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The role of poly (ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice. Molecular Immunology, 63(2), 394–405.\nAhmad, S. F., Zoheir, K. M., Ansari, M. A., Nadeem, A., Bakheet, S. A., Al-Ayadhi, L. Y., et al. (2017d). Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism. Molecular Neurobiology, 54(6), 4390–4400.\nAhmad, S. F., Zoheir, K. M., Ansari, M. A., Nadeem, A., Bakheet, S. A., et al. (2015b). Histamine 4 receptor promotes expression of costimulatory B7.1\u002FB7.2 molecules, CD28 signaling and cytokine production in stress-induced immune responses. Journal of Neuroimmunology, 289, 30–42.\nAl-Ayadhi, L. Y., & Mostafa, G. A. (2013). Elevated serum levels of macrophage-derived chemokine and thymus and activation-regulated chemokine in autistic children. Journal of Neuroinflammation, 10, 72.\nAnsari, M. A., Attia, S. M., Nadeem, A., Bakheet, S. A., Raish, M., Khan, T. H., et al. (2017a). 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L., & Rivest, S. (2002). The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathology, 12(3), 308–319.\nZhou, X. M., Zhou, M. L., Zhang, X. S., et al. (2014). Resveratrol prevents neuronal apoptosis in an early brain injury model. Journal of Surgical Research, 189, 159–165.",{"EN":131},"Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments in communication, repetitive and social interaction, restricted, and stereotyped patterns of behavior. Resveratrol has been extensively studied pharmacologically and biologically and has anti-inflammatory, antioxidant, and neuroprotective effects on neuronal damage in neurodegenerative disorders. The BTBR T+ Itpr3tf\u002FJ (BTBR) autistic mouse model has been explored for treatment of autism, which shows low reciprocal social interactions, impaired juvenile play, and decreased social approach. Here, we explored whether resveratrol treatment decreases neuroimmune dysregulation mediated through toll-like receptor (TLR4) and nuclear factor-κB (NF-κB) signaling pathway in BTBR mice. We investigated the effect of resveratrol treatment on TLR2, TLR3, TLR4, NF-κB, and inducible nitric oxide synthase (iNOS or NOS2) levels in CD4 spleen cells. We also assessed the effect of resveratrol treatment on TLR2, TLR3, TLR4, NF-κB, iNOS, and cyclooxygenase (COX-2) mRNA expression levels in the brain tissue. We further explored TLR2, TLR4, NF-κB, iNOS, and COX-2 protein expression levels in the brain tissue. Resveratrol treatment on BTBR mice significantly decreased CD4+TLR2+, CD4+TLR3+, CD4+TLR4+ CD4+NF-κB+, and CD4+iNOS+ levels in spleen cells. Resveratrol treatment on BTBR mice decreased TLR2, TLR3, TLR4, NF-κB, iNOS, and COX-2 mRNA expression levels in brain tissue. Moreover, resveratrol treatment resulted in decreased protein expression of TLR2, TLR3, TLR4, NF-κB, iNOS, and COX-2 in brain tissue. Taken together, these results indicate that resveratrol treatment improves neuroimmune dysregulation through the inhibition of proinflammatory mediators and TLRs\u002FNF-κB transcription factor signaling, which might be help devise future therapies for neuroimmune disorders.",{"EN":133},"Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf\u002FJ Mice",{"VOID":135},"10.1007\u002Fs12017-018-8483-0","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12017-018-8483-0",[141,160,183,196,208,221],{"id":142,"sortIndex":143,"researcher":20,"roles":144,"affiliations":146,"properties":157},"984d849c-fb02-46d7-9672-67c9f3bf887e",3,[145],"AUTHOR",[147],{"id":20,"sortIndex":21,"affiliation":148,"properties":20},{"id":149,"createTime":150,"updateTime":151,"relativeEntities":152,"slug":153,"properties":154,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"15996d28-e144-4b04-8303-a603843a0d2b","2023-12-23T09:04:52.403+00:00","2024-10-12T03:08:37.030+00:00",[],"Department-of-Pharmacology-and-Toxicology-College-of-Pharmacy-King-Saud-University-Riyadh-Kingdom-of-Saudi-Arabia",{"title":155},{"VI":156},"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia",{"title":158},{"VI":159},"Mohammad Z. 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Human Genetics, 131, 1081–1087.",{"doi":533},"10.1007\u002Fs00439-011-1131-5",{"id":20,"text":535,"url":20,"identifiers":536},"Cheng, J., Wang, Y., Zhou, K., Wang, L., Li, J., Zhuang, Q., et al. (2014). Male-specific association between dopamine receptor D4 gene methylation and schizophrenia. PLoS ONE, 9, e89128.",{"doi":537},"10.1371\u002Fjournal.pone.0089128",{"id":20,"text":539,"url":20,"identifiers":540},"da Huang, W., Sherman, B. T., & Lempicki, R. A. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols, 4, 44–57.",{"doi":541},"10.1038\u002Fnprot.2008.211",{"id":20,"text":543,"url":20,"identifiers":544},"Dedeurwaerder, S., Defrance, M., Calonne, E., Denis, H., Sotiriou, C., & Fuks, F. (2011). Evaluation of the Infinium Methylation 450 K technology. Epigenomics, 3, 771–784.",{"doi":545},"10.2217\u002Fepi.11.105",{"id":20,"text":547,"url":20,"identifiers":548},"Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., et al. (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Human Molecular Genetics, 20, 4786–4796.",{"doi":549},"10.1093\u002Fhmg\u002Fddr416",{"id":20,"text":551,"url":20,"identifiers":552},"Dong, E., Nelson, M., Grayson, D. R., Costa, E., & Guidotti, A. (2008). Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proceedings of the National Academy of Sciences usa, 105, 13614–13619.",{"doi":553},"10.1073\u002Fpnas.0805493105",{"id":20,"text":555,"url":20,"identifiers":556},"Gallia, G. L., Johnson, E. M., & Khalili, K. (2000). Puralpha: A multifunctional single-stranded DNA- and RNA-binding protein. Nucleic Acids Research, 28, 3197–3205.",{"doi":557},"10.1093\u002Fnar\u002F28.17.3197",{"id":20,"text":559,"url":20,"identifiers":560},"Gejman, P. V., Sanders, A. R., & Kendler, K. S. (2011). 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Methylation subtypes and large-scale epigenetic alterations in gastric cancer. Science Translational Medicine, 4, 156.",{"doi":724},"10.1126\u002Fscitranslmed.3004504",{"id":726,"createTime":727,"updateTime":728,"relativeEntities":729,"slug":730,"properties":731,"entityType":136,"verifyStatus":137,"verifyTime":728,"verifyNote":138,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":740,"fullTextUrl":20,"authors":741,"publicationType":233,"publisherRelationship":868,"citationCount":20,"citationInfo":20,"publishDate":902,"publishYear":903,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":270},"e8cca57d-8cf7-4f6d-9afa-80d13b210d59","2024-01-30T09:02:55.455+00:00","2025-01-13T23:53:18.578+00:00",[],"Global-MicroRNA-Expression-Profiling-Reveals-Differential-Expression-of-Target-Genes-in-6-Hydroxydopamine-injured-MN9D-Cells",{"references":732,"abstract":734,"title":736,"doi":738},{"VOID":733},"Asikainen, S., Rudgalvyte, M., Heikkinen, L., et al. (2010). 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Neuropathology and Applied Neurobiology, 36(4), 320–330.\nSleiman, S. F., Langley, B. C., Basso, M., et al. (2011). Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. Journal of Neuroscience, 31(18), 6858–6870.\nSonntag, K. C. (2010). MicroRNAs and deregulated gene expression networks in neurodegeneration. Brain Research, 1338, 48–57.\nSoto-Otero, R., Méndez-Alvarez, E., Hermida-Ameijeiras, A., et al. (2000). Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: Potential implication in relation to the pathogenesis of Parkinson’s disease. Journal of Neurochemistry, 74(4), 1605–1612.\nSuzuki, H. I., Yamagata, K., Sugimoto, K., et al. (2009). Modulation of microRNA processing by p53. Nature, 460(7254), 529–533.",{"EN":735},"Recent evidence indicates that microRNAs (miRNAs) play a key role in neurodegenerative diseases. However, little is known about how these small RNAs contribute to dopaminergic neuronal apoptosis. Here, we profiled the expression of miRNAs in MN9D cells with and without 6-hydroxydopamine (6-OHDA) treatment by miRCURY™ LNA microRNA arrays. We identified six miRNAs (miR-668-3p, let-7d-3p, miR-3077-3p, miR-665-5p, miR-99b-3p, and miR-323-3p) that were significantly lower and five miRNAs (miR-875, miR-207, miR-425-5p, miR-19b-3p, and miR-338-3p) that were significantly higher after 6-OHDA treatment. Among them, five have been demonstrated to be implicated in neurodegenerative diseases. Consistent with our prediction, the deregulated miRNA’s target mRNAs, such as peroxiredoxin III (Prx III) and Myc, also showed changes in their expression levels. Furthermore, using a dual-luciferase reporter assay, we confirmed that Prx III was a direct target gene of miR-875. Taken together, these findings demonstrate that changes in miRNA expression occur after 6-OHDA treatment and suggest that miRNAs and their predicted targets have a potential role in apoptosis of MN9D cells.",{"EN":737},"Global MicroRNA Expression Profiling Reveals Differential Expression of Target Genes in 6-Hydroxydopamine-injured MN9D Cells",{"VOID":739},"10.1007\u002Fs12017-013-8244-z","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12017-013-8244-z",[742,757,769,781,793,808,820,849],{"id":743,"sortIndex":112,"researcher":20,"roles":744,"affiliations":745,"properties":754},"1c7f5c0f-f4f3-48cf-b8a4-da3c4d75cb8e",[145],[746],{"id":20,"sortIndex":21,"affiliation":747,"properties":20},{"id":748,"createTime":749,"updateTime":749,"relativeEntities":750,"slug":20,"properties":751,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"c84f17db-e10c-454d-a704-1b8ac584ff21","2023-12-24T18:25:14.855+00:00",[],{"title":752},{"VI":753},"Department of Human Anatomy and Neurobiology, Xuzhou Medical College, Xuzhou, China",{"title":755},{"VI":756},"Hui-Zhen Chen",{"id":758,"sortIndex":185,"researcher":20,"roles":759,"affiliations":760,"properties":766},"a8c869f5-efbb-48cd-aca0-ab9132ab6e87",[145],[761],{"id":20,"sortIndex":21,"affiliation":762,"properties":20},{"id":748,"createTime":749,"updateTime":749,"relativeEntities":763,"slug":20,"properties":764,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":765},{"VI":753},{"title":767},{"VI":768},"Meng Wang",{"id":770,"sortIndex":162,"researcher":20,"roles":771,"affiliations":772,"properties":778},"49588586-e5f3-47ae-a803-4c90e0546668",[145],[773],{"id":20,"sortIndex":21,"affiliation":774,"properties":20},{"id":748,"createTime":749,"updateTime":749,"relativeEntities":775,"slug":20,"properties":776,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":777},{"VI":753},{"title":779},{"VI":780},"Li Wang",{"id":782,"sortIndex":210,"researcher":20,"roles":783,"affiliations":784,"properties":790},"5130292f-c95b-4c80-9af1-ab60770047fc",[145],[785],{"id":20,"sortIndex":21,"affiliation":786,"properties":20},{"id":748,"createTime":749,"updateTime":749,"relativeEntities":787,"slug":20,"properties":788,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":789},{"VI":753},{"title":791},{"VI":792},"Fang-Fang Chen",{"id":794,"sortIndex":113,"researcher":20,"roles":795,"affiliations":796,"properties":805},"13adb2e7-91c0-4104-91d1-0ea8acfa03f9",[145],[797],{"id":20,"sortIndex":21,"affiliation":798,"properties":20},{"id":799,"createTime":800,"updateTime":800,"relativeEntities":801,"slug":20,"properties":802,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"ed646a7e-3863-4ab8-b769-43a1a78b0b71","2024-01-30T09:02:55.573+00:00",[],{"title":803},{"VI":804},"Department of Human Anatomy, Histology and Embryology, School of the Basic Medicine, The Fourth Military Medical University, Xi’an, China",{"title":806},{"VI":807},"Yun-Qing Li",{"id":809,"sortIndex":143,"researcher":20,"roles":810,"affiliations":811,"properties":817},"c12e65e2-05b6-42c0-93d7-2f90ececfc1d",[145],[812],{"id":20,"sortIndex":21,"affiliation":813,"properties":20},{"id":748,"createTime":749,"updateTime":749,"relativeEntities":814,"slug":20,"properties":815,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":816},{"VI":753},{"title":818},{"VI":819},"Feng Li",{"id":821,"sortIndex":21,"researcher":20,"roles":822,"affiliations":823,"properties":846},"3a64781d-1e43-473b-b537-be9f1f240cdd",[145],[824,831,836],{"id":825,"sortIndex":112,"affiliation":826,"properties":830},"41a31887-a712-4b41-9a0b-9b92ae21a15c",{"id":799,"createTime":800,"updateTime":800,"relativeEntities":827,"slug":20,"properties":828,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":829},{"VI":804},{},{"id":20,"sortIndex":21,"affiliation":832,"properties":20},{"id":748,"createTime":749,"updateTime":749,"relativeEntities":833,"slug":20,"properties":834,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":835},{"VI":753},{"id":837,"sortIndex":210,"affiliation":838,"properties":845},"ebdd5fa7-e89d-4f68-b84c-7d26b6548ba9",{"id":839,"createTime":840,"updateTime":840,"relativeEntities":841,"slug":20,"properties":842,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"26fd6b2b-03a1-407d-a302-f6e2c392aa07","2023-12-12T19:27:10.921+00:00",[],{"title":843},{"VI":844},"Department of Pathophysiology, Xuzhou Medical College, Xuzhou, China",{},{"title":847},{"VI":848},"Li Li",{"id":850,"sortIndex":58,"researcher":20,"roles":851,"affiliations":852,"properties":865},"3b8255f4-67d3-46aa-b66a-037e1d15d838",[145],[853,860],{"id":854,"sortIndex":112,"affiliation":855,"properties":859},"e85e5670-6b2f-41eb-b51e-f9802c85433b",{"id":799,"createTime":800,"updateTime":800,"relativeEntities":856,"slug":20,"properties":857,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":858},{"VI":804},{},{"id":20,"sortIndex":21,"affiliation":861,"properties":20},{"id":748,"createTime":749,"updateTime":749,"relativeEntities":862,"slug":20,"properties":863,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":864},{"VI":753},{"title":866},{"VI":867},"Dian-Shuai Gao",{"url":740,"publisher":869,"properties":897},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":870,"slug":10,"properties":871,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":875,"manageAffiliations":876,"indexDatabases":877,"url":20,"thumbnailPath":20,"statistic":892,"gsStatistic":20,"type":116,"analyzePriority":20},[],{"issn":872,"title":873,"url":874},{"VOID":13},{"EN":15},{"VOID":17},[],[],[878,885],{"id":72,"indexDatabase":879,"url":20,"indexYears":20,"academicFieldIds":884,"indexDatabaseRanking":20},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":880,"label":881,"description":882,"key":83,"publicationTags":883,"standard":20},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[88],{"id":90,"indexDatabase":886,"url":103,"indexYears":104,"academicFieldIds":891,"indexDatabaseRanking":20},{"id":92,"createTime":93,"updateTime":94,"relativeEntities":887,"label":888,"description":889,"key":100,"publicationTags":890,"standard":20},[],{"EN":97,"VI":97},{"EN":97,"VI":99},[102],[106,107,108],{"impactFactor":21,"impactFactorByYear":893,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":58,"totalPublicationByYear":894,"totalCitation":21,"totalCitationByYear":895,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":896,"hindexLast5Year":21,"hindex":21},{},{"2002":112,"2024":113},{},{},{"volume":898,"pages":900},{"VOID":899},"15",{"VOID":901},"593-604","2013-07-12",2013,{"id":905,"createTime":906,"updateTime":906,"relativeEntities":907,"slug":20,"properties":908,"entityType":136,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":917,"fullTextUrl":20,"authors":918,"publicationType":233,"publisherRelationship":1009,"citationCount":20,"citationInfo":20,"publishDate":1041,"publishYear":1042,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":270},"dba80a20-34f0-43dc-b7df-250b5825ee31","2023-12-12T23:52:48.759+00:00",[],{"references":909,"abstract":911,"title":913,"doi":915},{"VOID":910},"Arellano, J. I., Muñoz, A., Ballesteros-Yáñez, I., Sola, R. G., & DeFelipe, J. (2004). Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain, 127, 45–64.\nArteel, G. E., Thurman, R. G., & Raleigh, J. A. (1998). Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. European Journal of Biochemistry, 253, 743–750.\nArteel, G. E., Thurman, R. G., Yates, J. M., & Raleigh, J. A. (1995). Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver. British Journal of Cancer, 72, 889–895.\nBenini, R., Longo, D., Biagini, G., & Avoli, M. (2011). Perirhinal cortex hyperexcitability in pilocarpine-treated epileptic rats. Hippocampus, 21, 702–713.\nBergeron, M., Yu, A. Y., Solway, K. E., Semenza, G. L., & Sharp, F. R. (1999). Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. European Journal of Neuroscience, 11, 4159–4170.\nBernhardt, B. C., Worsley, K. J., Kim, H., Evans, A. C., Bernasconi, A., & Bernasconi, N. (2009). Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy. Neurology, 72, 1747–1754.\nBiagini, G., Baldelli, E., Longo, D., Contri, M. B., Guerrini, U., Sironi, L., et al. (2008). Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. Journal of Neuropathology and Experimental Neurology, 67, 687–701.\nBiagini, G., Baldelli, E., Longo, D., Pradelli, L., Zini, I., Rogawski, M. A., et al. (2006). Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy. Experimental Neurology, 201, 519–524.\nBiagini, G., D’Arcangelo, G., Baldelli, E., D’Antuono, M., Tancredi, V., & Avoli, M. (2005). Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus. NeuroMolecular Medicine, 7, 325–342.\nBiagini, G., Pich, E. M., Carani, C., Marrama, P., Gustafsson, J. A., Fuxe, K., et al. (1993). Indole-pyruvic acid, a tryptophan ketoanalogue, antagonizes the endocrine but not the behavioral effects of repeated stress in a model of depression. Biological Psychiatry, 33, 712–719.\nBlümcke, I., Thom, M., Aronica, E., Armstrong, D. D., Vinters, H. V., Palmini, A., et al. (2011). The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia, 52, 158–174.\nBortel, A., Longo, D., de Guzman, P., Dubeau, F., Biagini, G., & Avoli, M. (2010). Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats. European Journal of Neuroscience, 31, 2014–2023.\nCao, G., Pei, W., Lan, J., Stetler, R. A., Luo, Y., Nagayama, T., et al. (2001). Caspase activated DNase\u002FDNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. Journal of Neuroscience, 21, 4678–4690.\nChen, C., Hu, Q., Yan, J., Lei, J., Qin, L., Shi, X., et al. (2007). Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1α and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model. Journal of Neurochemistry, 102, 1831–1841.\nCoan, A. C., Appenzeller, S., Bonilha, L., Li, L. M., & Cendes, F. (2009). Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy. Neurology, 73, 834–842.\nCuria, G., Longo, D., Biagini, G., Jones, R. S., & Avoli, M. (2008). The pilocarpine model of temporal lobe epilepsy. Journal of Neuroscience Methods, 172, 143–157.\nFabene, P. F., Merigo, F., Galiè, M., Benati, D., Bernardi, P., Farace, P., et al. (2007). Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms. PLoS ONE, 2, e1105.\nFaraco, G., Fossati, S., Bianchi, M. E., Patrone, M., Pedrazzi, M., Sparatore, B., et al. (2007). High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. Journal of Neurochemistry, 103, 590–603.\nFeast, A., Martinian, L., Liu, J., Catarino, C. B., Thom, M., & Sisodiya, S. M. (2012). Investigation of hypoxia-inducible factor-1α in hippocampal sclerosis: A postmortem study. Epilepsia, 53, 1349–1359.\nGeneslaw, A. S., Zhao, M., Ma, H., & Schwartz, T. H. (2011). Tissue hypoxia correlates with intensity of interictal spikes. Journal of Cerebral Blood Flow and Metabolism, 31, 1394–1402.\nGorter, J. A., van Vliet, E. A., Aronica, E., & Lopes da Silva, F. H. (2011). Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons. European Journal of Neuroscience, 13, 657–669.\nGualtieri, F., Curia, G., Marinelli, C., & Biagini, G. (2012). Increased perivascular laminin predicts damage to astrocytes in CA3 and piriform cortex following chemoconvulsive treatments. Neuroscience, 218, 278–294.\nHayakawa, K., Qiu, J., & Lo, E. H. (2010). Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Annals of the New York Academy of Sciences, 1207, 50–57.\nHelton, R., Cui, J., Scheel, J. R., Ellison, J. A., Ames, C., Gibson, C., et al. (2005). Brain-specific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxic-ischemic damage. Journal of Neuroscience, 25, 4099–4107.\nHempel, C., Combes, V., Hunt, N. H., Kurtzhals, J. A., & Grau, G. E. (2011). CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin. American Journal of Pathology, 179, 1939–1950.\nHenshall, D. C., Clark, R. S., Adelson, P. D., Chen, M., Watkins, S. C., & Simon, R. P. (2000). Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy. Neurology, 55, 250–257.\nHenshall, D. C., & Simon, R. P. (2005). Epilepsy and apoptosis pathways. Journal of Cerebral Blood Flow and Metabolism, 25, 1557–1572.\nHossain, M. A. (2005). Molecular mediators of hypoxic-ischemic injury and implications for epilepsy in the developing brain. Epilepsy & Behavior, 7, 204–213.\nHota, K. B., Hota, S. K., Srivastava, R. B., & Singh, S. B. (2012). Neuroglobin regulates hypoxic response of neuronal cells through Hif-1α- and Nrf2-mediated mechanism. Journal of Cerebral Blood Flow and Metabolism, 32, 1046–1060.\nIngvar, M. (1986). Cerebral blood flow and metabolic rate during seizures. Relationship to epileptic brain damage. Annals of the New York Academy of Sciences, 462, 194–206.\nItoh, T., Takita, M., Sorelle, J. A., Sugimoto, K., Chujo, D., Qin, H., et al. (2012). Correlation of released HMGB1 levels with the degree of islet damage in mice and humans and with the outcomes of islet transplantation in mice. Cell Transplantation. doi:10.3727\u002F096368912X640592.\nKim, J. B., Sig Choi, J., Yu, Y. M., Nam, K., Piao, C. S., Kim, S. W., et al. (2006). HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. Journal of Neuroscience, 26, 6413–6421.\nKizaka-Kondoh, S., & Konse-Nagasawa, H. (2009). Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia. Cancer Science, 100, 1366–1373.\nKobayashi, M., & Buckmaster, P. S. (2003). Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy. Journal of Neuroscience, 23, 2440–2452.\nKreisman, N. R., Magee, J. C., & Brizzee, B. L. (1991). Relative hypoperfusion in rat cerebral cortex during recurrent seizures. Journal of Cerebral Blood Flow and Metabolism, 11, 77–87.\nLi, L., Qu, Y., Li, J., Xiong, Y., Mao, M., & Mu, D. (2007). Relationship between HIF-1α expression and neuronal apoptosis in neonatal rats with hypoxia-ischemia brain injury. Brain Research, 1180, 133–139.\nLi, Y., Zhou, C., Calvert, J. W., Colohan, A. R., & Zhang, J. H. (2005). Multiple effects hyperbaric oxygen on the expression of HIF-1α and apoptotic genes in a global ischemia-hypotension rat model. Experimental Neurology, 191, 198–210.\nMa, H., Geneslaw, A., Zhao, M., Suh, M., Perry, C., & Schwartz, T. H. (2009). The importance of latency in the focality of perfusion and oxygenation changes associated with triggered afterdischarges in human cortex. Journal of Cerebral Blood Flow and Metabolism, 29, 1003–1014.\nMaroso, M., Balosso, S., Ravizza, T., Liu, J., Aronica, E., Iyer, A. M., et al. (2010). Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nature Medicine, 16, 413–419.\nMathern, G. W., Babb, T. L., Pretorius, J. K., & Leite, J. P. (1995). Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. Journal of Neuroscience, 15, 3990–4004.\nMeldrum, B. S. (2002). Concept of activity-induced cell death in epilepsy: Historical and contemporary perspectives. Progress in Brain Research, 135, 3–11.\nMeldrum, B. S., & Nilsson, B. (1976). Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline. Brain, 99, 523–542.\nMitchell, J., Gatherer, M., & Sundstrom, L. E. (1995). Loss of hilar somatostatin neurons following tetanus toxin-induced seizures. Acta Neuropathologica, 89, 425–430.\nMott, R. T., Thore, C. R., Moody, D. M., Glazier, S. S., Ellis, T. L., & Brown, W. R. (2009). Reduced ratio of afferent to total vascular density in mesial temporal sclerosis. Journal of Neuropathology and Experimental Neurology, 68, 1147–1154.\nNdode-Ekane, X. E., Hayward, N., Gröhn, O., & Pitkänen, A. (2010). Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. Neuroscience, 166, 312–332.\nNevander, G., Ingvar, M., Auer, R., & Siesjö, B. K. (1985). Status epilepticus in well-oxygenated rats causes neuronal necrosis. Annals of Neurology, 18, 281–290.\nNiquet, J., Baldwin, R. A., Allen, S. G., Fujikawa, D. G., & Wasterlain, C. G. (2003). Hypoxic neuronal necrosis: Protein synthesis-independent activation of a cell death program. Proceedings of the National academy of Sciences of the United States of America, 100, 2825–2830.\nNorthington, F. J., Chavez-Valdez, R., & Martin, L. J. (2011). Neuronal cell death in neonatal hypoxia-ischemia. Annals of Neurology, 69, 743–758.\nNoto, T., Furuichi, Y., Ishiye, M., Matsuoka, N., Aramori, I., Mutoh, S., et al. (2006). Temporal and topographic profiles of tissue hypoxia following transient focal cerebral ischemia in rats. Journal of Veterinary Medicine Science, 68, 803–807.\nNoto, T., Furuichi, Y., Ishiye, M., Matsuoka, N., Aramori, I., Mutoh, S., et al. (2007). Tacrolimus (FK506) limits accumulation of granulocytes and platelets and protects against brain damage after transient focal cerebral ischemia in rat. Biology and Pharmaceutical Bulletin, 30, 313–317.\nPlum, F., Posner, J. B., & Troy, B. (1968). Cerebral metabolic and circulatory responses to induced convulsions in animals. Archives of Neurology, 18, 1–13.\nQiu, J., Nishimura, M., Wang, Y., Sims, J. R., Qiu, S., Savitz, S. I., et al. (2008). Early release of HMGB-1 from neurons after the onset of brain ischemia. Journal of Cerebral Blood Flow and Metabolism, 28, 927–938.\nRacine, R. J. (1972). 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L., Agani, F., Feldser, D., Iyer, N., Kotch, L., Laughner, E., et al. (2000). Hypoxia, HIF-1, and the pathophysiology of common human diseases. Advances in Experimental Medicine and Biology, 475, 123–130.\nSiesjö, B. K., Ingvar, M., & Wieloch, T. (1986). Cellular and molecular events underlying epileptic brain damage. Annals of the New York Academy of Sciences, 462, 207–223.\nSimon, R. P. (1985). Physiologic consequences of status epilepticus. Epilepsia, 26(Suppl 1), S58–S66.\nSloviter, R. S. (1987). Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science, 235, 73–76.\nSundstrom, L. E., Brana, C., Gatherer, M., Mepham, J., & Rougier, A. (2001). Somatostatin- and neuropeptide Y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy. Brain, 124, 688–697.\nThored, P., Wood, J., Arvidsson, A., Cammenga, J., Kokaia, Z., & Lindvall, O. (2007). 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Brain Pathology, 21, 249–262.\nYu, C. H., Moon, C. T., Sur, J. H., Chun, Y. I., Choi, W. H., & Yhee, J. Y. (2011). Serial expression of hypoxia inducible factor-1α and neuronal apoptosis in hippocampus of rats with chronic ischemic brain. Journal of Korean Neurosurgical Society, 50, 481–485.\nZhao, M., Ma, H., Suh, M., & Schwartz, T. H. (2009). Spatiotemporal dynamics of perfusion and oximetry during ictal discharges in the rat neocortex. Journal of Neuroscience, 29, 2814–2823.",{"EN":912},"An early but transient decrease in oxygen availability occurs during experimentally induced seizures. Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P \u003C 0.01, 120 vs 60 and 30 min). All the animals exposed to SE were immunopositive to pimonidazole, but a different scenario emerged during epileptogenesis when a decrease in pimonidazole-immunostained cells occurred from 7 to 14 days, so that only 1 out of 4 rats presented with pimonidazole-immunopositive cells. Pimonidazole-immunoreactive cells robustly reappeared at 21 days post-SE induction when all animals (7 out of 7) had developed spontaneous recurrent seizures. Specific neuronal markers revealed that immunopositivity to pimonidazole was present in cells identified by neuropeptide Y (NPY) or somatostatin antibodies. At variance, neurons immunopositive to parvalbumin or cholecystokinin were not immunopositive to pimonidazole. Pimonidazole-immunopositive neurons expressed remarkable immunoreactivity to hypoxia-inducible factor 1α (HIF-1α). Interestingly, surgical samples obtained from pharmacoresistant patients showed neurons co-labeled by HIF-1α and NPY antibodies. These interneurons, along with parvalbumin-positive interneurons that were negative to HIF-1α, showed immunopositivity to markers of cell damage, such as high-mobility group box 1 in the cytoplasm and cleaved caspase-3 in the nucleus. These findings suggest that interneurons are continuously endangered in rodent and human epileptogenic tissue. The presence of hypoxia and cell damage markers in NPY interneurons of rats and patients presenting with recurrent seizures indicates a mechanism of selective vulnerability in a specific neuronal subpopulation.",{"EN":914},"Hypoxia Markers are Expressed in Interneurons Exposed to Recurrent Seizures",{"VOID":916},"10.1007\u002Fs12017-012-8203-0","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs12017-012-8203-0",[919,934,949,961,973,985,997],{"id":920,"sortIndex":162,"researcher":20,"roles":921,"affiliations":922,"properties":931},"3d6ec48f-1003-4e30-ac7c-dc6b0b836ef4",[145],[923],{"id":20,"sortIndex":21,"affiliation":924,"properties":20},{"id":925,"createTime":926,"updateTime":926,"relativeEntities":927,"slug":20,"properties":928,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"37c2c468-a55d-4ff9-9ca6-d206cec9f0f7","2023-12-12T23:52:25.167+00:00",[],{"title":929},{"VI":930},"Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Ospedale NOCSAE, Università di Modena e Reggio Emilia, Modena, Italy",{"title":932},{"VI":933},"Stefano Meletti",{"id":935,"sortIndex":113,"researcher":20,"roles":936,"affiliations":937,"properties":946},"67bd1981-9aac-42db-b5c4-3f7d14aa83f0",[145],[938],{"id":20,"sortIndex":21,"affiliation":939,"properties":20},{"id":940,"createTime":941,"updateTime":941,"relativeEntities":942,"slug":20,"properties":943,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"83834dab-99e9-471e-80ef-fba98717c965","2023-12-12T23:52:48.771+00:00",[],{"title":944},{"VI":945},"Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Laboratorio di Epilettologia Sperimentale, Università di Modena e Reggio Emilia, Modena, Italy",{"title":947},{"VI":948},"Giuseppe Biagini",{"id":950,"sortIndex":112,"researcher":20,"roles":951,"affiliations":952,"properties":958},"917fa145-7131-482d-8641-c88d1dcb8601",[145],[953],{"id":20,"sortIndex":21,"affiliation":954,"properties":20},{"id":940,"createTime":941,"updateTime":941,"relativeEntities":955,"slug":20,"properties":956,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":957},{"VI":945},{"title":959},{"VI":960},"Carla Marinelli",{"id":962,"sortIndex":21,"researcher":20,"roles":963,"affiliations":964,"properties":970},"c34b3bf6-5f8b-4e98-b54c-2a30f0476672",[145],[965],{"id":20,"sortIndex":21,"affiliation":966,"properties":20},{"id":940,"createTime":941,"updateTime":941,"relativeEntities":967,"slug":20,"properties":968,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":969},{"VI":945},{"title":971},{"VI":972},"Fabio Gualtieri",{"id":974,"sortIndex":143,"researcher":20,"roles":975,"affiliations":976,"properties":982},"41c4da4f-cc26-4f8b-8435-2c02ffba2100",[145],[977],{"id":20,"sortIndex":21,"affiliation":978,"properties":20},{"id":925,"createTime":926,"updateTime":926,"relativeEntities":979,"slug":20,"properties":980,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":981},{"VI":930},{"title":983},{"VI":984},"Matteo Pugnaghi",{"id":986,"sortIndex":185,"researcher":20,"roles":987,"affiliations":988,"properties":994},"823c87dd-f2b5-4faa-86ae-7f7ed9836aba",[145],[989],{"id":20,"sortIndex":21,"affiliation":990,"properties":20},{"id":925,"createTime":926,"updateTime":926,"relativeEntities":991,"slug":20,"properties":992,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":993},{"VI":930},{"title":995},{"VI":996},"Paolo F. 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The implication of lipid genetic susceptibility on brain gene expression is yet to be investigated. The current study included 192 brain samples from AD patients who were enrolled in the ROSMAP study. The samples were genotyped and imputed to the HRC Reference Panel. Lipid polygenetic risk score was constructed from the weighted sum of genetic variants associated with low-density lipoprotein cholesterol (LDL-C). The gene expression was profiled by RNA sequencing, and the  association of gene expression with lipid polygenetic risk scores was tested by linear regression models adjusted for age, sex and APOE e4 alleles. Three genes were found to associate with lipid polygenetic risk scores, including HMCN2 (P = 3.6 × 10–7), PDLIM5 (P = 1.2 × 10–6), and FHL5 (P = 2.0 × 10–6). Network analysis revealed multiple related pathways, including dopaminergic synapse (P = 4.5 × 10–5), circadian entrainment (P = 1.1 × 10–4), and cholinergic synapse (P = 2.3 × 10–4). Our study underscores the importance of lipid regulation and metabolism to AD heterogeneity.",{"EN":1055},"Transcriptomic Heterogeneity of Alzheimer’s Disease Associated with Lipid Genetic Risk",{"VOID":1057},"10.1007\u002Fs12017-020-08610-6","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs12017-020-08610-6",[1060,1075,1100,1112],{"id":1061,"sortIndex":143,"researcher":20,"roles":1062,"affiliations":1063,"properties":1072},"70dbed03-6693-463d-90bc-27b2c199ea6d",[145],[1064],{"id":20,"sortIndex":21,"affiliation":1065,"properties":20},{"id":1066,"createTime":1067,"updateTime":1067,"relativeEntities":1068,"slug":20,"properties":1069,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"221fcf48-34b5-4103-b981-e76a83d591cc","2023-12-07T00:29:47.614+00:00",[],{"title":1070},{"VI":1071},"Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, 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Kennerson; citation_volume=37; citation_publication_date=2005; citation_pages=289-294; citation_id=CR201",{"EN":1168},"We review the putative functions and malfunctions of proteins encoded by genes mutated in Charcot-Marie-Tooth disease (CMT; inherited motor and sensory neuropathies) in normal and affected peripheral nerves. Some proteins implicated in demyelinating CMT, peripheral myelin protein 22, protein zero (P0), and connexin32 (Cx32\u002FGJB1) are crucial components of myelin. Periaxin is involved in connecting myelin to the surrounding basal lamina. Early growth response 2 (EGR2) and Sox10 are transcriptional regulators of myelin genes. Mutations in the small integral membrane protein of lysosome\u002Flate endosome, the myotubularin-related protein 2 (MTMR2), and MTMR13\u002Fset-binding factor 2 are involved in vesicle and membrane transport and the regulation of protein degradation. Pathomechanisms related to alterations of these processes are a widespread phenomenon in demyelinating neuropathies because mutations of myelin components may also affect protein biosynthesis, transport, and\u002For degradation. Related disease mechanisms are also involved inaxonal neuropathies although there is considerably more functional heterogeneity. Some mutations, most notably in P0, GJB1, ganglioside-induced differentiation-associated protein 1 (GDAP1), neurofilament light chain (NF-L), and dynamin 2 (DNM2), can result in demyelinating or axonal neuropathies introducing additional complexity in the pathogenesis. Often, this relates to the intinate connection between Schwann cells and neurons\u002Faxons leading to axonal damage even if the mutation-caused defect is Schwann-cell-autonomous. This mechanisms is likely for P0 and Cx32 mutations and provides the basis for the unifying hypothesis that also demyelinating neuropathies develop into functional axonopathies. In GDAP1 and DNM2 mutants, both Schwann cells and axons\u002Fneurons might be directly affected. NF-L mutants have a primary neuronal defect but also cause demyelination. The major challenge ahead lies in determining the individual contributions by neurons and Schwann cells to the pathology over time and to delineate the detailed molecular functions of the proteins associated with CMT in health and disease.",{"EN":1170},"Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease",{"VOID":1172},"10.1385\u002FNMM:8:1-2:217","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1385\u002FNMM:8:1-2:217","https:\u002F\u002Flink.springer.com\u002Fcontent\u002Fpdf\u002F10.1385\u002FNMM:8:1-2:217.pdf",[1176,1191,1203],{"id":1177,"sortIndex":21,"researcher":20,"roles":1178,"affiliations":1179,"properties":1188},"6a83f7bd-4c05-4e57-b74d-c3f7d0fdce28",[145],[1180],{"id":20,"sortIndex":21,"affiliation":1181,"properties":20},{"id":1182,"createTime":1183,"updateTime":1183,"relativeEntities":1184,"slug":20,"properties":1185,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"bd53d819-4060-4b08-8d07-de70403ff846","2024-01-20T23:41:41.224+00:00",[],{"title":1186},{"VI":1187},"Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, Zürich, Switzerland",{"title":1189},{"VI":1190},"Niemann, Axel",{"id":1192,"sortIndex":210,"researcher":20,"roles":1193,"affiliations":1194,"properties":1200},"a617a807-d9c3-4ddc-825d-fe9f14106c6d",[145],[1195],{"id":20,"sortIndex":21,"affiliation":1196,"properties":20},{"id":1182,"createTime":1183,"updateTime":1183,"relativeEntities":1197,"slug":20,"properties":1198,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1199},{"VI":1187},{"title":1201},{"VI":1202},"Suter, Ueli",{"id":1204,"sortIndex":112,"researcher":20,"roles":1205,"affiliations":1206,"properties":1212},"0f98a919-a4af-4a47-8781-48cea92477a1",[145],[1207],{"id":20,"sortIndex":21,"affiliation":1208,"properties":20},{"id":1182,"createTime":1183,"updateTime":1183,"relativeEntities":1209,"slug":20,"properties":1210,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1211},{"VI":1187},{"title":1213},{"VI":1214},"Berger, Philipp",{"url":1173,"publisher":1216,"properties":1244},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1217,"slug":10,"properties":1218,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1222,"manageAffiliations":1223,"indexDatabases":1224,"url":20,"thumbnailPath":20,"statistic":1239,"gsStatistic":20,"type":116,"analyzePriority":20},[],{"issn":1219,"title":1220,"url":1221},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1225,1232],{"id":72,"indexDatabase":1226,"url":20,"indexYears":20,"academicFieldIds":1231,"indexDatabaseRanking":20},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":1227,"label":1228,"description":1229,"key":83,"publicationTags":1230,"standard":20},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[88],{"id":90,"indexDatabase":1233,"url":103,"indexYears":104,"academicFieldIds":1238,"indexDatabaseRanking":20},{"id":92,"createTime":93,"updateTime":94,"relativeEntities":1234,"label":1235,"description":1236,"key":100,"publicationTags":1237,"standard":20},[],{"EN":97,"VI":97},{"EN":97,"VI":99},[102],[106,107,108],{"impactFactor":21,"impactFactorByYear":1240,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":58,"totalPublicationByYear":1241,"totalCitation":21,"totalCitationByYear":1242,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1243,"hindexLast5Year":21,"hindex":21},{},{"2002":112,"2024":113},{},{},{"volume":1245,"pages":1247,"issue":1249},{"VOID":1246},"8",{"VOID":1248},"217-241",{"VOID":1250},"1","2006-03-01",2006,{"id":1254,"createTime":1255,"updateTime":1255,"relativeEntities":1256,"slug":20,"properties":1257,"entityType":136,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1266,"fullTextUrl":20,"authors":1267,"publicationType":233,"publisherRelationship":1407,"citationCount":20,"citationInfo":20,"publishDate":1441,"publishYear":1442,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":270},"935861c6-996e-4fcd-bc18-bfafc8a30b3d","2024-01-11T23:40:48.796+00:00",[],{"references":1258,"abstract":1260,"title":1262,"doi":1264},{"VOID":1259},"Anang, J. 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Journal of Cellular and Molecular Medicine, 19(5), 1094–1102. https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjcmm.12504",{"EN":1261},"Alzheimer’s disease (AD), vascular dementia (VD), and Parkinson’s disease (PD) exert increasingly lethal or disabling effects on humans, but the associations among these diseases at the molecular level remain unclear. In our research, lists of genes related to these three diseases were acquired from public databases. We constructed gene–gene networks of the lists of disease-related genes using the STRING database and selected the plug-in MCODE as the most suitable method to divide the three disease-associated networks into modules through an entropy calculation. Notably, 1173 AD-related, 203 VD-related, and 722 PD-related genes as well as 72 overlapping genes were observed among the three diseases. By dividing the modules from the gene network, we divided the AD-related gene network into 27 modules, the VD-related gene network into 8 modules, and the PD-related gene network into 17 modules. After the enrichment analysis of each disease-related gene, 146 overlapping biological processes and 32 overlapping pathways were identified. Ultimately, through similarity analysis of the genes, biological processes, and pathways, we found that AD and VD were the most closely related at the biological process and pathway levels, with similarity coefficients of 0.2784 and 0.3626, respectively. After analyzing the overlapping gene network, we found that INS might play an important role in the network and that insulin and its signaling pathways may play a key role in these neurodegenerative diseases. Our research illustrates a new method for in-depth research on the three diseases, which may accelerate the progress of developing new therapeutics and may be applied to prevent neurodegenerative diseases.",{"EN":1263},"Revealing the Modular Similarities and Differences Among Alzheimer’s Disease, Vascular Dementia, and Parkinson’s Disease in Genomic Networks",{"VOID":1265},"10.1007\u002Fs12017-021-08670-2","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12017-021-08670-2",[1268,1283,1300,1312,1336,1351,1368,1380],{"id":1269,"sortIndex":143,"researcher":20,"roles":1270,"affiliations":1271,"properties":1280},"661dbff6-5a0c-448b-a023-25cd7cb5444a",[145],[1272],{"id":20,"sortIndex":21,"affiliation":1273,"properties":20},{"id":1274,"createTime":1275,"updateTime":1275,"relativeEntities":1276,"slug":20,"properties":1277,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"8e052ac1-50b4-4974-8316-09de6e3afe3c","2024-02-13T06:06:00.264+00:00",[],{"title":1278},{"VI":1279},"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China",{"title":1281},{"VI":1282},"Penglu Wei",{"id":1284,"sortIndex":58,"researcher":20,"roles":1285,"affiliations":1286,"properties":1297},"3436b646-fd96-4918-a318-06779de236da",[145],[1287],{"id":20,"sortIndex":21,"affiliation":1288,"properties":20},{"id":1289,"createTime":1290,"updateTime":1291,"relativeEntities":1292,"slug":1293,"properties":1294,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"7ea9cdba-55dc-4ccd-845b-00de1deb0f11","2023-12-30T20:32:07.827+00:00","2025-01-30T15:05:56.069+00:00",[],"Institute-of-Basic-Research-in-Clinical-Medicine-China-Academy-of-Chinese-Medical-Sciences-Beijing-China",{"title":1295},{"VI":1296},"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China",{"title":1298},{"VI":1299},"Zhong Wang",{"id":1301,"sortIndex":210,"researcher":20,"roles":1302,"affiliations":1303,"properties":1309},"b70869e6-1e11-4592-961f-2397a143bf67",[145],[1304],{"id":20,"sortIndex":21,"affiliation":1305,"properties":20},{"id":1289,"createTime":1290,"updateTime":1291,"relativeEntities":1306,"slug":1293,"properties":1307,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1308},{"VI":1296},{"title":1310},{"VI":1311},"Jun Liu",{"id":1313,"sortIndex":21,"researcher":20,"roles":1314,"affiliations":1315,"properties":1333},"83a2e0c1-d80a-47f0-bb7a-6595e67bb9e7",[145],[1316,1326],{"id":20,"sortIndex":21,"affiliation":1317,"properties":20},{"id":1318,"createTime":1319,"updateTime":1320,"relativeEntities":1321,"slug":1322,"properties":1323,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"8fe20f21-2d17-4b42-8c0f-ed45e90ba3a5","2023-12-19T16:17:37.700+00:00","2025-01-01T03:50:25.425+00:00",[],"School-of-Traditional-Chinese-Medicine-Beijing-University-of-Chinese-Medicine-Beijing-China",{"title":1324},{"VI":1325},"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China",{"id":1327,"sortIndex":112,"affiliation":1328,"properties":1332},"32018404-0910-4218-8abe-d829a3f0dfce",{"id":1289,"createTime":1290,"updateTime":1291,"relativeEntities":1329,"slug":1293,"properties":1330,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1331},{"VI":1296},{},{"title":1334},{"VI":1335},"Yafei Chen",{"id":1337,"sortIndex":162,"researcher":20,"roles":1338,"affiliations":1339,"properties":1348},"6daf0eb6-1887-47af-9028-0267cef7400c",[145],[1340],{"id":20,"sortIndex":21,"affiliation":1341,"properties":20},{"id":1342,"createTime":1343,"updateTime":1343,"relativeEntities":1344,"slug":20,"properties":1345,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"cfc570f5-e516-433b-95fe-5621bf6af1cd","2024-01-11T23:40:48.872+00:00",[],{"title":1346},{"VI":1347},"State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Sichuan, China",{"title":1349},{"VI":1350},"Nongyun Wang",{"id":1352,"sortIndex":185,"researcher":20,"roles":1353,"affiliations":1354,"properties":1365},"8d86d4a5-3ad9-4af9-b2e3-99a70a09740b",[145],[1355],{"id":20,"sortIndex":21,"affiliation":1356,"properties":20},{"id":1357,"createTime":1358,"updateTime":1359,"relativeEntities":1360,"slug":1361,"properties":1362,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"17b97e5e-88d4-41c3-88b1-0a87455ae555","2023-12-23T21:59:36.563+00:00","2025-01-02T14:01:51.816+00:00",[],"Institute-of-Chinese-Materia-Medica-China-Academy-of-Chinese-Medical-Sciences-Beijing-China",{"title":1363},{"VI":1364},"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China",{"title":1366},{"VI":1367},"Bing Li",{"id":1369,"sortIndex":112,"researcher":20,"roles":1370,"affiliations":1371,"properties":1377},"e124df0e-ace9-48f3-b7aa-818292e74a8b",[145],[1372],{"id":20,"sortIndex":21,"affiliation":1373,"properties":20},{"id":1289,"createTime":1290,"updateTime":1291,"relativeEntities":1374,"slug":1293,"properties":1375,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1376},{"VI":1296},{"title":1378},{"VI":1379},"Qiong Liu",{"id":1381,"sortIndex":113,"researcher":20,"roles":1382,"affiliations":1383,"properties":1404},"7fe2cbec-bf1e-42c4-a67d-f3107e542d05",[145],[1384,1396],{"id":1385,"sortIndex":112,"affiliation":1386,"properties":1395},"91053fa5-98d3-4f67-b305-07e8a635ba20",{"id":1387,"createTime":1388,"updateTime":1389,"relativeEntities":1390,"slug":1391,"properties":1392,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"3c459a7e-a9a1-4488-a003-9a243a297951","2024-01-16T11:36:15.741+00:00","2024-09-23T22:37:20.484+00:00",[],"School-of-Chinese-Materia-Medica-Beijing-University-of-Chinese-Medicine-Beijing-China",{"title":1393},{"VI":1394},"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China",{},{"id":20,"sortIndex":21,"affiliation":1397,"properties":20},{"id":1398,"createTime":1399,"updateTime":1399,"relativeEntities":1400,"slug":20,"properties":1401,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"d16eb2b8-1b16-4956-8c07-2ef69a6aa86d","2024-01-11T23:40:48.884+00:00",[],{"title":1402},{"VI":1403},"National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China",{"title":1405},{"VI":1406},"Zhenquan Liu",{"url":1266,"publisher":1408,"properties":1436},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1409,"slug":10,"properties":1410,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1414,"manageAffiliations":1415,"indexDatabases":1416,"url":20,"thumbnailPath":20,"statistic":1431,"gsStatistic":20,"type":116,"analyzePriority":20},[],{"issn":1411,"title":1412,"url":1413},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1417,1424],{"id":72,"indexDatabase":1418,"url":20,"indexYears":20,"academicFieldIds":1423,"indexDatabaseRanking":20},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":1419,"label":1420,"description":1421,"key":83,"publicationTags":1422,"standard":20},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[88],{"id":90,"indexDatabase":1425,"url":103,"indexYears":104,"academicFieldIds":1430,"indexDatabaseRanking":20},{"id":92,"createTime":93,"updateTime":94,"relativeEntities":1426,"label":1427,"description":1428,"key":100,"publicationTags":1429,"standard":20},[],{"EN":97,"VI":97},{"EN":97,"VI":99},[102],[106,107,108],{"impactFactor":21,"impactFactorByYear":1432,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":58,"totalPublicationByYear":1433,"totalCitation":21,"totalCitationByYear":1434,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1435,"hindexLast5Year":21,"hindex":21},{},{"2002":112,"2024":113},{},{},{"volume":1437,"pages":1439},{"VOID":1438},"24",{"VOID":1440},"125-138","2021-06-12",2021,{"id":1444,"createTime":1445,"updateTime":1446,"relativeEntities":1447,"slug":1448,"properties":1449,"entityType":136,"verifyStatus":137,"verifyTime":1446,"verifyNote":138,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1458,"fullTextUrl":20,"authors":1459,"publicationType":233,"publisherRelationship":1487,"citationCount":20,"citationInfo":20,"publishDate":1521,"publishYear":1522,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":270},"49cdcd99-8820-4267-a480-8e1f00b2d1a2","2024-01-16T04:10:56.250+00:00","2025-01-29T23:40:46.381+00:00",[],"Tau-protein-in-familial-and-sporadic-diseases",{"references":1450,"abstract":1452,"title":1454,"doi":1456},{"VOID":1451},"Andreadis 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(1999) Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17. Proc. Natl. Acad. Sci. USA 96, 8229–8234.\nVerpillat P., Camuzat A., Hannequin D., et al. (2002) Association between the extended tau haplotype and frontotemporal dementia. Arch. Neurol. 59, 935–939.\nVon Bergen M., Barghorn S., Li L., et al. (2001) Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. J. Biol. Chem. 276, 48165–48174.\nYasuda M., Takamatsu J., D’Souza I., et al. (2000) A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto) Ann. Neurol. 47, 422–429.\nYoshida H., Crowther R. A., and Goedert M. (2002) Functional effects of tau gene mutations deltaN296 and N296H. J. Neurochem. 80, 548–551.\nZhukareva V., Sundarraj S., Mann D., et al. (2003) Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study. Acta. Neuropathol. (Berl.) 105, 469–476.",{"EN":1453},"Abnormal protein aggregation is a common characteristic of many neurodegenerative diseases of the brain. Filamentous deposits made of the microtubule-associated protein tau constitute a major defining characteristic of several neurodegenerative diseases known as tauopathies. The role of tau in neurodegeneration has been clarified by the identification of genetic mutations in the tau gene in cases with familial frontotemporal dementia and parkinsonism linked to chromosome 17. Furthermore, some sporadic tauopathies are associated with tau gene polymorphisms. Although it is still debated how tau gene mutations lead to neuronal death, it is clear that different mutations lead to tau pathologies with characteristics similar to those found in sporadic tauopathies. These findings have definitely shown that in tauopathies tau aggregation is directly associated with development of neurodegeneration and neuronal death.",{"EN":1455},"Tau protein in familial and sporadic diseases",{"VOID":1457},"10.1385\u002FNMM:4:1-2:37","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1385\u002FNMM:4:1-2:37",[1460,1475],{"id":1461,"sortIndex":112,"researcher":20,"roles":1462,"affiliations":1463,"properties":1472},"3d0f99f1-5457-4d06-9aed-afee94d60220",[145],[1464],{"id":20,"sortIndex":21,"affiliation":1465,"properties":20},{"id":1466,"createTime":1467,"updateTime":1467,"relativeEntities":1468,"slug":20,"properties":1469,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"4a47a815-b6d0-49e2-94ea-160d0c0ebcca","2024-01-16T04:10:56.274+00:00",[],{"title":1470},{"VI":1471},"Brain Repair Centre and Department of Neurology, University of Cambridge, Cambridge, UK",{"title":1473},{"VI":1474},"Maria Grazia Spillantini",{"id":1476,"sortIndex":21,"researcher":20,"roles":1477,"affiliations":1478,"properties":1484},"a58da0d6-604d-4720-b75f-3633200ddc49",[145],[1479],{"id":20,"sortIndex":21,"affiliation":1480,"properties":20},{"id":1466,"createTime":1467,"updateTime":1467,"relativeEntities":1481,"slug":20,"properties":1482,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1483},{"VI":1471},{"title":1485},{"VI":1486},"Despina Yancopoulou",{"url":1458,"publisher":1488,"properties":1516},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1489,"slug":10,"properties":1490,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1494,"manageAffiliations":1495,"indexDatabases":1496,"url":20,"thumbnailPath":20,"statistic":1511,"gsStatistic":20,"type":116,"analyzePriority":20},[],{"issn":1491,"title":1492,"url":1493},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1497,1504],{"id":72,"indexDatabase":1498,"url":20,"indexYears":20,"academicFieldIds":1503,"indexDatabaseRanking":20},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":1499,"label":1500,"description":1501,"key":83,"publicationTags":1502,"standard":20},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[88],{"id":90,"indexDatabase":1505,"url":103,"indexYears":104,"academicFieldIds":1510,"indexDatabaseRanking":20},{"id":92,"createTime":93,"updateTime":94,"relativeEntities":1506,"label":1507,"description":1508,"key":100,"publicationTags":1509,"standard":20},[],{"EN":97,"VI":97},{"EN":97,"VI":99},[102],[106,107,108],{"impactFactor":21,"impactFactorByYear":1512,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":58,"totalPublicationByYear":1513,"totalCitation":21,"totalCitationByYear":1514,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1515,"hindexLast5Year":21,"hindex":21},{},{"2002":112,"2024":113},{},{},{"volume":1517,"pages":1519},{"VOID":1518},"4",{"VOID":1520},"37-48","2003-10-01",2003,{"id":1524,"createTime":1525,"updateTime":1526,"relativeEntities":1527,"slug":1528,"properties":1529,"entityType":136,"verifyStatus":137,"verifyTime":1538,"verifyNote":138,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"primaryUrl":1539,"fullTextUrl":20,"authors":1540,"publicationType":233,"publisherRelationship":1656,"citationCount":20,"citationInfo":20,"publishDate":1689,"publishYear":269,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":270},"2419977e-29ff-497b-a04e-5c76c958308b","2024-01-10T15:55:24.526+00:00","2025-01-22T23:40:32.637+00:00",[],"GWAS-Supported-CRP-Gene-Polymorphisms-and-Functional-Outcome-of-Large-Artery-Atherosclerotic-Stroke-in-Han-Chinese",{"references":1530,"abstract":1532,"title":1534,"doi":1536},{"VOID":1531},"Adams, H. J., Bendixen, B. H., Kappelle, L. J., Biller, J., Love, B. B., et al. (1993). Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke, 24(1), 35–41.\nArenillas, J. F., Alvarez-Sabin, J., Molina, C. A., Chacon, P., Montaner, J., et al. (2003). C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. Stroke, 34(10), 2463–2468.\nBarrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2005). Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics, 21(2), 263–265.\nBiasucci, L. M., & C.D.C., & A.H.A. (2004). CDC\u002FAHA workshop on markers of inflammation and cardiovascular disease: Application to clinical and public health practice: Clinical use of inflammatory markers in patients with cardiovascular diseases: A background paper. Circulation, 110(25), e560–e567.\nBogaty, P., Brophy, J. M., Boyer, L., Simard, S., Joseph, L., et al. (2005). Fluctuating inflammatory markers in patients with stable ischemic heart disease. Archives of Internal Medicine, 165(2), 221–226.\nDeGraba, T. J. (1998). The role of inflammation after acute stroke: Utility of pursuing anti-adhesion molecule therapy. Neurology, 51(3), S62–S68.\nDehghan, A., Dupuis, J., Barbalic, M., Bis, J. C., Eiriksdottir, G., et al. (2011). Meta-analysis of genome-wide association studies in > 80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation, 123(7), 731–738.\nDeodhar, S. D. (1989). C-reactive protein: The best laboratory indicator available for monitoring disease activity. Cleveland Clinic Journal of Medicine, 56(2), 126–130.\nDi Napoli, M., Di PapaF, F., & Bocola, V. (2001). Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke. Stroke, 32(1), 133–138.\nDirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999). Pathobiology of ischaemic stroke: An integrated view. Trends in Neurosciences, 22(9), 391–397.\nDorajoo, R., Li, R., Ikram, M. K., Liu, J., Froguel, P., et al. (2013). Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? PLoS ONE, 8(7), e67650.\nGong, X., Zou, X., Liu, L., Pu, Y., Wang, Y., et al. (2013). Prognostic value of inflammatory mediators in 1-year outcome of acute ischemic stroke with middle cerebral artery stenosis. Mediators of Inflammation, 2013, 850714.\nGuo, J., Yu, L., Zhang, J., Chen, N., Zhou, M., & He, L. (2014). CRP gene polymorphism predicts post-stroke functional outcome in Han Chinese. Acta Neurologica Scandinavica, 129(4), 263–268.\nHuang, X., Wang, A., Liu, X., Chen, S., Zhu, Y., et al. (2016). Association between high sensitivity C-reactive protein and prevalence of asymptomatic carotid artery stenosis. Atherosclerosis, 246, 44–49.\nKaptoge, S., Di Angelantonio, E., Lowe, G., Pepys, M. B., Thompson, S. G., et al. (2010). C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis. Lancet, 375(9709), 132–140.\nKivimaki, M., Lawlor, D. A., Juonala, M., Smith, G. D., Elovainio, M., et al. (2005). Lifecourse socioeconomic position, C-reactive protein, and carotid intima-media thickness in young adults: The cardiovascular risk in Young Finns Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(10), 2197–2202.\nKivimaki, M., Lawlor, D. A., Smith, G. D., Eklund, C., Hurme, M., et al. (2007). Variants in the CRP gene as a measure of lifelong differences in average C-reactive protein levels: The Cardiovascular Risk in Young Finns Study, 1980–2001. American Journal of Epidemiology, 166(7), 760–764.\nKong, H., Qian, Y. S., Tang, X. F., Zhang, J., Gao, P. J., et al. (2012). C-reactive protein (CRP) gene polymorphisms CRP levels and risk of incident essential hypertension: Findings from an observational cohort of Han Chinese. Hypertension Research, 35(10), 1019–1023.\nKotlega, D., Nowacki, P., Bialecka, M., Kurzawski, M., Drozdzik, M., & Ciecwiez, S. (2014). Association between CRP gene polymorphism 717A\u002FG, C-reactive protein and neurological deficit in ischemic stroke. Journal of Clinical Neuroscience, 21(4), 574–577.\nKushner, I., Rzewnicki, D., & Samols, D. (2006). What does minor elevation of C-reactive protein signify? American Journal of Medicine, 119(2), 117–166.\nLadenvall, C., Jood, K., Blomstrand, C., Nilsson, S., Jern, C., & Ladenvall, P. (2006). Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. Stroke, 37(8), 2018–2023.\nLiu, X., Xu, G., Wu, W., Zhang, R., Yin, Q., & Zhu, W. (2006). Subtypes and one-year survival of first-ever stroke in Chinese patients: The Nanjing Stroke Registry. Cerebrovascular Diseases, 22(2–3), 130–136.\nMontero-Vega, M. T. (2012). The inflammatory process underlying atherosclerosis. Critical Reviews in Immunology, 32(5), 373–462.\nOkada, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Kamatani, Y., et al. (2011). Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Human Molecular Genetics, 20(6), 1224–1231.\nPandey, A., Shrivastava, A. K., & Saxena, K. (2014). Neuron specific enolase and C-reactive protein levels in stroke and its subtypes: Correlation with degree of disability. Neurochemical Research, 39(8), 1426–1432.\nRajeshwar, K., Kaul, S., Al-Hazzani, A., Babu, M. S., Balakrishna, N., et al. (2012). C-reactive protein and nitric oxide levels in ischemic stroke and its subtypes: Correlation with clinical outcome. Inflammation, 35(3), 978–984.\nReiner, A. P., Beleza, S., Franceschini, N., Auer, P. L., Robinson, J. G., et al. (2012). Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. American Journal of Human Genetics, 91(3), 502–512.\nRyu, S. R., Choi, I. S., Bian, R. X., Kim, J. H., Han, J. Y., & Lee, S. G. (2009). The effect of C-reactive protein on functional outcome in ischemic stroke patients. International Journal of Neuroscience, 119(3), 336–344.\nShen, C., Sun, X., Wang, H., Wang, B., Xue, Y., et al. (2014). Association study of CRP gene and ischemic stroke in a Chinese Han population. Journal of Molecular Neuroscience, 49(3), 559–566.\nSolé, X., Guinó, E., Valls, J., Iniesta, R., & Moreno, V. (2006). SNPStats: A web tool for the analysis of association studies. Bioinformatics, 22(15), 1928–1929.\nSong, I. U., Kim, J. S., Kim, Y. I., Lee, K. S., Jeong, D. S., & Chung, S. W. (2009). Relationship between high-sensitivity C-reactive protein and clinical functional outcome after acute ischemic stroke in a Korean population. Cerebrovascular Diseases, 28(6), 545–550.\nTuttolomondo, A., Di Raimondo, D., Pecoraro, R., Arnao, V., Pinto, A., & Licata, G. (2012). Atherosclerosis as an inflammatory disease. Current Pharmaceutical Design, 18(28), 4266–4288.\nVinayagamoorthy, N., Hu, H. J., Yim, S. H., Jung, S. H., Jo, J., et al. (2014). New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. PLoS ONE, 9(4), e95866.\nWinbeck, K., Poppert, H., Etgen, T., Conrad, B., & Sander, D. (2002). Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke. Stroke, 33(10), 2459–2464.\nWu, Y., McDade, T. W., Kuzawa, C. W., Borja, J., Li, Y., et al. (2012). Genome-wide association with C-reactive protein levels in CLHNS: Evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. Inflammation, 35(3), 574–583.\nXue, Y., Zhang, L., Fan, Y., Li, Q., Jiang, Y., et al. (2017). C-reactive protein gene contributes to the genetic susceptibility of hemorrhagic stroke in men: A case-control study in Chinese han population. Journal of Molecular Neuroscience, 62(3–4), 395–401.\nYe, Z., Zhang, Z., Zhang, H., Hao, Y., Zhang, J., et al. (2017). Prognostic value of C-reactive protein and homocysteine in large-artery atherosclerotic stroke: A prospective observational study. Journal of Stroke and Cerebrovascular Diseases, 26(3), 618–626.\nYeh, K. H., Tsai, T. H., Chai, H. T., Leu, S., Chung, S. Y., et al. (2012). Comparison of acute versus convalescent stage high-sensitivity C-Reactive protein level in predicting clinical outcome after acute ischemic stroke and impact of erythropoietin. Journal of Translational Medicine, 10, 6.",{"EN":1533},"Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with first-ever LAA IS were prospectively enrolled in Nanjing Stroke Registry Program between August 2013 and October 2015. Five single-nucleotide polymorphisms (SNPs) (rs876537, rs2794520, rs3093059, rs7553007 and rs11265260) in CRP gene related to CRP levels in Asian by genome-wide association study were genotyped. The functional outcome at 3 months after the index stroke was assessed by the modified Rankin scale. Associations between genotypes and functional outcome of LAA IS were analyzed with logistic regression model. A total of 690 eligible patients (507 males) were evaluated. SNPs rs11265260 (multivariate-adjusted, p = 0.022), rs2794520 (multivariate-adjusted, p = 0.036) and rs3093059 (multivariate-adjusted, p = 0.027) were significantly associated with elevated CRP in acute IS. Two SNPs, rs3093059 (dominant model: adjusted OR 2.49; 95% CI 1.55–4.00; recessive model: adjusted OR 3.67; 95% CI 1.22–11.03) and rs11265260 (dominant model: adjusted OR 2.51; 95% CI 1.56–4.02; recessive model: adjusted OR 4.70; 95% CI 1.63–13.56) independently predicted 3-month poor outcome of first-ever LAA IS, after adjusting for covariates. In addition, haplotype analysis indicated that haplotype GCTGC (adjusted OR 1.76; 95% CI 1.05–2.95; p = 0.031) increased the poor outcome risk. SNPs rs3093059 and rs11265260 in CRP gene may influence the 3-month functional outcome of first-ever LAA IS in Han Chinese.",{"EN":1535},"GWAS-Supported CRP Gene Polymorphisms and Functional Outcome of Large Artery Atherosclerotic Stroke in Han Chinese",{"VOID":1537},"10.1007\u002Fs12017-018-8485-y","2025-01-22T23:40:32.636+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12017-018-8485-y",[1541,1556,1568,1592,1604,1616,1632,1644],{"id":1542,"sortIndex":113,"researcher":20,"roles":1543,"affiliations":1544,"properties":1553},"f18acee4-b315-4e1b-8733-6bf7a47d5eb9",[145],[1545],{"id":20,"sortIndex":21,"affiliation":1546,"properties":20},{"id":1547,"createTime":1548,"updateTime":1548,"relativeEntities":1549,"slug":20,"properties":1550,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"69607815-e387-40e0-aa2e-ee7d1fd3442b","2024-02-06T08:10:32.347+00:00",[],{"title":1551},{"VI":1552},"Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China",{"title":1554},{"VI":1555},"Zhizhong Zhang",{"id":1557,"sortIndex":58,"researcher":20,"roles":1558,"affiliations":1559,"properties":1565},"145f2327-c4ef-4f6d-948e-43ca0c5c6513",[145],[1560],{"id":20,"sortIndex":21,"affiliation":1561,"properties":20},{"id":1547,"createTime":1548,"updateTime":1548,"relativeEntities":1562,"slug":20,"properties":1563,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1564},{"VI":1552},{"title":1566},{"VI":1567},"Xinfeng Liu",{"id":1569,"sortIndex":21,"researcher":20,"roles":1570,"affiliations":1571,"properties":1589},"779243a2-5d2a-4fd6-91ae-05fdf1d5b5b0",[145],[1572,1584],{"id":1573,"sortIndex":112,"affiliation":1574,"properties":1583},"66afede4-28ef-419d-b8e7-02a27ce28060",{"id":1575,"createTime":1576,"updateTime":1577,"relativeEntities":1578,"slug":1579,"properties":1580,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"87928d36-c169-47b9-82a2-c8c9ae908e75","2024-02-16T22:37:40.705+00:00","2024-09-25T21:03:15.408+00:00",[],"Department-of-Neurology-The-First-Affiliated-Hospital-of-Wenzhou-Medical-University-Wenzhou-China",{"title":1581},{"VI":1582},"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China",{},{"id":20,"sortIndex":21,"affiliation":1585,"properties":20},{"id":1547,"createTime":1548,"updateTime":1548,"relativeEntities":1586,"slug":20,"properties":1587,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1588},{"VI":1552},{"title":1590},{"VI":1591},"Zusen Ye",{"id":1593,"sortIndex":143,"researcher":20,"roles":1594,"affiliations":1595,"properties":1601},"238ce013-86df-475d-984a-273eecff4e3e",[145],[1596],{"id":20,"sortIndex":21,"affiliation":1597,"properties":20},{"id":1547,"createTime":1548,"updateTime":1548,"relativeEntities":1598,"slug":20,"properties":1599,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1600},{"VI":1552},{"title":1602},{"VI":1603},"Huan Cai",{"id":1605,"sortIndex":162,"researcher":20,"roles":1606,"affiliations":1607,"properties":1613},"5396516d-b244-4bf1-93fd-12f1a5ecd933",[145],[1608],{"id":20,"sortIndex":21,"affiliation":1609,"properties":20},{"id":1547,"createTime":1548,"updateTime":1548,"relativeEntities":1610,"slug":20,"properties":1611,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1612},{"VI":1552},{"title":1614},{"VI":1615},"Zongliang Xu",{"id":1617,"sortIndex":112,"researcher":20,"roles":1618,"affiliations":1619,"properties":1629},"e517f1c9-fa82-4020-9deb-34e6d6477f48",[145],[1620],{"id":20,"sortIndex":21,"affiliation":1621,"properties":20},{"id":1622,"createTime":1623,"updateTime":1623,"relativeEntities":1624,"slug":1625,"properties":1626,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"52975473-6289-4e61-84c2-d99f853b454e","2024-04-16T13:09:50.155+00:00",[],"Department-of-Neurology-Jinling-Hospital-Medical-School-of-Nanjing-University-Nanjing-China",{"title":1627},{"EN":1628},"Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China",{"title":1630},{"VI":1631},"Hao Zhang",{"id":1633,"sortIndex":185,"researcher":20,"roles":1634,"affiliations":1635,"properties":1641},"aabdadca-8acc-4a68-a103-b5f50da2f337",[145],[1636],{"id":20,"sortIndex":21,"affiliation":1637,"properties":20},{"id":1547,"createTime":1548,"updateTime":1548,"relativeEntities":1638,"slug":20,"properties":1639,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1640},{"VI":1552},{"title":1642},{"VI":1643},"Yonggang Hao",{"id":1645,"sortIndex":210,"researcher":20,"roles":1646,"affiliations":1647,"properties":1653},"f70160cc-358f-4225-a64a-2e8be160d25a",[145],[1648],{"id":20,"sortIndex":21,"affiliation":1649,"properties":20},{"id":1622,"createTime":1623,"updateTime":1623,"relativeEntities":1650,"slug":1625,"properties":1651,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1652},{"EN":1628},{"title":1654},{"VI":1655},"Lingli Sun",{"url":1539,"publisher":1657,"properties":1685},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1658,"slug":10,"properties":1659,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1663,"manageAffiliations":1664,"indexDatabases":1665,"url":20,"thumbnailPath":20,"statistic":1680,"gsStatistic":20,"type":116,"analyzePriority":20},[],{"issn":1660,"title":1661,"url":1662},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1666,1673],{"id":72,"indexDatabase":1667,"url":20,"indexYears":20,"academicFieldIds":1672,"indexDatabaseRanking":20},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":1668,"label":1669,"description":1670,"key":83,"publicationTags":1671,"standard":20},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[88],{"id":90,"indexDatabase":1674,"url":103,"indexYears":104,"academicFieldIds":1679,"indexDatabaseRanking":20},{"id":92,"createTime":93,"updateTime":94,"relativeEntities":1675,"label":1676,"description":1677,"key":100,"publicationTags":1678,"standard":20},[],{"EN":97,"VI":97},{"EN":97,"VI":99},[102],[106,107,108],{"impactFactor":21,"impactFactorByYear":1681,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":58,"totalPublicationByYear":1682,"totalCitation":21,"totalCitationByYear":1683,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1684,"hindexLast5Year":21,"hindex":21},{},{"2002":112,"2024":113},{},{},{"volume":1686,"pages":1687},{"VOID":265},{"VOID":1688},"225-232","2018-03-19",{"id":1691,"createTime":1692,"updateTime":1693,"relativeEntities":1694,"slug":1695,"properties":1696,"entityType":136,"verifyStatus":137,"verifyTime":1693,"verifyNote":138,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":210,"primaryUrl":1705,"fullTextUrl":20,"authors":1706,"publicationType":233,"publisherRelationship":1770,"citationCount":20,"citationInfo":20,"publishDate":1803,"publishYear":903,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":20,"openAccess":20,"references":20,"isForceReanalyzing":270},"3eab987b-e421-4845-b379-6fc8bac14865","2023-12-14T08:42:11.192+00:00","2025-02-23T23:37:11.026+00:00",[],"AMPA-Receptor-Properties-are-Modulated-in-the-Early-Stages-Following-Pilocarpine-induced-Status-Epilepticus",{"references":1697,"abstract":1699,"title":1701,"doi":1703},{"VOID":1698},"Amaral, D. 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Patterns of hippocampal neuronal loss and axon reorganization of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy. Journal of Neuroscience Research, 87, 1135–1149.\nZhang, G., Raol, Y. S., Hsu, F. C., & Brooks-Kayal, A. R. (2004). Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. Journal of Neurochemistry, 88, 91–101.",{"EN":1700},"Glutamate over-activation and the consequent neuronal excitotoxicity have been identified as crucial players in brain dysfunctions such as status epilepticus (SE). Owing to the central function of 2-amino-3-(hydroxyl-5-methylisoxazole-4-yl) propionic acid receptors (AMPARs) in fast excitatory neurotransmission, these receptors have been recognized to play a prominent role in the development and generation of epileptic seizure. This study was undertaken to investigate both the early changes that affect glutamatergic neurons in the rat cerebral cortex and hippocampus and the level and channel properties of AMPARs in response to SE. The results obtained after 3 h of pilocarpine (PILO)-induced SE showed a disorganization of glutamatergic neurons in the CA3 and a thinner neuronal cell layer in the dentate gyrus (DG) region as compared with controls. A significant increase in AMPAR GluA2 protein expression, a decrease in GluA1, GluA3, and GluA4 expression, and a reduction in the phosphorylation of Ser831-GluA1 and Ser880-GluA2 were also observed. In addition, we report a downregulation of R\u002FG editing levels and of Flip splicing isoforms, with a prominent effect on the hippocampus of PILO-treated rats. Our results suggest the presence of an attenuation of AMPARs’ post-synaptic excitatory response to glutamate after PILO treatment, thus conferring neuronal protection from the excitotoxic conditions observed in the SE. This study suggests a role for AMPARs in alterations of the glutamatergic pathway during the onset and early progression of epilepsy, thus indicating additional targets for potential therapeutic interventions.",{"EN":1702},"AMPA Receptor Properties are Modulated in the Early Stages Following Pilocarpine-induced Status Epilepticus",{"VOID":1704},"10.1007\u002Fs12017-013-8221-6","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs12017-013-8221-6",[1707,1722,1734,1746,1758],{"id":1708,"sortIndex":112,"researcher":20,"roles":1709,"affiliations":1710,"properties":1719},"5462711a-e956-48ba-af9f-7692e1a0e755",[145],[1711],{"id":20,"sortIndex":21,"affiliation":1712,"properties":20},{"id":1713,"createTime":1714,"updateTime":1714,"relativeEntities":1715,"slug":20,"properties":1716,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},"515a2db5-0be2-476e-b0ea-e05b0da09a39","2023-12-14T08:42:11.245+00:00",[],{"title":1717},{"VI":1718},"Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology and National Institute of Neuroscience, University of Brescia, Brescia, Italy",{"title":1720},{"VI":1721},"Daniela Bonini",{"id":1723,"sortIndex":185,"researcher":20,"roles":1724,"affiliations":1725,"properties":1731},"e4c835ed-dc2a-4b29-a804-c5171ba2df0d",[145],[1726],{"id":20,"sortIndex":21,"affiliation":1727,"properties":20},{"id":1713,"createTime":1714,"updateTime":1714,"relativeEntities":1728,"slug":20,"properties":1729,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1730},{"VI":1718},{"title":1732},{"VI":1733},"Alessandro Barbon",{"id":1735,"sortIndex":143,"researcher":20,"roles":1736,"affiliations":1737,"properties":1743},"87245a15-014d-4b9d-919d-8ca72907ca7e",[145],[1738],{"id":20,"sortIndex":21,"affiliation":1739,"properties":20},{"id":1713,"createTime":1714,"updateTime":1714,"relativeEntities":1740,"slug":20,"properties":1741,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1742},{"VI":1718},{"title":1744},{"VI":1745},"Sergio Barlati",{"id":1747,"sortIndex":21,"researcher":20,"roles":1748,"affiliations":1749,"properties":1755},"5c06f711-4a97-4b2d-99d8-9d1c2a15cd0e",[145],[1750],{"id":20,"sortIndex":21,"affiliation":1751,"properties":20},{"id":1713,"createTime":1714,"updateTime":1714,"relativeEntities":1752,"slug":20,"properties":1753,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1754},{"VI":1718},{"title":1756},{"VI":1757},"Isabella Russo",{"id":1759,"sortIndex":210,"researcher":20,"roles":1760,"affiliations":1761,"properties":1767},"1a2c540f-41bc-4a83-a752-9d2f42aa2c8d",[145],[1762],{"id":20,"sortIndex":21,"affiliation":1763,"properties":20},{"id":1713,"createTime":1714,"updateTime":1714,"relativeEntities":1764,"slug":20,"properties":1765,"entityType":57,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21},[],{"title":1766},{"VI":1718},{"title":1768},{"VI":1769},"Luca La Via",{"url":1705,"publisher":1771,"properties":1799},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1772,"slug":10,"properties":1773,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"syncStatus":19,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":1777,"manageAffiliations":1778,"indexDatabases":1779,"url":20,"thumbnailPath":20,"statistic":1794,"gsStatistic":20,"type":116,"analyzePriority":20},[],{"issn":1774,"title":1775,"url":1776},{"VOID":13},{"EN":15},{"VOID":17},[],[],[1780,1787],{"id":72,"indexDatabase":1781,"url":20,"indexYears":20,"academicFieldIds":1786,"indexDatabaseRanking":20},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":1782,"label":1783,"description":1784,"key":83,"publicationTags":1785,"standard":20},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[88],{"id":90,"indexDatabase":1788,"url":103,"indexYears":104,"academicFieldIds":1793,"indexDatabaseRanking":20},{"id":92,"createTime":93,"updateTime":94,"relativeEntities":1789,"label":1790,"description":1791,"key":100,"publicationTags":1792,"standard":20},[],{"EN":97,"VI":97},{"EN":97,"VI":99},[102],[106,107,108],{"impactFactor":21,"impactFactorByYear":1795,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":58,"totalPublicationByYear":1796,"totalCitation":21,"totalCitationByYear":1797,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":1798,"hindexLast5Year":21,"hindex":21},{},{"2002":112,"2024":113},{},{},{"volume":1800,"pages":1801},{"VOID":899},{"VOID":1802},"324-338","2013-03-15"]