[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_a6e2bdcd-7af7-4042-b9d1-e780e7da4f68":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:a6e2bdcd-7af7-4042-b9d1-e780e7da4f68,\"}":95},{"code":4,"data":5,"meta":24},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":26,"manageAffiliations":59,"indexDatabases":71,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},"a6e2bdcd-7af7-4042-b9d1-e780e7da4f68","2023-05-29T11:51:18.090+00:00","2025-11-21T10:05:30.312+00:00",[],"Oxidative-Medicine-and-Cellular-Longevity",{"country":12,"issn":14,"introduce":16,"eissn":18,"title":20},{"VOID":13},"US",{"VOID":15},"19420994",{"EN":17},"Oxidative Medicine and Cellular Longevity is a unique peer-reviewed journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in today’s scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering “bench to bedside” research into clinical strategies.",{"VOID":19},"19420900",{"EN":21},"Oxidative Medicine and Cellular Longevity","PUBLISHER","PENDING",null,0,[27,35,43,51],{"id":28,"createTime":29,"updateTime":30,"relativeEntities":31,"label":32,"description":34,"parentId":24,"standard":24,"scholarHubFieldId":24},"131e254e-0b02-478f-aa3e-0b27d8c7b9d1","2023-05-29T10:24:28.895+00:00","2023-11-21T07:54:54.939+00:00",[],{"EN":33},"Cell Biology",{},{"id":36,"createTime":37,"updateTime":38,"relativeEntities":39,"label":40,"description":42,"parentId":24,"standard":24,"scholarHubFieldId":24},"d76fbb41-9ab4-4d15-9c02-a6f9918892d8","2023-05-29T10:27:02.893+00:00","2023-11-21T06:47:00.767+00:00",[],{"EN":41},"Aging",{},{"id":44,"createTime":45,"updateTime":46,"relativeEntities":47,"label":48,"description":50,"parentId":24,"standard":24,"scholarHubFieldId":24},"0254e3e5-c28d-4a33-83da-81bc94d29ffd","2023-05-29T10:24:00.931+00:00","2023-11-21T07:56:41.438+00:00",[],{"EN":49},"Medicine (miscellaneous)",{},{"id":52,"createTime":53,"updateTime":54,"relativeEntities":55,"label":56,"description":58,"parentId":24,"standard":24,"scholarHubFieldId":24},"73d2c682-bae9-48e0-a003-8e0ed8c9715d","2023-05-29T10:24:27.365+00:00","2023-11-21T07:48:23.815+00:00",[],{"EN":57},"Biochemistry",{},[60],{"id":61,"createTime":62,"updateTime":63,"relativeEntities":64,"slug":65,"properties":66,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"url":24,"parentIds":70,"statistic":24},"2d86e554-8832-49eb-9016-2d6b09abc922","2023-05-29T10:24:06.901+00:00","2025-11-21T10:06:21.095+00:00",[],"Hindawi-Publishing-Corporation",{"title":67},{"EN":68},"Hindawi Publishing Corporation","AFFILIATION",[],[72],{"id":73,"indexDatabase":74,"url":86,"indexYears":87,"academicFieldIds":88,"indexDatabaseRanking":93},"b2b6451d-e4bc-49d7-8d87-a8fc7d3141ea",{"id":75,"createTime":76,"updateTime":77,"relativeEntities":78,"label":79,"description":81,"key":83,"publicationTags":84,"standard":24},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":80,"VI":80},"Scopus - Elsevier",{"EN":80,"VI":82},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[85],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F19700175026","2008-2024",[89,90,91,92],"e89cebf4-fecf-4b74-8ab4-88fca891e4c2","5b1a613c-f8d0-45b5-8ad0-681d8cd14875","578ed71b-dd6b-46c6-8851-2657dbd3629e","d2139bd1-2fdb-481b-a416-9c30dd0cc173","NONE","https:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fomcl\u002F",{"meta":96,"data":98},{"total":97},"102",[99,396,716,1452,2205,2657,2977,3704,4184,4529],{"id":100,"createTime":101,"updateTime":101,"relativeEntities":102,"slug":103,"properties":104,"entityType":120,"verifyStatus":121,"verifyTime":101,"verifyNote":122,"syncStatus":23,"languages":123,"translateLanguages":24,"viewCount":25,"primaryUrl":125,"fullTextUrl":24,"authors":126,"publicationType":220,"publisherRelationship":221,"citationCount":245,"citationInfo":246,"publishDate":250,"publishYear":251,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":252,"isForceReanalyzing":395},"a7e42641-5d17-46b3-88ed-4a7c29a5e944","2024-10-13T23:33:07.123+00:00",[],"Effects-of-Resveratrol-on-Vitrified-Porcine-Oocytes",{"mag":105,"keywords":107,"pmc":108,"openalex":110,"abstract":112,"title":114,"pm":116,"doi":118},{"VOID":106},"1994761571",{},{"VOID":109},"3816072",{"VOID":111},"W1994761571",{"EN":113},"\u003Cjats:p>Vitrified MII porcine oocytes are characterized by reduced developmental competence, associated with the activation of the apoptotic pathway. Resveratrol (R), a polyphenolic compound present in several vegetal sources, has been reported to exert, among all its other biological effects, an antiapoptotic one. The aim of this study was to determine the effects of R (2 \u003Cjats:italic>µ\u003C\u002Fjats:italic>M) on the apoptotic status of porcine oocytes vitrified by Cryotop method, evaluating phosphatidylserine (PS) exteriorization and caspases activation. R was added during IVM (A); 2 h postwarming incubation (B); vitrification\u002Fwarming and 2 h postwarming incubation (C); all previous phases (D). Data on PS exteriorization showed, in each treated group, a significantly higher (\u003Cmml:math xmlns:mml=\"http:\u002F\u002Fwww.w3.org\u002F1998\u002FMath\u002FMathML\" id=\"M1\">\u003Cmml:mi>P\u003C\u002Fmml:mi>\u003Cmml:mo><\u003C\u002Fmml:mo>\u003Cmml:mn>0.05\u003C\u002Fmml:mn>\u003C\u002Fmml:math>) percentage of live nonapoptotic oocytes as compared with CTR; moreover, the percentage of live apoptotic oocytes was significantly (\u003Cmml:math xmlns:mml=\"http:\u002F\u002Fwww.w3.org\u002F1998\u002FMath\u002FMathML\" id=\"M2\">\u003Cmml:mi>P\u003C\u002Fmml:mi>\u003Cmml:mo><\u003C\u002Fmml:mo>\u003Cmml:mn>0.05\u003C\u002Fmml:mn>\u003C\u002Fmml:math>) lower in all R-treated groups relative to CTR. The results on caspase activation showed a tendency to an increase of viable oocytes with inactive caspases in B, C, and D, while a significant (\u003Cmml:math xmlns:mml=\"http:\u002F\u002Fwww.w3.org\u002F1998\u002FMath\u002FMathML\" id=\"M3\">\u003Cmml:mi>P\u003C\u002Fmml:mi>\u003Cmml:mo><\u003C\u002Fmml:mo>\u003Cmml:mn>0.05\u003C\u002Fmml:mn>\u003C\u002Fmml:math>) increase in A compared to CTR was recorded. These data demonstrate that R supplementation in various phases of IVM and vitrification\u002Fwarming procedure can modulate the apoptotic process, improving the resistance of porcine oocytes to cryopreservation-induced damage.\u003C\u002Fjats:p>",{"EN":115},"Effects of Resveratrol on Vitrified Porcine Oocytes",{"VOID":117},"24223236",{"VOID":119},"10.1155\u002F2013\u002F920257","PUBLICATION","VERIFIED","Auto Verify",[124],"EN","http:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fomcl\u002F2013\u002F920257\u002F",[127,149,167,185,202],{"id":128,"sortIndex":129,"researcher":24,"roles":130,"affiliations":131,"properties":142},"26c91891-6c98-4caf-bdf9-15129351dc79",3,[],[132],{"id":133,"sortIndex":25,"affiliation":134,"properties":24},"bd7c2fba-ddce-4c06-bd30-b8f45968c702",{"id":135,"createTime":136,"updateTime":136,"relativeEntities":137,"slug":138,"properties":139,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b0885ed5-32f9-4644-9b72-d5b6f9251fae","2024-10-13T23:33:07.139+00:00",[],"Dipartimento-di-Scienze-Mediche-Veterinarie-DIMEVET-Universit%C3%A0-di-Bologna-Via-Tolara-di-Sopra-50-40064-Ozzano-dell-Emilia-Bologna-Italy",{"title":140},{"EN":141},"Dipartimento di Scienze Mediche Veterinarie (DIMEVET), Università di Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell’Emilia, Bologna, Italy",{"openalex":143,"orcid":145,"title":147},{"VOID":144},"A5038989092",{"VOID":146},"https:\u002F\u002Forcid.org\u002F0000-0001-5795-9851",{"EN":148},"Carlo Tamanini",{"id":150,"sortIndex":151,"researcher":24,"roles":152,"affiliations":153,"properties":160},"7a5ebc47-de96-4930-917d-06f0e78789d7",2,[],[154],{"id":155,"sortIndex":25,"affiliation":156,"properties":24},"2d9c17b3-da53-4cb5-8af4-8a4aba1f8ba8",{"id":135,"createTime":136,"updateTime":136,"relativeEntities":157,"slug":138,"properties":158,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":159},{"EN":141},{"openalex":161,"orcid":163,"title":165},{"VOID":162},"A5038428494",{"VOID":164},"https:\u002F\u002Forcid.org\u002F0000-0001-6276-2674",{"EN":166},"Diego Bucci",{"id":168,"sortIndex":169,"researcher":24,"roles":170,"affiliations":171,"properties":178},"84c989bd-080b-4f17-9d8a-75793a7689bb",1,[],[172],{"id":173,"sortIndex":25,"affiliation":174,"properties":24},"700b368e-e653-4b3d-a18b-091ffbe5cf1d",{"id":135,"createTime":136,"updateTime":136,"relativeEntities":175,"slug":138,"properties":176,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":177},{"EN":141},{"openalex":179,"orcid":181,"title":183},{"VOID":180},"A5051325446",{"VOID":182},"https:\u002F\u002Forcid.org\u002F0000-0002-8934-9035",{"EN":184},"Marcella Spinaci",{"id":186,"sortIndex":25,"researcher":24,"roles":187,"affiliations":188,"properties":195},"224b1e6a-353a-4bc0-9e71-f82a9e6ff6ac",[],[189],{"id":190,"sortIndex":25,"affiliation":191,"properties":24},"b3d7b0c0-32ea-41e2-be0e-278d35955a9c",{"id":135,"createTime":136,"updateTime":136,"relativeEntities":192,"slug":138,"properties":193,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":194},{"EN":141},{"openalex":196,"orcid":198,"title":200},{"VOID":197},"A5075003730",{"VOID":199},"https:\u002F\u002Forcid.org\u002F0000-0002-0095-0554",{"EN":201},"Elisa Giaretta",{"id":203,"sortIndex":204,"researcher":24,"roles":205,"affiliations":206,"properties":213},"c859d8a2-281d-440c-80a2-022555d0fad0",4,[],[207],{"id":208,"sortIndex":25,"affiliation":209,"properties":24},"2b7eabb3-6a3d-45fb-a03d-dcdfba0979c8",{"id":135,"createTime":136,"updateTime":136,"relativeEntities":210,"slug":138,"properties":211,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":212},{"EN":141},{"openalex":214,"orcid":216,"title":218},{"VOID":215},"A5022317480",{"VOID":217},"https:\u002F\u002Forcid.org\u002F0000-0001-5149-108X",{"EN":219},"Giovanna Galeati","ARTICLE",{"url":24,"publisher":222,"properties":240},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":223,"slug":10,"properties":224,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":230,"manageAffiliations":231,"indexDatabases":232,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":225,"issn":226,"introduce":227,"eissn":228,"title":229},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[233],{"id":73,"indexDatabase":234,"url":86,"indexYears":87,"academicFieldIds":239,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":235,"label":236,"description":237,"key":83,"publicationTags":238,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":241,"pages":243},{"VOID":242},"2013",{"VOID":244},"1-7",43,{"total":245,"publishYear":24,"statisticByYear":247},{"2015":129,"2016":151,"2017":204,"2018":248,"2019":249,"2020":248,"2021":204,"2022":169,"2023":129,"2024":129},7,9,"2013-01-01",2013,[253,256,259,262,265,268,271,274,277,280,283,286,289,292,295,298,301,304,307,311,314,317,321,324,327,330,333,336,339,342,346,350,353,357,361,364,367,370,373,376,379,382,385,388,391],{"id":24,"text":254,"url":24,"identifiers":255},"10.1186\u002F1757-2215-6-30",{"doi":254},{"id":24,"text":257,"url":24,"identifiers":258},"10.1016\u002Fj.cryobiol.2010.05.002",{"doi":257},{"id":24,"text":260,"url":24,"identifiers":261},"10.1016\u002Fj.theriogenology.2012.06.008",{"doi":260},{"id":24,"text":263,"url":24,"identifiers":264},"10.1016\u002Fj.cryobiol.2005.08.002",{"doi":263},{"id":24,"text":266,"url":24,"identifiers":267},"10.1016\u002Fj.theriogenology.2006.09.014",{"doi":266},{"id":24,"text":269,"url":24,"identifiers":270},"10.1016\u002Fj.ejogrb.2013.05.004",{"doi":269},{"id":24,"text":272,"url":24,"identifiers":273},"10.1016\u002Fj.theriogenology.2011.08.028",{"doi":272},{"id":24,"text":275,"url":24,"identifiers":276},"10.1111\u002Fj.1439-0531.2007.00899.x",{"doi":275},{"id":24,"text":278,"url":24,"identifiers":279},"10.1046\u002Fj.1439-0531.2001.00248.x",{"doi":278},{"id":24,"text":281,"url":24,"identifiers":282},"10.1016\u002Fj.anireprosci.2011.07.010",{"doi":281},{"id":24,"text":284,"url":24,"identifiers":285},"10.1016\u002Fj.anireprosci.2012.08.020",{"doi":284},{"id":24,"text":287,"url":24,"identifiers":288},"10.1095\u002Fbiolreprod.108.070235",{"doi":287},{"id":24,"text":290,"url":24,"identifiers":291},"10.1016\u002Fj.fertnstert.2010.01.043",{"doi":290},{"id":24,"text":293,"url":24,"identifiers":294},"10.1016\u002Fj.anireprosci.2006.06.020",{"doi":293},{"id":24,"text":296,"url":24,"identifiers":297},"10.1262\u002Fjrd.11-140N",{"doi":296},{"id":24,"text":299,"url":24,"identifiers":300},"10.1016\u002Fj.cryobiol.2007.06.008",{"doi":299},{"id":24,"text":302,"url":24,"identifiers":303},"10.1007\u002Fs10495-005-0367-8",{"doi":302},{"id":24,"text":305,"url":24,"identifiers":306},"10.1016\u002Fj.bbamcr.2012.06.019",{"doi":305},{"id":24,"text":308,"url":24,"identifiers":309},"1992, Journal of Immunology, 148, 2207, 10.4049\u002Fjimmunol.148.7.2207",{"doi":310},"10.4049\u002Fjimmunol.148.7.2207",{"id":24,"text":312,"url":24,"identifiers":313},"10.1006\u002Fbbrc.1998.8663",{"doi":312},{"id":24,"text":315,"url":24,"identifiers":316},"2001, Journal of Cell Biology, 155, 649",{},{"id":24,"text":318,"url":24,"identifiers":319},"2002, Human Reproduction, 17, 2686, 10.1093\u002Fhumrep\u002F17.10.2686",{"doi":320},"10.1093\u002Fhumrep\u002F17.10.2686",{"id":24,"text":322,"url":24,"identifiers":323},"10.1016\u002Fj.theriogenology.2008.01.005",{"doi":322},{"id":24,"text":325,"url":24,"identifiers":326},"10.1016\u002Fj.theriogenology.2010.04.002",{"doi":325},{"id":24,"text":328,"url":24,"identifiers":329},"Journal of Veterinary Medical Science, 75, 1279",{},{"id":24,"text":331,"url":24,"identifiers":332},"10.1016\u002Fj.theriogenology.2012.01.024",{"doi":331},{"id":24,"text":334,"url":24,"identifiers":335},"10.1002\u002Fiub.47",{"doi":334},{"id":24,"text":337,"url":24,"identifiers":338},"10.1089\u002Fars.2008.2412",{"doi":337},{"id":24,"text":340,"url":24,"identifiers":341},"10.1095\u002Fbiolreprod57.1.49",{"doi":340},{"id":24,"text":343,"url":24,"identifiers":344},"2005, Reproductive BioMedicine Online, 11, 300, 10.1016\u002FS1472-6483(10)60837-1",{"doi":345},"10.1016\u002FS1472-6483(10)60837-1",{"id":24,"text":347,"url":24,"identifiers":348},"2005, Reproductive BioMedicine Online, 11, 608, 10.1016\u002FS1472-6483(10)61169-8",{"doi":349},"10.1016\u002FS1472-6483(10)61169-8",{"id":24,"text":351,"url":24,"identifiers":352},"2012",{},{"id":24,"text":354,"url":24,"identifiers":355},"1999, Journal of Immunology, 163, 4115, 10.4049\u002Fjimmunol.163.8.4115",{"doi":356},"10.4049\u002Fjimmunol.163.8.4115",{"id":24,"text":358,"url":24,"identifiers":359},"2000, Cell Death and Differentiation, 7, 282, 10.1038\u002Fsj.cdd.4400646",{"doi":360},"10.1038\u002Fsj.cdd.4400646",{"id":24,"text":362,"url":24,"identifiers":363},"10.1016\u002Fj.vetimm.2013.02.003",{"doi":362},{"id":24,"text":365,"url":24,"identifiers":366},"10.1074\u002Fjbc.M207781200",{"doi":365},{"id":24,"text":368,"url":24,"identifiers":369},"10.1095\u002Fbiolreprod.104.029264",{"doi":368},{"id":24,"text":371,"url":24,"identifiers":372},"2005, Reproductive Biology, 5, 5",{},{"id":24,"text":374,"url":24,"identifiers":375},"10.1262\u002Fjrd.09-214H",{"doi":374},{"id":24,"text":377,"url":24,"identifiers":378},"10.1016\u002FS0024-3205(97)00883-7",{"doi":377},{"id":24,"text":380,"url":24,"identifiers":381},"10.1016\u002Fj.bbrc.2003.08.105",{"doi":380},{"id":24,"text":383,"url":24,"identifiers":384},"10.1152\u002Fajplung.00361.2007",{"doi":383},{"id":24,"text":386,"url":24,"identifiers":387},"10.1007\u002Fs11130-010-0154-8",{"doi":386},{"id":24,"text":389,"url":24,"identifiers":390},"10.1124\u002Fjpet.110.171983",{"doi":389},{"id":24,"text":392,"url":24,"identifiers":393},"1998, Journal of Neurochemistry, 71, 1854, 10.1046\u002Fj.1471-4159.1998.71051854.x",{"doi":394},"10.1046\u002Fj.1471-4159.1998.71051854.x",false,{"id":397,"createTime":398,"updateTime":398,"relativeEntities":399,"slug":400,"properties":401,"entityType":120,"verifyStatus":121,"verifyTime":398,"verifyNote":122,"syncStatus":23,"languages":417,"translateLanguages":24,"viewCount":25,"primaryUrl":418,"fullTextUrl":24,"authors":419,"publicationType":220,"publisherRelationship":441,"citationCount":464,"citationInfo":465,"publishDate":250,"publishYear":251,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":470,"isForceReanalyzing":395},"552ef368-7722-48e7-a41b-c3df7a717661","2025-01-29T23:25:38.862+00:00",[],"The-Triggering-Receptor-Expressed-on-Myeloid-Cells-2-TREM-ming-the-Inflammatory-Component-Associated-with-Alzheimer-s-Disease",{"mag":402,"keywords":404,"pmc":405,"openalex":407,"abstract":409,"title":411,"pm":413,"doi":415},{"VOID":403},"2025455915",{},{"VOID":406},"3606781",{"VOID":408},"W2025455915",{"EN":410},"\u003Cjats:p>Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive loss of memory and cognitive skills. Although much attention has been devoted concerning the contribution of the microscopic lesions, senile plaques, and neurofibrillary tangles to the disease process, inflammation has long been suspected to play a major role in the etiology of AD. Recently, a novel variant in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has been identified that has refocused the spotlight back onto inflammation as a major contributing factor in AD. Variants in TREM2 triple one's risk of developing late-onset AD. TREM2 is expressed on microglial cells, the resident macrophages in the CNS, and functions to stimulate phagocytosis on one hand and to suppress cytokine production and inflammation on the other hand. The purpose of this paper is to discuss these recent developments including the potential role that TREM2 normally plays and how loss of function may contribute to AD pathogenesis by enhancing oxidative stress and inflammation within the CNS. In this context, an overview of the pathways linking beta-amyloid, neurofibrillary tangles (NFTs), oxidative stress, and inflammation will be discussed.\u003C\u002Fjats:p>",{"EN":412},"The Triggering Receptor Expressed on Myeloid Cells 2: “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease",{"VOID":414},"23533697",{"VOID":416},"10.1155\u002F2013\u002F860959",[124],"http:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fomcl\u002F2013\u002F860959\u002F",[420],{"id":421,"sortIndex":25,"researcher":24,"roles":422,"affiliations":423,"properties":434},"054249e8-f81a-4686-a8f4-c26abb6555cc",[],[424],{"id":425,"sortIndex":25,"affiliation":426,"properties":24},"6a8e1518-8203-45bd-8e36-cc3175af81d0",{"id":427,"createTime":428,"updateTime":428,"relativeEntities":429,"slug":430,"properties":431,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5c45dc83-aa26-4413-bfb1-2804fde401c0","2025-01-29T23:25:38.881+00:00",[],"Department-of-Biological-Sciences-Boise-State-University-Science-Building-Room-228-Boise-ID-83725-USA",{"title":432},{"EN":433},"Department of Biological Sciences, Boise State University, Science Building, Room 228, Boise, ID 83725, USA",{"openalex":435,"orcid":437,"title":439},{"VOID":436},"A5042512732",{"VOID":438},"https:\u002F\u002Forcid.org\u002F0000-0002-8406-1956",{"EN":440},"Troy T. Rohn",{"url":24,"publisher":442,"properties":460},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":443,"slug":10,"properties":444,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":450,"manageAffiliations":451,"indexDatabases":452,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":445,"issn":446,"introduce":447,"eissn":448,"title":449},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[453],{"id":73,"indexDatabase":454,"url":86,"indexYears":87,"academicFieldIds":459,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":455,"label":456,"description":457,"key":83,"publicationTags":458,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":461,"pages":462},{"VOID":242},{"VOID":463},"1-8",44,{"total":464,"publishYear":24,"statisticByYear":466},{"2014":467,"2015":468,"2016":151,"2017":204,"2018":204,"2019":129,"2020":129,"2021":469,"2022":204,"2023":129,"2024":151},6,8,5,[471,474,477,480,483,486,489,492,495,498,502,506,509,512,515,519,522,525,528,531,535,539,542,545,549,552,556,559,562,565,569,572,575,579,582,585,588,592,595,598,602,605,608,611,614,617,621,624,628,631,635,639,642,645,648,651,654,657,661,664,667,670,673,677,680,683,686,689,692,695,698,701,704,707,710,713],{"id":24,"text":472,"url":24,"identifiers":473},"10.1016\u002Fj.jalz.2012.02.001",{"doi":472},{"id":24,"text":475,"url":24,"identifiers":476},"10.1159\u002F000109998",{"doi":475},{"id":24,"text":478,"url":24,"identifiers":479},"2012, Frontiers in Neurology, 3, 63",{},{"id":24,"text":481,"url":24,"identifiers":482},"10.2174\u002F156720506779025189",{"doi":481},{"id":24,"text":484,"url":24,"identifiers":485},"10.1126\u002Fscience.1072994",{"doi":484},{"id":24,"text":487,"url":24,"identifiers":488},"10.1016\u002Fj.nlm.2011.08.003",{"doi":487},{"id":24,"text":490,"url":24,"identifiers":491},"10.1002\u002F1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M",{"doi":490},{"id":24,"text":493,"url":24,"identifiers":494},"10.1186\u002Falzrt36",{"doi":493},{"id":24,"text":496,"url":24,"identifiers":497},"10.1523\u002FJNEUROSCI.3432-04.2004",{"doi":496},{"id":24,"text":499,"url":24,"identifiers":500},"1998, Proceedings of the National Academy of Sciences of the United States of America, 95, 6448, 10.1073\u002Fpnas.95.11.6448",{"doi":501},"10.1073\u002Fpnas.95.11.6448",{"id":24,"text":503,"url":24,"identifiers":504},"2007, CNS Spectrums, 12, 113, 10.1017\u002FS1092852900020629",{"doi":505},"10.1017\u002FS1092852900020629",{"id":24,"text":507,"url":24,"identifiers":508},"10.1042\u002FBJ20120653",{"doi":507},{"id":24,"text":510,"url":24,"identifiers":511},"10.1038\u002Fnrd3288",{"doi":510},{"id":24,"text":513,"url":24,"identifiers":514},"10.1016\u002F0896-6273(93)90057-X",{"doi":513},{"id":24,"text":516,"url":24,"identifiers":517},"2000, Annals of the New York Academy of Sciences, 924, 62, 10.1111\u002Fj.1749-6632.2000.tb05561.x",{"doi":518},"10.1111\u002Fj.1749-6632.2000.tb05561.x",{"id":24,"text":520,"url":24,"identifiers":521},"10.1073\u002Fpnas.121119298",{"doi":520},{"id":24,"text":523,"url":24,"identifiers":524},"10.1016\u002Fj.molmed.2005.02.008",{"doi":523},{"id":24,"text":526,"url":24,"identifiers":527},"10.1155\u002F2012\u002F369808",{"doi":526},{"id":24,"text":529,"url":24,"identifiers":530},"10.1016\u002Fj.neurobiolaging.2003.09.001",{"doi":529},{"id":24,"text":532,"url":24,"identifiers":533},"2004, Neurology, 63, 1155, 10.1212\u002F01.WNL.0000140626.48118.0A",{"doi":534},"10.1212\u002F01.WNL.0000140626.48118.0A",{"id":24,"text":536,"url":24,"identifiers":537},"1994, NeuroReport, 5, 2529, 10.1097\u002F00001756-199412000-00031",{"doi":538},"10.1097\u002F00001756-199412000-00031",{"id":24,"text":540,"url":24,"identifiers":541},"10.1007\u002FBF02740836",{"doi":540},{"id":24,"text":543,"url":24,"identifiers":544},"10.1006\u002Fexnr.2000.7340",{"doi":543},{"id":24,"text":546,"url":24,"identifiers":547},"1999, American Journal of Pathology, 155, 1459, 10.1016\u002FS0002-9440(10)65460-0",{"doi":548},"10.1016\u002FS0002-9440(10)65460-0",{"id":24,"text":550,"url":24,"identifiers":551},"10.1016\u002FS0006-8993(01)02018-2",{"doi":550},{"id":24,"text":553,"url":24,"identifiers":554},"1999, Journal of Neuropathology and Experimental Neurology, 58, 1020, 10.1097\u002F00005072-199909000-00012",{"doi":555},"10.1097\u002F00005072-199909000-00012",{"id":24,"text":557,"url":24,"identifiers":558},"10.1006\u002Fnbdi.2001.0449",{"doi":557},{"id":24,"text":560,"url":24,"identifiers":561},"10.1006\u002Fnbdi.2002.0549",{"doi":560},{"id":24,"text":563,"url":24,"identifiers":564},"10.1074\u002Fjbc.274.33.23426",{"doi":563},{"id":24,"text":566,"url":24,"identifiers":567},"2004, American Journal of Pathology, 165, 523, 10.1016\u002FS0002-9440(10)63317-2",{"doi":568},"10.1016\u002FS0002-9440(10)63317-2",{"id":24,"text":570,"url":24,"identifiers":571},"10.1073\u002Fpnas.1630428100",{"doi":570},{"id":24,"text":573,"url":24,"identifiers":574},"10.1172\u002FJCI200420640",{"doi":573},{"id":24,"text":576,"url":24,"identifiers":577},"1999, Cell, 97, 395, 10.1016\u002FS0092-8674(00)80748-5",{"doi":578},"10.1016\u002FS0092-8674(00)80748-5",{"id":24,"text":580,"url":24,"identifiers":581},"10.1016\u002Fj.nbd.2010.11.003",{"doi":580},{"id":24,"text":583,"url":24,"identifiers":584},"10.2353\u002Fajpath.2006.050798",{"doi":583},{"id":24,"text":586,"url":24,"identifiers":587},"10.1523\u002FJNEUROSCI.3072-08.2008",{"doi":586},{"id":24,"text":589,"url":24,"identifiers":590},"1994, Proceedings of the National Academy of Sciences of the United States of America, 91, 3270, 10.1073\u002Fpnas.91.8.3270",{"doi":591},"10.1073\u002Fpnas.91.8.3270",{"id":24,"text":593,"url":24,"identifiers":594},"10.1006\u002Fjsbi.2000.4274",{"doi":593},{"id":24,"text":596,"url":24,"identifiers":597},"10.1080\u002F1071576021000049890",{"doi":596},{"id":24,"text":599,"url":24,"identifiers":600},"2012, Journal of Alzheimer's Disease, 28, 855, 10.3233\u002FJAD-2011-111172",{"doi":601},"10.3233\u002FJAD-2011-111172",{"id":24,"text":603,"url":24,"identifiers":604},"10.1007\u002Fs12017-011-8155-9",{"doi":603},{"id":24,"text":606,"url":24,"identifiers":607},"10.1002\u002Fjnr.10525",{"doi":606},{"id":24,"text":609,"url":24,"identifiers":610},"10.1046\u002Fj.1471-4159.2000.0751234.x",{"doi":609},{"id":24,"text":612,"url":24,"identifiers":613},"10.1046\u002Fj.1471-4159.1999.0720751.x",{"doi":612},{"id":24,"text":615,"url":24,"identifiers":616},"10.1016\u002FS0014-5793(00)02323-1",{"doi":615},{"id":24,"text":618,"url":24,"identifiers":619},"2000, Journal of Neuropathology and Experimental Neurology, 59, 880, 10.1093\u002Fjnen\u002F59.10.880",{"doi":620},"10.1093\u002Fjnen\u002F59.10.880",{"id":24,"text":622,"url":24,"identifiers":623},"10.1016\u002FS0047-6374(01)00342-6",{"doi":622},{"id":24,"text":625,"url":24,"identifiers":626},"1996, Journal of Neuropathology and Experimental Neurology, 55, 1083, 10.1097\u002F00005072-199655100-00008",{"doi":627},"10.1097\u002F00005072-199655100-00008",{"id":24,"text":629,"url":24,"identifiers":630},"10.1016\u002F0197-4580(96)00115-7",{"doi":629},{"id":24,"text":632,"url":24,"identifiers":633},"1987, Neuroscience Letters, 79, 195, 10.1016\u002F0304-3940(87)90696-3",{"doi":634},"10.1016\u002F0304-3940(87)90696-3",{"id":24,"text":636,"url":24,"identifiers":637},"2000, Archives of Neurology, 57, 817, 10.1001\u002Farchneur.57.6.817",{"doi":638},"10.1001\u002Farchneur.57.6.817",{"id":24,"text":640,"url":24,"identifiers":641},"10.1126\u002Fscience.286.5448.2352",{"doi":640},{"id":24,"text":643,"url":24,"identifiers":644},"10.1016\u002FS0165-5728(98)00226-4",{"doi":643},{"id":24,"text":646,"url":24,"identifiers":647},"10.1016\u002F0197-4580(96)00109-1",{"doi":646},{"id":24,"text":649,"url":24,"identifiers":650},"1988, Neurobiology of Aging, 9, 339",{},{"id":24,"text":652,"url":24,"identifiers":653},"2012, Cold Spring Harbor Perspectives in Medicine, 2, a006346",{},{"id":24,"text":655,"url":24,"identifiers":656},"10.1038\u002Fnm1484",{"doi":655},{"id":24,"text":658,"url":24,"identifiers":659},"1989, Journal of Neuroimmunology, 24, 173, 10.1016\u002F0165-5728(89)90115-X",{"doi":660},"10.1016\u002F0165-5728(89)90115-X",{"id":24,"text":662,"url":24,"identifiers":663},"10.1016\u002FS0197-4580(00)00219-0",{"doi":662},{"id":24,"text":665,"url":24,"identifiers":666},"10.1016\u002FS0165-5728(98)00188-X",{"doi":665},{"id":24,"text":668,"url":24,"identifiers":669},"10.1007\u002Fs00702-010-0433-4",{"doi":668},{"id":24,"text":671,"url":24,"identifiers":672},"10.1038\u002Fnri1106",{"doi":671},{"id":24,"text":674,"url":24,"identifiers":675},"2000, Journal of Immunology, 164, 4991, 10.4049\u002Fjimmunol.164.10.4991",{"doi":676},"10.4049\u002Fjimmunol.164.10.4991",{"id":24,"text":678,"url":24,"identifiers":679},"10.1084\u002Fjem.20041611",{"doi":678},{"id":24,"text":681,"url":24,"identifiers":682},"10.1038\u002F77153",{"doi":681},{"id":24,"text":684,"url":24,"identifiers":685},"10.1084\u002Fjem.20030027",{"doi":684},{"id":24,"text":687,"url":24,"identifiers":688},"10.1002\u002Feji.200636837",{"doi":687},{"id":24,"text":690,"url":24,"identifiers":691},"10.1371\u002Fjournal.pmed.0040124",{"doi":690},{"id":24,"text":693,"url":24,"identifiers":694},"10.1002\u002Fglia.20710",{"doi":693},{"id":24,"text":696,"url":24,"identifiers":697},"10.1042\u002FAN20100010",{"doi":696},{"id":24,"text":699,"url":24,"identifiers":700},"10.1371\u002Fjournal.pbio.1000527",{"doi":699},{"id":24,"text":702,"url":24,"identifiers":703},"10.1056\u002FNEJMoa1211103",{"doi":702},{"id":24,"text":705,"url":24,"identifiers":706},"10.1056\u002FNEJMoa1211851",{"doi":705},{"id":24,"text":708,"url":24,"identifiers":709},"10.1038\u002F475S20a",{"doi":708},{"id":24,"text":711,"url":24,"identifiers":712},"10.1086\u002F342259",{"doi":711},{"id":24,"text":714,"url":24,"identifiers":715},"10.1001\u002Farchneurol.2013.579",{"doi":714},{"id":717,"createTime":718,"updateTime":718,"relativeEntities":719,"slug":720,"properties":721,"entityType":120,"verifyStatus":121,"verifyTime":737,"verifyNote":122,"syncStatus":23,"languages":738,"translateLanguages":24,"viewCount":25,"primaryUrl":739,"fullTextUrl":24,"authors":740,"publicationType":220,"publisherRelationship":813,"citationCount":837,"citationInfo":838,"publishDate":843,"publishYear":844,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":845,"isForceReanalyzing":395},"3746e739-7700-4469-b5d2-698c97422418","2024-09-21T22:32:21.498+00:00",[],"The-Tumorigenic-Roles-of-the-Cellular-REDOX-Regulatory-Systems",{"mag":722,"keywords":724,"pmc":725,"openalex":727,"abstract":729,"title":731,"pm":733,"doi":735},{"VOID":723},"1710117369",{},{"VOID":726},"4670861",{"VOID":728},"W1710117369",{"EN":730},"\u003Cjats:p>The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions. Since a large number of chemotherapeutic agents currently used in the clinic rely on the induction of ROS overload or change of ROS quality to kill the tumor, the cancer cell REDOX adaptation represents a significant obstacle to conventional chemotherapy. In this review we will first examine the different factors that contribute to the enhanced oxidative stress generally observed within the tumor microenvironment. We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance. Finally we will make an analysis of commonly used chemotherapeutic drugs that induce ROS. The current knowledge of cancer cell REDOX adaptation raises the issue of developing novel and more effective therapies for these tumors that are usually resistant to conventional ROS inducing chemotherapy.\u003C\u002Fjats:p>",{"EN":732},"The Tumorigenic Roles of the Cellular REDOX Regulatory Systems",{"VOID":734},"26682014",{"VOID":736},"10.1155\u002F2016\u002F8413032","2024-09-21T22:32:21.497+00:00",[124],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1155\u002F2016\u002F8413032",[741,762,779,796],{"id":742,"sortIndex":169,"researcher":24,"roles":743,"affiliations":744,"properties":755},"d696fdbd-62f8-464a-8eb2-349c65364259",[],[745],{"id":746,"sortIndex":25,"affiliation":747,"properties":24},"e4b314f1-7a82-44cc-a202-f212eb8b5b85",{"id":748,"createTime":749,"updateTime":749,"relativeEntities":750,"slug":751,"properties":752,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"aa24dc2a-6307-4b96-adfd-3e912d8ebc93","2024-09-21T22:32:21.517+00:00",[],"Centre-for-Biomedical-Research-CBMR-University-of-Algarve-Campus-of-Gambelas-Building-8-Room-2-22-8055-139-Faro-Portugal",{"title":753},{"EN":754},"Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 2.22, 8055-139 Faro, Portugal",{"openalex":756,"orcid":758,"title":760},{"VOID":757},"A5047674368",{"VOID":759},"https:\u002F\u002Forcid.org\u002F0000-0002-1488-376X",{"EN":761},"Juliana Crês de Freitas",{"id":763,"sortIndex":129,"researcher":24,"roles":764,"affiliations":765,"properties":772},"0485e319-eb5e-489c-9a55-e483ac2e011c",[],[766],{"id":767,"sortIndex":25,"affiliation":768,"properties":24},"ae16d706-f55b-406c-a847-5b9b2e3756dd",{"id":748,"createTime":749,"updateTime":749,"relativeEntities":769,"slug":751,"properties":770,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":771},{"EN":754},{"openalex":773,"orcid":775,"title":777},{"VOID":774},"A5055783244",{"VOID":776},"https:\u002F\u002Forcid.org\u002F0000-0002-4856-3908",{"EN":778},"Patrícia A. Madureira",{"id":780,"sortIndex":151,"researcher":24,"roles":781,"affiliations":782,"properties":789},"44cae1f2-e467-41ef-b0ca-9267c97f7506",[],[783],{"id":784,"sortIndex":25,"affiliation":785,"properties":24},"5c1a574d-cc3c-4d3f-a716-974e668ecc04",{"id":748,"createTime":749,"updateTime":749,"relativeEntities":786,"slug":751,"properties":787,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":788},{"EN":754},{"openalex":790,"orcid":792,"title":794},{"VOID":791},"A5035369433",{"VOID":793},"https:\u002F\u002Forcid.org\u002F0000-0002-4241-0396",{"EN":795},"Nadine V. Conchinha",{"id":797,"sortIndex":25,"researcher":24,"roles":798,"affiliations":799,"properties":806},"0d07ea10-5dbe-4748-a03c-62ef8aaa09cc",[],[800],{"id":801,"sortIndex":25,"affiliation":802,"properties":24},"857dfad6-cd76-4205-807c-ed3e0c00157c",{"id":748,"createTime":749,"updateTime":749,"relativeEntities":803,"slug":751,"properties":804,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":805},{"EN":754},{"openalex":807,"orcid":809,"title":811},{"VOID":808},"A5079229119",{"VOID":810},"https:\u002F\u002Forcid.org\u002F0000-0002-4361-8842",{"EN":812},"Stéphanie A. Castaldo",{"url":24,"publisher":814,"properties":832},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":815,"slug":10,"properties":816,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":822,"manageAffiliations":823,"indexDatabases":824,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":817,"issn":818,"introduce":819,"eissn":820,"title":821},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[825],{"id":73,"indexDatabase":826,"url":86,"indexYears":87,"academicFieldIds":831,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":827,"label":828,"description":829,"key":83,"publicationTags":830,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":833,"issue":835},{"VOID":834},"2016",{"VOID":836},"1",82,{"total":837,"publishYear":24,"statisticByYear":839},{"2016":469,"2017":840,"2018":248,"2019":249,"2020":467,"2021":841,"2022":842,"2023":249,"2024":204},11,15,16,"2016-01-01",2016,[846,849,852,855,858,861,864,867,870,873,876,879,882,885,888,891,894,897,900,903,906,909,912,915,918,921,924,927,930,933,936,939,942,945,948,951,954,957,960,963,966,969,972,975,978,981,984,987,990,993,996,999,1002,1005,1008,1011,1014,1017,1020,1023,1026,1029,1032,1035,1038,1041,1044,1047,1050,1053,1056,1059,1062,1065,1068,1071,1074,1077,1080,1083,1086,1089,1092,1095,1098,1101,1104,1107,1110,1113,1116,1119,1122,1125,1128,1131,1134,1137,1140,1143,1146,1149,1152,1155,1158,1161,1164,1167,1170,1173,1176,1179,1182,1185,1188,1191,1194,1197,1200,1203,1206,1209,1212,1215,1218,1221,1224,1227,1230,1233,1236,1239,1242,1245,1248,1251,1254,1257,1260,1263,1266,1269,1272,1275,1278,1281,1284,1287,1290,1293,1296,1299,1302,1305,1308,1311,1314,1317,1320,1323,1326,1329,1332,1335,1338,1341,1344,1347,1350,1353,1356,1359,1362,1365,1368,1371,1374,1377,1380,1383,1386,1389,1392,1395,1398,1401,1404,1407,1410,1413,1416,1419,1422,1425,1428,1431,1434,1437,1440,1443,1446,1449],{"id":24,"text":847,"url":24,"identifiers":848},"10.1074\u002Fjbc.m603761200",{"doi":847},{"id":24,"text":850,"url":24,"identifiers":851},"10.1016\u002Fj.bbamem.2006.02.015",{"doi":850},{"id":24,"text":853,"url":24,"identifiers":854},"10.1126\u002Fscience.1130481",{"doi":853},{"id":24,"text":856,"url":24,"identifiers":857},"10.1016\u002Fj.taap.2012.08.005",{"doi":856},{"id":24,"text":859,"url":24,"identifiers":860},"10.1089\u002Fars.2013.5330",{"doi":859},{"id":24,"text":862,"url":24,"identifiers":863},"10.1073\u002Fpnas.1005776107",{"doi":862},{"id":24,"text":865,"url":24,"identifiers":866},"10.1016\u002Fj.molcel.2007.03.016",{"doi":865},{"id":24,"text":868,"url":24,"identifiers":869},"10.1089\u002Fars.2007.1957",{"doi":868},{"id":24,"text":871,"url":24,"identifiers":872},"10.3390\u002Fijms14023568",{"doi":871},{"id":24,"text":874,"url":24,"identifiers":875},"10.1016\u002Fs0027-5107(01)00091-4",{"doi":874},{"id":24,"text":877,"url":24,"identifiers":878},"10.1016\u002F0003-9861(84)90010-9",{"doi":877},{"id":24,"text":880,"url":24,"identifiers":881},"10.1158\u002F0008-5472.can-07-5259",{"doi":880},{"id":24,"text":883,"url":24,"identifiers":884},"10.1126\u002Fscience.1156906",{"doi":883},{"id":24,"text":886,"url":24,"identifiers":887},"10.1007\u002Fs00018-009-0099-y",{"doi":886},{"id":24,"text":889,"url":24,"identifiers":890},"10.1128\u002FMCB.02265-06",{"doi":889},{"id":24,"text":892,"url":24,"identifiers":893},"10.1023\u002Fb:cbto.0000004952.07979.3d",{"doi":892},{"id":24,"text":895,"url":24,"identifiers":896},"10.18632\u002Foncotarget.463",{"doi":895},{"id":24,"text":898,"url":24,"identifiers":899},"10.1155\u002F2013\u002F972913",{"doi":898},{"id":24,"text":901,"url":24,"identifiers":902},"10.1016\u002Fj.ccr.2011.08.024",{"doi":901},{"id":24,"text":904,"url":24,"identifiers":905},"10.1038\u002Fnature10189",{"doi":904},{"id":24,"text":907,"url":24,"identifiers":908},"10.1038\u002Fnrm3801",{"doi":907},{"id":24,"text":910,"url":24,"identifiers":911},"10.2741\u002F1667",{"doi":910},{"id":24,"text":913,"url":24,"identifiers":914},"10.1074\u002Fjbc.m002740200",{"doi":913},{"id":24,"text":916,"url":24,"identifiers":917},"10.1038\u002F20459",{"doi":916},{"id":24,"text":919,"url":24,"identifiers":920},"10.1006\u002Fbbrc.1999.0878",{"doi":919},{"id":24,"text":922,"url":24,"identifiers":923},"10.1128\u002FMCB.18.7.4089",{"doi":922},{"id":24,"text":925,"url":24,"identifiers":926},"10.1038\u002Fsj.cdd.4402307",{"doi":925},{"id":24,"text":928,"url":24,"identifiers":929},"10.1016\u002Fj.semcancer.2013.08.007",{"doi":928},{"id":24,"text":931,"url":24,"identifiers":932},"10.1083\u002Fjcb.200609074",{"doi":931},{"id":24,"text":934,"url":24,"identifiers":935},"10.1074\u002Fjbc.m001914200",{"doi":934},{"id":24,"text":937,"url":24,"identifiers":938},"10.1016\u002Fj.ccr.2007.08.004",{"doi":937},{"id":24,"text":940,"url":24,"identifiers":941},"10.1016\u002Fj.cmet.2005.05.001",{"doi":940},{"id":24,"text":943,"url":24,"identifiers":944},"10.1161\u002F01.ATV.0000258979.92828.bc",{"doi":943},{"id":24,"text":946,"url":24,"identifiers":947},"10.1042\u002FBJ20081386",{"doi":946},{"id":24,"text":949,"url":24,"identifiers":950},"10.3109\u002F10715761003667554",{"doi":949},{"id":24,"text":952,"url":24,"identifiers":953},"10.1016\u002Fj.exger.2010.01.003",{"doi":952},{"id":24,"text":955,"url":24,"identifiers":956},"10.1016\u002Fj.bbamcr.2006.09.006",{"doi":955},{"id":24,"text":958,"url":24,"identifiers":959},"10.1089\u002Fars.2007.1782",{"doi":958},{"id":24,"text":961,"url":24,"identifiers":962},"10.3390\u002Fijms14023683",{"doi":961},{"id":24,"text":964,"url":24,"identifiers":965},"10.1038\u002Fnrc1782",{"doi":964},{"id":24,"text":967,"url":24,"identifiers":968},"10.1097\u002F00062752-199502010-00008",{"doi":967},{"id":24,"text":970,"url":24,"identifiers":971},"Cui S., 1994, Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms, Cancer Research, 54, 2462",{},{"id":24,"text":973,"url":24,"identifiers":974},"10.1038\u002Fnrd2222",{"doi":973},{"id":24,"text":976,"url":24,"identifiers":977},"10.1080\u002F09553009414550041",{"doi":976},{"id":24,"text":979,"url":24,"identifiers":980},"10.1177\u002F0192623309356453",{"doi":979},{"id":24,"text":982,"url":24,"identifiers":983},"10.1038\u002Fnrd4002",{"doi":982},{"id":24,"text":985,"url":24,"identifiers":986},"10.1007\u002Fs13277-013-0804-1",{"doi":985},{"id":24,"text":988,"url":24,"identifiers":989},"10.1016\u002Fj.cbi.2005.12.009",{"doi":988},{"id":24,"text":991,"url":24,"identifiers":992},"10.1002\u002Fcbf.1275",{"doi":991},{"id":24,"text":994,"url":24,"identifiers":995},"10.4161\u002Foxim.3.1.10095",{"doi":994},{"id":24,"text":997,"url":24,"identifiers":998},"10.1080\u002F10408360500523878",{"doi":997},{"id":24,"text":1000,"url":24,"identifiers":1001},"10.1016\u002F0959-8049(96)00051-2",{"doi":1000},{"id":24,"text":1003,"url":24,"identifiers":1004},"10.1016\u002Fs0009-2797(98)00008-8",{"doi":1003},{"id":24,"text":1006,"url":24,"identifiers":1007},"10.1186\u002F1471-2407-9-56",{"doi":1006},{"id":24,"text":1009,"url":24,"identifiers":1010},"10.1016\u002Fj.bbcan.2010.07.004",{"doi":1009},{"id":24,"text":1012,"url":24,"identifiers":1013},"10.3892\u002Fijo.2011.986",{"doi":1012},{"id":24,"text":1015,"url":24,"identifiers":1016},"10.1016\u002Fj.ccell.2014.11.019",{"doi":1015},{"id":24,"text":1018,"url":24,"identifiers":1019},"10.18632\u002Foncotarget.375",{"doi":1018},{"id":24,"text":1021,"url":24,"identifiers":1022},"10.18632\u002Foncoscience.12",{"doi":1021},{"id":24,"text":1024,"url":24,"identifiers":1025},"10.1046\u002Fj.1432-1327.2000.01701.x",{"doi":1024},{"id":24,"text":1027,"url":24,"identifiers":1028},"10.1093\u002Femboj\u002F17.9.2596",{"doi":1027},{"id":24,"text":1030,"url":24,"identifiers":1031},"10.1126\u002Fscience.275.5296.90",{"doi":1030},{"id":24,"text":1033,"url":24,"identifiers":1034},"10.1093\u002Fembo-reports\u002Fkve046",{"doi":1033},{"id":24,"text":1036,"url":24,"identifiers":1037},"10.1016\u002Fs0891-5849(00)00313-0",{"doi":1036},{"id":24,"text":1039,"url":24,"identifiers":1040},"10.1182\u002Fblood.V89.7.2480",{"doi":1039},{"id":24,"text":1042,"url":24,"identifiers":1043},"Kawahara N., 1996, Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin, Cancer Research, 56, 5330",{},{"id":24,"text":1045,"url":24,"identifiers":1046},"Yokomizo A., 1995, Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide, Cancer Research, 55, 4293",{},{"id":24,"text":1048,"url":24,"identifiers":1049},"10.1016\u002Fj.mad.2004.08.012",{"doi":1048},{"id":24,"text":1051,"url":24,"identifiers":1052},"Ho J. C.-M., 2001, Differential expression of manganese superoxide dismutase and catalase in lung cancer, Cancer Research, 61, 8578",{},{"id":24,"text":1054,"url":24,"identifiers":1055},"10.1097\u002F00029330-200712010-00006",{"doi":1054},{"id":24,"text":1057,"url":24,"identifiers":1058},"10.1007\u002Fs005350050181",{"doi":1057},{"id":24,"text":1060,"url":24,"identifiers":1061},"Janssen A. M. L., 2000, Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer, Clinical Cancer Research, 6, 3183",{},{"id":24,"text":1063,"url":24,"identifiers":1064},"Salzman R., 2007, Increased activity of superoxide dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases, Neoplasma, 54, 321",{},{"id":24,"text":1066,"url":24,"identifiers":1067},"10.1006\u002Fjsre.1999.5773",{"doi":1066},{"id":24,"text":1069,"url":24,"identifiers":1070},"10.1016\u002Fj.freeradbiomed.2015.04.001",{"doi":1069},{"id":24,"text":1072,"url":24,"identifiers":1073},"Nelson K. K., 2003, Elevated Sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis, Clinical Cancer Research, 9, 424",{},{"id":24,"text":1075,"url":24,"identifiers":1076},"10.1074\u002Fjbc.M100199200",{"doi":1075},{"id":24,"text":1078,"url":24,"identifiers":1079},"10.1016\u002Fj.febslet.2007.08.021",{"doi":1078},{"id":24,"text":1081,"url":24,"identifiers":1082},"Cullen J. J., 2003, The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma, Cancer Research, 63, 1297",{},{"id":24,"text":1084,"url":24,"identifiers":1085},"10.1074\u002Fjbc.m503296200",{"doi":1084},{"id":24,"text":1087,"url":24,"identifiers":1088},"Oberley L. W., 1979, Role of superoxide dismutase in cancer: a review, Cancer Research, 39, 1141",{},{"id":24,"text":1090,"url":24,"identifiers":1091},"10.1002\u002Fpath.946",{"doi":1090},{"id":24,"text":1093,"url":24,"identifiers":1094},"10.1128\u002FMCB.25.17.7758-7769.2005",{"doi":1093},{"id":24,"text":1096,"url":24,"identifiers":1097},"10.1016\u002Fj.biopha.2005.03.006",{"doi":1096},{"id":24,"text":1099,"url":24,"identifiers":1100},"10.1089\u002F152308604773934260",{"doi":1099},{"id":24,"text":1102,"url":24,"identifiers":1103},"10.1089\u002Fars.2006.8.1283",{"doi":1102},{"id":24,"text":1105,"url":24,"identifiers":1106},"10.1002\u002F(sici)1097-0045(19980515)35:3lt;221::aid-pros8>3.0.co;2-j",{"doi":1105},{"id":24,"text":1108,"url":24,"identifiers":1109},"10.1073\u002Fpnas.68.5.1024",{"doi":1108},{"id":24,"text":1111,"url":24,"identifiers":1112},"10.1042\u002Fbj0600310",{"doi":1111},{"id":24,"text":1114,"url":24,"identifiers":1115},"10.1016\u002F0005-2744(70)90052-5",{"doi":1114},{"id":24,"text":1117,"url":24,"identifiers":1118},"10.1074\u002Fjbc.m503991200",{"doi":1117},{"id":24,"text":1120,"url":24,"identifiers":1121},"10.1016\u002Fj.jinorgbio.2009.07.011",{"doi":1120},{"id":24,"text":1123,"url":24,"identifiers":1124},"10.1515\u002FBC.2010.068",{"doi":1123},{"id":24,"text":1126,"url":24,"identifiers":1127},"10.1016\u002Fs0891-5849(00)00512-8",{"doi":1126},{"id":24,"text":1129,"url":24,"identifiers":1130},"10.1016\u002Fs0891-5849(98)00092-6",{"doi":1129},{"id":24,"text":1132,"url":24,"identifiers":1133},"10.1111\u002Fj.1432-1033.1995.tb20798.x",{"doi":1132},{"id":24,"text":1135,"url":24,"identifiers":1136},"10.1007\u002Fs13277-014-2714-2",{"doi":1135},{"id":24,"text":1138,"url":24,"identifiers":1139},"10.1158\u002F1078-0432.ccr-06-2082",{"doi":1138},{"id":24,"text":1141,"url":24,"identifiers":1142},"10.1097\u002F00008390-199810000-00001",{"doi":1141},{"id":24,"text":1144,"url":24,"identifiers":1145},"10.1002\u002Fijc.22493",{"doi":1144},{"id":24,"text":1147,"url":24,"identifiers":1148},"Bechtel W., 2009, Modulation of intercellular ROS signaling of human tumor cells, Anticancer Research, 29, 4559",{},{"id":24,"text":1150,"url":24,"identifiers":1151},"Bechtel W., 2009, Catalase protects tumor cells from apoptosis induction by intercellular ROS signaling, Anticancer Research, 29, 4541",{},{"id":24,"text":1153,"url":24,"identifiers":1154},"Bauer G., 2000, Reactive oxygen and nitrogen species: efficient, selective, and interactive signals during intercellular induction of apoptosis, Anticancer Research, 20, 4115",{},{"id":24,"text":1156,"url":24,"identifiers":1157},"Bauer G., 2012, Tumor cell-protective catalase as a novel target for rational therapeutic approaches based on specific intercellular ROS signaling, Anticancer Research, 32, 2599",{},{"id":24,"text":1159,"url":24,"identifiers":1160},"10.1515\u002Fhsz-2014-0234",{"doi":1159},{"id":24,"text":1162,"url":24,"identifiers":1163},"10.3892\u002Fijo.2014.2398",{"doi":1162},{"id":24,"text":1165,"url":24,"identifiers":1166},"10.1038\u002Fbjc.2013.396",{"doi":1165},{"id":24,"text":1168,"url":24,"identifiers":1169},"10.1155\u002F2014\u002F715867",{"doi":1168},{"id":24,"text":1171,"url":24,"identifiers":1172},"10.3164\u002Fjcbn.11-109",{"doi":1171},{"id":24,"text":1174,"url":24,"identifiers":1175},"10.1016\u002Fj.fob.2012.12.002",{"doi":1174},{"id":24,"text":1177,"url":24,"identifiers":1178},"10.1111\u002Fj.1440-1843.2006.00849.x",{"doi":1177},{"id":24,"text":1180,"url":24,"identifiers":1181},"10.1002\u002Fpath.1042",{"doi":1180},{"id":24,"text":1183,"url":24,"identifiers":1184},"10.1016\u002Fj.bbapap.2014.11.011",{"doi":1183},{"id":24,"text":1186,"url":24,"identifiers":1187},"10.2147\u002Fbctt.s61281",{"doi":1186},{"id":24,"text":1189,"url":24,"identifiers":1190},"10.1016\u002Fj.mam.2007.04.005",{"doi":1189},{"id":24,"text":1192,"url":24,"identifiers":1193},"10.1074\u002Fjbc.m114.621995",{"doi":1192},{"id":24,"text":1195,"url":24,"identifiers":1196},"10.3892\u002Fijo_00000369",{"doi":1195},{"id":24,"text":1198,"url":24,"identifiers":1199},"10.1074\u002Fjbc.m705929200",{"doi":1198},{"id":24,"text":1201,"url":24,"identifiers":1202},"Wei S. J., 2000, Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation, Cancer Research, 60, 6688",{},{"id":24,"text":1204,"url":24,"identifiers":1205},"10.1021\u002Fjm500865u",{"doi":1204},{"id":24,"text":1207,"url":24,"identifiers":1208},"10.3892\u002Fijo.2014.2589",{"doi":1207},{"id":24,"text":1210,"url":24,"identifiers":1211},"Bobola M. S., 2001, Apurinic\u002Fapyrimidinic endonuclease activity is elevated in human adult gliomas, Clinical Cancer Research, 7, 3510",{},{"id":24,"text":1213,"url":24,"identifiers":1214},"10.1002\u002Fijc.25900",{"doi":1213},{"id":24,"text":1216,"url":24,"identifiers":1217},"10.1111\u002Fj.1751-2980.2010.00442.x",{"doi":1216},{"id":24,"text":1219,"url":24,"identifiers":1220},"10.1016\u002Fj.canlet.2004.11.007",{"doi":1219},{"id":24,"text":1222,"url":24,"identifiers":1223},"10.1089\u002Fars.2008.2226",{"doi":1222},{"id":24,"text":1225,"url":24,"identifiers":1226},"10.1016\u002Fj.freeradbiomed.2013.06.041",{"doi":1225},{"id":24,"text":1228,"url":24,"identifiers":1229},"10.1002\u002Fjcp.20246",{"doi":1228},{"id":24,"text":1231,"url":24,"identifiers":1232},"10.2174\u002F09298673113209990154",{"doi":1231},{"id":24,"text":1234,"url":24,"identifiers":1235},"10.1016\u002Fj.redox.2012.10.001",{"doi":1234},{"id":24,"text":1237,"url":24,"identifiers":1238},"10.1002\u002Fpath.2653",{"doi":1237},{"id":24,"text":1240,"url":24,"identifiers":1241},"10.1073\u002Fpnas.0806268105",{"doi":1240},{"id":24,"text":1243,"url":24,"identifiers":1244},"10.1016\u002Fj.tibs.2008.12.008",{"doi":1243},{"id":24,"text":1246,"url":24,"identifiers":1247},"10.1158\u002F0008-5472.can-05-1997",{"doi":1246},{"id":24,"text":1249,"url":24,"identifiers":1250},"10.1016\u002Fj.freeradbiomed.2011.09.035",{"doi":1249},{"id":24,"text":1252,"url":24,"identifiers":1253},"10.1038\u002Fsj.onc.1207137",{"doi":1252},{"id":24,"text":1255,"url":24,"identifiers":1256},"10.1074\u002Fjbc.m207509200",{"doi":1255},{"id":24,"text":1258,"url":24,"identifiers":1259},"10.1016\u002Fj.cell.2011.07.032",{"doi":1258},{"id":24,"text":1261,"url":24,"identifiers":1262},"10.1189\u002Fjlb.1202629",{"doi":1261},{"id":24,"text":1264,"url":24,"identifiers":1265},"10.1016\u002Fj.canlet.2008.03.035",{"doi":1264},{"id":24,"text":1267,"url":24,"identifiers":1268},"10.1517\u002F14728222.2013.772136",{"doi":1267},{"id":24,"text":1270,"url":24,"identifiers":1271},"10.1038\u002Fsj.onc.1203159",{"doi":1270},{"id":24,"text":1273,"url":24,"identifiers":1274},"10.1002\u002Fijc.23754",{"doi":1273},{"id":24,"text":1276,"url":24,"identifiers":1277},"10.1016\u002Fj.freeradbiomed.2011.05.018",{"doi":1276},{"id":24,"text":1279,"url":24,"identifiers":1280},"10.1126\u002Fscitranslmed.3007653",{"doi":1279},{"id":24,"text":1282,"url":24,"identifiers":1283},"10.1126\u002Fscitranslmed.3008488",{"doi":1282},{"id":24,"text":1285,"url":24,"identifiers":1286},"10.1126\u002Fscitranslmed.3007154",{"doi":1285},{"id":24,"text":1288,"url":24,"identifiers":1289},"10.1007\u002Fs12094-013-1028-y",{"doi":1288},{"id":24,"text":1291,"url":24,"identifiers":1292},"10.3892\u002For.2015.3837",{"doi":1291},{"id":24,"text":1294,"url":24,"identifiers":1295},"10.4149\u002Fneo_2014_078",{"doi":1294},{"id":24,"text":1297,"url":24,"identifiers":1298},"10.1182\u002Fblood-2011-06-334672",{"doi":1297},{"id":24,"text":1300,"url":24,"identifiers":1301},"10.1667\u002Frr3056.1",{"doi":1300},{"id":24,"text":1303,"url":24,"identifiers":1304},"10.1371\u002Fjournal.pone.0050591",{"doi":1303},{"id":24,"text":1306,"url":24,"identifiers":1307},"10.1073\u002Fpnas.0402959101",{"doi":1306},{"id":24,"text":1309,"url":24,"identifiers":1310},"10.1016\u002Fj.bbrc.2004.03.110",{"doi":1309},{"id":24,"text":1312,"url":24,"identifiers":1313},"10.1016\u002Fj.neures.2010.04.002",{"doi":1312},{"id":24,"text":1315,"url":24,"identifiers":1316},"10.3892\u002Fijo-00000451",{"doi":1315},{"id":24,"text":1318,"url":24,"identifiers":1319},"10.1371\u002Fjournal.pbio.0020362",{"doi":1318},{"id":24,"text":1321,"url":24,"identifiers":1322},"10.1074\u002Fjbc.m507124200",{"doi":1321},{"id":24,"text":1324,"url":24,"identifiers":1325},"10.1074\u002Fjbc.m806902200",{"doi":1324},{"id":24,"text":1327,"url":24,"identifiers":1328},"10.1073\u002Fpnas.0607260103",{"doi":1327},{"id":24,"text":1330,"url":24,"identifiers":1331},"10.1002\u002Fcbf.2949",{"doi":1330},{"id":24,"text":1333,"url":24,"identifiers":1334},"10.18632\u002Foncotarget.3841",{"doi":1333},{"id":24,"text":1336,"url":24,"identifiers":1337},"10.1002\u002Fjcp.24957",{"doi":1336},{"id":24,"text":1339,"url":24,"identifiers":1340},"10.1016\u002Fj.freeradbiomed.2014.03.026",{"doi":1339},{"id":24,"text":1342,"url":24,"identifiers":1343},"10.1016\u002Fj.phytochem.2014.09.001",{"doi":1342},{"id":24,"text":1345,"url":24,"identifiers":1346},"10.1146\u002Fannurev.pharmtox.44.101802.121851",{"doi":1345},{"id":24,"text":1348,"url":24,"identifiers":1349},"10.1016\u002Fj.bbagen.2014.10.008",{"doi":1348},{"id":24,"text":1351,"url":24,"identifiers":1352},"10.1016\u002Fj.tiv.2011.05.006",{"doi":1351},{"id":24,"text":1354,"url":24,"identifiers":1355},"10.1016\u002Fj.ejmech.2013.12.015",{"doi":1354},{"id":24,"text":1357,"url":24,"identifiers":1358},"10.1038\u002Fonc.2009.47",{"doi":1357},{"id":24,"text":1360,"url":24,"identifiers":1361},"10.1042\u002Fbj20021469",{"doi":1360},{"id":24,"text":1363,"url":24,"identifiers":1364},"10.3892\u002For_00000392",{"doi":1363},{"id":24,"text":1366,"url":24,"identifiers":1367},"10.1016\u002Fj.febslet.2010.05.054",{"doi":1366},{"id":24,"text":1369,"url":24,"identifiers":1370},"10.1016\u002Fj.lfs.2013.12.009",{"doi":1369},{"id":24,"text":1372,"url":24,"identifiers":1373},"10.1007\u002Fs12079-007-0006-y",{"doi":1372},{"id":24,"text":1375,"url":24,"identifiers":1376},"10.1002\u002Fijc.21685",{"doi":1375},{"id":24,"text":1378,"url":24,"identifiers":1379},"10.1158\u002F0008-5472.can-06-3914",{"doi":1378},{"id":24,"text":1381,"url":24,"identifiers":1382},"10.1016\u002Fj.toxlet.2012.02.020",{"doi":1381},{"id":24,"text":1384,"url":24,"identifiers":1385},"10.1159\u002F000373938",{"doi":1384},{"id":24,"text":1387,"url":24,"identifiers":1388},"10.1371\u002Fjournal.pone.0070956",{"doi":1387},{"id":24,"text":1390,"url":24,"identifiers":1391},"10.1016\u002Fj.bbabio.2015.02.012",{"doi":1390},{"id":24,"text":1393,"url":24,"identifiers":1394},"10.1016\u002Fj.freeradbiomed.2007.03.020",{"doi":1393},{"id":24,"text":1396,"url":24,"identifiers":1397},"10.1038\u002Fsj.onc.1206940",{"doi":1396},{"id":24,"text":1399,"url":24,"identifiers":1400},"10.1021\u002Fbi00607a008",{"doi":1399},{"id":24,"text":1402,"url":24,"identifiers":1403},"10.7164\u002Fantibiotics.33.426",{"doi":1402},{"id":24,"text":1405,"url":24,"identifiers":1406},"10.3109\u002F10715762.2013.819974",{"doi":1405},{"id":24,"text":1408,"url":24,"identifiers":1409},"10.1007\u002Fs10495-007-0082-8",{"doi":1408},{"id":24,"text":1411,"url":24,"identifiers":1412},"10.1016\u002Fj.bbrc.2006.06.140",{"doi":1411},{"id":24,"text":1414,"url":24,"identifiers":1415},"10.1242\u002Fjcs.092098",{"doi":1414},{"id":24,"text":1417,"url":24,"identifiers":1418},"10.1002\u002Fjcp.20638",{"doi":1417},{"id":24,"text":1420,"url":24,"identifiers":1421},"10.1073\u002Fpnas.1404182111",{"doi":1420},{"id":24,"text":1423,"url":24,"identifiers":1424},"10.1124\u002Fpr.56.2.6",{"doi":1423},{"id":24,"text":1426,"url":24,"identifiers":1427},"10.1096\u002Ffasebj.4.13.2210154",{"doi":1426},{"id":24,"text":1429,"url":24,"identifiers":1430},"10.1016\u002Fj.yjmcc.2006.06.009",{"doi":1429},{"id":24,"text":1432,"url":24,"identifiers":1433},"10.1016\u002Fj.bbabio.2012.09.016",{"doi":1432},{"id":24,"text":1435,"url":24,"identifiers":1436},"10.1007\u002Fs00280-015-2739-2",{"doi":1435},{"id":24,"text":1438,"url":24,"identifiers":1439},"10.1074\u002Fjbc.m113.484576",{"doi":1438},{"id":24,"text":1441,"url":24,"identifiers":1442},"10.1016\u002Fj.bbamcr.2007.05.002",{"doi":1441},{"id":24,"text":1444,"url":24,"identifiers":1445},"10.1007\u002Fs11515-012-1204-4",{"doi":1444},{"id":24,"text":1447,"url":24,"identifiers":1448},"10.1016\u002Fj.tiv.2013.11.006",{"doi":1447},{"id":24,"text":1450,"url":24,"identifiers":1451},"10.3892\u002Fetm.2011.304",{"doi":1450},{"id":1453,"createTime":1454,"updateTime":1454,"relativeEntities":1455,"slug":1456,"properties":1457,"entityType":120,"verifyStatus":121,"verifyTime":1473,"verifyNote":122,"syncStatus":23,"languages":1474,"translateLanguages":24,"viewCount":25,"primaryUrl":1475,"fullTextUrl":24,"authors":1476,"publicationType":220,"publisherRelationship":1680,"citationCount":1704,"citationInfo":1705,"publishDate":1712,"publishYear":1713,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1714,"isForceReanalyzing":395},"20dde5cf-6c55-4484-a2b9-71878ea9e289","2024-09-21T22:32:19.981+00:00",[],"Unraveling-the-Potential-Role-of-Glutathione-in-Multiple-Forms-of-Cell-Death-in-Cancer-Therapy",{"mag":1458,"keywords":1460,"pmc":1461,"openalex":1463,"abstract":1465,"title":1467,"pm":1469,"doi":1471},{"VOID":1459},"2949432489",{},{"VOID":1462},"6590529",{"VOID":1464},"W2949432489",{"EN":1466},"\u003Cjats:p>Glutathione is the principal intracellular antioxidant buffer against oxidative stress and mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG). The processes of glutathione synthesis, transport, utilization, and metabolism are tightly controlled to maintain intracellular glutathione homeostasis and redox balance. As for cancer cells, they exhibit a greater ROS level than normal cells in order to meet the enhanced metabolism and vicious proliferation; meanwhile, they also have to develop an increased antioxidant defense system to cope with the higher oxidant state. Growing numbers of studies have implicated that altering the glutathione antioxidant system is associated with multiple forms of programmed cell death in cancer cells. In this review, we firstly focus on glutathione homeostasis from the perspectives of glutathione synthesis, distribution, transportation, and metabolism. Then, we discuss the function of glutathione in the antioxidant process. Afterwards, we also summarize the recent advance in the understanding of the mechanism by which glutathione plays a key role in multiple forms of programmed cell death, including apoptosis, necroptosis, ferroptosis, and autophagy. Finally, we highlight the glutathione-targeting therapeutic approaches toward cancers. A comprehensive review on the glutathione homeostasis and the role of glutathione depletion in programmed cell death provide insight into the redox-based research concerning cancer therapeutics.\u003C\u002Fjats:p>",{"EN":1468},"Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy",{"VOID":1470},"31281572",{"VOID":1472},"10.1155\u002F2019\u002F3150145","2024-09-21T22:32:19.980+00:00",[124],"https:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fomcl\u002F2019\u002F3150145\u002F",[1477,1518,1538,1571,1616,1651],{"id":1478,"sortIndex":169,"researcher":24,"roles":1479,"affiliations":1480,"properties":1513},"4d501c85-50eb-440c-958d-63cb195e6cf2",[],[1481,1491,1502],{"id":1482,"sortIndex":169,"affiliation":1483,"properties":24},"1a8d0c9e-22ab-4aff-8705-4c62a696eb52",{"id":1484,"createTime":1485,"updateTime":1485,"relativeEntities":1486,"slug":1487,"properties":1488,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"3a906f5c-8f95-4916-8ff2-77cb73b8a8da","2024-09-21T22:32:20.032+00:00",[],"Research-Development-Institute-of-Northwestern-Polytechnical-University-in-Shenzhen-Shenzhen-518057",{"title":1489},{"EN":1490},"Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057",{"id":1492,"sortIndex":151,"affiliation":1493,"properties":24},"bd50b207-f4af-461a-be76-d65f0673ff52",{"id":1494,"createTime":1495,"updateTime":1496,"relativeEntities":1497,"slug":1498,"properties":1499,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b3350749-2653-4469-87ef-528fee9ecd51","2024-01-11T01:58:04.049+00:00","2024-10-16T22:51:57.445+00:00",[],"Research-Development-Institute-of-Northwestern-Polytechnical-University-in-Shenzhen-Shenzhen-518057-China",{"title":1500},{"VI":1501},"Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China",{"id":1503,"sortIndex":25,"affiliation":1504,"properties":24},"451f9b3d-1448-4e01-8a40-9f4289b2f8ed",{"id":1505,"createTime":1506,"updateTime":1507,"relativeEntities":1508,"slug":1509,"properties":1510,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"f295f4ad-a0c1-44bc-9aea-4cb39943e5c1","2024-01-04T18:14:13.635+00:00","2024-09-21T22:32:20.004+00:00",[],"Key-Laboratory-for-Space-Bioscience-and-Biotechnology-Northwestern-Polytechnical-University-Xi-an-Shaanxi-710072-China",{"title":1511},{"VI":1512},"Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China",{"openalex":1514,"title":1516},{"VOID":1515},"A5047009179",{"EN":1517},"Chenxiao Zhen",{"id":1519,"sortIndex":204,"researcher":24,"roles":1520,"affiliations":1521,"properties":1533},"9675a2e4-d479-4a9e-a68e-b46bf1df92e0",[],[1522],{"id":1523,"sortIndex":25,"affiliation":1524,"properties":24},"90fde138-d792-4737-a0f9-a15beb90b116",{"id":1525,"createTime":1526,"updateTime":1527,"relativeEntities":1528,"slug":1529,"properties":1530,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"95dd1747-7350-4b43-9965-4c4ef9d093a6","2024-02-07T20:07:59.445+00:00","2024-09-21T22:32:20.020+00:00",[],"Zhejiang-Heye-Health-Technology-Co-Ltd-Anji-Zhejiang-313300-China",{"title":1531},{"VI":1532},"Zhejiang Heye Health Technology Co., Ltd, Anji, Zhejiang, 313300, China",{"openalex":1534,"title":1536},{"VOID":1535},"A5055178583",{"EN":1537},"Lijiang Hu",{"id":1539,"sortIndex":469,"researcher":24,"roles":1540,"affiliations":1541,"properties":1564},"047f734d-74a1-4383-ae46-4efa0b47e1a5",[],[1542,1548,1554],{"id":1543,"sortIndex":25,"affiliation":1544,"properties":24},"9006be47-f22f-454b-bad6-0eabad738807",{"id":1505,"createTime":1506,"updateTime":1507,"relativeEntities":1545,"slug":1509,"properties":1546,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1547},{"VI":1512},{"id":1549,"sortIndex":169,"affiliation":1550,"properties":24},"77c3cb1e-6487-4dc7-842e-1091d9801096",{"id":1494,"createTime":1495,"updateTime":1496,"relativeEntities":1551,"slug":1498,"properties":1552,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1553},{"VI":1501},{"id":1555,"sortIndex":151,"affiliation":1556,"properties":24},"2d92c357-40ec-402c-893d-2e02644d0c5e",{"id":1557,"createTime":1558,"updateTime":1558,"relativeEntities":1559,"slug":1560,"properties":1561,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"daa433b6-b7cb-4090-83ee-6e49f18cb21a","2024-09-21T22:32:20.015+00:00",[],"Research-Centre-of-Microfluidic-Chip-for-Health-Care-and-Environmental-Monitoring-Yangtze-River-Delta-Research-Institute-of-Northwestern-Polytechnical-University-in-Taicang-Suzhou-Jiangsu-215400-China",{"title":1562},{"EN":1563},"Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400, China",{"openalex":1565,"orcid":1567,"title":1569},{"VOID":1566},"A5078166119",{"VOID":1568},"https:\u002F\u002Forcid.org\u002F0000-0001-5418-6240",{"EN":1570},"Peng Shang",{"id":1572,"sortIndex":25,"researcher":24,"roles":1573,"affiliations":1574,"properties":1609},"74b0a47c-5688-4574-b284-809d00a7c386",[],[1575,1581,1591,1597,1603],{"id":1576,"sortIndex":129,"affiliation":1577,"properties":24},"6a23bfc4-b5b6-4fdd-b63d-03c89ef1bbbe",{"id":1557,"createTime":1558,"updateTime":1558,"relativeEntities":1578,"slug":1560,"properties":1579,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1580},{"EN":1563},{"id":1582,"sortIndex":151,"affiliation":1583,"properties":24},"aff6be70-1542-40e2-ad5c-d2b6e890ed56",{"id":1584,"createTime":1585,"updateTime":1585,"relativeEntities":1586,"slug":1587,"properties":1588,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"fafe0001-7a9b-430d-ba93-572666c0c307","2024-09-21T22:32:20.010+00:00",[],"Research-Centre-of-Microfluidic-Chip-for-Health-Care-and-Environmental-Monitoring-Yangtze-River-Delta-Research-Institute-of-Northwestern-Polytechnical-University-in-Taicang-Suzhou-Jiangsu-215400",{"title":1589},{"EN":1590},"Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400",{"id":1592,"sortIndex":169,"affiliation":1593,"properties":24},"a2b4f3a9-c77b-43fc-8e36-7739e4d6a543",{"id":1494,"createTime":1495,"updateTime":1496,"relativeEntities":1594,"slug":1498,"properties":1595,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1596},{"VI":1501},{"id":1598,"sortIndex":25,"affiliation":1599,"properties":24},"9660e231-6a85-4588-9a4d-397561de257e",{"id":1505,"createTime":1506,"updateTime":1507,"relativeEntities":1600,"slug":1509,"properties":1601,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1602},{"VI":1512},{"id":1604,"sortIndex":204,"affiliation":1605,"properties":24},"a8b95109-6b96-4be2-986e-3c8e24ed0a65",{"id":1525,"createTime":1526,"updateTime":1527,"relativeEntities":1606,"slug":1529,"properties":1607,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1608},{"VI":1532},{"openalex":1610,"orcid":1612,"title":1614},{"VOID":1611},"A5042843937",{"VOID":1613},"https:\u002F\u002Forcid.org\u002F0000-0002-4869-4908",{"EN":1615},"Huanhuan Lv",{"id":1617,"sortIndex":129,"researcher":24,"roles":1618,"affiliations":1619,"properties":1644},"181a84b5-d89a-4aca-a513-021a5a117eb6",[],[1620,1626,1632,1638],{"id":1621,"sortIndex":129,"affiliation":1622,"properties":24},"c1a43b39-51e1-45f0-b742-252e3729038b",{"id":1557,"createTime":1558,"updateTime":1558,"relativeEntities":1623,"slug":1560,"properties":1624,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1625},{"EN":1563},{"id":1627,"sortIndex":151,"affiliation":1628,"properties":24},"9c1d6b52-7731-4dbe-b544-3eaeb2a8f5b8",{"id":1584,"createTime":1585,"updateTime":1585,"relativeEntities":1629,"slug":1587,"properties":1630,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1631},{"EN":1590},{"id":1633,"sortIndex":169,"affiliation":1634,"properties":24},"a22f9b2d-e4a4-42ad-809b-336dc84e4864",{"id":1494,"createTime":1495,"updateTime":1496,"relativeEntities":1635,"slug":1498,"properties":1636,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1637},{"VI":1501},{"id":1639,"sortIndex":25,"affiliation":1640,"properties":24},"f038b9dc-1463-46ab-ab89-7184d406a433",{"id":1505,"createTime":1506,"updateTime":1507,"relativeEntities":1641,"slug":1509,"properties":1642,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1643},{"VI":1512},{"openalex":1645,"orcid":1647,"title":1649},{"VOID":1646},"A5008568732",{"VOID":1648},"https:\u002F\u002Forcid.org\u002F0000-0003-3681-763X",{"EN":1650},"Pengfei Yang",{"id":1652,"sortIndex":151,"researcher":24,"roles":1653,"affiliations":1654,"properties":1673},"d8f70aac-1521-4f69-911e-82b09eadbbe8",[],[1655,1661,1667],{"id":1656,"sortIndex":151,"affiliation":1657,"properties":24},"1bc5a9aa-bf3f-423f-ae0f-52dbffa02be5",{"id":1494,"createTime":1495,"updateTime":1496,"relativeEntities":1658,"slug":1498,"properties":1659,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1660},{"VI":1501},{"id":1662,"sortIndex":25,"affiliation":1663,"properties":24},"18e835a9-c3db-4efa-b0d1-b6ab56c25749",{"id":1505,"createTime":1506,"updateTime":1507,"relativeEntities":1664,"slug":1509,"properties":1665,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1666},{"VI":1512},{"id":1668,"sortIndex":169,"affiliation":1669,"properties":24},"c5996ae6-e7a1-4eba-a0b7-649ddcba4f52",{"id":1484,"createTime":1485,"updateTime":1485,"relativeEntities":1670,"slug":1487,"properties":1671,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1672},{"EN":1490},{"openalex":1674,"orcid":1676,"title":1678},{"VOID":1675},"A5100682740",{"VOID":1677},"https:\u002F\u002Forcid.org\u002F0000-0002-8926-0161",{"EN":1679},"Junyu Liu",{"url":24,"publisher":1681,"properties":1699},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1682,"slug":10,"properties":1683,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1689,"manageAffiliations":1690,"indexDatabases":1691,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1684,"issn":1685,"introduce":1686,"eissn":1687,"title":1688},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1692],{"id":73,"indexDatabase":1693,"url":86,"indexYears":87,"academicFieldIds":1698,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":1694,"label":1695,"description":1696,"key":83,"publicationTags":1697,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":1700,"pages":1702},{"VOID":1701},"2019",{"VOID":1703},"1-16",235,{"total":1704,"publishYear":24,"statisticByYear":1706},{"2018":169,"2019":204,"2020":1707,"2021":1708,"2022":1709,"2023":1710,"2024":1711},30,45,41,60,52,"2019-06-10",2019,[1715,1718,1721,1724,1727,1730,1733,1735,1738,1741,1744,1747,1750,1753,1756,1759,1762,1766,1769,1772,1775,1778,1781,1784,1787,1790,1793,1796,1799,1802,1805,1808,1811,1814,1817,1820,1823,1826,1829,1832,1835,1838,1841,1844,1847,1850,1853,1857,1860,1863,1866,1869,1872,1875,1878,1881,1883,1886,1888,1891,1894,1897,1900,1903,1906,1909,1912,1915,1918,1921,1924,1927,1929,1932,1935,1938,1941,1944,1947,1950,1953,1956,1959,1962,1965,1968,1971,1974,1977,1980,1983,1986,1989,1992,1995,1998,2001,2004,2007,2010,2013,2016,2019,2022,2025,2028,2031,2034,2037,2040,2043,2046,2049,2052,2055,2058,2061,2064,2067,2070,2073,2076,2079,2082,2085,2088,2091,2094,2097,2100,2103,2106,2109,2112,2115,2118,2121,2124,2127,2130,2133,2136,2139,2142,2145,2148,2151,2154,2157,2160,2163,2166,2169,2172,2175,2178,2181,2184,2187,2190,2193,2196,2199,2202],{"id":24,"text":1716,"url":24,"identifiers":1717},"10.1146\u002Fannurev.bi.52.070183.003431",{"doi":1716},{"id":24,"text":1719,"url":24,"identifiers":1720},"10.1093\u002Fjn\u002F134.3.489",{"doi":1719},{"id":24,"text":1722,"url":24,"identifiers":1723},"10.1016\u002FS0891-5849(99)00177-X",{"doi":1722},{"id":24,"text":1725,"url":24,"identifiers":1726},"10.1016\u002Fj.semcdb.2017.05.023",{"doi":1725},{"id":24,"text":1728,"url":24,"identifiers":1729},"10.1016\u002Fj.freeradbiomed.2017.01.004",{"doi":1728},{"id":24,"text":1731,"url":24,"identifiers":1732},"10.1016\u002Fj.freeradbiomed.2009.12.022",{"doi":1731},{"id":24,"text":898,"url":24,"identifiers":1734},{"doi":898},{"id":24,"text":1736,"url":24,"identifiers":1737},"10.1016\u002Fj.ccell.2015.01.007",{"doi":1736},{"id":24,"text":1739,"url":24,"identifiers":1740},"10.1089\u002Fars.2017.7134",{"doi":1739},{"id":24,"text":1742,"url":24,"identifiers":1743},"10.1016\u002FS0009-2797(97)00146-4",{"doi":1742},{"id":24,"text":1745,"url":24,"identifiers":1746},"10.1016\u002Fj.freeradbiomed.2004.06.040",{"doi":1745},{"id":24,"text":1748,"url":24,"identifiers":1749},"10.1016\u002Fj.bbagen.2012.09.008",{"doi":1748},{"id":24,"text":1751,"url":24,"identifiers":1752},"10.1042\u002Fbj20100409",{"doi":1751},{"id":24,"text":1754,"url":24,"identifiers":1755},"10.1042\u002Fbj2940631",{"doi":1754},{"id":24,"text":1757,"url":24,"identifiers":1758},"2003, Journal of Biological Chemistry, 281, 6372",{},{"id":24,"text":1760,"url":24,"identifiers":1761},"10.1016\u002Fj.freeradbiomed.2015.09.023",{"doi":1760},{"id":24,"text":1763,"url":24,"identifiers":1764},"1982, The Journal of Biological Chemistry, 257, 3747, 10.1016\u002FS0021-9258(18)34844-0",{"doi":1765},"10.1016\u002FS0021-9258(18)34844-0",{"id":24,"text":1767,"url":24,"identifiers":1768},"10.1126\u002Fscience.1523409",{"doi":1767},{"id":24,"text":1770,"url":24,"identifiers":1771},"10.1038\u002Fnchembio.1142",{"doi":1770},{"id":24,"text":1773,"url":24,"identifiers":1774},"10.1016\u002Fj.mam.2008.05.005",{"doi":1773},{"id":24,"text":1776,"url":24,"identifiers":1777},"10.1042\u002FBST20140101",{"doi":1776},{"id":24,"text":1779,"url":24,"identifiers":1780},"10.1111\u002Fj.1365-313X.2007.03280.x",{"doi":1779},{"id":24,"text":1782,"url":24,"identifiers":1783},"10.1089\u002Fars.2017.7121",{"doi":1782},{"id":24,"text":1785,"url":24,"identifiers":1786},"10.1089\u002Fars.2009.2695",{"doi":1785},{"id":24,"text":1788,"url":24,"identifiers":1789},"10.1016\u002FS0300-483X(98)00093-6",{"doi":1788},{"id":24,"text":1791,"url":24,"identifiers":1792},"10.1038\u002Fki.1988.169",{"doi":1791},{"id":24,"text":1794,"url":24,"identifiers":1795},"10.1038\u002Femboj.2012.165",{"doi":1794},{"id":24,"text":1797,"url":24,"identifiers":1798},"10.1016\u002Fj.ceb.2009.04.002",{"doi":1797},{"id":24,"text":1800,"url":24,"identifiers":1801},"10.1016\u002Fj.tcb.2013.07.011",{"doi":1800},{"id":24,"text":1803,"url":24,"identifiers":1804},"10.1016\u002Fj.tibs.2016.01.001",{"doi":1803},{"id":24,"text":1806,"url":24,"identifiers":1807},"10.1016\u002Fj.taap.2004.10.004",{"doi":1806},{"id":24,"text":1809,"url":24,"identifiers":1810},"10.1016\u002Fj.cbi.2006.03.001",{"doi":1809},{"id":24,"text":1812,"url":24,"identifiers":1813},"10.1006\u002Fabbi.1999.1527",{"doi":1812},{"id":24,"text":1815,"url":24,"identifiers":1816},"10.1074\u002Fjbc.M609582200",{"doi":1815},{"id":24,"text":1818,"url":24,"identifiers":1819},"10.1111\u002Fj.1365-313X.2010.04371.x",{"doi":1818},{"id":24,"text":1821,"url":24,"identifiers":1822},"10.1073\u002Fpnas.73.7.2275",{"doi":1821},{"id":24,"text":1824,"url":24,"identifiers":1825},"10.1016\u002Fj.biocel.2006.07.001",{"doi":1824},{"id":24,"text":1827,"url":24,"identifiers":1828},"10.1042\u002Fbst0050611",{"doi":1827},{"id":24,"text":1830,"url":24,"identifiers":1831},"10.1038\u002Fnature17041",{"doi":1830},{"id":24,"text":1833,"url":24,"identifiers":1834},"10.1016\u002Fj.redox.2013.10.005",{"doi":1833},{"id":24,"text":1836,"url":24,"identifiers":1837},"10.1089\u002Fars.2014.5851",{"doi":1836},{"id":24,"text":1839,"url":24,"identifiers":1840},"10.1016\u002F0006-291X(80)91433-3",{"doi":1839},{"id":24,"text":1842,"url":24,"identifiers":1843},"10.1016\u002F0014-5793(79)80558-X",{"doi":1842},{"id":24,"text":1845,"url":24,"identifiers":1846},"10.1016\u002F0304-4165(78)90037-5",{"doi":1845},{"id":24,"text":1848,"url":24,"identifiers":1849},"10.1016\u002FS0006-2952(99)00155-0",{"doi":1848},{"id":24,"text":1851,"url":24,"identifiers":1852},"10.1172\u002FJCI5392",{"doi":1851},{"id":24,"text":1854,"url":24,"identifiers":1855},"1985, Journal of Biological Chemistry, 260, 326, 10.1016\u002FS0021-9258(18)89735-6",{"doi":1856},"10.1016\u002FS0021-9258(18)89735-6",{"id":24,"text":1858,"url":24,"identifiers":1859},"10.1016\u002Fj.taap.2004.09.008",{"doi":1858},{"id":24,"text":1861,"url":24,"identifiers":1862},"10.1074\u002Fjbc.273.26.16184",{"doi":1861},{"id":24,"text":1864,"url":24,"identifiers":1865},"10.1016\u002Fj.bbagen.2012.11.018",{"doi":1864},{"id":24,"text":1867,"url":24,"identifiers":1868},"10.1016\u002Fb978-0-12-420117-0.00003-7",{"doi":1867},{"id":24,"text":1870,"url":24,"identifiers":1871},"10.1042\u002FBJ20141154",{"doi":1870},{"id":24,"text":1873,"url":24,"identifiers":1874},"10.1038\u002Fembor.2012.156",{"doi":1873},{"id":24,"text":1876,"url":24,"identifiers":1877},"10.1074\u002Fjbc.M803623200",{"doi":1876},{"id":24,"text":1879,"url":24,"identifiers":1880},"10.1074\u002Fjbc.M116.727479",{"doi":1879},{"id":24,"text":982,"url":24,"identifiers":1882},{"doi":982},{"id":24,"text":1884,"url":24,"identifiers":1885},"10.3390\u002Fcancers3011285",{"doi":1884},{"id":24,"text":946,"url":24,"identifiers":1887},{"doi":946},{"id":24,"text":1889,"url":24,"identifiers":1890},"10.1111\u002Fj.1365-2184.2012.00845.x",{"doi":1889},{"id":24,"text":1892,"url":24,"identifiers":1893},"10.1186\u002Fs12943-015-0321-5",{"doi":1892},{"id":24,"text":1895,"url":24,"identifiers":1896},"2012, Toxicologic Pathology, 29, 997",{},{"id":24,"text":1898,"url":24,"identifiers":1899},"10.1016\u002Fj.ejphar.2012.05.003",{"doi":1898},{"id":24,"text":1901,"url":24,"identifiers":1902},"10.1074\u002Fjbc.M703091200",{"doi":1901},{"id":24,"text":1904,"url":24,"identifiers":1905},"10.1002\u002Fiub.1068",{"doi":1904},{"id":24,"text":1907,"url":24,"identifiers":1908},"10.1038\u002Fsj.cdd.4400959",{"doi":1907},{"id":24,"text":1910,"url":24,"identifiers":1911},"10.1096\u002Ffasebj.12.6.479",{"doi":1910},{"id":24,"text":1913,"url":24,"identifiers":1914},"10.1074\u002Fjbc.M611019200",{"doi":1913},{"id":24,"text":1916,"url":24,"identifiers":1917},"10.1016\u002Fj.jnutbio.2011.05.006",{"doi":1916},{"id":24,"text":1919,"url":24,"identifiers":1920},"10.1016\u002Fj.tiv.2016.12.012",{"doi":1919},{"id":24,"text":1922,"url":24,"identifiers":1923},"10.1089\u002Fars.2011.4170",{"doi":1922},{"id":24,"text":1925,"url":24,"identifiers":1926},"10.1080\u002F10715760802317663",{"doi":1925},{"id":24,"text":389,"url":24,"identifiers":1928},{"doi":389},{"id":24,"text":1930,"url":24,"identifiers":1931},"10.1038\u002Fsj.cgt.7700684",{"doi":1930},{"id":24,"text":1933,"url":24,"identifiers":1934},"10.1038\u002Fnrm2970",{"doi":1933},{"id":24,"text":1936,"url":24,"identifiers":1937},"10.1038\u002Fnrm3737",{"doi":1936},{"id":24,"text":1939,"url":24,"identifiers":1940},"10.1016\u002Fj.ceb.2009.12.003",{"doi":1939},{"id":24,"text":1942,"url":24,"identifiers":1943},"10.1016\u002Fj.cell.2008.12.004",{"doi":1942},{"id":24,"text":1945,"url":24,"identifiers":1946},"10.1053\u002Fjhep.2002.33995",{"doi":1945},{"id":24,"text":1948,"url":24,"identifiers":1949},"10.1111\u002Fj.1471-4159.2007.04884.x",{"doi":1948},{"id":24,"text":1951,"url":24,"identifiers":1952},"10.1007\u002Fs11010-017-3052-7",{"doi":1951},{"id":24,"text":1954,"url":24,"identifiers":1955},"10.1111\u002Fbph.13184",{"doi":1954},{"id":24,"text":1957,"url":24,"identifiers":1958},"10.18632\u002Foncotarget.23055",{"doi":1957},{"id":24,"text":1960,"url":24,"identifiers":1961},"10.1016\u002Fj.cell.2012.03.042",{"doi":1960},{"id":24,"text":1963,"url":24,"identifiers":1964},"10.1016\u002Fj.cell.2012.05.009",{"doi":1963},{"id":24,"text":1966,"url":24,"identifiers":1967},"10.1016\u002Fj.tcb.2015.10.014",{"doi":1966},{"id":24,"text":1969,"url":24,"identifiers":1970},"10.1038\u002Fsrep30033",{"doi":1969},{"id":24,"text":1972,"url":24,"identifiers":1973},"10.1016\u002Fj.molcel.2015.06.011",{"doi":1972},{"id":24,"text":1975,"url":24,"identifiers":1976},"10.3389\u002Ffphar.2018.01371",{"doi":1975},{"id":24,"text":1978,"url":24,"identifiers":1979},"10.1038\u002Fncb3064",{"doi":1978},{"id":24,"text":1981,"url":24,"identifiers":1982},"10.1016\u002Fj.freeradbiomed.2018.09.014",{"doi":1981},{"id":24,"text":1984,"url":24,"identifiers":1985},"10.1016\u002Fj.freeradbiomed.2018.09.043",{"doi":1984},{"id":24,"text":1987,"url":24,"identifiers":1988},"10.1016\u002Fj.chembiol.2008.02.010",{"doi":1987},{"id":24,"text":1990,"url":24,"identifiers":1991},"10.1016\u002Fj.cell.2013.12.010",{"doi":1990},{"id":24,"text":1993,"url":24,"identifiers":1994},"10.1038\u002Fnchembio.2079",{"doi":1993},{"id":24,"text":1996,"url":24,"identifiers":1997},"10.1038\u002Fs41388-018-0315-z",{"doi":1996},{"id":24,"text":1999,"url":24,"identifiers":2000},"10.1038\u002Fnchembio.2261",{"doi":1999},{"id":24,"text":2002,"url":24,"identifiers":2003},"10.1016\u002Fj.freeradbiomed.2018.09.008",{"doi":2002},{"id":24,"text":2005,"url":24,"identifiers":2006},"10.1038\u002Fnchembio.2238",{"doi":2005},{"id":24,"text":2008,"url":24,"identifiers":2009},"10.1016\u002Fj.tips.2017.02.005",{"doi":2008},{"id":24,"text":2011,"url":24,"identifiers":2012},"10.1002\u002Fijc.28159",{"doi":2011},{"id":24,"text":2014,"url":24,"identifiers":2015},"10.1016\u002Fj.canlet.2014.11.014",{"doi":2014},{"id":24,"text":2017,"url":24,"identifiers":2018},"10.1158\u002F0008-5472.CAN-09-4027",{"doi":2017},{"id":24,"text":2020,"url":24,"identifiers":2021},"10.1016\u002Fj.cell.2014.02.049",{"doi":2020},{"id":24,"text":2023,"url":24,"identifiers":2024},"10.1038\u002Fcdd.2014.150",{"doi":2023},{"id":24,"text":2026,"url":24,"identifiers":2027},"10.4161\u002Fauto.6.7.12754",{"doi":2026},{"id":24,"text":2029,"url":24,"identifiers":2030},"10.1002\u002Fjcb.25178",{"doi":2029},{"id":24,"text":2032,"url":24,"identifiers":2033},"10.1016\u002FS0304-419X(03)00004-0",{"doi":2032},{"id":24,"text":2035,"url":24,"identifiers":2036},"10.1016\u002Fj.canlet.2011.07.024",{"doi":2035},{"id":24,"text":2038,"url":24,"identifiers":2039},"10.4161\u002Fauto.22037",{"doi":2038},{"id":24,"text":2041,"url":24,"identifiers":2042},"10.3109\u002F10715762.2010.535530",{"doi":2041},{"id":24,"text":2044,"url":24,"identifiers":2045},"10.1007\u002Fs40139-017-0139-5",{"doi":2044},{"id":24,"text":2047,"url":24,"identifiers":2048},"10.1016\u002Fj.freeradbiomed.2016.10.492",{"doi":2047},{"id":24,"text":2050,"url":24,"identifiers":2051},"10.1042\u002FBJ20150658",{"doi":2050},{"id":24,"text":2053,"url":24,"identifiers":2054},"10.1073\u002Fpnas.1819728116",{"doi":2053},{"id":24,"text":2056,"url":24,"identifiers":2057},"10.1038\u002Fcr.2016.95",{"doi":2056},{"id":24,"text":2059,"url":24,"identifiers":2060},"10.1080\u002F15548627.2016.1187366",{"doi":2059},{"id":24,"text":2062,"url":24,"identifiers":2063},"10.3390\u002Fph11040114",{"doi":2062},{"id":24,"text":2065,"url":24,"identifiers":2066},"10.1038\u002Fnature13148",{"doi":2065},{"id":24,"text":2068,"url":24,"identifiers":2069},"10.1038\u002Fncb3053",{"doi":2068},{"id":24,"text":2071,"url":24,"identifiers":2072},"10.1016\u002Fj.freeradbiomed.2018.12.011",{"doi":2071},{"id":24,"text":2074,"url":24,"identifiers":2075},"10.1155\u002F2010\u002F430939",{"doi":2074},{"id":24,"text":2077,"url":24,"identifiers":2078},"10.1016\u002Fj.canlet.2016.07.035",{"doi":2077},{"id":24,"text":2080,"url":24,"identifiers":2081},"10.1038\u002Fcddis.2017.412",{"doi":2080},{"id":24,"text":2083,"url":24,"identifiers":2084},"10.1002\u002Fjcp.21366",{"doi":2083},{"id":24,"text":2086,"url":24,"identifiers":2087},"10.1038\u002Fcddis.2017.272",{"doi":2086},{"id":24,"text":2089,"url":24,"identifiers":2090},"10.1016\u002Fj.bmc.2010.07.031",{"doi":2089},{"id":24,"text":2092,"url":24,"identifiers":2093},"10.1089\u002Fars.2011.4391",{"doi":2092},{"id":24,"text":2095,"url":24,"identifiers":2096},"10.1111\u002Fcas.13728",{"doi":2095},{"id":24,"text":2098,"url":24,"identifiers":2099},"10.1038\u002Fbjc.2014.178",{"doi":2098},{"id":24,"text":2101,"url":24,"identifiers":2102},"10.1016\u002Fj.redox.2015.03.003",{"doi":2101},{"id":24,"text":2104,"url":24,"identifiers":2105},"2015, Anticancer Research, 35, 677",{},{"id":24,"text":2107,"url":24,"identifiers":2108},"10.1038\u002Fsj.bjc.6604485",{"doi":2107},{"id":24,"text":2110,"url":24,"identifiers":2111},"10.1038\u002Fsj.bjc.6600786",{"doi":2110},{"id":24,"text":2113,"url":24,"identifiers":2114},"10.1016\u002Fj.ccr.2011.01.038",{"doi":2113},{"id":24,"text":2116,"url":24,"identifiers":2117},"10.1002\u002Fjcp.21795",{"doi":2116},{"id":24,"text":2119,"url":24,"identifiers":2120},"10.1038\u002Fonc.2008.414",{"doi":2119},{"id":24,"text":2122,"url":24,"identifiers":2123},"10.1016\u002Fj.bmcl.2015.07.018",{"doi":2122},{"id":24,"text":2125,"url":24,"identifiers":2126},"10.1016\u002Fj.freeradbiomed.2017.01.002",{"doi":2125},{"id":24,"text":2128,"url":24,"identifiers":2129},"10.1016\u002Fj.canlet.2015.07.031",{"doi":2128},{"id":24,"text":2131,"url":24,"identifiers":2132},"10.1038\u002Fonc.2015.60",{"doi":2131},{"id":24,"text":2134,"url":24,"identifiers":2135},"10.1159\u002F000100812",{"doi":2134},{"id":24,"text":2137,"url":24,"identifiers":2138},"10.1016\u002Fj.canlet.2018.04.021",{"doi":2137},{"id":24,"text":2140,"url":24,"identifiers":2141},"10.1055\u002Fs-2007-969944",{"doi":2140},{"id":24,"text":2143,"url":24,"identifiers":2144},"10.1074\u002Fjbc.M504604200",{"doi":2143},{"id":24,"text":2146,"url":24,"identifiers":2147},"10.1002\u002Fcyto.a.20434",{"doi":2146},{"id":24,"text":2149,"url":24,"identifiers":2150},"10.1210\u002Fen.2005-0895",{"doi":2149},{"id":24,"text":2152,"url":24,"identifiers":2153},"10.1371\u002Fjournal.pone.0118870",{"doi":2152},{"id":24,"text":2155,"url":24,"identifiers":2156},"10.1016\u002Fj.reprotox.2005.07.011",{"doi":2155},{"id":24,"text":2158,"url":24,"identifiers":2159},"10.1007\u002Fs00280-003-0609-9",{"doi":2158},{"id":24,"text":2161,"url":24,"identifiers":2162},"10.1002\u002Fjnr.23474",{"doi":2161},{"id":24,"text":2164,"url":24,"identifiers":2165},"10.1016\u002Fj.mehy.2017.01.014",{"doi":2164},{"id":24,"text":2167,"url":24,"identifiers":2168},"10.1007\u002Fs10863-012-9422-7",{"doi":2167},{"id":24,"text":2170,"url":24,"identifiers":2171},"10.1016\u002Fj.bbrc.2004.09.047",{"doi":2170},{"id":24,"text":2173,"url":24,"identifiers":2174},"10.1007\u002Fs40495-015-0034-x",{"doi":2173},{"id":24,"text":2176,"url":24,"identifiers":2177},"10.1208\u002Fs12248-009-9162-8",{"doi":2176},{"id":24,"text":2179,"url":24,"identifiers":2180},"10.1002\u002Fmnfr.201300684",{"doi":2179},{"id":24,"text":2182,"url":24,"identifiers":2183},"10.1016\u002Fj.bbcan.2014.08.003",{"doi":2182},{"id":24,"text":2185,"url":24,"identifiers":2186},"10.1016\u002Fj.canlet.2008.04.018",{"doi":2185},{"id":24,"text":2188,"url":24,"identifiers":2189},"10.1177\u002F0960327113491508",{"doi":2188},{"id":24,"text":2191,"url":24,"identifiers":2192},"10.1074\u002Fjbc.M115.688879",{"doi":2191},{"id":24,"text":2194,"url":24,"identifiers":2195},"10.1371\u002Fjournal.pone.0054044",{"doi":2194},{"id":24,"text":2197,"url":24,"identifiers":2198},"10.1016\u002Fj.bcp.2008.09.011",{"doi":2197},{"id":24,"text":2200,"url":24,"identifiers":2201},"10.1074\u002Fjbc.M408531200",{"doi":2200},{"id":24,"text":2203,"url":24,"identifiers":2204},"10.1016\u002Fj.taap.2011.08.004",{"doi":2203},{"id":2206,"createTime":2207,"updateTime":2207,"relativeEntities":2208,"slug":2209,"properties":2210,"entityType":120,"verifyStatus":121,"verifyTime":2207,"verifyNote":122,"syncStatus":23,"languages":2226,"translateLanguages":24,"viewCount":25,"primaryUrl":2227,"fullTextUrl":24,"authors":2228,"publicationType":220,"publisherRelationship":2467,"citationCount":2490,"citationInfo":2491,"publishDate":2493,"publishYear":1713,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2494,"isForceReanalyzing":395},"4e8ba1d4-0868-4588-b091-301eac19d3c6","2024-12-02T22:28:09.738+00:00",[],"A-Metabonomics-Investigation-into-the-Therapeutic-Effects-of-BuChang-NaoXinTong-Capsules-on-Reversing-the-Amino-Acid-Protein-Interaction-Network-of-Cerebral-Ischemia",{"mag":2211,"keywords":2213,"pmc":2214,"openalex":2216,"abstract":2218,"title":2220,"pm":2222,"doi":2224},{"VOID":2212},"2974968455",{},{"VOID":2215},"6446104",{"VOID":2217},"W2974968455",{"EN":2219},"\u003Cjats:p>\u003Cjats:italic>Background\u003C\u002Fjats:italic>. Amino acids (AAs) in cerebrospinal fluid (CSF) play a pivotal role in cerebral ischemia (CI). BuChang NaoXinTong Capsules (BNC) are widely prescribed in Chinese medicine for the treatment of cerebrovascular and cardiovascular diseases. \u003Cjats:italic>Methods\u003C\u002Fjats:italic>. In order to investigate the therapeutic effects and pharmacological mechanisms of BNC on reversing CI from a system level, an amino acid-protein interaction imbalanced network of CI containing metabolites of AAs, key regulatory enzymes, and proteins was constructed for the first time. Furthermore, a novel method for detecting the ten AAs in CSF was developed by UPLC-QQQ-MS in an effort to validate the imbalanced networks and the therapeutic effects of BNC via analysis of metabolites. \u003Cjats:italic>Results\u003C\u002Fjats:italic>. Based on a middle cerebral artery occlusion (MCAO) rat model, the dynamic levels of amino acids in CSF 3, 6, 12, and 24 h after MCAO were analyzed. Up to 24 h, the accumulated nine AA biomarkers were found to significantly change in the MCAO group compared to the sham group and exhibited an obvious tendency for returning to baseline values after BNC treatment. In addition, based on the imbalanced network of CI, four key enzymes that regulate the generation of BNC-mediated AA biomarkers were selected and validated using an enzyme-linked immunosorbent assay and western blotting. Finally, aromatic-L-amino-acid decarboxylase (AADC) was found to be one of the putative targets for BNC-mediated protection against CI. \u003Cjats:italic>Conclusion\u003C\u002Fjats:italic>. This study provides new strategies to explore the mechanism of cerebral ischemia and help discover the potential mechanism of BNC.\u003C\u002Fjats:p>",{"EN":2221},"A Metabonomics Investigation into the Therapeutic Effects of BuChang NaoXinTong Capsules on Reversing the Amino Acid-Protein Interaction Network of Cerebral Ischemia",{"VOID":2223},"31015890",{"VOID":2225},"10.1155\u002F2019\u002F7258624",[124],"https:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fomcl\u002F2019\u002F7258624\u002F",[2229,2251,2272,2292,2309,2326,2342,2364,2381,2398,2415,2433,2450],{"id":2230,"sortIndex":840,"researcher":24,"roles":2231,"affiliations":2232,"properties":2244},"2dd233b5-8b2d-4da3-b82d-9fd665e5d3f1",[],[2233],{"id":2234,"sortIndex":25,"affiliation":2235,"properties":24},"030be95b-7bbe-484b-bf91-784420cb6bf5",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2239,"slug":2240,"properties":2241,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"54d28c63-a386-4219-8139-beccd9ed704b","2024-01-08T09:02:27.560+00:00","2024-12-02T22:28:09.767+00:00",[],"Institute-of-Chinese-Materia-Medica-China-Academy-of-Chinese-Medical-Sciences-Beijing-100700-China",{"title":2242},{"VI":2243},"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China",{"openalex":2245,"orcid":2247,"title":2249},{"VOID":2246},"A5012653405",{"VOID":2248},"https:\u002F\u002Forcid.org\u002F0000-0002-3768-4608",{"EN":2250},"Hongwei Wu",{"id":2252,"sortIndex":204,"researcher":24,"roles":2253,"affiliations":2254,"properties":2265},"b9dad168-913a-4c29-a666-e2fe77649269",[],[2255],{"id":2256,"sortIndex":25,"affiliation":2257,"properties":24},"3f52b262-d6f0-424c-9ed3-116413f220da",{"id":2258,"createTime":2259,"updateTime":2259,"relativeEntities":2260,"slug":2261,"properties":2262,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"3620b823-e0c8-49f6-b82d-a7e18ec9ac92","2024-12-02T22:28:10.003+00:00",[],"Experimental-Research-Centre-China-Academy-of-Chinese-Medical-Sciences-Beijing-100700-China",{"title":2263},{"EN":2264},"Experimental Research Centre, China Academy of Chinese Medical Sciences, Beijing 100700, China",{"openalex":2266,"orcid":2268,"title":2270},{"VOID":2267},"A5017604780",{"VOID":2269},"https:\u002F\u002Forcid.org\u002F0000-0002-3350-3507",{"EN":2271},"Na Guo",{"id":2273,"sortIndex":151,"researcher":24,"roles":2274,"affiliations":2275,"properties":2287},"19c3b452-bbe9-4b42-a189-c6a884cc6d1f",[],[2276],{"id":2277,"sortIndex":25,"affiliation":2278,"properties":24},"d9d12252-8b39-4cd9-8c34-e64fec1035f5",{"id":2279,"createTime":2280,"updateTime":2281,"relativeEntities":2282,"slug":2283,"properties":2284,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"01019d55-ea5b-4f9a-863c-ea25750ba3f4","2024-02-14T07:58:09.028+00:00","2025-06-11T14:29:06.743+00:00",[],"School-of-Pharmaceutical-Science-and-Technology-Tianjin-University-Tianjin-300072-China",{"title":2285},{"VI":2286},"School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China",{"openalex":2288,"title":2290},{"VOID":2289},"A5058339130",{"EN":2291},"Liyu Luo",{"id":2293,"sortIndex":25,"researcher":24,"roles":2294,"affiliations":2295,"properties":2302},"7703ef36-07fc-44dc-b389-311283f64ce7",[],[2296],{"id":2297,"sortIndex":25,"affiliation":2298,"properties":24},"9e175927-2df5-4147-aad9-424ef03d0bb5",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2299,"slug":2240,"properties":2300,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2301},{"VI":2243},{"openalex":2303,"orcid":2305,"title":2307},{"VOID":2304},"A5102009775",{"VOID":2306},"https:\u002F\u002Forcid.org\u002F0000-0002-8926-0890",{"EN":2308},"Jing Xu",{"id":2310,"sortIndex":468,"researcher":24,"roles":2311,"affiliations":2312,"properties":2319},"0a281e3e-2943-434d-a7c5-55488b50f7eb",[],[2313],{"id":2314,"sortIndex":25,"affiliation":2315,"properties":24},"5005672e-2e30-4dbc-ba53-ee9f01ab85d2",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2316,"slug":2240,"properties":2317,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2318},{"VI":2243},{"openalex":2320,"orcid":2322,"title":2324},{"VOID":2321},"A5100388307",{"VOID":2323},"https:\u002F\u002Forcid.org\u002F0000-0003-2783-0998",{"EN":2325},"Yi Zhang",{"id":2327,"sortIndex":2328,"researcher":24,"roles":2329,"affiliations":2330,"properties":2337},"27b4c629-92e1-4988-880d-807f73d1f8a7",10,[],[2331],{"id":2332,"sortIndex":25,"affiliation":2333,"properties":24},"6bb76e0d-f069-44bb-b6d4-6b769b2253cc",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2334,"slug":2240,"properties":2335,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2336},{"VI":2243},{"openalex":2338,"title":2340},{"VOID":2339},"A5101470677",{"EN":2341},"Ye Zhao",{"id":2343,"sortIndex":169,"researcher":24,"roles":2344,"affiliations":2345,"properties":2357},"09541cd2-3ee6-4774-ad72-91dfcc847ffd",[],[2346],{"id":2347,"sortIndex":25,"affiliation":2348,"properties":24},"2f2b5bd4-a409-43b7-b199-a3fc7ab8882f",{"id":2349,"createTime":2350,"updateTime":2351,"relativeEntities":2352,"slug":2353,"properties":2354,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b6420ebc-ea96-4aa9-a020-ead4b8e1c1c4","2023-12-06T16:40:48.170+00:00","2025-01-01T00:52:09.821+00:00",[],"School-of-Chinese-Materia-Medica-Beijing-University-of-Chinese-Medicine-Beijing-100029-China",{"title":2355},{"VI":2356},"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China",{"openalex":2358,"orcid":2360,"title":2362},{"VOID":2359},"A5100621273",{"VOID":2361},"https:\u002F\u002Forcid.org\u002F0000-0003-4094-1211",{"EN":2363},"Xin Liu",{"id":2365,"sortIndex":249,"researcher":24,"roles":2366,"affiliations":2367,"properties":2374},"76fc12c4-ea49-4108-a80b-225943adb7b0",[],[2368],{"id":2369,"sortIndex":25,"affiliation":2370,"properties":24},"83b0926b-4fe8-4e32-ab5d-9ecfc030cf4e",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2371,"slug":2240,"properties":2372,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2373},{"VI":2243},{"openalex":2375,"orcid":2377,"title":2379},{"VOID":2376},"A5100733928",{"VOID":2378},"https:\u002F\u002Forcid.org\u002F0000-0002-4904-6996",{"EN":2380},"Defeng Li",{"id":2382,"sortIndex":248,"researcher":24,"roles":2383,"affiliations":2384,"properties":2391},"ef6b2035-56c0-4f7f-8550-e7fe2251cba7",[],[2385],{"id":2386,"sortIndex":25,"affiliation":2387,"properties":24},"7542a9fb-893c-4848-8f0b-490c7e1c6291",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2388,"slug":2240,"properties":2389,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2390},{"VI":2243},{"openalex":2392,"orcid":2394,"title":2396},{"VOID":2393},"A5063540273",{"VOID":2395},"https:\u002F\u002Forcid.org\u002F0000-0001-5426-0324",{"EN":2397},"Fangbo Zhang",{"id":2399,"sortIndex":129,"researcher":24,"roles":2400,"affiliations":2401,"properties":2408},"0215df14-26aa-4747-b739-15ae380055a7",[],[2402],{"id":2403,"sortIndex":25,"affiliation":2404,"properties":24},"67f8287b-8eb4-45bf-9643-8183d413c10f",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2405,"slug":2240,"properties":2406,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2407},{"VI":2243},{"openalex":2409,"orcid":2411,"title":2413},{"VOID":2410},"A5017454896",{"VOID":2412},"https:\u002F\u002Forcid.org\u002F0000-0002-0555-9191",{"EN":2414},"Liying Tang",{"id":2416,"sortIndex":2417,"researcher":24,"roles":2418,"affiliations":2419,"properties":2426},"fdec5223-e106-4787-9f3e-3bc0bdc6732d",12,[],[2420],{"id":2421,"sortIndex":25,"affiliation":2422,"properties":24},"ea70295a-6378-445b-9058-e1ac5ae903ac",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2423,"slug":2240,"properties":2424,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2425},{"VI":2243},{"openalex":2427,"orcid":2429,"title":2431},{"VOID":2428},"A5063633828",{"VOID":2430},"https:\u002F\u002Forcid.org\u002F0000-0001-5501-3288",{"EN":2432},"Hongjun Yang",{"id":2434,"sortIndex":467,"researcher":24,"roles":2435,"affiliations":2436,"properties":2443},"b016b91c-fb44-4be7-ab02-044686d68587",[],[2437],{"id":2438,"sortIndex":25,"affiliation":2439,"properties":24},"3d13fd61-7f1a-40fd-ad97-e39c63603bbc",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2440,"slug":2240,"properties":2441,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2442},{"VI":2243},{"openalex":2444,"orcid":2446,"title":2448},{"VOID":2445},"A5100749073",{"VOID":2447},"https:\u002F\u002Forcid.org\u002F0000-0001-7061-8189",{"EN":2449},"Hongmei Li",{"id":2451,"sortIndex":469,"researcher":24,"roles":2452,"affiliations":2453,"properties":2460},"836559ce-7994-4fd0-be20-0b2a35ae1784",[],[2454],{"id":2455,"sortIndex":25,"affiliation":2456,"properties":24},"6bd4a832-98f6-4e02-bd68-95b3733f42bf",{"id":2236,"createTime":2237,"updateTime":2238,"relativeEntities":2457,"slug":2240,"properties":2458,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2459},{"VI":2243},{"openalex":2461,"orcid":2463,"title":2465},{"VOID":2462},"A5100620510",{"VOID":2464},"https:\u002F\u002Forcid.org\u002F0000-0001-9167-733X",{"EN":2466},"Mengting Liu",{"url":24,"publisher":2468,"properties":2486},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2469,"slug":10,"properties":2470,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2476,"manageAffiliations":2477,"indexDatabases":2478,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2471,"issn":2472,"introduce":2473,"eissn":2474,"title":2475},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2479],{"id":73,"indexDatabase":2480,"url":86,"indexYears":87,"academicFieldIds":2485,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":2481,"label":2482,"description":2483,"key":83,"publicationTags":2484,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":2487,"pages":2488},{"VOID":1701},{"VOID":2489},"1-14",20,{"total":2490,"publishYear":24,"statisticByYear":2492},{"2018":169,"2019":169,"2020":467,"2021":151,"2022":204,"2023":204,"2024":151},"2019-03-20",[2495,2498,2501,2504,2507,2510,2513,2516,2519,2522,2525,2528,2531,2534,2537,2540,2543,2546,2549,2552,2555,2558,2561,2564,2567,2570,2573,2576,2579,2582,2585,2588,2591,2594,2597,2600,2603,2606,2609,2612,2615,2618,2621,2624,2627,2630,2633,2636,2639,2642,2645,2648,2651,2654],{"id":24,"text":2496,"url":24,"identifiers":2497},"10.1111\u002Fj.1365-2796.2009.02205.x",{"doi":2496},{"id":24,"text":2499,"url":24,"identifiers":2500},"10.1016\u002Fj.neures.2009.03.016",{"doi":2499},{"id":24,"text":2502,"url":24,"identifiers":2503},"10.1073\u002Fpnas.1416166111",{"doi":2502},{"id":24,"text":2505,"url":24,"identifiers":2506},"10.1111\u002Fcns.12576",{"doi":2505},{"id":24,"text":2508,"url":24,"identifiers":2509},"10.1016\u002Fj.apsb.2014.11.002",{"doi":2508},{"id":24,"text":2511,"url":24,"identifiers":2512},"10.1016\u002Fj.jpba.2015.01.020",{"doi":2511},{"id":24,"text":2514,"url":24,"identifiers":2515},"10.1039\u002Fc5mb00460h",{"doi":2514},{"id":24,"text":2517,"url":24,"identifiers":2518},"2015",{},{"id":24,"text":2520,"url":24,"identifiers":2521},"10.1155\u002F2018\u002F5892306",{"doi":2520},{"id":24,"text":2523,"url":24,"identifiers":2524},"10.1007\u002Fs11655-014-2023-z",{"doi":2523},{"id":24,"text":2526,"url":24,"identifiers":2527},"10.1155\u002F2018\u002F8485472",{"doi":2526},{"id":24,"text":2529,"url":24,"identifiers":2530},"10.1371\u002Fjournal.pone.0160285",{"doi":2529},{"id":24,"text":2532,"url":24,"identifiers":2533},"10.1016\u002Fj.jep.2016.02.022",{"doi":2532},{"id":24,"text":2535,"url":24,"identifiers":2536},"10.1111\u002Fjcmm.12915",{"doi":2535},{"id":24,"text":2538,"url":24,"identifiers":2539},"10.1155\u002F2012\u002F430262",{"doi":2538},{"id":24,"text":2541,"url":24,"identifiers":2542},"10.1155\u002F2011\u002F207034",{"doi":2541},{"id":24,"text":2544,"url":24,"identifiers":2545},"10.1155\u002F2013\u002F802784",{"doi":2544},{"id":24,"text":2547,"url":24,"identifiers":2548},"10.1049\u002Fiet-syb:20060032",{"doi":2547},{"id":24,"text":2550,"url":24,"identifiers":2551},"10.3736\u002Fjcim20070501",{"doi":2550},{"id":24,"text":2553,"url":24,"identifiers":2554},"10.1038\u002Fnchembio.118",{"doi":2553},{"id":24,"text":2556,"url":24,"identifiers":2557},"10.1016\u002Fj.jpba.2017.08.050",{"doi":2556},{"id":24,"text":2559,"url":24,"identifiers":2560},"10.1007\u002Fs00726-004-0073-9",{"doi":2559},{"id":24,"text":2562,"url":24,"identifiers":2563},"10.1038\u002Fnpp.2011.285",{"doi":2562},{"id":24,"text":2565,"url":24,"identifiers":2566},"10.1186\u002Fs40364-017-0104-9",{"doi":2565},{"id":24,"text":2568,"url":24,"identifiers":2569},"10.1038\u002Ftp.2016.8",{"doi":2568},{"id":24,"text":2571,"url":24,"identifiers":2572},"10.1038\u002Fsrep07796",{"doi":2571},{"id":24,"text":2574,"url":24,"identifiers":2575},"10.1161\u002Fhs1101.097380",{"doi":2574},{"id":24,"text":2577,"url":24,"identifiers":2578},"10.2217\u002Ffnl.11.55",{"doi":2577},{"id":24,"text":2580,"url":24,"identifiers":2581},"10.1016\u002Fj.jep.2016.01.016",{"doi":2580},{"id":24,"text":2583,"url":24,"identifiers":2584},"10.1007\u002F978-94-024-1079-2_81",{"doi":2583},{"id":24,"text":2586,"url":24,"identifiers":2587},"10.1016\u002Fj.vascn.2018.02.002",{"doi":2586},{"id":24,"text":2589,"url":24,"identifiers":2590},"10.1016\u002Fj.jchromb.2013.05.014",{"doi":2589},{"id":24,"text":2592,"url":24,"identifiers":2593},"10.1016\u002Fj.jpba.2013.07.046",{"doi":2592},{"id":24,"text":2595,"url":24,"identifiers":2596},"10.1016\u002Fj.cca.2017.12.027",{"doi":2595},{"id":24,"text":2598,"url":24,"identifiers":2599},"10.1016\u002Fj.jpba.2015.06.015",{"doi":2598},{"id":24,"text":2601,"url":24,"identifiers":2602},"10.1016\u002Fj.jchromb.2013.09.011",{"doi":2601},{"id":24,"text":2604,"url":24,"identifiers":2605},"10.1016\u002Fj.jpba.2016.05.019",{"doi":2604},{"id":24,"text":2607,"url":24,"identifiers":2608},"10.1155\u002F2016\u002F9162074",{"doi":2607},{"id":24,"text":2610,"url":24,"identifiers":2611},"10.1038\u002Fnprot.2008.211",{"doi":2610},{"id":24,"text":2613,"url":24,"identifiers":2614},"10.1038\u002Fnprot.2008.100",{"doi":2613},{"id":24,"text":2616,"url":24,"identifiers":2617},"10.1161\u002F01.STR.20.1.84",{"doi":2616},{"id":24,"text":2619,"url":24,"identifiers":2620},"10.1016\u002Fj.apsb.2015.02.001",{"doi":2619},{"id":24,"text":2622,"url":24,"identifiers":2623},"10.1038\u002Fsrep04154",{"doi":2622},{"id":24,"text":2625,"url":24,"identifiers":2626},"10.1038\u002Fsrep09463",{"doi":2625},{"id":24,"text":2628,"url":24,"identifiers":2629},"10.1016\u002Fj.tox.2018.05.014",{"doi":2628},{"id":24,"text":2631,"url":24,"identifiers":2632},"10.1038\u002Fs41419-018-0784-6",{"doi":2631},{"id":24,"text":2634,"url":24,"identifiers":2635},"10.1523\u002Fjneurosci.22-23-10302.2002",{"doi":2634},{"id":24,"text":2637,"url":24,"identifiers":2638},"10.1111\u002Fj.1755-5949.2008.00058.x",{"doi":2637},{"id":24,"text":2640,"url":24,"identifiers":2641},"10.1111\u002Fj.1471-4159.1988.tb01111.x",{"doi":2640},{"id":24,"text":2643,"url":24,"identifiers":2644},"10.1016\u002FS0006-8993(02)02315-6",{"doi":2643},{"id":24,"text":2646,"url":24,"identifiers":2647},"10.1371\u002Fjournal.pone.0071741",{"doi":2646},{"id":24,"text":2649,"url":24,"identifiers":2650},"10.1007\u002Fs42000-018-0007-7",{"doi":2649},{"id":24,"text":2652,"url":24,"identifiers":2653},"10.1016\u002Fj.nbd.2013.06.007",{"doi":2652},{"id":24,"text":2655,"url":24,"identifiers":2656},"10.4314\u002Fahs.v14i3.31",{"doi":2655},{"id":2658,"createTime":2659,"updateTime":2659,"relativeEntities":2660,"slug":2661,"properties":2662,"entityType":120,"verifyStatus":121,"verifyTime":2677,"verifyNote":122,"syncStatus":23,"languages":2678,"translateLanguages":24,"viewCount":25,"primaryUrl":2679,"fullTextUrl":24,"authors":2680,"publicationType":220,"publisherRelationship":2736,"citationCount":2758,"citationInfo":2759,"publishDate":2761,"publishYear":2762,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2763,"isForceReanalyzing":395},"49816925-d5d3-4917-ac0e-2acd7781b085","2024-09-12T22:19:34.694+00:00",[],"TPEN-Induces-Apoptosis-Independently-of-Zinc-Chelator-Activity-in-a-Model-of-Acute-Lymphoblastic-Leukemia-and-i-Ex-Vivo-i-Acute-Leukemia-Cells-through-Oxidative-Stress-and-Mitochondria-Caspase-3-and-AIF-Dependent-Pathways",{"mag":2663,"keywords":2665,"pmc":2666,"openalex":2668,"abstract":2670,"title":2671,"pm":2673,"doi":2675},{"VOID":2664},"1988875965",{},{"VOID":2667},"3540963",{"VOID":2669},"W1988875965",{},{"EN":2672},"TPEN Induces Apoptosis Independently of Zinc Chelator Activity in a Model of Acute Lymphoblastic Leukemia and\u003Ci>Ex Vivo\u003C\u002Fi>Acute Leukemia Cells through Oxidative Stress and Mitochondria Caspase-3- and AIF-Dependent Pathways",{"VOID":2674},"23320127",{"VOID":2676},"10.1155\u002F2012\u002F313275","2024-09-12T22:19:34.693+00:00",[124],"http:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fomcl\u002F2012\u002F313275\u002F",[2681,2702,2719],{"id":2682,"sortIndex":151,"researcher":24,"roles":2683,"affiliations":2684,"properties":2695},"d0590dd6-22c2-4fc5-8669-8f3024f846d7",[],[2685],{"id":2686,"sortIndex":25,"affiliation":2687,"properties":24},"6b55c592-ffa8-4a43-8c93-09e593d0484a",{"id":2688,"createTime":2689,"updateTime":2689,"relativeEntities":2690,"slug":2691,"properties":2692,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"add42f44-9f43-4f99-b3a7-5b19ba8d405a","2024-09-12T22:19:34.716+00:00",[],"Neuroscience-Research-Group-Medical-Research-Institute-School-of-Medicine-University-of-Antioquia-UdeA-Calle-62-No-52-59-Building-1-Laboratory-411-412-SIU-Medellin-Colombia",{"title":2693},{"EN":2694},"Neuroscience Research Group, Medical Research Institute School of Medicine, University of Antioquia (UdeA), Calle 62 No. 52-59, Building 1, Laboratory 411\u002F412, SIU, Medellin, Colombia",{"openalex":2696,"orcid":2698,"title":2700},{"VOID":2697},"A5033560020",{"VOID":2699},"https:\u002F\u002Forcid.org\u002F0000-0003-3477-2386",{"EN":2701},"Marlene Jiménez-Del-Río",{"id":2703,"sortIndex":169,"researcher":24,"roles":2704,"affiliations":2705,"properties":2712},"cfb6a3d1-8888-4bc7-a464-cc34f83daaad",[],[2706],{"id":2707,"sortIndex":25,"affiliation":2708,"properties":24},"448c94b0-4409-468e-b774-f6b8e2b846ec",{"id":2688,"createTime":2689,"updateTime":2689,"relativeEntities":2709,"slug":2691,"properties":2710,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2711},{"EN":2694},{"openalex":2713,"orcid":2715,"title":2717},{"VOID":2714},"A5042019799",{"VOID":2716},"https:\u002F\u002Forcid.org\u002F0000-0002-0557-0411",{"EN":2718},"Carlos Velez‐Pardo",{"id":2720,"sortIndex":25,"researcher":24,"roles":2721,"affiliations":2722,"properties":2729},"71bf4464-e6a0-453a-9ca7-8b84487107be",[],[2723],{"id":2724,"sortIndex":25,"affiliation":2725,"properties":24},"862147c2-5248-4d52-b956-aee719a55042",{"id":2688,"createTime":2689,"updateTime":2689,"relativeEntities":2726,"slug":2691,"properties":2727,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2728},{"EN":2694},{"openalex":2730,"orcid":2732,"title":2734},{"VOID":2731},"A5024066765",{"VOID":2733},"https:\u002F\u002Forcid.org\u002F0000-0002-8824-379X",{"EN":2735},"Miguel Mendivil‐Perez",{"url":24,"publisher":2737,"properties":2755},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2738,"slug":10,"properties":2739,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2745,"manageAffiliations":2746,"indexDatabases":2747,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2740,"issn":2741,"introduce":2742,"eissn":2743,"title":2744},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2748],{"id":73,"indexDatabase":2749,"url":86,"indexYears":87,"academicFieldIds":2754,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":2750,"label":2751,"description":2752,"key":83,"publicationTags":2753,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":2756,"pages":2757},{"VOID":351},{"VOID":2489},64,{"total":2758,"publishYear":24,"statisticByYear":2760},{"2013":129,"2014":151,"2015":840,"2016":469,"2017":129,"2018":169,"2019":467,"2020":469,"2021":248,"2022":249,"2023":468,"2024":204},"2012-01-01",2012,[2764,2768,2771,2774,2778,2781,2784,2787,2790,2793,2796,2799,2802,2805,2809,2813,2816,2819,2823,2826,2829,2832,2835,2838,2841,2845,2848,2851,2854,2857,2860,2863,2866,2869,2872,2876,2879,2883,2886,2890,2893,2895,2898,2902,2905,2908,2911,2915,2918,2921,2924,2928,2931,2935,2938,2942,2946,2949,2952,2956,2959,2962,2965,2969,2973],{"id":24,"text":2765,"url":24,"identifiers":2766},"2012, A Cancer Journal for Clinicians, 62, 10, 10.3322\u002Fcaac.20138",{"doi":2767},"10.3322\u002Fcaac.20138",{"id":24,"text":2769,"url":24,"identifiers":2770},"10.1007\u002Fs004320050228",{"doi":2769},{"id":24,"text":2772,"url":24,"identifiers":2773},"10.1056\u002FNEJMra023001",{"doi":2772},{"id":24,"text":2775,"url":24,"identifiers":2776},"2000, Cell, 100, 57, 10.1016\u002FS0092-8674(00)81683-9",{"doi":2777},"10.1016\u002FS0092-8674(00)81683-9",{"id":24,"text":2779,"url":24,"identifiers":2780},"10.1093\u002Fcarcin\u002Fbgp070",{"doi":2779},{"id":24,"text":2782,"url":24,"identifiers":2783},"10.1016\u002FS0091-679X(08)61921-4",{"doi":2782},{"id":24,"text":2785,"url":24,"identifiers":2786},"10.1038\u002Fcdd.2008.150",{"doi":2785},{"id":24,"text":2788,"url":24,"identifiers":2789},"10.1038\u002Fcdd.2011.96",{"doi":2788},{"id":24,"text":2791,"url":24,"identifiers":2792},"10.1182\u002Fblood-2009-01-198911",{"doi":2791},{"id":24,"text":2794,"url":24,"identifiers":2795},"10.1016\u002FB978-0-12-385524-4.00002-7",{"doi":2794},{"id":24,"text":2797,"url":24,"identifiers":2798},"10.1309\u002FAJCPYWC6AQC7BAVJ",{"doi":2797},{"id":24,"text":2800,"url":24,"identifiers":2801},"10.4149\u002Fneo_2010_02_170",{"doi":2800},{"id":24,"text":2803,"url":24,"identifiers":2804},"2011, Mediterranean Journal of Hematology and Infectious Diseases, 3",{},{"id":24,"text":2806,"url":24,"identifiers":2807},"2000, American Journal of Pathology, 157, 1415, 10.1016\u002FS0002-9440(10)64779-7",{"doi":2808},"10.1016\u002FS0002-9440(10)64779-7",{"id":24,"text":2810,"url":24,"identifiers":2811},"2012, Advances in Experimental Medicine and Biology, 727, 199, 10.1007\u002F978-1-4614-0899-4_15",{"doi":2812},"10.1007\u002F978-1-4614-0899-4_15",{"id":24,"text":2814,"url":24,"identifiers":2815},"2006, Biological Trace Element Research, 114, 41",{},{"id":24,"text":2817,"url":24,"identifiers":2818},"10.1002\u002Fjcp.22140",{"doi":2817},{"id":24,"text":2820,"url":24,"identifiers":2821},"1993, Physiological Reviews, 73, 79, 10.1152\u002Fphysrev.1993.73.1.79",{"doi":2822},"10.1152\u002Fphysrev.1993.73.1.79",{"id":24,"text":2824,"url":24,"identifiers":2825},"10.3390\u002Fijerph7041342",{"doi":2824},{"id":24,"text":2827,"url":24,"identifiers":2828},"10.1016\u002Fj.bcp.2003.12.036",{"doi":2827},{"id":24,"text":2830,"url":24,"identifiers":2831},"10.1517\u002F13543780902845622",{"doi":2830},{"id":24,"text":2833,"url":24,"identifiers":2834},"1999, NeuroToxicology, 20, 571",{},{"id":24,"text":2836,"url":24,"identifiers":2837},"10.1002\u002Fjcb.21613",{"doi":2836},{"id":24,"text":2839,"url":24,"identifiers":2840},"10.1016\u002Fj.ejphar.2006.11.010",{"doi":2839},{"id":24,"text":2842,"url":24,"identifiers":2843},"1997, Cell Death and Differentiation, 4, 39, 10.1038\u002Fsj.cdd.4400204",{"doi":2844},"10.1038\u002Fsj.cdd.4400204",{"id":24,"text":2846,"url":24,"identifiers":2847},"10.1038\u002Fcdd.2008.106",{"doi":2846},{"id":24,"text":2849,"url":24,"identifiers":2850},"10.1016\u002Fj.brainres.2008.08.040",{"doi":2849},{"id":24,"text":2852,"url":24,"identifiers":2853},"10.1023\u002FA:1012497926537",{"doi":2852},{"id":24,"text":2855,"url":24,"identifiers":2856},"10.1016\u002Fj.febslet.2008.04.056",{"doi":2855},{"id":24,"text":2858,"url":24,"identifiers":2859},"10.1111\u002Fj.1538-7836.2009.03431.x",{"doi":2858},{"id":24,"text":2861,"url":24,"identifiers":2862},"10.1006\u002Fexcr.2001.5222",{"doi":2861},{"id":24,"text":2864,"url":24,"identifiers":2865},"10.1016\u002Fj.febslet.2009.04.008",{"doi":2864},{"id":24,"text":2867,"url":24,"identifiers":2868},"2012, Oxidative Medicine and Cellular Longevity, 2012",{},{"id":24,"text":2870,"url":24,"identifiers":2871},"10.1042\u002FBJ20011856",{"doi":2870},{"id":24,"text":2873,"url":24,"identifiers":2874},"2012, The Journal of Experimental Medicine, 209, 211, 10.1084\u002Fjem.20120162",{"doi":2875},"10.1084\u002Fjem.20120162",{"id":24,"text":2877,"url":24,"identifiers":2878},"10.1186\u002F1475-2867-11-19",{"doi":2877},{"id":24,"text":2880,"url":24,"identifiers":2881},"1987, Journal of Leukocyte Biology, 41, 325, 10.1002\u002Fjlb.41.4.325",{"doi":2882},"10.1002\u002Fjlb.41.4.325",{"id":24,"text":2884,"url":24,"identifiers":2885},"10.1097\u002FMCO.0b013e32833a5577",{"doi":2884},{"id":24,"text":2887,"url":24,"identifiers":2888},"2011, Antioxidants and Redox Signaling, 15, 2335, 10.1089\u002Fars.2010.3534",{"doi":2889},"10.1089\u002Fars.2010.3534",{"id":24,"text":2891,"url":24,"identifiers":2892},"10.1038\u002Fsj.onc.1209542",{"doi":2891},{"id":24,"text":1030,"url":24,"identifiers":2894},{"doi":1030},{"id":24,"text":2896,"url":24,"identifiers":2897},"10.1016\u002FS0092-8674(00)81842-5",{"doi":2896},{"id":24,"text":2899,"url":24,"identifiers":2900},"2000, Journal of Immunology, 164, 4292, 10.4049\u002Fjimmunol.164.8.4292",{"doi":2901},"10.4049\u002Fjimmunol.164.8.4292",{"id":24,"text":2903,"url":24,"identifiers":2904},"10.1074\u002Fjbc.M212389200",{"doi":2903},{"id":24,"text":2906,"url":24,"identifiers":2907},"10.1007\u002F978-1-4020-6554-5_11",{"doi":2906},{"id":24,"text":2909,"url":24,"identifiers":2910},"10.1016\u002Fj.bbcan.2006.02.001",{"doi":2909},{"id":24,"text":2912,"url":24,"identifiers":2913},"1994, Journal of Biological Chemistry, 269, 20067, 10.1016\u002FS0021-9258(17)32128-2",{"doi":2914},"10.1016\u002FS0021-9258(17)32128-2",{"id":24,"text":2916,"url":24,"identifiers":2917},"10.1016\u002Fj.bbabio.2008.10.005",{"doi":2916},{"id":24,"text":2919,"url":24,"identifiers":2920},"10.1016\u002Fj.semcancer.2008.11.005",{"doi":2919},{"id":24,"text":2922,"url":24,"identifiers":2923},"10.1038\u002Faps.2010.151",{"doi":2922},{"id":24,"text":2925,"url":24,"identifiers":2926},"2012, Leukemia, 26, 910, 10.1038\u002Fleu.2011.315",{"doi":2927},"10.1038\u002Fleu.2011.315",{"id":24,"text":2929,"url":24,"identifiers":2930},"10.1136\u002Fjcp.2009.070961",{"doi":2929},{"id":24,"text":2932,"url":24,"identifiers":2933},"2012, Leukemia, 26, 623, 10.1038\u002Fleu.2011.249",{"doi":2934},"10.1038\u002Fleu.2011.249",{"id":24,"text":2936,"url":24,"identifiers":2937},"10.1096\u002Ffj.10-160549",{"doi":2936},{"id":24,"text":2939,"url":24,"identifiers":2940},"1999, Journal of Histochemistry and Cytochemistry, 47, 1101, 10.1177\u002F002215549904700901",{"doi":2941},"10.1177\u002F002215549904700901",{"id":24,"text":2943,"url":24,"identifiers":2944},"2007, Cell Cycle, 6, 2612, 10.4161\u002Fcc.6.21.4842",{"doi":2945},"10.4161\u002Fcc.6.21.4842",{"id":24,"text":2947,"url":24,"identifiers":2948},"10.1038\u002Fsj.cdd.4401965",{"doi":2947},{"id":24,"text":2950,"url":24,"identifiers":2951},"10.1016\u002Fj.phrs.2010.12.001",{"doi":2950},{"id":24,"text":2953,"url":24,"identifiers":2954},"2012, Molecular and Cellular Biochemistry, 361, 209, 10.1007\u002Fs11010-011-1105-x",{"doi":2955},"10.1007\u002Fs11010-011-1105-x",{"id":24,"text":2957,"url":24,"identifiers":2958},"10.1074\u002Fjbc.272.30.18530",{"doi":2957},{"id":24,"text":2960,"url":24,"identifiers":2961},"10.1007\u002Fs10059-009-0149-1",{"doi":2960},{"id":24,"text":2963,"url":24,"identifiers":2964},"10.1128\u002FMCB.21.8.2743-2754.2001",{"doi":2963},{"id":24,"text":2966,"url":24,"identifiers":2967},"2011, Food and Chemical Toxicology, 49, 3046, 10.1016\u002Fj.fct.2011.10.001",{"doi":2968},"10.1016\u002Fj.fct.2011.10.001",{"id":24,"text":2970,"url":24,"identifiers":2971},"Leukemia, 26, 2245, 10.1038\u002Fleu.2012.101",{"doi":2972},"10.1038\u002Fleu.2012.101",{"id":24,"text":2974,"url":24,"identifiers":2975},"2012, The New England Journal of Medicine, 366, 1371, 10.1056\u002FNEJMoa1110169",{"doi":2976},"10.1056\u002FNEJMoa1110169",{"id":2978,"createTime":2979,"updateTime":2979,"relativeEntities":2980,"slug":2981,"properties":2982,"entityType":120,"verifyStatus":121,"verifyTime":2998,"verifyNote":122,"syncStatus":23,"languages":2999,"translateLanguages":24,"viewCount":25,"primaryUrl":3000,"fullTextUrl":24,"authors":3001,"publicationType":220,"publisherRelationship":3041,"citationCount":3064,"citationInfo":3065,"publishDate":3071,"publishYear":3072,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":3073,"isForceReanalyzing":395},"031cd101-9be7-4112-8855-35649ce14c0f","2024-09-12T22:19:28.767+00:00",[],"Increased-Oxidative-Stress-as-a-Selective-Anticancer-Therapy",{"mag":2983,"keywords":2985,"pmc":2986,"openalex":2988,"abstract":2990,"title":2992,"pm":2994,"doi":2996},{"VOID":2984},"1536274572",{},{"VOID":2987},"4529973",{"VOID":2989},"W1536274572",{"EN":2991},"\u003Cjats:p>Reactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in the promotion of the upregulation of CSC markers, and the reduction of intracellular ROS level, thus facilitating CSCs survival and proliferation. Although the ROS level is regulated by powerful antioxidant defense mechanisms in cancer cells, it is observed to remain higher than that in normal cells. Cancer cells may be more sensitive than normal cells to the accumulation of ROS; consequently, it is supposed that increased oxidative stress by exogenous ROS generation therapy has an effect on selectively killing cancer cells without affecting normal cells. This paper reviews the mechanisms of redox regulation in CSCs and the pivotal role of ROS in anticancer treatment.\u003C\u002Fjats:p>",{"EN":2993},"Increased Oxidative Stress as a Selective Anticancer Therapy",{"VOID":2995},"26273420",{"VOID":2997},"10.1155\u002F2015\u002F294303","2024-09-12T22:19:28.766+00:00",[124],"http:\u002F\u002Fwww.hindawi.com\u002Fjournals\u002Fomcl\u002F2015\u002F294303\u002F",[3002,3024],{"id":3003,"sortIndex":169,"researcher":24,"roles":3004,"affiliations":3005,"properties":3017},"fcb95c61-8b68-488b-8e51-59d6f3c7d57b",[],[3006],{"id":3007,"sortIndex":25,"affiliation":3008,"properties":24},"0065397f-b7b6-4c4e-b5d7-a8b5bf15abff",{"id":3009,"createTime":3010,"updateTime":3011,"relativeEntities":3012,"slug":3013,"properties":3014,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"52ecbfc7-c929-48e3-bd63-b0daf432f5f6","2024-02-08T20:27:53.349+00:00","2024-09-12T22:19:28.780+00:00",[],"State-Key-Laboratory-of-Ophthalmology-Zhongshan-Ophthalmic-Center-Sun-Yat-sen-University-54-Xian-Lie-Nan-Road-Guangzhou-510060-China",{"title":3015},{"VI":3016},"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xian Lie Nan Road, Guangzhou 510060, China",{"openalex":3018,"orcid":3020,"title":3022},{"VOID":3019},"A5101912996",{"VOID":3021},"https:\u002F\u002Forcid.org\u002F0000-0002-5984-0990",{"EN":3023},"Zhichong Wang",{"id":3025,"sortIndex":25,"researcher":24,"roles":3026,"affiliations":3027,"properties":3034},"d74777e5-c971-4515-96c6-ddc24e042f05",[],[3028],{"id":3029,"sortIndex":25,"affiliation":3030,"properties":24},"aef65d12-9125-4ad3-be34-33628a57df2d",{"id":3009,"createTime":3010,"updateTime":3011,"relativeEntities":3031,"slug":3013,"properties":3032,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":3033},{"VI":3016},{"openalex":3035,"orcid":3037,"title":3039},{"VOID":3036},"A5100325997",{"VOID":3038},"https:\u002F\u002Forcid.org\u002F0000-0001-6496-435X",{"EN":3040},"Jiahui Liu",{"url":24,"publisher":3042,"properties":3060},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":3043,"slug":10,"properties":3044,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":3050,"manageAffiliations":3051,"indexDatabases":3052,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":3045,"issn":3046,"introduce":3047,"eissn":3048,"title":3049},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[3053],{"id":73,"indexDatabase":3054,"url":86,"indexYears":87,"academicFieldIds":3059,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":3055,"label":3056,"description":3057,"key":83,"publicationTags":3058,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":3061,"pages":3062},{"VOID":2517},{"VOID":3063},"1-12",163,{"total":3064,"publishYear":24,"statisticByYear":3066},{"2015":169,"2016":249,"2017":2417,"2018":3067,"2019":3068,"2020":842,"2021":3069,"2022":3070,"2023":2417,"2024":249},18,24,23,39,"2015-01-01",2015,[3074,3077,3080,3083,3086,3089,3092,3095,3098,3101,3104,3107,3110,3113,3116,3119,3122,3125,3128,3132,3135,3138,3141,3144,3147,3150,3154,3157,3160,3164,3168,3171,3174,3177,3180,3183,3186,3189,3192,3195,3198,3201,3204,3207,3210,3213,3216,3218,3221,3224,3227,3230,3233,3236,3239,3242,3245,3248,3250,3253,3256,3259,3262,3265,3268,3271,3274,3277,3280,3283,3286,3289,3292,3295,3298,3301,3304,3307,3310,3313,3316,3319,3322,3325,3328,3331,3334,3337,3340,3343,3346,3349,3352,3355,3358,3361,3364,3367,3370,3373,3376,3379,3382,3385,3388,3391,3394,3397,3400,3403,3406,3409,3412,3415,3418,3421,3425,3428,3431,3434,3437,3440,3443,3446,3449,3452,3455,3458,3461,3464,3467,3470,3473,3476,3479,3482,3485,3488,3491,3494,3497,3500,3503,3506,3509,3512,3515,3518,3521,3524,3527,3530,3533,3536,3539,3542,3545,3548,3551,3554,3558,3561,3564,3567,3570,3573,3576,3579,3582,3585,3588,3590,3593,3596,3598,3601,3604,3607,3610,3613,3617,3621,3624,3627,3630,3633,3636,3639,3642,3645,3648,3651,3653,3656,3659,3662,3665,3668,3671,3674,3677,3680,3683,3686,3689,3692,3695,3698,3701],{"id":24,"text":3075,"url":24,"identifiers":3076},"10.1089\u002Fars.2011.4414",{"doi":3075},{"id":24,"text":3078,"url":24,"identifiers":3079},"10.1038\u002Fnrd2803",{"doi":3078},{"id":24,"text":3081,"url":24,"identifiers":3082},"10.3109\u002F10715768909087918",{"doi":3081},{"id":24,"text":3084,"url":24,"identifiers":3085},"10.1016\u002Fs1369-5274(99)80033-2",{"doi":3084},{"id":24,"text":3087,"url":24,"identifiers":3088},"10.1016\u002F0891-5849(94)00198-s",{"doi":3087},{"id":24,"text":3090,"url":24,"identifiers":3091},"10.1038\u002F367645a0",{"doi":3090},{"id":24,"text":3093,"url":24,"identifiers":3094},"10.1038\u002Fnrc3184",{"doi":3093},{"id":24,"text":3096,"url":24,"identifiers":3097},"10.1158\u002F0008-5472.can-06-3126",{"doi":3096},{"id":24,"text":3099,"url":24,"identifiers":3100},"10.1016\u002Fj.canlet.2012.03.018",{"doi":3099},{"id":24,"text":3102,"url":24,"identifiers":3103},"10.1016\u002Fj.urolonc.2005.11.031",{"doi":3102},{"id":24,"text":3105,"url":24,"identifiers":3106},"10.1634\u002Ftheoncologist.2012-0163",{"doi":3105},{"id":24,"text":3108,"url":24,"identifiers":3109},"10.1038\u002Fnm0909-1010",{"doi":3108},{"id":24,"text":3111,"url":24,"identifiers":3112},"10.1016\u002Fj.cell.2006.03.011",{"doi":3111},{"id":24,"text":3114,"url":24,"identifiers":3115},"10.1016\u002Fj.cell.2009.08.017",{"doi":3114},{"id":24,"text":3117,"url":24,"identifiers":3118},"10.1038\u002Fnrc1590",{"doi":3117},{"id":24,"text":3120,"url":24,"identifiers":3121},"10.1038\u002F35102167",{"doi":3120},{"id":24,"text":3123,"url":24,"identifiers":3124},"10.1016\u002Fj.addr.2013.09.016",{"doi":3123},{"id":24,"text":3126,"url":24,"identifiers":3127},"10.1016\u002Fj.cell.2005.02.001",{"doi":3126},{"id":24,"text":3129,"url":24,"identifiers":3130},"1979, Physiological Reviews, 59, 527, 10.1152\u002Fphysrev.1979.59.3.527",{"doi":3131},"10.1152\u002Fphysrev.1979.59.3.527",{"id":24,"text":3133,"url":24,"identifiers":3134},"10.1089\u002Fars.2009.2804",{"doi":3133},{"id":24,"text":3136,"url":24,"identifiers":3137},"10.1021\u002Fbi00906a038",{"doi":3136},{"id":24,"text":3139,"url":24,"identifiers":3140},"10.1515\u002Fbc.2002.040",{"doi":3139},{"id":24,"text":3142,"url":24,"identifiers":3143},"10.1016\u002F0891-5849(94)90079-5",{"doi":3142},{"id":24,"text":3145,"url":24,"identifiers":3146},"10.1089\u002Fars.2012.4529",{"doi":3145},{"id":24,"text":3148,"url":24,"identifiers":3149},"10.1111\u002Fj.1753-4887.2012.00476.x",{"doi":3148},{"id":24,"text":3151,"url":24,"identifiers":3152},"2002, Physiological Reviews, 82, 47, 10.1152\u002Fphysrev.00018.2001",{"doi":3153},"10.1152\u002Fphysrev.00018.2001",{"id":24,"text":3155,"url":24,"identifiers":3156},"10.1038\u002Fnature10167",{"doi":3155},{"id":24,"text":3158,"url":24,"identifiers":3159},"10.1038\u002Fsj.cdd.4402165",{"doi":3158},{"id":24,"text":3161,"url":24,"identifiers":3162},"1999, Blood, 93, 2928, 10.1182\u002Fblood.V93.9.2928",{"doi":3163},"10.1182\u002Fblood.V93.9.2928",{"id":24,"text":3165,"url":24,"identifiers":3166},"1996, The EMBO Journal, 15, 216, 10.1002\u002Fj.1460-2075.1996.tb00352.x",{"doi":3167},"10.1002\u002Fj.1460-2075.1996.tb00352.x",{"id":24,"text":3169,"url":24,"identifiers":3170},"10.1038\u002Fsj.emboj.7600819",{"doi":3169},{"id":24,"text":3172,"url":24,"identifiers":3173},"10.1080\u002F10715760500043132",{"doi":3172},{"id":24,"text":3175,"url":24,"identifiers":3176},"10.1158\u002F0008-5472.CAN-04-2744",{"doi":3175},{"id":24,"text":3178,"url":24,"identifiers":3179},"10.1074\u002Fjbc.m109.002121",{"doi":3178},{"id":24,"text":3181,"url":24,"identifiers":3182},"10.1016\u002Fj.canlet.2008.02.031",{"doi":3181},{"id":24,"text":3184,"url":24,"identifiers":3185},"10.1038\u002Fnchembio.85",{"doi":3184},{"id":24,"text":3187,"url":24,"identifiers":3188},"10.1096\u002Ffj.02-0752rev",{"doi":3187},{"id":24,"text":3190,"url":24,"identifiers":3191},"10.1093\u002Fcarcin\u002F21.3.361",{"doi":3190},{"id":24,"text":3193,"url":24,"identifiers":3194},"10.1007\u002Fs00109-010-0678-2",{"doi":3193},{"id":24,"text":3196,"url":24,"identifiers":3197},"10.1016\u002Fj.stem.2012.10.002",{"doi":3196},{"id":24,"text":3199,"url":24,"identifiers":3200},"10.1002\u002Fjcp.20641",{"doi":3199},{"id":24,"text":3202,"url":24,"identifiers":3203},"10.1016\u002Fj.arr.2012.10.004",{"doi":3202},{"id":24,"text":3205,"url":24,"identifiers":3206},"10.1038\u002Fnature07733",{"doi":3205},{"id":24,"text":3208,"url":24,"identifiers":3209},"10.1016\u002Fj.canlet.2011.10.012",{"doi":3208},{"id":24,"text":3211,"url":24,"identifiers":3212},"10.1007\u002Fs12015-010-9122-9",{"doi":3211},{"id":24,"text":3214,"url":24,"identifiers":3215},"10.1002\u002Fijc.25944",{"doi":3214},{"id":24,"text":2113,"url":24,"identifiers":3217},{"doi":2113},{"id":24,"text":3219,"url":24,"identifiers":3220},"10.1038\u002Fsj.bjc.6605551",{"doi":3219},{"id":24,"text":3222,"url":24,"identifiers":3223},"10.1007\u002Fs13277-013-1561-x",{"doi":3222},{"id":24,"text":3225,"url":24,"identifiers":3226},"10.1186\u002Fbcr2773",{"doi":3225},{"id":24,"text":3228,"url":24,"identifiers":3229},"10.1371\u002Fjournal.pone.0030905",{"doi":3228},{"id":24,"text":3231,"url":24,"identifiers":3232},"10.7150\u002Fijms.5407",{"doi":3231},{"id":24,"text":3234,"url":24,"identifiers":3235},"10.1371\u002Fjournal.pone.0016195",{"doi":3234},{"id":24,"text":3237,"url":24,"identifiers":3238},"10.1158\u002F1078-0432.CCR-11-3114",{"doi":3237},{"id":24,"text":3240,"url":24,"identifiers":3241},"10.1038\u002Fnature04871",{"doi":3240},{"id":24,"text":3243,"url":24,"identifiers":3244},"10.1038\u002Fnrc2540",{"doi":3243},{"id":24,"text":3246,"url":24,"identifiers":3247},"10.1002\u002Fjcp.21537",{"doi":3246},{"id":24,"text":925,"url":24,"identifiers":3249},{"doi":925},{"id":24,"text":3251,"url":24,"identifiers":3252},"10.1016\u002Fj.drup.2011.03.001",{"doi":3251},{"id":24,"text":3254,"url":24,"identifiers":3255},"10.1038\u002Fsrep03793",{"doi":3254},{"id":24,"text":3257,"url":24,"identifiers":3258},"10.1073\u002Fpnas.0907357106",{"doi":3257},{"id":24,"text":3260,"url":24,"identifiers":3261},"10.1016\u002Fj.ccr.2008.10.016",{"doi":3260},{"id":24,"text":3263,"url":24,"identifiers":3264},"10.1038\u002Fng1266",{"doi":3263},{"id":24,"text":3266,"url":24,"identifiers":3267},"10.1016\u002Fj.ccr.2006.08.026",{"doi":3266},{"id":24,"text":3269,"url":24,"identifiers":3270},"10.1016\u002Fj.ccr.2009.03.018",{"doi":3269},{"id":24,"text":3272,"url":24,"identifiers":3273},"2012, International Journal of Oncology, 40, 71",{},{"id":24,"text":3275,"url":24,"identifiers":3276},"10.1016\u002Fj.tibs.2012.06.004",{"doi":3275},{"id":24,"text":3278,"url":24,"identifiers":3279},"10.1158\u002F0008-5472.can-10-4142",{"doi":3278},{"id":24,"text":3281,"url":24,"identifiers":3282},"10.1016\u002Fj.ccr.2011.11.017",{"doi":3281},{"id":24,"text":3284,"url":24,"identifiers":3285},"10.1038\u002Fbjc.2011.159",{"doi":3284},{"id":24,"text":3287,"url":24,"identifiers":3288},"10.1073\u002Fpnas.1102454108",{"doi":3287},{"id":24,"text":3290,"url":24,"identifiers":3291},"10.1158\u002F0008-5472.CAN-07-5779",{"doi":3290},{"id":24,"text":3293,"url":24,"identifiers":3294},"10.1038\u002Fnature10694",{"doi":3293},{"id":24,"text":3296,"url":24,"identifiers":3297},"10.1016\u002Fj.cell.2011.04.029",{"doi":3296},{"id":24,"text":3299,"url":24,"identifiers":3300},"10.1038\u002Fnature11344",{"doi":3299},{"id":24,"text":3302,"url":24,"identifiers":3303},"10.1158\u002F0008-5472.CAN-10-3320",{"doi":3302},{"id":24,"text":3305,"url":24,"identifiers":3306},"10.1371\u002Fjournal.pone.0044078",{"doi":3305},{"id":24,"text":3308,"url":24,"identifiers":3309},"10.1016\u002Fj.canlet.2007.09.012",{"doi":3308},{"id":24,"text":3311,"url":24,"identifiers":3312},"10.1080\u002F10739680802095964",{"doi":3311},{"id":24,"text":3314,"url":24,"identifiers":3315},"10.4161\u002Fcc.8.20.9701",{"doi":3314},{"id":24,"text":3317,"url":24,"identifiers":3318},"10.1182\u002Fblood-2006-08-039073",{"doi":3317},{"id":24,"text":3320,"url":24,"identifiers":3321},"10.1038\u002Fnature04496",{"doi":3320},{"id":24,"text":3323,"url":24,"identifiers":3324},"10.1158\u002F0008-5472.can-05-2018",{"doi":3323},{"id":24,"text":3326,"url":24,"identifiers":3327},"10.1038\u002Fnature03128",{"doi":3326},{"id":24,"text":3329,"url":24,"identifiers":3330},"10.3390\u002Fcancers3022274",{"doi":3329},{"id":24,"text":3332,"url":24,"identifiers":3333},"10.1172\u002FJCI65416",{"doi":3332},{"id":24,"text":3335,"url":24,"identifiers":3336},"2014, The American Journal of Cancer Research, 4, 29",{},{"id":24,"text":3338,"url":24,"identifiers":3339},"10.1093\u002Fjnci\u002F94.13.1020",{"doi":3338},{"id":24,"text":3341,"url":24,"identifiers":3342},"10.1245\u002Fs10434-011-2040-5",{"doi":3341},{"id":24,"text":3344,"url":24,"identifiers":3345},"10.1172\u002Fjci42550",{"doi":3344},{"id":24,"text":3347,"url":24,"identifiers":3348},"10.1016\u002Fj.copbio.2007.10.007",{"doi":3347},{"id":24,"text":3350,"url":24,"identifiers":3351},"10.1038\u002Fnrc3023",{"doi":3350},{"id":24,"text":3353,"url":24,"identifiers":3354},"10.1146\u002Fannurev.cellbio.22.010305.104154",{"doi":3353},{"id":24,"text":3356,"url":24,"identifiers":3357},"10.1073\u002Fpnas.0530291100",{"doi":3356},{"id":24,"text":3359,"url":24,"identifiers":3360},"10.1073\u002Fpnas.0610117104",{"doi":3359},{"id":24,"text":3362,"url":24,"identifiers":3363},"10.1016\u002Fj.stem.2007.06.002",{"doi":3362},{"id":24,"text":3365,"url":24,"identifiers":3366},"10.1073\u002Fpnas.0703478104",{"doi":3365},{"id":24,"text":3368,"url":24,"identifiers":3369},"10.1093\u002Fcarcin\u002Fbgt402",{"doi":3368},{"id":24,"text":3371,"url":24,"identifiers":3372},"10.1038\u002Fonc.2012.638",{"doi":3371},{"id":24,"text":3374,"url":24,"identifiers":3375},"10.1038\u002Fnm0797-730",{"doi":3374},{"id":24,"text":3377,"url":24,"identifiers":3378},"10.1038\u002Fnm1483",{"doi":3377},{"id":24,"text":3380,"url":24,"identifiers":3381},"10.1016\u002Fj.stem.2009.04.018",{"doi":3380},{"id":24,"text":3383,"url":24,"identifiers":3384},"10.1016\u002Fj.cell.2009.05.045",{"doi":3383},{"id":24,"text":3386,"url":24,"identifiers":3387},"10.1038\u002Fsj.leu.2401903",{"doi":3386},{"id":24,"text":3389,"url":24,"identifiers":3390},"10.1182\u002Fblood-2004-03-0901",{"doi":3389},{"id":24,"text":3392,"url":24,"identifiers":3393},"10.1080\u002F07357900801941845",{"doi":3392},{"id":24,"text":3395,"url":24,"identifiers":3396},"10.1002\u002Fstem.92",{"doi":3395},{"id":24,"text":3398,"url":24,"identifiers":3399},"10.1073\u002Fpnas.0906549106",{"doi":3398},{"id":24,"text":3401,"url":24,"identifiers":3402},"10.1016\u002Fj.stem.2007.08.014",{"doi":3401},{"id":24,"text":3404,"url":24,"identifiers":3405},"10.1016\u002Fj.yexcr.2007.03.006",{"doi":3404},{"id":24,"text":3407,"url":24,"identifiers":3408},"10.1158\u002F0008-5472.can-09-3619",{"doi":3407},{"id":24,"text":3410,"url":24,"identifiers":3411},"10.1111\u002Fj.1365-2613.2010.00747.x",{"doi":3410},{"id":24,"text":3413,"url":24,"identifiers":3414},"10.1038\u002Fcgt.2011.58",{"doi":3413},{"id":24,"text":3416,"url":24,"identifiers":3417},"10.1186\u002F1471-2407-12-48",{"doi":3416},{"id":24,"text":3419,"url":24,"identifiers":3420},"10.1038\u002Fnature05384",{"doi":3419},{"id":24,"text":3422,"url":24,"identifiers":3423},"2010, Oncotarget, 1, 387, 10.18632\u002Foncotarget.172",{"doi":3424},"10.18632\u002Foncotarget.172",{"id":24,"text":3426,"url":24,"identifiers":3427},"10.1038\u002Fnature05372",{"doi":3426},{"id":24,"text":3429,"url":24,"identifiers":3430},"10.1158\u002F0008-5472.CAN-08-4418",{"doi":3429},{"id":24,"text":3432,"url":24,"identifiers":3433},"10.1038\u002Fnature07602",{"doi":3432},{"id":24,"text":3435,"url":24,"identifiers":3436},"10.1158\u002F1078-0432.CCR-05-2852",{"doi":3435},{"id":24,"text":3438,"url":24,"identifiers":3439},"10.1016\u002Fj.radonc.2013.03.027",{"doi":3438},{"id":24,"text":3441,"url":24,"identifiers":3442},"10.1158\u002F0008-5472.can-12-2991",{"doi":3441},{"id":24,"text":3444,"url":24,"identifiers":3445},"10.4161\u002Fcbt.10.11.13664",{"doi":3444},{"id":24,"text":3447,"url":24,"identifiers":3448},"10.1002\u002Fijc.25519",{"doi":3447},{"id":24,"text":3450,"url":24,"identifiers":3451},"10.1038\u002Fcr.2011.109",{"doi":3450},{"id":24,"text":3453,"url":24,"identifiers":3454},"10.1038\u002Fonc.2011.282",{"doi":3453},{"id":24,"text":3456,"url":24,"identifiers":3457},"10.1227\u002F01.NEU.0000368393.45935.46",{"doi":3456},{"id":24,"text":3459,"url":24,"identifiers":3460},"10.1007\u002Fs00401-006-0063-y",{"doi":3459},{"id":24,"text":3462,"url":24,"identifiers":3463},"10.1016\u002Fj.stem.2009.03.003",{"doi":3462},{"id":24,"text":3465,"url":24,"identifiers":3466},"10.1111\u002Fj.1750-3639.2009.00269.x",{"doi":3465},{"id":24,"text":3468,"url":24,"identifiers":3469},"10.1016\u002Fj.ccr.2010.10.023",{"doi":3468},{"id":24,"text":3471,"url":24,"identifiers":3472},"10.1016\u002Fj.bbrc.2009.05.048",{"doi":3471},{"id":24,"text":3474,"url":24,"identifiers":3475},"10.1016\u002Fj.ccr.2008.01.013",{"doi":3474},{"id":24,"text":3477,"url":24,"identifiers":3478},"10.1002\u002Fijc.24868",{"doi":3477},{"id":24,"text":3480,"url":24,"identifiers":3481},"10.1016\u002Fj.jhep.2009.10.026",{"doi":3480},{"id":24,"text":3483,"url":24,"identifiers":3484},"10.1111\u002Fj.1349-7006.2010.01661.x",{"doi":3483},{"id":24,"text":3486,"url":24,"identifiers":3487},"10.1038\u002Fsj.cdd.4402283",{"doi":3486},{"id":24,"text":3489,"url":24,"identifiers":3490},"10.1371\u002Fjournal.pone.0014062",{"doi":3489},{"id":24,"text":3492,"url":24,"identifiers":3493},"10.1038\u002Fsj.bjc.6605668",{"doi":3492},{"id":24,"text":3495,"url":24,"identifiers":3496},"10.1016\u002Fj.cell.2011.11.050",{"doi":3495},{"id":24,"text":3498,"url":24,"identifiers":3499},"10.1038\u002Fnature09161",{"doi":3498},{"id":24,"text":3501,"url":24,"identifiers":3502},"10.1158\u002F0008-5472.can-05-1343",{"doi":3501},{"id":24,"text":3504,"url":24,"identifiers":3505},"10.1016\u002Fj.ccr.2010.10.012",{"doi":3504},{"id":24,"text":3507,"url":24,"identifiers":3508},"10.1016\u002Fj.cell.2010.04.020",{"doi":3507},{"id":24,"text":3510,"url":24,"identifiers":3511},"10.1038\u002Fnature06489",{"doi":3510},{"id":24,"text":3513,"url":24,"identifiers":3514},"10.1016\u002Fj.arcmed.2011.01.007",{"doi":3513},{"id":24,"text":3516,"url":24,"identifiers":3517},"10.1016\u002Fj.canlet.2012.11.046",{"doi":3516},{"id":24,"text":3519,"url":24,"identifiers":3520},"10.3892\u002For.2013.2408",{"doi":3519},{"id":24,"text":3522,"url":24,"identifiers":3523},"10.1016\u002Fj.canlet.2009.08.010",{"doi":3522},{"id":24,"text":3525,"url":24,"identifiers":3526},"10.1016\u002Fj.oraloncology.2013.04.012",{"doi":3525},{"id":24,"text":3528,"url":24,"identifiers":3529},"10.1593\u002Fneo.05394",{"doi":3528},{"id":24,"text":3531,"url":24,"identifiers":3532},"10.1158\u002F0008-5472.CAN-09-3463",{"doi":3531},{"id":24,"text":3534,"url":24,"identifiers":3535},"10.1186\u002F1471-2407-8-300",{"doi":3534},{"id":24,"text":3537,"url":24,"identifiers":3538},"10.1371\u002Fjournal.pone.0041401",{"doi":3537},{"id":24,"text":3540,"url":24,"identifiers":3541},"10.1002\u002Fstem.236",{"doi":3540},{"id":24,"text":3543,"url":24,"identifiers":3544},"10.1158\u002F0008-5472.can-08-0364",{"doi":3543},{"id":24,"text":3546,"url":24,"identifiers":3547},"10.1158\u002F1078-0432.CCR-12-1045",{"doi":3546},{"id":24,"text":3549,"url":24,"identifiers":3550},"10.1073\u002Fpnas.1120733109",{"doi":3549},{"id":24,"text":3552,"url":24,"identifiers":3553},"10.1016\u002Fj.yexmp.2011.06.005",{"doi":3552},{"id":24,"text":3555,"url":24,"identifiers":3556},"2009, Identification of human pancreatic cancer stem cells, 568, 161, 10.1007\u002F978-1-59745-280-9_10",{"doi":3557},"10.1007\u002F978-1-59745-280-9_10",{"id":24,"text":3559,"url":24,"identifiers":3560},"10.1073\u002Fpnas.0502320102",{"doi":3559},{"id":24,"text":3562,"url":24,"identifiers":3563},"10.1073\u002Fpnas.95.4.1735",{"doi":3562},{"id":24,"text":3565,"url":24,"identifiers":3566},"10.1186\u002F1471-2490-7-3",{"doi":3565},{"id":24,"text":3568,"url":24,"identifiers":3569},"10.1186\u002F1471-2407-6-195",{"doi":3568},{"id":24,"text":3571,"url":24,"identifiers":3572},"10.1038\u002Fnature06835",{"doi":3571},{"id":24,"text":3574,"url":24,"identifiers":3575},"10.1073\u002Fpnas.1107807108",{"doi":3574},{"id":24,"text":3577,"url":24,"identifiers":3578},"10.1002\u002Fpath.4271",{"doi":3577},{"id":24,"text":3580,"url":24,"identifiers":3581},"10.1016\u002Fj.stem.2012.12.013",{"doi":3580},{"id":24,"text":3583,"url":24,"identifiers":3584},"10.1038\u002Flabinvest.2013.129",{"doi":3583},{"id":24,"text":3586,"url":24,"identifiers":3587},"10.1038\u002Fnrc2981",{"doi":3586},{"id":24,"text":982,"url":24,"identifiers":3589},{"doi":982},{"id":24,"text":3591,"url":24,"identifiers":3592},"10.1038\u002Fnature07016",{"doi":3591},{"id":24,"text":3594,"url":24,"identifiers":3595},"10.1016\u002Fs1734-1140(09)70018-0",{"doi":3594},{"id":24,"text":1378,"url":24,"identifiers":3597},{"doi":1378},{"id":24,"text":3599,"url":24,"identifiers":3600},"10.1158\u002F0008-5472.can-09-3950",{"doi":3599},{"id":24,"text":3602,"url":24,"identifiers":3603},"10.3109\u002F10715762.2011.645207",{"doi":3602},{"id":24,"text":3605,"url":24,"identifiers":3606},"10.1126\u002Fscience.1231677",{"doi":3605},{"id":24,"text":3608,"url":24,"identifiers":3609},"10.1126\u002Fscience.1234769",{"doi":3608},{"id":24,"text":3611,"url":24,"identifiers":3612},"10.1093\u002Fjnci\u002F94.23.1745",{"doi":3611},{"id":24,"text":3614,"url":24,"identifiers":3615},"1982, The Journal of Biological Chemistry, 257, 13704, 10.1016\u002FS0021-9258(18)33504-X",{"doi":3616},"10.1016\u002FS0021-9258(18)33504-X",{"id":24,"text":3618,"url":24,"identifiers":3619},"2010, Current Oncology, 17, 9, 10.3747\u002Fco.v17i3.485",{"doi":3620},"10.3747\u002Fco.v17i3.485",{"id":24,"text":3622,"url":24,"identifiers":3623},"10.1038\u002Fsj.leu.2402238",{"doi":3622},{"id":24,"text":3625,"url":24,"identifiers":3626},"10.1007\u002Fs10549-011-1889-0",{"doi":3625},{"id":24,"text":3628,"url":24,"identifiers":3629},"10.1006\u002Fbbrc.1999.0472",{"doi":3628},{"id":24,"text":3631,"url":24,"identifiers":3632},"10.1002\u002Fcncr.25489",{"doi":3631},{"id":24,"text":3634,"url":24,"identifiers":3635},"10.1016\u002Fj.cmet.2011.12.009",{"doi":3634},{"id":24,"text":3637,"url":24,"identifiers":3638},"10.1016\u002Fj.freeradbiomed.2006.12.021",{"doi":3637},{"id":24,"text":3640,"url":24,"identifiers":3641},"10.1182\u002Fblood-2004-10-4135",{"doi":3640},{"id":24,"text":3643,"url":24,"identifiers":3644},"10.1006\u002Fexcr.2000.4838",{"doi":3643},{"id":24,"text":3646,"url":24,"identifiers":3647},"10.1177\u002F1534735404270335",{"doi":3646},{"id":24,"text":3649,"url":24,"identifiers":3650},"10.5402\u002F2012\u002F137289",{"doi":3649},{"id":24,"text":976,"url":24,"identifiers":3652},{"doi":976},{"id":24,"text":3654,"url":24,"identifiers":3655},"10.1016\u002Fj.bbrc.2007.11.039",{"doi":3654},{"id":24,"text":3657,"url":24,"identifiers":3658},"10.1016\u002Fj.freeradbiomed.2012.04.033",{"doi":3657},{"id":24,"text":3660,"url":24,"identifiers":3661},"10.1016\u002Fj.freeradbiomed.2009.11.005",{"doi":3660},{"id":24,"text":3663,"url":24,"identifiers":3664},"10.1038\u002Fnature05236",{"doi":3663},{"id":24,"text":3666,"url":24,"identifiers":3667},"10.1158\u002F1541-7786.MCR-08-0409",{"doi":3666},{"id":24,"text":3669,"url":24,"identifiers":3670},"10.1158\u002F1078-0432.ccr-09-0263",{"doi":3669},{"id":24,"text":3672,"url":24,"identifiers":3673},"10.1371\u002Fjournal.pone.0050423",{"doi":3672},{"id":24,"text":3675,"url":24,"identifiers":3676},"10.3892\u002Fetm.2012.591",{"doi":3675},{"id":24,"text":3678,"url":24,"identifiers":3679},"10.1371\u002Fjournal.pone.0048175",{"doi":3678},{"id":24,"text":3681,"url":24,"identifiers":3682},"10.1371\u002Fjournal.pone.0031579",{"doi":3681},{"id":24,"text":3684,"url":24,"identifiers":3685},"10.1021\u002Fjf301981n",{"doi":3684},{"id":24,"text":3687,"url":24,"identifiers":3688},"10.2174\u002F0929867013373084",{"doi":3687},{"id":24,"text":3690,"url":24,"identifiers":3691},"2008, International Journal of Cancer, 123, 1227, 10.1002\u002Fijc.23754",{"doi":1273},{"id":24,"text":3693,"url":24,"identifiers":3694},"10.1093\u002Fjnci\u002Fdjs277",{"doi":3693},{"id":24,"text":3696,"url":24,"identifiers":3697},"10.1056\u002Fnejm199605023341802",{"doi":3696},{"id":24,"text":3699,"url":24,"identifiers":3700},"10.1371\u002Fjournal.pone.0005284",{"doi":3699},{"id":24,"text":3702,"url":24,"identifiers":3703},"10.1016\u002Fj.jnutbio.2012.03.002",{"doi":3702},{"id":3705,"createTime":3706,"updateTime":3706,"relativeEntities":3707,"slug":3708,"properties":3709,"entityType":120,"verifyStatus":121,"verifyTime":3706,"verifyNote":122,"syncStatus":23,"languages":3725,"translateLanguages":24,"viewCount":25,"primaryUrl":3726,"fullTextUrl":24,"authors":3727,"publicationType":220,"publisherRelationship":3778,"citationCount":3801,"citationInfo":3802,"publishDate":3809,"publishYear":3810,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":3811,"isForceReanalyzing":395},"0fc1d961-4f5e-404f-a50c-a60b0c1c6833","2024-09-30T22:18:02.481+00:00",[],"The-Essential-Element-Manganese-Oxidative-Stress-and-Metabolic-Diseases-Links-and-Interactions",{"mag":3710,"keywords":3712,"pmc":3713,"openalex":3715,"abstract":3717,"title":3719,"pm":3721,"doi":3723},{"VOID":3711},"2795787434",{},{"VOID":3714},"5907490",{"VOID":3716},"W2795787434",{"EN":3718},"\u003Cjats:p>Manganese (Mn) is an essential element that is involved in the synthesis and activation of many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In addition, Mn is one of the required components for Mn superoxide dismutase (MnSOD) that is mainly responsible for scavenging reactive oxygen species (ROS) in mitochondrial oxidative stress. Both Mn deficiency and intoxication are associated with adverse metabolic and neuropsychiatric effects. Over the past few decades, the prevalence of metabolic diseases, including type 2 diabetes mellitus (T2MD), obesity, insulin resistance, atherosclerosis, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and hepatic steatosis, has increased dramatically. Previous studies have found that ROS generation, oxidative stress, and inflammation are critical for the pathogenesis of metabolic diseases. In addition, deficiency in dietary Mn as well as excessive Mn exposure could increase ROS generation and result in further oxidative stress. However, the relationship between Mn and metabolic diseases is not clear. In this review, we provide insights into the role Mn plays in the prevention and development of metabolic diseases.\u003C\u002Fjats:p>",{"EN":3720},"The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions",{"VOID":3722},"29849912",{"VOID":3724},"10.1155\u002F2018\u002F7580707",[124],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1155\u002F2018\u002F7580707",[3728,3761],{"id":3729,"sortIndex":169,"researcher":24,"roles":3730,"affiliations":3731,"properties":3754},"0aaa9f5b-dc52-4df2-9987-f46aa2bbb823",[],[3732,3743],{"id":3733,"sortIndex":169,"affiliation":3734,"properties":24},"d3a636f6-a848-47f7-9536-2b558aa7b874",{"id":3735,"createTime":3736,"updateTime":3737,"relativeEntities":3738,"slug":3739,"properties":3740,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5fb531f9-2043-425e-b3b5-21fc0c2e333d","2024-02-11T12:46:11.469+00:00","2024-09-30T22:18:02.498+00:00",[],"Department-of-Occupational-Health-and-Environmental-Health-School-of-Public-Health-Guangxi-Medical-University-Nanning-Guangxi-China",{"title":3741},{"VI":3742},"Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China",{"id":3744,"sortIndex":25,"affiliation":3745,"properties":24},"5f7fd879-0958-4bde-ad3b-bc0b3a18eec5",{"id":3746,"createTime":3747,"updateTime":3748,"relativeEntities":3749,"slug":3750,"properties":3751,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"bbd586de-0c0b-4545-9e5e-cd0632669ef9","2024-01-01T15:48:43.296+00:00","2024-09-30T22:18:02.508+00:00",[],"Center-for-Genomic-and-Personalized-Medicine-Guangxi-Medical-University-Nanning-Guangxi-China",{"title":3752},{"VI":3753},"Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China",{"openalex":3755,"orcid":3757,"title":3759},{"VOID":3756},"A5101804593",{"VOID":3758},"https:\u002F\u002Forcid.org\u002F0000-0001-9866-7724",{"EN":3760},"Xiaobo Yang",{"id":3762,"sortIndex":25,"researcher":24,"roles":3763,"affiliations":3764,"properties":3771},"5b2db1ea-62d2-4598-9749-978f33fed298",[],[3765],{"id":3766,"sortIndex":25,"affiliation":3767,"properties":24},"862ac005-d300-4f80-8c61-42286e91365e",{"id":3735,"createTime":3736,"updateTime":3737,"relativeEntities":3768,"slug":3739,"properties":3769,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":3770},{"VI":3742},{"openalex":3772,"orcid":3774,"title":3776},{"VOID":3773},"A5043662420",{"VOID":3775},"https:\u002F\u002Forcid.org\u002F0000-0001-8155-5830",{"EN":3777},"Longman Li",{"url":24,"publisher":3779,"properties":3797},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":3780,"slug":10,"properties":3781,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":3787,"manageAffiliations":3788,"indexDatabases":3789,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":3782,"issn":3783,"introduce":3784,"eissn":3785,"title":3786},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[3790],{"id":73,"indexDatabase":3791,"url":86,"indexYears":87,"academicFieldIds":3796,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":3792,"label":3793,"description":3794,"key":83,"publicationTags":3795,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":3798,"issue":3800},{"VOID":3799},"2018",{"VOID":836},398,{"total":3801,"publishYear":24,"statisticByYear":3803},{"2018":469,"2019":840,"2020":3804,"2021":3805,"2022":3806,"2023":3807,"2024":3808},50,76,86,98,63,"2018-01-01",2018,[3812,3815,3818,3821,3824,3827,3830,3833,3836,3839,3842,3845,3848,3851,3854,3857,3860,3863,3866,3869,3872,3875,3878,3881,3884,3887,3890,3893,3896,3899,3902,3905,3908,3911,3914,3917,3920,3923,3926,3929,3932,3935,3938,3941,3944,3947,3950,3953,3956,3959,3962,3965,3968,3971,3974,3977,3980,3983,3986,3989,3992,3995,3998,4001,4004,4007,4010,4013,4016,4019,4022,4025,4028,4031,4034,4037,4040,4043,4046,4049,4052,4055,4058,4061,4064,4067,4070,4073,4076,4079,4082,4085,4088,4091,4094,4097,4100,4103,4106,4109,4112,4115,4118,4121,4124,4127,4130,4133,4136,4139,4142,4145,4148,4151,4154,4157,4160,4163,4166,4169,4172,4175,4178,4181],{"id":24,"text":3813,"url":24,"identifiers":3814},"10.1186\u002F1476-069X-12-30",{"doi":3813},{"id":24,"text":3816,"url":24,"identifiers":3817},"10.1016\u002Fj.mam.2005.07.003",{"doi":3816},{"id":24,"text":3819,"url":24,"identifiers":3820},"10.1186\u002F1472-6823-14-24",{"doi":3819},{"id":24,"text":3822,"url":24,"identifiers":3823},"10.1016\u002Fj.semcdb.2015.04.007",{"doi":3822},{"id":24,"text":3825,"url":24,"identifiers":3826},"10.3390\u002Fijerph120403944",{"doi":3825},{"id":24,"text":3828,"url":24,"identifiers":3829},"10.1177\u002F1479164118755044",{"doi":3828},{"id":24,"text":3831,"url":24,"identifiers":3832},"10.1016\u002Fj.abb.2015.04.005",{"doi":3831},{"id":24,"text":3834,"url":24,"identifiers":3835},"10.1111\u002Fj.1749-6632.2010.05798.x",{"doi":3834},{"id":24,"text":3837,"url":24,"identifiers":3838},"10.1161\u002F01.RES.82.12.1289",{"doi":3837},{"id":24,"text":3840,"url":24,"identifiers":3841},"10.1016\u002Fj.antiviral.2014.09.010",{"doi":3840},{"id":24,"text":3843,"url":24,"identifiers":3844},"10.1016\u002FS1262-3636(07)70098-8",{"doi":3843},{"id":24,"text":3846,"url":24,"identifiers":3847},"10.1301\u002F002966402320387224",{"doi":3846},{"id":24,"text":3849,"url":24,"identifiers":3850},"10.1152\u002Fajpgi.1983.245.5.G628",{"doi":3849},{"id":24,"text":3852,"url":24,"identifiers":3853},"10.1016\u002Fj.bbadis.2014.03.010",{"doi":3852},{"id":24,"text":3855,"url":24,"identifiers":3856},"10.1016\u002Fj.freeradbiomed.2009.01.022",{"doi":3855},{"id":24,"text":3858,"url":24,"identifiers":3859},"10.3390\u002Fantiox7020025",{"doi":3858},{"id":24,"text":3861,"url":24,"identifiers":3862},"10.1210\u002Fen.2006-0998",{"doi":3861},{"id":24,"text":3864,"url":24,"identifiers":3865},"Greger J. L., 1999, Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers, Neurotoxicology, 20, 205",{},{"id":24,"text":3867,"url":24,"identifiers":3868},"10.1111\u002Fj.1753-4887.1988.tb05360.x",{"doi":3867},{"id":24,"text":3870,"url":24,"identifiers":3871},"10.1016\u002FS0361-9230(01)00456-7",{"doi":3870},{"id":24,"text":3873,"url":24,"identifiers":3874},"10.1074\u002Fjbc.M402096200",{"doi":3873},{"id":24,"text":3876,"url":24,"identifiers":3877},"10.1096\u002Ffj.10-163964",{"doi":3876},{"id":24,"text":3879,"url":24,"identifiers":3880},"10.1080\u002F13547500210146740",{"doi":3879},{"id":24,"text":3882,"url":24,"identifiers":3883},"10.1038\u002Foby.2007.628",{"doi":3882},{"id":24,"text":3885,"url":24,"identifiers":3886},"10.1210\u002Fer.2008-0024",{"doi":3885},{"id":24,"text":3888,"url":24,"identifiers":3889},"10.1172\u002FJCI25102",{"doi":3888},{"id":24,"text":3891,"url":24,"identifiers":3892},"10.1172\u002FJCI21625",{"doi":3891},{"id":24,"text":3894,"url":24,"identifiers":3895},"10.1161\u002F01.ATV.0000058402.34138.11",{"doi":3894},{"id":24,"text":3897,"url":24,"identifiers":3898},"10.1111\u002Fj.1600-0676.1998.tb00120.x",{"doi":3897},{"id":24,"text":3900,"url":24,"identifiers":3901},"10.1017\u002FS0007114516002580",{"doi":3900},{"id":24,"text":3903,"url":24,"identifiers":3904},"10.1007\u002Fs12011-013-9852-z",{"doi":3903},{"id":24,"text":3906,"url":24,"identifiers":3907},"10.6133\u002Fapjcn.2013.22.1.06",{"doi":3906},{"id":24,"text":3909,"url":24,"identifiers":3910},"10.1186\u002F1475-2840-12-9",{"doi":3909},{"id":24,"text":3912,"url":24,"identifiers":3913},"10.1038\u002F414782a",{"doi":3912},{"id":24,"text":3915,"url":24,"identifiers":3916},"10.1161\u002FCIRCRESAHA.110.223545",{"doi":3915},{"id":24,"text":3918,"url":24,"identifiers":3919},"10.1038\u002F35008121",{"doi":3918},{"id":24,"text":3921,"url":24,"identifiers":3922},"10.1016\u002Fj.molmet.2014.02.001",{"doi":3921},{"id":24,"text":3924,"url":24,"identifiers":3925},"10.1126\u002Fscience.1104343",{"doi":3924},{"id":24,"text":3927,"url":24,"identifiers":3928},"10.1172\u002FJCI25151",{"doi":3927},{"id":24,"text":3930,"url":24,"identifiers":3931},"10.1073\u002Fpnas.0902380106",{"doi":3930},{"id":24,"text":3933,"url":24,"identifiers":3934},"10.2337\u002Fdiabetes.55.03.06.db05-1039",{"doi":3933},{"id":24,"text":3936,"url":24,"identifiers":3937},"10.1016\u002Fj.bbrc.2007.12.041",{"doi":3936},{"id":24,"text":3939,"url":24,"identifiers":3940},"10.1016\u002Fj.freeradbiomed.2006.01.012",{"doi":3939},{"id":24,"text":3942,"url":24,"identifiers":3943},"10.1016\u002Fj.expneurol.2007.07.017",{"doi":3942},{"id":24,"text":3945,"url":24,"identifiers":3946},"10.2337\u002Fdiabetes.52.2.387",{"doi":3945},{"id":24,"text":3948,"url":24,"identifiers":3949},"10.1016\u002Fj.nut.2012.11.005",{"doi":3948},{"id":24,"text":3951,"url":24,"identifiers":3952},"10.1210\u002Fen.2012-1445",{"doi":3951},{"id":24,"text":3954,"url":24,"identifiers":3955},"10.1007\u002Fs11010-016-2931-7",{"doi":3954},{"id":24,"text":3957,"url":24,"identifiers":3958},"10.1074\u002Fjbc.M112.447805",{"doi":3957},{"id":24,"text":3960,"url":24,"identifiers":3961},"10.1089\u002Fars.2012.5167",{"doi":3960},{"id":24,"text":3963,"url":24,"identifiers":3964},"10.1016\u002F0378-4274(85)90106-7",{"doi":3963},{"id":24,"text":3966,"url":24,"identifiers":3967},"Hurley L. S., 1984, Manganese deficiency and toxicity: effects on carbohydrate metabolism in the rat, Neurotoxicology, 5, 97",{},{"id":24,"text":3969,"url":24,"identifiers":3970},"Mousavi Z., 2016, Effects of subcutaneous injection MnO2 micro- and nanoparticles on blood glucose level and lipid profile in rat, Iranian Journal of Medical Sciences, 41, 518",{},{"id":24,"text":3972,"url":24,"identifiers":3973},"10.1016\u002Fj.diabres.2010.12.014",{"doi":3972},{"id":24,"text":3975,"url":24,"identifiers":3976},"10.1385\u002FBTER:94:3:193",{"doi":3975},{"id":24,"text":3978,"url":24,"identifiers":3979},"10.1007\u002Fs12011-007-8062-y",{"doi":3978},{"id":24,"text":3981,"url":24,"identifiers":3982},"10.1016\u002Fj.jtemb.2015.10.006",{"doi":3981},{"id":24,"text":3984,"url":24,"identifiers":3985},"10.1007\u002Fs12011-013-9858-6",{"doi":3984},{"id":24,"text":3987,"url":24,"identifiers":3988},"10.1007\u002Fs00404-009-0955-x",{"doi":3987},{"id":24,"text":3990,"url":24,"identifiers":3991},"10.1016\u002Fj.archger.2012.11.002",{"doi":3990},{"id":24,"text":3993,"url":24,"identifiers":3994},"10.1289\u002FEHP176",{"doi":3993},{"id":24,"text":3996,"url":24,"identifiers":3997},"10.1016\u002Fj.envpol.2015.11.046",{"doi":3996},{"id":24,"text":3999,"url":24,"identifiers":4000},"10.1289\u002Fehp.1307563",{"doi":3999},{"id":24,"text":4002,"url":24,"identifiers":4003},"10.1016\u002Fj.cca.2012.10.029",{"doi":4002},{"id":24,"text":4005,"url":24,"identifiers":4006},"10.1385\u002FBTER:79:3:205",{"doi":4005},{"id":24,"text":4008,"url":24,"identifiers":4009},"10.1016\u002Fj.exer.2016.10.020",{"doi":4008},{"id":24,"text":4011,"url":24,"identifiers":4012},"10.1001\u002Fjama.2014.6228",{"doi":4011},{"id":24,"text":4014,"url":24,"identifiers":4015},"10.1159\u002F000458467",{"doi":4014},{"id":24,"text":4017,"url":24,"identifiers":4018},"10.1152\u002Fphysrev.00014.2008",{"doi":4017},{"id":24,"text":4020,"url":24,"identifiers":4021},"10.1007\u002Fs13105-011-0074-6",{"doi":4020},{"id":24,"text":4023,"url":24,"identifiers":4024},"10.1007\u002Fs10495-009-0415-x",{"doi":4023},{"id":24,"text":4026,"url":24,"identifiers":4027},"10.1152\u002Fajpendo.00629.2006",{"doi":4026},{"id":24,"text":4029,"url":24,"identifiers":4030},"10.1152\u002Fajpendo.90921.2008",{"doi":4029},{"id":24,"text":4032,"url":24,"identifiers":4033},"10.1016\u002Fj.nutres.2010.01.003",{"doi":4032},{"id":24,"text":4035,"url":24,"identifiers":4036},"10.1002\u002Foby.20465",{"doi":4035},{"id":24,"text":4038,"url":24,"identifiers":4039},"10.3746\u002Fpnf.2014.19.1.019",{"doi":4038},{"id":24,"text":4041,"url":24,"identifiers":4042},"10.2337\u002Fdb16-0283",{"doi":4041},{"id":24,"text":4044,"url":24,"identifiers":4045},"10.1371\u002Fjournal.pone.0086866",{"doi":4044},{"id":24,"text":4047,"url":24,"identifiers":4048},"10.1002\u002Fhep.20177",{"doi":4047},{"id":24,"text":4050,"url":24,"identifiers":4051},"10.1371\u002Fjournal.pone.0137388",{"doi":4050},{"id":24,"text":4053,"url":24,"identifiers":4054},"10.1038\u002Fnature04634",{"doi":4053},{"id":24,"text":4056,"url":24,"identifiers":4057},"10.1093\u002Fjn\u002F116.8.1432",{"doi":4056},{"id":24,"text":4059,"url":24,"identifiers":4060},"10.1016\u002Fj.scitotenv.2009.11.041",{"doi":4059},{"id":24,"text":4062,"url":24,"identifiers":4063},"10.1007\u002Fs12011-014-0038-0",{"doi":4062},{"id":24,"text":4065,"url":24,"identifiers":4066},"10.1007\u002Fs12011-010-8878-8",{"doi":4065},{"id":24,"text":4068,"url":24,"identifiers":4069},"10.3390\u002Fnu9020104",{"doi":4068},{"id":24,"text":4071,"url":24,"identifiers":4072},"10.1042\u002Fbj20030420",{"doi":4071},{"id":24,"text":4074,"url":24,"identifiers":4075},"10.1056\u002FNEJM199901143400207",{"doi":4074},{"id":24,"text":4077,"url":24,"identifiers":4078},"10.1038\u002F35025203",{"doi":4077},{"id":24,"text":4080,"url":24,"identifiers":4081},"10.1089\u002F152581601750098192",{"doi":4080},{"id":24,"text":4083,"url":24,"identifiers":4084},"10.1074\u002Fjbc.272.37.22975",{"doi":4083},{"id":24,"text":4086,"url":24,"identifiers":4087},"10.1016\u002FS0021-9150(98)00173-7",{"doi":4086},{"id":24,"text":4089,"url":24,"identifiers":4090},"10.3389\u002Ffimmu.2013.00278",{"doi":4089},{"id":24,"text":4092,"url":24,"identifiers":4093},"10.1152\u002Fajpheart.00292.2006",{"doi":4092},{"id":24,"text":4095,"url":24,"identifiers":4096},"10.1161\u002F01.CIR.0000023921.93743.89",{"doi":4095},{"id":24,"text":4098,"url":24,"identifiers":4099},"10.1096\u002Ffasebj.12.6.461",{"doi":4098},{"id":24,"text":4101,"url":24,"identifiers":4102},"10.1038\u002Fsj.bjp.0705354",{"doi":4101},{"id":24,"text":4104,"url":24,"identifiers":4105},"10.1161\u002F01.ATV.0000238347.77590.c9",{"doi":4104},{"id":24,"text":4107,"url":24,"identifiers":4108},"10.1134\u002FS1990750811020090",{"doi":4107},{"id":24,"text":4110,"url":24,"identifiers":4111},"10.1016\u002Fj.vph.2016.07.001",{"doi":4110},{"id":24,"text":4113,"url":24,"identifiers":4114},"10.1007\u002FBF02916613",{"doi":4113},{"id":24,"text":4116,"url":24,"identifiers":4117},"10.1016\u002Fj.heliyon.2015.e00054",{"doi":4116},{"id":24,"text":4119,"url":24,"identifiers":4120},"10.1016\u002Fj.cld.2009.07.009",{"doi":4119},{"id":24,"text":4122,"url":24,"identifiers":4123},"10.1002\u002Fhep.23280",{"doi":4122},{"id":24,"text":4125,"url":24,"identifiers":4126},"10.1056\u002FNEJMra011775",{"doi":4125},{"id":24,"text":4128,"url":24,"identifiers":4129},"10.1016\u002FS0168-8278(03)00460-4",{"doi":4128},{"id":24,"text":4131,"url":24,"identifiers":4132},"10.1152\u002Fajpgi.00426.2001",{"doi":4131},{"id":24,"text":4134,"url":24,"identifiers":4135},"10.1093\u002Ftoxsci\u002F65.2.166",{"doi":4134},{"id":24,"text":4137,"url":24,"identifiers":4138},"10.1055\u002Fs-2001-12927",{"doi":4137},{"id":24,"text":4140,"url":24,"identifiers":4141},"10.6091\u002Fibj.1201.2013",{"doi":4140},{"id":24,"text":4143,"url":24,"identifiers":4144},"10.1007\u002Fs12011-014-0018-4",{"doi":4143},{"id":24,"text":4146,"url":24,"identifiers":4147},"10.1111\u002Fjnc.13170",{"doi":4146},{"id":24,"text":4149,"url":24,"identifiers":4150},"10.1016\u002Fj.neuro.2013.06.002",{"doi":4149},{"id":24,"text":4152,"url":24,"identifiers":4153},"10.1093\u002Ftoxsci\u002Fkfq376",{"doi":4152},{"id":24,"text":4155,"url":24,"identifiers":4156},"10.1016\u002Fj.jtemb.2012.07.002",{"doi":4155},{"id":24,"text":4158,"url":24,"identifiers":4159},"10.1039\u002FC4MT00168K",{"doi":4158},{"id":24,"text":4161,"url":24,"identifiers":4162},"10.1006\u002Fbbrc.1996.1394",{"doi":4161},{"id":24,"text":4164,"url":24,"identifiers":4165},"10.1097\u002F00008571-200303000-00004",{"doi":4164},{"id":24,"text":4167,"url":24,"identifiers":4168},"10.3109\u002F10715762.2013.836275",{"doi":4167},{"id":24,"text":4170,"url":24,"identifiers":4171},"10.1016\u002Fj.jsbmb.2016.04.006",{"doi":4170},{"id":24,"text":4173,"url":24,"identifiers":4174},"10.1179\u002F1351000212Y.0000000008",{"doi":4173},{"id":24,"text":4176,"url":24,"identifiers":4177},"10.1136\u002Fbmjopen-2014-005070",{"doi":4176},{"id":24,"text":4179,"url":24,"identifiers":4180},"10.1371\u002Fjournal.pgen.1006892",{"doi":4179},{"id":24,"text":4182,"url":24,"identifiers":4183},"10.1039\u002FC4MT00292J",{"doi":4182},{"id":4185,"createTime":4186,"updateTime":4186,"relativeEntities":4187,"slug":4188,"properties":4189,"entityType":120,"verifyStatus":121,"verifyTime":4205,"verifyNote":122,"syncStatus":23,"languages":4206,"translateLanguages":24,"viewCount":25,"primaryUrl":4207,"fullTextUrl":24,"authors":4208,"publicationType":220,"publisherRelationship":4306,"citationCount":841,"citationInfo":4329,"publishDate":4331,"publishYear":4332,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":4333,"isForceReanalyzing":395},"cb3e7787-bb81-45fb-9c8f-55e7ec57b631","2024-09-30T22:11:50.333+00:00",[],"Melatonin-Ameliorates-Valproic-Acid-Induced-Neurogenesis-Impairment-The-Role-of-Oxidative-Stress-in-Adult-Rats",{"mag":4190,"keywords":4192,"pmc":4193,"openalex":4195,"abstract":4197,"title":4199,"pm":4201,"doi":4203},{"VOID":4191},"3211870995",{},{"VOID":4194},"8604576",{"VOID":4196},"W3211870995",{"EN":4198},"\u003Cjats:p>\u003Cjats:italic>Background\u003C\u002Fjats:italic>. Valproic acid (anticonvulsant medication) has been found to inhibit histone deacetylase activity and suppress hippocampal neurogenesis, which causes memory impairment in both humans and rodents. The neurohormone melatonin, which regulates mammalian seasonal and circadian physiology, has recently been shown to have neuroprotective properties, counteracting memory impairment associated with VPA‐caused hippocampal neurogenesis reduction. This study is aimed at investigating the molecular mechanisms of melatonin associated with VPA‐induced hippocampal neurogenesis and memory impairment. \u003Cjats:italic>Methods\u003C\u002Fjats:italic>. Male Spraque‐Dawley rats received VPA (300 mg\u002Fkg) twice daily or melatonin (8 mg\u002Fkg\u002Fday) or some rats were given melatonin for 14 days during VPA administration. \u003Cjats:italic>Results\u003C\u002Fjats:italic>. The VPA‐treated rats showed a significant increase in malondialdehyde (MDA) levels in the hippocampus and p21‐positive cells in the subgranular zone (SGZ) of the dentate gyrus (DG) but decreased superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities. Moreover, VPA significantly decreased levels of nestin, Notchl, nuclear factor erythroid 2‐related factor 2 (Nrf2), doublecortin (DCX), sex determining region Y‐box 2 (SOX2), and brain‐derived neurotrophic factor (BDNF). \u003Cjats:italic>Conclusions\u003C\u002Fjats:italic>. We found that melatonin was able to counteract these neurotoxic effects, acting as a neuroprotectant in VPA‐induced memory hippocampal neurogenesis impairment by preventing intracellular oxidative stress and increasing antioxidant activity.\u003C\u002Fjats:p>",{"EN":4200},"Melatonin Ameliorates Valproic Acid‐Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats",{"VOID":4202},"34804374",{"VOID":4204},"10.1155\u002F2021\u002F9997582","2024-09-30T22:11:50.332+00:00",[124],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1155\u002F2021\u002F9997582",[4209,4231,4250,4272,4289],{"id":4210,"sortIndex":151,"researcher":24,"roles":4211,"affiliations":4212,"properties":4224},"77ce94cb-e1c8-41a3-8206-312061be5c6a",[],[4213],{"id":4214,"sortIndex":25,"affiliation":4215,"properties":24},"1033a054-6f11-4000-ac8e-7dc269ac84db",{"id":4216,"createTime":4217,"updateTime":4218,"relativeEntities":4219,"slug":4220,"properties":4221,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"431fda99-3a25-446c-8312-d47234ea0f51","2023-12-06T02:46:39.668+00:00","2024-12-01T12:53:22.308+00:00",[],"Department-of-Anatomy-Faculty-of-Medicine-Khon-Kaen-University-Khon-Kaen-Thailand",{"title":4222},{"VI":4223},"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand",{"openalex":4225,"orcid":4227,"title":4229},{"VOID":4226},"A5072173213",{"VOID":4228},"https:\u002F\u002Forcid.org\u002F0000-0002-8820-5873",{"EN":4230},"Wanassanun Pannangrong",{"id":4232,"sortIndex":129,"researcher":24,"roles":4233,"affiliations":4234,"properties":4245},"3dc75f17-67ba-457d-85a3-a43c04d9d28d",[],[4235],{"id":4236,"sortIndex":25,"affiliation":4237,"properties":24},"073f1f1f-9a30-481b-a4ce-60de42540c3a",{"id":4238,"createTime":4239,"updateTime":4239,"relativeEntities":4240,"slug":4241,"properties":4242,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"90de48d8-e259-4151-8830-bda15bb52151","2024-09-30T22:11:50.367+00:00",[],"School-of-Life-Sciences-Medical-School-Queen-s-Medical-Centre-Nottingham-University-Nottingham-UK",{"title":4243},{"EN":4244},"School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham University, Nottingham, UK",{"openalex":4246,"title":4248},{"VOID":4247},"A5064469661",{"EN":4249},"Peter Wigmore",{"id":4251,"sortIndex":169,"researcher":24,"roles":4252,"affiliations":4253,"properties":4265},"893eb850-c8c7-4a47-b2aa-5acbcfb641f7",[],[4254],{"id":4255,"sortIndex":25,"affiliation":4256,"properties":24},"7a3bf6b2-d9b7-4858-9b6d-1d1828b0b7b4",{"id":4257,"createTime":4258,"updateTime":4259,"relativeEntities":4260,"slug":4261,"properties":4262,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"e32b77f4-b686-43f5-8126-06b4a4fdefff","2024-01-04T10:09:09.763+00:00","2024-09-30T22:11:50.346+00:00",[],"Neurogenesis-Research-Group-Department-of-Anatomy-Faculty-of-Medicine-Khon-Kaen-University-Khon-Kaen-40002-Thailand",{"title":4263},{"VI":4264},"Neurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand",{"openalex":4266,"orcid":4268,"title":4270},{"VOID":4267},"A5042985070",{"VOID":4269},"https:\u002F\u002Forcid.org\u002F0000-0002-6929-7709",{"EN":4271},"Apiwat Sirichoat",{"id":4273,"sortIndex":25,"researcher":24,"roles":4274,"affiliations":4275,"properties":4282},"9bb128c3-ec39-4acb-929c-94923acdc8ec",[],[4276],{"id":4277,"sortIndex":25,"affiliation":4278,"properties":24},"347e4383-d011-4c8c-8184-390b9884a7f1",{"id":4257,"createTime":4258,"updateTime":4259,"relativeEntities":4279,"slug":4261,"properties":4280,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4281},{"VI":4264},{"openalex":4283,"orcid":4285,"title":4287},{"VOID":4284},"A5024343605",{"VOID":4286},"https:\u002F\u002Forcid.org\u002F0000-0002-3226-2713",{"EN":4288},"Anusara Aranarochana",{"id":4290,"sortIndex":204,"researcher":24,"roles":4291,"affiliations":4292,"properties":4299},"654f7e2a-ba60-4985-acf3-a2852ff499c9",[],[4293],{"id":4294,"sortIndex":25,"affiliation":4295,"properties":24},"1af3c445-4d56-40ac-a3fd-f0ba3af4d63c",{"id":4257,"createTime":4258,"updateTime":4259,"relativeEntities":4296,"slug":4261,"properties":4297,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4298},{"VI":4264},{"openalex":4300,"orcid":4302,"title":4304},{"VOID":4301},"A5079907583",{"VOID":4303},"https:\u002F\u002Forcid.org\u002F0000-0002-2872-1542",{"EN":4305},"Jariya Umka Welbat",{"url":24,"publisher":4307,"properties":4325},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":4308,"slug":10,"properties":4309,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":4315,"manageAffiliations":4316,"indexDatabases":4317,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":4310,"issn":4311,"introduce":4312,"eissn":4313,"title":4314},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[4318],{"id":73,"indexDatabase":4319,"url":86,"indexYears":87,"academicFieldIds":4324,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":4320,"label":4321,"description":4322,"key":83,"publicationTags":4323,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":4326,"issue":4328},{"VOID":4327},"2021",{"VOID":836},{"total":841,"publishYear":24,"statisticByYear":4330},{"2022":248,"2023":129,"2024":469},"2021-01-01",2021,[4334,4337,4340,4343,4346,4349,4352,4355,4358,4361,4364,4367,4370,4373,4376,4379,4382,4385,4388,4391,4394,4397,4400,4403,4406,4409,4412,4415,4418,4421,4424,4427,4430,4433,4436,4439,4442,4445,4448,4451,4454,4457,4460,4463,4466,4469,4472,4475,4478,4481,4484,4487,4490,4493,4496,4499,4502,4505,4508,4511,4514,4517,4520,4523,4526],{"id":24,"text":4335,"url":24,"identifiers":4336},"10.1111\u002Fj.1471-4159.2006.03907.x",{"doi":4335},{"id":24,"text":4338,"url":24,"identifiers":4339},"10.1016\u002FS0028-3908(01)00019-3",{"doi":4338},{"id":24,"text":4341,"url":24,"identifiers":4342},"10.3390\u002Fijms141224438",{"doi":4341},{"id":24,"text":4344,"url":24,"identifiers":4345},"10.1016\u002Fj.nbd.2006.03.017",{"doi":4344},{"id":24,"text":4347,"url":24,"identifiers":4348},"10.1016\u002Fj.bbr.2011.07.045",{"doi":4347},{"id":24,"text":4350,"url":24,"identifiers":4351},"10.1016\u002Fj.ejphar.2005.11.049",{"doi":4350},{"id":24,"text":4353,"url":24,"identifiers":4354},"10.1016\u002Fj.neurobiolaging.2009.05.017",{"doi":4353},{"id":24,"text":4356,"url":24,"identifiers":4357},"10.1016\u002Fj.neuroscience.2019.02.022",{"doi":4356},{"id":24,"text":4359,"url":24,"identifiers":4360},"10.1006\u002Fphrs.1999.0603",{"doi":4359},{"id":24,"text":4362,"url":24,"identifiers":4363},"10.1093\u002Ftoxsci\u002Fkfi185",{"doi":4362},{"id":24,"text":4365,"url":24,"identifiers":4366},"10.1016\u002Fj.neuroscience.2012.08.060",{"doi":4365},{"id":24,"text":4368,"url":24,"identifiers":4369},"10.1093\u002Femboj\u002F20.24.6969",{"doi":4368},{"id":24,"text":4371,"url":24,"identifiers":4372},"10.1186\u002F1471-2121-9-66",{"doi":4371},{"id":24,"text":4374,"url":24,"identifiers":4375},"10.1158\u002F1535-7163.MCT-05-0480",{"doi":4374},{"id":24,"text":4377,"url":24,"identifiers":4378},"10.1124\u002Fmol.111.072314",{"doi":4377},{"id":24,"text":4380,"url":24,"identifiers":4381},"10.1034\u002Fj.1600-079X.2002.01873.x",{"doi":4380},{"id":24,"text":4383,"url":24,"identifiers":4384},"10.1111\u002Fj.1600-079X.2006.00407.x",{"doi":4383},{"id":24,"text":4386,"url":24,"identifiers":4387},"Reiter R. J., 2008, Melatonin reduces oxidative\u002Fnitrosative stress due to drugs, toxins, metals, and herbicides, Neuroendocrinology Letters, 29, 609",{},{"id":24,"text":4389,"url":24,"identifiers":4390},"10.1016\u002Fj.pneurobio.2009.10.019",{"doi":4389},{"id":24,"text":4392,"url":24,"identifiers":4393},"10.1111\u002Fj.1600-079X.2007.00435.x",{"doi":4392},{"id":24,"text":4395,"url":24,"identifiers":4396},"10.1038\u002Fnpp.2009.46",{"doi":4395},{"id":24,"text":4398,"url":24,"identifiers":4399},"10.1016\u002Fj.neuroscience.2009.11.073",{"doi":4398},{"id":24,"text":4401,"url":24,"identifiers":4402},"10.1016\u002F0143-4004(88)90001-X",{"doi":4401},{"id":24,"text":4404,"url":24,"identifiers":4405},"10.3390\u002Fnu10081053",{"doi":4404},{"id":24,"text":4407,"url":24,"identifiers":4408},"10.1590\u002FS0100-40422009000100032",{"doi":4407},{"id":24,"text":4410,"url":24,"identifiers":4411},"10.1016\u002FS0021-9258(19)50881-X",{"doi":4410},{"id":24,"text":4413,"url":24,"identifiers":4414},"10.1038\u002Fnprot.2006.378",{"doi":4413},{"id":24,"text":4416,"url":24,"identifiers":4417},"10.1016\u002Fj.jphotobiol.2007.04.002",{"doi":4416},{"id":24,"text":4419,"url":24,"identifiers":4420},"10.1111\u002Fj.1440-1681.2007.04681.x",{"doi":4419},{"id":24,"text":4422,"url":24,"identifiers":4423},"10.1159\u002F000093001",{"doi":4422},{"id":24,"text":4425,"url":24,"identifiers":4426},"10.1038\u002Fnature05292",{"doi":4425},{"id":24,"text":4428,"url":24,"identifiers":4429},"10.1089\u002Fars.2008.2242",{"doi":4428},{"id":24,"text":4431,"url":24,"identifiers":4432},"10.2174\u002F1568007054038238",{"doi":4431},{"id":24,"text":4434,"url":24,"identifiers":4435},"10.1016\u002Fj.redox.2017.06.010",{"doi":4434},{"id":24,"text":4437,"url":24,"identifiers":4438},"10.1073\u002Fpnas.0908397106",{"doi":4437},{"id":24,"text":4440,"url":24,"identifiers":4441},"10.1016\u002Fj.exer.2014.01.021",{"doi":4440},{"id":24,"text":4443,"url":24,"identifiers":4444},"10.1016\u002Fj.brainresbull.2018.09.018",{"doi":4443},{"id":24,"text":4446,"url":24,"identifiers":4447},"10.1111\u002Fcns.12588",{"doi":4446},{"id":24,"text":4449,"url":24,"identifiers":4450},"10.1111\u002Fj.1600-079X.2012.00978.x",{"doi":4449},{"id":24,"text":4452,"url":24,"identifiers":4453},"10.1073\u002Fpnas.222550499",{"doi":4452},{"id":24,"text":4455,"url":24,"identifiers":4456},"10.1007\u002Fs00018-008-8001-x",{"doi":4455},{"id":24,"text":4458,"url":24,"identifiers":4459},"10.1111\u002Fj.1600-079X.2007.00432.x",{"doi":4458},{"id":24,"text":4461,"url":24,"identifiers":4462},"10.1016\u002Fj.freeradbiomed.2014.04.031",{"doi":4461},{"id":24,"text":4464,"url":24,"identifiers":4465},"10.1016\u002Fj.ejphar.2007.06.011",{"doi":4464},{"id":24,"text":4467,"url":24,"identifiers":4468},"10.1089\u002Fars.2005.7.719",{"doi":4467},{"id":24,"text":4470,"url":24,"identifiers":4471},"10.1016\u002Fj.ejogrb.2007.02.014",{"doi":4470},{"id":24,"text":4473,"url":24,"identifiers":4474},"10.1073\u002Fpnas.0711030105",{"doi":4473},{"id":24,"text":4476,"url":24,"identifiers":4477},"10.1186\u002Fs12929-015-0156-9",{"doi":4476},{"id":24,"text":4479,"url":24,"identifiers":4480},"10.1523\u002FJNEUROSCI.3362-09.2009",{"doi":4479},{"id":24,"text":4482,"url":24,"identifiers":4483},"10.1016\u002Fj.aanat.2016.04.029",{"doi":4482},{"id":24,"text":4485,"url":24,"identifiers":4486},"10.1016\u002Fj.jsbmb.2014.02.011",{"doi":4485},{"id":24,"text":4488,"url":24,"identifiers":4489},"10.1016\u002Fj.neuropharm.2013.07.023",{"doi":4488},{"id":24,"text":4491,"url":24,"identifiers":4492},"10.1159\u002F000454681",{"doi":4491},{"id":24,"text":4494,"url":24,"identifiers":4495},"10.1111\u002Fj.1460-9568.2007.05370.x",{"doi":4494},{"id":24,"text":4497,"url":24,"identifiers":4498},"10.1016\u002Fj.stem.2010.03.017",{"doi":4497},{"id":24,"text":4500,"url":24,"identifiers":4501},"10.1016\u002Fj.jchemneu.2016.09.003",{"doi":4500},{"id":24,"text":4503,"url":24,"identifiers":4504},"10.1186\u002Fs13195-016-0206-x",{"doi":4503},{"id":24,"text":4506,"url":24,"identifiers":4507},"10.1523\u002FJNEUROSCI.1567-10.2010",{"doi":4506},{"id":24,"text":4509,"url":24,"identifiers":4510},"10.1016\u002Fj.stem.2007.09.002",{"doi":4509},{"id":24,"text":4512,"url":24,"identifiers":4513},"10.3892\u002For.2015.4145",{"doi":4512},{"id":24,"text":4515,"url":24,"identifiers":4516},"10.3892\u002Fol.2013.1413",{"doi":4515},{"id":24,"text":4518,"url":24,"identifiers":4519},"10.1007\u002Fs00018-004-4144-6",{"doi":4518},{"id":24,"text":4521,"url":24,"identifiers":4522},"10.1002\u002Fstem.541",{"doi":4521},{"id":24,"text":4524,"url":24,"identifiers":4525},"10.1016\u002Fj.bbrc.2016.04.108",{"doi":4524},{"id":24,"text":4527,"url":24,"identifiers":4528},"10.1128\u002FMCB.24.20.8834-8846.2004",{"doi":4527},{"id":4530,"createTime":4531,"updateTime":4531,"relativeEntities":4532,"slug":4533,"properties":4534,"entityType":120,"verifyStatus":121,"verifyTime":4531,"verifyNote":122,"syncStatus":23,"languages":4550,"translateLanguages":24,"viewCount":25,"primaryUrl":4551,"fullTextUrl":24,"authors":4552,"publicationType":220,"publisherRelationship":4733,"citationCount":4756,"citationInfo":4757,"publishDate":4759,"publishYear":4760,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":4761,"isForceReanalyzing":395},"6c8c60b4-004a-4390-9c75-e16b77a5e665","2024-09-30T22:11:33.630+00:00",[],"Curcumin-Reverses-the-Diazepam-Induced-Cognitive-Impairment-by-Modulation-of-Oxidative-Stress-and-ERK-1-2-NF-i-%CE%BA-i-B-Pathway-in-Brain",{"mag":4535,"keywords":4537,"pmc":4538,"openalex":4540,"abstract":4542,"title":4544,"pm":4546,"doi":4548},{"VOID":4536},"2760235365",{},{"VOID":4539},"5643119",{"VOID":4541},"W2760235365",{"EN":4543},"\u003Cjats:p>Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels. The ERK\u002FNF‐\u003Cjats:italic>κ\u003C\u002Fjats:italic>B signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam‐treated rats, were also analyzed. The animals were divided into 4 groups: control, carboxymethylcellulose (CMC) + CUR, CMC + DZP, and CUR + CMC + DZP. CUR (150 mg\u002Fkg b.w.) was orally administered for 28 days. DZP (2 mg\u002Fkg b.w.) was intraperitoneally administered 20 minutes before the behavioral tests (open field test, Y‐maze, and elevated plus maze). CUR improved the spontaneous alternation behavior, decreased the oxidative stress levels, both in the blood and in the hippocampus, and downregulated the extracellular signal‐regulated kinase (ERK 1\u002F2)\u002Fnuclear transcription factor‐ (NF‐) \u003Cjats:italic>κ\u003C\u002Fjats:italic>B\u002FpNF‐\u003Cjats:italic>κ\u003C\u002Fjats:italic>B pathway in the hippocampus and the iNOS expression in the hippocampus and frontal lobe of the DZP‐treated rats. Histopathologically, no microscopic changes were found. The immunohistochemical signal of iNOS decreased in the DZP and CUR‐treated group. Thus, our findings suggest that curcumin administration may improve the cognitive performance and may also have an antioxidant effect.\u003C\u002Fjats:p>",{"EN":4545},"Curcumin Reverses the Diazepam‐Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1\u002F2\u002FNF‐\u003Ci>κ\u003C\u002Fi>B Pathway in Brain",{"VOID":4547},"29098059",{"VOID":4549},"10.1155\u002F2017\u002F3037876",[124],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1155\u002F2017\u002F3037876",[4553,4575,4592,4609,4626,4643,4660,4677,4718],{"id":4554,"sortIndex":248,"researcher":24,"roles":4555,"affiliations":4556,"properties":4568},"e30cc59d-dadb-4e52-ba1a-354c52bf8144",[],[4557],{"id":4558,"sortIndex":25,"affiliation":4559,"properties":24},"3dfaf40e-df6c-462f-84e1-993aa9ef975e",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4563,"slug":4564,"properties":4565,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"e7401f1b-52f5-47b6-9322-c67cbec03809","2024-01-11T03:57:22.155+00:00","2024-09-30T22:11:33.657+00:00",[],"Department-of-Physiology-Iuliu-Hatieganu-University-of-Medicine-and-Pharmacy-1-Clinicilor-Street-400006-Cluj-Napoca-Romania",{"title":4566},{"VI":4567},"Department of Physiology,“Iuliu Hatieganu” University of Medicine and Pharmacy, 1 Clinicilor Street, 400006 Cluj-Napoca, Romania",{"openalex":4569,"orcid":4571,"title":4573},{"VOID":4570},"A5023852822",{"VOID":4572},"https:\u002F\u002Forcid.org\u002F0000-0002-7447-4925",{"EN":4574},"Gabriela Adriana Filip",{"id":4576,"sortIndex":467,"researcher":24,"roles":4577,"affiliations":4578,"properties":4585},"17db8134-cd16-42ea-9595-5b5a85afd2bb",[],[4579],{"id":4580,"sortIndex":25,"affiliation":4581,"properties":24},"33e9eed1-dcb9-4410-90f6-af672afbf17c",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4582,"slug":4564,"properties":4583,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4584},{"VI":4567},{"openalex":4586,"orcid":4588,"title":4590},{"VOID":4587},"A5001061554",{"VOID":4589},"https:\u002F\u002Forcid.org\u002F0000-0002-8707-957X",{"EN":4591},"Nicoleta Decea",{"id":4593,"sortIndex":468,"researcher":24,"roles":4594,"affiliations":4595,"properties":4602},"1b049117-49bf-4f3a-9281-90b8f62f1a98",[],[4596],{"id":4597,"sortIndex":25,"affiliation":4598,"properties":24},"76c596fa-4b5a-479a-85e2-4df91dab3f45",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4599,"slug":4564,"properties":4600,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4601},{"VI":4567},{"openalex":4603,"orcid":4605,"title":4607},{"VOID":4604},"A5021671663",{"VOID":4606},"https:\u002F\u002Forcid.org\u002F0000-0002-0046-0803",{"EN":4608},"Simona Clichici",{"id":4610,"sortIndex":129,"researcher":24,"roles":4611,"affiliations":4612,"properties":4619},"415d1d05-8da0-49a4-9412-f66eaaa6b335",[],[4613],{"id":4614,"sortIndex":25,"affiliation":4615,"properties":24},"77d6053d-2149-4b54-a777-5ccdd4e8999b",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4616,"slug":4564,"properties":4617,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4618},{"VI":4567},{"openalex":4620,"orcid":4622,"title":4624},{"VOID":4621},"A5009971287",{"VOID":4623},"https:\u002F\u002Forcid.org\u002F0000-0003-4046-7310",{"EN":4625},"Ioana Bâldea",{"id":4627,"sortIndex":469,"researcher":24,"roles":4628,"affiliations":4629,"properties":4636},"c303a0cb-315d-4298-87e3-4db195c2980e",[],[4630],{"id":4631,"sortIndex":25,"affiliation":4632,"properties":24},"9eb76059-5f51-4b60-bfb2-9ae2abc7921d",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4633,"slug":4564,"properties":4634,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4635},{"VI":4567},{"openalex":4637,"orcid":4639,"title":4641},{"VOID":4638},"A5067348729",{"VOID":4640},"https:\u002F\u002Forcid.org\u002F0000-0002-8459-8657",{"EN":4642},"Remus Moldovan",{"id":4644,"sortIndex":204,"researcher":24,"roles":4645,"affiliations":4646,"properties":4653},"038034d7-50a1-4867-ae61-96b3f94714c9",[],[4647],{"id":4648,"sortIndex":25,"affiliation":4649,"properties":24},"e04bc7fc-eb3f-47a5-ae2c-d37113f25ab6",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4650,"slug":4564,"properties":4651,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4652},{"VI":4567},{"openalex":4654,"orcid":4656,"title":4658},{"VOID":4655},"A5060818529",{"VOID":4657},"https:\u002F\u002Forcid.org\u002F0000-0002-3034-3659",{"EN":4659},"Diana Olteanu",{"id":4661,"sortIndex":169,"researcher":24,"roles":4662,"affiliations":4663,"properties":4670},"a79175ec-4aa9-4fe7-898a-e6e8e9aa502a",[],[4664],{"id":4665,"sortIndex":25,"affiliation":4666,"properties":24},"89a598cb-35b1-499b-a9cf-5d0e5361d595",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4667,"slug":4564,"properties":4668,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4669},{"VI":4567},{"openalex":4671,"orcid":4673,"title":4675},{"VOID":4672},"A5058436792",{"VOID":4674},"https:\u002F\u002Forcid.org\u002F0000-0001-8425-8399",{"EN":4676},"Vlad Făgărăşan",{"id":4678,"sortIndex":151,"researcher":24,"roles":4679,"affiliations":4680,"properties":4711},"842028a4-8ddb-4d80-aef5-32a9902baa24",[],[4681,4691,4701],{"id":4682,"sortIndex":25,"affiliation":4683,"properties":24},"9fea28eb-99e4-47ca-af2f-16b7239fa9cd",{"id":4684,"createTime":4685,"updateTime":4685,"relativeEntities":4686,"slug":4687,"properties":4688,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"943fdde1-8caf-4ecb-80c2-b9d486748226","2024-09-30T22:11:33.688+00:00",[],"Department-of-Biochemistry-and-Experimental-Biology-Institute-of-Biological-Research-Republicii-Street-No-48-branch-of-NIRDBS-Bucharest-Cluj-Napoca-Romania",{"title":4689},{"EN":4690},"Department of Biochemistry and Experimental Biology, Institute of Biological Research, Republicii Street No. 48, branch of NIRDBS Bucharest, Cluj-Napoca, Romania",{"id":4692,"sortIndex":151,"affiliation":4693,"properties":24},"c3ccd71d-74e8-42f1-901c-765ca736f1b2",{"id":4694,"createTime":4695,"updateTime":4695,"relativeEntities":4696,"slug":4697,"properties":4698,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"488f1404-975b-4425-bf5f-be260c7aac13","2024-09-30T22:11:33.703+00:00",[],"Department-of-Molecular-and-Biomolecular-Physics-NIRD-for-Isotopic-and-Molecular-Technologies-Donat-Street-No-101-Cluj-Napoca-Romania",{"title":4699},{"EN":4700},"Department of Molecular and Biomolecular Physics, NIRD for Isotopic and Molecular Technologies, Donat Street No. 101, Cluj-Napoca, Romania",{"id":4702,"sortIndex":169,"affiliation":4703,"properties":24},"9e15a484-bd6b-4ca1-b39b-66e25c4d6984",{"id":4704,"createTime":4705,"updateTime":4705,"relativeEntities":4706,"slug":4707,"properties":4708,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"8fa26716-b427-44a5-a51c-b91f8d8e584c","2024-09-30T22:11:33.696+00:00",[],"Department-of-Molecular-Biology-and-Biotechnology-Faculty-of-Biology-and-Geology-Babes-Bolyai-University-Clinicilor-Street-No-5-7-Cluj-Napoca-Romania",{"title":4709},{"EN":4710},"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Clinicilor Street No. 5-7, Cluj-Napoca, Romania",{"openalex":4712,"orcid":4714,"title":4716},{"VOID":4713},"A5068524766",{"VOID":4715},"https:\u002F\u002Forcid.org\u002F0000-0002-1141-2559",{"EN":4717},"Vlad Alexandru Toma",{"id":4719,"sortIndex":25,"researcher":24,"roles":4720,"affiliations":4721,"properties":4728},"3cc36988-1420-4f5d-94c3-4a7e9c0c1463",[],[4722],{"id":4723,"sortIndex":25,"affiliation":4724,"properties":24},"2da23640-b353-43fe-9b67-cbac3f991fe0",{"id":4560,"createTime":4561,"updateTime":4562,"relativeEntities":4725,"slug":4564,"properties":4726,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4727},{"VI":4567},{"openalex":4729,"title":4731},{"VOID":4730},"A5027281522",{"EN":4732},"Alexandra Sevastre-Berghian",{"url":24,"publisher":4734,"properties":4752},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":4735,"slug":10,"properties":4736,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":4742,"manageAffiliations":4743,"indexDatabases":4744,"url":94,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":4737,"issn":4738,"introduce":4739,"eissn":4740,"title":4741},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[4745],{"id":73,"indexDatabase":4746,"url":86,"indexYears":87,"academicFieldIds":4751,"indexDatabaseRanking":93},{"id":75,"createTime":76,"updateTime":77,"relativeEntities":4747,"label":4748,"description":4749,"key":83,"publicationTags":4750,"standard":24},[],{"EN":80,"VI":80},{"EN":80,"VI":82},[85],[89,90,91,92],{"volume":4753,"issue":4755},{"VOID":4754},"2017",{"VOID":836},35,{"total":4756,"publishYear":24,"statisticByYear":4758},{"2018":151,"2019":129,"2020":248,"2021":249,"2022":468,"2023":204,"2024":151},"2017-01-01",2017,[4762,4765,4768,4771,4774,4777,4780,4783,4786,4789,4792,4795,4798,4801,4804,4807,4810,4813,4816,4819,4822,4825,4828,4831,4834,4837,4840,4843,4846,4849,4852,4855,4858,4861,4864,4867,4870,4873,4876,4879,4882,4885,4888,4891,4894,4897,4900,4903,4906,4909,4912,4915,4918,4921,4924,4927,4930,4933,4936,4939],{"id":24,"text":4763,"url":24,"identifiers":4764},"Bigoniya P., 2015, Nootropic efficacy of Euphorbia thymifolia Linn phytosterol on mice, International Journal of Phytotherapy, 5, 22",{},{"id":24,"text":4766,"url":24,"identifiers":4767},"Dimitrova D., 2015, Comparison of the effects of different doses diazepam on learning and memory processes in rats using active and passive avoidance tests, Indian Journal of Pharmaceutical Science & Research, 5, 112",{},{"id":24,"text":4769,"url":24,"identifiers":4770},"10.4103\u002F0976-9668.117025",{"doi":4769},{"id":24,"text":4772,"url":24,"identifiers":4773},"Kumar M., 2015, Amelioration of diazepam induced memory impairment by fruit of Cucumis sativus L in aged mice by using animal models of Alzheimer’s disease, International Journal of Pharmacy and Pharmaceutical Research, 6, 1015",{},{"id":24,"text":4775,"url":24,"identifiers":4776},"10.1016\u002Fj.jns.2007.01.039",{"doi":4775},{"id":24,"text":4778,"url":24,"identifiers":4779},"Fu W., 2015, Plant-derived neuroprotective agents in Parkinson’s disease, American Journal of Translational Research, 7, 1189",{},{"id":24,"text":4781,"url":24,"identifiers":4782},"10.1016\u002Fj.jneuroim.2006.11.013",{"doi":4781},{"id":24,"text":4784,"url":24,"identifiers":4785},"10.1038\u002Fnrn1434",{"doi":4784},{"id":24,"text":4787,"url":24,"identifiers":4788},"10.1002\u002Fana.20624",{"doi":4787},{"id":24,"text":4790,"url":24,"identifiers":4791},"10.1007\u002Fs00401-004-0952-x",{"doi":4790},{"id":24,"text":4793,"url":24,"identifiers":4794},"10.1186\u002F1750-1326-4-8",{"doi":4793},{"id":24,"text":4796,"url":24,"identifiers":4797},"10.1371\u002Fjournal.pone.0134156",{"doi":4796},{"id":24,"text":4799,"url":24,"identifiers":4800},"10.1155\u002F2007\u002F10767",{"doi":4799},{"id":24,"text":4802,"url":24,"identifiers":4803},"10.1155\u002F2016\u002F5017460",{"doi":4802},{"id":24,"text":4805,"url":24,"identifiers":4806},"10.1016\u002Fj.brainresbull.2012.02.008",{"doi":4805},{"id":24,"text":4808,"url":24,"identifiers":4809},"10.1590\u002Fs1516-93322008000400019",{"doi":4808},{"id":24,"text":4811,"url":24,"identifiers":4812},"10.1248\u002Fjhs.53.43",{"doi":4811},{"id":24,"text":4814,"url":24,"identifiers":4815},"Griffin C. E., 2013, Benzodiazepine pharmacology and central nervous system-mediated effects, The Ochsner Journal, 13, 214",{},{"id":24,"text":4817,"url":24,"identifiers":4818},"10.7598\u002Fcst2014.616",{"doi":4817},{"id":24,"text":4820,"url":24,"identifiers":4821},"10.1111\u002Fj.1365-2125.2012.04418.x",{"doi":4820},{"id":24,"text":4823,"url":24,"identifiers":4824},"Uzun S., 2010, Side effects of treatment with benzodiazepines, Psychiatria Danubina, 22, 90",{},{"id":24,"text":4826,"url":24,"identifiers":4827},"10.1100\u002Ftsw.2006.243",{"doi":4826},{"id":24,"text":4829,"url":24,"identifiers":4830},"10.2174\u002F1381612023396654",{"doi":4829},{"id":24,"text":4832,"url":24,"identifiers":4833},"10.1523\u002FJNEUROSCI.1067-04.2004",{"doi":4832},{"id":24,"text":4835,"url":24,"identifiers":4836},"10.1254\u002Fjphs.fp0061565",{"doi":4835},{"id":24,"text":4838,"url":24,"identifiers":4839},"10.1155\u002F2014\u002F974308",{"doi":4838},{"id":24,"text":4841,"url":24,"identifiers":4842},"10.1016\u002Fj.jep.2015.03.053",{"doi":4841},{"id":24,"text":4844,"url":24,"identifiers":4845},"10.1016\u002Fj.bbr.2006.08.021",{"doi":4844},{"id":24,"text":4847,"url":24,"identifiers":4848},"Uma S., 2010, Effect of Saraswatarishta on learning and memory, International Journal of Phytopharmacology, 1, 15",{},{"id":24,"text":4850,"url":24,"identifiers":4851},"10.1038\u002Fnprot.2007.44",{"doi":4850},{"id":24,"text":4853,"url":24,"identifiers":4854},"10.1093\u002Fclinchem\u002F37.7.1273",{"doi":4853},{"id":24,"text":4856,"url":24,"identifiers":4857},"10.1016\u002Fs0076-6879(94)33044-1",{"doi":4856},{"id":24,"text":4859,"url":24,"identifiers":4860},"10.1371\u002Fjournal.pone.0149309",{"doi":4859},{"id":24,"text":4862,"url":24,"identifiers":4863},"10.1002\u002Fbrb3.197",{"doi":4862},{"id":24,"text":4865,"url":24,"identifiers":4866},"10.1016\u002Fj.tips.2008.07.005",{"doi":4865},{"id":24,"text":4868,"url":24,"identifiers":4869},"10.35652\u002FIGJPS.2012.15",{"doi":4868},{"id":24,"text":4871,"url":24,"identifiers":4872},"10.1016\u002Fj.bcp.2014.01.011",{"doi":4871},{"id":24,"text":4874,"url":24,"identifiers":4875},"10.1002\u002Fjbt.21815",{"doi":4874},{"id":24,"text":4877,"url":24,"identifiers":4878},"10.1023\u002FA:1006834706117",{"doi":4877},{"id":24,"text":4880,"url":24,"identifiers":4881},"10.1111\u002Fj.1742-7843.2011.00738.x",{"doi":4880},{"id":24,"text":4883,"url":24,"identifiers":4884},"10.1089\u002Fars.2010.3474",{"doi":4883},{"id":24,"text":4886,"url":24,"identifiers":4887},"10.2174\u002F1570159x11666131120223530",{"doi":4886},{"id":24,"text":4889,"url":24,"identifiers":4890},"10.1007\u002Fbf00169053",{"doi":4889},{"id":24,"text":4892,"url":24,"identifiers":4893},"10.1186\u002Fs40816-016-0031-6",{"doi":4892},{"id":24,"text":4895,"url":24,"identifiers":4896},"10.1016\u002F0091-3057(95)02028-4",{"doi":4895},{"id":24,"text":4898,"url":24,"identifiers":4899},"10.1002\u002Fhup.747",{"doi":4898},{"id":24,"text":4901,"url":24,"identifiers":4902},"10.4236\u002Fjbbs.2013.31008",{"doi":4901},{"id":24,"text":4904,"url":24,"identifiers":4905},"10.3389\u002Ffphar.2016.00261",{"doi":4904},{"id":24,"text":4907,"url":24,"identifiers":4908},"10.1016\u002Fj.sjbs.2013.01.002",{"doi":4907},{"id":24,"text":4910,"url":24,"identifiers":4911},"10.2147\u002FIJN.S94622",{"doi":4910},{"id":24,"text":4913,"url":24,"identifiers":4914},"10.1093\u002Farclin\u002F16.6.571",{"doi":4913},{"id":24,"text":4916,"url":24,"identifiers":4917},"10.1111\u002Fjcmm.12748",{"doi":4916},{"id":24,"text":4919,"url":24,"identifiers":4920},"10.1016\u002Fj.intimp.2011.12.009",{"doi":4919},{"id":24,"text":4922,"url":24,"identifiers":4923},"10.18632\u002Foncotarget.6553",{"doi":4922},{"id":24,"text":4925,"url":24,"identifiers":4926},"10.4137\u002FCGM.S11113",{"doi":4925},{"id":24,"text":4928,"url":24,"identifiers":4929},"10.1016\u002F0014-5793(86)81188-7",{"doi":4928},{"id":24,"text":4931,"url":24,"identifiers":4932},"10.1038\u002Fnn1110",{"doi":4931},{"id":24,"text":4934,"url":24,"identifiers":4935},"10.1523\u002FJNEUROSCI.5646-03.2004",{"doi":4934},{"id":24,"text":4937,"url":24,"identifiers":4938},"10.1016\u002FS0074-7742(09)85024-1",{"doi":4937},{"id":24,"text":4940,"url":24,"identifiers":4941},"10.1523\u002FJNEUROSCI.5880-09.2010",{"doi":4940}]