[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_cd70ea97-b579-4098-8b80-a6547b410f22":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:cd70ea97-b579-4098-8b80-a6547b410f22,\"}":164},{"code":4,"data":5,"meta":18},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":20,"manageAffiliations":69,"indexDatabases":92,"url":18,"thumbnailPath":18,"statistic":136,"gsStatistic":18,"type":18,"analyzePriority":18},"cd70ea97-b579-4098-8b80-a6547b410f22","2024-04-19T10:32:00.084+00:00","2024-10-08T01:02:34.808+00:00",[],"Oxford-University-Press-OUP-",{"eissn":12,"title":14},{"VOID":13},"2321-3876",{"EN":15},"Oxford University Press (OUP)","PUBLISHER","PENDING",null,0,[21,29,37,45,53,61],{"id":22,"createTime":23,"updateTime":24,"relativeEntities":25,"label":26,"description":28,"parentId":18,"standard":18,"scholarHubFieldId":18},"6dc081f7-79a9-45f6-8ed3-54ef5518db41","2023-05-29T10:24:14.547+00:00","2023-11-21T07:19:21.114+00:00",[],{"EN":27},"Immunology and Allergy",{},{"id":30,"createTime":31,"updateTime":32,"relativeEntities":33,"label":34,"description":36,"parentId":18,"standard":18,"scholarHubFieldId":18},"d14f40c0-965c-4844-8f95-356ee60db573","2023-05-29T10:24:32.595+00:00","2023-11-21T04:26:11.392+00:00",[],{"EN":35},"Critical Care and Intensive Care Medicine",{},{"id":38,"createTime":39,"updateTime":40,"relativeEntities":41,"label":42,"description":44,"parentId":18,"standard":18,"scholarHubFieldId":18},"8a22f541-bc66-4391-94d0-fcc48082cbe0","2023-05-29T10:24:51.770+00:00","2023-11-21T07:20:23.744+00:00",[],{"EN":43},"Emergency Medicine",{},{"id":46,"createTime":47,"updateTime":48,"relativeEntities":49,"label":50,"description":52,"parentId":18,"standard":18,"scholarHubFieldId":18},"ffc13648-0fbc-4664-b83e-4b3b3abeb01f","2023-05-29T10:24:01.367+00:00","2023-11-21T07:56:41.429+00:00",[],{"EN":51},"Biomedical Engineering",{},{"id":54,"createTime":55,"updateTime":56,"relativeEntities":57,"label":58,"description":60,"parentId":18,"standard":18,"scholarHubFieldId":18},"f3c7480d-9f85-464a-ad0d-807993a45c26","2023-05-29T10:24:08.731+00:00","2023-11-21T08:02:49.957+00:00",[],{"EN":59},"Surgery",{},{"id":62,"createTime":63,"updateTime":64,"relativeEntities":65,"label":66,"description":68,"parentId":18,"standard":18,"scholarHubFieldId":18},"28cfae05-23d6-408f-bb12-6e6dd34cf326","2023-05-29T10:24:23.114+00:00","2023-11-21T06:38:20.156+00:00",[],{"EN":67},"Dermatology",{},[70,82],{"id":71,"createTime":72,"updateTime":73,"relativeEntities":74,"slug":75,"properties":76,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":80,"url":18,"parentIds":81,"statistic":18},"2bc101c3-b2fa-462b-9498-b1c3a2f9ba51","2023-05-29T12:08:02.996+00:00","2024-02-18T12:06:12.696+00:00",[],"OXFORD-UNIV-PRESS",{"title":77},{"EN":78},"OXFORD UNIV PRESS","AFFILIATION",4,[],{"id":83,"createTime":84,"updateTime":85,"relativeEntities":86,"slug":87,"properties":88,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":80,"url":18,"parentIds":91,"statistic":18},"3b2b3c1e-d793-4160-89dd-eb4e42b70e4a","2023-05-29T10:24:01.308+00:00","2025-11-21T10:07:42.786+00:00",[],"Oxford-University-Press",{"title":89},{"EN":90},"Oxford University Press",[],[93,116],{"id":94,"indexDatabase":95,"url":107,"indexYears":108,"academicFieldIds":109,"indexDatabaseRanking":18},"7a7f9ee9-e467-486f-afdc-7d1b62e51219",{"id":96,"createTime":97,"updateTime":98,"relativeEntities":99,"label":100,"description":102,"key":104,"publicationTags":105,"standard":18},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":101,"VI":101},"Scopus - Elsevier",{"EN":101,"VI":103},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[106],"SCOPUS","https:\u002F\u002Fwww.scimagojr.com\u002Fjournalsearch.php?q=21101039773&tip=sid&clean=0","2021-2022",[110,111,112,113,114,115],"920e4aa8-a8d2-44a1-a417-38b5d792a432","da3f207d-dfb1-4954-9e7a-e9bc72dda058","ee3d8fb9-b2a1-4d93-88cf-96b23637734c","766ed3e7-3541-4391-a941-981c35e5058b","d729cb0b-d468-4829-9bfc-9e3b992eeefe","e872d6d8-194c-4b83-9ea3-8b78dd28210d",{"id":117,"indexDatabase":118,"url":18,"indexYears":18,"academicFieldIds":132,"indexDatabaseRanking":18},"8a626631-96f3-49a3-a337-ce7740c84335",{"id":119,"createTime":120,"updateTime":121,"relativeEntities":122,"label":123,"description":125,"key":128,"publicationTags":129,"standard":18},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":124,"VI":124},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":126,"EN":127},"Cơ sở dữ liệu SCIE","SCIE database","scie",[130,131],"SCIE","ISI",[133,134,135],"4f95fc5c-bf89-4e25-8491-ac1ea476763b","7df44285-f252-4d1a-bce1-a0535f1f6ec0","1feaf4f7-c4fe-4c9f-aa70-8cd93767f200",{"impactFactor":19,"impactFactorByYear":137,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":146,"totalCitation":151,"totalCitationByYear":152,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":158,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},0.54,1.1,0.26,0.59,0.65,10,3,134,{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},18,21,26,20,471,{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},314,9,99,46,3.51,{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},0.17,14.95,0.43,3.81,2.3,{"meta":165,"data":167},{"total":166},"134",[168,310,426,532,626,753,1402,1556,1713,1800],{"id":169,"createTime":170,"updateTime":171,"relativeEntities":172,"slug":173,"properties":174,"entityType":183,"verifyStatus":184,"verifyTime":171,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":186,"fullTextUrl":18,"authors":187,"publicationType":273,"publisherRelationship":274,"citationCount":18,"citationInfo":18,"publishDate":307,"publishYear":308,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"5ba03f83-04a0-47c9-950a-c548b0da4372","2024-01-29T08:14:07.267+00:00","2025-01-03T23:52:01.519+00:00",[],"Perspectives-of-caregivers-towards-physiotherapy-treatment-for-children-with-burns-in-Harare-Zimbabwe-A-cross-sectional-study",{"references":175,"abstract":177,"title":179,"doi":181},{"VOID":176},"World Health Organisation. Burns. Available on http:\u002F\u002Fwww.who.int\u002Fviolence_injury_prevention\u002Fother_injury\u002Fburns\u002Fen\u002F. Last Accessed 07 July 2016.\nForjuoh S, Gielen A. Chapter 4. Burns. In: Peden M, Oyegbite K, Ozanne-Smith J, Hyder AA, Branche C, Fazlur Rahman AKM, Rivara F, Bartolomeos K, editors. World report on child injury and prevention. Geneva: World Health Organization; 2008. p. 79–98.\nStachowski M, Cebulski PK. Physical therapists in burn care: role and staffing patterns. Phys Ther. 1983;63:1091–5.\nBurd A, Yuen C. A global study of hospitalized paediatric burn patients. Burns. 2005;31(4):432–8.\nSamuel JC, Campbell ELP, Mjuweni S, Muyco AP, Cairns BA, Charles AG. The epidemiology, management, outcomes and areas for improvement of burn care in central Malawi: an observational study. Int Med Res. 2011;39(3):873–9.\nAlbertyn R, Numanoglu A, Rode N. Pediatric burn care in sub-Saharan Africa. Afr J Trauma. 2014;3(2):61–7.\nZimbabwe National Statistics Agency (ZIMSTAT). Compendium of statistics. Available on http:\u002F\u002Fwww.zimstat.co.zw\u002Fsites\u002Fdefault\u002Ffiles\u002Fimg\u002Fpublications\u002FOther\u002FCompendium2012.pdf . Last Accessed 07 July 2016.\nMzezewa S, Jonsson K, Aberg M, Salemark L. A prospective study on the epidemiology of burns in patients admitted to the Harare burns units. Burns. 1999;25(6):499–504.\nSimons MA, Kimble RM. 2010. Pediatric burns. In: JH Stone, M Blouin, editors. International Encyclopedia of Rehabilitation. Available online: http:\u002F\u002Fcirrie.buffalo.edu\u002Fencyclopedia\u002Fen\u002Farticle\u002F119\u002F . Last Accessed 07 July 2016.\nAtiyeh B, Janom HH. Physical rehabilitation of paediatric burns. Ann Burns Fire Disasters. 2014;27(1):37–43.\nMock C, Peck M, Peden M, Krug E, eds. A WHO plan for burn prevention and care. Geneva, World Health Organization, 2008. Available on http:\u002F\u002Fapps.who.int\u002Firis\u002Fbitstream\u002F10665\u002F97852\u002F1\u002F9789241596299_eng.pdf. Last Accessed 07 July 2016.\nPeck M, Molnar J, Swart D. A global plan for burn prevention and care. Bull World Health Organ. 2009;87(10):802–3.\nBlakeney P, Meyer W, Robert R, Desai M, Wolf S, Herndon D. Long-term psychosocial adaptation of children who survive burns involving 80 % or greater total body surface area. J Trauma. 1998;44(4):625–32.\nDe Sousa A. Psychological aspects of paediatric burns: a clinical review. Ann Burns Fire Disasters. 2010;23(3):155–9.\nEsselman P. Burns rehabilitation: an overview. Arch Phys Med Rehabil. 2007;88(2):3–6.\nSuman O, Spies R, Celis M, Mlcak R, Herndon D. Effects of a 12-wk resistance exercise programme on skeletal muscle strength in children with burn injuries. J Appl Physiol. 2001;91(3):1168–75.\nProcter F. Rehabilitation of the burn patient. Ind J Plast Surg. 2010;43(3):101–13.\nVasli P, Salsali M. Parents’ participation in the taking care of hospitalized children: concept analysis with hybrid model. Iran J Nurs Midwifery Res. 2014;19(2):139–44.\nHellem E, Bruusgaard KA. Exercise maintenance COPD patients’ perception and perspectives on elements of success in sustaining long-term exercise. Physiother Theory Practice. 2012;28(3):206–20.\nSaloojee GM, Rosenbaum PL, Stewart AV. Using caregivers’ perceptions of rehabilitation services for children with Cerebral Palsy at public sector hospitals to identify the components of an appropriate service. S Afr J Physiother. 2011;67(3):35–40.\nDavis LL. Instrument review: getting the most from a panel of experts. Appl Nurs Res. 1992;5:194–7.\nJeanne R. Perceptions among caregivers and physiotherapist on the importance of chest physiotherapy in asthmatic children attending hospitals in Kigali, Rwanda. MSc Thesis. The University of the Witwatersrand. 2004; 1-94. Available on http:\u002F\u002Fetd.uwc.ac.za\u002Fxmlui\u002Fbitstream\u002Fhandle\u002F11394\u002F1576\u002FRemera_MSC_2004.pdf?sequence=1. Last Accessed 07 July 2016.\nPai MS, Kumar V, Janthosh PP, Sundeep PT. Socio-demographic characteristcis of mothers of hospitalised children in surgical wards. Int J Curr Res. 2015;7(9):20676–79.\nKadir AR. Paediatric burns in Sulaimani. Iraq Ann Burns Fire Disasters. 2007;20(3):121–5.\nOutwater AH, Ismail H, Mgalilwa L, Temu MJ, Mbembati NA. Burns in Tanzania: morbidity and mortality, causes and risk factors: a review. Int J Burn Trauma. 2013;3(1):18–29.\nCen Y, Chai J, Chen J, Chen H, Chen J, Guo G, et al. Guidelines for burn rehabilitation in China. Burns Trauma. 2015;3:20.\nBrown NJ, Kimble RM, Gramotnev G, Rodger S, Cuttle L. Predictors of re-epithelialization in pediatric burn. Burns. 2014;40(4):751–8.",{"EN":178},"Physiotherapy is an integral part of treatment for paediatric burns. In Zimbabwe, children are admitted in paediatric burn unit with their caregivers, who play important roles such as providing explanation and obtaining cooperation of the child during physiotherapy, which is often uncomfortable or painful to the patient. The aim of this study was to determine the perspectives of caregivers towards physiotherapy interventions administered to hospitalized children at central hospitals in Harare, Zimbabwe. A descriptive cross-sectional study was conducted using self-administered questionnaires. The study was carried out at two large central hospitals (Parirenyatwa Hospital and Harare Central Hospital). The study targeted all the caregivers of children below the age of 12 years with a diagnosis of burns, irrespective of severity or area affected, who were admitted in the two paediatric burn units. Of the 34 caregivers eligible to participate, 31 (91.1 %) questionnaires had complete data and were analysed. The analyses were done using Statistica version 12.0. The median age of the caregivers was 28 years (IQR = 24–33 years). Female caregivers constituted 90.3 % of the sample. The majority of the caregivers (n = 26, 83.9 %) were biological mothers to the hospitalised child. The majority of children (n = 20, 64.5 %) hospitalised were between 0 and 4 years. The commonest cause of burns was scalding (n = 19, 61.2 %). The burns were mainly in the upper extremities (n = 11, 35.5 %). Physiotherapy for the burns was mainly active and passive joint range of motion exercises (n = 30, 96.8 %). The caregivers’ perceptions towards physiotherapy were mainly positive (n = 20, 64.5 %) indicating that physiotherapy plays an important role in burn management. Of the 21 caregivers given a ward exercise programme, 13 (61.9 %) were not compliant. Caregivers’ perspectives towards physiotherapy were largely positive and are similar to those found in other studies. The majority of the caregivers indicated that physiotherapy was important in the overall management of burns leading to proper healing of the wounds without complications.",{"EN":180},"Perspectives of caregivers towards physiotherapy treatment for children with burns in Harare, Zimbabwe: A cross-sectional study",{"VOID":182},"10.1186\u002Fs41038-016-0057-5","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002Fdoi\u002F10.1186\u002Fs41038-016-0057-5\u002F5671089",[188,205,220,236,248,260],{"id":189,"sortIndex":190,"researcher":18,"roles":191,"affiliations":193,"properties":202},"a4e1e744-c233-45d3-8db4-f7a63115ef93",5,[192],"AUTHOR",[194],{"id":18,"sortIndex":19,"affiliation":195,"properties":18},{"id":196,"createTime":197,"updateTime":197,"relativeEntities":198,"slug":18,"properties":199,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"cc8c8201-113f-4efe-a2b5-193fb9d9f66d","2024-01-29T08:14:07.343+00:00",[],{"title":200},{"VI":201},"Department of Rehabilitation, Harare Central Hospital, Harare, Zimbabwe",{"title":203},{"VI":204},"Tapfuma Mudawarima",{"id":206,"sortIndex":19,"researcher":18,"roles":207,"affiliations":208,"properties":217},"d8414b00-c660-4444-8786-da8bf66a2cfc",[192],[209],{"id":18,"sortIndex":19,"affiliation":210,"properties":18},{"id":211,"createTime":212,"updateTime":212,"relativeEntities":213,"slug":18,"properties":214,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8f000e71-e1cc-4a13-8a46-2ed1b956aefc","2024-01-12T11:23:53.846+00:00",[],{"title":215},{"VI":216},"Department of Rehabilitation, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe",{"title":218},{"VI":219},"Matthew Chiwaridzo",{"id":221,"sortIndex":222,"researcher":18,"roles":223,"affiliations":224,"properties":233},"9dd3125e-f9a3-4bd1-9254-2965dbe93d3c",1,[192],[225],{"id":18,"sortIndex":19,"affiliation":226,"properties":18},{"id":227,"createTime":228,"updateTime":228,"relativeEntities":229,"slug":18,"properties":230,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"0db15d8d-ca75-4c1d-876b-dfe765486917","2024-01-29T08:14:07.293+00:00",[],{"title":231},{"VI":232},"Trauma Center Physiotherapy Private Practice, Harare, Zimbabwe",{"title":234},{"VI":235},"Vimbayinashe Juliet Zinyando",{"id":237,"sortIndex":144,"researcher":18,"roles":238,"affiliations":239,"properties":245},"4c5e9bf3-68a7-497c-97c7-1cba822b9a0c",[192],[240],{"id":18,"sortIndex":19,"affiliation":241,"properties":18},{"id":211,"createTime":212,"updateTime":212,"relativeEntities":242,"slug":18,"properties":243,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":244},{"VI":216},{"title":246},{"VI":247},"Farayi Kaseke",{"id":249,"sortIndex":80,"researcher":18,"roles":250,"affiliations":251,"properties":257},"20a82282-b35a-4988-9135-7ebdd9a6a589",[192],[252],{"id":18,"sortIndex":19,"affiliation":253,"properties":18},{"id":211,"createTime":212,"updateTime":212,"relativeEntities":254,"slug":18,"properties":255,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":256},{"VI":216},{"title":258},{"VI":259},"Nyaradzai Munambah",{"id":261,"sortIndex":262,"researcher":18,"roles":263,"affiliations":264,"properties":270},"811b9af1-d822-4c66-80d8-e88a8fdd7e41",2,[192],[265],{"id":18,"sortIndex":19,"affiliation":266,"properties":18},{"id":211,"createTime":212,"updateTime":212,"relativeEntities":267,"slug":18,"properties":268,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":269},{"VI":216},{"title":271},{"VI":272},"Jermaine Matewu Dambi","ARTICLE",{"url":186,"publisher":275,"properties":302},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":276,"slug":10,"properties":277,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":280,"manageAffiliations":281,"indexDatabases":282,"url":18,"thumbnailPath":18,"statistic":297,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":278,"title":279},{"VOID":13},{"EN":15},[],[],[283,290],{"id":94,"indexDatabase":284,"url":107,"indexYears":108,"academicFieldIds":289,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":285,"label":286,"description":287,"key":104,"publicationTags":288,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":291,"url":18,"indexYears":18,"academicFieldIds":296,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":292,"label":293,"description":294,"key":128,"publicationTags":295,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":298,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":299,"totalCitation":151,"totalCitationByYear":300,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":301,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":303,"pages":305},{"VOID":304},"4",{"VOID":306},"1-8","2016-12-02",2016,false,{"id":311,"createTime":312,"updateTime":313,"relativeEntities":314,"slug":315,"properties":316,"entityType":183,"verifyStatus":184,"verifyTime":313,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":325,"fullTextUrl":18,"authors":326,"publicationType":273,"publisherRelationship":391,"citationCount":18,"citationInfo":18,"publishDate":424,"publishYear":425,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"4fe4ef6e-0b51-47e0-a59b-4c54ca37d683","2024-01-10T22:04:48.777+00:00","2025-01-31T23:48:29.049+00:00",[],"Collective-cell-migration-Implications-for-wound-healing-and-cancer-invasion",{"references":317,"abstract":319,"title":321,"doi":323},{"VOID":318},"Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 2009;10:445–57.\nGhysen A, Dambly-Chaudiere C. The lateral line microcosmos. Genes Dev 2007;21:2118–30.\nMontell DJ. Morphogenetic cell movements: Diversity from modular mechanical properties. Science 2008;322:1502–5.\nEwald AJ, Brenot A, Duong M, Chan BS, Werb Z. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev Cell 2008;14:570–81.\nTheveneau E, Marchant L, Kuriyama S, Gull M, Moepps B, Parsons M, et al. Collective chemotaxis requires contact-dependent cell polarity. Dev Cell 2010;19:39–53.\nLi L, Hartley R, Reiss B, Sun Y, Pu J, Wu D, et al. E-cadherin plays an essential role in collective directional migration of large epithelial sheets. Cell Mol Life Sci 2012;69:2779–89.\nRenkawitz J, Sixt M. Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Rep 2010;11:744–50.\nFournier MF, Sauser R, Ambrosi D, Meister JJ, Verkhovsky AB. Force transmission in migrating cells. J Cell Biol 2010;188:287–97.\ndu Roure O, Saez A, Buguin A, Austin RH, Chavrier P, Silberzan P, et al. Force mapping in epithelial cell migration. Proc Natl Acad Sci U S A 2005;102:2390–5.\nRorth P. Collective guidance of collective cell migration. Trends Cell Biol 2007;17:575–9.\nPoujade M, Grasland-Mongrain E, Hertzog A, Jouanneau J, Chavrier P, Ladoux B, et al. Collective migration of an epithelial monolayer in response to a model wound. Proc Natl Acad Sci U S A 2007;104:15988–93.\nFong E, Tzlil S, Tirrell DA. Boundary crossing in epithelial wound healing. Proc Natl Acad Sci U S A 2010;107:19302–7.\nVitorino P, Hammer M, Kim J, Meyer T. A steering model of endothelial sheet migration recapitulates monolayer integrity and directed collective migration. Mol Cell Biol 2011;31:342–50.\nBuck RC. Cell migration in repair of mouse corneal epithelium. Invest Ophthalmol Vis Sci 1979;18:767–84.\nBrewitt H. Sliding of epithelium in experimental corneal wounds. A scanning electron microscopic study. Acta Ophthalmol (Copenh) 1979;57:945–58.\nKuwabara T, Perkins DG, Cogan DG. Sliding of the epithelium in experimental corneal wounds. Invest Ophthalmol 1976;15:4–14.\nGipson IK, Danjo Y. Actin ‘purse string’ filaments are anchored by E-cadherin-mediated adherens junctions at the leading edge of the epithelial wound, providing coordinated cell movement. J Cell Sci 1998;111:3323–32.\nZhao M, Song B, Pu J, Forrester JV, McCaig CD. Direct visualization of a stratified epithelium reveals that wounds heal by unified sliding of cell sheets. Faseb J 2003;17:397–406.\nTanner K, Ferris DR, Lanzano L, Mandefro B, Mantulin WW, Gardiner DM, et al. Coherent movement of cell layers during wound healing by image correlation spectroscopy. Biophys J 2009;97:2098–106.\nSchmidt M, Paes K, De Maziere A, Smyczek T, Yang S, Gray A, et al. EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development 2007;134:2913–23.\nSainson RC, Aoto J, Nakatsu MN, Holderfield M, Conn E, Koller E, et al. Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. Faseb J 2005;19:1027–9.\nGerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003;161:1163–77.\nHellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007;445:776–80.\nGiampieri S, Manning C, Hooper S, Jones L, Hill CS, Sahai E. Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol 2009;11:1287–96.\nFriedl P, Hegerfeldt Y, Tusch M. Collective cell migration in morphogenesis and cancer. Int J Dev Biol 2004;48:441–9.\nFriedl P, Noble PB, Walton PA, Laird DW, Chauvin PJ, Tabah RJ, et al. Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro. Cancer Res 1995;55:4557–60.\nNabeshima K, Inoue T, Shimao Y, Kataoka H, Koono M. Cohort migration of carcinoma cells: Differentiated colorectal carcinoma cells move as coherent cell clusters or sheets. Histol Histopathol 1999;14:1183–97.\nChristiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 2006;66:8319–26.\nAlexander S, Koehl GE, Hirschberg M, Geissler EK, Friedl P. Dynamic imaging of cancer growth and invasion: A modified skin-fold chamber model. Histochem Cell Biol 2008;130:1147–54.\nSaez A, Anon E, Ghibaudo M, du Roure O, Di Meglio JM, Hersen P, et al. Traction forces exerted by epithelial cell sheets. J Phys Condens Matter 2010;22:194119.\nTambe DT, Hardin CC, Angelini TE, Rajendran K, Park CY, Serra-Picamal X, et al. Collective cell guidance by cooperative intercellular forces. Nat Mater 2011;10:469–75.\nLu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004;432:179–86.\nUnoki N, Murakami T, Nishijima K, Ogino K, van Rooijen N, Yoshimura N. SDF-1\u002FCXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis. Invest Ophthalmol Vis Sci 2010;51:3362–71.\nSingh R, Lei P, Andreadis ST. PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering. Exp Cell Res 2009;315:2899–913.\nFram ST, Wells CM, Jones GE. HGF-induced DU145 cell scatter assay. Methods Mol Biol 2011;769:31–40.\nLi L, Gu W, Du J, Reid B, Deng X, Liu Z, et al. Electric fields guide migration of epidermal stem cells and promote skin wound healing. Wound Repair Regen 2012;20:840–51.\nTrepat X, Wasserman MR, Angelini TE, Millet E, Weitz DA, Butler JP, et al. Physical forces during collective cell migration. Nat Phys 2009;5:426–30.",{"EN":320},"During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration. During such migration, cells move as coherent groups, large cell sheets, strands or tubes rather than individually. One unexpected finding regarding collective cell migration is that being a “multicellular structure” enables cells to better respond to chemical and physical cues, when compared with isolated cells. This is important because epithelial cells heal wounds via the migration of large sheets of cells with tight intercellular connections. Recent studies have gained some mechanistic insights that will benefit the clinical understanding of wound healing in general. In this review, we will briefly introduce the role of collective cell migration in wound healing, regeneration and cancer invasion and discuss its underlying mechanisms as well as implications for wound healing.",{"EN":322},"Collective cell migration: Implications for wound healing and cancer invasion",{"VOID":324},"10.4103\u002F2321-3868.113331","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002F1\u002F1\u002F2321-3868.113331\u002F5649316",[327,352,364,376],{"id":328,"sortIndex":19,"researcher":18,"roles":329,"affiliations":330,"properties":349},"cbb31a42-34b0-4856-bc3d-ea05ed4840e2",[192],[331,341],{"id":332,"sortIndex":222,"affiliation":333,"properties":340},"3764a2ea-01ff-4571-bfaa-cdd10f4e169a",{"id":334,"createTime":335,"updateTime":335,"relativeEntities":336,"slug":18,"properties":337,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"b3324ba7-58e3-430c-a088-0e5b3715add1","2024-01-10T22:04:48.839+00:00",[],{"title":338},{"VI":339},"State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, P.R. China",{},{"id":18,"sortIndex":19,"affiliation":342,"properties":18},{"id":343,"createTime":344,"updateTime":344,"relativeEntities":345,"slug":18,"properties":346,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"ae5fe286-fc7f-4d99-9180-24aa4124b419","2024-01-10T22:04:48.796+00:00",[],{"title":347},{"VI":348},"Department of Respiratory Diseases, Daping Hospital, Third Military Medical University, Chongqing",{"title":350},{"VI":351},"Li Li",{"id":353,"sortIndex":222,"researcher":18,"roles":354,"affiliations":355,"properties":361},"7f0245a7-1af5-461e-95d2-182693ad2987",[192],[356],{"id":18,"sortIndex":19,"affiliation":357,"properties":18},{"id":343,"createTime":344,"updateTime":344,"relativeEntities":358,"slug":18,"properties":359,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":360},{"VI":348},{"title":362},{"VI":363},"Yong He",{"id":365,"sortIndex":144,"researcher":18,"roles":366,"affiliations":367,"properties":373},"d030dccc-05a9-430b-bf82-77c55f3c67f7",[192],[368],{"id":18,"sortIndex":19,"affiliation":369,"properties":18},{"id":334,"createTime":335,"updateTime":335,"relativeEntities":370,"slug":18,"properties":371,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":372},{"VI":339},{"title":374},{"VI":375},"Jianxin Jiang",{"id":377,"sortIndex":262,"researcher":18,"roles":378,"affiliations":379,"properties":388},"1e62889a-4c57-464b-9916-3d24a5324f67",[192],[380],{"id":18,"sortIndex":19,"affiliation":381,"properties":18},{"id":382,"createTime":383,"updateTime":383,"relativeEntities":384,"slug":18,"properties":385,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"98eea823-f9a0-4ad0-982c-ef735cddb0b8","2024-01-10T22:04:48.828+00:00",[],{"title":386},{"VI":387},"Department of Dermatology, Institute for Regenerative Cures, University of California, Davis, USA",{"title":389},{"VI":390},"Min Zhao",{"url":325,"publisher":392,"properties":419},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":393,"slug":10,"properties":394,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":397,"manageAffiliations":398,"indexDatabases":399,"url":18,"thumbnailPath":18,"statistic":414,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":395,"title":396},{"VOID":13},{"EN":15},[],[],[400,407],{"id":94,"indexDatabase":401,"url":107,"indexYears":108,"academicFieldIds":406,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":402,"label":403,"description":404,"key":104,"publicationTags":405,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":408,"url":18,"indexYears":18,"academicFieldIds":413,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":409,"label":410,"description":411,"key":128,"publicationTags":412,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":415,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":416,"totalCitation":151,"totalCitationByYear":417,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":418,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":420,"pages":422},{"VOID":421},"1",{"VOID":423},"21-26","2013-06-18",2013,{"id":427,"createTime":428,"updateTime":429,"relativeEntities":430,"slug":431,"properties":432,"entityType":183,"verifyStatus":184,"verifyTime":429,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":441,"fullTextUrl":18,"authors":442,"publicationType":273,"publisherRelationship":497,"citationCount":18,"citationInfo":18,"publishDate":530,"publishYear":531,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"4fe44b39-f23d-4f44-a47f-fc53254e2d6e","2024-01-18T10:06:05.819+00:00","2025-01-29T23:48:05.320+00:00",[],"Intestinal-barrier-dysfunction-in-severe-burn-injury",{"references":433,"abstract":435,"title":437,"doi":439},{"VOID":434},"Ziegler TR, Smith RJ, O’Dwyer ST, Demling RH, Wilmore DW. Increased intestinal permeability associated with infection in burn patients. Arch Surg. 1988;123:1313–9.\nDe-Souza DA, Greene LJ. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit Care Med. 2005;33:1125–35.\nAl-Ghoul WM, Khan M, Fazal N, Sayeed MM. Mechanisms of postburn intestinal barrier dysfunction in the rat: roles of epithelial cell renewal, E-cadherin, and neutrophil extravasation. Crit Care Med. 2004;32:1730–9.\nKraehenbuhl JP, Pringault E, Neutra M. Intestinal epithelia and barrier functions. Aliment Pharmacol Ther. 1997;11(3):3–8.\nTurner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9(11):799–809.\nMarchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. Annu Rev Pathol-Mech. 2010;5:119–44.\nCecilia Berin M, Li H, Sperber K. Antibody-mediated antigen sampling across intestinal epithelial barriers. Ann N Y Acad Sci. 2006;1072:253–61.\nFink MP. Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness. Curr Opin Crit Care. 2003;9(2):143–51.\nGonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins. Prog Biophys Mol Biol. 2003;81:1–44.\nCereijido M, Contreras RG, Flores-Bentez D, Flores-Maldonado C, Larre I, Ruiz A, et al. New diseases derived or associated with the tight junction. Arch Med Res. 2007;38:465–78.\nShen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol. 2011;73:283–309.\nFuruse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol. 1993;123(6):1777–88.\nSchneeberger EE, Lynch RD. The tight junction: a multifunctional complex. Am J Physiol Cell Physiol. 2004;286(6):C1213–28.\nFeldman GJ, Mullin JM, Ryan MP. Occludin: structure, function and regulation. Adv Drug Deliv Rev. 2005;57(6):883–917.\nBuschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, et al. Occludin OCEL domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell. 2013;24(19):3056–68.\nVan Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Rev Physiol. 2006;68(1):403–29.\nBücker R, Schumann M, Amasheh S, Schulzke JD. Claudins in intestinal function and disease. Curr Top Membr. 2010;65:195–227.\nLu Z, Ding L, Lu Q, Chen YH. Claudins in intestines: distribution and functional significance in health and diseases. Tissue Barriers. 2013;1(3):e24978.\nSmalley KS, Brafford P, Haass NK, Brander JM, Brown E, Herlyn M. Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. Am J Pathol. 2005;166(5):1541–54.\nUmeda K, Ikenouchi J, Katahira-Tayama S, Furuse K, Sasaki H, Nakayama M, et al. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell. 2006;126(4):741–54.\nShin K, Margolis B. ZOning out tight junctions. Cell. 2006;126(4):647–9.\nFasano A. Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. Am J Pathol. 2008;173(5):1243–52.\nVan Itallie CM, Fanning AS, Bridges A, Anderson JM. ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell. 2009;20(17):3930–40.\nBazzoni G. Pathobiology of junctional adhesion molecules. Antioxid Redox Signal. 2011;15:1221–34.\nLuissint AC, Nusrat A, Parkos CA. JAM-related proteins in mucosal homeostasis and inflammation. Semin Immunopathol. 2014;36(2):211–26.\nChen CL, Liu YL, Wang P, Sun W, Wang FJ. Role of MLC phosphorylation in intestinal epithelial barrier dysfunction induced by severe burn injury. Acta Academ Med Milit Tert. 2008;30(15):1434–7.\nLiu YL, Wang FJ, Chen CL, Wang P. Increased intestinal permeability in severely burnt rats: regulatory mechanism of Rho kinase. Acta Academ Med Milit Tert. 2008;30(9):817–9.\nPeterson CY, Costantini TW, Loomis WH, Putnam JG, Wolf P, Bansal V, et al. Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury. Surg Infect. 2010;11(2):137–44.\nYang XK, Chen J, Bai H, Tao K, Zhou Q, Hou HY, et al. Inhibition of Na+\u002FH+ exchanger 1 by cariporide reduces burn-induced intestinal barrier breakdown. Burns. 2013;39(8):1557–64.\nWang FJ. Research on intestinal tight junction barrier dysfunction should be emphasized in burn injury. Chin J Burns. 2010;26(5):331–3.\nAudra C, Imran J, Madni T, Wolf SE. Nutrition and metabolism in burn patients. Burns & Trauma. 2017;5:11.\nDeitch EA. Intestinal permeability is increased in burn patients shortly after injury. Surgery. 1990;77(107):411–6.\nEpstein MD, Tchervenkov JI, Alexander JW, Johnson JR, Vester JW. Increased gut permeability following burn trauma. Arch Surg. 1991;126(2):198–200.\nXiao GX. The gut-origin infection in severe bums. Chin J Burns. 2008;24(5):331–3.\nHuang YL, Feng YH, Wang Y, Wang P, Wang FJ, Ren H. Severe burn-induced intestinal epithelial barrier dysfunction is associated with endoplasmic reticulum stress and autophagy in mice. Front Physiol. 2018;9:441.\nCostantini TW, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, et al. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009;66(1):17–25.\nCostantini TW, Eliceiri BP, Peterson CY, Loomis WH, Putnam JG, Baird A, et al. Quantitative assessment of intestinal injury using a novel in vivo, near-infrared imaging technique. Mol Imaging. 2010;9(1):30–9.\nCollins SM. Stress and the gastrointestinal tract IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance. Am J Phys. 2001;280:G315–8.\nBuret AG. How stress induces intestinal hypersensitivity. Am J Pathol. 2006;168(1):3–5.\nFerrier L, Mazelin L, Cenac N, Desreumaux P, Janin A, Emilie D, et al. Stress-induced disruption of colonic epithelial barrier: role of interferon-γ and myosin light chain kinase in mice. Gastroenterology. 2003;125(3):795–804.\nDemaude J, Salvador-Cartier C, Fioramonti J, Ferrier L, Bueno L. Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction. Gut. 2006;55(5):655–61.\nSun Z, Wang X, Deng X, Lasson A, Wallén R, Hallberg E, et al. The influence of intestinal ischemia and reperfusion on bidirectional intestinal barrier permeability, cellular membrane integrity, proteinase inhibitors, and cell death in rats. Shock. 1998;10(3):203–12.\nWattanasirichaigoon S, Menconi MJ, Delude RL, Fink MP. Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats. Shock. 1999;12(2):127–33.\nDrewe J, Beglinger C, Fricker G. Effect of ischemia on intestinal permeability of lipopolysaccharides. Eur J Clin Investig. 2001;31(2):138–44.\nThuijls G, de Haan JJ, Derikx JP, Daissormont I, Hadfoune M, Heineman E, et al. Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock. Shock. 2009;31(2):164–9.\nCostantini TW, Loomis WH, Putnam JG, Drusinsky D, Deree J, Choi S, et al. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins. Shock. 2009;31(4):416–22.\nWang P, Chen CL, Li M, Wang FJ. The role myosin light chain kinase in intestinal barrier dysfunction due to hypoxia. Chin J Burns. 2009;25(1):57–60.\nBanan A, Zhang LJ, Farhadi A, Fields JZ, Shaikh M, Forsyth CB, et al. Critical role of the atypical λ isoform of protein kinase C (PKC-λ) in oxidant-induced disruption of the microtubule cytoskeleton and barrier function of intestinal epithelium. J Pharmacol Exp Ther. 2005;312(2):458–71.\nInoue K, Oyamada M, Mitsufuji S, Okanoue T, Takamatsu T. Different changes in the expression of multiple kinds of tight-junction proteins during ischemia-reperfusion injury of the rat ileum. Acta Histochem Cytochem. 2006;39(2):35–45.\nLi Q, Zhang Q, Wang C, Liu X, Qu L, Gu L, et al. Altered distribution of tight junction proteins after intestinal ischaemia\u002Freperfusion injury in rats. J Cell Mol Med. 2009;13(9B):4061–76.\nFinnerty CC, Herndon DN, Chinkes DL, Jeschke MG. Serum cytokine differences in severely burned children with and without sepsis. Shock. 2007;27(1):4–9.\nUtech M, Ivanov AI, Samarin SN, Bruewer M, Turner JR, Mrsny RJ, et al. Mechanism of IFN-γ-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell. 2005;16(10):5040–52.\nWang FJ, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, et al. IFN-γ-induced TNFR2 up-regulation is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology. 2006;131(4):1153–63.\nScharl M, Paul G, Barrett KE, McCole DF. Adenosine monophosphate activated protein kinase mediates the interferon gamma-induced decrease in intestinal epithelial barrier function. J Biol Chem. 2009;284(41):27952–63.\nMcKay DM, Watson JL, Wang A, Caldwell J, Prescott D, Ceponis PMJ, et al. Phosphatidylinositol 3′-kinase is a critical mediator of interferon-γ-induced increases in enteric epithelial permeability. J Pharmacol Exp Ther. 2007;320(3):1013–22.\nClayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest. 2006;116(10):2682–94.\nMarchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR II, et al. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol. 2010;189(1):111–26.\nFischer A, Gluth M, Pape UF, Wiedenmann B, Theuring F, Baumgart DC. Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF on tight junction proteins and signaling pathways in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2013;304(11):970–9.\nFeng Y, Teitelbaum DH. TNF-α-induced loss of intestinal barrier function requires TNFR1 and TNFR2 signaling in a mouse model of total parenteral nutrition. J Physiol. 2013;591(15):3709–23.\nYe D, Ma TY. Cellular and molecular mechanisms that mediate basal and tumor necrosis factor-α induced regulation of myosin light chain kinase gene activity. J Cell Mol Med. 2008;12(4):1331–46.\nWang FJ, Graham WV, Wang YM, Witkowski ED, Schwarz BT, Turner JR. Interferon-γ and tumor necrosis factor-α synergize to induce intestinal epithelial barrier dysfunction by upregulating myosin II regulatory light chain kinase expression. Am J Pathol. 2005;166(2):409–19.\nGraham WV, Wang FJ, Clayburgh DR, Cheng JX, Yoon B, Wang Y, et al. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events: characterization of the human long myosin light chain kinase promoter. J Biol Chem. 2006;281(36):26205–15.\nLiu H, Li M, Wang P, Wang FJ. Blockade of hypoxia-inducible factor-1α by YC-1 attenuates interferon-γ and tumor necrosis factor-α-induced intestinal epithelial barrier dysfunction. Cytokine. 2011;56(3):581–8.\nLiu H, Wang P, Cao M, Li M, Wang FJ. Protective role of oligomycin against intestinal epithelial barrier dysfunction caused by IFN-γ and TNF-α. Cell Physiol Biochem. 2012;29(5-6):799–808.\nSchwarz BT, Wang FJ, Shen L, Clayburgh DR, Su L, Wang Y, et al. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 2007;132(7):2383–94.\nAl-Sadi RM, Ma TY. IL-1β causes an increase in intestinal epithelial tight junction permeability. J Immunol. 2007;178(7):4641–9.\nAl-Sadi R, Ye D, Dokladny K, Ma TY. Mechanism of IL-1β-induced increase in intestinal epithelial tight junction permeability. J Immunol. 2008;180(8):5653–61.\nAl-Sadi R, Ye D, Said HM, Ma TY. IL-1β-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-κB pathway. Am J Pathol. 2010;177(5):2310–22.\nAl-Sadi R, Guo S, Dokladny K, Smith MA, Ye D, Kaza A, et al. Mechanism of interleukin-1β iInduced-increase in mouse intestinal permeability in vivo. J Interf Cytok Res. 2012;32(10):474–84.\nAl-Sadi R, Ye D, Said HM, Ma TY. Cellular and molecular mechanism of interleukin-1β modulation of CACO-2 intestinal epithelial tight junction barrier. J Cell Mol Med. 2011;15(4):970–82.\nAl-Sadi R, Guo S, Ye D, Dokladny K, Alhmoud T, Ereifej L, et al. Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation. J Immunol. 2013;190(12):6596–606.\nDi Leo V, Yang PC, Berin MC, Perdue MH. Factors regulating the effect of IL-4 on intestinal epithelial barrier function. Int Arch Allergy Immunol. 2002;129(3):219–27.\nYang R, Han X, Uchiyama T, Watkins SK, Yaguchi A, Delude RL, et al. IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol. 2003;285(3):G621–9.\nWang Q, Fang CH, Hasselgren PO. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol. 2001;281(3):R1013–23.\nSuzuki T, Yoshinaga N, Tanabe S. IL-6 regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem. 2011;286(36):31263–71.\nWang L, Srinivasan S, Theiss AL, Merlin D, Sitaraman SV. Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations. J Biol Chem. 2007;282(11):8219–27.\nZahs A, Bird MD, Ramirez L, Choudhry MA, Kovacs EJ. Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation following binge ethanol exposure and burn injury. Shock. 2013;39(4):373–9.\nWeber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, et al. Epithelial myosin light chain kinase activation induces interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem. 2010;285(16):12037–46.\nShimizu K, Oqura H, Asahara T, Nomoko K, Matsushima A, Hayakawa K, et al. Gut microbiota and environment in patients with major burns-a preliminary report. Burns. 2015;41(3):e28–33.\nEarley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, et al. Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation. PLoS One. 2015;10(7):e0129996.\nFeng YH, Huang YL, Wang Y, Wang P, Wang FJ. Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice. Burns & Trauma. 2019;7:in press. https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs41038-019-0156-1.\nMcNamara BP, Koutsouris A, O’Connell CB, Nougayrede JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J Clin Invest. 2001;107:621–9.\nGuttman JA, Finlay BB. Tight junctions as targets of infectious agents. Biochim Biophys Acta. 2009;1788(4):832–41.\nLong TM, Nisa S, Donnenberg MS, Hassel BA. Enteropathogenic Escherichia coli inhibits type I interferon- and RNase L-mediated host defense to disrupt intestinal epithelial cell barrier function. Infect Immun. 2014;82(7):2802–14.\nShifflett DE, Clayburgh DR, Koutsouris A, Turner JR, Hecht GA. Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo. Lab Investig. 2005;85:1308–24.\nZhang Q, Li Q, Wang C, Li N, Li J. Redistribution of tight junction proteins during EPEC infection in vivo. Inflammation. 2012;35:23–32.\nZhang Q, Li Q, Wang C, Liu X, Li N, Li J. Enteropathogenic Escherichia coli changes distribution of occludin and ZO-1 in tight junction membrane microdomains in vivo. Microb Pathog. 2010;48(1):28–34.\nYuhan R, Koutsouris A, Savkovic SD, Hecht G. Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. Gastroenterology. 1997;113(6):1873–82.\nMorampudi V, Conlin VS, Dalwadi U, Wu X, Marshall KC, Nguyen C, et al. Vasoactive intestinal peptide prevents PKCε-induced intestinal epithelial barrier disruption during EPEC infection. Am J Physiol Gastrointest Liver Physiol. 2015;308(5):G389–402.\nQin H, Zhang Z, Hang X, Jiang Y. L. plantarum prevents enteroinvasive Escherichia coli-induced tight junction proteins changes in intestinal epithelial cells. BMC Microbiol. 2009;9:63.\nMoriez R, Salvador-Cartier C, Theodorou V, Fioramonti J, Eutamene H, Bueno L. Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats. Am J Pathol. 2005;167(4):1071–9.\nSheth P, Santos ND, Seth A, LaRusso NF, Rao RK. Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2007;293(1):G308–18.\nFeng YH, Wang Y, Wang P, Huang YL, Wang FJ. Short-chain fatty acids manifest stimulative and protective effects on intestinal barrier function through the inhibition of NLRP3 inflammasome and autophagy. Cell Physiol Biochem. 2018;49(1):190–205.\nChen CL, Wang P, Su Q, Wang SL, Wang FJ. Myosin light chain kinase mediates intestinal barrier disruption following burn injury. PLoS One. 2012;7(4):e34946.\nSamonte VA, Goto M, Ravindranath TM, Fazal N, Holloway VM, Goyal A, et al. Exacerbation of intestinal permeability in rats after a two-hit injury: burn and Enterococcus faecalis infection. Crit Care Med. 2004;32(11):2267–73.\nBlikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J. Restoration of barrier function in injured intestinal mucosa. Physiol Rev. 2007;87(2):545–64.\nSuzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci. 2013;70(4):631–59.\nTurner JR, Rill BK, Carlson SL, Carnes D, Kerner R, Mrsny RJ, et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Phys. 1997;273(4 Pt1):C1378–85.\nSomlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 2000;522:177–85.\nShen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, et al. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci. 2006;119(10):2095–106.\nBlair SA, Kane SV, Clayburgh DR, Turner JR. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Investig. 2006;86(2):191–201.\nTurner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol. 2006;169(6):1901–9.\nWu CC, Lu YZ, Wu LL, Yu LC. Role of myosin light chain kinase in intestinal epithelial barrier defects in a rat model of bowel obstruction. BMC Gastroenterol. 2010;10:39.\nGilbert S, Zhang R, Denson L, Moriggl R, Steinbrecher K, Shroyer N, et al. Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol Med. 2012;4(1):1–16.\nZahs A, Bird MD, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. Inhibition of long myosin light chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Am J Physiol Gastrointest Liver Physiol. 2012;303(6):G705–12.\nGuo M, Yuan SY, Sun C, Frederich BJ, Shen Q, McLean DL, et al. Role of non-muscle myosin light chain kinase in neutrophil-mediated intestinal barrier dysfunction during thermal injury. Shock. 2012;38(4):436–43.\nSegain JP, Raingeard de la Bletiere D, Sauzeau V, Bourreille A, Hilaret G, Cario-Toumaniantz C, et al. Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn’s disease and experimental colitis. Gastroenterology. 2003;124:1180–7.\nFlynn AN, Buret AG. Tight junctional disruption and apoptosis in an in vitro model of Citrobacter rodentium infection. Microb Pathog. 2008;45(2):98–104.\nLiu YL, Chen CL, Wang P, Wang FJ. Role of Rho kinase in regulating intestinal epithelial barrier dysfunction induced by sera from severely burned rata. J Med Postgrad. 2008;21(7):693–6.\nHaines RJ, Wang CY, Yang CGY, Eitnier RA, Wang F, Wu MH. Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn induced systemic inflammation. Am J Physiol Gastrointest Liver Physiol. 2017;313(6):G549–57.\nHuang YL, Wang Y, Feng YH, Wang P, He XC, Ren H, Wang FJ. Role of endoplasmic reticulum stress-autophagy axis in severe burn-induced intestinal tight junction barrier dysfunction in mice. Front Physiol. 2019;10:606.\nCannon AR, Akhtar S, Hammer AM, Morris NL, Javorski MJ, Li X, et al. Effects of mesalamine treatment on gut barrier integrity after burn injury. J Burn Care Res. 2016;37(5):283–92.\nCostantini TW, Peterson CY, Kroll L, Loomis WH, Eliceiri BP, Baird A, et al. Role of p38 MAPK in burn-induced intestinal barrier breakdown. J Surg Res. 2009;156(1):64–9.\nGraham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, et al. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nat Med. 2019;25(4):690–700.",{"EN":436},"Severe burn injury is often accompanied by intestinal barrier dysfunction, which is closely associated with post-burn shock, bacterial translocation, systemic inflammatory response syndrome, hypercatabolism, sepsis, multiple organ dysfunction syndrome, and other complications. The intestinal epithelium forms a physical barrier that separates the intestinal lumen from the internal milieu, in which the tight junction plays a principal role. It has been well documented that after severe burn injury, many factors such as stress, ischemia\u002Fhypoxia, proinflammatory cytokines, and endotoxins can induce intestinal barrier dysfunction via multiple signaling pathways. Recent advances have provided new insights into the mechanisms and the therapeutic strategies of intestinal epithelial barrier dysfunction associated with severe burn injury. In this review, we will describe the current knowledge of the mechanisms involved in intestinal barrier dysfunction in response to severe burn injury and the emerging therapies for treating intestinal barrier dysfunction following severe burn injury.",{"EN":438},"Intestinal barrier dysfunction in severe burn injury",{"VOID":440},"10.1186\u002Fs41038-019-0162-3","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002Fdoi\u002F10.1186\u002Fs41038-019-0162-3\u002F5685878",[443,458,473,485],{"id":444,"sortIndex":262,"researcher":18,"roles":445,"affiliations":446,"properties":455},"b555e31b-7cd2-4d88-94c4-880d18977a66",[192],[447],{"id":18,"sortIndex":19,"affiliation":448,"properties":18},{"id":449,"createTime":450,"updateTime":450,"relativeEntities":451,"slug":18,"properties":452,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"18f49702-fa20-48c5-9c36-bec0147edcf3","2024-02-07T03:22:06.258+00:00",[],{"title":453},{"VI":454},"State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China",{"title":456},{"VI":457},"Pei Wang",{"id":459,"sortIndex":222,"researcher":18,"roles":460,"affiliations":461,"properties":470},"492ac7bf-d412-489e-b1ab-e3e674ad2729",[192],[462],{"id":18,"sortIndex":19,"affiliation":463,"properties":18},{"id":464,"createTime":465,"updateTime":465,"relativeEntities":466,"slug":18,"properties":467,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"6bd54174-0de5-4363-a5c7-ff9682d8ab5c","2024-01-18T10:06:05.841+00:00",[],{"title":468},{"VI":469},"Department of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China",{"title":471},{"VI":472},"Yu Wang",{"id":474,"sortIndex":144,"researcher":18,"roles":475,"affiliations":476,"properties":482},"69ce0fe2-52e7-48bf-9fca-cfa0c2786d0a",[192],[477],{"id":18,"sortIndex":19,"affiliation":478,"properties":18},{"id":449,"createTime":450,"updateTime":450,"relativeEntities":479,"slug":18,"properties":480,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":481},{"VI":454},{"title":483},{"VI":484},"Fengjun Wang",{"id":486,"sortIndex":19,"researcher":18,"roles":487,"affiliations":488,"properties":494},"56e4698a-db18-4d9d-be02-e75bb59f90c1",[192],[489],{"id":18,"sortIndex":19,"affiliation":490,"properties":18},{"id":449,"createTime":450,"updateTime":450,"relativeEntities":491,"slug":18,"properties":492,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":493},{"VI":454},{"title":495},{"VI":496},"Wen He",{"url":441,"publisher":498,"properties":525},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":499,"slug":10,"properties":500,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":503,"manageAffiliations":504,"indexDatabases":505,"url":18,"thumbnailPath":18,"statistic":520,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":501,"title":502},{"VOID":13},{"EN":15},[],[],[506,513],{"id":94,"indexDatabase":507,"url":107,"indexYears":108,"academicFieldIds":512,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":508,"label":509,"description":510,"key":104,"publicationTags":511,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":514,"url":18,"indexYears":18,"academicFieldIds":519,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":515,"label":516,"description":517,"key":128,"publicationTags":518,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":521,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":522,"totalCitation":151,"totalCitationByYear":523,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":524,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":526,"pages":528},{"VOID":527},"7",{"VOID":529},"1-11","2019-07-26",2019,{"id":533,"createTime":534,"updateTime":535,"relativeEntities":536,"slug":537,"properties":538,"entityType":183,"verifyStatus":184,"verifyTime":535,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":547,"fullTextUrl":18,"authors":548,"publicationType":273,"publisherRelationship":593,"citationCount":18,"citationInfo":18,"publishDate":625,"publishYear":308,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"3a5734a6-c553-4515-8682-54c706195182","2024-01-25T23:24:55.010+00:00","2024-12-10T23:34:15.757+00:00",[],"The-evidence-for-natural-therapeutics-as-potential-anti-scarring-agents-in-burn-related-scarring",{"references":539,"abstract":541,"title":543,"doi":545},{"VOID":540},"World Health Organization http:\u002F\u002Fwww.who.int\u002Fmediacentre\u002Ffactsheets\u002Ffs365\u002Fen\u002F Accessed 5th Jan 2016\nAmerican Burn Association. http:\u002F\u002Fameriburn.org\u002Fresources_factsheet.php accessed 9th Jul 2015\nWHO http:\u002F\u002Fwww.who.int\u002Fviolence_injury_prevention\u002Fother_injury\u002Fburns\u002Fen\u002F Accessed 9th Jul 2015\nSheridan RL. Burn care: results of technical and organizational progress. JAMA. 2003;290:719–22.\nSinger AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738–46.\nGauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies. Mol Med. 2011;17(1–2):113–25.\nDeitch EA, Wheelahan TM, Rose MP, Clothier J, Cotter J. Hypertrophic burn scars: analysis of variables. J Trauma. 1983;23:895–8.\nMcDonald WS, Deitch EA. Hypertrophic skin grafts in burned patients: a prospective analysis of variables. J Trauma. 1987;27:147–50.\nSpurr ED, Shakespeare PG. Incidence of hypertrophic scarring in burn-injured children. Burns. 1990;16:179–81.\nDedovic Z, Koupilova I, Brychta P. Time trends in incidence of hypertrophic scarring in children treated for burns. Acta Chir Plast. 1999;41(3):87–90.\nBombaro KM, Engrav LH, Carrougher GJ, Wiechman SA, Faucher L, Costa BA, et al. What is the prevalence of hypertrophic scarring following burns? Burns. 2003;9:299–302.\nGangemi EN, Gregori D, Berchialla P, Zingarelli E, Cairo M, Bollero D, et al. Epidemiology and the risk factors for pathological scarring after burn wounds. Arch Facial Plast Surg. 2008;10:93–102.\nSchneider JC, Holvanahalli R, Helm P, Goldstein R, Kowalske K. Contractures in burn injury; defining the problem. J Burn Care Res. 2006;27:508–14.\nTredget EE. Pathophysiology and treatment of fibroproliferative disorders following thermal injury. Ann N Y Acad Sci. 1999;888:165–82.\nAli SS, Hajrah NH, Ayuob NN, Moshref SS, Abuzinadah OA. Morphological and morphometric study of cultured fibroblast from treated and untreated abnormal scar. Saudi Med J. 2010;30:874–81.\nSchmid P, Itin P, Bi C, Cox DA. Enhanced expression of transforming growth factor- beta type I and type II receptors in wound granulation tissue and hypertrophic scar. Am J Pathol. 1998;15(2):485–93.\nWang R, Ghahary A, Shen Q, Scott PG, Roy K, Tredget EE. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor- beta 1 mRNA and protein than normal skin and cells. Wound Repair and Regen. 2000;8:128–37.\nXie JL, Qi SH, Pan S, Xu YB, Li TZ, Liu XS, et al. Expression of Smad proteins by normal skin fibroblasts and hypertrophic scar fibroblasts in response to transforming growth factor beta 1. Dermatol Surg. 2008;34:1216–24.\nKopp J, Preis E, Said H, Hafemann B, Wickert L, Gressner AM, et al. Abrogation of transforming growth factor-B signalling by SMAD 7 inhibits collagen gel contraction of human dermal fibroblasts. J Biol Chem. 2006;22(3):21570–6.\nAshcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol. 1999;1(5):260–6.\nSumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Ogawa H. Exogenous Smad3 accelerates wound healing in a rabbit derma ulcer model. J Invest Dermatol. 2004;123:229–36.\nSetoguchi Y, Jaffe HA, Danel C, Cystal RG. Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors. J Invest Dermatol. 1994;102:415–21.\nScott PG, Dodd CM, Tredget EE, Ghahary A, Rahemtulla F. Chemical characterisation and quantification of proteoglycans in human post burn hypertrophic and mature scars. Clin Sci (London). 1996;90:417–25.\nZhang Z, Garron TM, Li XJ, Liu Y, Zhang X, Li YY, et al. Recombinant human decorin inhibits TGF-beta 1 induced contraction of collagen lattice by hypertrophic scar fibroblasts. Burns. 2009;35(4):527–37.\nLinge C, Richardson J, Vigor C, Clayton E, Hardas B, Rolfe K. Hypertrophic scars cells fail to undergo a form of apoptosis specific to contractile collagen- the role of transglutaminase. J Invest Dermatol. 2005;12:72–82.\nHinz B, Gabbiani G. Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling. Thromb Haemost. 2003;90(6):993–1002.\nMoulin V, Larochelle S, Langlois C, Thibault I, Lopez-Valle CA, Roy M. Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors. J Cell Physiol. 2004;198(3):350–8.\nYang L, Scott PG, Giuffre J, Shankowsky HA, Ghahary A, Tredget EE. Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest. 2002;82:1183–92.\nYang L, Scott PG, Dodd C, Medina A, Jiao H, Shankowsky HA, et al. Identification of fibrocytes in post burn hypertrophic scar. Wound Repair Regen. 2005;13(4):398–404.\nWang J, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE. Increased TGF-beta-producing CD41 T lymphocytes in post burn patients and their potential interaction with dermal fibro-blasts in hypertrophic scarring. Wound Repair Regen. 2007;15(4):530–9.\nEto H, Suga H, Aoi N, Kato H, Doi K, Kuno S, et al. Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: up regulation of MMP-1 and HGF expression. Lab Invest. 2012;92:214–23.\nNeely AN, Clendening CE, Gardner J, Greenhalgh DG, Warden GD. Gelatinase activity in keloids and hypertrophic scars. Wound Repair Regen. 1999;7(3):166–71.\nMauviel A. Cytokine regulation of metalloproteinase gene expression. J Cell Biochem. 1993;53:288–95.\nZhang Y, McCluskey K, Fuji K, Wahl LM. Differential regulation of metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte –macrophage CSF and IL-1 beta through prostaglandin dependent and independent mechanisms. J Immunol. 1998;161:3071–6.\nTredget EE, Yang L, Delehanty M, Shankowsky H, Scott PG. Polarized T helper cells Th2 cytokine production in patients with hypertrophic scar following thermal injury. J Interferon Cytokine Res. 2005;26:179–89.\nWang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, et al. Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. J Cell Physiol. 2011;226(5):1265–73.\nLiuzzi F, Chadwick S, Shah M. Paediatric post-burn scar management in the UK: A national survey. Burns. 2015;41(2):252–6.\nSidgwick GP, McGeorge D, Bayat A. A comprehensive evidence-based review on the role of topical and dressings in the management of skin scarring. Arch Dermatol Res. 2015;307:461–77.\nStewart TL, Ball B, Schembri PJ, Hori K, Ding J, Shankowsky HA, et al. The use of laser Doppler imaging as a predictor of burn depth and hypertrophic scar post burn injury. J Burn Care. 2012;33(6):764–71.\nKwan PO, Ding J, Tredget EE. Serum decorin, IL-1β and TGF-β predict hypertrophic scarring post burn. J Burn care Res. In press.\nAnzarut A, Olson J, Singh P, Rowe BH, Tredget EE. The effectiveness of pressure garment therapy for the prevention of abnormal scarring after burn injury: a meta-analysis. J Plast Reconstr Aesthet Surg. 2009;62(1):77–84.\nEngrav LH, Heimbach DM, Rivara FP, Moore ML, Wang J, Carrougher GJ, et al. 12-year within-wound study of the effectiveness of custom pressure garment therapy. Burns. 2010;36(7):975–83.\nRanò F, Grazianetti P, Stella M, Magliacani G, Pezzulto C, Cannas M. Release and activation of matrix metalloproteinase −9 during in vitro mechanical compression in hypertrophic scars. Arch Dermatol. 2002;138(4):475–8.\nCosta AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A. Mechanical forces induce scar remodelling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. Am J Pathol. 1999;155(5):1671–9.\nJohnson J, Greenspan B, Gorga D, Nagler W, Goodwin C. Compliance with pressure garment use in burn rehabilitation. J Burn Care Rehab. 1994;15(2):180–8.\nMacintyre L, Baird M. Pressure garments for use in the treatment of hypertrophic scars- a review of the problems associated with their use. Burns. 2006;32(1):10–5.\nO’Brien L, Jones DJ. Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2013;9:CD003826.\nSo K, Umraw N, Scott J, Campbell K, Musgrave M, Cartotto R. Effects of enhanced patient education on compliance with silicone gel sheeting and burn scar outcome: a randomised prospective study. J Burn Care Rehabi. 2003;24(6):411–7.\nChoi J, Lee EH, Park SW, Chang H. Regulation of Transforming growth factor β1, platelet-derived growth factor, and basic fibroblast growth factor by silicone gel sheeting in early-stage scarring. Arch Plast Surg. 2015;42(1):20–7.\nGauglitz GG. Management of keloids and hypertrophic scars: current and emerging options. Clin Cosment Investig Dermatol. 2013;6:103–14.\nRoques C, Téot L. The use of corticosteroids to treat keloids.: A review. Int J of Low Extrem Wounds. 2008;7(3):137–45.\nManuskiatti W, Fitzpatrixk RE. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585 nm flashlamp-pumped pulse dye laser treatments. Arch Dermatol. 2002;138(9):1149–55.\nTredget EE, Levi B, Donelan MB. Biology and principles of scar management and burn reconstruction. Surg Clin North Am. 2014;94(4):793–815.\nRabello FB, Souza CD, Júnior JAF. Update on hypertrophic scar treatment. Clinics. 2014;69(8):565–573.55.\nYe Q, Wang S-J, Chen J-Y, Rahman K, Hai-Liang X, Zhang H. Medicinal plants for the treatment of hypertrophic scars. Evid Based Complement Alternat Med. 2015;2015:101340.\nRoss JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr. 2002;22:19–34.\nBors W, Heller W, Michel C, Saran M. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Methods Enzymol. 1990;186:343–55.\nLamson DW, Brignall MS. Antioxidants and cancer, part 3: Quercetin. Altern Med Rev. 2000;5:196–208.\nPrior RL. Fruits and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr. 2003;78:570–8S.\nWilliams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med. 2004;36(7):838–49.\nBarnes S, Prasain J, D’Alessandro T, Arabshahi A, Botting N, Lila MA, et al. The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. Food Function. 2011;2(5):235.\nPhan TT, Lim IJ, Chan SY, Tan EK, Lee ST, Longaker MT. Suppression of transforming growth factor beta\u002Fsmad signalling in keloid derived fibroblasts by querectin; implications for the treatment of excessive scars. J Trauma. 2004;57(5):1032–7.\nPhan TT, Sun L, Tran E, Nguyen TT, Chan SY, Lee ST, et al. Suppression of insulin like growth factor signalling pathway and collagen expression in keloid derived fibroblasts by quercetin: its therapeutic potential use in the treatment and\u002For prevention of keloids. Br J Dermatol. 2003;148(3):544–52.\nLong X, Zeng X, Zhang FQ. Influence of quercetin and xray on collagen synthesis of cultured human keloid fibroblasts. Chin Med Sci J. 2006;21(3):179–83.\nPhan TT, Sun L, Bay BH, Chan SY, Lee ST. Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar derived fibroblasts in vitro: therapeutic implications for excessive scarring. J Trauma. 2003;54(6):1212–24.\nSaulis AS, Mogford JH, Mustoe TA. Effect of Mederma on hypertrophic scarring in the rabbit ear model. Plast Recontr Surg. 2002;110(1):177–83.\nAugusti T. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian J Exp Biol. 1996;34(7):634–40.\nCho J-W, Cho S-Y, Lee S-R, Lee K-S. Onion extract and quercetin induce matrix metalloproteinase −1 in vitro and in vivo. Int J Mol Med. 2010;25:347–52.\nChanprapaph K, Tanrattanakorn S, Wattanakrai P, et al. Effectiveness of onion extract gel on surgical scars in Asians. Dermatol Res Pract. 2012;2012:212945.\nHo WS, Ying SY, Chan PC, Chan HH. Use of onion extract, heparin, allantoin gel in prevention of scarring in Chinese patients having laser removal of tattoos: A prospective randomized controlled trial. Dermatol Surg. 2006;32(7):891–6.\nWananukul S, Chatpreodprai S, Peongsujarit D, Lertsapcharoen P. A prospective placebo-controlled study on the efficacy of onion extract in silicone derivative gel for the prevention of hypertrophic scar and keloid in median sternotomy wound in pediatric patients. J Med Assoc Thai. 2013;96(11):1428–33.\nJenwitheesuk K, Surakunprapha P, Jenwitheesuk K, Kuptamond C, Prathanee S, Intanoo W. Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial. Int Wound J. 2012;9:397–402.\nBeuth J, Hunzelmann N, van Leendert R, Basten R, Noehle M, Schenider B. Safety and Efficacy of Local Administration of Contractubex® to Hypertrophic Scars in Comparison to Corticosteroid Treatment. Results of a Multicenter, Comparative Epidemiological Cohort Study in Germany. In vivo. 2006;20:277–84.\nGeorge J, Singh M, Srivastava AK, Bhui K, Roy P, Chaturvedi PK, et al. Resveratrol and Black Tea Polyphenol Combination Synergistically Suppress Mouse Skin Tumors Growth by Inhibition of Activated MAPKs and p53. PLoS ONE. 2011;6:e23395.\nHiroto Y, Tadokoro K, Tsuda T, Nakazono E, Ohnaka K, Takayanagi R, et al. Resveratrol, a phytoestrogen found in red wine, down-regulates protein S expression in HepG2 cells. Thrombo Res. 2011;127:e1–7.\nOlson ER, Naugle JE, Zhang X, Bomser JA, Meszaros JG. Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol. Am J Physiol Heart Circ Physiol. 2005;288(3):1131–8.\nGlehr M, Fritsch-Breisach M, Lohberger B, Walzer SM, Moazedi-Fuerst F, Rinner B, et al. Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine. 2013;20(3–4):310–8.\nYao J, Wang JY, Liu L, Li YX, Xun AY, Zeng WS, et al. Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis. Arch Med Res. 2010;41(4):288–94.\nZeng G, Zhong F, Luo JL, Zhang P. Resveratrol mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. Biosci Biotechnol Biochem. 2013;77(12):2389–96.\nSogutlu G, Karabulut AB, Ara C, Cinpolat O, Isik B, Piskin T, et al. The effect of resveratrol on surgery induced peritoneal adhesions in an experimental model. Cell Biochem Funct. 2007;25(2):217–20.\nIkeda K, Torigoe T, Matsumoto Y, Fujita T, Sato N, Yotsuyanag T. Resveratrol inhibits fibrogenesis and induces apoptosis in keloid fibroblasts. Wound Repair Regen. 2013;21:616–23.\nBranford OA, Grobbelaar AO, Rolfe KJ. Epigallocatechin-3-gallate (EGCG), a constituent of green tea and its anti-fibrotic effect. In Tea Consumption and Health Nova. 153–166.\nSuzuki Y, Hattori S, Isemura M. Epigallocatechin-3-O-gallate inhibits fibroblast contraction of floating collagen gel: Interaction between epigallocatechin-3-O-gallate and platelet derived growth factor. Biosci Biotechnol Biochem. 2004;68:1817–20.\nKlass BR, Branford OA, Grobbelaar AO, Rolfe KJ. The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-beta1-stimulated wound contraction. Wound Repair Regen. 2010;18(1):80–8.\nWeber AA, Neuhaus T, Skach RA, Hatcheller J, Ahn HY, Schrör K, et al. Mechanisms of the inhibitory effects of epigalocatechin-3 gallate on platelet –derived growth factor-BB induced cell signalling and mitogenesis. FASEB J. 2004;18:128–30.\nCai Y, Yu SS, Chen TT, Gao S, Geng B, Yu Y, et al. EGCG inhibits CTGF expression via blocking NF- κB activation in cardiac fibroblast. Phytomedicine. 2013;20(2):106–13.\nWang CY, Deng YT, Huang SY, Liu CM, Chang HH, Wong MY. Epigallocatechin-3-gallate inhibits lysophosphatidic acid-stimulated connective tissue growth factor via JNK and Smad3 suppression in human gingival fibroblasts. J Formos Med Assoc. 2014;223(1):50–5.\nMoyle CW, Cerezo AB, Winterborne MS, Hollands WJ, Alexeev Y, Needs PW, et al. Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis. Mol Nutr Food Res. 2015;59(3):401–12.\nKim H, Kawazoe T, Han DW, Matsumara K, Suzuki S, Tsutsumi S, et al. Enhanced wound healing by an epigallocatechin gallate incorporated collagen sponge in diabetic mice. Wound Repair Regen. 2008;16:714–20.\nGoo HC, Hwang YS, Choi YR, Cho HN, Suh H. Development of collagenase-resistant collagen and its interaction with adult human dermal fibroblasts. Biomaterials. 2003;24:5099–113.\nYang EJ, Lee W, Ku SK, Song KS, Bae JS. Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs. Food Chem Toxicol. 2012;50(5):1288–94.\nChakravarti B, Maurya R, Siddiqui JA, Bid HK, Rajendran SM, Yadav PP, et al. In vitro anti-breast cancer activity of ethanolic extract of Wrightiato mentosa: role of pro-apoptotic effects of oleanolic acid and urosolic acid. J Ethnopharmacol. 2012;142(1):72–9.\nWei Y, Yan XQ, Ma L, Wu JG, Zhang H, Qin LP. Oleanolic acid inhibits hypertrophic scarring in the rabbit ear model. Clin Exp Dermatol. 2011;36(5):528–33.\nZhang H, Zhang Y, Jiang YP, Zhang LK, Peng C, He K, et al. Curative effects of oleanolic acid on formed hypertrophic scars in the rabbit ear model. Evid Based Complement Alternat Med. 2012;2012:2012837581.\nAtsumi T, Murakami Y, Shibuya K, Tonosaki K, Fujisawa S. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analogue, alphadiisoeugenol. Anticancer Res. 2005;25:4029–36.\nChan WH, Wu HY, Chang WH. Dosage effects of curcumin on cell death types in a human osteoblast cell line. Food Chem Toxicol. 2006;44:1362–71.\nDujic J, Kippenberger S, Hoffmann S, Ramirez-Bosca A, Miguel J, Diaz-Alperi J, et al. Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light. J Invest Dermatol. 2007;127:1992–2000.\nPanchatcharam M, Miriyala S, Gayathr VS, Suguna L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem. 2006;290:87–96.\nScharstuhl A, Mutsaers HAM, Pennings SW, Szarek WA, Russel FG, Wagener FA. Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation. J Cell Mol Med. 2009;13(4):712–25.\nWang R, Yin R, Zhou W, Xu D, Li S. Shikonin and its derivatives: a patent review. Expert Opin Ther Pat. 2012;22:977–97.\nWu Y, Fabritius MIC. Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer. Cancer Biol Ther. 2009;8:146–52.\nYang JT, Li ZL, Wu JY, Lu FJ, Chen CH. An oxidative stress mechanism of shikonin in human glioma cells. PLoS One. 2014;9:e94180.\nChang IC, Huang YJ, Chiang CW, Yeh LS. Shikonin induces apoptosis through reactive oxygen species\u002Fextracellular signal- regulated kinase pathway in osteosarcoma cells. Biol Pharm Bull. 2010;33:816–24.\nHashimoto S, Xu M, Masuda T, Aiuchi S, Nakajo J, Cao M, et al. Beta-hydroxyisoovaleryishikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60cells through a mechanism different from those of Fas and etoposide. J Biochem. 1999;125:17–23.\nGao D, Hiromura M, Yasui H, Sakurai H. Direct reaction between Shikonin and thiols induces apoptosis in HL60 cells. Biol Pharm. 2002;25:827–82.\nFan C, Xie Y, Dong Y, Su Y, Upton Z. Investigating the potential of Shikonin as a novel hypertrophic scar treatment. J Biomed Sci. 2015;22:70.\nXie Y, Fan C, Dong Y, Lynam E, Leavesley DI, Li K, et al. Functional and mechanistic investigation of Shikonin in scarring. Chemico-Bio Interact. 2015;228:18–27.\nFan C, Dong Y, Xie Y, Su Y, Zhang X, Leavesley D, et al. Shikonin reduces TGF-β1- induced collagen production and contraction in hypertrophic scar derived fibroblasts. Int J Mole Med. 2015;36:985–91.\nWang T, Zhong XG, Li YH, Zhang SJ, Gao YS, et al. Protective effect of emodin against airway inflammation in the ovlbumin-induced mouse model. Chin J Integr Med. 2015;21:431–7.\nZhu X, Zeng K, Qiu Y, Yan F, Lin C. Therapeutic effect of emodin on collagen-induced arthritis in mice. Inflammation. 2013;36:1253–9.\nSun YP, Liu JP. Blockade of emodin on amyloid-β 26-35-induced neurotoxicity in AβPP\u002FPS1 mice and PC12 cells through activation of the class III phosphatidylinositol 3-kinase\u002FBeclin-1\u002FB cells lymphoma 2 pathway. Planta Med. 2015;81:108–15.\nShirmali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Sethi G. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. Cancer Lett. 2013;341:139–49.\nLiu C. Inhibition of mechanical stress-induced hypertrophic scar inflammation by emodin. Molec Med Reports. 2015;11:4087–92.\nHu Q, Noor M, Wong YF, Hylands PJ, Simmonds MS, Xu Q, et al. In vitro anti fibrotic activities of herbal compounds and herbs. Nephrol Dial Transplant. 2009;24:3033–41.\nChen XH, Sun RS, Hu JM, Mo ZF, Yang ZF, Jin GY, et al. Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice. Clin Exp Pharmacol Physiol. 2009;36:146–53.\nDong MX, Jia Y, Zhang YB, Li CC, Geng YT, Zhou L, et al. Emodin protects rat liver from CCI(4) – induced fibrogenesis via inhibition of hepatic stellate cells activation. World J Gastroenterol. 2009;15:4753–62.\nSchepartz AI, Subers NH. Catalase in honey. J Apic Res. 1996;5:37–43.\nSubrahmanyam M. Addition of antioxidant and polyethylene glycol 4000 enhances the healing property of honey in burns. Ann Burns Fire Disasters. 1996;9:93–5.\nBrady NF, Molan PC, Harfoot CG. The sensitivity of dermatophytes to the antimicrobial activity of manuka honey and other honey. Pharm Sci. 1997;2:1–3.\nWahdan H. Causes of the antimicrobial activity of honey. Infection. 1998;26:26–31.\nLu J, Carter DA, Turnbull L, Rosendale D, Hedderley D, Stephens J, et al. The Effect of New Zealand Kanuka, Manuka and Clover Honeys on Bacterial Growth Dynamics; and Cellular Morphology Varies According to the Species. PLoS ONE. 2013;8:55898.\nRufian-Henares JA, Morales FJ. Functional properties of melanoidins: In vitro antioxidant, antimicrobial and antihypertensive activities. Food Res Int. 2007;40:995–1002.\nMavric E, Wittmann S, Barth G, Henle T. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res. 2008;52:483–9.\nKwakman PHS, teVelde AA, de Boer L, Spejer D, Vandenbroucke-Grauls CM, Zaat SA. How honey kills bacteria. FASEB J. 2010;24:2576–82.\nSubrahmanyam M, Hemmady A, Pawar SG. The sensitivity to honey of multidrug-resistant Pseudomonas Aeruginosa from infected burns. Ann Burns Fire Disasters. 2003;16:84–6.\nAbuharfeil N, Al-Oran R, Abo-Shehada M. The effect of bee honey on the proliferative activity of human B- and T-lymphocytes and the activity of phagocytes. Food Agric Immunol. 1999;11:169–77.\nTonks A, Cooper RA, Price AJ, Molan PC, Jones KP. Stimulation of TNF-alpha release in monocytes by honey. Cytokine. 2001;14:240–2.\nTonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tanks A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine. 2003;21:242–7.\nMolan PC. The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds. 2006;5:40–54.\nNakajima Y, Nakano Y, Fuwano S, Hayahi N, Kinoshita A, Miyahara M, et al. Effects of three types of Japanese honey on full thickness wound in mice. Evid Based Complement Alternat Med. 2013;2013:504537.\nGupta SS, Singh O, Bhagel PS, Moses S, Shukla S, Mathur RK. Honey dressing versus silver sulfadiazine dressing for wound healing in burn patients: a retrospective study. J Cutan Surg. 2011;4(3):183–7.\nJull AB, Rodgers A, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2008;4:CD005083.\nWasiak J, Cleland H, Campbell F. Dressings for superficial and partial thickness burns. Cochrane Database Syst Rev. 2008;8(4):CD002106.\nStorm-Versloot MN, Vos CG, Ubbink DT, Vermeulen H. Topical silver for preventing wound infection. Cochrane Database Syst Rev. 2010;17(3):CD006478.\nSubrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSiteR) in the treatment of burns – a prospective randomised study. Br J Plast Surg. 1993;46:322–3.\nSubrahmanyam M. Honey impregnated gauze versus amniotic membrane in the treatment of burns. Burns. 1994;20:331–3.\nSubrahmanyam M. A prospective randomised clinical and histopathological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998;24:157–61.\nLiu J, Lu Y-F, Zhang Y, Wu KC, Fan F, Klaassen CD. Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice. Toxicol Appl Pharmacol. 2013;272:10.1016.\nChin MP, Reisman SA, Bakris GL, O'Grady M, Linde PG, McCullough PA, et al. Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl. Am J Nephrol. 2014;39:499–508.\nChow HH, Garland LL, Heckman-Stoddard BM, Hsu CH, Butler VD, et al. A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med. 2014;12:223.\nLovera J, Ramos A, Devier D, Garrison V, Kovner B, Reza T, et al. Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies. J Neurol Sci. 2015;358:46–52.\nPillukat MH, Bester C, Hensel A, Lechtenberg M, Petereit F, Beckebaum S, et al. Concentrated green tea extract induces severe acute hepatitis in a 63-year-old woman--a case report with pharmaceutical analysis. J Ethnopharmacol. 2014;155:165–70.\nVohra S, Cvijovic K, Boon H, Foster BC, Jaeger W, LeGatt D, et al. Study of natural health product reactions (SPNAR): Active surveillance of adverse events following the concurrent natural health product and prescription use in community pharmacies. PLoS One. 2012;7(9):e45196.\nBun SS, Ciccolini J, Bun H, Aubert C, Catalin J. Drug interactions of paclitaxel metabolism in human liver microsomes. J Chemother. 2003;15:266–74.\nSak K. Chemotherapy and dietary phytocemical agents. Chem Res Practice. 2012;2012:282570.\nShang W, Lu W, Han M, Qiao J. The interactions of anticancer agents with tea catechins: current evidence from preclinical studies. Anticancer Agents Med Chem. 2014;14:1343–50.\nWang CZ, Luo X, Zhang B, Song WX, Ni M, Mehendale S, et al. Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells. Cancer Chemother Pharmacol. 2007;60:69–79.\nSen S, Sharma H, Singh N. Curcumin enhances Vinorelbine mediated apoptosis in NSCLC cells by the mitochondrial pathway. Biochem Biophys Res Commun. 2005;331:1245–52.\nBoocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev. 2007;16:1246–52.\nChen CY, Chen FA, Wu AB, Hsu HC, Kang JJ, Cheng HW. Effect of hydroxypropyl-β-cyclodextrin on the solubility, photo stability and in vitro permeability of alkannin\u002Fshikonin enantiomers. Int J Pharm. 1996;141:171–8.\nXia H, Tang C, Gui H, Wang X, Qi J, Wang X, et al. Preparation, cellular uptake and angiogenic suppression of shikonin-containing liposomes in vitro and in vivo. Biosci Rep. 2013;33:e00020.\nOlthof MR, Hollman PCH, Vree TB, Katan MB. Bioavailabilities of quercetin-3-glucoside and quercetin-4’-glucoside do not differ in humans. J Nutr. 2000;130:1200–3.\nKiesewetter H, Koscielny J, Kalus U, Vix JM, Petrini O, van Toor BS, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung. 2000;50:109–17.\nErlund I, Kosonen T, Alfthan J, Mäenpää J, Pertunen K, Kenraali J, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmaol. 2000;56:545–53.\nLombardi G, Vannini S, Blasi F, Marcotullio MC, Dominici L, Villarini M, et al. In Vitro Safety\u002FProtection Assessment of Resveratrol and Pterostilbene in a Human Hepatoma Cell Line (HepG2). Nat Prod Commum. 2015;10:1403–8.\nTurner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, et al. A randomised double-blind, placebo controlled trial of resveratrol for Alzheimer disease. Neurology. 2015;85:1383–91.\nvan der Made SM, Plat J, Mensink RP. Resveratrol does not influence metabolic risk markers related to cardiovascular health in overweight and slightly obese subjects: a randomized, placebo-controlled crossover trial. PLoS One. 2015;10:e0118393.\nJoe AK, Schnol-Sussman F, Bresailier RS, Abrams JA, Hibshoosh H, Cheung K, et al. Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus. Cancer Prev Res. 2015;8:1131–7.\nChen IJ, Liu CY, Chiu JP, Hsu CH. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2015; in press\nChow HH, Cai Y, Hamkim IA, Crowell JA, Shahi F, Brooks CA, et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res. 2003;9:3312–9.\nZhao H, Zhu W, Jia L, Sun X, Chen G, Zhao X, et al. Phase I study of topical epigallocatechin-3-gallate (EGCG) in patients with breast cancer receiving adjuvant radiotherapy. Br J Radiol. In press\nDostal AM, Samavat H, Bedell S, Trokelson C, Wang R, Swenson K, et al. The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial. Food Chem Toxicol. 2015;83:26–35.\nMdhluli MC, van der Horst G. The effect of oleanolic acid on sperm motion characteristics and fertility of male Wistar rats. Lab Anim. 2002;36:432–7.\nCheng AL, Hsu CH, Lin CH, et al. Phase I clinical trial of curcumin, a chemo preventative agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21:2895–900.\nGoeal A, Kunnumakkara AB, Aggarwal BB. Curcumin as ‘Curemin’: from kitchen to clinic. Biochem Pharmacol. 2008;75:787–809.\nJiao Y, Wilkinson J, Di X, Wang W, Hatcher H, Kock ND, et al. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2009;113:462–9.\nAlbreht A, Vovk I, Simonovska B. Addition of β-lactoglobulin produces water-soluble shikonin. J Agric Food Chem. 2012;60:10834–43.\nSu L, Liu L, Wang Y, Yan G, Zhang Y. Long-term systemic toxicity of shikonin derivatives in Wistar rats. Pharm Biol. 2014;52:486–90.\nSimon A, Traynor K, Santos K, Blaser G, Bode U, Molan P. Medical Honey for Wound Care—Still the ‘Latest Resort’? Evid Based Complement Alternat Med. 2009;6:165–73.",{"EN":542},"Though survival rate following severe thermal injuries has improved, the incidence and treatment of scarring have not improved at the same speed. This review discusses the formation of scars and in particular the formation of hypertrophic scars. Further, though there is as yet no gold standard treatment for the prevention or treatment of scarring, a brief overview is included. A number of natural therapeutics have shown beneficial effects both in vivo and in vitro with the potential of becoming clinical therapeutics in the future. These natural therapeutics include both plant-based products such as resveratrol, quercetin and epigallocatechin gallate as examples and includes the non-plant-based therapeutic honey. The review also includes potential mechanism of action for the therapeutics, any recorded adverse events and current administration of the therapeutics used. This review discusses a number of potential ‘treatments’ that may reduce or even prevent scarring particularly hypertrophic scarring, which is associated with thermal injuries without compromising wound repair.",{"EN":544},"The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring",{"VOID":546},"10.1186\u002Fs41038-016-0040-1","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002Fdoi\u002F10.1186\u002Fs41038-016-0040-1\u002F5671081",[549,564,576],{"id":550,"sortIndex":19,"researcher":18,"roles":551,"affiliations":552,"properties":561},"101e069d-24d5-4a1e-9070-77f54bc3eb1c",[192],[553],{"id":18,"sortIndex":19,"affiliation":554,"properties":18},{"id":555,"createTime":556,"updateTime":556,"relativeEntities":557,"slug":18,"properties":558,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"66f8c825-e9a6-477c-b11d-1f7e53ebf6b5","2024-01-25T23:24:55.046+00:00",[],{"title":559},{"VI":560},"British College of Osteopathic Medicine (BCOM), London, UK",{"title":562},{"VI":563},"M. Mehta",{"id":565,"sortIndex":262,"researcher":18,"roles":566,"affiliations":567,"properties":573},"81a93bff-c7a3-4433-adb6-8194111e3813",[192],[568],{"id":18,"sortIndex":19,"affiliation":569,"properties":18},{"id":555,"createTime":556,"updateTime":556,"relativeEntities":570,"slug":18,"properties":571,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":572},{"VI":560},{"title":574},{"VI":575},"K. J. Rolfe",{"id":577,"sortIndex":222,"researcher":18,"roles":578,"affiliations":579,"properties":590},"6073287f-83b5-4c33-bc40-b7c870cbf486",[192],[580],{"id":18,"sortIndex":19,"affiliation":581,"properties":18},{"id":582,"createTime":583,"updateTime":584,"relativeEntities":585,"slug":586,"properties":587,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"635a96bb-8e58-43b5-aa71-8530d6c3a3af","2023-12-27T09:32:35.794+00:00","2024-12-22T02:14:11.471+00:00",[],"The-Royal-Marsden-Hospital-London-UK",{"title":588},{"VI":589},"The Royal Marsden Hospital, London , UK",{"title":591},{"VI":592},"O. A. Branford",{"url":547,"publisher":594,"properties":621},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":595,"slug":10,"properties":596,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":599,"manageAffiliations":600,"indexDatabases":601,"url":18,"thumbnailPath":18,"statistic":616,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":597,"title":598},{"VOID":13},{"EN":15},[],[],[602,609],{"id":94,"indexDatabase":603,"url":107,"indexYears":108,"academicFieldIds":608,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":604,"label":605,"description":606,"key":104,"publicationTags":607,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":610,"url":18,"indexYears":18,"academicFieldIds":615,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":611,"label":612,"description":613,"key":128,"publicationTags":614,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":617,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":618,"totalCitation":151,"totalCitationByYear":619,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":620,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":622,"pages":623},{"VOID":304},{"VOID":624},"1-12","2016-05-04",{"id":627,"createTime":628,"updateTime":629,"relativeEntities":630,"slug":631,"properties":632,"entityType":183,"verifyStatus":184,"verifyTime":629,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":222,"primaryUrl":641,"fullTextUrl":18,"authors":642,"publicationType":273,"publisherRelationship":718,"citationCount":18,"citationInfo":18,"publishDate":751,"publishYear":752,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"fdca6793-5c7f-4c5f-974c-4d5ddf99eeba","2023-12-12T04:46:12.229+00:00","2025-01-07T23:29:06.565+00:00",[],"A-prospective-study-of-time-to-healing-and-hypertrophic-scarring-in-paediatric-burns-every-day-counts",{"references":633,"abstract":635,"title":637,"doi":639},{"VOID":634},"Bock O, Schmid-Ott G, Malewski P, Mrowietz U. Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res. 2006;297:433–8.\nLawrence JW, Mason ST, Schomer K, Klein MB. Epidemiology and impact of scarring after burn injury: a systematic review of the literature. J Burn Care Res. 2012;33(1):136–46.\nBae SH, Bae YC. Analysis of frequency of use of different scar assessment scales based on the scar condition and treatment method. Arch Plast Surg. 2014;41(2):111–5.\nDeitch EA, Wheelahan TM, Rose MP, Clothier J, Cotter J. Hypertrophic burn scars: analysis of variables. J Trauma. 1983;23(10):895–8.\nCubison TC, Pape SA, Parkhouse N. Evidence for the link between healing time and the development of hypertrophic scars (HTS) in paediatric burns due to scald injury. Burns. 2006;32(8):992–9.\nFitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol. 1988;124(6):869–71.\nNedelec B, Shankowsky HA, Tredget EE. Rating the resolving hypertrophic scar: comparison of the Vancouver Scar Scale and scar volume. J Burn Care Rehabil. 2000;21(3):205–12.\nSullivan T, Smith J, Kermode J, McIver E, Courtemanche DJ. Rating the burn scar. J Burn Care Rehab. 1990;11(3):256–60.\nBombaro KM, Engrav LH, Carrougher GJ, Wiechman SA, Faucher L, Costa BA, et al. What is the prevalence of hypertrophic scarring following burns? Burns. 2003;29(4):299–302.\nMahdavian Delavary B, van der Veer WM, Ferreira JA, Niessen FB. Formation of hypertrophic scars: evolution and susceptibility. J Plast Surg Hand Surg. 2012;46(2):95–101.\nHassan S, Reynolds G, Clarkson J, Brooks P. Challenging the dogma: relationship between time to healing and formation of hypertrophic scars after burn injuries. J Burn Care Res. 2014;35(2):e118–24.\nThompson CM, Hocking AM, Honari S, Muffley LA, Ga M, Gibran NS. Genetic risk factors for hypertrophic scar development. J Burn Care Res. 2013;34(5):477–82.\nGangemi EN, Gregori D, Berchialla P, Zingarelli E, Cairo M, Bollero D, et al. Epidemiology and risk factors for pathologic scarring after burn wounds. Arch Facial Plast Surg. 2008;10(2):93–102.\nTyack Z, Wasiak J, Spinks A, Kimble R, Simons M. A guide to choosing a burn scar rating scale for clinical or research use. Burns. 2013;39(7):1341–50.\nSoltani AM, Francis CS, Motamed A, Karatsonyi AL, Hammoudeh JA, Sanchez-Lara PA, et al. Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups. Clin Epidemiol. 2012;4:187–91.\nBerchialla P, Gangemi EN, Foltran F, Haxhiaj A, Buja A, Lazzarato F, et al. Predicting severity of pathological scarring due to burn injuries: a clinical decision making tool using Bayesian networks. Int Wound J. 2014;11(3):246–52.\nSimpson L. Population forecasts for Birmingham with an ethnic group dimension. CCSR Working Paper 2007-2012. http:\u002F\u002Fhummedia.manchester.ac.uk\u002Finstitutes\u002Fcmist\u002Farchive-publications\u002Fworking-papers\u002F2007\u002F2007-12-population-forecasts-for-birmingham.pdf. Accessed 19 Dec 2016.\nSpurr ED, Shakespeare PG. Incidence of hypertrophic scarring in burn-injured children. Burns. 1990;16:179–81.\nZeitlin R, Järnberg J, Somppi E, Sundell B. The late appearance of scars after burns in childhood. Scand J Plast Reconstr Hand Surg. 1997;31(4):319–25.\nDedovic Z, Koupilova I, Brychta P. Time trends in incidence of hypertrophic scarring in children treated for burns. Acta Chir Plast. 1999;41:87–90.",{"EN":636},"It is commonly accepted that burns taking longer than 3 weeks to heal have a much higher rate of hypertrophic scarring than those which heal more quickly. However, some of our patients develop hypertrophic scars despite healing within this 3-week period. We performed a prospective study of 383 paediatric burns treated non-operatively at a regional burns centre over a 2-year period from May 2011 to April 2013. Scar assessment was performed by a senior burns therapist using the Vancouver Scar Scale. Overall rates of hypertrophic scarring were 17.2%. Time to healing was the strongest predictor of developing hypertrophic scarring, and the earliest hypertrophic scar developed in a patient who was healed after 8 days. The risk of hypertrophic scarring was multiplied by 1.138 for every additional day taken for the burn wound to heal. There was a trend towards higher rates of hypertrophic scarring in non-white skin types but this did not reach statistical significance. The risk of hypertrophic scarring increases with every day and, therefore, every effort should be made to get the wound healed as quickly as possible, even within the traditional 3-week period usually allowed for healing. We believe that the traditional dogma of aiming for healing within 3 weeks is overly simplistic and should be abandoned: in paediatric burns, every day counts. Not applicable.",{"EN":638},"A prospective study of time to healing and hypertrophic scarring in paediatric burns: every day counts",{"VOID":640},"10.1186\u002Fs41038-016-0068-2","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002Fdoi\u002F10.1186\u002Fs41038-016-0068-2\u002F5680328",[643,658,670,682,694,706],{"id":644,"sortIndex":222,"researcher":18,"roles":645,"affiliations":646,"properties":655},"731e2f4d-f99d-4508-b5f3-23e8fa9b6089",[192],[647],{"id":18,"sortIndex":19,"affiliation":648,"properties":18},{"id":649,"createTime":650,"updateTime":650,"relativeEntities":651,"slug":18,"properties":652,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"21812ec0-031c-45b1-b761-1eb1791ceea7","2023-12-12T04:46:12.257+00:00",[],{"title":653},{"VI":654},"Burns Centre, Birmingham Children’s Hospital, Birmingham, UK",{"title":656},{"VI":657},"Lisa Charles",{"id":659,"sortIndex":190,"researcher":18,"roles":660,"affiliations":661,"properties":667},"a8e30e44-9a06-48cb-a74d-d49751cefe88",[192],[662],{"id":18,"sortIndex":19,"affiliation":663,"properties":18},{"id":649,"createTime":650,"updateTime":650,"relativeEntities":664,"slug":18,"properties":665,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":666},{"VI":654},{"title":668},{"VI":669},"Yvonne Wilson",{"id":671,"sortIndex":19,"researcher":18,"roles":672,"affiliations":673,"properties":679},"e409e09e-fdbf-4677-a804-d0de334300ed",[192],[674],{"id":18,"sortIndex":19,"affiliation":675,"properties":18},{"id":649,"createTime":650,"updateTime":650,"relativeEntities":676,"slug":18,"properties":677,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":678},{"VI":654},{"title":680},{"VI":681},"Elizabeth Chipp",{"id":683,"sortIndex":144,"researcher":18,"roles":684,"affiliations":685,"properties":691},"aa4fd6e1-94c6-4d34-84d3-1a3acbf70045",[192],[686],{"id":18,"sortIndex":19,"affiliation":687,"properties":18},{"id":649,"createTime":650,"updateTime":650,"relativeEntities":688,"slug":18,"properties":689,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":690},{"VI":654},{"title":692},{"VI":693},"Kate Whiting",{"id":695,"sortIndex":262,"researcher":18,"roles":696,"affiliations":697,"properties":703},"bef5f326-a03b-487f-90b5-38dc59fddbc7",[192],[698],{"id":18,"sortIndex":19,"affiliation":699,"properties":18},{"id":649,"createTime":650,"updateTime":650,"relativeEntities":700,"slug":18,"properties":701,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":702},{"VI":654},{"title":704},{"VI":705},"Clare Thomas",{"id":707,"sortIndex":80,"researcher":18,"roles":708,"affiliations":709,"properties":715},"b5d4489d-301c-4f23-b866-767fcaeff69b",[192],[710],{"id":18,"sortIndex":19,"affiliation":711,"properties":18},{"id":649,"createTime":650,"updateTime":650,"relativeEntities":712,"slug":18,"properties":713,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":714},{"VI":654},{"title":716},{"VI":717},"Naiem Moiemen",{"url":641,"publisher":719,"properties":746},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":720,"slug":10,"properties":721,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":724,"manageAffiliations":725,"indexDatabases":726,"url":18,"thumbnailPath":18,"statistic":741,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":722,"title":723},{"VOID":13},{"EN":15},[],[],[727,734],{"id":94,"indexDatabase":728,"url":107,"indexYears":108,"academicFieldIds":733,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":729,"label":730,"description":731,"key":104,"publicationTags":732,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":735,"url":18,"indexYears":18,"academicFieldIds":740,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":736,"label":737,"description":738,"key":128,"publicationTags":739,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":742,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":743,"totalCitation":151,"totalCitationByYear":744,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":745,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":747,"pages":749},{"VOID":748},"5",{"VOID":750},"1-6","2017-01-19",2017,{"id":754,"createTime":755,"updateTime":756,"relativeEntities":757,"slug":758,"properties":759,"entityType":183,"verifyStatus":184,"verifyTime":770,"verifyNote":185,"syncStatus":17,"languages":771,"translateLanguages":773,"viewCount":19,"primaryUrl":775,"fullTextUrl":18,"authors":776,"publicationType":273,"publisherRelationship":858,"citationCount":18,"citationInfo":18,"publishDate":886,"publishYear":308,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":887,"isForceReanalyzing":309},"bd471006-07df-4a6d-92da-511d09f5b0f0","2024-04-11T04:24:48.373+00:00","2025-01-08T23:27:13.889+00:00",[],"A-systematic-review-of-objective-burn-scar-measurements",{"keywords":760,"abstract":762,"title":765,"doi":768},{"VI":761,"EN":761},"",{"VI":763,"EN":764},"Sẹo bỏng có vấn đề vẫn là một khía cạnh khó khăn trong điều trị và có thể ảnh hưởng đáng kể đến chất lượng cuộc sống của những người sống sót sau bỏng. Hiện nay, có rất ít phương pháp điều trị có sẵn trong lâm sàng để kiểm soát sẹo không mong muốn, nhưng các chiến lược chống sẹo dược lý thử nghiệm đang bắt đầu xuất hiện. Sự thành công tương đối của chúng phải được dựa trên các phép đo khách quan của sẹo, tuy nhiên hiện tại, đánh giá lâm sàng về sẹo không được thực hiện một cách hệ thống và chủ yếu dựa trên đánh giá chủ quan của bệnh nhân. Tuy nhiên, một số kỹ thuật và thiết bị đang được giới thiệu cho phép phân tích khách quan sẹo bỏng. Mục tiêu của bài viết này là đánh giá các công cụ đo lường khách quan khác nhau hiện có và đề xuất một bộ thiết bị hữu ích phù hợp cho các thử nghiệm lâm sàng về liệu pháp chống sẹo. Một tìm kiếm tài liệu có hệ thống đã được thực hiện bằng cách sử dụng các cơ sở dữ liệu Web of Science, PubMed và Cochrane. Các thiết bị được xác định sau đó được phân loại và nhóm theo các thông số mà chúng đo lường. Các công cụ này sau đó được so sánh và đánh giá dựa trên tính tái lập của các đánh giá giữa các người đánh giá và trong cùng một người đánh giá, sự dễ sử dụng và chi phí. Sau khi loại bỏ các bản sao, 5062 bài báo đã được thu thập trong tìm kiếm. Sau khi sàng lọc thêm, 157 bài báo sử dụng các hệ thống hoặc công cụ đo lường sẹo bỏng khách quan đã được thu thập. Các thiết bị đo lường sẹo có thể được phân loại rộng rãi thành các thiết bị đo màu sắc, biến số đo lường, kết cấu, các đặc tính sinh cơ học và rối loạn sinh lý bệnh. Các công cụ đo lường sẹo khách quan cho phép đánh giá chính xác và có thể tái lập quá trình đánh giá sẹo, điều này rất quan trọng cho cả sử dụng lâm sàng và khoa học. Tuy nhiên, các nghiên cứu để đánh giá hiệu suất tương đối và những ưu điểm của các công cụ này vẫn khan hiếm, và vẫn còn các yếu tố như ngứa và đau, mà không thể đo lường một cách khách quan. Sau khi xem xét các bằng chứng có sẵn, một bộ thiết bị đo lường sẹo khách quan được đề xuất bao gồm camera 3D (Eykona\u002FLifeviz\u002FVectra H1) cho diện tích bề mặt và thể tích, colorimeter DSM II cho màu sắc, siêu âm tần số cao Dermascan cho độ dày sẹo và Cutometer cho độ đàn hồi và tính linh hoạt của da.","Problematic scarring remains a challenging aspect to address in the treatment of burns and can significantly affect the quality of life of the burn survivor. At present, there are few treatments available in the clinic to control adverse scarring, but experimental pharmacological anti-scarring strategies are now beginning to emerge. Their comparative success must be based on objective measurements of scarring, yet currently the clinical assessment of scars is not carried out systematically and is mostly based on subjective review of patients. However, several techniques and devices are being introduced that allow objective analysis of the burn scar. The aim of this article is to evaluate various objective measurement tools currently available and recommend a useful panel that is suitable for use in clinical trials of anti-scarring therapies. A systematic literature search was done using the Web of Science, PubMed and Cochrane databases. The identified devices were then classified and grouped according to the parameters they measured. The tools were then compared and assessed in terms of inter- and intra-rater reproducibility, ease of use and cost. After duplicates were removed, 5062 articles were obtained in the search. After further screening, 157 articles which utilised objective burn scar measurement systems or tools were obtained. The scar measurement devices can be broadly classified into those measuring colour, metric variables, texture, biomechanical properties and pathophysiological disturbances. Objective scar measurement tools allow the accurate and reproducible evaluation of scars, which is important for both clinical and scientific use. However, studies to evaluate their relative performance and merits of these tools are scarce, and there remain factors, such as itch and pain, which cannot be measured objectively. On reviewing the available evidence, a panel of devices for objective scar measurement is recommended consisting of the 3D cameras (Eykona\u002FLifeviz\u002FVectra H1) for surface area and volume, DSM II colorimeter for colour, Dermascan high-frequency ultrasound for scar thickness and Cutometer for skin elasticity and pliability.",{"VI":766,"EN":767},"Đánh giá có hệ thống các phương pháp đo lường khách quan sẹo bỏng","A systematic review of objective burn scar measurements",{"VOID":769},"10.1186\u002Fs41038-016-0036-x","2024-12-31T10:51:05.486+00:00",[772],"EN",[774],"VI","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002Fdoi\u002F10.1186\u002Fs41038-016-0036-x\u002F5671059",[777,805,817,832,847],{"id":778,"sortIndex":19,"researcher":18,"roles":779,"affiliations":780,"properties":800},"7039769f-ffdb-4c87-af58-7590cfb8d181",[],[781,790],{"id":18,"sortIndex":19,"affiliation":782,"properties":18},{"id":783,"createTime":784,"updateTime":784,"relativeEntities":785,"slug":786,"properties":787,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"4b462d78-3ca8-4c5c-ba2d-2f11cebf4369","2024-04-11T04:24:48.427+00:00",[],"The-Healing-Foundation-Burn-Research-Centre-University-Hospital-Birmingham-Foundation-Trust-Birmingham-UK",{"title":788},{"EN":789},"The Healing Foundation Burn Research Centre, University Hospital Birmingham Foundation Trust, Birmingham, UK",{"id":18,"sortIndex":19,"affiliation":791,"properties":18},{"id":792,"createTime":793,"updateTime":794,"relativeEntities":795,"slug":796,"properties":797,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"d6631af1-8e7f-46f5-9a09-59369c1721b0","2024-01-13T05:31:31.367+00:00","2024-10-04T21:11:11.277+00:00",[],"School-of-Clinical-and-Experimental-Medicine-College-of-Medical-and-Dental-Sciences-University-of-Birmingham-Birmingham-UK",{"title":798},{"VI":799},"School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK",{"title":801,"email":803},{"EN":802},"Kwang Chear Lee",{"VOID":804},"kwangchear@hotmail.com",{"id":806,"sortIndex":144,"researcher":18,"roles":807,"affiliations":808,"properties":814},"78c26305-98de-476b-8252-e41c5b92c21b",[],[809],{"id":18,"sortIndex":19,"affiliation":810,"properties":18},{"id":792,"createTime":793,"updateTime":794,"relativeEntities":811,"slug":796,"properties":812,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":813},{"VI":799},{"title":815},{"EN":816},"Ann Logan",{"id":818,"sortIndex":262,"researcher":18,"roles":819,"affiliations":820,"properties":829},"dd0ba27b-3e83-4a41-b2ce-c6606a61cec6",[],[821],{"id":18,"sortIndex":19,"affiliation":822,"properties":18},{"id":823,"createTime":824,"updateTime":824,"relativeEntities":825,"slug":18,"properties":826,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"48bca43b-d107-46d9-975d-fcbb0597d1e1","2023-12-27T15:45:51.343+00:00",[],{"title":827},{"VI":828},"School of Chemical Engineering, University of Birmingham, Birmingham, UK",{"title":830},{"EN":831},"Liam Grover",{"id":833,"sortIndex":222,"researcher":18,"roles":834,"affiliations":835,"properties":844},"935d35ba-b92f-44df-ac95-6a7cd205a33b",[],[836],{"id":18,"sortIndex":19,"affiliation":837,"properties":18},{"id":838,"createTime":839,"updateTime":839,"relativeEntities":840,"slug":18,"properties":841,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"69f5783f-0bc3-4b1d-a35f-b369cc003966","2023-12-26T10:56:19.908+00:00",[],{"title":842},{"VI":843},"Public Health, Epidemiology and Biostatistics, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK",{"title":845},{"EN":846},"Janine Dretzke",{"id":848,"sortIndex":80,"researcher":18,"roles":849,"affiliations":850,"properties":856},"219fd46c-91cf-4fc5-b5af-d506f0024562",[],[851],{"id":18,"sortIndex":19,"affiliation":852,"properties":18},{"id":783,"createTime":784,"updateTime":784,"relativeEntities":853,"slug":786,"properties":854,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":855},{"EN":789},{"title":857},{"EN":717},{"url":18,"publisher":859,"properties":18},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":860,"slug":10,"properties":861,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":864,"manageAffiliations":865,"indexDatabases":866,"url":18,"thumbnailPath":18,"statistic":881,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":862,"title":863},{"VOID":13},{"EN":15},[],[],[867,874],{"id":94,"indexDatabase":868,"url":107,"indexYears":108,"academicFieldIds":873,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":869,"label":870,"description":871,"key":104,"publicationTags":872,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":875,"url":18,"indexYears":18,"academicFieldIds":880,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":876,"label":877,"description":878,"key":128,"publicationTags":879,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":882,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":883,"totalCitation":151,"totalCitationByYear":884,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":885,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},"2016-04-27",[888,890,892,894,896,898,900,902,904,906,908,910,912,914,916,918,920,922,924,926,928,930,932,934,936,938,940,942,944,946,948,950,952,954,956,958,960,962,964,966,968,970,972,974,976,978,980,982,984,986,988,990,992,994,996,998,1000,1002,1004,1006,1008,1010,1012,1014,1016,1018,1020,1022,1024,1026,1028,1030,1032,1034,1036,1038,1040,1042,1044,1046,1048,1050,1052,1054,1056,1058,1060,1062,1064,1066,1068,1070,1072,1074,1076,1078,1080,1082,1084,1086,1088,1090,1092,1094,1096,1098,1100,1102,1104,1106,1108,1110,1112,1114,1116,1118,1120,1122,1124,1126,1128,1130,1132,1134,1136,1138,1140,1142,1144,1146,1148,1150,1152,1154,1156,1158,1160,1162,1164,1166,1168,1170,1172,1174,1176,1178,1180,1182,1184,1186,1188,1190,1192,1194,1196,1198,1200,1202,1204,1206,1208,1210,1212,1214,1216,1218,1220,1222,1224,1226,1228,1230,1232,1234,1236,1238,1240,1242,1244,1246,1248,1250,1252,1254,1256,1258,1260,1262,1264,1266,1268,1270,1272,1274,1276,1278,1280,1282,1284,1286,1288,1290,1292,1294,1296,1298,1300,1302,1304,1306,1308,1310,1312,1314,1316,1318,1320,1322,1324,1326,1328,1330,1332,1334,1336,1338,1340,1342,1344,1346,1348,1350,1352,1354,1356,1358,1360,1362,1364,1366,1368,1370,1372,1374,1376,1378,1380,1382,1384,1386,1388,1390,1392,1394,1396,1398,1400],{"id":18,"text":889,"url":18,"identifiers":18},"World Health Organisation. Disease and injury regional estimates, 2004-2008. [19th Apr 2016] Available from: http:\u002F\u002Fwww.who.int\u002Fhealthinfo\u002Fglobal_burden_disease\u002Festimates_regional_2004_2008\u002Fen\u002F",{"id":18,"text":891,"url":18,"identifiers":18},"Global Health Estimates: deaths, disability-adjusted life year (DALYs), years of life lost (YLL) and years lost due to disability (YLD) by cause, age and sex, 2000–2012. Geneva: World Health Organization. [29 Feb 2016]. Available from: http:\u002F\u002Fwww.who.int\u002Fhealthinfo\u002Fglobal_burden_disease\u002Festimates\u002Fen\u002F.",{"id":18,"text":893,"url":18,"identifiers":18},"Brusselaers N, Hoste EA, Monstrey S, Colpaert KE, De Waele JJ, Vandewoude KH, et al. Outcome and changes over time in survival following severe burns from 1985 to 2004. Intensive Care Med. 2005;31(12):1648–53.",{"id":18,"text":895,"url":18,"identifiers":18},"Draaijers LJ, Tempelman FR, Botman YA, Tuinebreijer WE, Middelkoop E, Kreis RW, et al. The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation. Plast Reconstr Surg. 2004;113(7):1960–5. discussion 6-7.",{"id":18,"text":897,"url":18,"identifiers":18},"Brusselaers N, Pirayesh A, Hoeksema H, Verbelen J, Blot S, Monstrey S. Burn scar assessment: a systematic review of different scar scales. The Journal of surgical research. 2010;164(1):e115–23.",{"id":18,"text":899,"url":18,"identifiers":18},"Gankande TU, Duke JM, Danielsen PL, DeJong HM, Wood FM, Wallace HJ. Reliability of scar assessments performed with an integrated skin testing device - The DermaLab Combo((R)). Burns : journal of the International Society for Burn Injuries. 2014;40(8):1521–9.",{"id":18,"text":901,"url":18,"identifiers":18},"Kaartinen IS, Valisuo PO, Alander JT, Kuokkanen HO. Objective scar assessment--a new method using standardized digital imaging and spectral modelling. Burns : journal of the International Society for Burn Injuries. 2011;37(1):74–81.",{"id":18,"text":903,"url":18,"identifiers":18},"Kaartinen IS, Valisuo PO, Bochko V, Alander JT, Kuokkanen HO. How to assess scar hypertrophy--a comparison of subjective scales and Spectrocutometry: a new objective method. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair. Society. 2011;19(3):316–23.",{"id":18,"text":905,"url":18,"identifiers":18},"Hoogewerf CJ, van Baar ME, Middelkoop E, van Loey NE. Impact of facial burns: Relationship between depressive symptoms, self-esteem and scar severity. Gen Hosp Psychiatry. 2014;36(3):271–6.",{"id":18,"text":907,"url":18,"identifiers":18},"Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159–74.",{"id":18,"text":909,"url":18,"identifiers":18},"Alster TS, Lewis AB, Rosenbach A, et al. Laser scar revision: comparison of CO2 laser vaporization with and without simultaneous pulsed dye laser treatment. Dermatologic surgery : official publication for American Society for Dermatologic Surgery. 1998;24(12):1299–302.",{"id":18,"text":911,"url":18,"identifiers":18},"Winkler AD, Spillmann L, Werner JS, Webster MA. Asymmetries in blue-yellow color perception and in the color of 'the dress'. Current biology: CB. 2015.",{"id":18,"text":913,"url":18,"identifiers":18},"Tseng FY, Chao CJ, Feng WY, Hwang SL. Assessment of human color discrimination based on illuminant color, ambient illumination and screen background color for visual display terminal workers. Ind Health. 2010;48(4):438–46.",{"id":18,"text":915,"url":18,"identifiers":18},"Shuwairi SM, Cronin-Golomb A, McCarley RW, O'Donnell BF. Color discrimination in schizophrenia. Schizophr Res. 2002;55(1-2):197–204.",{"id":18,"text":917,"url":18,"identifiers":18},"Draaijers LJ, Tempelman FR, Botman YA, Kreis RW, Middelkoop E, van Zuijlen PP. Colour evaluation in scars: tristimulus colorimeter, narrow-band simple reflectance meter or subjective evaluation? Burns : journal of the International Society for Burn Injuries. 2004;30(2):103–7.",{"id":18,"text":919,"url":18,"identifiers":18},"Davey RB, Sprod RT, Neild TO. Computerised colour: a technique for the assessment of burn scar hypertrophy. A preliminary report. Burns : journal of the International Society for Burn Injuries. 1999;25(3):207–13.",{"id":18,"text":921,"url":18,"identifiers":18},"Li-Tsang CW, Lau JC, Liu SK. Validation of an objective scar pigmentation measurement by using a spectrocolorimeter. Burns : journal of the International Society for Burn Injuries. 2003;29(8):779–84.",{"id":18,"text":923,"url":18,"identifiers":18},"Chan HH, Wong DS, Ho WS, Lam LK, Wei W, et al. The use of pulsed dye laser for the prevention and treatment of hypertrophic scars in chinese persons. Dermatologic surgery : official publication for American Society for Dermatologic Surgery. 2004;30(7):987–94. discussion 94.",{"id":18,"text":925,"url":18,"identifiers":18},"Kim MS, Rodney WN, Cooper T, Kite C, Reece GP, Markey MK. Towards quantifying the aesthetic outcomes of breast cancer treatment: comparison of clinical photography and colorimetry. J Eval Clin Pract. 2009;15(1):20–31.",{"id":18,"text":927,"url":18,"identifiers":18},"van der Wal M, Bloemen M, Verhaegen P, Tuinebreijer W, de Vet H, van Zuijlen P, et al. Objective color measurements: clinimetric performance of three devices on normal skin and scar tissue. Journal of burn care & research : official publication of the American Burn Association. 2013;34(3):e187–94.",{"id":18,"text":929,"url":18,"identifiers":18},"Akita S, Akino K, Imaizumi T, Hirano A. A basic fibroblast growth factor improved the quality of skin grafting in burn patients. Burns : journal of the International Society for Burn Injuries. 2005;31(7):855–8.",{"id":18,"text":931,"url":18,"identifiers":18},"Ardigò M, Muzio F, Picardo M, Brazzelli V. In: Picardo M, Taïeb A, editors. Non-invasive methods for vitiligo evaluation. London, New York: Springer Heidelberg Dordrecht; 2010.",{"id":18,"text":933,"url":18,"identifiers":18},"Yip C. Re-pigmentation of skin following wounding. Manchester, UK: The University of Manchester; 2013.",{"id":18,"text":935,"url":18,"identifiers":18},"Barel AO, Clarys P, Alewaeters K, Duez C, Hubinon JL, Mommaerts M. The Visi-Chroma VC-100: a new imaging colorimeter for dermatocosmetic research. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2001;7(1):24–31.",{"id":18,"text":937,"url":18,"identifiers":18},"Hallam MJ, McNaught K, Thomas AN, Nduka C. A practical and objective approach to scar colour assessment. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2013;66(10):e271–6.",{"id":18,"text":939,"url":18,"identifiers":18},"van der Wal MB, van Zuijlen PP, van de Ven P, Middelkoop E. Topical silicone gel versus placebo in promoting the maturation of burn scars: a randomized controlled trial. Plast Reconstr Surg. 2010;126(2):524–31.",{"id":18,"text":941,"url":18,"identifiers":18},"Verhaegen PD, Bloemen MC, van der Wal MB, Vloemans AF, Tempelman FR, Beerthuizen GI, et al. Skin stretching for primary closure of acute burn wounds. Burns: journal of the International Society for Burn Injuries. 2014;40(8):1727–37.",{"id":18,"text":943,"url":18,"identifiers":18},"Nedelec B, Correa JA, de Oliveira A, LaSalle L, Perrault I. Longitudinal burn scar quantification. Burns : journal of the International Society for Burn Injuries. 2014;40(8):1504–12.",{"id":18,"text":945,"url":18,"identifiers":18},"Oliveira GV, Chinkes D, Mitchell C, Oliveras G, Hawkins HK, Herndon DN, et al. Objective assessment of burn scar vascularity, erythema, pliability, thickness, and planimetry. Dermatologic surgery : official publication for American Society for Dermatologic Surgery. 2005;31(1):48–58.",{"id":18,"text":947,"url":18,"identifiers":18},"Nedelec B, Correa JA, Rachelska G, Armour A, LaSalle L. Quantitative measurement of hypertrophic scar: intrarater reliability, sensitivity, and specificity. Journal of burn care & research : official publication of the American Burn Association. 2008;29(3):489–500.",{"id":18,"text":949,"url":18,"identifiers":18},"Cheon Y, Lee W, Rah D. Objective analysis of burn scar color by L*a*b* color coordinates. Burns : journal of the International Society for Burn Injuries. 2009;35:S33.",{"id":18,"text":951,"url":18,"identifiers":18},"Cheon YW, Lee WJ, Rah DK. Objective and quantitative evaluation of scar color using the L*a*b* color coordinates. The Journal of craniofacial surgery. 2010;21(3):679–84.",{"id":18,"text":953,"url":18,"identifiers":18},"Valisuo P, Harju T, Alander J. Reflectance measurement using digital camera and a protecting dome with built in light source. J Biophotonics. 2011;4(7-8):559–64.",{"id":18,"text":955,"url":18,"identifiers":18},"Bae EJ, Seo SH, Kye YC, Ahn HH. A quantitative assessment of the human skin surface using polarized light digital photography and its dermatologic significance. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2010;16(3):270–4.",{"id":18,"text":957,"url":18,"identifiers":18},"Khorasani H, Zheng Z, Nguyen C, Zara J, Zhang X, Wang J, et al. A quantitative approach to scar analysis. Am J Pathol. 2011;178(2):621–8.",{"id":18,"text":959,"url":18,"identifiers":18},"Ferreira T, Rasband W. ImageJ User Guide — IJ 1.46 2010—2012 [2nd September 2015]. imagej.nih.gov\u002Fij\u002Fdocs\u002Fguide\u002F].",{"id":18,"text":961,"url":18,"identifiers":18},"Burke-Smith A, Collier J, Jones I. A comparison of non-invasive imaging modalities: Infrared thermography, spectrophotometric intracutaneous analysis and laser Doppler imaging for the assessment of adult burns. Burns : journal of the International Society for Burn Injuries. 2015.",{"id":18,"text":963,"url":18,"identifiers":18},"Jones HG. Clinimetrics of tristimulus colourimeters in scar assessment: a review of evidence. J Wound Care. 2012;21(1):30–5.",{"id":18,"text":965,"url":18,"identifiers":18},"Moncrieff M, Cotton S, Claridge E, Hall P. Spectrophotometric intracutaneous analysis: a new technique for imaging pigmented skin lesions. The British journal of dermatology. 2002;146(3):448–57.",{"id":18,"text":967,"url":18,"identifiers":18},"Ud-Din S, Perry D, Giddings P, Colthurst J, Zaman K, Cotton S, et al. Electrical stimulation increases blood flow and haemoglobin levels in acute cutaneous wounds without affecting wound closure time: Evidenced by non-invasive assessment of temporal biopsy wounds in human volunteers. Exp Dermatol. 2012;21(10):758–64.",{"id":18,"text":969,"url":18,"identifiers":18},"Li ZY, Su HT, Lu SL, Huang LB, Yang XB, Shao TB, et al. [Clinical study on the relationship among the dermis, fat dome and postburn hyperplastic scar formation]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi =. Chinese journal of burns. 2004;20(6):343–6.",{"id":18,"text":971,"url":18,"identifiers":18},"Wan BK, Qi HZ, Ming D, Zhang MJ, Wang QF. Chromatic analysis of burn scar based on ANN by using photoelectrical technology. In: Chance B, Chen M, Chiou AET, Luo Q, editors. Optics in Health Care and Biomedical Optics: Diagnostics and Treatment Ii, Pts 1 and 2. Proceedings of the Society of Photo-Optical Instrumentation Engineers (Spie). 56302005. 538-43.",{"id":18,"text":973,"url":18,"identifiers":18},"Beausang E, Floyd H, Dunn KW, Orton CI, Ferguson MW. A new quantitative scale for clinical scar assessment. Plast Reconstr Surg. 1998;102(6):1954–61.",{"id":18,"text":975,"url":18,"identifiers":18},"Powell MW, Sarkar S, Goldgof DB, Ivanov K. A methodology for extracting objective color from images. IEEE transactions on systems, man, and cybernetics Part B, Cybernetics : a publication of the IEEE Systems, Man, and Cybernetics Society. 2004;34(5):1964–78.",{"id":18,"text":977,"url":18,"identifiers":18},"Anderson JC, Hallam MJ, Nduka C, Osorio D. The challenge of objective scar colour assessment in a clinical setting: using digital photography. J Wound Care. 2015;24(8):379–87.",{"id":18,"text":979,"url":18,"identifiers":18},"van Zuijlen PP, Angeles AP, Kreis RW, Bos KE, Middelkoop E. Scar assessment tools: implications for current research. Plast Reconstr Surg. 2002;109(3):1108–22.",{"id":18,"text":981,"url":18,"identifiers":18},"Valente JH, Jay GD, Schmidt ST, Oh AK, Reinert SE, Zabbo CP. Digital imaging analysis of scar aesthetics. Adv Skin Wound Care. 2012;25(3):119–23.",{"id":18,"text":983,"url":18,"identifiers":18},"Kim DW, Hwang NH, Yoon ES, Dhong ES, Park SH. Outcomes of ablative fractional laser scar treatment. Journal of plastic surgery and hand surgery. 2015;49(2):88–94.",{"id":18,"text":985,"url":18,"identifiers":18},"Bray R, Forrester K, Leonard C, McArthur R, Tulip J, Lindsay R. Laser Doppler imaging of burn scars: a comparison of wavelength and scanning methods. Burns : journal of the International Society for Burn Injuries. 2003;29(3):199–206.",{"id":18,"text":987,"url":18,"identifiers":18},"Ehrlich HP, Kelley SF. Hypertrophic scar: an interruption in the remodeling of repair--a laser Doppler blood flow study. Plast Reconstr Surg. 1992;90(6):993–8.",{"id":18,"text":989,"url":18,"identifiers":18},"Hosoda G, Holloway GA, Heimbach DM. Laser Doppler flowmetry for the early detection of hypertrophic burn scars. The Journal of burn care & rehabilitation. 1986;7(6):496–7.",{"id":18,"text":991,"url":18,"identifiers":18},"Musgrave MA, Umraw N, Fish JS, Gomez M, Cartotto RC. The effect of silicone gel sheets on perfusion of hypertrophic burn scars. The Journal of burn care & rehabilitation. 2002;23(3):208–14.",{"id":18,"text":993,"url":18,"identifiers":18},"Timar-Banu O, Beauregard H, Tousignant J, Lassonde M, Harris P, Viau G, et al. Development of noninvasive and quantitative methodologies for the assessment of chronic ulcers and scars in humans. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair. Society. 2001;9(2):123–32.",{"id":18,"text":995,"url":18,"identifiers":18},"Page RE, Robertson GA, Pettigrew NM. Microcirculation in hypertrophic burn scars. Burns, including thermal injury. 1983;10(1):64–70.",{"id":18,"text":997,"url":18,"identifiers":18},"Leung KS, Sher A, Clark JA, Cheng JC, Leung PC. Microcirculation in hypertrophic scars after burn injury. The Journal of burn care & rehabilitation. 1989;10(5):436–44.",{"id":18,"text":999,"url":18,"identifiers":18},"Clark JA, Leung KS, Cheng JC, Leung PC. The hypertrophic scar and microcirculation properties. Burns : journal of the International Society for Burn Injuries. 1996;22(6):447–50.",{"id":18,"text":1001,"url":18,"identifiers":18},"Forrester KR, Tulip J, Leonard C, Stewart C, Bray RC. A laser speckle imaging technique for measuring tissue perfusion. IEEE transactions on bio-medical engineering. 2004;51(11):2074–84.",{"id":18,"text":1003,"url":18,"identifiers":18},"Wittenberg GP, Fabian BG, Bogomilsky JL, Schultz LR, Rudner EJ, Chaffins ML, et al. Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment. Arch Dermatol. 1999;135(9):1049–55.",{"id":18,"text":1005,"url":18,"identifiers":18},"Allely RR, Van-Buendia LB, Jeng JC, White P, Wu J, Niszczak J, et al. Laser Doppler imaging of cutaneous blood flow through transparent face masks: a necessary preamble to computer-controlled rapid prototyping fabrication with submillimeter precision. Journal of burn care & research : official publication of the American Burn Association. 2008;29(1):42–8.",{"id":18,"text":1007,"url":18,"identifiers":18},"Stewart CJ, Frank R, Forrester KR, Tulip J, Lindsay R, Bray RC. A comparison of two laser-based methods for determination of burn scar perfusion: laser Doppler versus laser speckle imaging. Burns : journal of the International Society for Burn Injuries. 2005;31(6):744–52.",{"id":18,"text":1009,"url":18,"identifiers":18},"moorFLPI-2 (Laser speckle contrast imager) [01\u002F04\u002F2015]. Available from: http:\u002F\u002Fus.moor.co.uk\u002Fproduct\u002Fmoorflpi-2-\u002F291.",{"id":18,"text":1011,"url":18,"identifiers":18},"Prindeze NJ, Hoffman HA, Ardanuy JG, Zhang J, Carney BC, Moffatt LT, et al. Active Dynamic Thermography is a Sensitive Method for Distinguishing Burn Wound Conversion. Journal of burn care & research : official publication of the American Burn Association. 2015.",{"id":18,"text":1013,"url":18,"identifiers":18},"Monstrey S, Hoeksema H, Verbelen J, Pirayesh A, Blondeel P. Assessment of burn depth and burn wound healing potential. Burns : journal of the International Society for Burn Injuries. 2008;34(6):761–9.",{"id":18,"text":1015,"url":18,"identifiers":18},"Hardwicke J, Thomson R, Bamford A, Moiemen N. A pilot evaluation study of high resolution digital thermal imaging in the assessment of burn depth. Burns : journal of the International Society for Burn Injuries. 2013;39(1):76–81.",{"id":18,"text":1017,"url":18,"identifiers":18},"Coster A, Klein Baltink H, Zilvold G. Thermographic assessment of healed burn wounds. Rays. 1985;10(3):85–8.",{"id":18,"text":1019,"url":18,"identifiers":18},"Horta R, Nascimento R, Vilas-Boas J, Sousa F, Orvalho V, Silva A, et al. Thermographic analysis of facially burned patients. Burns : journal of the International Society for Burn Injuries. 2015.",{"id":18,"text":1021,"url":18,"identifiers":18},"Bhedi A, Saxena AK, Gadani R, Patel R. Digital Photography and Transparency-Based Methods for Measuring Wound Surface Area. The Indian Journal of Surgery. 2013;75(2):111–4.",{"id":18,"text":1023,"url":18,"identifiers":18},"Chang AC, Dearman B, Greenwood JE. A Comparison of Wound Area Measurement Techniques: Visitrak Versus Photography. Eplasty. 2011;11:e18.",{"id":18,"text":1025,"url":18,"identifiers":18},"Cui J, Zhang J, Wang J, Xu M, Pei YH, Wang T, et al. Effect of topical application with mitomycin C in the management of benign cicatricial airway stenosis. Chung-Hua Chieh Ho Ho Hu Hsi Tsa Chih Chinese Journal of Tuberculosis & Respiratory Diseases. 2012;35(12):901–6.",{"id":18,"text":1027,"url":18,"identifiers":18},"Sugama J, Matsui Y, Sanada H, Konya C, Okuwa M, Kitagawa A. A study of the efficiency and convenience of an advanced portable Wound Measurement System (VISITRAK). J Clin Nurs. 2007;16(7):1265–9.",{"id":18,"text":1029,"url":18,"identifiers":18},"van Zuijlen PP, Angeles AP, Suijker MH, Kreis RW, Middelkoop E. Reliability and accuracy of techniques for surface area measurements of wounds and scars. The international journal of lower extremity wounds. 2004;3(1):7–11.",{"id":18,"text":1031,"url":18,"identifiers":18},"Berman B, Young VL, McAndrews J, et al. Objective Assessment of the Precision, Accuracy, and Reliability of a Measurement Method for Keloid Scar Volume (PARKS Study). Dermatologic surgery: official publication for American Society for Dermatologic Surgery. 2015.",{"id":18,"text":1033,"url":18,"identifiers":18},"3dMD static systems [2nd September 2015]. Available from: http:\u002F\u002Fwww.3dmd.com\u002F#3dmd-products.",{"id":18,"text":1035,"url":18,"identifiers":18},"Kim JE, Heo YS, Oh TS, Song HJ, Oh CH. The efficacy of cultured autologous fibroblast injection treatment for depressed acne scar and evaluation by stereoimage optical topometer. Journal of Dermatology Conference: 1st Eastern Asia Dermatology Congress, EADC2010 Fukuoka Japan Conference Start. 2010;37:77.",{"id":18,"text":1037,"url":18,"identifiers":18},"Stekelenburg CM, van der Wal MB, Knol DL, de Vet HC, van Zuijlen PP. Three-dimensional digital stereophotogrammetry: a reliable and valid technique for measuring scar surface area. Plast Reconstr Surg. 2013;132(1):204–11.",{"id":18,"text":1039,"url":18,"identifiers":18},"Lumenta DB, Kitzinger HB, Selig H, Kamolz LP. Objective quantification of subjective parameters in scars by use of a portable stereophotographic system. Ann Plast Surg. 2011;67(6):641–5.",{"id":18,"text":1041,"url":18,"identifiers":18},"Tanaka Y, Tsunemi Y, Kawashima M, Tatewaki N, Nishida H. Objective assessment of skin tightening in Asians using a water-filtered near-infrared (1,000-1,800 nm) device with contact-cooling and freezer-stored gel. Clin Cosmet Investig Dermatol. 2013;6:167–76.",{"id":18,"text":1043,"url":18,"identifiers":18},"Canfield Photography solutions [cited 2015 2nd September]. Available from: http:\u002F\u002Fwww.canfieldsci.com\u002Fimaging-systems\u002Fcategories\u002Fphotography-solutions\u002F.",{"id":18,"text":1045,"url":18,"identifiers":18},"Tanaka Y. Long-term three-dimensional volumetric assessment of skin tightening using a sharply tapered non-insulated microneedle radiofrequency applicator with novel fractionated pulse mode in asians. Lasers Surg Med. 2015;47(8):626–33.",{"id":18,"text":1047,"url":18,"identifiers":18},"Urbanová P, Hejna P, Jurda M. Testing photogrammetry-based techniques for three-dimensional surface documentation in forensic pathology. Forensic Sci Int. 2015;250:77–86.",{"id":18,"text":1049,"url":18,"identifiers":18},"Ardehali B, Nouraei SA, Van Dam H, Dex E, Wood S, Nduka C. Objective assessment of keloid scars with three-dimensional imaging: quantifying response to intralesional steroid therapy. Plastic & Reconstructive Surgery. 2007;119(2):556–61.",{"id":18,"text":1051,"url":18,"identifiers":18},"Hoeffelin H, Jacquemin D, Defaweux V, Nizet JL. A Methodological Evaluation of Volumetric Measurement Techniques including Three-Dimensional Imaging in Breast Surgery. BioMed Research International. 2014;2014:573249.",{"id":18,"text":1053,"url":18,"identifiers":18},"Gee Kee EL, Kimble RM, Stockton KA. 3D photography is a reliable burn wound area assessment tool compared to digital planimetry in very young children. Burns : journal of the International Society for Burn Injuries. 2015.",{"id":18,"text":1055,"url":18,"identifiers":18},"Bowling FL, King L, Fadavi H, Paterson JA, Preece K, Daniel RW, et al. An assessment of the accuracy and usability of a novel optical wound measurement system. Diabetic medicine : a journal of the British Diabetic Association. 2009;26(1):93–6.",{"id":18,"text":1057,"url":18,"identifiers":18},"Bowling FL, King L, Paterson JA, Hu J, Lipsky BA, Matthews DR, et al. Remote assessment of diabetic foot ulcers using a novel wound imaging system. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair. Society. 2011;19(1):25–30.",{"id":18,"text":1059,"url":18,"identifiers":18},"Paterson J. Eykona Medical Imaging FAQ. EYK\u002FAA\u002F021rev02 ed.",{"id":18,"text":1061,"url":18,"identifiers":18},"Lifeviz Mini Technical specifications. Quantificare.",{"id":18,"text":1063,"url":18,"identifiers":18},"Vectra H1 Technical specifications: Canfield Imaging systems Inc. ; [9th December 2015]. Available from: http:\u002F\u002Fwww.canfieldsci.com\u002Fimaging-systems\u002Fvectra-h1-3d-imaging-system\u002F.",{"id":18,"text":1065,"url":18,"identifiers":18},"Raytrix Light field\u002F Plenoptic 3D cameras [cited 2015 2nd September]. Available from: http:\u002F\u002Fwww.raytrix.de\u002Fprodukte\u002F.",{"id":18,"text":1067,"url":18,"identifiers":18},"Straub J, Kerlin S. Development of a Large, Low-Cost, Instant 3D Scanner. Technologies. 2014;2(2):76.",{"id":18,"text":1069,"url":18,"identifiers":18},"Pilley MJ, Hitchens C, Rose G, Alexander S, Wimpenny DI. The use of non-contact structured light scanning in burns pressure splint construction. Burns : journal of the International Society for Burn Injuries. 2011;37(7):1168–73.",{"id":18,"text":1071,"url":18,"identifiers":18},"Kovacs L, Eder M, Hollweck R, Zimmermann A, Settles M, Schneider A, et al. Comparison between breast volume measurement using 3D surface imaging and classical techniques. Breast. 2007;16(2):137–45.",{"id":18,"text":1073,"url":18,"identifiers":18},"Taylor B, McGrouther DA, Bayat A. Use of a non-contact 3D digitiser to measure the volume of keloid scars: a useful tool for scar assessment. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2007;60(1):87–94.",{"id":18,"text":1075,"url":18,"identifiers":18},"Powers PS, Sarkar S, Goldgof DB, Cruse CW, Tsap LV. Scar assessment: current problems and future solutions. Journal of Burn Care & Rehabilitation. 1999;20(1 Pt 1):54–60. discussion 53.",{"id":18,"text":1077,"url":18,"identifiers":18},"Haller HL, Dirnberger J, Giretzlehner M, Rodemund C, Kamolz L. \"Understanding burns\": Research project BurnCase 3D-Overcome the limits of existing methods in burns documentation. Burns : journal of the International Society for Burn Injuries. 2009;35(3):311–7.",{"id":18,"text":1079,"url":18,"identifiers":18},"Thumfart S, Giretzlehner M, Holler J, Ehrenmuller M, Pfurtscheller K, Haller H, et al. Proportionally correct 3D models of infants, children and adolescents for precise burn size measurement. Hannover, Germany: European Burns Association Congress; 2015.",{"id":18,"text":1081,"url":18,"identifiers":18},"Wurzer P, Giretzlehner M, Klein D. SY, Haller H. L., Branski L. K., Benjamin N., et al. Burncase 3D software validation study: Burn size measurement accuracy, test-retest reliability and inter-rater reliability. European Burns Association Congress 2015. Hannover, Germany: Annals of Burns and Fire Disasters-Supplement EBA; 2015.",{"id":18,"text":1083,"url":18,"identifiers":18},"Cheng W, Saing H, Zhou H, Han Y, Peh W, Tam PK. Ultrasound assessment of scald scars in Asian children receiving pressure garment therapy. J Pediatr Surg. 2001;36(3):466–9.",{"id":18,"text":1085,"url":18,"identifiers":18},"Wang ZY, Zhang J, Lu SL. Objective evaluation of burn and post-surgical scars and the accuracy of subjective scar type judgment. Chin Med J. 2008;121(24):2517–20.",{"id":18,"text":1087,"url":18,"identifiers":18},"Sawada Y. A method of recording and objective assessment of hypertrophic burn scars. Burns : journal of the International Society for Burn Injuries. 1994;20(1):76–8.",{"id":18,"text":1089,"url":18,"identifiers":18},"Hambleton J, Shakespeare PG, Pratt BJ. The progress of hypertrophic scars monitored by ultrasound measurements of thickness. Burns : journal of the International Society for Burn Injuries. 1992;18(4):301–7.",{"id":18,"text":1091,"url":18,"identifiers":18},"Li-Tsang CW, Lau JC, Chan CC. Prevalence of hypertrophic scar formation and its characteristics among the Chinese population. Burns : journal of the International Society for Burn Injuries. 2005;31(5):610–6.",{"id":18,"text":1093,"url":18,"identifiers":18},"Lau JC, Li-Tsang CW, Zheng YP. Application of tissue ultrasound palpation system (TUPS) in objective scar evaluation. Burns : journal of the International Society for Burn Injuries. 2005;31(4):445–52.",{"id":18,"text":1095,"url":18,"identifiers":18},"Lai H-yC. Study of pressure effect on hypertrophic scar tissues: The Hong Kong Polytechnic University. 2010.",{"id":18,"text":1097,"url":18,"identifiers":18},"Lau C-mJ. A prospective randomized clinical trial to compare the effectiveness of pressure therapy, silicone gel sheeting and the combined therapy on post-surgical hypertrophic scar: The Hong Kong Polytechnic University. 2006.",{"id":18,"text":1099,"url":18,"identifiers":18},"Nedelec B, Correa JA, Rachelska G, Armour A, LaSalle L. Quantitative measurement of hypertrophic scar: interrater reliability and concurrent validity. Journal of burn care & research : official publication of the American Burn Association. 2008;29(3):501–11.",{"id":18,"text":1101,"url":18,"identifiers":18},"Van den Kerckhove E, Colla C, Van Brussel M. Pressure Therapy: Does it work? Düsseldorf: German Medical Science GMS Publishing House; 2010.",{"id":18,"text":1103,"url":18,"identifiers":18},"Qui L, Jin X, Kingston PA, Luo X, Ding X. Experimental study on BMSCs transfected by endogene inhibiting hypertrophic scar. Chung-Kuo Hsiu Fu Chung Chien Wai Ko Tsa Chih\u002FChinese Journal of Reparative & Reconstructive Surgery. 2008;22(2):212–6.",{"id":18,"text":1105,"url":18,"identifiers":18},"Du YC, Lin CM, Chen YF, Chen CL, Chen T. Implementation of a burn scar assessment system by ultrasound techniques. Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2006;1:2328–31.",{"id":18,"text":1107,"url":18,"identifiers":18},"Danin A, Georgesco G, Le Touze A, Penaud A, Quignon R, Zakine G. Assessment of burned hands reconstructed with Integra by ultrasonography and elastometry. Burns : journal of the International Society for Burn Injuries. 2012;38(7):998–1004.",{"id":18,"text":1109,"url":18,"identifiers":18},"Lacarrubba F, Verzi AE, Tedeschi A, Catalfo P, Nasca MR, Micali G. Clinical and ultrasonographic correlation of acne scars. Dermatol Surg. 2013;39(11):1683–8.",{"id":18,"text":1111,"url":18,"identifiers":18},"Li JQ, Li-Tsang CW, Huang YP, Chen Y, Zheng YP. Detection of changes of scar thickness under mechanical loading using ultrasonic measurement. Burns : journal of the International Society for Burn Injuries. 2013;39(1):89–97.",{"id":18,"text":1113,"url":18,"identifiers":18},"Zhuang A, Nguyen TA, Naheedy J, Krakowski A. Use of intraoperative high-definition ultrasound to accurately gauge scar thickness and identify intra-scar anatomy during multimodal revision of a hypertrophic burn scar. Lasers Surg Med. 2015;47:54–5.",{"id":18,"text":1115,"url":18,"identifiers":18},"Katz SM, Frank DH, Leopold GR, Wachtel TL. Objective measurement of hypertrophic burn scar: a preliminary study of tonometry and ultrasonography. Ann Plast Surg. 1985;14(2):121–7.",{"id":18,"text":1117,"url":18,"identifiers":18},"Zmudzinska M, Czarnecka-Operacz M, Silny W. Principles of dermatologic ultrasound diagnostics. Acta Dermatovenerol Croat. 2008;16(3):126–9.",{"id":18,"text":1119,"url":18,"identifiers":18},"Wohlrab J, Wohlrab D, Finke R, Fischer M, Marsch WC. Ultrasonographic characterization of burn scars in children. Unfallchirurg. 2000;103(9):754–60.",{"id":18,"text":1121,"url":18,"identifiers":18},"Van den Kerckhove E, Staes F, Flour M, Stappaerts K, Boeckx W. Reproducibility of repeated measurements on post-burn scars with Dermascan C. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2003;9(1):81–4.",{"id":18,"text":1123,"url":18,"identifiers":18},"Nedelec B, Shankowsky HA, Tredget EE. Rating the resolving hypertrophic scar: Comparison of the Vancouver Scar Scale and scar volume. J Burn Care Rehabil. 2000;21(3):205–12.",{"id":18,"text":1125,"url":18,"identifiers":18},"Qui L, Jin X, Kingston PA, Luo X, Ding X. [Experimental study on BMSCs transfected by endogene inhibiting hypertrophic scar]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. 2008;22(2):212–6.",{"id":18,"text":1127,"url":18,"identifiers":18},"Cilip CM, Allaf ME, Fried NM. Application of optical coherence tomography and high-frequency ultrasound imaging during noninvasive laser vasectomy. J Biomed Opt. 2012;17(4):046006.",{"id":18,"text":1129,"url":18,"identifiers":18},"Episcan [cited 2015 January]. Available from: http:\u002F\u002Fwww.longportinc.com\u002Fabout\u002Fepiscan.html.",{"id":18,"text":1131,"url":18,"identifiers":18},"Skin scanner DUB [cited 2015 January]. Available from: http:\u002F\u002Fwww.eotech-sa.com\u002FLife-science\u002FSystems\u002FDUBSkin-Scanner\u002FProducts\u002Ft1\u002Fr9\u002Fi107.",{"id":18,"text":1133,"url":18,"identifiers":18},"Verhaegen PD, van der Wal MB, Middelkoop E, van Zuijlen PP. Objective scar assessment tools: a clinimetric appraisal. Plast Reconstr Surg. 2011;127(4):1561–70.",{"id":18,"text":1135,"url":18,"identifiers":18},"Kautzky F, Dahm MW, Drosner M, Köhler LD, Vogt H-J, Borelli S. Direct profilometry of the skin: its reproducibility and variability. J Eur Acad Dermatol Venereol. 1995;5(1):15–23.",{"id":18,"text":1137,"url":18,"identifiers":18},"Lagarde JM, Rouvrais C, Black D, Diridollou S, Gall Y. Skin topography measurement by interference fringe projection: a technical validation. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2001;7(2):112–21.",{"id":18,"text":1139,"url":18,"identifiers":18},"Nardin P, Nita D, Mignot J. Automation of a series of cutaneous topography measurements from silicon rubber replicas. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2002;8(2):112–7.",{"id":18,"text":1141,"url":18,"identifiers":18},"Fischer TW, Wigger-Alberti W, Elsner P. Direct and non-direct measurement techniques for analysis of skin surface topography. Skin Pharmacol Appl Ski Physiol. 1999;12(1-2):1–11.",{"id":18,"text":1143,"url":18,"identifiers":18},"De Paepe K, Lagarde JM, Gall Y, Roseeuw D, Rogiers V. Microrelief of the skin using a light transmission method. Arch Dermatol Res. 2000;292(10):500–10.",{"id":18,"text":1145,"url":18,"identifiers":18},"Bloemen MC, van Gerven MS, van der Wal MB, Verhaegen PD, Middelkoop E. An objective device for measuring surface roughness of skin and scars. J Am Acad Dermatol. 2011;64(4):706–15.",{"id":18,"text":1147,"url":18,"identifiers":18},"Barolet D, Boucher A. Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series. Lasers Surg Med. 2010;42(6):597–601.",{"id":18,"text":1149,"url":18,"identifiers":18},"Kottner J, Schario M, Garcia Bartels N, Pantchechnikova E, Hillmann K, Blume-Peytavi U. Comparison of two in vivo measurements for skin surface topography. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2013;19(2):84–90.",{"id":18,"text":1151,"url":18,"identifiers":18},"Zhao L, Hung LK, Zhang YT. Electrical properties of normal and scarred skin. In: Chang HK, Zhang YT, editors. Proceedings of the 20th Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Vol 20, Pts 1-6: Biomedical Engineering Towards the Year 2000 and Beyond. Proceedings of Annual International Conference of the Ieee Engineering in Medicine and Biology Society. 201998. p. 2917-20.",{"id":18,"text":1153,"url":18,"identifiers":18},"Moloney EC, Brunner M, Alexander AJ, Clark J. Quantifying fibrosis in head and neck cancer treatment: An overview. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 2015;37(8):1225–31.",{"id":18,"text":1155,"url":18,"identifiers":18},"Dematte MF, Gemperli R, Salles AG, Dolhnikoff M, Lancas T, Nascimento Saldiva PH, et al. Mechanical evaluation of the resistance and elastance of post-burn scars after topical treatment with tretinoin. Clinics. 2011;66(11):1949–54.",{"id":18,"text":1157,"url":18,"identifiers":18},"Clark JA, Cheng JC, Leung KS. Mechanical properties of normal skin and hypertrophic scars. Burns : journal of the International Society for Burn Injuries. 1996;22(6):443–6.",{"id":18,"text":1159,"url":18,"identifiers":18},"Gunner CW, Hutton WC, Burlin TE. The mechanical properties of skin in vivo--a portable hand-held extensometer. The British journal of dermatology. 1979;100(2):161–3.",{"id":18,"text":1161,"url":18,"identifiers":18},"Lim KH, Chew CM, Chen PC, Jeyapalina S, Ho HN, Rappel JK, et al. New extensometer to measure in vivo uniaxial mechanical properties of human skin. J Biomech. 2008;41(5):931–6.",{"id":18,"text":1163,"url":18,"identifiers":18},"Thacker JG. lachetta FA, Allaire PE. In vivo extensometer for measurement of the biomechanical properties of human skin. The Review of scientific instruments. 1977;48(2):181–5.",{"id":18,"text":1165,"url":18,"identifiers":18},"Clark JA, Cheng JC, Leung KS, Leung PC. Mechanical characterisation of human postburn hypertrophic skin during pressure therapy. J Biomech. 1987;20(4):397–406.",{"id":18,"text":1167,"url":18,"identifiers":18},"Chu BM, Brody G. Nondestructive measurements of the properties of healing burn scars. Medical instrumentation. 1975;9(3):139–42.",{"id":18,"text":1169,"url":18,"identifiers":18},"Bartell TH, Monafo WW, Mustoe TA. A new instrument for serial measurements of elasticity in hypertrophic scar. J Burn Care Rehabil. 1988;9(6):657–60.",{"id":18,"text":1171,"url":18,"identifiers":18},"Rennekampff HO, Rabbels J, Reinhard V, Becker ST, Schaller HE. Comparing the Vancouver Scar Scale with the cutometer in the assessment of donor site wounds treated with various dressings in a randomized trial. Journal of burn care & research : official publication of the American Burn Association. 2006;27(3):345–51.",{"id":18,"text":1173,"url":18,"identifiers":18},"Klosova H, Stetinsky J, Bryjova I, Hledik S, Klein L. Objective evaluation of the effect of autologous platelet concentrate on post-operative scarring in deep burns. Burns : journal of the International Society for Burn Injuries. 2013;39(6):1263–76.",{"id":18,"text":1175,"url":18,"identifiers":18},"Nguyen DQ, Potokar TS, Price P. An objective long-term evaluation of Integra (a dermal skin substitute) and split thickness skin grafts, in acute burns and reconstructive surgery. Burns : journal of the International Society for Burn Injuries. 2010;36(1):23–8.",{"id":18,"text":1177,"url":18,"identifiers":18},"Rahmanian-Schwarz A, Beiderwieden A, Willkomm LM, Amr A, Schaller HE, Lotter O. A clinical evaluation of Biobrane((R)) and Suprathel((R)) in acute burns and reconstructive surgery. Burns : journal of the International Society for Burn Injuries. 2011;37(8):1343–8.",{"id":18,"text":1179,"url":18,"identifiers":18},"Fong SS, Hung LK, Cheng JC. The cutometer and ultrasonography in the assessment of postburn hypertrophic scar--a preliminary study. Burns : journal of the International Society for Burn Injuries. 1997;23 Suppl 1:S12–8.",{"id":18,"text":1181,"url":18,"identifiers":18},"Draaijers LJ, Botman YA, Tempelman FR, Kreis RW, Middelkoop E, van Zuijlen PP. Skin elasticity meter or subjective evaluation in scars: a reliability assessment. Burns : journal of the International Society for Burn Injuries. 2004;30(2):109–14.",{"id":18,"text":1183,"url":18,"identifiers":18},"Selig HF, Keck M, Lumenta DB, Mittlbock M, Kamolz LP. The use of a polylactide-based copolymer as a temporary skin substitute in deep dermal burns: 1-year follow-up results of a prospective clinical noninferiority trial. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2013;21(3):402–9.",{"id":18,"text":1185,"url":18,"identifiers":18},"Sin P, Stupka I, Brychta P. Evaluation and comparison of composite and split-thickness skin grafts using cutometer mpa 580. Annals of burns and fire disasters. 2010;23(4):208–13.",{"id":18,"text":1187,"url":18,"identifiers":18},"van Zuijlen PP, Vloemans JF, van Trier AJ, Suijker MH, van Unen E, Groenevelt F, et al. Dermal substitution in acute burns and reconstructive surgery: a subjective and objective long-term follow-up. Plast Reconstr Surg. 2001;108(7):1938–46.",{"id":18,"text":1189,"url":18,"identifiers":18},"Fournier R, Pierard GE. Skin tensile strength modulation by compressive garments in burn patients. A pilot study. Journal of medical engineering & technology. 2000;24(6):277–80.",{"id":18,"text":1191,"url":18,"identifiers":18},"Krusche T, Worret WI. Mechanical properties of keloids in vivo during treatment with intralesional triamcinolone acetonide. Arch Dermatol Res. 1995;287(3-4):289–93.",{"id":18,"text":1193,"url":18,"identifiers":18},"Matsuzaki K, Kumagai N, Fukushi S, Ohshima H, Tanabe M, Ishida H. Cultured epithelial autografting on meshed skin graft scars: evaluation of skin elasticity. The Journal of burn care & rehabilitation. 1995;16(5):496–502.",{"id":18,"text":1195,"url":18,"identifiers":18},"Nguyen NT, Roberge D, Freeman CR, Wong C, Hines J, Turcotte RE. Skin Elasticity as a Measure of Radiation Fibrosis: Is it Reproducible and Does it Correlate with Patient and Physician-reported Measures? Technology in cancer research & treatment. 2013.",{"id":18,"text":1197,"url":18,"identifiers":18},"Rennekampff HO, Rabbels J, Pfau M. Schaller HE. Kongressband \u002F Deutsche Gesellschaft fur Chirurgie Deutsche Gesellschaft fur Chirurgie Kongress. 2002;119:749–55. Evaluating scar development with objective computer-assisted viscoelastic measurement.",{"id":18,"text":1199,"url":18,"identifiers":18},"Anthonissen M, Daly D, Fieuws S, Massage P, Van Brussel M, Vranckx J, et al. Measurement of elasticity and transepidermal water loss rate of burn scars with the Dermalab((R)). Burns : journal of the International Society for Burn Injuries. 2013;39(3):420–8.",{"id":18,"text":1201,"url":18,"identifiers":18},"Spann K, Mileski WJ, Atiles L, Purdue G, Hunt J. The 1996 Clinical Research award. Use of a pneumatonometer in burn scar assessment. The Journal of burn care & rehabilitation. 1996;17(6 Pt 1):515–7.",{"id":18,"text":1203,"url":18,"identifiers":18},"Lye I, Edgar DW, Wood FM, Carroll S. Tissue tonometry is a simple, objective measure for pliability of burn scar: is it reliable? Journal of burn care & research : official publication of the American Burn Association. 2006;27(1):82–5.",{"id":18,"text":1205,"url":18,"identifiers":18},"Akita S, Akino K, Yakabe A, Imaizumi T, Tanaka K, Anraku K, et al. Combined surgical excision and radiation therapy for keloid treatment. The Journal of craniofacial surgery. 2007;18(5):1164–9.",{"id":18,"text":1207,"url":18,"identifiers":18},"Merkel PA, Silliman NP, Denton CP, Furst DE, Khanna D, Emery P, et al. Validity, reliability, and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial. Arthritis Rheum. 2008;59(5):699–705.",{"id":18,"text":1209,"url":18,"identifiers":18},"Magliaro A, Romanelli M. Skin hardness measurement in hypertrophic scars. Wounds-a Compendium of Clinical Research and Practice. 2003;15(3):66–70.",{"id":18,"text":1211,"url":18,"identifiers":18},"Esposito G, Ziccardi P, Scioli M, Pappone N, Scuderi N. The use of a modified tonometer in burn scar therapy. The Journal of burn care & rehabilitation. 1990;11(1):86–90.",{"id":18,"text":1213,"url":18,"identifiers":18},"Wernicke AG, Greenwood EA, Coplowitz S, Parashar B, Kulidzhanov F, Christos PJ, et al. Tissue compliance meter is a more reproducible method of measuring radiation-induced fibrosis than late effects of normal tissue-subjective objective management analytical in patients treated with intracavitary brachytherapy accelerated partial breast irradiation: results of a prospective trial. Breast J. 2013;19(3):250–8.",{"id":18,"text":1215,"url":18,"identifiers":18},"Corica GF, Wigger NC, Edgar DW, Wood FM, Carroll S. Objective measurement of scarring by multiple assessors: is the tissue tonometer a reliable option? Journal of burn care & research : official publication of the American Burn Association. 2006;27(4):520–3.",{"id":18,"text":1217,"url":18,"identifiers":18},"Boyce ST, Supp AP, Wickett RR, Hoath SB, Warden GD. Assessment with the dermal torque meter of skin pliability after treatment of burns with cultured skin substitutes. The Journal of burn care & rehabilitation. 2000;21(1 Pt 1):55–63.",{"id":18,"text":1219,"url":18,"identifiers":18},"McHugh AA, Fowlkes BJ, Maevsky EI, Smith Jr DJ, Rodriguez JL, Garner WL. Biomechanical alterations in normal skin and hypertrophic scar after thermal injury. The Journal of burn care & rehabilitation. 1997;18(2):104–8.",{"id":18,"text":1221,"url":18,"identifiers":18},"Popovic G, Sarvazyan A, Ponomarjev V, Vucelic D. Method and device for noninvasive acoustic testing of elasticity of soft biological tissues. Google Patents. 1992.",{"id":18,"text":1223,"url":18,"identifiers":18},"Verhaegen PD, Res EM, van Engelen A, Middelkoop E, van Zuijlen PP. A reliable, non-invasive measurement tool for anisotropy in normal skin and scar tissue. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2010;16(3):325–31.",{"id":18,"text":1225,"url":18,"identifiers":18},"Ferriero G, Vercelli S, Salgovic L, Stissi V, Sartorio F. Validation of a new device to measure postsurgical scar adherence. Phys Ther. 2010;90(5):776–83.",{"id":18,"text":1227,"url":18,"identifiers":18},"Tsap LV, Goldgof DB, Sarkar S, Powers PS. A vision-based technique for objective assessment of burn scars. IEEE Trans Med Imaging. 1998;17(4):620–33.",{"id":18,"text":1229,"url":18,"identifiers":18},"Zhang Y, Goldgof DB, Sarkar S, Tsap LV. A modeling approach for burn scar assessment using natural features and elastic property. IEEE Trans Med Imaging. 2004;23(10):1325–9.",{"id":18,"text":1231,"url":18,"identifiers":18},"Larrabee Jr WF. A finite element model of skin deformation. I. Biomechanics of skin and soft tissue: a review. Laryngoscope. 1986;96(4):399–405.",{"id":18,"text":1233,"url":18,"identifiers":18},"Zhang Y, Goldgof DB, Sarkar S, Tsap LV. Model-based nonrigid motion analysis using natural feature adaptive mesh. In: Sanfeliu A, Villanueva JJ, Vanrell M, Alquezar R, Huang T, Serra J, editors. 15th International Conference on Pattern Recognition, Vol 3, Proceedings: Image, Speech and Signal Processing. International Conference on Pattern Recognition. 2000. p. 831–5.",{"id":18,"text":1235,"url":18,"identifiers":18},"Palmieri TL, Petuskey K, Bagley A, Takashiba S, Greenhalgh DG, Rab GT. Alterations in functional movement after axillary burn scar contracture: a motion analysis study. The Journal of burn care & rehabilitation. 2003;24(2):104–8.",{"id":18,"text":1237,"url":18,"identifiers":18},"Parry I, Walker K, Niszczak J, Palmieri T, Greenhalgh D. Methods and tools used for the measurement of burn scar contracture. Journal of burn care & research : official publication of the American Burn Association. 2010;31(6):888–903.",{"id":18,"text":1239,"url":18,"identifiers":18},"Rab G, Petuskey K, Bagley A. A method for determination of upper extremity kinematics. Gait & posture. 2002;15(2):113–9.",{"id":18,"text":1241,"url":18,"identifiers":18},"van der Helm FC, Pronk GM. Three-dimensional recording and description of motions of the shoulder mechanism. J Biomech Eng. 1995;117(1):27–40.",{"id":18,"text":1243,"url":18,"identifiers":18},"Koller R, Kargul G, Giovanoli P, Meissl G, Frey M. Quantification of functional results after facial burns by the faciometer. Burns : journal of the International Society for Burn Injuries. 2000;26(8):716–23.",{"id":18,"text":1245,"url":18,"identifiers":18},"Berry RB, Tan OT, Cooke ED, Gaylarde PM, Bowcock SA, Lamberty BG, et al. Transcutaneous oxygen tension as an index of maturity in hypertrophic scars treated by compression. Br J Plast Surg. 1985;38(2):163–73.",{"id":18,"text":1247,"url":18,"identifiers":18},"Ichioka S, Ando T, Shibata M, Sekiya N, Nakatsuka T. Oxygen consumption of keloids and hypertrophic scars. Ann Plast Surg. 2008;60(2):194–7.",{"id":18,"text":1249,"url":18,"identifiers":18},"Rodrigues LM, Roberto MA. Characterization strategies for the functional assessment of the cutaneous lesion. Burns : journal of the International Society for Burn Injuries. 2006;32(7):797–801.",{"id":18,"text":1251,"url":18,"identifiers":18},"Fluhr JW, Feingold KR, Elias PM. Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models. Exp Dermatol. 2006;15(7):483–92.",{"id":18,"text":1253,"url":18,"identifiers":18},"Rosado C, Pinto P, Rodrigues LM. Comparative assessment of the performance of two generations of Tewameter: TM210 and TM300. Int J Cosmet Sci. 2005;27(4):237–41.",{"id":18,"text":1255,"url":18,"identifiers":18},"De Paepe K, Houben E, Adam R, Wiesemann F, Rogiers V. Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2005;11(1):61–9.",{"id":18,"text":1257,"url":18,"identifiers":18},"Anthonissen M. Assessment and conservative treatments of burn scars; Evaluatie en conservatieve behandeling van littekens na brandwonden. 2015.",{"id":18,"text":1259,"url":18,"identifiers":18},"Clarys P, Clijsen R, Taeymans J, Barel AO. Hydration measurements of the stratum corneum: comparison between the capacitance method (digital version of the Corneometer CM 825(R)) and the impedance method (Skicon-200EX(R)). Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2012;18(3):316–23.",{"id":18,"text":1261,"url":18,"identifiers":18},"O'Goshi K, Serup J. Skin conductance; validation of Skicon-200EX compared to the original model, Skicon-100. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2007;13(1):13–8.",{"id":18,"text":1263,"url":18,"identifiers":18},"Magnusson M, Papini RP, Rea SM, Reed CC, Wood FM. Cultured autologous keratinocytes in suspension accelerate epithelial maturation in an in vivo wound model as measured by surface electrical capacitance. Plast Reconstr Surg. 2007;119(2):495–9.",{"id":18,"text":1265,"url":18,"identifiers":18},"Anthonissen M, Daly D, Peeters R, Van Brussel M, Fieuws S, Moortgat P, et al. Reliability of Repeated Measurements on Post-Burn Scars with Corneometer CM 825. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2014.",{"id":18,"text":1267,"url":18,"identifiers":18},"Nuutinen J. Skin dielectric constant at high radiofrequency with special emphasis on radiation-induced late skin reaction [Ph.D. thesis]. Kuopio, Finland: Kuopio University Publications C. Natural and Environmental Sciences 55; 1997.",{"id":18,"text":1269,"url":18,"identifiers":18},"Lahtinen T, Nuutinen J, Alanen E, Turunen M, Nuortio L, Usenius T, et al. Quantitative assessment of protein content in irradiated human skin. Int J Radiat Oncol Biol Phys. 1999;43(3):635–8.",{"id":18,"text":1271,"url":18,"identifiers":18},"Suetake T, Sasai S, Zhen YX, Ohi T, Tagami H. Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars. Arch Dermatol. 1996;132(12):1453–8.",{"id":18,"text":1273,"url":18,"identifiers":18},"Ghassemi P, Travis TE, Moffatt LT, Shupp JW, Ramella-Roman JC. A polarized multispectral imaging system for quantitative assessment of hypertrophic scars. Biomedical optics express. 2014;5(10):3337–54.",{"id":18,"text":1275,"url":18,"identifiers":18},"Ghassemi P, Shupp JW, Moffatt LT, Ramella-Roman JC. A Novel Spectral Imaging System for Quantitative Analysis of Hypertrophic Scar. In: Kollias N, Choi B, Zeng H, Kang HW, Knudsen BE, Wong BJF, et al., editors. Photonic Therapeutics and Diagnostics Ix. Proceedings of SPIE. 85652013.",{"id":18,"text":1277,"url":18,"identifiers":18},"Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008;27(1):45–88.",{"id":18,"text":1279,"url":18,"identifiers":18},"Alex A, Povazay B, Hofer B, Popov S, Glittenberg C, Binder S, et al. Multispectral in vivo three-dimensional optical coherence tomography of human skin. J Biomed Opt. 2010;15(2):026025.",{"id":18,"text":1281,"url":18,"identifiers":18},"Welzel J, Lankenau E, Birngruber R, Engelhardt R. Optical coherence tomography of the human skin. J Am Acad Dermatol. 1997;37(6):958–63.",{"id":18,"text":1283,"url":18,"identifiers":18},"Gambichler T, Moussa G, Sand M, Sand D, Altmeyer P, Hoffmann K. Applications of optical coherence tomography in dermatology. J Dermatol Sci. 2005;40(2):85–94.",{"id":18,"text":1285,"url":18,"identifiers":18},"Welzel J. Optical coherence tomography in dermatology: a review. Skin research and technology: official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2001;7(1):1–9.",{"id":18,"text":1287,"url":18,"identifiers":18},"Steiner R, Kunzi-Rapp K, Scharffetter-Kochanek K. Optical Coherence Tomography: Clinical Applications in Dermatology. Medical Laser Application. 2003;18(3):249–59.",{"id":18,"text":1289,"url":18,"identifiers":18},"Liew YM, McLaughlin RA, Gong P, Wood FM, Sampson DD. In vivo assessment of human burn scars through automated quantification of vascularity using optical coherence tomography. J Biomed Opt. 2013;18(6):061213.",{"id":18,"text":1291,"url":18,"identifiers":18},"Gong P, Chin L, Es'haghian S, Liew YM, Wood FM, Sampson DD, et al. Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking. J Biomed Opt. 2014;19(12):126014.",{"id":18,"text":1293,"url":18,"identifiers":18},"Gong P, McLaughlin RA, Liew YM, Munro PR, Wood FM, Sampson DD. Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking. J Biomed Opt. 2014;19(2):21111.",{"id":18,"text":1295,"url":18,"identifiers":18},"Babalola O, Mamalis A, Lev-Tov H, Jagdeo J. Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis. Arch Dermatol Res. 2014;306(1):1–9.",{"id":18,"text":1297,"url":18,"identifiers":18},"Choi WJ, Reif R, Yousefi S, Wang RK. Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask. J Biomed Opt. 2014;19(3):36010.",{"id":18,"text":1299,"url":18,"identifiers":18},"Wang XQ, Mill J, Kravchuk O, Kimble RM. Ultrasound assessed thickness of burn scars in association with laser Doppler imaging determined depth of burns in paediatric patients. Burns : journal of the International Society for Burn Injuries. 2010;36(8):1254–62.",{"id":18,"text":1301,"url":18,"identifiers":18},"Lo WC, Villiger M, Golberg A, Broelsch GF, Khan S, Lian CG, et al. Longitudinal, 3D In Vivo Imaging of Collagen Remodeling in Murine Hypertrophic Scars using Polarization-sensitive Optical Frequency Domain Imaging. The Journal of investigative dermatology. 2015.",{"id":18,"text":1303,"url":18,"identifiers":18},"Eraud J, Gonnelli D, Carmassi M, Bruzzese L, Andrac-Meyer L, Casanova D, et al. Differential diagnosis between keloid and hypertrophic scars: a new approach by full-field optical coherence tomography. Ann Chir Plast Esthet. 2014;59(4):253–60.",{"id":18,"text":1305,"url":18,"identifiers":18},"Moshref SS, Mufti ST. Keloid and hypertrophic scars: comparative histopathological and immunohistochemical study. Med Sci. 2010;17:3–22.",{"id":18,"text":1307,"url":18,"identifiers":18},"Chen G, Chen J, Zhuo S, Xiong S, Zeng H, Jiang X, et al. Nonlinear spectral imaging of human hypertrophic scar based on two-photon excited fluorescence and second-harmonic generation. The British journal of dermatology. 2009;161(1):48–55.",{"id":18,"text":1309,"url":18,"identifiers":18},"Chen J, Zhuo S, Jiang X, Zhu X, Zheng L, Xie S, et al. Multiphoton microscopy study of the morphological and quantity changes of collagen and elastic fiber components in keloid disease. J Biomed Opt. 2011;16(5):051305.",{"id":18,"text":1311,"url":18,"identifiers":18},"Brewer MB, Yeh A, Torkian B, Sun CH, Tromberg BJ, Wong BJ. Multiphoton imaging of excised normal skin and keloid scar: preliminary investigations. In: Bartels KE, Bass LS, DeRiese WTW, Gregory KW, Hirschberg H, Katzir A, et al., editors. Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems Xiv. Proceedings of the Society of Photo-Optical Instrumentation Engineers (Spie). 53122004. p. 204-8.",{"id":18,"text":1313,"url":18,"identifiers":18},"Chen A, Liu PY, McNeilly C, Cuttle L, Kempf M, Kendall M, et al. Collagen deposition assessment in burn scar tissue using second harmonic generation and multi-photon microscopy. J Investig Dermatol. 2010;130:S16–S.",{"id":18,"text":1315,"url":18,"identifiers":18},"Stoller P, Celliers PM, Reiser KM, Rubenchik AM. Imaging collagen orientation using polarization-modulated second harmonic generation. In: Periasamy A, So PTC, editors. Multiphoton Microscopy in the Biomedical Sciences Ii. Proceedings of the Society of Photo-Optical Instrumentation Engineers (Spie). 46202002. p. 157-65.",{"id":18,"text":1317,"url":18,"identifiers":18},"Kelf TA, Gosnell M, Sandnes B, Guller AE, Shekhter AB, Zvyagin AV. Scar tissue classification using nonlinear optical microscopy and discriminant analysis. J Biophotonics. 2012;5(2):159–67.",{"id":18,"text":1319,"url":18,"identifiers":18},"Da Costa V, Wei R, Lim R, Sun CH, Brown JJ, Wong BJ. Nondestructive imaging of live human keloid and facial tissue using multiphoton microscopy. Arch Facial Plast Surg. 2008;10(1):38–43.",{"id":18,"text":1321,"url":18,"identifiers":18},"Zhu XQ, Zhuo SM, Zheng LQ, Lu KC, Jiang XS, Chen JX, et al. Quantified characterization of human cutaneous normal scar using multiphoton microscopy. J Biophotonics. 2010;3(1-2):108–16.",{"id":18,"text":1323,"url":18,"identifiers":18},"de Vries HJ, Enomoto DN, van Marle J, van Zuijlen PP, Mekkes JR, Bos JD. Dermal organization in scleroderma: the fast Fourier transform and the laser scatter method objectify fibrosis in nonlesional as well as lesional skin. Laboratory investigation; a journal of technical methods and pathology. 2000;80(8):1281–9.",{"id":18,"text":1325,"url":18,"identifiers":18},"Konig K, Riemann I. High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution. J Biomed Opt. 2003;8(3):432–9.",{"id":18,"text":1327,"url":18,"identifiers":18},"Chen ACH, McNeilly C, Liu APY, Flaim CJ, Cuttle L, Kendall M, et al. Second harmonic generation and multiphoton microscopic detection of collagen without the need for species specific antibodies. Burns : journal of the International Society for Burn Injuries. 2011;37(6):1001–9.",{"id":18,"text":1329,"url":18,"identifiers":18},"Jiang Y, Tong Y, Xiao T, Lu S. Phase-contrast microtomography with synchrotron radiation technology: a new noninvasive technique to analyze the three-dimensional structure of dermal tissues. Dermatology. 2012;225(1):75–80.",{"id":18,"text":1331,"url":18,"identifiers":18},"Theer P, Hasan MT, Denk W. Two-photon imaging to a depth of 1000 microm in living brains by use of a Ti:Al2O3 regenerative amplifier. Opt Lett. 2003;28(12):1022–4.",{"id":18,"text":1333,"url":18,"identifiers":18},"Tseng SH, Hsu CK, Yu-Yun Lee J, Tzeng SY, Chen WR, Liaw YK. Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study. J Biomed Opt. 2012;17(7):077005.",{"id":18,"text":1335,"url":18,"identifiers":18},"Rajadhyaksha M, Gonzalez S, Zavislan JM, Anderson RR, Webb RH. In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. The Journal of investigative dermatology. 1999;113(3):293–303.",{"id":18,"text":1337,"url":18,"identifiers":18},"Rolfe H, Wurm E, Gilmore S. An investigation of striae distensae using reflectance confocal microscopy. The Australasian journal of dermatology. 2012;53(3):181–5.",{"id":18,"text":1339,"url":18,"identifiers":18},"Nehal KS, Gareau D, Rajadhyaksha M. Skin imaging with reflectance confocal microscopy. Seminars in cutaneous medicine and surgery. 2008;27(1):37–43.",{"id":18,"text":1341,"url":18,"identifiers":18},"Chang SK, Mirabal YN, Atkinson EN, Cox D, Malpica A, Follen M, et al. Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer. J Biomed Opt. 2005;10(2):024031.",{"id":18,"text":1343,"url":18,"identifiers":18},"Gisquet H, Liu H, Blondel WC, Leroux A, Latarche C, Merlin JL, et al. Intradermal tacrolimus prevent scar hypertrophy in a rabbit ear model: a clinical, histological and spectroscopical analysis. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2011;17(2):160–6.",{"id":18,"text":1345,"url":18,"identifiers":18},"Liu HH, Gisquet H, Guillemin F, Blondel W. Bimodal spectroscopy for in vivo characterization of hypertrophic skin tissue: pre-clinical experimentation, spectral data selection and classification. In: Ramanujam N, Popp J, editors. Clinical and Biomedical Spectroscopy and Imaging Ii. Proceedings of SPIE. 80872011.",{"id":18,"text":1347,"url":18,"identifiers":18},"Hsu CK, Tzeng SY, Yang CC, Lee JY, Huang LL, Chen WR, et al. Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy. Biomedical optics express. 2015;6(2):390–404.",{"id":18,"text":1349,"url":18,"identifiers":18},"Bessonart MN, Macedo N, Carmona C. High resolution B-scan ultrasound of hypertrophic scars. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2005;11(3):185–8.",{"id":18,"text":1351,"url":18,"identifiers":18},"Gangemi EN, Carnino R, Stella M. Videocapillaroscopy in postburn scars: in vivo analysis of the microcirculation. Burns : journal of the International Society for Burn Injuries. 2010;36(6):799–805.",{"id":18,"text":1353,"url":18,"identifiers":18},"Campanati A, Savelli A, Sandroni L, Marconi B, Giuliano A, Giuliodori K, et al. Effect of allium cepa-allantoin-pentaglycan gel on skin hypertrophic scars: clinical and video-capillaroscopic results of an open-label, controlled, nonrandomized clinical trial. Dermatologic surgery : official publication for American Society for Dermatologic Surgery. 2010;36(9):1439–44.",{"id":18,"text":1355,"url":18,"identifiers":18},"Pasqui AL, Pastorelli M, Puccetti L, Beerman U, Biagi F, Camarri A, et al. Microvascular assessment in Behcet disease: videocapillaroscopic study. Int J Tissue React. 2003;25(3):105–15.",{"id":18,"text":1357,"url":18,"identifiers":18},"Hern S, Mortimer PS. In vivo quantification of microvessels in clinically uninvolved psoriatic skin and in normal skin. The British journal of dermatology. 2007;156(6):1224–9.",{"id":18,"text":1359,"url":18,"identifiers":18},"Lamah M, Chaudhry H, Mortimer PS, Dormandy JA. Repeatability of intravital capillaroscopic measurement of capillary density. International journal of microcirculation, clinical and experimental \u002F sponsored by the European Society for Microcirculation. 1996;16(1):23–9.",{"id":18,"text":1361,"url":18,"identifiers":18},"Yoo MG, Kim IH. Keloids and hypertrophic scars: characteristic vascular structures visualized by using dermoscopy. Ann. 2014;26(5):603–9.",{"id":18,"text":1363,"url":18,"identifiers":18},"Wei Y, Li-Tsang CW, Luk DC, Tan T, Zhang W, Chiu TW. A validation study of scar vascularity and pigmentation assessment using dermoscopy. Burns : journal of the International Society for Burn Injuries. 2015;41(8):1717–23.",{"id":18,"text":1365,"url":18,"identifiers":18},"Malenfant A, Forget R, Papillon J, Amsel R, Frigon JY, Choiniere M. Prevalence and characteristics of chronic sensory problems in burn patients. Pain. 1996;67(2-3):493–500.",{"id":18,"text":1367,"url":18,"identifiers":18},"Brown JE, Chatterjee N, Younger J, Mackey S. Towards a physiology-based measure of pain: patterns of human brain activity distinguish painful from non-painful thermal stimulation. PLoS One. 2011;6(9):e24124.",{"id":18,"text":1369,"url":18,"identifiers":18},"Meirte J, Moortgat P, Truijen S, Maertens K, Lafaire C, De Cuyper L, et al. Interrater and intrarater reliability of the Semmes Weinstein aesthesiometer to assess touch pressure threshold in burn scars. Burns : journal of the International Society for Burn Injuries. 2015.",{"id":18,"text":1371,"url":18,"identifiers":18},"Tena BB. Evaluación y prevención de la cronificación del dolor postoperatorio tras toracotomía: Universitat de Barcelona. 2014.",{"id":18,"text":1373,"url":18,"identifiers":18},"Tena B, Escobar B, Arguis MJ, Cantero C, Rios J, Gomar C. Reproducibility of Electronic Von Frey and Von Frey monofilaments testing. The Clinical journal of pain. 2012;28(4):318–23.",{"id":18,"text":1375,"url":18,"identifiers":18},"Perry DM, McGrouther DA, Bayat A. Current tools for noninvasive objective assessment of skin scars. Plast Reconstr Surg. 2010;126(3):912–23.",{"id":18,"text":1377,"url":18,"identifiers":18},"Brandt MG, Moore CC, Micomonaco D, Fung K, Franklin JH, Yoo J, et al. A Prospective randomized evaluation of scar assessment measures. Laryngoscope. 2009;119(5):841–5.",{"id":18,"text":1379,"url":18,"identifiers":18},"Niyaz A, Matsumura H, Watanabe K, Hamamoto T, Matsusawa T. Quantification of the physical properties of keloid and hypertrophic scars using the Vesmeter novel sensing device. Int Wound J. 2012;9(6):643–9.",{"id":18,"text":1381,"url":18,"identifiers":18},"Gankande U, Duke J, Wood F, Danielsen PL, Wallace HEVIDENCE-BASEDRECOMMENDATIONSFORBURNSCARASSESSMENT. Wound Repair Regen. 2015;23(4):A8–9.",{"id":18,"text":1383,"url":18,"identifiers":18},"Gankande TU, Duke JM, Wood FM, Wallace HJ. Interpretation of the DermaLab Combo((R)) pigmentation and vascularity measurements in burn scar assessment: An exploratory analysis. Burns : journal of the International Society for Burn Injuries. 2015;41(6):1176–85.",{"id":18,"text":1385,"url":18,"identifiers":18},"Singer AJ, Thode Jr HC, McClain SA. Development of a histomorphologic scale to quantify cutaneous scars after burns. Acad Emerg Med. 2000;7(10):1083–8.",{"id":18,"text":1387,"url":18,"identifiers":18},"de Rigal J, Abella ML, Giron F, Caisey L, Lefebvre MA. Development and validation of a new Skin Color Chart. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2007;13(1):101–9.",{"id":18,"text":1389,"url":18,"identifiers":18},"Bloemen MC, van Leeuwen MC, van Vucht NE, van Zuijlen PP, Middelkoop E. Dermal substitution in acute burns and reconstructive surgery: a 12-year follow-up. Plast Reconstr Surg. 2010;125(5):1450–9.",{"id":18,"text":1391,"url":18,"identifiers":18},"Blome-Eberwein SA, Roarabaugh C, Gogal C, Eid S. Exploration of nonsurgical scar modification options: can the irregular surface of matured mesh graft scars be smoothed with microdermabrasion? Journal of burn care & research : official publication of the American Burn Association. 2012;33(3):e133–40.",{"id":18,"text":1393,"url":18,"identifiers":18},"Atiyeh BS, Gunn SW, Hayek SN. State of the art in burn treatment. World J Surg. 2005;29(2):131–48.",{"id":18,"text":1395,"url":18,"identifiers":18},"Hoeksema H, Van de Sijpe K, Tondu T, Hamdi M, Van Landuyt K, Blondeel P, et al. Accuracy of early burn depth assessment by laser Doppler imaging on different days post burn. Burns : journal of the International Society for Burn Injuries. 2009;35(1):36–45.",{"id":18,"text":1397,"url":18,"identifiers":18},"Miller RH, Sim I. Physicians' use of electronic medical records: barriers and solutions. Health affairs (Project Hope). 2004;23(2):116–26.",{"id":18,"text":1399,"url":18,"identifiers":18},"Tzou CH, Artner NM, Pona I, Hold A, Placheta E, Kropatsch WG, et al. Comparison of three-dimensional surface-imaging systems. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2014;67(4):489–97.",{"id":18,"text":1401,"url":18,"identifiers":18},"Dobrev H. Application of Cutometer area parameters for the study of human skin fatigue. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2005;11(2):120–2.",{"id":1403,"createTime":1404,"updateTime":1405,"relativeEntities":1406,"slug":1407,"properties":1408,"entityType":183,"verifyStatus":184,"verifyTime":1405,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1417,"fullTextUrl":18,"authors":1418,"publicationType":273,"publisherRelationship":1522,"citationCount":18,"citationInfo":18,"publishDate":1554,"publishYear":1555,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"689cfa9d-300f-437f-88c4-1a1dcde9a765","2024-01-25T12:52:38.968+00:00","2024-12-14T23:15:47.612+00:00",[],"Assessment-and-prediction-of-road-accident-injuries-trend-using-time-series-models-in-Kurdistan",{"references":1409,"abstract":1411,"title":1413,"doi":1415},{"VOID":1410},"Hesari A, Esmaeli A. Estimates of deaths from traffic accidents on life expectancy at birth and the financial burden it (2002). Health Inf Manag. 2004;1(2):27–35.\nMarasy MR, Tabar IM. The burden of road traffic injuries in Isfahan, Iran in 2010. J Kerman Univ Med Sci. 2013;20(5):505–19.\nYazdani CJ, Ahmadi BE, Ghadami M. Mapping of mortality rate in suburban accidents, Mazandaran Province, 2007-2010. J Mazandaran Univ Med Sci. 2012;22(97):50–8.\nGhorbani A, Nabavi fard H, Khoshhal M, Hosseini H. Costs imposed on the effects of mortality due to traffic accidents (Sabzevar). Traffic Manag Stud. 2011;20:49–58.\nAyatollahi SH, Hassanzadeh J, Ramezani A. The burden of traffic accidents in South Khorasan Province, Iran in 2005. Iran J Epidemiol. 2009;4(3):51–7. [In Persian]\nHerman J, Ameratunga S, Jackson R. Burden of road traffic injuries and related risk factors in low and middle-income Pacific Island countries and territories: a systematic review of the scientific literature (TRIP 5). BMC Public Health. 2012;12:479.\nMohan VR, Sarkar R, Abraham VJ, Balraj V, Naumova EN. Differential patterns, trends and hotspots of road traffic injuries on different road networks in Vellore district, southern India. Tropical Med Int Health. 2015;20(3):293–303.\nNaghavi M, Shahraz S, Bartels D, Puthenpurakal JA, Motlagh ME. Adverse health outcomes of road traffic injuries in Iran after rapid motorization. Arch Iran med. 2009;12(3):284–94.\nNaghavi MA, Abolhassani F, Pourmalek F, Jafari N, Moradi LM, Eshrati B. The burden of disease and injury in Iran 2003. Iran J Epidemiol. 2008;4(1):1–19. (Persian)\nMoradi A, Kh R. Trend of traffic accidents and fatalities in Iran over 20 years (1993-2013). J Mazandaran Univ Med Sci. 2014;24(118):186–97.\nGhadirzadeh MR, Shojaei A, Khademi A, Khodadoost M, Kandi M, Alaeddini F, et al. Status and trend of deaths due to traffic accidents from 2001 to 2010 in Iran. Iran J Epidemiol. 2015;11(2):13–22.\nBakhtiyari M, Mehmandar MR, Riahi SM, Mansournia MA, Sartipi M, Bahadorimonfared A. Epidemiologic pattern of fatal traffic injuries among Iranian drivers; 2004–2010. Iran J Public Health. 2016;45(4):503–14.\nMoradi A, Rahmani K, Hoshmandi-Shoja M, Rahimi-Sepehr H, Khorshidi A. An overview of the situation of traffic accidents in Iran in comparison with other countries. Iran J Forensic Med. 2016;22(1):45–53.\nDuenas C, Fernandez MC, Canete S, Carretero J, Liger E. Stocastic model to forecast ground level ozone concentration at urban and rural areas. Chemosphere. 2005;61(10):1379–89.\nLin Y, Chen M, Chen G, Wu X, Lin T. Application of an autoregressive integrated moving average model for predicting injury mortality in Xiamen. China BMJ Open. 2015;5(12):1–8.\nBox GEP, Jenkins GM, Reinsel GC, Ljung JM. In: David JB, Noel AC, Garrett MF, editors. Time series analysis: forecasting and control. New Jersey: Wiley; 2016. p. 179–209. Academic.\nMansouri F, Khanjani N, Rananadeh KL, Pourmousa R. Forecasting air pollutant situation using the time series models in Kerman, Iran. Sci J School Pub Health Ins Pub Health Res. 2013;11(2):75–86.\nBahadorimonfared A, Soori H, Mehrabi Y, Rahmati RM, Esmaili AR, Salehi M, et al. Trends of fatal road traffic injuries in Iran (2004–2011). PLoS One. 2013;8(5):1–5.\nBahadori MA, Soori H, Mehrabi Y, Rahmati RM, Esmaili AR, Salehi M, et al. A model for prediction of on the rate of mortality due to road traffic accidents in Iran. Res Med. 2013;36(5):7–11.\nMehmandar MS, Soori H, Mehrabi Y. Predicting and analyzing the trend of traffic accidents deaths in Iran in 2014 and 2015. Int J Crit Illn Inj Sci. 2016;6(2):74–8.\nZolala F, Haghdoost AA, Ahmadijouybari T, Salari A, Bahrampour A, Baneshi MR, et al. Forecasting the trend of traffic accident mortality in West Iran. Health Scope. 2016;5(3):1–5.\nYousefzadeh CS, Ranjbar TF, Malekpouri R, Razzaghi A. A time series model for assessing the trend and forecasting the road traffic accident mortality. Arch Trauma Res. 2016;5(3):1–6.\nRasouli MN, Nouri M, Zarei MR, Saadat S, Rahimi MV. Comparison of road traffic fatalities and injuries in Iran with other countries. Chin J Traumatol. 2008;11(3):131–4.\nSoori H, Royanian M, Zali AR, Movahedinejad A. Study of changes on road traffic injury rates, before and after of four interventions by Iran traffic police. Pajoohandeh J. 2009;14(1):15–20.\nSoori H, Iranfar M. Road traffic status in the world and Iran: review of results from the World Health Organization. J Saf Prom Inj Prev. 2013;1(2):53–62.\nMirzaei M, Mirzadeh M, Shogaei-Far H, Mirzaei M. Trends in road traffic deaths in Yazd, Iran, 2004 - 2010. Arch Trauma Res. 2016;5(2):1–6.\nSadeghi H, Ayubi E, Azami-Aghdash S, Abedi L, Zemestani A, Amanati L, et al. Epidemiological patterns of road traffic crashes during the last two decades in Iran: a review of the literature from 1996 to 2014. Arch Trauma Res. 2016;5(3):1–10.\nJackson TL, Mello MJ. Injury patterns and severity among motorcyclists treated in US emergency departments, 2001–2008: a comparison of younger and older riders. Inj Prev. 2013;19(5):297–302.\nKhorshidi A, Ainy E, Soori H. Epidemiological pattern of road traffic injuries among Iranian motorcyclist in 2012. J Saf Promot Inj Prev. 2016;4(1):47–54.\nLiu BC, Ivers R, Norton R, Boufous S, Blows S, Lo SK. Helmets for preventing injury in motorcycle riders. Cochrane Database Syst Rev. 2008;23:1.\nMokhtari AM, Samadi S, Hatami SE, Jalilian H, Khanjani N. Investigating the rate of helmet use and the related factors among motorcyclist in Kerman between 1391–92. J Saf Prom Inj Prev. 2014;2(3):209–14.\nHeydari SH, Hoseinzadeh A, Sarikhani Y, Hedjazi A, Zarenezhad M, Moafian G, et al. Time analysis of fatal traffic accidents in Fars Province of Iran. Chin J Traumatol. 2013;16(2):84–8.\nHasanzadeh J, Moradinazar M, Najafi F, Ahmadijouybary T. Trends of mortality of road traffic accidents in Fars Province, southern Iran, 2004–2010 Iranian. Aust J Public Health. 2014;43(9):1259–65.\nMohammadian M, Hajare A, Mohammadian HA. Incidence trends of injury and mortality from traffic accidents in urban and suburban areas of Isfahan Province during 2002-2010. J Police Med. 2014;3(1):1–10.",{"EN":1412},"Road traffic accidents are commonly encountered incidents that can cause high-intensity injuries to the victims and have direct impacts on the members of the society. Iran has one of the highest incident rates of road traffic accidents. The objective of this study was to model the patterns of road traffic accidents leading to injury in Kurdistan province, Iran. A time-series analysis was conducted to characterize and predict the frequency of road traffic accidents that lead to injury in Kurdistan province. The injuries were categorized into three separate groups which were related to the car occupants, motorcyclists and pedestrian road traffic accident injuries. The Box-Jenkins time-series analysis was used to model the injury observations applying autoregressive integrated moving average (ARIMA) and seasonal autoregressive integrated moving average (SARIMA) from March 2009 to February 2015 and to predict the accidents up to 24 months later (February 2017). The analysis was carried out using R-3.4.2 statistical software package. A total of 5199 pedestrians, 9015 motorcyclists, and 28,906 car occupants’ accidents were observed. The mean (SD) number of car occupant, motorcyclist and pedestrian accident injuries observed were 401.01 (SD 32.78), 123.70 (SD 30.18) and 71.19 (SD 17.92) per year, respectively. The best models for the pattern of car occupant, motorcyclist, and pedestrian injuries were the ARIMA (1, 0, 0), SARIMA (1, 0, 2) (1, 0, 0)12, and SARIMA (1, 1, 1) (0, 0, 1)12, respectively. The motorcyclist and pedestrian injuries showed a seasonal pattern and the peak was during summer (August). The minimum frequency for the motorcyclist and pedestrian injuries were observed during the late autumn and early winter (December and January). Our findings revealed that the observed motorcyclist and pedestrian injuries had a seasonal pattern that was explained by air temperature changes overtime. These findings call the need for close monitoring of the accidents during the high-risk periods in order to control and decrease the rate of the injuries.",{"EN":1414},"Assessment and prediction of road accident injuries trend using time-series models in Kurdistan",{"VOID":1416},"10.1186\u002Fs41038-018-0111-6","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002Fdoi\u002F10.1186\u002Fs41038-018-0111-6\u002F5680428",[1419,1436,1448,1465,1480,1493,1505],{"id":1420,"sortIndex":222,"researcher":18,"roles":1421,"affiliations":1422,"properties":1433},"56da1a92-af41-4e56-9762-200cce86e60f",[192],[1423],{"id":18,"sortIndex":19,"affiliation":1424,"properties":18},{"id":1425,"createTime":1426,"updateTime":1427,"relativeEntities":1428,"slug":1429,"properties":1430,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"73ca53c0-7517-47db-953d-253338ea0d95","2023-12-03T14:21:05.793+00:00","2025-01-30T16:42:19.936+00:00",[],"Social-Determinants-of-Health-Research-Center-Kurdistan-University-of-Medical-Sciences-Sanandaj-Iran",{"title":1431},{"VI":1432},"Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran",{"title":1434},{"VI":1435},"Asrin Karimi",{"id":1437,"sortIndex":19,"researcher":18,"roles":1438,"affiliations":1439,"properties":1445},"bdaa1691-4717-4495-89ed-f1ce6287683d",[192],[1440],{"id":18,"sortIndex":19,"affiliation":1441,"properties":18},{"id":1425,"createTime":1426,"updateTime":1427,"relativeEntities":1442,"slug":1429,"properties":1443,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1444},{"VI":1432},{"title":1446},{"VI":1447},"Maryam Parvareh",{"id":1449,"sortIndex":262,"researcher":18,"roles":1450,"affiliations":1451,"properties":1462},"2593dc64-7095-4962-982b-50ada304a72e",[192],[1452],{"id":18,"sortIndex":19,"affiliation":1453,"properties":18},{"id":1454,"createTime":1455,"updateTime":1456,"relativeEntities":1457,"slug":1458,"properties":1459,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"a2a528a8-57a9-472d-93fc-98cf29d962ce","2023-12-27T16:28:44.522+00:00","2025-01-30T16:42:19.307+00:00",[],"Research-Center-for-Environmental-Determinants-of-Health-Kermanshah-University-of-Medical-Sciences-Kermanshah-Iran",{"title":1460},{"VI":1461},"Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran",{"title":1463},{"VI":1464},"Satar Rezaei",{"id":1466,"sortIndex":144,"researcher":18,"roles":1467,"affiliations":1468,"properties":1477},"26a67778-cecc-48f6-b326-afe023952ad3",[192],[1469],{"id":18,"sortIndex":19,"affiliation":1470,"properties":18},{"id":1471,"createTime":1472,"updateTime":1472,"relativeEntities":1473,"slug":18,"properties":1474,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"21c25af3-f24a-4082-925f-b2d996c031f8","2024-01-08T10:55:32.673+00:00",[],{"title":1475},{"VI":1476},"School of Public Health, College of Health Sciences, Mekelle University, Tigray, Ethiopia",{"title":1478},{"VI":1479},"Abraha Woldemichael",{"id":1481,"sortIndex":1482,"researcher":18,"roles":1483,"affiliations":1484,"properties":1490},"e2287ca4-6ac9-4ce8-a2bf-2869a212c980",6,[192],[1485],{"id":18,"sortIndex":19,"affiliation":1486,"properties":18},{"id":1425,"createTime":1426,"updateTime":1427,"relativeEntities":1487,"slug":1429,"properties":1488,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1489},{"VI":1432},{"title":1491},{"VI":1492},"Nader Esmail Nasab",{"id":1494,"sortIndex":190,"researcher":18,"roles":1495,"affiliations":1496,"properties":1502},"7a0fe8b5-ac8c-4d99-ab25-d51cfd65479c",[192],[1497],{"id":18,"sortIndex":19,"affiliation":1498,"properties":18},{"id":1425,"createTime":1426,"updateTime":1427,"relativeEntities":1499,"slug":1429,"properties":1500,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1501},{"VI":1432},{"title":1503},{"VI":1504},"Bijan Nouri",{"id":1506,"sortIndex":80,"researcher":18,"roles":1507,"affiliations":1508,"properties":1519},"1e7bdf30-97fd-4593-b9e8-4de59e69dbc6",[192],[1509],{"id":18,"sortIndex":19,"affiliation":1510,"properties":18},{"id":1511,"createTime":1512,"updateTime":1513,"relativeEntities":1514,"slug":1515,"properties":1516,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"001004b1-4882-430e-86fa-ac3d4e2bc06c","2024-01-25T12:52:39.128+00:00","2025-06-11T13:34:28.232+00:00",[],"Department-of-Epidemiology-and-Biostatistics-School-of-Public-Health-Kerman-University-of-Medical-Health-Kerman-Iran",{"title":1517},{"VI":1518},"Department of Epidemiology and Biostatistics, School of Public Health, Kerman University of Medical Health, Kerman, Iran",{"title":1520},{"VI":1521},"Sairan Nili",{"url":1417,"publisher":1523,"properties":1550},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1524,"slug":10,"properties":1525,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1528,"manageAffiliations":1529,"indexDatabases":1530,"url":18,"thumbnailPath":18,"statistic":1545,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1526,"title":1527},{"VOID":13},{"EN":15},[],[],[1531,1538],{"id":94,"indexDatabase":1532,"url":107,"indexYears":108,"academicFieldIds":1537,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":1533,"label":1534,"description":1535,"key":104,"publicationTags":1536,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":1539,"url":18,"indexYears":18,"academicFieldIds":1544,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":1540,"label":1541,"description":1542,"key":128,"publicationTags":1543,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":1546,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":1547,"totalCitation":151,"totalCitationByYear":1548,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":1549,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":1551,"pages":1553},{"VOID":1552},"6",{"VOID":306},"2018-03-09",2018,{"id":1557,"createTime":1558,"updateTime":1559,"relativeEntities":1560,"slug":1561,"properties":1562,"entityType":183,"verifyStatus":184,"verifyTime":1559,"verifyNote":185,"syncStatus":17,"languages":1578,"translateLanguages":18,"viewCount":19,"primaryUrl":1579,"fullTextUrl":18,"authors":1580,"publicationType":273,"publisherRelationship":1635,"citationCount":262,"citationInfo":1663,"publishDate":1665,"publishYear":308,"citationAnalyzeStatus":1666,"lastCitationAnalyze":1667,"indexDatabases":18,"openAccess":18,"references":1668,"isForceReanalyzing":309},"954cdee0-bf51-481a-a6d9-581a7a56feac","2024-04-11T15:05:35.686+00:00","2025-02-02T23:15:44.402+00:00",[],"Unstable-cardiac-injury-complicated-with-septic-shock-a-challenge",{"mag":1563,"keywords":1565,"pmc":1566,"openalex":1568,"abstract":1570,"title":1572,"pm":1574,"doi":1576},{"VOID":1564},"2326507669",{},{"VOID":1567},"4963929",{"VOID":1569},"W2326507669",{"EN":1571},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n               \u003Cjats:sec>\n                  \u003Cjats:title>Background\u003C\u002Fjats:title>\n                  \u003Cjats:p>Road traffic accident accounts for 70 % to 80 % of the blunt cardiac injury. The true incidence varies in the literature due to non-uniform criteria for diagnosis.\u003C\u002Fjats:p>\n               \u003C\u002Fjats:sec>\n               \u003Cjats:sec>\n                  \u003Cjats:title>Case Presentation\u003C\u002Fjats:title>\n                  \u003Cjats:p>Here, we describe the case of a young male presenting after blunt chest injury and hemodynamic instability. Initially, the patient had frequent episodes of arrhythmias and hypotension due to cardiac injury per se. However, he was stabilized by day 2. Subsequently, patient developed cellulitis followed by septic shock and succumbed to cellulitis on day 5 of injury.\u003C\u002Fjats:p>\n               \u003C\u002Fjats:sec>\n               \u003Cjats:sec>\n                  \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n                  \u003Cjats:p>Sepsis is difficult to be diagnosed and treated in the presence of cardiac injury. Myocardial depression has been found in sepsis, which contributes as an added comorbidity in an already compromised heart function. Sepsis also interferes with the diagnosis and follow-up of progress of blunt cardiac injury.\u003C\u002Fjats:p>\n               \u003C\u002Fjats:sec>",{"EN":1573},"Unstable cardiac injury complicated with septic shock—a challenge",{"VOID":1575},"27574681",{"VOID":1577},"10.1186\u002Fs41038-016-0035-y",[772],"https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002Fdoi\u002F10.1186\u002Fs41038-016-0035-y\u002F5670996",[1581,1601,1619],{"id":1582,"sortIndex":19,"researcher":18,"roles":1583,"affiliations":1584,"properties":1594},"3129f278-daa4-4177-8184-039b67712c96",[],[1585],{"id":18,"sortIndex":19,"affiliation":1586,"properties":18},{"id":1587,"createTime":1588,"updateTime":1588,"relativeEntities":1589,"slug":1590,"properties":1591,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"bb59fc25-91bf-411f-b055-0e0644f1d2d8","2024-04-11T15:05:35.696+00:00",[],"Department-of-Anaesthesia-and-Intensive-Care-All-India-Institute-of-Medical-Sciences-Ansari-Nagar-East-Gautam-Nagar-110029-New-Delhi-India",{"title":1592},{"EN":1593},"Department of Anaesthesia and Intensive Care All India Institute of Medical Sciences Ansari Nagar East, Gautam Nagar 110029 New Delhi, India",{"openalex":1595,"orcid":1597,"title":1599},{"VOID":1596},"A5059911286",{"VOID":1598},"https:\u002F\u002Forcid.org\u002F0000-0003-2227-8292",{"EN":1600},"Neha Garg",{"id":1602,"sortIndex":262,"researcher":18,"roles":1603,"affiliations":1604,"properties":1614},"9ff7ba92-3efe-4d22-82e1-71bfe14a834e",[],[1605],{"id":18,"sortIndex":19,"affiliation":1606,"properties":18},{"id":1607,"createTime":1608,"updateTime":1608,"relativeEntities":1609,"slug":1610,"properties":1611,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"35d5925e-3e4c-4f4a-b7af-edf5beb3eabb","2024-04-11T15:05:35.743+00:00",[],"Division-of-Critical-Intensive-care-All-India-Institute-of-Medical-Sciences-Ansari-Nagar-East-Gautam-Nagar-110029-New-Delhi-India",{"title":1612},{"EN":1613},"Division of Critical & Intensive care All India Institute of Medical Sciences Ansari Nagar East, Gautam Nagar 110029 New Delhi, India",{"openalex":1615,"title":1617},{"VOID":1616},"A5070578045",{"EN":1618},"Richa Aggarwal",{"id":1620,"sortIndex":222,"researcher":18,"roles":1621,"affiliations":1622,"properties":1628},"5ed9b358-3eeb-4a41-bc21-09df3519b729",[],[1623],{"id":18,"sortIndex":19,"affiliation":1624,"properties":18},{"id":1607,"createTime":1608,"updateTime":1608,"relativeEntities":1625,"slug":1610,"properties":1626,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1627},{"EN":1613},{"openalex":1629,"orcid":1631,"title":1633},{"VOID":1630},"A5008995324",{"VOID":1632},"https:\u002F\u002Forcid.org\u002F0000-0002-3586-6213",{"EN":1634},"Kapil Dev Soni",{"url":18,"publisher":1636,"properties":18},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1637,"slug":10,"properties":1638,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1641,"manageAffiliations":1642,"indexDatabases":1643,"url":18,"thumbnailPath":18,"statistic":1658,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1639,"title":1640},{"VOID":13},{"EN":15},[],[],[1644,1651],{"id":94,"indexDatabase":1645,"url":107,"indexYears":108,"academicFieldIds":1650,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":1646,"label":1647,"description":1648,"key":104,"publicationTags":1649,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":1652,"url":18,"indexYears":18,"academicFieldIds":1657,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":1653,"label":1654,"description":1655,"key":128,"publicationTags":1656,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":1659,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":1660,"totalCitation":151,"totalCitationByYear":1661,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":1662,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"total":262,"publishYear":18,"statisticByYear":1664},{"2019":262},"2016-12-01","ERROR_IN_ANALYZE_CITATION","2024-04-11T17:12:19.284+00:00",[1669,1673,1677,1681,1685,1689,1693,1697,1701,1705,1709],{"id":18,"text":1670,"url":18,"identifiers":1671},"Wijngaarden, 1997, Blunt cardiac injury: a 10 year institutional review, Injury, 28, 51, 10.1016\u002FS0020-1383(96)00118-0",{"doi":1672},"10.1016\u002FS0020-1383(96)00118-0",{"id":18,"text":1674,"url":18,"identifiers":1675},"Maenza, 1996, A meta-analysis of blunt cardiac trauma: ending myocardial confusion, Am J Emerg Med, 14, 237, 10.1016\u002FS0735-6757(96)90165-5",{"doi":1676},"10.1016\u002FS0735-6757(96)90165-5",{"id":18,"text":1678,"url":18,"identifiers":1679},"Feghali, 1995, Blunt myocardial injury, Chest, 108, 1673, 10.1378\u002Fchest.108.6.1673",{"doi":1680},"10.1378\u002Fchest.108.6.1673",{"id":18,"text":1682,"url":18,"identifiers":1683},"Asensio, 1998, One hundred five penetrating cardiac injuries: a 2 year prospective evaluation, J Trauma, 44, 1973, 10.1097\u002F00005373-199806000-00022",{"doi":1684},"10.1097\u002F00005373-199806000-00022",{"id":18,"text":1686,"url":18,"identifiers":1687},"Salim, 2001, Clinically significant blunt cardiac trauma: role of serum troponin levels combined with electrocardiographic findings, J Trauma, 50, 237, 10.1097\u002F00005373-200102000-00008",{"doi":1688},"10.1097\u002F00005373-200102000-00008",{"id":18,"text":1690,"url":18,"identifiers":1691},"Fernandez, 1998, Role of transesophageal echocardiography in the assessment of patients with blunt chest trauma: correlation of echocardiographic findings with the electrocardiogram and creatine kinase monoclonal antibody measurements, Am Heart J, 135, 476, 10.1016\u002FS0002-8703(98)70324-2",{"doi":1692},"10.1016\u002FS0002-8703(98)70324-2",{"id":18,"text":1694,"url":18,"identifiers":1695},"Velmahos, 2003, Normal electrocardiography and serum troponin I levels preclude the presence of clinically significant blunt cardiac injury, J Trauma, 54, 45, 10.1097\u002F00005373-200301000-00006",{"doi":1696},"10.1097\u002F00005373-200301000-00006",{"id":18,"text":1698,"url":18,"identifiers":1699},"Mohammed, 2011, The clinic al significance of cardiac troponins in medical practice, J Saudi Heart Assoc, 23, 3, 10.1016\u002Fj.jsha.2010.10.001",{"doi":1700},"10.1016\u002Fj.jsha.2010.10.001",{"id":18,"text":1702,"url":18,"identifiers":1703},"Skorton, 1983, Quantitative texture analysis in two-dimensional echocardiography: application to the diagnosis of experimental myocardial contusion, Circulation, 68, 217, 10.1161\u002F01.CIR.68.1.217",{"doi":1704},"10.1161\u002F01.CIR.68.1.217",{"id":18,"text":1706,"url":18,"identifiers":1707},"Krishnagopalan, 2002, Myocardial dysfunction in the patient with sepsis, Curr Opin Crit Care, 8, 376, 10.1097\u002F00075198-200210000-00003",{"doi":1708},"10.1097\u002F00075198-200210000-00003",{"id":18,"text":1710,"url":18,"identifiers":1711},"Ashraf, 2012, Cardiac functions in patients with sepsis and septic shock, Egyptian Heart J, 64, 191, 10.1016\u002Fj.ehj.2012.07.002",{"doi":1712},"10.1016\u002Fj.ehj.2012.07.002",{"id":1714,"createTime":1715,"updateTime":1716,"relativeEntities":1717,"slug":1718,"properties":1719,"entityType":183,"verifyStatus":184,"verifyTime":1716,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1728,"fullTextUrl":18,"authors":1729,"publicationType":273,"publisherRelationship":1767,"citationCount":18,"citationInfo":18,"publishDate":1799,"publishYear":425,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"f8bca8c6-3b53-4963-a183-a0889d044a5c","2024-01-18T03:54:15.003+00:00","2025-01-24T23:04:19.139+00:00",[],"Current-progress-of-skin-tissue-engineering-Seed-cells-bioscaffolds-and-construction-strategies",{"references":1720,"abstract":1722,"title":1724,"doi":1726},{"VOID":1721},"Shevchenko RV, James SL, James SE. A review of tissue-engineered skin bioconstructs available for skin reconstruction. J R Soc Interface 2010;7:229–58.\nRheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 1975;6:331–43.\nBottcher-Haberzeth S, Biedermann T, Reichmann E. Tissue engineering of skin. Burns 2010;36:450–60.\nAbbas O, Mahalingam M. Epidermal stem cells: Practical perspectives and potential uses. Br J Dermatol 2009;161:228–36.\nWood FM, Kolybaba ML, Allen P. The use of cultured epithelial autograft in the treatment of major burn wounds: Eleven years of clinical experience. Burns 2006;32:538–44.\nClugston PA, Snelling CF, Macdonald IB, Maledy HL, Boyle JC, Germann E, et al. Cultured epithelial autografts: Three years of clinical experience with eighteen patients. J Burn Care Rehabil 1991;12:533-9.\nLootens L, Brusselaers N, Beele H, Monstrey S. Keratinocytes in the treatment of severe burn injury: An update. Int Wound J 2013;10:6–12.\nCuono C, Langdon R, McGuire J. Use of cultured epidermal autografts and dermal allografts as skin replacement after burn injury. Lancet 1986;1:1123–4.\nButler CE, Orgill DP. Simultaneous in vivo regeneration of neodermis, epidermis, and basement membrane. Adv Biochem Eng Biotechnol 2005;94:23–41.\nDuan H, Feng B, Guo X, Wang J, Zhao L, Zhou G, et al. Engineering of epidermis skin grafts using electrospun nanofibrous gelatin\u002F polycaprolactone membranes. Int J Nanomedicine 2013;8:2077–84.\nCurrie LJ, Sharpe JR, Martin R. The use of fibrin glue in skin grafts and tissue-engineered skin replacements: A review. Plast Reconstr Surg 2001;108:1713–26.\nHowling GI, Dettmar PW, Goddard PA, Hampson FC, Dornish M, Wood EJ. The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. Biomaterials 2001;22:2959–66.\nKao B, Kadomatsu K, Hosaka Y. Construction of synthetic dermis and skin based on a self-assembled peptide hydrogel scaffold. Tissue Eng Part A 2009;15:2385–96.\nBlackwood KA, McKean R, Canton I, Freeman CO, Franklin KL, Cole D, et al. Development of biodegradable electrospun scaffolds for dermal replacement. Biomaterials 2008;29:3091–104.\nSarkar SD, Farrugia BL, Dargaville TR, Dhara S. Chitosan-collagen scaffolds with nano\u002Fmicrofibrous architecture for skin tissue engineering. J Biomed Mater Res A 2013.\nSun T, Jackson S, Haycock JW, MacNeil S. Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents. J Biotechnol 2006;122:372–81.\nSun T, Mai S, Norton D, Haycock JW, Ryan AJ, MacNeil S. Self-organization of skin cells in three-dimensional electrospun polystyrene scaffolds. Tissue Eng 2005;11:1023–33.\nel-Ghalbzouri A, Gibbs S, Lamme E, Van Blitterswijk CA, Ponec M. Effect of fibroblasts on epidermal regeneration. Br J Dermatol 2002;147:230–43.\nSonnemann KJ, Bement WM. Wound repair: Toward understanding and integration of single-cell and multicellular wound responses. Annu Rev Cell Dev Biol 2011;27:237–63.\nBlanpain C. Stem cells: Skin regeneration and repair. Nature 2010;464:686–7.\nIkuta S, Sekino N, Hara T, Saito Y, Chida K. Mouse epidermal keratinocytes in three-dimensional organotypic coculture with dermal fibroblasts form a stratified sheet resembling skin. Biosci Biotechnol Biochem 2006;70:2669–75.\nZhang CP, Fu XB. Therapeutic potential of stem cells in skin repair and regeneration. Chin J Traumatol 2008;11:209–21.\nFernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabe-Heider F, et al. A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol 2004;6:1082–93.\nIto M, Liu Y, Yang Z, Nguyen J, Liang F, Morris RJ, et al. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med 2005;11:1351–4.\nDunnwald M, Tomanek-Chalkley A, Alexandrunas D, Fishbaugh J, Bickenbach JR. Isolating a pure population of epidermal stem cells for use in tissue engineering. Exp Dermatol 2001;10:45–54.\nLei XH, Ning LN, Cao YJ, Liu S, Zhang SB, Qiu ZF, et al. NASA-approved rotary bioreactor enhances proliferation of human epidermal stem cells and supports formation of 3D epidermis-like structure. PloS One 2011;6:e26603.\nStenn KS, Cotsarelis G Bioengineering the hair follicle: Fringe benefits of stem cell technology. Curr Opin Biotechnol 2005;16:493–7.\nGagnon V, Larouche D, Parenteau-Bareil R, Gingras M, Germain L, Berthod F Hair follicles guide nerve migration in vitro and in vivo in tissue-engineered skin. J Invest Dermatol 2011;131:1375–8.\nRehder J, Souto LR, Issa CM, Puzzi MB. Model of human epidermis reconstructed in vitro with keratinocytes and melanocytes on dead de-epidermized human dermis. Sao Paulo Med J 2004;122:22–5.\nLiu Y, Suwa F, Wang X, Takemura A, Fang YR, Li Y, et al. Reconstruction of a tissue-engineered skin containing melanocytes. Cell Biol Int 2007;31:985–90.\nHachiya A, Sriwiriyanont P, Kaiho E, Kitahara T, Takema Y, Tsuboi R. An in vivo mouse model of human skin substitute containing spontaneously sorted melanocytes demonstrates physiological changes after UVB irradiation. J Invest Dermatol 2005;125:364–72.\nMetallo CM, Ji L, de Pablo JJ, Palecek SP. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells 2008;26:372–80.\nAberdam E, Barak E, Rouleau M, de LaForest S, Berrih-Aknin S, Suter DM, et al. A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells 2008;26:440–4.\nInanc B, Elcin AE, Unsal E, Balos K, Parlar A, Elcin YM. Differentiation of human embryonic stem cells on periodontal ligament fibroblasts in vitro. Artif Organs 2008;32:100–9.\nMetallo CM, Azarin SM, Moses LE, Ji L, de Pablo JJ, Palecek SP. Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs. Tissue Eng Part A 2010;16:213–23.\nHewitt KJ, Shamis Y, Carlson MW, Aberdam E, Aberdam D, Garlick JA. Three-dimensional epithelial tissues generated from human embryonic stem cells. Tissue Eng Part A 2009;15:3417–26.\nGuenou H, Nissan X, Larcher F, Feteira J, Lemaitre G, Saidani M, et al. Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: A preclinical study. Lancet 2009;374:1745–53.\nHan YF, Tao R, Sun TJ, Chai JK, Xu G, Liu J. Advances and opportunities for stem cell research in skin tissue engineering. Eur Rev Med Pharmacol Sci 2012;16:1873–7.\nTakahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663–76.\nQi H, Pei D. The magic of four: Induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4. Cell Res 2007;17:578–80.\nBilousova G, Chen J, Roop DR. Differentiation of mouse induced pluripotent stem cells into a multipotent keratinocyte lineage. J Invest Dermatol 2011;131:857–64.\nSakurai M, Hayashi R, Kageyama T, Yamato M, Nishida K. Induction of putative stratified epithelial progenitor cells in vitro from mouse-induced pluripotent stem cells. J Artif Organs 2011;14:58–66.\nTolar J, Xia L, Riddle MJ, Lees CJ, Eide CR, McElmurry RT, et al. Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa. J Invest Dermatol 2011;131:848–56.\nOkita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008;322:949–53.\nUitto J. Regenerative medicine for skin diseases: iPS cells to the rescue. J Invest Dermatol 2011;131:812–4.\nVogel G. Stem cells. Diseases in a dish take off. Science 2010;330:1172–3.\nBadylak SF, Taylor D, Uygun K. Whole-organ tissue engineering: Decellularization and recellularization of three-dimensional matrix scaffolds. Annu Rev Biomed Eng 2011;13:27–53.\nHodgkinson T, Bayat A. Dermal substitute-assisted healing: Enhancing stem cell therapy with novel biomaterial design. Arch Dermatol Res 2011;303:301–15.\nWu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007;25:2648–59.\nLi H, Fu X, Ouyang Y, Cai C, Wang J, Sun T. Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages. Cell Tissue Res 2006;326:725–36.\nCaplan AI. Why are MSCs therapeutic? New data: New insight. J Pathol 2009;217:318–24.\nRasmusson I, Le Blanc K, Sundberg B, Ringden O. Mesenchymal stem cells stimulate antibody secretion in human B cells. Scand J Immunol 2007;65:336–43.\nSchneider RK, Neuss S, Stainforth R, Laddach N, Bovi M, Knuechel R, et al. Three-dimensional epidermis-like growth of human mesenchymal stem cells on dermal equivalents: Contribution to tissue organization by adaptation of myofibroblastic phenotype and function. Differentiation 2008;76:156–67.\nSchneider RK, Puellen A, Kramann R, Raupach K, Bornemann J, Knuechel R, et al. The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials 2010;31:467–80.\nLiu P, Deng Z, Han S, Liu T, Wen N, Lu W, et al. Tissue-engineered skin containing mesenchymal stem cells improves burn wounds. Artif Organs 2008;32:925–31.\nHuang SP, Hsu CC, Chang SC, Wang CH, Deng SC, Dai NT, et al. Adipose-derived stem cells seeded on acellular dermal matrix grafts enhance wound healing in a murine model of a full-thickness defect. Ann Plast Surg 2012;69:656–62.\nLiu S, Zhang H, Zhang X, Lu W, Huang X, Xie H, et al. Synergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repair. Tissue Eng Part A 2011;17:725–39.\nHendrickx B, Vranckx JJ, Luttun A. Cell-based vascularization strategies for skin tissue engineering. Tissue Eng Part B Rev 2011;17:13–24.\nZhang X, Yang J, Li Y, Liu S, Long K, Zhao Q, et al. Functional neovascularization in tissue engineering with porcine acellular dermal matrix and human umbilical vein endothelial cells. Tissue Eng Part C Methods 2011;17:423–33.\nHudon V, Berthod F, Black AF, Damour O, Germain L, Auger FA. A tissue-engineered endothelialized dermis to study the modulation of angiogenic and angiostatic molecules on capillary-like tube formation in vitro. Br J Dermatol 2003;148:1094–104.\nKunz-Schughart LA, Schroeder JA, Wondrak M, van Rey F, Lehle K, Hofstaedter F, et al. Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. Am J Physiol Cell Physiol 2006;290:C1385–98.\nLiu Y, Luo H, Wang X, Takemura A, Fang YR, Jin Y, et al. In vitro construction of scaffold-free bilayered tissue-engineered skin containing capillary networks. Biomed Res Int 2013;2013:561410.\nKesting MR, Wolff KD, Hohlweg-Majert B, Steinstraesser L. The role of allogenic amniotic membrane in burn treatment. J Burn Care Res 2008;29:907–16.\nShimmura S, Shimazaki J, Ohashi Y, Tsubota K. Antiinflammatory effects of amniotic membrane transplantation in ocular surface disorders. Cornea 2001;20:408–13.\nLi H, Chu Y, Zhang Z, Zhang G, Jiang L, Wu H, et al. Construction of bilayered tissue-engineered skin with human 71 amniotic mesenchymal cells and human amniotic epithelial cells. Artif Organs 2012;36:911–9.\nHartmann-Fritsch F, Hosper N, Luginbuhl J, Biedermann T, Reichmann E, Meuli M. Human amniotic fluid derived cells can competently substitute dermal fibroblasts in a tissue-engineered dermo-epidermal skin analog. Pediatr Surg Int 2013;29:61–9.\nRuszczak Z. Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev 2003;55:1595–611.\nShin H, Jo S, Mikos AG. Biomimetic materials for tissue engineering. Biomaterials 2003;24:4353-64.\nNam K, Kimura T, Funamoto S, Kishida A. Preparation of a collagen\u002Fpolymer hybrid gel designed for tissue membranes. Part I: Controlling the polymer-collagen cross-linking process using an ethanol\u002Fwater co-solvent. Acta Biomater 2010;6:403–8.\nWeadock KS, Miller EJ, Keuffel EL, Dunn MG. Effect of physical crosslinking methods on collagen-fiber durability in proteolytic solutions. J Biomed Mater Res 1996;32:221–6.\nWang HM, Chou YT, Wen ZH, Wang ZR, Chen CH, Ho ML. Novel biodegradable porous scaffold applied to skin regeneration. PloS One 2013;8:e56330.\nFaraj KA, van Kuppevelt TH, Daamen WF Construction of collagen scaffolds that mimic the three-dimensional architecture of specific tissues. Tissue Eng 2007;13:2387–94.\nRnjak-Kovacina J, Wise SG, Li Z, Maitz PK, Young CJ, Wang Y, et al. Electrospun synthetic human elastin: Collagen composite scaffolds for dermal tissue engineering. Acta Biomater 2012;8:3714–22.\nNillesen ST, Geutjes PJ, Wismans R, Schalkwijk J, Daamen WF, van Kuppevelt TH. Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF. Biomaterials 2007;28:1123–31.\nLynn AK, Yannas IV, Bonfield W. Antigenicity and immunogenicity of collagen. J Biomed Mater Res B Appl Biomater 2004;71:343–54.\nLee CH, Singla A, Lee Y. Biomedical applications of collagen. Int J Pharm 2001;221:1–22.\nKhor HL, Ng KW, Schantz JT, Phan TT, Lim TC, Teoh SH, et al. Poly (?-caprolactone) films as a potential substrate for tissue engineering an epidermal equivalent. Mater Sci Eng C 2002;20:71–5.\nSun T, Haycock J, MacNeil S. In situ image analysis of interactions between normal human keratinocytes and fibroblasts cultured in three-dimensional fibrin gels. Biomaterials 2006;27:3459–65.\nWang TW, Sun JS, Wu HC, Tsuang YH, Wang WH, Lin FH. The effect of gelatin-chondroitin sulfate-hyaluronic acid skin substitute on wound healing in SCID mice. Biomaterials 2006;27:5689–97.\nLee SB, Kim YH, Chong MS, Hong SH, Lee YM. Study of gelatin-containing artificial skin V: Fabrication of gelatin scaffolds using a salt-leaching method. Biomaterials 2005;26:1961–8.\nMeana A, Iglesias J, Del Rio M, Larcher F, Madrigal B, Fresno M, et al. Large surface of cultured human epithelium obtained on a dermal matrix based on live fibroblast-containing fibrin gels. Burns 1998;24:621–30.\nHodgkinson T, Bayat A. Dermal substitute-assisted healing: Enhancing stem cell therapy with novel biomaterial design. Arch Dermatol Res 2011;303:301–15.\nChun YS, Verma K, Rosen H, Lipsitz S, Morris D, Kenney P, et al. Implant-based breast reconstruction using acellular dermal matrix and the risk of postoperative complications. Plast Reconstr Surg 2010;125:429–36.\nAskari M, Cohen MJ, Grossman PH, Kulber DA. The use of acellular dermal matrix in release of burn contracture scars in the hand. Plast Reconstr Surg 2011;127:1593–9.\nGe L, Zheng S, Wei H. Comparison of histological structure and biocompatibility between human acellular dermal matrix (ADM) and porcine ADM. Burns 2009;35:46–50.\nDerwin KA, Badylak SF, Steinmann SP, Iannotti JP. Extracellular matrix scaffold devices for rotator cuff repair. J Shoulder Elbow Surg 2010;19:467–76.\nReing JE, Zhang L, Myers-Irvin J, Cordero KE, Freytes DO, Heber-Katz E, et al. Degradation products of extracellular matrix affect cell migration and proliferation. Tissue Eng Part A 2009;15:605–14.\nChen RN, Ho HO, Tsai YT, Sheu MT. Process development of an acellular dermal matrix (ADM) for biomedical applications. Biomaterials 2004;25:2679–86.\nCallcut R, Schurr M, Sloan M, Faucher L. Clinical experience with Alloderm: A one-staged composite dermal\u002Fepidermal replacement utilizing processed cadaver dermis and thin autografts. Burns 2006;32:583–8.\nZhang X, Deng Z, Wang H, Yang Z, Guo W, Li Y, et al. Expansion and delivery of human fibroblasts on micronized acellular dermal matrix for skin regeneration. Biomaterials 2009;30:2666–74.\nSanders J, Stiles C, Hayes C. Tissue response to single-polymer fibers of varying diameters: Evaluation of fibrous encapsulation and macrophage density. J Biomed Mater Res 2000;52:231–7.\nDai W, Kawazoe N, Lin X, Dong J, Chen G. The influence of structural design of PLGA\u002Fcollagen hybrid scaffolds in cartilage tissue engineering. Biomaterials 2010;31:2141–52.\nChen X, Qi YY, Wang LL, Yin Z, Yin GL, Zou XH, et al. Ligament regeneration using a knitted silk scaffold combined with collagen matrix. Biomaterials 2008;29:3683–92.\nChen G, Sato T, Ohgushi H, Ushida T, Tateishi T, Tanaka J. Culturing of skin fibroblasts in a thin PLGA-collagen hybrid mesh. Biomaterials 2005;26:2559–66.\nLin HY, Kuo YJ, Chang SH, Ni TS. Characterization of electrospun nanofiber matrices made of collagen blends as potential skin substitutes. Biomed Mater 2013;8:025009.\nCui W, Zhu X, Yang Y, Li X, Jin Y. Evaluation of electrospun fibrous scaffolds of poly (dl-lactide) and poly (ethylene glycol) for skin tissue engineering. Mater Sci Eng C 2009;29:1869–76.\nMa G, Yang D, Wang K, Han J, Ding S, Song G, et al. Organic?soluble chitosan\u002Fpolyhydroxybutyrate ultrafine fibers as skin regeneration prepared by electrospinning. J Appl Polym Sci 2010;118:3619–24.\nLammers G, Tjabringa GS, Schalkwijk J, Daamen WF, van Kuppevelt TH. A molecularly defined array based on native fibrillar collagen for the assessment of skin tissue engineering biomaterials. Biomaterials 2009;30:6213–20.\nYliperttula M, Chung BG, Navaladi A, Manbachi A, Urtti A. High-throughput screening of cell responses to biomaterials. Eur J Pharm Sci 2008;35:151–60.\nKennedy SB, Washburn NR, Simon CG Jr, Amis EJ. Combinatorial screen of the effect of surface energy on fibronectin-mediated osteoblast adhesion, spreading and proliferation. Biomaterials 2006;27:3817–24.\nMacNeil S. Progress and opportunities for tissue-engineered skin. Nature 2007;445:874–80.\nNavarro FA, Stoner ML, Park CS, Huertas JC, Lee HB, Wood FM, et al. Sprayed keratinocyte suspensions accelerate 72 epidermal coverage in a porcine microwound model. J Burn Care Rehabil 2000;21:513–8.\nHaddow DB, Steele DA, Short RD, Dawson RA, Macneil S. Plasma-polymerized surfaces for culture of human keratinocytes and transfer of cells to an in vitro wound-bed model. J Biomed Mater Res A 2003;64:80–7.\nWright KA, Nadire KB, Busto P, Tubo R, McPherson JM, Wentworth BM. Alternative delivery of keratinocytes using a polyurethane membrane and the implications for its use in the treatment of full-thickness burn injury. Burns 1998;24:7–17.\nTausche AK, Skaria M, Bohlen L, Liebold K, Hafner J, Friedlein H, et al. An autologous epidermal equivalent tissue-engineered from follicular outer root sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers. Wound Repair Regen 2003;11:248–52.\nVaillant L. Treatment of venous leg ulcers with Epibase. A prospective study. Preliminary results. Ann Dermatol Venereol 2002;129:1245–6.\nHeimbach DM. A nonuser’s questions about cultured epidermal autograft. J Burn Care Rehabil 1992;13:127–9.\nWainwright D. Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns 1995;21:243-8.\nBond JL, Dopirak RM, Higgins J, Burns J, Snyder SJ. Arthroscopic replacement of massive, irreparable rotator cuff tears using a GraftJacket allograft: Technique and preliminary results. Arthroscopy 2008;24:403–9 e1.\nRyssel H, Gazyakan E, Germann G, Öhlbauer M. The use of MatriDerm® in early excision and simultaneous autologous skin grafting in burns-A pilot study. Burns 2008;34:93–7.\nHeimbach DM, Warden GD, Luterman A, Jordan MH, Ozobia N, Ryan CM, et al. Multicenter postapproval clinical trial of Integra dermal regeneration template for burn treatment. J Burn Care Rehabil 2003;24:42–8.\nFeldman DL, Rogers A, Karpinski RH. A prospective trial comparing Biobrane, Duoderm and xeroform for skin graft donor sites. Surg Gynecol Obstet 1991;173:1–5.\nGravante G, Delogu D, Giordan N, Morano G, Montone A, Esposito G. The use of Hyalomatrix PA in the treatment of deep partial-thickness burns. J Burn Care Res 2007;28:269–74.\nGentzkow GD, Iwasaki SD, Hershon KS, Mengel M, Prendergast JJ, Ricotta JJ, et al. Use of dermagraft, a cultured human dermis, to treat diabetic foot ulcers. Diabetes Care 1996;19:350–4.\nNoordenbos J, Dore C, Hansbrough JF. Safety and efficacy of TransCyte for the treatment of partial-thickness burns. J Burn Care Rehabil 1999;20:275–81.\nFalanga V, Sabolinski M. A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen 1999;7:201–7.\nEl Ghalbzouri A, Commandeur S, Rietveld MH, Mulder AA, Willemze R. Replacement of animal-derived collagen matrix by human fibroblast-derived dermal matrix for human skin equivalent products. Biomaterials 2009;30:71–8.\nDong R, Liu X, Liu Y, Deng Z, Nie X, Wang X, et al. Enrichment of epidermal stem cells by rapid adherence and analysis of the reciprocal interaction of epidermal stem cells with neighboring cells using an organotypic system. Cell Biol Int 2007;31:733–40.\nAoki S, Takezawa T, Uchihashi K, Sugihara H, Toda S. Non-skin mesenchymal cell types support epidermal regeneration in a mesenchymal stem cell or myofibroblast phenotype-independent manner. Pathol Int 2009;59:368–75.\nNie X, Cai JK, Yang HM, Xiao HA, Wang JH, Wen N, et al. Successful application of tissue-engineered skin to refractory ulcers. Clin Exp Dermatol 2007;32:699–701.\nMartinez-Santamaria L, Guerrero-Aspizua S, Del Rio M. Skin bioengineering: Preclinical and clinical applications. Actas Dermosifiliogr 2012;103:5–11.\nMahjour SB, Ghaffarpasand F, Wang H. Hair follicle regeneration in skin grafts: Current concepts and future perspectives. Tissue Eng Part B Rev 2012;18:15–23.\nBlais M, Grenier M, Berthod F. Improvement of nerve regeneration in tissue-engineered skin enriched with schwann cells. J Invest Dermatol 2009;129:2895–900.\nMonfort A, Soriano-Navarro M, Garcia-Verdugo JM, Izeta A. Production of human tissue-engineered skin trilayer on a plasma-based hypodermis. J Tissue Eng Regen Med 2013;7:479–90.\nLiu F, Luo XS, Shen HY, Dong JS, Yang J. Using human hair follicle-derived keratinocytes and melanocytes for constructing pigmented tissue-engineered skin. Skin Res Technol 2011;17:373–9.\nPeng LH, Mao ZY, Qi XT, Chen X, Li N, Tabata Y, et al. Transplantation of bone-marrow-derived mesenchymal and epidermal stem cells contribute to wound healing with different regenerative features. Cell Tissue Res 2013;352:573–83.\nAltman AM, Matthias N, Yan Y, Song YH, Bai X, Chiu ES, et al. Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials 2008;29:1431–42.\nLu W, Yu J, Zhang Y, Ji K, Zhou Y, Li Y, et al. Mixture of fibroblasts and adipose tissue-derived stem cells can improve epidermal morphogenesis of tissue-engineered skin. Cells Tissues Organs 2012;195:197–206.\nGriffiths M, Ojeh N, Livingstone R, Price R, Navsaria H. Survival of Apligraf in acute human wounds. Tissue Eng 2004;10:1180–95.",{"EN":1723},"The development of cell biology, molecular biology, and material science, has been propelling biomimic tissue-engineered skins to become more sophisticated in scientificity and more simplified in practicality. In order to improve the safety, durability, elasticity, biocompatibility, and clinical efficacy of tissue-engineered skin, several powerful seed cells have already found their application in wound repair, and a variety of bioactive scaff olds have been discovered to influence cell fate in epidermogenesis. These exuberant interests provide insights into advanced construction strategies for complex skin mimics. Based on these exciting developments, a complete full-thickness tissue-engineered skin is likely to be generated.",{"EN":1725},"Current progress of skin tissue engineering: Seed cells, bioscaffolds, and construction strategies",{"VOID":1727},"10.4103\u002F2321-3868.118928","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002F1\u002F2\u002F2321-3868.118928\u002F5650461",[1730,1755],{"id":1731,"sortIndex":222,"researcher":18,"roles":1732,"affiliations":1733,"properties":1752},"80d4cc49-97d9-4005-a53e-83fcc8f2a2ce",[192],[1734,1742],{"id":18,"sortIndex":19,"affiliation":1735,"properties":18},{"id":1736,"createTime":1737,"updateTime":1737,"relativeEntities":1738,"slug":18,"properties":1739,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"f57512a8-5659-4ffc-a5c3-48d489f4d2c2","2024-01-27T03:51:44.215+00:00",[],{"title":1740},{"VI":1741},"Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, China",{"id":1743,"sortIndex":222,"affiliation":1744,"properties":1751},"8beb7976-7d0d-4a86-ad23-3422abf5acb1",{"id":1745,"createTime":1746,"updateTime":1746,"relativeEntities":1747,"slug":18,"properties":1748,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"0ef07ceb-1f83-439e-b03c-cd3667148043","2024-01-18T03:54:15.040+00:00",[],{"title":1749},{"VI":1750},"Research and Development Center for Tissue Engineering, College of Stomatology, Fourth Military Medical University, Xi’an, Shaanxi, China",{},{"title":1753},{"VI":1754},"Yan Jin",{"id":1756,"sortIndex":19,"researcher":18,"roles":1757,"affiliations":1758,"properties":1764},"e80623da-8a1d-4566-a380-6e8ff4a505af",[192],[1759],{"id":18,"sortIndex":19,"affiliation":1760,"properties":18},{"id":1736,"createTime":1737,"updateTime":1737,"relativeEntities":1761,"slug":18,"properties":1762,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1763},{"VI":1741},{"title":1765},{"VI":1766},"Huanjing Bi",{"url":1728,"publisher":1768,"properties":1795},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1769,"slug":10,"properties":1770,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1773,"manageAffiliations":1774,"indexDatabases":1775,"url":18,"thumbnailPath":18,"statistic":1790,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1771,"title":1772},{"VOID":13},{"EN":15},[],[],[1776,1783],{"id":94,"indexDatabase":1777,"url":107,"indexYears":108,"academicFieldIds":1782,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":1778,"label":1779,"description":1780,"key":104,"publicationTags":1781,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":1784,"url":18,"indexYears":18,"academicFieldIds":1789,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":1785,"label":1786,"description":1787,"key":128,"publicationTags":1788,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":1791,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":1792,"totalCitation":151,"totalCitationByYear":1793,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":1794,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":1796,"pages":1797},{"VOID":421},{"VOID":1798},"63-72","2013-09-18",{"id":1801,"createTime":1802,"updateTime":1803,"relativeEntities":1804,"slug":1805,"properties":1806,"entityType":183,"verifyStatus":184,"verifyTime":1803,"verifyNote":185,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1815,"fullTextUrl":18,"authors":1816,"publicationType":273,"publisherRelationship":1868,"citationCount":18,"citationInfo":18,"publishDate":1901,"publishYear":1902,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":309},"924012b4-a9c3-4bcb-a6e2-e6cc829a530b","2024-02-14T05:12:43.305+00:00","2025-02-02T22:47:42.909+00:00",[],"Current-understanding-of-tyrosine-kinase-BMX-in-inflammation-and-its-inhibitors",{"references":1807,"abstract":1809,"title":1811,"doi":1813},{"VOID":1808},"Horwood NJ, Urbaniak AM, Danks L. Tec family kinases in inflammation and disease. Int Rev Immunol 2012;31:87–103.\nFaris M, Bot A. In this issue: Tec kinases in the crosshairs. Int Rev Immunol 2012;31:85–6.\nBlock H, Zarbock A. The role of the tec kinase Bruton’s tyrosine kinase (Btk) in leukocyte recruitment. Int Rev Immunol 2012;31:104–18.\nEkman N, Lymboussaki A, Vastrik I, Sarvas K, Kaipainen A, Alitalo K. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. Circulation 1997;96:1729–32.\nKaukonen J, Lahtinen I, Laine S, Alitalo K, Palotie A. BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias. Br J Haematol 1996;94:455–60.\nWeil D, Power MA, Smith SI, Li CL. Predominant expression of murine Bmx tyrosine kinase in the granulo-monocytic lineage. Blood 1997;90:4332–40.\nGottar-Guillier M, Dodeller F, Huesken D, Iourgenko V, Mickanin C, Labow M, et al. The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. J Immunol 2011;186:6014–23.\nBoucheron N, Ellmeier W. The role of Tec family kinases in the regulation of T-helper-cell differentiation. Int Rev Immunol 2012;31:133–54.\nAugust A, Ragin MJ. Regulation of T-cell responses and disease by tec kinase Itk. Int Rev Immunol 2012;31:155–65.\nBuggy JJ, Elias L. Bruton tyrosine kinase (BTK) and its role in B-cell malignancy. Int Rev Immunol 2012;31:119–32.\nCenni B, Gutmann S, Gottar-Guillier M. BMX and its role in inflammation, cardiovascular disease, and cancer. Int Rev Immunol 2012;31:166–73.\nTamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, et al. BMX, a novel nonreceptor tyrosine kinase gene of the BTK\u002FITK\u002FTEC\u002FTXK family located in chromosome Xp22.2. Oncogene 1994;9:3683–8.\nBarton GM. A calculated response: Control of inflammation by the innate immune system. J Clin Invest 2008;118:413–20.\nFry DE. Sepsis, systemic inflammatory response, and multiple organ dysfunction: The mystery continues. Am Surg 2012;78:1–8.\nChen XL, Xia ZF, Wei D, Han S, Ben DF, Wang GQ. Role of p38 mitogen-activated protein kinase in Kupffer cell secretion of the proinflammatory cytokines after burn trauma. Burns 2003;29:533–9.\nChen XL, Sun L, Guo F, Wang F, Liu S, Liang X, et al. High-mobility group box-1 induces proinflammatory cytokines production of Kupffer cells through TLRs-dependent signaling pathway after burn injury. PLoS One 2012;7:e50668.\nNakagome K, Matsushita S, Nagata M. Neutrophilic inflammation in severe asthma. Int Arch Allergy Immunol 2012;158 Suppl 1:96–102.\nAllen TC, Kurdowska A. Interleukin 8 and acute lung injury. Arch Pathol Lab Med 2014;138:266–9.\nPichert A, Schlorke D, Franz S, Arnhold J. Functional aspects of the interaction between interleukin-8 and sulfated glycosaminoglycans. Biomatter 2012;2:142–8.\nPalmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM. Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts. Biochem Biophys Res Commun 2008;370:599–602.\nPalmer CD, Mutch BE, Workman S, McDaid JP, Horwood NJ, Foxwell BM. Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkappB activity. Blood 2008;111:1781–8.\nSemaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J. Etk\u002FBMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. J Immunol 2008;180:3485–91.\nChen KY, Wu CC, Chang CF, Chen YH, Chiu WT, Lou YH, et al. Suppression of Etk\u002FBmx protects against ischemic brain injury. Cell Transplant 2012;21:345–54.\nLu YC, Yeh WC, Ohashi PS. LPS\u002FTLR4 signal transduction pathway. Cytokine 2008;42:145–51.\nChen XL, Xia ZF, Ben DF, Wang GQ, Wei D. Role of p38 mitogen-activated protein kinase in lung injury after burn trauma. Shock 2003;19:475–9.\nMogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009;22:240–73.\nYang QW, Mou L, Lv FL, Zhu PF, Wang ZG, Jiang JX, et al. Novel TLR4-antagonizing peptides inhibit LPS-induced release of inflammatory mediators by monocytes. Biochem Biophys Res Commun 2005;329:846–54.\nLiang X, Wang RS, Wang F, Liu S, Guo F, Sun L, et al. Sodium butyrate protects against severe burn-induced remote acute lung injury in rats. PLoS One 2013;8:e68786.\nGuo L, Guo Y, Xiao S. Expression of tyrosine kinase Etk\u002FBmx and its relationship with AP-1- and NF-kappa B-associated proteins in hepatocellular carcinoma. Oncology 2007;72:410–6.\nSaharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O. The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. Blood 1997;90:4341–53.\nTsai YT, Su YH, Fang SS, Huang TN, Qiu Y, Jou YS, et al. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol Cell Biol 2000;20:2043–54.\nGuryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, et al. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 2011;19:498–511.\nJarboe JS, Dutta S, Velu SE, Willey CD. Mini-review: Bmx kinase inhibitors for cancer therapy. Recent Pat Anticancer Drug Discov 2013;8:228–38.\nLiu F, Zhang X, Weisberg E, Chen S, Hur W, Wu H, et al. Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem Biol 2013;8:1423–8.\nBurger JA, Buggy JJ. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765). Leuk Lymphoma 2013;54:2385–91.\nChang BY, Huang MM, Francesco M, Chen J, Sokolove J, Magadala P, et al. The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells. Arthritis Res Ther 2011;13:R115.\nAdvani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed\u002Frefractory B-cell malignancies. J Clin Oncol 2013;31: 88–94.",{"EN":1810},"Tec family kinases, which include tyrosine kinase expressed in hepatocellular carcinoma (TEC), Bruton’s tyrosine kinase (BTK), interleukin (IL)-2-inducible T-cell kinase (ITK), tyrosine-protein kinase (TXK), and bone marrow tyrosine kinase on chromosome X (BMX), are the second largest group of non-receptor tyrosine kinases and have a highly conserved carboxyl-terminal kinase domain. BMX was identified in human bone marrow cells, and was demonstrated to have been expressed in myeloid hematopoietic lineages cells, endothelial cells, and several types of cancers. Significant progress in this area during the last decade revealed an important role for BMX in inflammation and oncologic disorders. This review focuses on BMX biology, its role in inflammation and possible signaling pathways, and the potential of selective BMX inhibitors.",{"EN":1812},"Current understanding of tyrosine kinase BMX in inflammation and its inhibitors",{"VOID":1814},"10.4103\u002F2321-3868.135483","https:\u002F\u002Facademic.oup.com\u002Fburnstrauma\u002Farticle\u002F2\u002F3\u002F2321-3868.135483\u002F5650510",[1817,1832,1844,1856],{"id":1818,"sortIndex":19,"researcher":18,"roles":1819,"affiliations":1820,"properties":1829},"d54fb4cd-d77b-40fb-a72c-85d03628e167",[192],[1821],{"id":18,"sortIndex":19,"affiliation":1822,"properties":18},{"id":1823,"createTime":1824,"updateTime":1824,"relativeEntities":1825,"slug":18,"properties":1826,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"8772c626-0cc3-4c3e-b12b-c4202216b0ae","2024-02-14T05:12:43.319+00:00",[],{"title":1827},{"VI":1828},"Department of Burns, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China",{"title":1830},{"VI":1831},"Le Qiu",{"id":1833,"sortIndex":144,"researcher":18,"roles":1834,"affiliations":1835,"properties":1841},"2c974327-d518-4632-828a-edd335f356c3",[192],[1836],{"id":18,"sortIndex":19,"affiliation":1837,"properties":18},{"id":1823,"createTime":1824,"updateTime":1824,"relativeEntities":1838,"slug":18,"properties":1839,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1840},{"VI":1828},{"title":1842},{"VI":1843},"Xu-Lin Chen",{"id":1845,"sortIndex":222,"researcher":18,"roles":1846,"affiliations":1847,"properties":1853},"f6ac8cf2-e127-488a-a929-ea5893597f6c",[192],[1848],{"id":18,"sortIndex":19,"affiliation":1849,"properties":18},{"id":1823,"createTime":1824,"updateTime":1824,"relativeEntities":1850,"slug":18,"properties":1851,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1852},{"VI":1828},{"title":1854},{"VI":1855},"Fei Wang",{"id":1857,"sortIndex":262,"researcher":18,"roles":1858,"affiliations":1859,"properties":1865},"a7f8e391-060f-4989-a13d-3f7b24cc2222",[192],[1860],{"id":18,"sortIndex":19,"affiliation":1861,"properties":18},{"id":1823,"createTime":1824,"updateTime":1824,"relativeEntities":1862,"slug":18,"properties":1863,"entityType":79,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1864},{"VI":1828},{"title":1866},{"VI":1867},"Sheng Liu",{"url":1815,"publisher":1869,"properties":1896},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1870,"slug":10,"properties":1871,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1874,"manageAffiliations":1875,"indexDatabases":1876,"url":18,"thumbnailPath":18,"statistic":1891,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"eissn":1872,"title":1873},{"VOID":13},{"EN":15},[],[],[1877,1884],{"id":94,"indexDatabase":1878,"url":107,"indexYears":108,"academicFieldIds":1883,"indexDatabaseRanking":18},{"id":96,"createTime":97,"updateTime":98,"relativeEntities":1879,"label":1880,"description":1881,"key":104,"publicationTags":1882,"standard":18},[],{"EN":101,"VI":101},{"EN":101,"VI":103},[106],[110,111,112,113,114,115],{"id":117,"indexDatabase":1885,"url":18,"indexYears":18,"academicFieldIds":1890,"indexDatabaseRanking":18},{"id":119,"createTime":120,"updateTime":121,"relativeEntities":1886,"label":1887,"description":1888,"key":128,"publicationTags":1889,"standard":18},[],{"EN":124,"VI":124},{"VI":126,"EN":127},[130,131],[133,134,135],{"impactFactor":19,"impactFactorByYear":1892,"i10Index":143,"i10IndexLast5Year":144,"totalPublication":145,"totalPublicationByYear":1893,"totalCitation":151,"totalCitationByYear":1894,"totalCitationPerPublication":157,"totalCitationPerPublicationByYear":1895,"hindexLast5Year":143,"hindex":143},{"2017":138,"2018":139,"2019":140,"2020":141,"2021":142},{"2013":143,"2014":147,"2015":147,"2016":148,"2017":148,"2018":149,"2019":150},{"2015":144,"2016":153,"2017":154,"2018":155,"2019":156},{"2015":159,"2016":160,"2017":161,"2018":162,"2019":163},{"volume":1897,"pages":1899},{"VOID":1898},"2",{"VOID":1900},"121-124","2014-07-28",2014]