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and irrigation regimens in reducing the bacterial population within root canals, J Endod, 28, 181, 10.1097\u002F00004770-200203000-00009\nHeling, 1992, Efficacy of a sustained release device containing chlorhexidine and Ca(OH)2 in preventing secondary infection of dentinal tubules, Int Endod J, 25, 20, 10.1111\u002Fj.1365-2591.1992.tb00944.x\nLeonardo, 1999, In vivo antimicrobial activity of 2% chlorhexidine used as a root canal irrigating solution, J Endod, 25, 167, 10.1016\u002FS0099-2399(99)80135-6\nKomorowsky, 2000, Antimicrobial substantivity of chlorhexidine-treated bovine root dentin, J Endod, 26, 315, 10.1097\u002F00004770-200006000-00001\nYamashita, 2003, Scanning electron microscopic study of the cleaning ability of chlorhexidine as a root canal irrigant, Int Endod J, 36, 391, 10.1046\u002Fj.1365-2591.2003.00656.x\nNelson-Filho, 2002, Radiographic evaluation of the effect of endotoxin (LPS) plus calcium hydroxide on apical and periapical tissues of dogs, J Endod, 28, 694, 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Candida species in irradiated, dentate, xerostomic, nasopharyngeal carcinoma survivors, J Clin Microbiol, 38, 2219, 10.1128\u002FJCM.38.6.2219-2226.2000\nBelazi, 2004, Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer: prevalence, azole susceptibility profiles and response to antifungal treatment, Oral Microbiol Immunol, 19, 347, 10.1111\u002Fj.1399-302x.2004.00165.x\nRedding, 2004, Candida glabrata is an emerging cause of oropharyngeal candidiasis in patients receiving radiation for head and neck cancer, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 97, 47, 10.1016\u002Fj.tripleo.2003.09.008\nBonan, 2003, Evaluation of salivary flow in patients during head and neck radiotherapy, Braz Oral Res, 17, 156\nSilverman, 1984, Occurrence of oral Candida in irradiated head and neck cancer patients, J Oral Med, 39, 194\nAl-Abeid, 2004, Isolation and characterization of Candida spp. in Jordanian cancer patients: prevalence, pathogenic determinants, and antifungal sensitivity, Jpn J Infect Dis, 57, 279\nMucke, 1998, Fluconazole prophylaxis in patients with head and neck tumours undergoing radiation and radiochemotherapy, Mycoses, 41, 421, 10.1111\u002Fj.1439-0507.1998.tb00364.x\nRedding, 2001, Candida dubliniensis in radiation-induced oropharyngeal candidiasis, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 91, 659, 10.1067\u002Fmoe.2001.112946\nDahiya, 2003, Oropharyngeal candidiasis caused by non-albicans yeast in patients receiving external beam radiotherapy for head-and-neck cancer, Int J Radiat Oncol Biol Phys, 57, 79, 10.1016\u002FS0360-3016(03)00415-2\nSandven, 2000, Epidemiology of candidemia, Rev Iberoam Micol, 17, 73\nGodoy, 2003, Species distribution and antifungal susceptibility profile of Candida spp. bloodstream isolates from Latin American hospitals, Mem Inst Oswaldo Cruz, 98, 401, 10.1590\u002FS0074-02762003000300020\nColombo, 2003, Global distribution and outcomes for Candida species causing invasive candidiasis: 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muscle: an operation for correction, Br J Plast Surg, 2, 78\nPark, 2008, Importance of the chin in lower facial contour: narrowing genioplasty to achieve a feminine and slim lower face, Plast Reconstr Surg, 122, 261, 10.1097\u002FPRS.0b013e3181774179\nSatoh, 2004, Mandibular contouring surgery by angular contouring combined with genioplasty in Orientals, Plast Reconstr Surg, 113, 425, 10.1097\u002F01.PRS.0000097501.30772.48\nConverse, 1977, Deformities of the jaws, 1406\nGui, 2005, Intraoral one-stage curved osteotomy for the prominent mandibular angle: a clinical study of 407 cases, Aesth Plast Surg, 29, 552, 10.1007\u002Fs00266-004-0149-7\nBaek, 1989, The prominent mandibular angle: preoperative management, operative technique and results in 42 patients, Plast Reconstr Surg, 83, 272, 10.1097\u002F00006534-198902000-00012\nBaek, 1994, Refinement in aesthetic contouring of the prominent mandibular angle, Aesth Plast Surg, 18, 283, 10.1007\u002FBF00449796\nKim, 2003, Resection of the 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radiographs: a receiver operating characteristic analysis, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 103, 694, 10.1016\u002Fj.tripleo.2006.04.005\nLevander, 1998, Early radiographic diagnosis of apical root resorption during orthodontic treatment: a study of maxillary incisors, Eur J Orthod, 20, 57, 10.1093\u002Fejo\u002F20.1.57\nKravitz, 1992, Assessment of external root resorption using digital subtraction radiography, J Endod, 18, 275, 10.1016\u002FS0099-2399(06)80954-4\nHintze, 1992, Digital subtraction radiography for assessment of simulated root resorption cavities, Endod Dent Traumatol, 8, 149, 10.1111\u002Fj.1600-9657.1992.tb00234.x\nObuchowski, 2003, Receiver operating characteristic curves and their use in radiology, Radiology, 229, 3, 10.1148\u002Fradiol.2291010898\nMetz, 1989, Some practical issues of experimental design and data analysis in radiological ROC studies, Invest Radiol, 24, 234, 10.1097\u002F00004424-198903000-00012\nGoldberg, 1998, Radiographic 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failure, Int Endod J, 34, 399, 10.1046\u002Fj.1365-2591.2001.00437.x\nBarthel, 1997, TNF-α release in monocytes after exposure to calcium hydroxide treated Escherichia coli LPS, Int Endod J, 30, 155, 10.1111\u002Fj.1365-2591.1997.tb00690.x\nPitts, 1982, Investigation of the role of endotoxin in periapical inflammation, J Endod, 8, 10, 10.1016\u002FS0099-2399(82)80310-5\nYamasaki, 1992, Endotoxin and gram-negative bacteria in the rat periapical lesions, J Endod, 18, 501, 10.1016\u002FS0099-2399(06)81351-8\nMurakami, 2001, A possible mechanism of maxillofacial abscess formation: involvement of Porphyromonas endodontalis lipopolusaccharide via the expression of inflammatory cytokines, Oral Microbiol Immunol, 16, 321, 10.1034\u002Fj.1399-302X.2001.160601.x\nHong, 2004, The role of lipopolysaccharide infections in bone resorption of periapical lesion, J Oral Pathol Med, 33, 162, 10.1111\u002Fj.0904-2512.2004.00045.x\nHoriba, 1990, A study of the distribution of endotoxin in the dentinal wall of infected root canals, J Endod, 16, 331, 10.1016\u002FS0099-2399(06)81944-8\nPetsch, 2000, Endotoxin removal from protein solutions, J Biotechnol, 76, 97, 10.1016\u002FS0168-1656(99)00185-6\nWang, 1993, The role of interleukin-1α in the pathogenesis of periapical bone destruction in a rat model system, Oral Microbiol Immunol, 8, 50, 10.1111\u002Fj.1399-302X.1993.tb00543.x\nGarduño, 1995, Efectos del agua ozonificada en la placa dentobacteriana, Assoc Dent Med, 52, 305\nRodriguez, 1994, Efectos del ozono en el tratamiento de la gingivoestomatitis herpética aguda, Rev Cubana Estomatol, 31, 14\nOizumi, 1998, In vitro testing of a denture cleaning method using ozone, J Med Dent Sci, 45, 135\nVelano, 2001, Avaliação in vitro da atividade antibacteriana da água ozonizada frente ao Staphylococcus aureus, Pesq Odontol Bras, 15, 18, 10.1590\u002FS1517-74912001000100004\nNagayoshi, 2004, Antimicrobial effect of ozonated water on bacteria invading dentinal tubules, J Endod, 30, 240, 10.1097\u002F00004770-200411000-00007\nEstrela, 2007, Antimicrobial efficacy of ozonated water, gaseous ozone, sodium hypochlorite and chlorhexidine in infected human root canals, Int Endod J, 40, 85, 10.1111\u002Fj.1365-2591.2006.01185.x\nMenezes, 2004, In vitro evaluation of the effectiveness of irrigants and intracanal medicaments on microorganisms within root canals, Int Endod J, 37, 311, 10.1111\u002Fj.0143-2885.2004.00799.x\nOliveira, 2005, Diffusion ability of endotoxin through dentinal tubules, Oral Res, 19, 5\nParaskeva, 1998, Influence of ozonation conditions on the treatability of secondary effluents, Ozone Sci Engineering, 20, 133, 10.1080\u002F01919519808547282\nGüzel-seydim, 2004, Use of ozone in the food industry, Lebensm Wiss Technol, 37, 453, 10.1016\u002Fj.lwt.2003.10.014\nGuerra, 1997, Aplicación de la ozonoterapia en el tratamiento de la alveolitis, Rev Cubana Estomatol, 34, 21\nBaysan, 2000, Antimicrobial effect of a novel ozone-generating device on microorganisms associated with primary root carious lesions in vitro, Caries Res, 34, 498, 10.1159\u002F000016630\nSiqueira, 2004, Fungi in endodontic infections, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 97, 632, 10.1016\u002Fj.tripleo.2003.12.022\nFaria, 2005, Effects of ozonated water on Candida albicans oral isolates, Braz J Oral Sci, 4, 783\nKomanapalli, 1998, Inactivation of bacteriophage lambda, Escherichia coli, and Candida albicans by ozone, Appl Microbiol Biotechnol, 49, 766, 10.1007\u002Fs002530051244\nHems, 2005, An in vitro evaluation of the ability of ozone to kill a strain of Enterococcus faecalis, Int Endod J, 38, 22, 10.1111\u002Fj.1365-2591.2004.00891.x\nHaas, 2003, Effect of initial microbial density on inactivation of Giardia muris by ozone, Water Res, 37, 2980, 10.1016\u002FS0043-1354(03)00112-X\nDiao, 2004, Electron microscopic investigation of the bactericidal action of electrochemical disinfection in comparison with chlorination, ozonation and Fenton reaction, Process 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1970, Bilateral macrodontism of mandibular third molars with impaction of second molars, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 29, 717, 10.1016\u002F0030-4220(70)90269-0\nGraubard, 1977, Fusion of a lower second and third molar and macrodontia of a lower first molar, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 44, 817, 10.1016\u002F0030-4220(77)90394-2\nReichart, 1977, Macrodontia of a mandibular premolar, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 44, 606, 10.1016\u002F0030-4220(77)90305-X\nGroper, 1987, Macrodontia of a single tooth: review of literature and report of case, J Am Dent Assoc, 114, 69, 10.14219\u002Fjada.archive.1987.0044\nGazit, 1991, Macrodontia of maxillary central incisors: case report, Quintessence Int, 22, 883\nDuckmanton, 1995, Maxillary permanent central incisor with abnormal crown size and dens invagiantus: case report, Endod Dent Traumatol, 11, 150, 10.1111\u002Fj.1600-9657.1995.tb00477.x\nHolmes, 1976, Premature eruption and macrodontia associated with insulin resistant diabetes and pineal hyperplasia, Br Dent J, 141, 280, 10.1038\u002Fsj.bdj.4803837\nJorgenson, 1975, Otodental dysplasia, Birth Defects, 11, 115\nVan Doorne, 1998, Otodental syndrome, Int J Oral Maxillofac Surg, 27, 121, 10.1016\u002FS0901-5027(98)80309-3\nRowe, 1962, Hemifacial hypertrophy: Review of the literature and addition of four cases, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 15, 572, 10.1016\u002F0030-4220(62)90177-9\nMacMillan, 1990, Regional macrodontia and regional bony enlargement associated with congenital infiltrating lipomatosis of the face presenting as unilateral facial hyperplasia, Int J Oral Maxillofac Surg, 19, 283, 10.1016\u002FS0901-5027(05)80421-7\nAlvesalo, 1975, The 47,XYY male, Y chromosome, and tooth size, Am J Hum Genet, 27, 53\nHermann, 1975, The KBG syndrome—a syndrome of short stature, characteristic facies, mental retardation, macrodontia and skeletal anomalies, Birth Defects, 11, 7\nEkman-Westborg, 1974, Multiple anomalies in dental morphology: macrodontia, multituberculism, central cusps and pulpal invaginations, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 38, 217, 10.1016\u002F0030-4220(74)90059-0\nReichart, 1978, Polyanomalodontia, J Oral Path, 7, 100, 10.1111\u002Fj.1600-0714.1978.tb01584.x\nMiikada, 1995\nRitzau, 1997, The Ekman-Westborg–Julin syndrome, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 84, 293, 10.1016\u002FS1079-2104(97)90346-2\nNakagawa, 1997, Ekman-Westborg–Julin syndrome, Int J Oral Maxillofac Surg, 26, 49, 10.1016\u002FS0901-5027(97)80847-8\nBenjamin, 2003, Multiple macrodontic tuberculism, Am J Med Genet, 120A, 283, 10.1002\u002Fajmg.a.20102\nMann, 1990, Anomalous morphologic formation of deciduous and permanent teeth in a 5-year-old 15th century child: a variant of the Ekman-Westborg–Julin syndrome, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 70, 90, 10.1016\u002F0030-4220(90)90185-U\nYoda, 1998, Multiple macrodonts with odontoma in a mother and son— a variant of Ekman-Westborg–Julin syndrome, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 85, 301, 10.1016\u002FS1079-2104(98)90012-9\nAsh, 1993, 58\nShafer, 1983, 35\nReichart, 1982, Morphologic findings in dens invaginatus, Int J Oral Surg, 11, 59, 10.1016\u002FS0300-9785(82)80050-1\nOehlers, 1957, Dens invaginatus (dilated compound odontome) 1, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 10, 1204, 10.1016\u002F0030-4220(57)90077-4",{"EN":912},"The Ekman-Westborg and Julin trait: report of a 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2008, Mandatory second opinion in surgical pathology referral material: clinical consequences of major disagreements, Am J Surg Pathol, 32, 732, 10.1097\u002FPAS.0b013e31815a04f5\nLueck, 2009, Mandatory second opinion in cytopathology, Cancer Cytopathol, 117, 82, 10.1002\u002Fcncy.20019\nCoblentz, 2001, Impact of second opinion pathology in the definitive management of patients with bladder carcinoma, Cancer, 91, 1284, 10.1002\u002F1097-0142(20010401)91:7\u003C1284::AID-CNCR1130>3.0.CO;2-E\nKronz, 1999, Mandatory second opinion surgical pathology at a large referral hospital, Cancer, 86, 2426, 10.1002\u002F(SICI)1097-0142(19991201)86:11\u003C2426::AID-CNCR34>3.0.CO;2-3\nKronz, 2005, The role of second opinion pathology in the management of lesions of the head and neck, Curr Opin Otolaryngol Head Neck Surg, 13, 81, 10.1097\u002F01.moo.0000156162.20789.66\nWestra, 2002, The impact of second opinion surgical pathology on the practice of head and neck surgery: a decade experience at a large referral hospital, Head Neck, 24, 684, 10.1002\u002Fhed.10105\nChafe, 2000, An analysis of the impact of pathology review in gynecologic cancer, Int J Radiat Oncol Biol Phys, 48, 1433, 10.1016\u002FS0360-3016(00)00791-4\nHahm, 2001, The value of second opinion in gastrointestinal and liver pathology, Arch Pathol Lab Med, 125, 736, 10.5858\u002F2001-125-0736-TVOSOI\nHamady, 2005, Surgical pathological second opinion in thyroid malignancy: impact on patients' management and prognosis, Eur J Surg Oncol, 31, 74, 10.1016\u002Fj.ejso.2004.08.010\nStaradub, 2002, Changes in breast cancer therapy because of pathology second opinions, Ann Surg Oncol, 9, 982, 10.1007\u002FBF02574516\nWurzer, 1998, Histopathologic review of prostate biopsies from patients referred to a comprehensive cancer center: correlation of pathologic findings, analysis of cost, and impact on treatment, Cancer, 83, 753, 10.1002\u002F(SICI)1097-0142(19980815)83:4\u003C753::AID-CNCR18>3.0.CO;2-R\nCook, 2001, Referrals 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