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Reports are emerging of a new severe hyperinflammatory syndrome related to coronavirus disease 2019 in children and adolescents. The Centers for Disease Control and Prevention has designated this disease multisystem inflammatory syndrome in children. Our objective was to develop a clinical inpatient protocol for the evaluation, management, and follow-up of patients with this syndrome.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Data Sources:\u003C\u002Fjats:title>\n            \u003Cjats:p>The protocol was developed by a multidisciplinary team based on relevant literature related to coronavirus disease 2019, multisystem inflammatory syndrome in children, and related inflammatory syndromes, as well as our experience caring for children with multisystem inflammatory syndrome in children. Data were obtained on patients with multisystem inflammatory syndrome in children at our institution from the pre-protocol and post-protocol periods.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Data Synthesis:\u003C\u002Fjats:title>\n            \u003Cjats:p>Our protocol was developed in order to identify cases of multisystem inflammatory syndrome in children with high sensitivity, stratify risk to guide treatment, recognize co-infectious or co-inflammatory processes, mitigate coronary artery abnormalities, and manage hyperinflammatory shock. Key elements of evaluation include case identification using broad clinical characteristics and comprehensive laboratory and imaging investigations. Treatment centers around glucocorticoids and IV immunoglobulin with biologic immunomodulators as adjuncts. Multidisciplinary follow-up after discharge is indicated to manage continued outpatient therapy and evaluate for disease sequelae. In nearly 2 months, we admitted 54 patients with multisystem inflammatory syndrome in children, all of whom survived without the need for invasive ventilatory or mechanical circulatory support. After institution of this protocol, patients received earlier treatment and had shorter lengths of hospital stay.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\n            \u003Cjats:p>This report provides guidance to clinicians on evaluation, management, and follow-up of patients with a novel hyperinflammatory syndrome related to coronavirus disease 2019 known as multisystem inflammatory syndrome in children. It is based on the relevant literature and our experience. Instituting such a protocol during a global pandemic is feasible and is associated with patients receiving treatment and returning home more quickly.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":168},"Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children’s Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up",{"VOID":170},"33003176",{"VOID":172},"10.1097\u002Fpcc.0000000000002598","PUBLICATION","VERIFIED","2024-09-20T23:33:38.635+00:00","Auto Verify",[178],"EN","https:\u002F\u002Fjournals.lww.com\u002F10.1097\u002FPCC.0000000000002598",[181,201,217,245,267,288,310,326,344,361,383,401,433,455,472,489,504,522,539,561,576],{"id":182,"sortIndex":183,"researcher":24,"roles":184,"affiliations":185,"properties":196},"d9809af8-71e3-4abd-a02a-b19be39f92d8",12,[],[186],{"id":187,"sortIndex":25,"affiliation":188,"properties":24},"826aef9a-da41-4574-9cbc-d69e403059bf",{"id":189,"createTime":190,"updateTime":190,"relativeEntities":191,"slug":192,"properties":193,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"83cd07d2-d467-4600-aaa1-b4e3dbf22b49","2024-09-20T23:33:38.858+00:00",[],"Department-of-Pharmacy-New-York-Presbyterian-Morgan-Stanley-Children-s-Hospital-of-New-York-New-York-NY-",{"title":194},{"EN":195},"Department of Pharmacy, New York-Presbyterian Morgan Stanley Children's Hospital of New York, New York, NY.",{"openalex":197,"title":199},{"VOID":198},"A5034668879",{"EN":200},"Jennifer Cheng",{"id":202,"sortIndex":203,"researcher":24,"roles":204,"affiliations":205,"properties":212},"3ec41985-3653-4e4a-bbbe-bb3eab129ba7",10,[],[206],{"id":207,"sortIndex":25,"affiliation":208,"properties":24},"8baa4e6b-40a2-49e2-887b-349dbd34a4b6",{"id":189,"createTime":190,"updateTime":190,"relativeEntities":209,"slug":192,"properties":210,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":211},{"EN":195},{"openalex":213,"title":215},{"VOID":214},"A5007568784",{"EN":216},"Leanne Svoboda",{"id":218,"sortIndex":219,"researcher":24,"roles":220,"affiliations":221,"properties":238},"08247954-dd0d-4aca-a26c-4752096a367d",8,[],[222,232],{"id":223,"sortIndex":73,"affiliation":224,"properties":24},"0abbe600-b510-4e6e-a992-be07c191ee74",{"id":225,"createTime":226,"updateTime":226,"relativeEntities":227,"slug":228,"properties":229,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"cc334c24-0664-4fb3-b7b5-e6edae10a7b9","2024-09-20T23:33:38.825+00:00",[],"Department-of-Dermatology-Division-of-Pediatric-Dermatology-Columbia-University-Irving-Medical-Center-New-York-Presbyterian-Morgan-Stanley-Children-s-Hospital-of-New-York-New-York-NY-",{"title":230},{"EN":231},"Department of Dermatology, Division of Pediatric Dermatology, Columbia University Irving Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital of New York, New York, NY.",{"id":233,"sortIndex":25,"affiliation":234,"properties":24},"47866022-3a31-4100-9a7f-008c7f08d6ff",{"id":225,"createTime":226,"updateTime":226,"relativeEntities":235,"slug":228,"properties":236,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":237},{"EN":231},{"openalex":239,"orcid":241,"title":243},{"VOID":240},"A5076385540",{"VOID":242},"https:\u002F\u002Forcid.org\u002F0000-0003-0646-8192",{"EN":244},"Kimberly D. 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10.1001\u002Fjamainternmed.2020.0994",{"doi":706},"10.1001\u002Fjamainternmed.2020.0994",{"id":24,"text":708,"url":24,"identifiers":709},"Gamez-Gonzalez, 2018, Kawasaki disease shock syndrome: Unique and severe subtype of Kawasaki disease., Pediatr Int, 60, 781, 10.1111\u002Fped.13614",{"doi":710},"10.1111\u002Fped.13614",{"id":24,"text":712,"url":24,"identifiers":713},"Kobayashi, 2012, Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): A randomised, open-label, blinded-endpoints trial., Lancet, 379, 1613, 10.1016\u002FS0140-6736(11)61930-2",{"doi":714},"10.1016\u002FS0140-6736(11)61930-2",{"id":24,"text":716,"url":24,"identifiers":717},"Ogata, 2012, Corticosteroid pulse combination therapy for refractory Kawasaki disease: A randomized trial., Pediatrics, 129, e17, 10.1542\u002Fpeds.2011-0148",{"doi":718},"10.1542\u002Fpeds.2011-0148",{"id":24,"text":720,"url":24,"identifiers":721},"Wardle, 2017, Corticosteroids for the treatment of Kawasaki disease in children., Cochrane Database Syst Rev, 1, CD011188",{},{"id":24,"text":723,"url":24,"identifiers":724},"Chen, 2013, Corticosteroids for viral myocarditis., Cochrane Database Syst Rev, 10, CD004471",{},{"id":24,"text":726,"url":24,"identifiers":727},"Xu, 2020, Effective treatment of severe COVID-19 patients with tocilizumab., Proc Natl Acad Sci U S A, 117, 10970, 10.1073\u002Fpnas.2005615117",{"doi":728},"10.1073\u002Fpnas.2005615117",{"id":24,"text":730,"url":24,"identifiers":731},"Dallaire, 2017, Aspirin dose and prevention of coronary abnormalities in Kawasaki disease., Pediatrics, 139, e20170098, 10.1542\u002Fpeds.2017-0098",{"doi":732},"10.1542\u002Fpeds.2017-0098",false,{"id":735,"createTime":736,"updateTime":736,"relativeEntities":737,"slug":738,"properties":739,"entityType":173,"verifyStatus":174,"verifyTime":736,"verifyNote":176,"syncStatus":23,"languages":753,"translateLanguages":24,"viewCount":25,"primaryUrl":754,"fullTextUrl":24,"authors":755,"publicationType":594,"publisherRelationship":1070,"citationCount":1102,"citationInfo":1103,"publishDate":1106,"publishYear":1107,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1108,"isForceReanalyzing":733},"f1f85140-0b31-4c5b-8f1c-0e12fff6cc2f","2024-10-03T22:24:47.985+00:00",[],"Guidelines-for-the-Management-of-Pediatric-Severe-Traumatic-Brain-Injury-Third-Edition-Update-of-the-Brain-Trauma-Foundation-Guidelines-Executive-Summary",{"mag":740,"keywords":742,"openalex":743,"abstract":745,"title":747,"pm":749,"doi":751},{"VOID":741},"2919334957",{},{"VOID":744},"W2919334957",{"EN":746},"\u003Cjats:sec>\n            \u003Cjats:title>Objectives:\u003C\u002Fjats:title>\n            \u003Cjats:p>The purpose of this work is to identify and synthesize research produced since the second edition of these Guidelines was published and incorporate new results into revised evidence-based recommendations for the treatment of severe traumatic brain injury in pediatric patients.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods and Main Results:\u003C\u002Fjats:title>\n            \u003Cjats:p>This document provides an overview of our process, lists the new research added, and includes the revised recommendations. Recommendations are only provided when there is supporting evidence. This update includes 22 recommendations, nine are new or revised from previous editions. New recommendations on neuroimaging, hyperosmolar therapy, analgesics and sedatives, seizure prophylaxis, temperature control\u002Fhypothermia, and nutrition are provided. None are level I, three are level II, and 19 are level III. The Clinical Investigators responsible for these Guidelines also created a companion algorithm that supplements the recommendations with expert consensus where evidence is not available and organizes possible interventions into first and second tier utilization. The purpose of publishing the algorithm as a separate document is to provide guidance for clinicians while maintaining a clear distinction between what is evidence based and what is consensus based. This approach allows, and is intended to encourage, continued creativity in treatment and research where evidence is lacking. Additionally, it allows for the use of the evidence-based recommendations as the foundation for other pathways, protocols, or algorithms specific to different organizations or environments. The complete guideline document and supplemental appendices are available electronically from this journal. These documents contain summaries and evaluations of all the studies considered, including those from prior editions, and more detailed information on our methodology.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\n            \u003Cjats:p>New level II and level III evidence-based recommendations and an algorithm provide additional guidance for the development of local protocols to treat pediatric patients with severe traumatic brain injury. Our intention is to identify and institute a sustainable process to update these Guidelines as new evidence becomes available.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":748},"Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary",{"VOID":750},"30830016",{"VOID":752},"10.1097\u002Fpcc.0000000000001736",[178],"https:\u002F\u002Fjournals.lww.com\u002F00130478-201903000-00009",[756,778,799,820,841,862,883,904,925,946,967,988,1009,1028,1049],{"id":757,"sortIndex":203,"researcher":24,"roles":758,"affiliations":759,"properties":771},"dcc0df27-5e29-4177-afe2-f37ec9b746c7",[],[760],{"id":761,"sortIndex":25,"affiliation":762,"properties":24},"dbd41236-1d9c-480d-9131-da6175062e56",{"id":763,"createTime":764,"updateTime":765,"relativeEntities":766,"slug":767,"properties":768,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"61b1db2d-d5c0-4241-9d0e-a872af07f261","2024-02-06T04:04:36.088+00:00","2024-10-03T22:24:48.179+00:00",[],"Department-of-Neurosurgery-Stanford-University-Stanford-CA",{"title":769},{"VI":770},"Department of Neurosurgery, Stanford University, Stanford, CA",{"openalex":772,"orcid":774,"title":776},{"VOID":773},"A5012203120",{"VOID":775},"https:\u002F\u002Forcid.org\u002F0000-0002-2651-4603",{"EN":777},"Gerald A. 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Grenvik Professor of Critical Care Medicine, Vice Chair, Department of Critical Care Medicine, Professor of Anesthesiology, Pediatrics, Bioengineering, and Clinical and Translational Science, Director, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA.",{"openalex":1043,"orcid":1045,"title":1047},{"VOID":1044},"A5080778824",{"VOID":1046},"https:\u002F\u002Forcid.org\u002F0000-0002-2627-913X",{"EN":1048},"Patrick M. Kochanek",{"id":1050,"sortIndex":183,"researcher":24,"roles":1051,"affiliations":1052,"properties":1063},"e5263776-46ee-425d-995b-80a5beb39781",[],[1053],{"id":1054,"sortIndex":25,"affiliation":1055,"properties":24},"8cae4424-575e-4f21-abe6-743dea3ce29d",{"id":1056,"createTime":1057,"updateTime":1057,"relativeEntities":1058,"slug":1059,"properties":1060,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"39b18c8c-a051-4ffa-bd03-0d7e5bd28a9d","2024-10-03T22:24:48.129+00:00",[],"School-of-Nursing-School-of-Medicine-Department-of-Pediatrics-Division-of-Pediatric-Critical-Care-Medicine-Duke-University-Durham-NC-",{"title":1061},{"EN":1062},"School of Nursing\u002FSchool of Medicine, Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke University, Durham, NC.",{"openalex":1064,"orcid":1066,"title":1068},{"VOID":1065},"A5017915765",{"VOID":1067},"https:\u002F\u002Forcid.org\u002F0000-0003-1501-8994",{"EN":1069},"Karin Reuter‐Rice",{"url":24,"publisher":1071,"properties":1096},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1072,"slug":10,"properties":1073,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1079,"manageAffiliations":1080,"indexDatabases":1081,"url":147,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1074,"issn":1075,"introduce":1076,"eissn":1077,"title":1078},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1082,1089],{"id":108,"indexDatabase":1083,"url":123,"indexYears":24,"academicFieldIds":1088,"indexDatabaseRanking":24},{"id":110,"createTime":111,"updateTime":112,"relativeEntities":1084,"label":1085,"description":1086,"key":119,"publicationTags":1087,"standard":24},[],{"EN":115,"VI":115},{"VI":117,"EN":118},[121,122],[125,126],{"id":128,"indexDatabase":1090,"url":141,"indexYears":142,"academicFieldIds":1095,"indexDatabaseRanking":146},{"id":130,"createTime":131,"updateTime":132,"relativeEntities":1091,"label":1092,"description":1093,"key":138,"publicationTags":1094,"standard":24},[],{"EN":135,"VI":135},{"EN":135,"VI":137},[140],[144,145],{"volume":1097,"pages":1099,"issue":1101},{"VOID":1098},"20",{"VOID":1100},"280-289",{"VOID":627},100,{"total":1102,"publishYear":24,"statisticByYear":1104},{"2019":247,"2020":1105,"2021":578,"2022":578,"2023":385,"2024":65},32,"2019-03-01",2019,[1109,1112,1115,1119,1123,1127,1131,1135,1139,1143,1147,1151,1155,1159,1163,1167,1171,1175,1179,1183,1187,1191,1195,1199,1203,1207,1211,1215,1219,1223,1227,1231,1235,1239,1243,1247,1251,1255,1258,1262,1266,1270,1273,1277,1280,1284,1288,1292,1295,1299,1303,1307,1310,1314,1318,1322,1325,1329,1333,1337,1341,1345,1349],{"id":24,"text":1110,"url":24,"identifiers":1111},"Kochanek, Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines. Pediatr Crit Care Med 2019; 20 (Suppl 1):S1–S82",{},{"id":24,"text":1113,"url":24,"identifiers":1114},"Kochanek, 2012, Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents—second edition.[Erratum appears in Pediatr Crit Care Med. 2012 Mar;13(2):252]., Pediatr Crit Care Med, 13, S1",{},{"id":24,"text":1116,"url":24,"identifiers":1117},"Carney, 2017, Guidelines for the management of severe traumatic brain injury, fourth edition., Neurosurgery, 80, 6, 10.1227\u002FNEU.0000000000001432",{"doi":1118},"10.1227\u002FNEU.0000000000001432",{"id":24,"text":1120,"url":24,"identifiers":1121},"Kochanek, 2019, Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies., Pediatr Crit Care Med, 20, 269, 10.1097\u002FPCC.0000000000001737",{"doi":1122},"10.1097\u002FPCC.0000000000001737",{"id":24,"text":1124,"url":24,"identifiers":1125},"Bell, 2013, Differences in medical therapy goals for children with severe traumatic brain injury-an international study., Pediatr Crit Care Med, 14, 811, 10.1097\u002FPCC.0b013e3182975e2f",{"doi":1126},"10.1097\u002FPCC.0b013e3182975e2f",{"id":24,"text":1128,"url":24,"identifiers":1129},"Bell, 2017, Challenges and opportunities for pediatric severe TBI-review of the evidence and exploring a way forward., Childs Nerv Syst, 33, 1663, 10.1007\u002Fs00381-017-3530-y",{"doi":1130},"10.1007\u002Fs00381-017-3530-y",{"id":24,"text":1132,"url":24,"identifiers":1133},"Kurz, 2016, Variation in anticonvulsant selection and electroencephalographic monitoring following severe traumatic brain injury in children-understanding resource availability in sites participating in a comparative effectiveness study., Pediatr Crit Care Med, 17, 649, 10.1097\u002FPCC.0000000000000765",{"doi":1134},"10.1097\u002FPCC.0000000000000765",{"id":24,"text":1136,"url":24,"identifiers":1137},"Jha, 2017, Adding insight to injury: A new era in neurotrauma., Lancet Neurol, 16, 578, 10.1016\u002FS1474-4422(17)30225-9",{"doi":1138},"10.1016\u002FS1474-4422(17)30225-9",{"id":24,"text":1140,"url":24,"identifiers":1141},"Kochanek, 2015, Tackling the challenges of clinical trials for severe traumatic brain injury in children: Screening, phenotyping, and adapting., Crit Care Med, 43, 1544, 10.1097\u002FCCM.0000000000001041",{"doi":1142},"10.1097\u002FCCM.0000000000001041",{"id":24,"text":1144,"url":24,"identifiers":1145},"Bennett, 2017, Functional outcome after intracranial pressure monitoring for children with severe traumatic brain injury., JAMA Pediatr, 171, 965, 10.1001\u002Fjamapediatrics.2017.2127",{"doi":1146},"10.1001\u002Fjamapediatrics.2017.2127",{"id":24,"text":1148,"url":24,"identifiers":1149},"Alkhoury, 2014, Intracranial pressure monitoring in children with severe traumatic brain injury: National trauma data bank-based review of outcomes., JAMA Surg, 149, 544, 10.1001\u002Fjamasurg.2013.4329",{"doi":1150},"10.1001\u002Fjamasurg.2013.4329",{"id":24,"text":1152,"url":24,"identifiers":1153},"Bennett, 2012, Variation in intracranial pressure monitoring and outcomes in pediatric traumatic brain injury., Arch Pediatr Adolesc Med, 166, 641, 10.1001\u002Farchpediatrics.2012.322",{"doi":1154},"10.1001\u002Farchpediatrics.2012.322",{"id":24,"text":1156,"url":24,"identifiers":1157},"Stippler, 2012, Brain tissue oxygen monitoring after severe traumatic brain injury in children: Relationship to outcome and association with other clinical parameters., J Neurosurg Pediatr, 10, 383, 10.3171\u002F2012.8.PEDS12165",{"doi":1158},"10.3171\u002F2012.8.PEDS12165",{"id":24,"text":1160,"url":24,"identifiers":1161},"Figaji, 2010, The effect of increased inspired fraction of oxygen on brain tissue oxygen tension in children with severe traumatic brain injury., Neurocrit Care, 12, 430, 10.1007\u002Fs12028-010-9344-3",{"doi":1162},"10.1007\u002Fs12028-010-9344-3",{"id":24,"text":1164,"url":24,"identifiers":1165},"Bailey, 2012, Monitoring and prediction of intracranial hypertension in pediatric traumatic brain injury: Clinical factors and initial head computed tomography., J Trauma Acute Care Surg, 72, 263, 10.1097\u002FTA.0b013e31822a9512",{"doi":1166},"10.1097\u002FTA.0b013e31822a9512",{"id":24,"text":1168,"url":24,"identifiers":1169},"Bata, 2014, Role of routine repeat head imaging in paediatric traumatic brain injury., ANZ J Surg, 84, 438, 10.1111\u002Fans.12582",{"doi":1170},"10.1111\u002Fans.12582",{"id":24,"text":1172,"url":24,"identifiers":1173},"Miller Ferguson, 2016, Intracranial hypertension and cerebral hypoperfusion in children with severe traumatic brain injury: Thresholds and burden in accidental and abusive insults., Pediatr Crit Care Med, 17, 444, 10.1097\u002FPCC.0000000000000709",{"doi":1174},"10.1097\u002FPCC.0000000000000709",{"id":24,"text":1176,"url":24,"identifiers":1177},"Mehta, 2010, Relationship of intracranial pressure and cerebral perfusion pressure with outcome in young children after severe traumatic brain injury., Dev Neurosci, 32, 413, 10.1159\u002F000316804",{"doi":1178},"10.1159\u002F000316804",{"id":24,"text":1180,"url":24,"identifiers":1181},"Allen, 2014, Age-specific cerebral perfusion pressure thresholds and survival in children and adolescents with severe traumatic brain injury*., Pediatr Crit Care Med, 15, 62, 10.1097\u002FPCC.0b013e3182a556ea",{"doi":1182},"10.1097\u002FPCC.0b013e3182a556ea",{"id":24,"text":1184,"url":24,"identifiers":1185},"Vavilala, 2014, Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury., Crit Care Med, 42, 2258, 10.1097\u002FCCM.0000000000000507",{"doi":1186},"10.1097\u002FCCM.0000000000000507",{"id":24,"text":1188,"url":24,"identifiers":1189},"Shein, 2016, Effectiveness of pharmacological therapies for intracranial hypertension in children with severe traumatic brain injury–results from an automated data collection system time-synched to drug administration., Pediatr Crit Care Med, 17, 236, 10.1097\u002FPCC.0000000000000610",{"doi":1190},"10.1097\u002FPCC.0000000000000610",{"id":24,"text":1192,"url":24,"identifiers":1193},"Piper, 2015, Hypertonic saline in paediatric traumatic brain injury: A review of nine years’ experience with 23.4% hypertonic saline as standard hyperosmolar therapy., Anaesth Intensive Care, 43, 204, 10.1177\u002F0310057X1504300210",{"doi":1194},"10.1177\u002F0310057X1504300210",{"id":24,"text":1196,"url":24,"identifiers":1197},"Webster, 2015, Higher-volume hypertonic saline and increased thrombotic risk in pediatric traumatic brain injury., J Crit Care, 30, 1267, 10.1016\u002Fj.jcrc.2015.07.022",{"doi":1198},"10.1016\u002Fj.jcrc.2015.07.022",{"id":24,"text":1200,"url":24,"identifiers":1201},"Gonda, 2013, Complications associated with prolonged hypertonic saline therapy in children with elevated intracranial pressure., Pediatr Crit Care Med, 14, 610, 10.1097\u002FPCC.0b013e318291772b",{"doi":1202},"10.1097\u002FPCC.0b013e318291772b",{"id":24,"text":1204,"url":24,"identifiers":1205},"Welch, 2016, Fentanyl and midazolam are ineffective in reducing episodic intracranial hypertension in severe pediatric traumatic brain injury., Crit Care Med, 44, 809, 10.1097\u002FCCM.0000000000001558",{"doi":1206},"10.1097\u002FCCM.0000000000001558",{"id":24,"text":1208,"url":24,"identifiers":1209},"Andrade, 2011, Continuous ventricular cerebrospinal fluid drainage with intracranial pressure monitoring for management of posttraumatic diffuse brain swelling., Arq Neuropsiquiatr, 69, 79, 10.1590\u002FS0004-282X2011000100016",{"doi":1210},"10.1590\u002FS0004-282X2011000100016",{"id":24,"text":1212,"url":24,"identifiers":1213},"Liesemer, 2011, Early post-traumatic seizures in moderate to severe pediatric traumatic brain injury: Rates, risk factors, and clinical features., J Neurotrauma, 28, 755, 10.1089\u002Fneu.2010.1518",{"doi":1214},"10.1089\u002Fneu.2010.1518",{"id":24,"text":1216,"url":24,"identifiers":1217},"Tasker, 2017, Updating evidence for using hypothermia in pediatric severe traumatic brain injury: Conventional and bayesian meta-analytic perspectives., Pediatr Crit Care Med, 18, 355, 10.1097\u002FPCC.0000000000001098",{"doi":1218},"10.1097\u002FPCC.0000000000001098",{"id":24,"text":1220,"url":24,"identifiers":1221},"Crompton, 2017, Meta-analysis of therapeutic hypothermia for traumatic brain injury in adult and pediatric patients., Crit Care Med, 45, 575, 10.1097\u002FCCM.0000000000002205",{"doi":1222},"10.1097\u002FCCM.0000000000002205",{"id":24,"text":1224,"url":24,"identifiers":1225},"Tasker, 2017, Updating evidence for using therapeutic hypothermia in pediatric severe traumatic brain injury., Crit Care Med, 45, e1091, 10.1097\u002FCCM.0000000000002526",{"doi":1226},"10.1097\u002FCCM.0000000000002526",{"id":24,"text":1228,"url":24,"identifiers":1229},"Crompton, 2017, The authors reply., Crit Care Med, 45, e1091, 10.1097\u002FCCM.0000000000002565",{"doi":1230},"10.1097\u002FCCM.0000000000002565",{"id":24,"text":1232,"url":24,"identifiers":1233},"Adelson, 2013, Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): A phase 3, randomised controlled trial., Lancet Neurol, 12, 546, 10.1016\u002FS1474-4422(13)70077-2",{"doi":1234},"10.1016\u002FS1474-4422(13)70077-2",{"id":24,"text":1236,"url":24,"identifiers":1237},"Beca, 2015, Hypothermia for traumatic brain injury in children-a phase ii randomized controlled trial., Crit Care Med, 43, 1458, 10.1097\u002FCCM.0000000000000947",{"doi":1238},"10.1097\u002FCCM.0000000000000947",{"id":24,"text":1240,"url":24,"identifiers":1241},"Hutchison, 2010, Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: A post hoc analysis of the Hypothermia Pediatric Head Injury Trial., Dev Neurosci, 32, 406, 10.1159\u002F000323260",{"doi":1242},"10.1159\u002F000323260",{"id":24,"text":1244,"url":24,"identifiers":1245},"Empey, 2013, Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury., Crit Care Med, 41, 2379, 10.1097\u002FCCM.0b013e318292316c",{"doi":1246},"10.1097\u002FCCM.0b013e318292316c",{"id":24,"text":1248,"url":24,"identifiers":1249},"Mellion, 2013, High-dose barbiturates for refractory intracranial hypertension in children with severe traumatic brain injury., Pediatr Crit Care Med, 14, 239, 10.1097\u002FPCC.0b013e318271c3b2",{"doi":1250},"10.1097\u002FPCC.0b013e318271c3b2",{"id":24,"text":1252,"url":24,"identifiers":1253},"Pechmann, 2015, Decompressive craniectomy after severe traumatic brain injury in children: Complications and outcome., Neuropediatrics, 46, 5, 10.1055\u002Fs-0034-1393707",{"doi":1254},"10.1055\u002Fs-0034-1393707",{"id":24,"text":1256,"url":24,"identifiers":1257},"Prasad, 2015, Surgical results of decompressive craniectomy in very young children: A level one trauma centre experience from India., Brain Inj, 1",{},{"id":24,"text":1259,"url":24,"identifiers":1260},"Desgranges, 2014, Intraoperative blood loss during decompressive craniectomy for intractable intracranial hypertension after severe traumatic brain injury in children., Childs Nerv Syst, 30, 1393, 10.1007\u002Fs00381-014-2417-4",{"doi":1261},"10.1007\u002Fs00381-014-2417-4",{"id":24,"text":1263,"url":24,"identifiers":1264},"Khan, 2014, Predictors of poor outcome of decompressive craniectomy in pediatric patients with severe traumatic brain injury: A retrospective single center study from Pakistan., Childs Nerv Syst, 30, 277, 10.1007\u002Fs00381-013-2225-2",{"doi":1265},"10.1007\u002Fs00381-013-2225-2",{"id":24,"text":1267,"url":24,"identifiers":1268},"Csókay, 2012, The importance of very early decompressive craniectomy as a prevention to avoid the sudden increase of intracranial pressure in children with severe traumatic brain swelling (retrospective case series)., Childs Nerv Syst, 28, 441, 10.1007\u002Fs00381-011-1661-0",{"doi":1269},"10.1007\u002Fs00381-011-1661-0",{"id":24,"text":1271,"url":24,"identifiers":1272},"Suarez, 2011, Decompressive craniectomy in 14 children with severe head injury: Clinical results with long-term follow-up and review of the literature., J Trauma, 71, 133",{},{"id":24,"text":1274,"url":24,"identifiers":1275},"Adamo, 2009, Decompressive craniectomy and postoperative complication management in infants and toddlers with severe traumatic brain injuries., J Neurosurg Pediatr, 3, 334, 10.3171\u002F2008.12.PEDS08310",{"doi":1276},"10.3171\u002F2008.12.PEDS08310",{"id":24,"text":1278,"url":24,"identifiers":1279},"Figaji, 2006, Surgical treatment for “brain compartment syndrome” in children with severe head injury., S Afr Med J, 96, 969",{},{"id":24,"text":1281,"url":24,"identifiers":1282},"Messing-Jünger, 2003, Decompressive craniectomy in severe brain injury., Zentralbl Neurochir, 64, 171, 10.1055\u002Fs-2003-44616",{"doi":1283},"10.1055\u002Fs-2003-44616",{"id":24,"text":1285,"url":24,"identifiers":1286},"Taha, 2011, Effect of early nutritional support on intensive care unit length of stay and neurological status at discharge in children with severe traumatic brain injury., J Neurosci Nurs, 43, 291, 10.1097\u002FJNN.0b013e318234e9b2",{"doi":1287},"10.1097\u002FJNN.0b013e318234e9b2",{"id":24,"text":1289,"url":24,"identifiers":1290},"Bar-Joseph, 2009, Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension., J Neurosurg Pediatr, 4, 40, 10.3171\u002F2009.1.PEDS08319",{"doi":1291},"10.3171\u002F2009.1.PEDS08319",{"id":24,"text":1293,"url":24,"identifiers":1294},"Bourdages, 2010, Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy., Pediatr Crit Care Med, 11, 408",{},{"id":24,"text":1296,"url":24,"identifiers":1297},"Chin, 2015, Effect of administration of neuromuscular blocking agents in children with severe traumatic brain injury on acute complication rates and outcomes: A secondary analysis from a randomized, controlled trial of therapeutic hypothermia., Pediatr Crit Care Med, 16, 352, 10.1097\u002FPCC.0000000000000344",{"doi":1298},"10.1097\u002FPCC.0000000000000344",{"id":24,"text":1300,"url":24,"identifiers":1301},"Chung, 2016, Prevalence of early posttraumatic seizures in children with moderate to severe traumatic brain injury despite levetiracetam prophylaxis., Pediatr Crit Care Med, 17, 150, 10.1097\u002FPCC.0000000000000588",{"doi":1302},"10.1097\u002FPCC.0000000000000588",{"id":24,"text":1304,"url":24,"identifiers":1305},"Josan, 2006, Early decompressive craniectomy may be effective in the treatment of refractory intracranial hypertension after traumatic brain injury., Childs Nerv Syst, 22, 1268, 10.1007\u002Fs00381-006-0064-0",{"doi":1306},"10.1007\u002Fs00381-006-0064-0",{"id":24,"text":1308,"url":24,"identifiers":1309},"Mhanna, 2015, Outcome of children with severe traumatic brain injury who are treated with decompressive craniectomy., J Neurosurg Pediatr, 1",{},{"id":24,"text":1311,"url":24,"identifiers":1312},"Oluigbo, 2012, Comparison of outcomes following decompressive craniectomy in children with accidental and nonaccidental blunt cranial trauma., J Neurosurg Pediatr, 9, 125, 10.3171\u002F2011.11.PEDS09449",{"doi":1313},"10.3171\u002F2011.11.PEDS09449",{"id":24,"text":1315,"url":24,"identifiers":1316},"Pearl, 2013, Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy., Epilepsia, 54, e135, 10.1111\u002Fepi.12326",{"doi":1317},"10.1111\u002Fepi.12326",{"id":24,"text":1319,"url":24,"identifiers":1320},"Roumeliotis, 2016, Hyperosmolar therapy in pediatric traumatic brain injury: A retrospective study., Childs Nerv Syst, 32, 2363, 10.1007\u002Fs00381-016-3231-y",{"doi":1321},"10.1007\u002Fs00381-016-3231-y",{"id":24,"text":1323,"url":24,"identifiers":1324},"Rubiano, 2009, Early decompressive craniectomy for neurotrauma: An institutional experience., Ulus Travma Acil Cerrahi Derg, 15, 28",{},{"id":24,"text":1326,"url":24,"identifiers":1327},"Su, 2012, Increased CSF concentrations of myelin basic protein after TBI in infants and children: Absence of significant effect of therapeutic hypothermia., Neurocrit Care, 17, 401, 10.1007\u002Fs12028-012-9767-0",{"doi":1328},"10.1007\u002Fs12028-012-9767-0",{"id":24,"text":1330,"url":24,"identifiers":1331},"Taylor, 2001, A randomized trial of very early decompressive craniectomy in children with traumatic brain injury and sustained intracranial hypertension., Childs Nerv Syst, 17, 154, 10.1007\u002Fs003810000410",{"doi":1332},"10.1007\u002Fs003810000410",{"id":24,"text":1334,"url":24,"identifiers":1335},"Thomale, 2010, Severe traumatic brain injury in children—a single center experience regarding therapy and long-term outcome., Childs Nerv Syst, 26, 1563, 10.1007\u002Fs00381-010-1103-4",{"doi":1336},"10.1007\u002Fs00381-010-1103-4",{"id":24,"text":1338,"url":24,"identifiers":1339},"Adelson, 2012, Common data elements for pediatric traumatic brain injury: Recommendations from the working group on demographics and clinical assessment., J Neurotrauma, 29, 639, 10.1089\u002Fneu.2011.1952",{"doi":1340},"10.1089\u002Fneu.2011.1952",{"id":24,"text":1342,"url":24,"identifiers":1343},"Berger, 2012, Common data elements for pediatric traumatic brain injury: Recommendations from the biospecimens and biomarkers workgroup., J Neurotrauma, 29, 672, 10.1089\u002Fneu.2011.1861",{"doi":1344},"10.1089\u002Fneu.2011.1861",{"id":24,"text":1346,"url":24,"identifiers":1347},"Duhaime, 2012, Common data elements for neuroimaging of traumatic brain injury: Pediatric considerations., J Neurotrauma, 29, 629, 10.1089\u002Fneu.2011.1927",{"doi":1348},"10.1089\u002Fneu.2011.1927",{"id":24,"text":1350,"url":24,"identifiers":1351},"McCauley, 2012, Recommendations for the use of common outcome measures in pediatric traumatic brain injury research., J Neurotrauma, 29, 678, 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           \u003Cjats:title>Objectives:\u003C\u002Fjats:title>\n            \u003Cjats:p>To identify associations of severe acute kidney injury early after stage 1 (Norwood) operation with risk of severe acute kidney injury and comorbidities at subsequent palliative stages in patients with hypoplastic left heart syndrome and other single ventricle lesions with left-sided obstruction.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Design:\u003C\u002Fjats:title>\n            \u003Cjats:p>Retrospective cohort study. Severe acute kidney injury defined as Kidney Disease Improving Global Outcomes stage 3.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Setting:\u003C\u002Fjats:title>\n            \u003Cjats:p>Single pediatric cardiac center.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Patients:\u003C\u002Fjats:title>\n            \u003Cjats:p>Infants less than or equal to 28 days old with single ventricle physiology and left-sided obstruction undergoing stage 1 operation between September 2007 and November 2012 (\u003Cjats:italic toggle=\"yes\">n\u003C\u002Fjats:italic> = 136).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Interventions:\u003C\u002Fjats:title>\n            \u003Cjats:p>None.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Measurements and Main Results:\u003C\u002Fjats:title>\n            \u003Cjats:p>The occurrence rate of severe acute kidney injury was 21% (28\u002F136) following stage 1, 12% (12\u002F98) following stage 2 palliation (superior cavo-pulmonary anastomosis), and 10% (7\u002F73) following stage 3 palliation (total cavo-pulmonary anastomosis). Severe acute kidney injury early after stage 1 operation was significantly associated with continuous intravenous loop diuretic infusion, need for extracorporeal membrane oxygenation, and in-hospital death (all \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> < 0.05). Gestational age at birth was associated with severe acute kidney injury at stage 2 (\u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.04) and stage 3 (\u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.01). Severe acute kidney injury at stage 1 was an independent risk factor for severe acute kidney injury at stage 2 (adjusted odds ratio, 4.3; 95% CI, 1.1–16.9; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.04). Development of severe acute kidney injury after stage 1 was associated with longer mechanical ventilation time after stage 3 (\u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.047).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\n            \u003Cjats:p>Severe acute kidney injury after stage 1 palliation was an independent risk factor for developing severe acute kidney injury at stage 2, and was associated with prolonged duration of mechanical ventilation following stage 3. Information on the incidence and associated risk factors for postoperative acute kidney injury in hypoplastic left heart syndrome patients from multiple congenital heart centers is a necessary next step to further understand the long-term burden of severe acute kidney injury after staged palliation.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":1689},"Severe Acute Kidney Injury Following Stage 1 Norwood Palliation: Effect on Outcomes and Risk of Severe Acute Kidney Injury at Subsequent Surgical Stages*",{"VOID":1691},"27099973",{"VOID":1693},"10.1097\u002Fpcc.0000000000000734",[178],"https:\u002F\u002Fjournals.lww.com\u002F00130478-201607000-00004",[1697,1718,1740,1754,1775,1788,1805,1826,1843,1858],{"id":1698,"sortIndex":25,"researcher":24,"roles":1699,"affiliations":1700,"properties":1711},"2217ebb8-f7f8-49b6-923c-eeafd2b36e77",[],[1701],{"id":1702,"sortIndex":25,"affiliation":1703,"properties":24},"6af0668b-2b3e-4ebf-ba7c-afd7c73b79e9",{"id":1704,"createTime":1705,"updateTime":1705,"relativeEntities":1706,"slug":1707,"properties":1708,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"51d5191a-772d-4b94-a6ad-f7e3a2f675a6","2024-10-03T22:19:24.460+00:00",[],"Division-of-Pediatric-Cardiology-Department-of-Pediatrics-and-Communicable-Diseases-C-S-Mott-Children-s-Hospital-University-of-Michigan-Medical-School-Ann-Arbor-MI-",{"title":1709},{"EN":1710},"Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, C.S. 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\u003Cjats:title>Objectives:\u003C\u002Fjats:title>\n            \u003Cjats:p>Children with functional single ventricle undergoing the Fontan operation consume considerable resources. The purpose of this study is to evaluate pre- and intraoperative risk factors for longer hospital stay and to describe the perioperative course at a single institution over a 15-year period.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Design:\u003C\u002Fjats:title>\n            \u003Cjats:p>Retrospective cohort study.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Setting:\u003C\u002Fjats:title>\n            \u003Cjats:p>A single pediatric cardiac ICU.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Patients:\u003C\u002Fjats:title>\n            \u003Cjats:p>All consecutive patients undergoing a first-time Fontan operation from 2000 to 2014.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Interventions:\u003C\u002Fjats:title>\n            \u003Cjats:p>None.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Measurements and Main Results:\u003C\u002Fjats:title>\n            \u003Cjats:p>Prolonged length of stay was defined as hospital stay greater than 75 percentile at our institution after surgery. Of 218 patients who met inclusion criteria, median length of stay was 10 days (interquartile range, 8–14 d); prolonged length of stay was defined greater than or equal to 15 days. Independent pre- and intraoperative risk factors for prolonged length of stay included higher hemoglobin (odds ratio, 1.29; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.003), higher mean pulmonary artery pressure (odds ratio, 1.14; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.037), and lower aortic saturation (odds ratio, 0.92; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.008) in the entire group. When patients with hepatic vein inclusion (following previous Kawashima) were excluded, higher hemoglobin (odds ratio, 1.24; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.027), lower aortic saturation (odds ratio, 0.92; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.017), and placement of a fenestration (odds ratio, 2.438; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.021) were associated with prolonged length of stay. Fifty-eight patients (26.6%) had major complications defined by Pediatric Cardiac Critical Care Consortium. Placement of a fenestration (odds ratio, 2.297; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.014) and longer aortic cross-clamp time (odds ratio, 1.015; \u003Cjats:italic toggle=\"yes\">p\u003C\u002Fjats:italic> = 0.003) were independently associated with Pediatric Cardiac Critical Care Consortium major complications.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\n            \u003Cjats:p>In this series, 75% of patients had a postoperative length of stay less than or equal to 2 weeks. Preoperative factors suggesting worse hypoxemia\u002Fdecreased pulmonary blood flow (higher hemoglobin and lower oxygen saturation) and increased pulmonary artery pressure were associated with prolonged length of stay. These findings may help risk stratify this complex patient population, provide more accurate family counseling, and provide preliminary data for changes in preoperative timing of the Fontan and\u002For changes to postoperative management strategies for those at high risk for increased ICU morbidity.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":2850},"Risk Factors for Longer Hospital Stay Following the Fontan Operation",{"VOID":2852},"26927939",{"VOID":2854},"10.1097\u002Fpcc.0000000000000701","2024-10-10T16:25:27.656+00:00",[178],"https:\u002F\u002Fjournals.lww.com\u002F00130478-201605000-00005",[2859,2888,2911,2934,2949,2964,2987,3008,3029,3044,3061],{"id":2860,"sortIndex":312,"researcher":24,"roles":2861,"affiliations":2862,"properties":2883},"3d6fa88c-025a-4329-8e50-bfda2d5d25ed",[],[2863,2873],{"id":2864,"sortIndex":25,"affiliation":2865,"properties":24},"f5a42125-0b77-4dde-87a7-b73cb8e0ae33",{"id":2866,"createTime":2867,"updateTime":2867,"relativeEntities":2868,"slug":2869,"properties":2870,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"92d25e47-4b43-4b23-95b1-9a3b99c1e2f3","2024-10-10T16:25:27.672+00:00",[],"Department-of-Cardiology-The-Heart-Program-at-Nicklaus-Children-s-Hospital-Miami-Children-s-Health-System-Miami-FL-",{"title":2871},{"EN":2872},"Department of Cardiology, The Heart Program at Nicklaus Children's Hospital, Miami Children's Health System, Miami, FL.",{"id":2874,"sortIndex":73,"affiliation":2875,"properties":24},"d8786120-106b-4bbe-a267-009f96bdb3c4",{"id":2876,"createTime":2877,"updateTime":2877,"relativeEntities":2878,"slug":2879,"properties":2880,"entityType":53,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"f001e01a-6808-49af-8762-ca3e71650d3f","2024-10-10T16:25:27.687+00:00",[],"Herbert-Wertheim-School-of-Medicine-Florida-International-University-Miami-FL-",{"title":2881},{"EN":2882},"Herbert Wertheim School of Medicine, Florida International University, Miami, FL.",{"openalex":2884,"title":2886},{"VOID":2885},"A5082336817",{"EN":2887},"Redmond P. 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1971, Surgical repair of tricuspid atresia., Thorax, 26, 240, 10.1136\u002Fthx.26.3.240",{"doi":3116},"10.1136\u002Fthx.26.3.240",{"id":24,"text":3118,"url":24,"identifiers":3119},"Kreutzer, 1973, An operation for the correction of tricuspid atresia., J Thorac Cardiovasc Surg, 66, 613, 10.1016\u002FS0022-5223(19)40598-9",{"doi":3120},"10.1016\u002FS0022-5223(19)40598-9",{"id":24,"text":3122,"url":24,"identifiers":3123},"Kreutzer, 2013, Reflections on five decades of the Fontan Kreutzer procedure., Front Pediatr, 1, 45, 10.3389\u002Ffped.2013.00045",{"doi":3124},"10.3389\u002Ffped.2013.00045",{"id":24,"text":3126,"url":24,"identifiers":3127},"Wolff, 2014, Trends in mortality (1975–2011) after one- and two-stage Fontan surgery, including bidirectional Glenn through Fontan completion., Eur J Cardiothorac Surg, 45, 602, 10.1093\u002Fejcts\u002Fezt461",{"doi":3128},"10.1093\u002Fejcts\u002Fezt461",{"id":24,"text":3130,"url":24,"identifiers":3131},"Gentles, 1997, Fontan operation in five hundred consecutive patients: Factors influencing early and late outcome., J Thorac Cardiovasc Surg, 114, 376, 10.1016\u002FS0022-5223(97)70183-1",{"doi":3132},"10.1016\u002FS0022-5223(97)70183-1",{"id":24,"text":3134,"url":24,"identifiers":3135},"Brown, 2003, Risk factors for long intensive care unit stay after cardiopulmonary bypass in children., Crit Care Med, 31, 28, 10.1097\u002F00003246-200301000-00004",{"doi":3136},"10.1097\u002F00003246-200301000-00004",{"id":24,"text":3138,"url":24,"identifiers":3139},"Pagowska-Klimek, 2011, Predictors of long intensive care unit stay following cardiac surgery in children., Eur J Cardiothorac Surg, 40, 179, 10.1016\u002Fj.ejcts.2010.11.038",{"doi":3140},"10.1016\u002Fj.ejcts.2010.11.038",{"id":24,"text":3142,"url":24,"identifiers":3143},"Marcin, 2001, Long-stay patients in the pediatric intensive care unit., Crit Care Med, 29, 652, 10.1097\u002F00003246-200103000-00035",{"doi":3144},"10.1097\u002F00003246-200103000-00035",{"id":24,"text":3146,"url":24,"identifiers":3147},"Pasquali, 2014, Excess costs associated with complications and prolonged length of stay after congenital heart surgery., Ann Thorac Surg, 98, 1660, 10.1016\u002Fj.athoracsur.2014.06.032",{"doi":3148},"10.1016\u002Fj.athoracsur.2014.06.032",{"id":24,"text":3150,"url":24,"identifiers":3151},"Newburger, 2003, Length of stay after infant heart surgery is related to cognitive outcome at age 8 years., J Pediatr, 143, 67, 10.1016\u002FS0022-3476(03)00183-5",{"doi":3152},"10.1016\u002FS0022-3476(03)00183-5",{"id":24,"text":3154,"url":24,"identifiers":3155},"Marino, 2012, Neurodevelopmental outcomes in children with congenital heart disease: Evaluation and management: A scientific statement from the American Heart Association., Circulation, 126, 1143, 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