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Different answers from comparative and artificial selection approaches, Behav Genet, 42, 830, 10.1007\u002Fs10519-012-9543-0\nChandra, 1981, Concentrations of striatal catecholamines in rats given manganese chloride through drinking water, J Neurochem, 36, 683, 10.1111\u002Fj.1471-4159.1981.tb01642.x\nChandra, 1979, Effect of stress on the response of rat brain to manganese, Toxicol Appl Pharmacol, 47, 603, 10.1016\u002F0041-008X(79)90530-1\nChandra, 1979, Manganese-induced behavioral dysfunction and its neurochemical mechanism in growing mice, J Neurochem, 33, 1217, 10.1111\u002Fj.1471-4159.1979.tb05267.x\nCotzias, 1974, Manganese and catecholamines, Adv Neurol, 5, 235\nCotzias, 1958, Manganese in health and disease, Physiol Rev, 38, 503, 10.1152\u002Fphysrev.1958.38.3.503\nCrossgrove, 2004, Manganese toxicity upon overexposure, NMR Biomed, 17, 544, 10.1002\u002Fnbm.931\nDobson, 2004, Manganese neurotoxicity, Ann NY Acad Sci, 1012, 115, 10.1196\u002Fannals.1306.009\nDodd, 2013, Consequences of manganese administration for striatal dopamaine and motor behavior in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposed C57BL\u002F6 mice, Hum Exp Toxicol, 32, 865, 10.1177\u002F0960327112469043\nFaul, 2007, G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences, Behav Res Methods, 39, 175, 10.3758\u002FBF03193146\nFitsanakis, 2008, Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging, Toxicol Sci, 103, 116, 10.1093\u002Ftoxsci\u002Fkfn019\nGianutsos, 1982, Alterations in brain dopamine and GABA following inorganic or organic manganese administration, Neurotoxicology, 3, 75\nGuilarte, 2010, Manganese and Parkinson's disease: a critical review and new findings, Environ Health Perspect, 118, 1071, 10.1289\u002Fehp.0901748\nGuilarte, 2006, Nigrostriatal dopamine system dysfunction and subtle motor 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10.1016\u002Fj.neuro.2008.11.001\nChoong, 2011, Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P A53T and E46K, Neurotoxicology, 32, 857, 10.1016\u002Fj.neuro.2011.05.012\nCosta, 2007, Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants, Neurotoxicology, 28, 1047, 10.1016\u002Fj.neuro.2007.08.007\nCosta, 2011, Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?, Neurotoxicology, 32, 9, 10.1016\u002Fj.neuro.2010.12.010\nde Groot, 2013, Don’t judge a neuron only by its cover: neuronal function in in vitro developmental neurotoxicity testing, Toxicol Sci, 132, 1, 10.1093\u002Ftoxsci\u002Fkfs269\nDingemans, 2009, Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells, Toxicol Sci, 107, 490, 10.1093\u002Ftoxsci\u002Fkfn249\nDingemans, 2011, Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system, Environ Health Perspect, 119, 900, 10.1289\u002Fehp.1003035\nDuman, 2008, Calcium transport mechanisms of PC12 cells, J Gen Physiol, 131, 307, 10.1085\u002Fjgp.200709915\nFox, 2010, Gene-chemical interactions in the developing mammalian nervous system: effects on proliferation, neurogenesis and differentiation, Neurotoxicology, 31, 589, 10.1016\u002Fj.neuro.2010.03.007\nGreene, 1976, Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor, Proc Natl Acad Sci USA, 73, 2424, 10.1073\u002Fpnas.73.7.2424\nHissink, 2007, Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents III. 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ryanodine receptor-Ca2+ channel complex type 1 (RyR1), Chem Res Toxicol, 19, 92, 10.1021\u002Ftx050196m\nPöltl, 2012, Uncoupling of ATP-depletion and cell death in human dopaminergic neurons, Neurotoxicology, 33, 769, 10.1016\u002Fj.neuro.2011.12.007\nPothos, 1996, L-3,4-dihydroxyphenylalanine increases the quantal size of exocytotic dopamine release in vitro, J Neurochem, 66, 629, 10.1046\u002Fj.1471-4159.1996.66020629.x\nRadio, 2008, Developmental neurotoxicity testing in vitro: models for assessing chemical effects on neurite outgrowth, Neurotoxicology, 29, 361, 10.1016\u002Fj.neuro.2008.02.011\nShafer, 1991, Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies, Neurotoxicology, 12, 473\nSong, 2011, Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration, Neurotoxicology, 32, 586, 10.1016\u002Fj.neuro.2011.05.018\nSong, 1998, Alterations of cytoskeletal tau protein of SH-SY5Y human neuroblastoma cells after exposure to MPTP, Neurotoxicology, 19, 73\nStenberg, 2011, Multivariate toxicity profiles and QSAR modeling of non-dioxin-like PCBs – an investigation of in vitro screening data from ultra-pure congeners, Chemosphere, 85, 1423, 10.1016\u002Fj.chemosphere.2011.08.019\nTilson, 1998, The neurotoxicity of polychlorinated biphenyls, Neurotoxicology, 19, 517\nTimchalk, 2008, Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat, Neurotoxicology, 29, 428, 10.1016\u002Fj.neuro.2008.02.004\nTischler, 1983, Glucocorticoids increase catecholamine synthesis and storage in PC12 phaeochromocytoma cell cultures, J Neurochem, 40, 364, 10.1111\u002Fj.1471-4159.1983.tb11291.x\nvan Thriel, 2012, Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts, Neurotoxicology, 33, 911, 10.1016\u002Fj.neuro.2011.10.002\nVerner, 2010, Alteration of infant attention and activity by polychlorinated biphenyls: unravelling critical windows of susceptibility using physiologically based pharmacokinetic modeling, Neurotoxicology, 31, 424, 10.1016\u002Fj.neuro.2010.05.011\nVinken, 2013, The adverse outcome pathway concept: a pragmatic tool in toxicology, Toxicology, 312C, 158, 10.1016\u002Fj.tox.2013.08.011\nWatanabe, 2011, Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study, Environ Toxicol Chem, 30, 9, 10.1002\u002Fetc.373\nWesterink, 2008, The PC12 cell as model for neurosecretion, Acta Physiol (Oxf), 192, 273, 10.1111\u002Fj.1748-1716.2007.01805.x\nWesterink, 2004, Exocytosis: using amperometry to study presynaptic mechanisms of neurotoxicity, Neurotoxicology, 25, 461, 10.1016\u002Fj.neuro.2003.10.006\nWigestrand, 2013, Non-dioxin-like PCBs inhibit [3H]WIN-35,428 binding to the 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Bull., 140, 34, 10.1016\u002Fj.brainresbull.2018.03.016\nAlmeida, 2005, Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses, Neurobiol. Dis., 20, 187, 10.1016\u002Fj.nbd.2005.02.008\nAminyavari, 2019, Protective role of Apelin-13 on amyloid β25–35-induced memory deficit; Involvement of autophagy and apoptosis process, Prog. Neuropsychopharmacol. Biol. Psychiatry, 89, 322, 10.1016\u002Fj.pnpbp.2018.10.005\nArancibia, 2008, Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats, Neurobiol. Dis., 31, 316, 10.1016\u002Fj.nbd.2008.05.012\nAskri, 2018, Intranasal instillation of iron oxide nanoparticles induces inflammation and perturbation of trace elements and neurotransmitters, but not behavioral impairment in rats, Environ. Sci. Pollut. Res. - Int., 25, 16922, 10.1007\u002Fs11356-018-1854-0\nAzimi, 2016, Protective effects of salicylate on PKA inhibitor (H-89)-induced spatial memory deficit via lessening autophagy and apoptosis in rats, Pharmacol. Biochem. Behav., 150, 158, 10.1016\u002Fj.pbb.2016.10.008\nBai, 1998, The mtDNA‐encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme, EMBO J., 17, 4848, 10.1093\u002Femboj\u002F17.16.4848\nBarco, 2005, Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture, Neuron, 48, 123, 10.1016\u002Fj.neuron.2005.09.005\nBeckmann, 2011, Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer’s disease: application to passive Aβ immunotherapy, J. 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