},"01520a7b-fb2d-4592-b03c-9044d51ce64e","2024-01-09T23:57:27.437+00:00","2025-02-18T14:46:43.797+00:00",[],"Economic-Evaluation-of-the-Use-of-Nadroparin-Calcium-in-the-Prophylaxis-of-Deep-Vein-Thrombosis-and-Pulmonary-Embolism-in-Surgical-Patients-in-Italy",{"abstract":1934,"title":1936,"references":1938,"doi":1940},{"EN":1935},"The objective of this study was to compare the costs, from the perspective of the payer, of using nadroparin calcium, a low-molecular-weight heparin, instead of unfractionated heparin in the prophylaxis of venous thromboembolism in patients undergoing orthopaedic surgery or major general surgery in Italy. The methods used were based on a published meta-analysis and a survey of clinical practice. We constructed a model of the prophylaxis and management of venous thromboembolism in Italy. Resource use associated with individual events was estimated on the basis of the clinical survey. Unit costs, not available from published sources, were taken from charges made by hospitals and from direct observation. A sensitivity analysis was conducted to examine whether the results were robust to changes in key variables. In the base case, compared with unfractionated heparin, prophylaxis with nadroparin calcium reduced the expected costs of managing thromboembolism by 267 226 Italian lire (L, 1994 values; $US 1 = L1600 approx.) per patient undergoing orthopaedic surgery, and by L45 588 per patient undergoing major general surgery. Therefore, switching from unfractionated heparin to nadroparin calcium in these patients offers the possibility of significant cost savings to the Italian healthcare system.",{"EN":1937},"Economic Evaluation of the Use of Nadroparin Calcium in the Prophylaxis of Deep Vein Thrombosis and Pulmonary Embolism in Surgical Patients in Italy",{"VOID":1939},"Thromboembolic Risk Factors (THRIFT) Consensus Group. Risk of and prophylaxis for thromboembolism in hospital patients. BMJ 1992; 305: 567–74\nPrevention of venous thromboembolism: European consensus statement. Developed under the auspices of the Cardiovascular Disease Education and Research Trust; 1991 Nov 1-5; Windsor. Cyprus: Med-Orion Publishing Company, 1992\nWille-Jørgesen P. Prophylaxis of postoperative thromboembolism. Dan Med Bull 1991; 38: 203–28\nClagett GP, Reisch lS. Prevention of venous thromboembolism in general surgery patients. Ann Surg 1988; 208: 227–40\nCollins R, Scrimgeour A, Yusuf S, et al. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. N Engl J Med 1988; 318: 1162–73\nDrug Information Pharmacists, South West Thames, New Product Assessment. Low-molecular-weight heparins. London: Drug Information Pharmacists Group, 1991\nHommes OW, Bura A, Mazzolai L, et al. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Ann Intern Med 1992; 116: 279–84\nFrydman AM, Bara L, Le Roux Y, et al. The antithrombotic activity and pharmacokinetics of enoxaparin, a low molecular weight heparin, in humans given single subcutaneous doses of 20 to 80 ml. J Clin Pharmacol 1988; 8: 609–18\nCaen lP. A randomized double-blind study between a low molecular weight heparin Kabi 2165 and standard heparin in the prevention of deep vein thrombosis in general surgery. Thromb Haemost 1988; 59: 216–9\nDeehavanne M, Ville D, Berruyer M, et al. Randomized trial of a low molecular weight heparin (Kabi 2165) versus adjusted dose subcutaneous standard heparin in the prophylaxis of deep vein thrombosis after elective hip surgery. Haemostasis 1989; 1: 5–12\nEncke A, Breddin K. Comparison of a low molecular weight and unfractionated heparin for the prevention of deep vein thrombosis in patients undergoing abdominal surgery. Br J Surg 1988; 75: 1058–63\nEriksson BI, Eriksson E, Wudenvik H, et al. Comparison of low molecular weight heparin and unfractionated heparin in prophylaxis of deep vein thrombosis and pulmonary embolism in total hip replacement [abstract]. Thromb Haemostas 1989; 62: 470\nFricker lP, Vergnes Y, Schach R, et al. Low dose heparin versus low molecular weight heparin (Kabi 2165, Fragmin) in the prophlyaxis of thromboembolic complications of abdominal oncological surgery. Eur J Clin Invest 1988; 18: 561–7\nHartl P, Brticke P, Dienstl E, et al. Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragmin. Thromb Res 1990; 57: 577–84\nKakkar VV, Murray W1G. Efficacy and safety oflow molecular weight heparin (CY216) in preventing postoperative thrombo-embolism: a cooperative study. Br J Surg 1985; 72: 786–91\nLeyvraz PF, Postel M, Bachmann F, et al. Prevention of deep vein thrombosis after total hip replacement: randomized comparison between adjusted dose unfractionated heparin and low molecular weight heparin (CY216). In: Hoeck lA, editor. Deep vein thrombosis following total hip replacement. Amsterdam: University of Amsterdam, 1990\nPlanes A, Vochelle N, Mazas F, et al. Prevention of postoperative venous thrombosis: a randomized trial comparing unfractionated heparin with low molecular weight heparin in patients undergoing total hip replacement. Thromb Haemostas 1988; 60: 407–11\nSamama M, Bernard P, Bonnardot JP, et al. Low molecular weight heparin with unfractionated heparin in prevention of postoperative thrombosis. Br J Surg 1988; 75: 128–31\nNurmohamed MT, Rosendaal FR, Büller HR, et al. Low molecular weight heparins versus standard heparins in general and orthopaedic surgery: a meta analysis. Lancet 1992; 340: 152–6\nLeizorovicz A, Haugh MC, Chopuis ER, et al. Low molecular weight heparin in prevention of perioperative thrombosis. BMJ 1992; 305 (6859): 913–20\nDrummond M, Aristides M, Davies L, et al. Economic evaluation of standard heparin and enoxaparin for prophylaxis against deep vein thrombosis in elective hip surgery. Br J Surg 1994; 81 (12): 1742–6\nBorris LC, Lassen MR, Jensen HP, et al. Perioperative thrombosis prophylaxis with low molecular weight heparins in elective hip surgery: clinical and economic considerations. Int J Clin Pharmacol Ther 1994; 32 (5): 262–8\nHeaton D, Pearce M. Low molecular weight versus unfractionated heparin: a clinical and economic appraisal. Pharmacoeconomics 1995; 8 (2): 91–9\nAnderson DR, O’Brien BJ, Levine MN, et al. Efficacy and cost of low molecular weight heparin compared with standard heparin for the prevention of deep vein thrombosis after total hip arthroplasty. Ann Intern Med 1993; 119: 1105–12\nGarattini L, Grilli R, Scopelliti D, et al. A proposal for Italian guidelines in pharmacoeconomics. Pharmacoeconomics 1995; 7 (1): 1–6\nNyman U. Diagnostic strategies in acute pulmonary embolism. Haemostasis 1993; 23 Suppl.1: 220–6\nKakkar Vv. Prevention of fatal pulmonary embolism. Haemostasis 1993; 23 Suppl.1: 42–50\nLaw Om n 80, 7 XI 1991, Gazzetta Ufficiale n 2876, Rome: Italian Government, 1991 Dec 6\nLevine M, Gent M, Hirsch J, et al. A comparison of low-molecular weight heparin administered primarily at home with unfractionated heparin administered in hospital for proximal deep vein thrombosis. N Engl J Med 1996; 334 (11): 677–81\nKoopman MMW, Prandoni P, Piovella F, et al. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. N Engl J Med; 34 (11): 682–7",{"VOID":1941},"10.2165\u002F00019053-199712040-00005","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.2165\u002F00019053-199712040-00005",[1944,1968,1981,1994,2007,2029],{"id":1945,"sortIndex":32,"researcher":28,"roles":1946,"affiliations":1947,"properties":1965,"displayName":1967,"givenName":28,"familyName":28},"ba9ccfc3-11c0-4ca5-b714-f9d8e9e4ad24",[995],[1948,1956],{"id":1949,"sortIndex":32,"affiliation":1950,"properties":28},"93633628-0a4e-4814-925e-fe33c26c0139",{"id":1949,"createTime":28,"updateTime":28,"relativeEntities":1951,"slug":28,"properties":1952,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1955,"statistic":28},[],{"title":1953},{"VI":1954},"National Economic Research Associates (NERA), London, England",[],{"id":1957,"sortIndex":40,"affiliation":1958,"properties":1964},"62127b9f-3e2a-4fef-8f4c-a25395a86913",{"id":1957,"createTime":28,"updateTime":28,"relativeEntities":1959,"slug":28,"properties":1960,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1963,"statistic":28},[],{"title":1961},{"VI":1962},"Glaxo Wellcome, Greenford, England",[],{},{"title":1966},{"VI":1967},"Adam Lloyd",{"id":1969,"sortIndex":40,"researcher":28,"roles":1970,"affiliations":1971,"properties":1978,"displayName":1980,"givenName":28,"familyName":28},"e4a4c856-01d9-4bef-a8f4-8497bca8fbb0",[995],[1972],{"id":1949,"sortIndex":32,"affiliation":1973,"properties":28},{"id":1949,"createTime":28,"updateTime":28,"relativeEntities":1974,"slug":28,"properties":1975,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1977,"statistic":28},[],{"title":1976},{"VI":1954},[],{"title":1979},{"VI":1980},"Judith A. 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Wakerly",{"id":2030,"sortIndex":46,"researcher":28,"roles":2031,"affiliations":2032,"properties":2041,"displayName":2043,"givenName":28,"familyName":28},"73fb19e8-ebf5-40bb-83e9-51bd4b338951",[995],[2033],{"id":2034,"sortIndex":32,"affiliation":2035,"properties":28},"1117bced-0e10-4f2e-b6af-279ecd5321e9",{"id":2034,"createTime":28,"updateTime":28,"relativeEntities":2036,"slug":28,"properties":2037,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2040,"statistic":28},[],{"title":2038},{"VI":2039},"University of London School of Pharmacy, London, England",[],{"title":2042},{"VI":2043},"Nicholas D. 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We characterize the optimal outcome-based reimbursement policy a health authority should follow to encourage the pharmaceutical firm to undertake research and development activities to generate the information needed to effectively stratify patients. Consistent with the literature, we find that for a pharmaceutical firm that does not undertake research and development activities, when the treatment fails, the total price of the drug must be returned to the healthcare system (full penalization). By contrast, if the firm undertakes research and development activities that make the implementation of personalized medicine possible, treatment failure should not be fully penalized. Surprisingly, in some cases, particularly for high-efficacy drugs and small target populations, the optimal policy may not require any penalty for treatment failure. To illustrate the main results of the analysis, we provide a numerical simulation and a graphical analysis.",{"EN":2119},"Personalized Medicine and Pay for Performance: Should Pharmaceutical Firms be Fully Penalized when Treatment Fails?",{"VOID":2121},"Redekop WK, Mladsi D. The faces of personalized medicine: a framework for understanding its meaning and scope. Value Health. 2013;16:54–9.\nAntoñanzas F, Juárez-Castelló C, Rodríguez-Ibeas R. Some economics on personalized and predictive medicine. Eur J Health Econ. 2015;16(9):985–94.\nAnnemans L, Redekop K, Payne K. Current methodological issues in the economic assessment of personalized medicine. Value Health. 2013;16(6 Suppl.):S20–6.\nSairamesh J, Rossbach M. An economic perspective on personalized medicine. Hugo J. 2013;7(1):1–2.\nConnor S. Our Drugs Do Not Work On Most Patients. The Independent (London), 13 Dec 2011. http:\u002F\u002Fwww.rense.com\u002Fgeneral69\u002Fglax.htm. Accessed 6 Feb 2018.\nCulbertson AW, Valentine SJ, Naylor S. Personalized medicine: technological innovation and patient empowerment or exuberant hyperbole? Drug Discov World. 2007;8(3):18–32.\nTrusheim MR, Berndt ER, Douglas FL. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Nat Rev Drug Discov. 2007;6(4):287–93.\nJain S, Shankaran V. The economics of personalized therapy in metastatic colorectal cancer. Curr Colorectal Cancer Rep. 2016;12:123–9.\nLièvre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Côté JF, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006;66(8):3992–5.\nBehl AS, Goddard KA, Flottemesch TJ, Veenstra D, Meenan RT, Lin JS, Maciosek MV. Cost-effectiveness analysis of screening for KRAS and BRAF mutations in metastatic colorectal cancer. J Natl Cancer Inst. 2012;104(23):1785–95.\nThierry AR, Mouliere F, El Messaoudi S, Mollevi C, Lopez-Crapez E, Rolet F, Gillet B, Gongora C, Dechelotte P, Robert B, Del Rio M, Lamy PJ, Bibeau F, Nouaille M, Loriot V, Jarrousse AS, Molina F, Mathonnet M, Pezet D, Ychou M. Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nat Med. 2014;20:430–5.\nCarlson JJ, Garrison LP, Ramsey SD, Veenstra DL. The potential clinical and economic outcomes of pharmacogenomic approaches to EGFR-tyrosine kinase inhibitor therapy in non-small-cell lung cancer. Value Health. 2009;12(1):20–7.\nNICE. Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy. 2015. nice.org.uk\u002Fguidance\u002Fta374. Accessed 9 Jan 2018.\nFaulkner E, Annemans L, Garrison L, Helfand M, Holtorf AP, Hornberger J, Hughes D, Li T, Malone D, Payne K, Siebert U, Towse A, Veenstra D, Watkins J, Personalized Medicine Development and Reimbursement Working Group. Challenges in the development and reimbursement of personalized medicine: payer and manufacturer perspectives and implications for health economics and outcomes research: a report of the ISPOR Personalized Medicine Special Interest Group. Value Health. 2012;15(8):1162–71.\nCarlson JJ, Chen S, Garrison LP. Performance-based risk-sharing arrangements: an updated international review. Pharmacoeconomics. 2017;35:1063–72.\nTowse A, Garrison LP. Can’t get no satisfaction? Will pay for performance health? Pharmacoeconomics. 2010;28(2):93–102.\nde Pouvourville G. Risk-sharing agreements for innovative drugs. Eur J Health Econ. 2006;7:155–7.\nPita-Barros P. The simple economics of risk-sharing agreements between the NHS and the pharmaceutical industry. Health Econ. 2011;20:461–70.\nZaric GS, O’Brien BJ. Analysis of a pharmaceutical risk sharing agreement based on the purchaser’s total budget. Health Econ. 2005;14:793–803.\nZaric GS, Xie B. The impact of two pharmaceutical risk-sharing agreements on pricing, promotion and net health benefits. Value Health. 2009;12(5):838–45.\nAntoñanzas F, Juaréz-Castelló C, Rodríguez-Ibeas R. Should health authorities offer risk-sharing contracts to pharmaceutical firms? A theoretical approach. Health Econ Policy Law. 2011;6:391–403.\nTowse A, Garrison LP. Economic incentives for evidence generation: promoting an efficient path to personalized medicine. Value Health. 2013;16(6 Suppl.):S39–43.\nO’Donnell JC. Personalized medicine and the role of health economics and outcomes research: issues, applications, emerging trends, and future research. Value Health. 2013;16(6 Suppl.):S1–3.\nPita-Barros P, Martínez-Giralt X. Health economics: an industrial organization perspective. London, New York: Routledge, Taylor and Francis Group; 2012.\nTrusheim MR, Burgess B, Hu SX, Long T, Averbuch SD, Flynn AA, et al. Quantifying factors for the success of stratified medicine. Nat Rev Drug Discov. 2011;10(11):817–33.\nSatanove D. The challenging economics of the companion diagnostic industry; a compelling case for patent protection. J Intell Prop Ent Law. 2016;6(1):142–71.\nGraf von der Schulenburg JM. Frank M. Rare is frequent and frequent is costly: rare diseases as a challenge for health care systems. Eur J Health Econ. 2015;16(2):113–8.",{"VOID":2123},"10.1007\u002Fs40273-018-0619-4","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs40273-018-0619-4",[2126,2141,2154],{"id":2127,"sortIndex":32,"researcher":28,"roles":2128,"affiliations":2129,"properties":2138,"displayName":2140,"givenName":28,"familyName":28},"eaa75db6-a61e-4832-ba63-b6b9dcc8523e",[995],[2130],{"id":2131,"sortIndex":32,"affiliation":2132,"properties":28},"3029278a-3caa-4191-8c3c-26ea01f283bb",{"id":2131,"createTime":28,"updateTime":28,"relativeEntities":2133,"slug":28,"properties":2134,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2137,"statistic":28},[],{"title":2135},{"VI":2136},"Department of Economics, University of La Rioja, Logroño, Spain",[],{"title":2139},{"VI":2140},"Fernando Antoñanzas",{"id":2142,"sortIndex":40,"researcher":28,"roles":2143,"affiliations":2144,"properties":2151,"displayName":2153,"givenName":28,"familyName":28},"a36f6a03-87ca-4ec1-ac26-67b2fa985ace",[995],[2145],{"id":2131,"sortIndex":32,"affiliation":2146,"properties":28},{"id":2131,"createTime":28,"updateTime":28,"relativeEntities":2147,"slug":28,"properties":2148,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2150,"statistic":28},[],{"title":2149},{"VI":2136},[],{"title":2152},{"VI":2153},"Roberto Rodríguez-Ibeas",{"id":2155,"sortIndex":123,"researcher":28,"roles":2156,"affiliations":2157,"properties":2164,"displayName":2166,"givenName":28,"familyName":28},"0e79af62-5ef0-41ff-96f6-ff171da4e06d",[995],[2158],{"id":2131,"sortIndex":32,"affiliation":2159,"properties":28},{"id":2131,"createTime":28,"updateTime":28,"relativeEntities":2160,"slug":28,"properties":2161,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2163,"statistic":28},[],{"title":2162},{"VI":2136},[],{"title":2165},{"VI":2166},"Carmelo A. 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The impact of insomnia is often ignored both by the individual and by society in terms of its clinical and socioeconomic ramifications. Insomnia is therefore under-appreciated and almost certainly under-treated, thus making it a serious health concern. It is estimated that more than 60 million Americans suffer from insomnia annually, and this figure is expected to grow to 100 million by the middle of the 21st century. Whether it be difficulty initiating or maintaining sleep, the disruption of nocturnal sleep will invariably impact on daytime activities and often results in daytime fatigue, performance deficits (including memory and other cognitive deficits), an increase in the number of sick days taken by an individual and accidents (some catastrophic). This review examines the costs directly related to insomnia in various sectors of healthcare, the indirect costs associated with accidents, sick days and decreased work productivity, and related costs resulting from insomnia but which meet neither the criteria of direct nor indirect cost categories. The total direct, indirect and related costs of insomnia are conservatively estimated at $US30 to 35 billion annually in the US (1994 dollars). Economic gains can be made by treating patients on an outpatient basis in sleep centres.",{"EN":2243},"The Socioeconomic Impact of Insomnia",{"VOID":2245},"Wake up America: A national sleep alert. Vol. 2. Working group reports. Report of the national commission on sleep disorders research. Washington DC: National Institutes of Health, US Government Printing Office, 1994\nMellinger GD, Balter MB, Uhlenhuth EH, et al. Insomnia and its treatment. Prevalence and correlates. Arch Gen Psychiatry 1985; 42: 225–32\nKaracan I, Thornby JI, Anch M, et al. 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Eur Arch Psychiatry Neurol Sci 1989; 239: 113–24\nLavie P. Sleep habits and sleep disturbances in industrial workers in Israel: main findings and some characteristics of workers complaining of excessive daytime sleepiness. Sleep 1981; 4(2): 147–58\nKales JD, Kales A, Bixler EO, et al. Biopsychobehavioral correlates of insomnia, V: Clinical characteristics and behavioral correlates. Am J Psychiatry 1984; 141(11): 1371–6\nTan TL, Kales JD, Kales A, et al. Biopsychobehavioral correlates of insomnia, IV: diagnosis based on DSM-III. Am J Psychiatry 1984; 141: 357–62\nMason P, Wilkinson G. The prevalence of psychiatric morbidity. Br J Psychiatry 1996; 168: 1–3\nBalter MB, Uhlenhuth EH. New epidemiologic findings about insomnia and its treatment. J Clin Psychiatry 1992; 53(12): 34–9\nAllain H, Delahaye C, Le Cox F, et al. Postmarketing surveillance of zopiclone in insomnia: analysis of 20,513 cases. Sleep 1991; 14(5): 408–13\nBalter MB, Uhlenhuth EH. The beneficial and adverse effects of hypnotics. J Clin Psychiatry 1991; 52(7): 16–23\nHumphreys S, Hallström C. Benzodiazepine dependence and withdrawal — an update. Prim Care Psychiatry 1995; 1: 99–105\nDement WC. The proper use of sleeping pills in the primary care setting. J Clin Psychiatry 1992; 53(12): 50–6\nColeman RM, Zarcone VP, Redington DJ, et al. Sleep-wake disorders in a family practice clinic. Sleep Res 1980; 9: 192\nBerlin RM, Litovitz GL, Diaz MA, et al. Sleep disorders on a psychiatric consultation service. Am J Psychiatry 1984; 141(4): 582–4\nMindell JA, Moline ML, Zendell SM, et al. Pediatricians and sleep disorders: training and practice. Pediatrics 1994; 94(2): 194–200\nOrr WC, Stahl ML, Dement WC. Physician education in sleep disorders. J Med Educ 1980; 55: 367–9\nMerkel WT, Walbroehl GS. The annual third-year resident rampage: a separation crisis of manageable proportions. J Med Educ 1980; 55: 366–7\nChung SA, Hussain MRG, Shapiro CM. How much do primary care physicians in Ontario know about sleep apnea? Sleep Res 1996. In press\nKroenke K, Mangelsdorff AD. Common symptoms in ambulatory care: incidence, evaluation, therapy, and outcome. Am J Med 1989; 86: 262–6\nKupych-Woloshyn N, MacFarlane J, Shapiro CM. A group approach for the management of insomnia. J Psychosom Res 1993; 37 Suppl. 1: 39–44\nO’Reilly R. The use of sedative-hypnotic drugs in a university teaching hospital. Can Med Assoc J 1990; 142(6): 585–9\nSanford JR. Tolerance of debility in elderly dependents by supporters at home: its significance for hospital practice. BMJ 1975; 3: 471–3\nPollack CP, Perlick D. Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol 1991; 4: 204–10\nWalsh JK, Engelhardt CL, Hartman PG. The direct economic cost of insomnia. In: Nutt D, Mendelson W, editors. Hypnotics and anxiolytics. London: Baillière Tindall, 1995; 369–81\nMendelson WB, Garnett D, Linnoila M. Do insomniacs have impaired daytime functioning? Biol Psychiatry 1984; 19(8): 1261–4\nMitler MM, Carskadon MA, Czeisler CA, et al. Catastrophes, sleep, and public policy: consensus report. Sleep 1988; 11(1): 100–9\nStoller MK. Economic effects of insomnia. Clin Ther 1994; 16(5): 873–97\nLauber JK, Kayten PJ. Sleepiness, circadian dysrhythmia, and fatigue in transportation system accidents. Sleep 1988; 11(6): 503–12\nO’Hanlon JF. Ten ways for physicians to minimize the risk of patients causing traffic accidents while under the influence of prescribed psychoactive medication. Prim Care Psychiatry 1995; 1: 77–85\nJennum P, Sjol A. Self-assessed cognitive function in snorers and sleep apneics. Eur Neurol 1994; 34: 204–8\nGreenberg PE, Stiglin LE, Findelstein SN, et al. The economic burden of depression. J Clin Psych 1993; 54: 405–18\nWalsh JK. Correlates, Consequences and Costs Associated with Insomnia. The Pharmacological Management of Insomnia: A White Paper of the National Sleep Foundation. In press\nLavis JN, Anderson GM. Appropriateness in health care delivery: definitions, measurement and policy implications. Can Med Assoc J 1996; 154(3): 321–8",{"VOID":2247},"10.2165\u002F00019053-199600101-00003","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.2165\u002F00019053-199600101-00003",[2250,2265],{"id":2251,"sortIndex":32,"researcher":28,"roles":2252,"affiliations":2253,"properties":2262,"displayName":2264,"givenName":28,"familyName":28},"f4c51b6f-b3c5-4847-9a5a-83d79df5591c",[995],[2254],{"id":2255,"sortIndex":32,"affiliation":2256,"properties":28},"20df6372-8cf6-42ce-ba29-42b4297f9c2c",{"id":2255,"createTime":28,"updateTime":28,"relativeEntities":2257,"slug":28,"properties":2258,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2261,"statistic":28},[],{"title":2259},{"VI":2260},"Department of Psychiatry, The University of Toronto and the Toronto Hospital (Western Division), Toronto, Canada",[],{"title":2263},{"VI":2264},"Lisa A. 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