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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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Cell; citation_title=Deregulated expression of mammalian lncRNA through loss of SPT6 induces R-loop formation, replication stress, and cellular senescence; citation_author=T Nojima; citation_volume=72; citation_publication_date=2018; citation_pages=970-984.e7; citation_id=CR15",{"id":28,"text":1154,"url":28,"identifiers":28},"citation_journal_title=RNA; citation_title=Predictive models of subcellular localization of long RNAs; citation_author=B Zuckerman, I Ulitsky; citation_volume=25; citation_publication_date=2019; citation_pages=557-572; citation_id=CR16",{"id":28,"text":1156,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Learning the sequence determinants of alternative splicing from millions of random sequences; citation_author=AB Rosenberg, RP Patwardhan, J Shendure, G Seelig; citation_volume=163; citation_publication_date=2015; citation_pages=698-711; citation_id=CR17",{"id":28,"text":1158,"url":28,"identifiers":28},"citation_journal_title=Cell Res.; citation_title=Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus; citation_author=JF Xiang; citation_volume=24; citation_publication_date=2014; citation_pages=513-531; citation_id=CR18",{"id":28,"text":1160,"url":28,"identifiers":28},"citation_journal_title=RNA Biol.; citation_title=Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus; citation_author=S Azam; citation_volume=16; citation_publication_date=2019; citation_pages=1001-1009; citation_id=CR19",{"id":28,"text":1162,"url":28,"identifiers":28},"citation_journal_title=EMBO J.; citation_title=High-throughput identification of RNA nuclear enrichment sequences; citation_author=CJ Shukla; citation_volume=37; citation_publication_date=2018; citation_id=CR20",{"id":28,"text":1164,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells; citation_author=Y Lubelsky, I Ulitsky; citation_volume=555; citation_publication_date=2018; citation_pages=107-111; citation_id=CR21",{"id":28,"text":1166,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=Function and evolution of local repeats in the Firre locus; citation_author=E Hacisuleyman, CJ Shukla, CL Weiner, JL Rinn; citation_volume=7; citation_publication_date=2016; citation_id=CR22",{"id":28,"text":1168,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Gene architecture and sequence composition underpin selective dependency of nuclear export of long RNAs on NXF1 and the TREX complex; citation_author=B Zuckerman, M Ron, M Mikl, E Segal, I Ulitsky; citation_volume=79; citation_publication_date=2020; citation_pages=251-267; citation_id=CR23",{"id":28,"text":1170,"url":28,"identifiers":28},"citation_journal_title=RNA; citation_title=Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells; citation_author=J Carlevaro-Fita, A Rahim, R Guigo, LA Vardy, R Johnson; citation_volume=22; citation_publication_date=2016; citation_pages=867-882; citation_id=CR24",{"id":28,"text":1172,"url":28,"identifiers":28},"citation_journal_title=BMC Genomics; citation_title=Identifying sequence features that drive ribosomal association for lncRNA; citation_author=C Zeng, M Hamada; citation_volume=19; citation_publication_date=2018; citation_id=CR25",{"id":28,"text":1174,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=The human mitochondrial transcriptome; citation_author=TR Mercer; citation_volume=146; citation_publication_date=2011; citation_pages=645-658; citation_id=CR26",{"id":28,"text":1176,"url":28,"identifiers":28},"citation_journal_title=RNA; citation_title=Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins; citation_author=O Rackham; citation_volume=17; citation_publication_date=2011; citation_pages=2085-2093; citation_id=CR27",{"id":28,"text":1178,"url":28,"identifiers":28},"citation_journal_title=Genes Dev.; citation_title=HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP; citation_author=JH Noh; citation_volume=30; citation_publication_date=2016; citation_pages=1224-1239; citation_id=CR28",{"id":28,"text":1180,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Res.; citation_title=exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes; citation_author=S Li; citation_volume=46; citation_publication_date=2018; citation_pages=D106-D112; citation_id=CR29",{"id":28,"text":1182,"url":28,"identifiers":28},"citation_journal_title=Sci. Rep.; citation_title=Prediction of lncRNA subcellular localization with deep learning from sequence features; citation_author=BL Gudenas, L Wang; citation_volume=8; citation_publication_date=2018; citation_id=CR30",{"id":28,"text":1184,"url":28,"identifiers":28},"citation_journal_title=PLoS ONE; citation_title=Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes; citation_author=L Statello; citation_volume=13; citation_publication_date=2018; citation_id=CR31",{"id":28,"text":1186,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Genomic maps of long noncoding RNA occupancy reveal principles of RNA–chromatin interactions; citation_author=C Chu, K Qu, FL Zhong, SE Artandi, HY Chang; citation_volume=44; citation_publication_date=2011; citation_pages=667-678; citation_id=CR32",{"id":28,"text":1188,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=RADICL-seq identifies general and cell type-specific principles of genome-wide RNA–chromatin interactions; citation_author=A Bonetti; citation_volume=11; citation_publication_date=2020; citation_id=CR33",{"id":28,"text":1190,"url":28,"identifiers":28},"citation_journal_title=Nat. Biotechnol.; citation_title=GRID-seq reveals the global RNA–chromatin interactome; citation_author=X Li; citation_volume=35; citation_publication_date=2017; citation_pages=940-950; citation_id=CR34",{"id":28,"text":1192,"url":28,"identifiers":28},"citation_journal_title=eLife; citation_title=Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts; citation_author=JC Bell; citation_volume=7; citation_publication_date=2018; citation_id=CR35",{"id":28,"text":1194,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Non-coding transcription instructs chromatin folding and compartmentalization to dictate enhancer–promoter communication and T cell fate; citation_author=T Isoda; citation_volume=171; citation_publication_date=2017; citation_pages=103-119.e18; citation_id=CR36",{"id":28,"text":1196,"url":28,"identifiers":28},"citation_journal_title=Nat. Methods; citation_title=HiChIRP reveals RNA-associated chromosome conformation; citation_author=MR Mumbach; citation_volume=16; citation_publication_date=2019; citation_pages=489-492; citation_id=CR37",{"id":28,"text":1198,"url":28,"identifiers":28},"citation_journal_title=Cell Chem. Biol.; citation_title=Neutralization of the positive charges on histone tails by RNA promotes an open chromatin structure; citation_author=R Dueva; citation_volume=26; citation_publication_date=2019; citation_pages=1436-1449.e5; citation_id=CR38",{"id":28,"text":1200,"url":28,"identifiers":28},"citation_journal_title=Genome Biol.; citation_title=The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation; citation_author=F Yang; citation_volume=16; citation_publication_date=2015; citation_id=CR39",{"id":28,"text":1202,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=RNA interactions are essential for CTCF-mediated genome organization; citation_author=R Saldana-Meyer; citation_volume=76; citation_publication_date=2019; citation_pages=412-422.e5; citation_id=CR40",{"id":28,"text":1204,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=lncRNA-induced spread of polycomb controlled by genome architecture, RNA abundance, and CpG island DNA; citation_author=MD Schertzer; citation_volume=75; citation_publication_date=2019; citation_pages=523-537.e10; citation_id=CR41",{"id":28,"text":1206,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=The long non-coding RNA morrbid regulates Bim and short-lived myeloid cell lifespan; citation_author=JJ Kotzin; citation_volume=537; citation_publication_date=2016; citation_pages=239-243; citation_id=CR42",{"id":28,"text":1208,"url":28,"identifiers":28},"citation_journal_title=PLoS Genet.; citation_title=The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation; citation_author=FC Beckedorff; citation_volume=9; citation_publication_date=2013; citation_id=CR43",{"id":28,"text":1210,"url":28,"identifiers":28},"citation_journal_title=Genome Biol.; citation_title=The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element; citation_author=O Marin-Bejar; citation_volume=18; citation_publication_date=2017; citation_id=CR44",{"id":28,"text":1212,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a; citation_author=KL Yap; citation_volume=38; citation_publication_date=2010; citation_pages=662-674; citation_id=CR45",{"id":28,"text":1214,"url":28,"identifiers":28},"citation_journal_title=PLoS Genet.; citation_title=Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks; citation_author=LM Holdt; citation_volume=9; citation_publication_date=2013; citation_id=CR46",{"id":28,"text":1216,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells; citation_author=Y Long; citation_volume=52; citation_publication_date=2020; citation_pages=931-938; citation_id=CR47",{"id":28,"text":1218,"url":28,"identifiers":28},"citation_journal_title=EMBO J.; citation_title=Re-evaluating the foundations of lncRNA–Polycomb function; citation_author=MR Blanco, M Guttman; citation_volume=36; citation_publication_date=2017; citation_pages=964-966; citation_id=CR48",{"id":28,"text":1220,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Functional classification and experimental dissection of long noncoding RNAs; citation_author=F Kopp, JT Mendell; citation_volume=172; citation_publication_date=2018; citation_pages=393-407; citation_id=CR49",{"id":28,"text":1222,"url":28,"identifiers":28},"citation_journal_title=EMBO J.; citation_title=PRC2 is dispensable for HOTAIR-mediated transcriptional repression; citation_author=M Portoso; citation_volume=36; citation_publication_date=2017; citation_pages=981-994; citation_id=CR50",{"id":28,"text":1224,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs; citation_author=JL Rinn; citation_volume=129; citation_publication_date=2007; citation_pages=1311-1323; citation_id=CR51",{"id":28,"text":1226,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=X-inactivation, imprinting, and long noncoding RNAs in health and disease; citation_author=JT Lee, MS Bartolomei; citation_volume=152; citation_publication_date=2013; citation_pages=1308-1323; citation_id=CR52",{"id":28,"text":1228,"url":28,"identifiers":28},"citation_journal_title=Science; citation_title=Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing; citation_author=PA Latos; citation_volume=338; citation_publication_date=2012; citation_pages=1469-1472; citation_id=CR53",{"id":28,"text":1230,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation; citation_author=RR Pandey; citation_volume=32; citation_publication_date=2008; citation_pages=232-246; citation_id=CR54",{"id":28,"text":1232,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=hnRNPK recruits PCGF3\u002F5-PRC1 to the Xist RNA B-repeat to establish Polycomb-mediated chromosomal silencing; citation_author=G Pintacuda; citation_volume=68; citation_publication_date=2017; citation_pages=955-969.e10; citation_id=CR55",{"id":28,"text":1234,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Xist deletional analysis reveals an interdependency between Xist RNA and Polycomb complexes for spreading along the inactive X; citation_author=D Colognori, H Sunwoo, AJ Kriz, CY Wang, JT Lee; citation_volume=74; citation_publication_date=2019; citation_pages=101-117.e10; citation_id=CR56",{"id":28,"text":1236,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3; citation_author=CA McHugh; citation_volume=521; citation_publication_date=2015; citation_pages=232-236; citation_id=CR57",{"id":28,"text":1238,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=YY1 tethers Xist RNA to the inactive X nucleation center; citation_author=Y Jeon, JT Lee; citation_volume=146; citation_publication_date=2011; citation_pages=119-133; citation_id=CR58",{"id":28,"text":1240,"url":28,"identifiers":28},"citation_journal_title=Science; citation_title=Transcription factor trapping by RNA in gene regulatory elements; citation_author=AA Sigova; citation_volume=350; citation_publication_date=2015; citation_pages=978-981; citation_id=CR59",{"id":28,"text":1242,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments; citation_author=S Fanucchi; citation_volume=51; citation_publication_date=2019; citation_pages=138-150; citation_id=CR60",{"id":28,"text":1244,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression; citation_author=KC Wang; citation_volume=472; citation_publication_date=2011; citation_pages=120-124; citation_id=CR61",{"id":28,"text":1246,"url":28,"identifiers":28},"citation_journal_title=Cancer Cell; citation_title=HOTTIP lncRNA promotes hematopoietic stem cell self-renewal leading to AML-like disease in mice; citation_author=H Luo; citation_volume=36; citation_publication_date=2019; citation_pages=645-659.e8; citation_id=CR62",{"id":28,"text":1248,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=lncPRESS1 is a p53-regulated lncRNA that safeguards pluripotency by disrupting SIRT6-mediated de-acetylation of histone H3K56; citation_author=AK Jain; citation_volume=64; citation_publication_date=2016; citation_pages=967-981; citation_id=CR63",{"id":28,"text":1250,"url":28,"identifiers":28},"citation_journal_title=Genes Dev.; citation_title=Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes; citation_author=KM Schmitz, C Mayer, A Postepska, I Grummt; citation_volume=24; citation_publication_date=2010; citation_pages=2264-2269; citation_id=CR64",{"id":28,"text":1252,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript; citation_author=I Martianov, A Ramadass, A Serra Barros, N Chow, A Akoulitchev; citation_volume=445; citation_publication_date=2007; citation_pages=666-670; citation_id=CR65",{"id":28,"text":1254,"url":28,"identifiers":28},"citation_journal_title=Cell Rep.; citation_title=PARTICLE, a triplex-forming long ncRNA, regulates locus-specific methylation in response to low-dose irradiation; citation_author=VB O’Leary; citation_volume=11; citation_publication_date=2015; citation_pages=474-485; citation_id=CR66",{"id":28,"text":1256,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures; citation_author=T Mondal; citation_volume=6; citation_publication_date=2015; citation_id=CR67",{"id":28,"text":1258,"url":28,"identifiers":28},"citation_journal_title=Dev. Cell; citation_title=The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse; citation_author=P Grote; citation_volume=24; citation_publication_date=2013; citation_pages=206-214; citation_id=CR68",{"id":28,"text":1260,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Res.; citation_title=Detection of RNA–DNA binding sites in long noncoding RNAs; citation_author=CC Kuo; citation_volume=47; citation_publication_date=2019; citation_id=CR69",{"id":28,"text":1262,"url":28,"identifiers":28},"citation_journal_title=Cell Chem. Biol.; citation_title=RNA–DNA triplex formation by long noncoding RNAs; citation_author=Y Li, J Syed, H Sugiyama; citation_volume=23; citation_publication_date=2016; citation_pages=1325-1333; citation_id=CR70",{"id":28,"text":1264,"url":28,"identifiers":28},"citation_journal_title=Cell Rep.; citation_title=lncRNA KHPS1 activates a poised enhancer by triplex-dependent recruitment of epigenomic regulators; citation_author=A Blank-Giwojna, A Postepska-Igielska, I Grummt; citation_volume=26; citation_publication_date=2019; citation_pages=2904-2915.e4; citation_id=CR71",{"id":28,"text":1266,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Nucleosomes stabilize ssRNA–dsDNA triple helices in human cells; citation_author=R Maldonado, U Schwartz, E Silberhorn, G Langst; citation_volume=73; citation_publication_date=2019; citation_pages=1243-1254.e6; citation_id=CR72",{"id":28,"text":1268,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=lncRNA Khps1 regulates expression of the proto-oncogene SPHK1 via triplex-mediated changes in chromatin structure; citation_author=A Postepska-Igielska; citation_volume=60; citation_publication_date=2015; citation_pages=626-636; citation_id=CR73",{"id":28,"text":1270,"url":28,"identifiers":28},"citation_journal_title=Nat. Rev. Mol. Cell Biol.; citation_title=Regulatory R-loops as facilitators of gene expression and genome stability; citation_author=C Niehrs, B Luke; citation_volume=21; citation_publication_date=2020; citation_pages=167-178; citation_id=CR74",{"id":28,"text":1272,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=R-loops promote antisense transcription across the mammalian genome; citation_author=SM Tan-Wong, S Dhir, NJ Proudfoot; citation_volume=76; citation_publication_date=2019; citation_pages=600-616.e6; citation_id=CR75",{"id":28,"text":1274,"url":28,"identifiers":28},"citation_journal_title=Science; citation_title=R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus; citation_author=Q Sun, T Csorba, K Skourti-Stathaki, NJ Proudfoot, C Dean; citation_volume=340; citation_publication_date=2013; citation_pages=619-621; citation_id=CR76",{"id":28,"text":1276,"url":28,"identifiers":28},"citation_journal_title=Front. Immunol.; citation_title=Divergent lncRNA GATA3-AS1 regulates GATA3 transcription in T-helper 2 cells; citation_author=HR Gibbons; citation_volume=9; citation_publication_date=2018; citation_pages=2512; citation_id=CR77",{"id":28,"text":1278,"url":28,"identifiers":28},"citation_journal_title=Proc. Natl Acad. Sci. USA; citation_title=Head-to-head antisense transcription and R-loop formation promotes transcriptional activation; citation_author=R Boque-Sastre; citation_volume=112; citation_publication_date=2015; citation_pages=5785-5790; citation_id=CR78",{"id":28,"text":1280,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=GADD45A binds R-loops and recruits TET1 to CpG island promoters; citation_author=K Arab; citation_volume=51; citation_publication_date=2019; citation_pages=217-223; citation_id=CR79",{"id":28,"text":1282,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=R-loop mediated trans action of the APOLO long noncoding RNA; citation_author=F Ariel; citation_volume=77; citation_publication_date=2020; citation_pages=1055-1065.e4; citation_id=CR80",{"id":28,"text":1284,"url":28,"identifiers":28},"citation_journal_title=Science; citation_title=Divergent transcription from active promoters; citation_author=AC Seila; citation_volume=322; citation_publication_date=2008; citation_pages=1849-1851; citation_id=CR81",{"id":28,"text":1286,"url":28,"identifiers":28},"citation_journal_title=Cell Stem Cell; citation_title=Divergent lncRNAs regulate gene expression and lineage differentiation in pluripotent cells; citation_author=S Luo; citation_volume=18; citation_publication_date=2016; citation_pages=637-652; citation_id=CR82",{"id":28,"text":1288,"url":28,"identifiers":28},"citation_journal_title=Nat. Rev. Genet.; citation_title=Regulation of gene expression by cis-acting long non-coding RNAs; citation_author=N Gil, I Ulitsky; citation_volume=21; citation_publication_date=2019; citation_pages=102-117; citation_id=CR83",{"id":28,"text":1290,"url":28,"identifiers":28},"citation_journal_title=Nat. Rev. Genet.; citation_title=Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation; citation_author=A Wutz; citation_volume=12; citation_publication_date=2011; citation_pages=542-553; citation_id=CR84",{"id":28,"text":1292,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Translating dosage compensation to trisomy 21; citation_author=J Jiang; citation_volume=500; citation_publication_date=2013; citation_pages=296-300; citation_id=CR85",{"id":28,"text":1294,"url":28,"identifiers":28},"citation_journal_title=Science; citation_title=The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome; citation_author=JM Engreitz; citation_volume=341; citation_publication_date=2013; citation_pages=1237973; citation_id=CR86",{"id":28,"text":1296,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Structural organization of the inactive X chromosome in the mouse; citation_author=L Giorgetti; citation_volume=535; citation_publication_date=2016; citation_pages=575-579; citation_id=CR87",{"id":28,"text":1298,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=A protein assembly mediates Xist localization and gene silencing; citation_author=A Pandya-Jones; citation_volume=587; citation_publication_date=2020; citation_pages=1-7; citation_id=CR88",{"id":28,"text":1300,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=A strand-specific switch in noncoding transcription switches the function of a Polycomb\u002FTrithorax response element; citation_author=VA Herzog; citation_volume=46; citation_publication_date=2014; citation_pages=973-981; citation_id=CR89",{"id":28,"text":1302,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=RNA–DNA strand exchange by the Drosophila Polycomb complex PRC2; citation_author=C Alecki; citation_volume=11; citation_publication_date=2020; citation_id=CR90",{"id":28,"text":1304,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=Mutually exclusive sense-antisense transcription at FLC facilitates environmentally induced gene repression; citation_author=S Rosa, S Duncan, C Dean; citation_volume=7; citation_publication_date=2016; citation_id=CR91",{"id":28,"text":1306,"url":28,"identifiers":28},"citation_journal_title=Proc. Natl Acad. Sci. USA; citation_title=Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization; citation_author=T Csorba, JI Questa, Q Sun, C Dean; citation_volume=111; citation_publication_date=2014; citation_pages=16160-16165; citation_id=CR92",{"id":28,"text":1308,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions; citation_author=L Stojic; citation_volume=7; citation_publication_date=2016; citation_id=CR93",{"id":28,"text":1310,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell. Biol.; citation_title=Transcription regulation by the noncoding RNA SRG1 requires Spt2-dependent chromatin deposition in the wake of RNA polymerase II; citation_author=P Thebault; citation_volume=31; citation_publication_date=2011; citation_pages=1288-1300; citation_id=CR94",{"id":28,"text":1312,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability; citation_author=A Rom; citation_volume=10; citation_publication_date=2019; citation_id=CR95",{"id":28,"text":1314,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=The non-coding Air RNA is required for silencing autosomal imprinted genes; citation_author=F Sleutels, R Zwart, DP Barlow; citation_volume=415; citation_publication_date=2002; citation_pages=810-813; citation_id=CR96",{"id":28,"text":1316,"url":28,"identifiers":28},"citation_journal_title=Cell Cycle; citation_title=Silencing by the imprinted Airn macro lncRNA: transcription is the answer; citation_author=F Santoro, FM Pauler; citation_volume=12; citation_publication_date=2013; citation_pages=711-712; citation_id=CR97",{"id":28,"text":1318,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=An atlas of active enhancers across human cell types and tissues; citation_author=R Andersson; citation_volume=507; citation_publication_date=2014; citation_pages=455-461; citation_id=CR98",{"id":28,"text":1320,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=An atlas of human long non-coding RNAs with accurate 5′ ends; citation_author=CC Hon; citation_volume=543; citation_publication_date=2017; citation_pages=199-204; citation_id=CR99",{"id":28,"text":1322,"url":28,"identifiers":28},"citation_journal_title=Genome Res.; citation_title=Global transcriptional activity dynamics reveal functional enhancer RNAs; citation_author=YJ Kim, P Xie, L Cao, MQ Zhang, TH Kim; citation_volume=28; citation_publication_date=2018; citation_pages=1799-1811; citation_id=CR100",{"id":28,"text":1324,"url":28,"identifiers":28},"citation_journal_title=Oncogene; citation_title=HPSE enhancer RNA promotes cancer progression through driving chromatin looping and regulating hnRNPU\u002Fp300\u002FEGR1\u002FHPSE axis; citation_author=W Jiao; citation_volume=37; citation_publication_date=2018; citation_pages=2728-2745; citation_id=CR101",{"id":28,"text":1326,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation; citation_author=W Li; citation_volume=498; citation_publication_date=2013; citation_pages=516-520; citation_id=CR102",{"id":28,"text":1328,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Widespread transcription at neuronal activity-regulated enhancers; citation_author=TK Kim; citation_volume=465; citation_publication_date=2010; citation_pages=182-187; citation_id=CR103",{"id":28,"text":1330,"url":28,"identifiers":28},"citation_journal_title=Genome Biol.; citation_title=Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAs; citation_author=AC Marques; citation_volume=14; citation_publication_date=2013; citation_id=CR104",{"id":28,"text":1332,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Long noncoding RNAs with enhancer-like function in human cells; citation_author=UA Orom; citation_volume=143; citation_publication_date=2010; citation_pages=46-58; citation_id=CR105",{"id":28,"text":1334,"url":28,"identifiers":28},"citation_journal_title=PLoS Biol.; citation_title=A large fraction of extragenic RNA Pol II transcription sites overlap enhancers; citation_author=F Santa; citation_volume=8; citation_publication_date=2010; citation_id=CR106",{"id":28,"text":1336,"url":28,"identifiers":28},"citation_journal_title=Cell Syst.; citation_title=Production of spliced long noncoding RNAs specifies regions with increased enhancer activity; citation_author=N Gil, I Ulitsky; citation_volume=7; citation_publication_date=2018; citation_pages=537-547.e3; citation_id=CR107",{"id":28,"text":1338,"url":28,"identifiers":28},"citation_journal_title=Life Sci. Alliance; citation_title=Splicing of enhancer-associated lincRNAs contributes to enhancer activity; citation_author=JY Tan, A Biasini, RS Young, AC Marques; citation_volume=3; citation_publication_date=2020; citation_id=CR108",{"id":28,"text":1340,"url":28,"identifiers":28},"citation_journal_title=Genome Biol.; citation_title=Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci; citation_author=PP Amaral; citation_volume=19; citation_publication_date=2018; citation_id=CR109",{"id":28,"text":1342,"url":28,"identifiers":28},"citation_journal_title=Cell Rep.; citation_title=cis-Acting complex-trait-associated lincRNA expression correlates with modulation of chromosomal architecture; citation_author=JY Tan; citation_volume=18; citation_publication_date=2017; citation_pages=2280-2288; citation_id=CR110",{"id":28,"text":1344,"url":28,"identifiers":28},"citation_journal_title=Trends Genet.; citation_title=Enhancer-derived lncRNAs regulate genome architecture: fact or fiction?; citation_author=S Fanucchi, MM Mhlanga; citation_volume=33; citation_publication_date=2017; citation_pages=375-377; citation_id=CR111",{"id":28,"text":1346,"url":28,"identifiers":28},"citation_journal_title=Nat. Rev. Mol. Cell Biol.; citation_title=The role of transcription in shaping the spatial organization of the genome; citation_author=B Steensel, EEM Furlong; citation_volume=20; citation_publication_date=2019; citation_pages=327-337; citation_id=CR112",{"id":28,"text":1348,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=A lncRNA–SWI\u002FSNF complex crosstalk controls transcriptional activation at specific promoter regions; citation_author=E Grossi; citation_volume=11; citation_publication_date=2020; citation_id=CR113",{"id":28,"text":1350,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation; citation_author=S Tomita; citation_volume=6; citation_publication_date=2015; citation_id=CR114",{"id":28,"text":1352,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=Genome-wide characterization of mammalian promoters with distal enhancer functions; citation_author=LTM Dao; citation_volume=49; citation_publication_date=2017; citation_pages=1073-1081; citation_id=CR115",{"id":28,"text":1354,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Local regulation of gene expression by lncRNA promoters, transcription and splicing; citation_author=JM Engreitz; citation_volume=539; citation_publication_date=2016; citation_pages=452-455; citation_id=CR116",{"id":28,"text":1356,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Unlinking an lncRNA from its associated cis element; citation_author=VR Paralkar; citation_volume=62; citation_publication_date=2016; citation_pages=104-110; citation_id=CR117",{"id":28,"text":1358,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development; citation_author=KM Anderson; citation_volume=539; citation_publication_date=2016; citation_pages=433-436; citation_id=CR118",{"id":28,"text":1360,"url":28,"identifiers":28},"citation_journal_title=Cell Rep.; citation_title=HAND2 target gene regulatory networks control atrioventricular canal and cardiac valve development; citation_author=F Laurent; citation_volume=19; citation_publication_date=2017; citation_pages=1602-1613; citation_id=CR119",{"id":28,"text":1362,"url":28,"identifiers":28},"citation_journal_title=Development; citation_title=The lncRNA Hand2os1\u002FUph locus orchestrates heart development through regulation of precise expression of Hand2; citation_author=X Han; citation_volume=146; citation_publication_date=2019; citation_pages=dev176198; citation_id=CR120",{"id":28,"text":1364,"url":28,"identifiers":28},"citation_journal_title=Dev. Cell; citation_title=The lncRNA locus Handsdown regulates cardiac gene programs and is essential for early mouse development; citation_author=N Ritter; citation_volume=50; citation_publication_date=2019; citation_pages=644-657.e8; citation_id=CR121",{"id":28,"text":1366,"url":28,"identifiers":28},"citation_journal_title=Cell Stem Cell; citation_title=Opposing roles for the lncRNA Haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation; citation_author=Y Yin; citation_volume=16; citation_publication_date=2015; citation_pages=504-516; citation_id=CR122",{"id":28,"text":1368,"url":28,"identifiers":28},"citation_journal_title=Nat. Rev. Mol. Cell Biol.; citation_title=Biomolecular condensates: organizers of cellular biochemistry; citation_author=SF Banani, HO Lee, AA Hyman, MK Rosen; citation_volume=18; citation_publication_date=2017; citation_pages=285-298; citation_id=CR123",{"id":28,"text":1370,"url":28,"identifiers":28},"citation_journal_title=J. Cell Biol.; citation_title=Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization; citation_author=JA West; citation_volume=214; citation_publication_date=2016; citation_pages=817-830; citation_id=CR124",{"id":28,"text":1372,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles; citation_author=CM Clemson; citation_volume=33; citation_publication_date=2009; citation_pages=717-726; citation_id=CR125",{"id":28,"text":1374,"url":28,"identifiers":28},"citation_journal_title=BMC Genomics; citation_title=A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains; citation_author=JN Hutchinson; citation_volume=8; citation_publication_date=2007; citation_id=CR126",{"id":28,"text":1376,"url":28,"identifiers":28},"citation_journal_title=Proc. Natl Acad. Sci. USA; citation_title=MENε\u002Fβ noncoding RNAs are essential for structural integrity of nuclear paraspeckles; citation_author=YT Sasaki, T Ideue, M Sano, T Mituyama, T Hirose; citation_volume=106; citation_publication_date=2009; citation_pages=2525-2530; citation_id=CR127",{"id":28,"text":1378,"url":28,"identifiers":28},"citation_journal_title=Genome Res.; citation_title=MEN ε\u002Fβ nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles; citation_author=H Sunwoo; citation_volume=19; citation_publication_date=2009; citation_pages=347-359; citation_id=CR128",{"id":28,"text":1380,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation; citation_author=T Yamazaki; citation_volume=70; citation_publication_date=2018; citation_pages=1038-1053 e1037; citation_id=CR129",{"id":28,"text":1382,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Res.; citation_title=Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions that may contribute to paraspeckle architecture; citation_author=Y Lin, BF Schmidt, MP Bruchez, CJ McManus; citation_volume=46; citation_publication_date=2018; citation_pages=3742-3752; citation_id=CR130",{"id":28,"text":1384,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=RNA duplex map in living cells reveals higher-order transcriptome structure; citation_author=Z Lu; citation_volume=165; citation_publication_date=2016; citation_pages=1267-1279; citation_id=CR131",{"id":28,"text":1386,"url":28,"identifiers":28},"citation_journal_title=Genes Dev.; citation_title=A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tails; citation_author=JE Wilusz; citation_volume=26; citation_publication_date=2012; citation_pages=2392-2407; citation_id=CR132",{"id":28,"text":1388,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=RNA–RNA interactions enable specific targeting of noncoding RNAs to nascent pre-mRNAs and chromatin sites; citation_author=JM Engreitz; citation_volume=159; citation_publication_date=2014; citation_pages=188-199; citation_id=CR133",{"id":28,"text":1390,"url":28,"identifiers":28},"citation_journal_title=Mol. Biol. Cell; citation_title=SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles; citation_author=V Tripathi; citation_volume=23; citation_publication_date=2012; citation_pages=3694-3706; citation_id=CR134",{"id":28,"text":1392,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs; citation_author=L Yang; citation_volume=147; citation_publication_date=2011; citation_pages=773-788; citation_id=CR135",{"id":28,"text":1394,"url":28,"identifiers":28},"citation_journal_title=Genes Dev.; citation_title=Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss; citation_author=G Arun; citation_volume=30; citation_publication_date=2016; citation_pages=34-51; citation_id=CR136",{"id":28,"text":1396,"url":28,"identifiers":28},"citation_journal_title=Cancer Res.; citation_title=Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation; citation_author=P Malakar; citation_volume=77; citation_publication_date=2017; citation_pages=1155-1167; citation_id=CR137",{"id":28,"text":1398,"url":28,"identifiers":28},"citation_journal_title=J. Cell Sci.; citation_title=Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution; citation_author=J Fei; citation_volume=130; citation_publication_date=2017; citation_pages=4180-4192; citation_id=CR138",{"id":28,"text":1400,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=RIC-seq for global in situ profiling of RNA–RNA spatial interactions; citation_author=Z Cai; citation_volume=582; citation_publication_date=2020; citation_pages=432-437; citation_id=CR139",{"id":28,"text":1402,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Long noncoding RNAs with snoRNA ends; citation_author=QF Yin; citation_volume=48; citation_publication_date=2012; citation_pages=219-230; citation_id=CR140",{"id":28,"text":1404,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Unusual processing generates SPA lncRNAs that sequester multiple RNA binding proteins; citation_author=H Wu; citation_volume=64; citation_publication_date=2016; citation_pages=534-548; citation_id=CR141",{"id":28,"text":1406,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=A short tandem repeat-enriched RNA assembles a nuclear compartment to control alternative splicing and promote cell survival; citation_author=K Yap; citation_volume=72; citation_publication_date=2018; citation_pages=525-540.e13; citation_id=CR142",{"id":28,"text":1408,"url":28,"identifiers":28},"citation_journal_title=Proc. Natl Acad. Sci. USA; citation_title=Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules; citation_author=C Jolly, Y Usson, RI Morimoto; citation_volume=96; citation_publication_date=1999; citation_pages=6769-6774; citation_id=CR143",{"id":28,"text":1410,"url":28,"identifiers":28},"citation_journal_title=J. Cell Sci.; citation_title=A novel hnRNP protein (HAP\u002FSAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock; citation_author=F Weighardt; citation_volume=112; citation_publication_date=1999; citation_pages=1465-1476; citation_id=CR144",{"id":28,"text":1412,"url":28,"identifiers":28},"citation_journal_title=Mol. Biol. Cell; citation_title=Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors; citation_author=M Denegri; citation_volume=12; citation_publication_date=2001; citation_pages=3502-3514; citation_id=CR145",{"id":28,"text":1414,"url":28,"identifiers":28},"citation_journal_title=J. Cell Sci.; citation_title=A key role for stress-induced satellite III transcripts in the relocalization of splicing factors into nuclear stress granules; citation_author=A Metz, J Soret, C Vourc’h, J Tazi, C Jolly; citation_volume=117; citation_publication_date=2004; citation_pages=4551-4558; citation_id=CR146",{"id":28,"text":1416,"url":28,"identifiers":28},"citation_journal_title=J. Cell Biol.; citation_title=Stress-induced transcription of satellite III repeats; citation_author=C Jolly; citation_volume=164; citation_publication_date=2004; citation_pages=25-33; citation_id=CR147",{"id":28,"text":1418,"url":28,"identifiers":28},"citation_journal_title=EMBO J.; citation_title=lncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation; citation_author=K Ninomiya; citation_volume=39; citation_publication_date=2020; citation_id=CR148",{"id":28,"text":1420,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Immobilization of proteins in the nucleolus by ribosomal intergenic spacer noncoding RNA; citation_author=TE Audas, MD Jacob, S Lee; citation_volume=45; citation_publication_date=2012; citation_pages=147-157; citation_id=CR149",{"id":28,"text":1422,"url":28,"identifiers":28},"citation_journal_title=Cell Rep.; citation_title=Stress-induced low complexity RNA activates physiological amyloidogenesis; citation_author=M Wang; citation_volume=24; citation_publication_date=2018; citation_pages=1713-1721.e4; citation_id=CR150",{"id":28,"text":1424,"url":28,"identifiers":28},"citation_journal_title=Nat. Struct. Mol. Biol.; citation_title=Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre; citation_author=E Hacisuleyman; citation_volume=21; citation_publication_date=2014; citation_pages=198-206; citation_id=CR151",{"id":28,"text":1426,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis; citation_author=JP Lewandowski; citation_volume=10; citation_publication_date=2019; citation_id=CR152",{"id":28,"text":1428,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Inter-chromosomal contact properties in live-cell imaging and in Hi-C; citation_author=PG Maass, AR Barutcu, CL Weiner, JL Rinn; citation_volume=69; citation_publication_date=2018; citation_pages=1039-1045.e3; citation_id=CR153",{"id":28,"text":1430,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell. Biol.; citation_title=When long noncoding becomes protein coding; citation_author=CCR Hartford, A Lal; citation_volume=40; citation_publication_date=2020; citation_id=CR154",{"id":28,"text":1432,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Res.; citation_title=Splicing regulation by long noncoding RNAs; citation_author=N Romero-Barrios, MF Legascue, M Benhamed, F Ariel, M Crespi; citation_volume=46; citation_publication_date=2018; citation_pages=2169-2184; citation_id=CR155",{"id":28,"text":1434,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins; citation_author=S Lee; citation_volume=164; citation_publication_date=2016; citation_pages=69-80; citation_id=CR156",{"id":28,"text":1436,"url":28,"identifiers":28},"citation_journal_title=Genes Dev.; citation_title=SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA; citation_author=A Tichon, RB Perry, L Stojic, I Ulitsky; citation_volume=32; citation_publication_date=2018; citation_pages=70-78; citation_id=CR157",{"id":28,"text":1438,"url":28,"identifiers":28},"citation_journal_title=Wiley Interdiscip. Rev. RNA; citation_title=Roles of Puf proteins in mRNA degradation and translation; citation_author=MA Miller, WM Olivas; citation_volume=2; citation_publication_date=2011; citation_pages=471-492; citation_id=CR158",{"id":28,"text":1440,"url":28,"identifiers":28},"citation_journal_title=Cancer Cell; citation_title=A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis; citation_author=B Liu; citation_volume=27; citation_publication_date=2015; citation_pages=370-381; citation_id=CR159",{"id":28,"text":1442,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Control of somatic tissue differentiation by the long non-coding RNA TINCR; citation_author=M Kretz; citation_volume=493; citation_publication_date=2013; citation_pages=231-235; citation_id=CR160",{"id":28,"text":1444,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements; citation_author=C Gong, LE Maquat; citation_volume=470; citation_publication_date=2011; citation_pages=284-288; citation_id=CR161",{"id":28,"text":1446,"url":28,"identifiers":28},"citation_journal_title=Genes Dev.; citation_title=Control of myogenesis by rodent SINE-containing lncRNAs; citation_author=J Wang, C Gong, LE Maquat; citation_volume=27; citation_publication_date=2013; citation_pages=793-804; citation_id=CR162",{"id":28,"text":1448,"url":28,"identifiers":28},"citation_journal_title=Exp. Dermatol.; citation_title=TINCR is not a non-coding RNA but encodes a protein component of cornified epidermal keratinocytes; citation_author=L Eckhart, J Lachner, E Tschachler, RH Rice; citation_volume=29; citation_publication_date=2020; citation_pages=376-379; citation_id=CR163",{"id":28,"text":1450,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat; citation_author=C Carrieri; citation_volume=491; citation_publication_date=2012; citation_pages=454-457; citation_id=CR164",{"id":28,"text":1452,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA; citation_author=M Cesana; citation_volume=147; citation_publication_date=2011; citation_pages=358-369; citation_id=CR165",{"id":28,"text":1454,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?; citation_author=L Salmena, L Poliseno, Y Tay, L Kats, PP Pandolfi; citation_volume=146; citation_publication_date=2011; citation_pages=353-358; citation_id=CR166",{"id":28,"text":1456,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition; citation_author=AD Bosson, JR Zamudio, PA Sharp; citation_volume=56; citation_publication_date=2014; citation_pages=347-359; citation_id=CR167",{"id":28,"text":1458,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance; citation_author=R Denzler, V Agarwal, J Stefano, DP Bartel, M Stoffel; citation_volume=54; citation_publication_date=2014; citation_pages=766-776; citation_id=CR168",{"id":28,"text":1460,"url":28,"identifiers":28},"citation_journal_title=Nat. Cell Biol.; citation_title=A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression; citation_author=S Grelet; citation_volume=19; citation_publication_date=2017; citation_pages=1105-1115; citation_id=CR169",{"id":28,"text":1462,"url":28,"identifiers":28},"citation_journal_title=Noncoding RNA; citation_title=Vesiculated long non-coding RNAs: offshore packages deciphering trans-regulation between cells, cancer progression and resistance to therapies; citation_author=F Fatima, M Nawaz; citation_volume=3; citation_publication_date=2017; citation_pages=10; citation_id=CR170",{"id":28,"text":1464,"url":28,"identifiers":28},"citation_journal_title=Crit. Rev. Oncol. Hematol.; citation_title=The effects of mitochondria-associated long noncoding RNAs in cancer mitochondria: new players in an old arena; citation_author=Y Zhao, L Sun, RR Wang, JF Hu, J Cui; citation_volume=131; citation_publication_date=2018; citation_pages=76-82; citation_id=CR171",{"id":28,"text":1466,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=Melanoma addiction to the long non-coding RNA SAMMSON; citation_author=E Leucci; citation_volume=531; citation_publication_date=2016; citation_pages=518-522; citation_id=CR172",{"id":28,"text":1468,"url":28,"identifiers":28},"citation_journal_title=Nat. Struct. Mol. Biol.; citation_title=SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation; citation_author=R Vendramin; citation_volume=25; citation_publication_date=2018; citation_pages=1035-1046; citation_id=CR173",{"id":28,"text":1470,"url":28,"identifiers":28},"citation_journal_title=Nat. Rev.Genet.; citation_title=Long non-coding RNAs: new players in cell differentiation and development; citation_author=A Fatica, I Bozzoni; citation_volume=15; citation_publication_date=2014; citation_pages=7-21; citation_id=CR174",{"id":28,"text":1472,"url":28,"identifiers":28},"citation_journal_title=Front. Cell Dev. Biol.; citation_title=Importance of long non-coding RNAs in the development and disease of skeletal muscle and cardiovascular lineages; citation_author=S Sweta, T Dudnakova, S Sudheer, AH Baker, R Bhushan; citation_volume=7; citation_publication_date=2019; citation_pages=228; citation_id=CR175",{"id":28,"text":1474,"url":28,"identifiers":28},"citation_journal_title=Front. Physiol.; citation_title=Long non-coding RNAs: at the heart of cardiac dysfunction?; citation_author=L Hobuss, C Bar, T Thum; citation_volume=10; citation_publication_date=2019; citation_pages=30; citation_id=CR176",{"id":28,"text":1476,"url":28,"identifiers":28},"citation_journal_title=Diabetes; citation_title=Function and mechanism of long noncoding RNAs in adipocyte biology; citation_author=L Sun, JD Lin; citation_volume=68; citation_publication_date=2019; citation_pages=887-896; citation_id=CR177",{"id":28,"text":1478,"url":28,"identifiers":28},"citation_journal_title=Nat. Immunol.; citation_title=Gene regulation in the immune system by long noncoding RNAs; citation_author=YG Chen, AT Satpathy, HY Chang; citation_volume=18; citation_publication_date=2017; citation_pages=962-972; citation_id=CR178",{"id":28,"text":1480,"url":28,"identifiers":28},"citation_journal_title=Cold Spring Harb. Symp. Quant. Biol.; citation_title=Long noncoding RNAs in development and regeneration of the neural lineage; citation_author=H Hezroni, RBT Perry, I Ulitsky; citation_volume=84; citation_publication_date=2019; citation_pages=165-177; citation_id=CR179",{"id":28,"text":1482,"url":28,"identifiers":28},"citation_journal_title=Neuron; citation_title=Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution; citation_author=JA Briggs, EJ Wolvetang, JS Mattick, JL Rinn, G Barry; citation_volume=88; citation_publication_date=2015; citation_pages=861-877; citation_id=CR180",{"id":28,"text":1484,"url":28,"identifiers":28},"citation_journal_title=eLife; citation_title=Multiple knockout mouse models reveal lincRNAs are required for life and brain development; citation_author=M Sauvageau; citation_volume=2; citation_publication_date=2013; citation_id=CR181",{"id":28,"text":1486,"url":28,"identifiers":28},"citation_journal_title=Neuron; citation_title=lncRNA functional networks in oligodendrocytes reveal stage-specific myelination control by an lncOL1\u002FSuz12 complex in the CNS; citation_author=D He; citation_volume=93; citation_publication_date=2017; citation_pages=362-378; citation_id=CR182",{"id":28,"text":1488,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Regulation of neuroregeneration by long noncoding RNAs; citation_author=RB Perry, H Hezroni, MJ Goldrich, I Ulitsky; citation_volume=72; citation_publication_date=2018; citation_pages=553-567.e5; citation_id=CR183",{"id":28,"text":1490,"url":28,"identifiers":28},"citation_journal_title=Front. Behav. Neurosci.; citation_title=The role of long noncoding RNAs in central nervous system and neurodegenerative diseases; citation_author=CW Wei, T Luo, SS Zou, AS Wu; citation_volume=12; citation_publication_date=2018; citation_pages=175; citation_id=CR184",{"id":28,"text":1492,"url":28,"identifiers":28},"citation_journal_title=Genome Biol.; citation_title=Evidence for natural antisense transcript-mediated inhibition of microRNA function; citation_author=MA Faghihi; citation_volume=11; citation_publication_date=2010; citation_id=CR185",{"id":28,"text":1494,"url":28,"identifiers":28},"citation_journal_title=BMC Neurol.; citation_title=Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease; citation_author=L Feng; citation_volume=18; citation_publication_date=2018; citation_id=CR186",{"id":28,"text":1496,"url":28,"identifiers":28},"citation_journal_title=Cell Stem Cell; citation_title=Long non-coding RNAs control hematopoietic stem cell function; citation_author=M Luo; citation_volume=16; citation_publication_date=2015; citation_pages=426-438; citation_id=CR187",{"id":28,"text":1498,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation; citation_author=MK Atianand; citation_volume=165; citation_publication_date=2016; citation_pages=1672-1685; citation_id=CR188",{"id":28,"text":1500,"url":28,"identifiers":28},"citation_journal_title=Science; citation_title=A long noncoding RNA associated with susceptibility to celiac disease; citation_author=A Castellanos-Rubio; citation_volume=352; citation_publication_date=2016; citation_pages=91-95; citation_id=CR189",{"id":28,"text":1502,"url":28,"identifiers":28},"citation_journal_title=mBio; citation_title=Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling; citation_author=X Peng; citation_volume=1; citation_publication_date=2010; citation_pages=e00206-e00210; citation_id=CR190",{"id":28,"text":1504,"url":28,"identifiers":28},"citation_journal_title=Noncoding RNA; citation_title=Long non-coding RNAs and the innate immune response; citation_author=MR Hadjicharalambous, MA Lindsay; citation_volume=5; citation_publication_date=2019; citation_pages=34; citation_id=CR191",{"id":28,"text":1506,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Res.; citation_title=Negative regulation of the interferon response by an interferon-induced long non-coding RNA; citation_author=H Kambara; citation_volume=42; citation_publication_date=2014; citation_pages=10668-10680; citation_id=CR192",{"id":28,"text":1508,"url":28,"identifiers":28},"citation_journal_title=EMBO Rep.; citation_title=Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication; citation_author=E Carnero; citation_volume=17; citation_publication_date=2016; citation_pages=1013-1028; citation_id=CR193",{"id":28,"text":1510,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Res.; citation_title=Lnc2Cancer v2.0: updated database of experimentally supported long non-coding RNAs in human cancers; citation_author=Y Gao; citation_volume=47; citation_publication_date=2019; citation_pages=D1028-D1033; citation_id=CR194",{"id":28,"text":1512,"url":28,"identifiers":28},"citation_journal_title=Commun. Biol.; citation_title=Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis; citation_author=J Carlevaro-Fita; citation_volume=3; citation_publication_date=2020; citation_pages=56; citation_id=CR195",{"id":28,"text":1514,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature; citation_author=Y Sanchez; citation_volume=5; citation_publication_date=2014; citation_id=CR196",{"id":28,"text":1516,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response; citation_author=M Huarte; citation_volume=142; citation_publication_date=2010; citation_pages=409-419; citation_id=CR197",{"id":28,"text":1518,"url":28,"identifiers":28},"citation_journal_title=Oncotarget; citation_title=MYC regulates the non-coding transcriptome; citation_author=JR Hart, TC Roberts, MS Weinberg, KV Morris, PK Vogt; citation_volume=5; citation_publication_date=2014; citation_pages=12543-12554; citation_id=CR198",{"id":28,"text":1520,"url":28,"identifiers":28},"Kim, T. et al. Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. J. Natl Cancer Inst. 107, \n                  https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjnci\u002Fdju505\n                  \n                 (2015).",{"id":28,"text":1522,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=The oestrogen receptor α-regulated lncRNA NEAT1 is a critical modulator of prostate cancer; citation_author=D Chakravarty; citation_volume=5; citation_publication_date=2014; citation_id=CR200",{"id":28,"text":1524,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Genome-wide mapping and characterization of notch-regulated long noncoding RNAs in acute leukemia; citation_author=T Trimarchi; citation_volume=158; citation_publication_date=2014; citation_pages=593-606; citation_id=CR201",{"id":28,"text":1526,"url":28,"identifiers":28},"citation_journal_title=Cell Rep.; citation_title=In vivo characterization of Linc-p21 reveals functional cis-regulatory DNA elements; citation_author=AF Groff; citation_volume=16; citation_publication_date=2016; citation_pages=2178-2186; citation_id=CR202",{"id":28,"text":1528,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=lincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1\u002FS checkpoint; citation_author=N Dimitrova; citation_volume=54; citation_publication_date=2014; citation_pages=777-790; citation_id=CR203",{"id":28,"text":1530,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters; citation_author=T Hung; citation_volume=43; citation_publication_date=2011; citation_pages=621-629; citation_id=CR204",{"id":28,"text":1532,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=An inducible long noncoding RNA amplifies DNA damage signaling; citation_author=AM Schmitt; citation_volume=48; citation_publication_date=2016; citation_pages=1370-1376; citation_id=CR205",{"id":28,"text":1534,"url":28,"identifiers":28},"citation_journal_title=Nat. Cell Biol.; citation_title=GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability; citation_author=WL Hu; citation_volume=20; citation_publication_date=2018; citation_pages=492-502; citation_id=CR206",{"id":28,"text":1536,"url":28,"identifiers":28},"citation_journal_title=J. Mol. Endocrinol.; citation_title=MEG3 noncoding RNA: a tumor suppressor; citation_author=Y Zhou, X Zhang, A Klibanski; citation_volume=48; citation_publication_date=2012; citation_pages=R45-R53; citation_id=CR207",{"id":28,"text":1538,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway; citation_author=T Uroda; citation_volume=75; citation_publication_date=2019; citation_pages=982-995.e9; citation_id=CR208",{"id":28,"text":1540,"url":28,"identifiers":28},"citation_journal_title=FASEB J.; citation_title=Long noncoding RNAs as a novel component of the Myc transcriptional network; citation_author=M Winkle; citation_volume=29; citation_publication_date=2015; citation_pages=2338-2346; citation_id=CR209",{"id":28,"text":1542,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=PVT1 dependence in cancer with MYC copy-number increase; citation_author=YY Tseng; citation_volume=512; citation_publication_date=2014; citation_pages=82-86; citation_id=CR210",{"id":28,"text":1544,"url":28,"identifiers":28},"citation_journal_title=Cancer Cell; citation_title=lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer; citation_author=Z Wang; citation_volume=33; citation_publication_date=2018; citation_pages=706-720.e9; citation_id=CR211",{"id":28,"text":1546,"url":28,"identifiers":28},"citation_journal_title=PLoS Genet.; citation_title=Functional enhancers at the gene-poor 8q24 cancer-linked locus; citation_author=L Jia; citation_volume=5; citation_publication_date=2009; citation_id=CR212",{"id":28,"text":1548,"url":28,"identifiers":28},"citation_journal_title=Cancer Res.; citation_title=Lessons from functional analysis of genome-wide association studies; citation_author=I Sur, S Tuupanen, T Whitington, LA Aaltonen, J Taipale; citation_volume=73; citation_publication_date=2013; citation_pages=4180-4184; citation_id=CR213",{"id":28,"text":1550,"url":28,"identifiers":28},"citation_journal_title=Genome Res.; citation_title=CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer; citation_author=H Ling; citation_volume=23; citation_publication_date=2013; citation_pages=1446-1461; citation_id=CR214",{"id":28,"text":1552,"url":28,"identifiers":28},"citation_journal_title=Proc. Natl Acad. Sci. USA; citation_title=Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5; citation_author=T Kim; citation_volume=111; citation_publication_date=2014; citation_pages=4173-4178; citation_id=CR215",{"id":28,"text":1554,"url":28,"identifiers":28},"citation_journal_title=Nat. Biotechnol.; citation_title=Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression; citation_author=JR Prensner; citation_volume=29; citation_publication_date=2011; citation_pages=742-749; citation_id=CR216",{"id":28,"text":1556,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs; citation_author=L Yang; citation_volume=500; citation_publication_date=2013; citation_pages=598-602; citation_id=CR217",{"id":28,"text":1558,"url":28,"identifiers":28},"citation_journal_title=Biochem. Biophys. Res. Commun.; citation_title=Long non-coding RNA PVT1 and cancer; citation_author=M Cui; citation_volume=471; citation_publication_date=2016; citation_pages=10-14; citation_id=CR218",{"id":28,"text":1560,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element; citation_author=SW Cho; citation_volume=173; citation_publication_date=2018; citation_pages=1398-1412.e22; citation_id=CR219",{"id":28,"text":1562,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Antisense-mediated transcript knockdown triggers premature transcription termination; citation_author=JS Lee, JT Mendell; citation_volume=77; citation_publication_date=2020; citation_pages=1044-1054.e3; citation_id=CR220",{"id":28,"text":1564,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Directed RNase H cleavage of nascent transcripts causes transcription termination; citation_author=F Lai, SS Damle, KK Ling, F Rigo; citation_volume=77; citation_publication_date=2020; citation_pages=1032-1043.e4; citation_id=CR221",{"id":28,"text":1566,"url":28,"identifiers":28},"citation_journal_title=J. Biol. Chem.; citation_title=Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression; citation_author=BP Monia; citation_volume=268; citation_publication_date=1993; citation_pages=14514-14522; citation_id=CR222",{"id":28,"text":1568,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Symp. Ser.; citation_title=Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs; citation_author=PP Seth; citation_volume=52; citation_publication_date=2008; citation_pages=553-554; citation_id=CR223",{"id":28,"text":1570,"url":28,"identifiers":28},"citation_journal_title=Ther. Deliv.; citation_title=Current progress on aptamer-targeted oligonucleotide therapeutics; citation_author=JP Dassie, PH Giangrande; citation_volume=4; citation_publication_date=2013; citation_pages=1527-1546; citation_id=CR224",{"id":28,"text":1572,"url":28,"identifiers":28},"citation_journal_title=J. Clin. Med.; citation_title=Antisense oligonucleotides: an emerging area in drug discovery and development; citation_author=K Dhuri; citation_volume=9; citation_publication_date=2020; citation_pages=2004; citation_id=CR225",{"id":28,"text":1574,"url":28,"identifiers":28},"citation_journal_title=Nat. Rev. Drug Discov.; citation_title=Principles for targeting RNA with drug-like small molecules; citation_author=KD Warner, CE Hajdin, KM Weeks; citation_volume=17; citation_publication_date=2018; citation_pages=547-558; citation_id=CR226",{"id":28,"text":1576,"url":28,"identifiers":28},"citation_journal_title=Cell Rep.; citation_title=COOLAIR antisense RNAs form evolutionarily conserved elaborate secondary structures; citation_author=EJ Hawkes; citation_volume=16; citation_publication_date=2016; citation_pages=3087-3096; citation_id=CR227",{"id":28,"text":1578,"url":28,"identifiers":28},"citation_journal_title=Nucleic Acids Res.; citation_title=Structural architecture of the human long non-coding RNA, steroid receptor RNA activator; citation_author=IV Novikova, SP Hennelly, KY Sanbonmatsu; citation_volume=40; citation_publication_date=2012; citation_pages=5034-5051; citation_id=CR228",{"id":28,"text":1580,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=HOTAIR forms an intricate and modular secondary structure; citation_author=S Somarowthu; citation_volume=58; citation_publication_date=2015; citation_pages=353-361; citation_id=CR229",{"id":28,"text":1582,"url":28,"identifiers":28},"citation_journal_title=Nat. Methods; citation_title=Synergistic and tunable human gene activation by combinations of synthetic transcription factors; citation_author=P Perez-Pinera; citation_volume=10; citation_publication_date=2013; citation_pages=239-242; citation_id=CR230",{"id":28,"text":1584,"url":28,"identifiers":28},"citation_journal_title=Nat. Commun.; citation_title=Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution; citation_author=DN Kim; citation_volume=11; citation_publication_date=2020; citation_id=CR231",{"id":28,"text":1586,"url":28,"identifiers":28},"citation_journal_title=Nat. Protoc.; citation_title=Genome engineering using the CRISPR–Cas9 system; citation_author=FA Ran; citation_volume=8; citation_publication_date=2013; citation_pages=2281-2308; citation_id=CR232",{"id":28,"text":1588,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression; citation_author=LS Qi; citation_volume=152; citation_publication_date=2013; citation_pages=1173-1183; citation_id=CR233",{"id":28,"text":1590,"url":28,"identifiers":28},"citation_journal_title=Nat. Methods; citation_title=RNA-guided gene activation by CRISPR–Cas9-based transcription factors; citation_author=P Perez-Pinera; citation_volume=10; citation_publication_date=2013; citation_pages=973-976; citation_id=CR234",{"id":28,"text":1592,"url":28,"identifiers":28},"citation_journal_title=Nature; citation_title=RNA targeting with CRISPR–Cas13; citation_author=OO Abudayyeh; citation_volume=550; citation_publication_date=2017; citation_pages=280-284; citation_id=CR235",{"id":28,"text":1594,"url":28,"identifiers":28},"citation_journal_title=Cancer Cell; citation_title=Hacking the cancer genome: profiling therapeutically actionable long non-coding RNAs using CRISPR–Cas9 screening; citation_author=R Esposito; citation_volume=35; citation_publication_date=2019; citation_pages=545-557; citation_id=CR236",{"id":28,"text":1596,"url":28,"identifiers":28},"citation_journal_title=Nat. Genet.; citation_title=Functional classification of long non-coding RNAs by k-mer content; citation_author=JM Kirk; citation_volume=50; citation_publication_date=2018; citation_pages=1474-1482; citation_id=CR237",{"id":28,"text":1598,"url":28,"identifiers":28},"citation_journal_title=Mol. Cell; citation_title=Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A; citation_author=K Arab; citation_volume=55; citation_publication_date=2014; citation_pages=604-614; citation_id=CR238",{"id":28,"text":1600,"url":28,"identifiers":28},"citation_journal_title=Front. Endocrinol.; citation_title=ANRIL: a lncRNA at the CDKN2A\u002FB locus with roles in cancer and metabolic disease; citation_author=Y Kong, CH Hsieh, LC Alonso; citation_volume=9; citation_publication_date=2018; citation_pages=405; citation_id=CR239",{"id":28,"text":1602,"url":28,"identifiers":28},"citation_journal_title=Curr. Biol.; citation_title=New Xist-interacting proteins in X-chromosome inactivation; citation_author=H Mira-Bontenbal, J Gribnau; citation_volume=26; citation_publication_date=2016; citation_pages=R338-R342; citation_id=CR240",{"id":28,"text":1604,"url":28,"identifiers":28},"citation_journal_title=RNA; citation_title=The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization; citation_author=MM Duszczyk, A Wutz, V Rybin, M Sattler; citation_volume=17; citation_publication_date=2011; citation_pages=1973-1982; citation_id=CR241",{"id":28,"text":1606,"url":28,"identifiers":28},"citation_journal_title=Philos. Trans. R. Soc. Lond. B Biol. Sci.; citation_title=Mechanistic insights in X-chromosome inactivation; citation_author=Z Lu, AC Carter, HY Chang; citation_volume=372; citation_publication_date=2017; citation_pages=20160356; citation_id=CR242",{"id":28,"text":1608,"url":28,"identifiers":28},"citation_journal_title=FEBS Lett.; citation_title=X-chromosome inactivation in development and cancer; citation_author=R Chaligne, E Heard; citation_volume=588; citation_publication_date=2014; citation_pages=2514-2522; citation_id=CR243",{"id":28,"text":1610,"url":28,"identifiers":28},"citation_journal_title=Cell; citation_title=Xist RNA is a potent suppressor of hematologic cancer in mice; citation_author=E Yildirim; citation_volume=152; citation_publication_date=2013; citation_pages=727-742; citation_id=CR244",{"id":28,"text":1612,"url":28,"identifiers":28},"citation_journal_title=Cell Death Dis.; citation_title=Long noncoding RNA XIST expedites metastasis and modulates epithelial–mesenchymal transition in colorectal cancer; citation_author=DL Chen; citation_volume=8; citation_publication_date=2017; citation_id=CR245",{"id":28,"text":1614,"url":28,"identifiers":28},"citation_journal_title=Epigenetics Chromatin; citation_title=Tissue-specific regulation of Igf2r\u002FAirn imprinting during gastrulation; citation_author=C Marcho, A Bevilacqua, KD Tremblay, J Mager; citation_volume=8; citation_publication_date=2015; citation_pages=10; citation_id=CR246",{"id":28,"text":1616,"url":28,"identifiers":28},"citation_journal_title=Development; citation_title=Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1; citation_author=F Mohammad, T Mondal, N Guseva, GK Pandey, C Kanduri; citation_volume=137; citation_publication_date=2010; citation_pages=2493-2499; citation_id=CR247",{"id":28,"text":1618,"url":28,"identifiers":28},"citation_journal_title=Cytogenet. Genome Res.; citation_title=Imprinting disruption of the CDKN1C\u002FKCNQ1OT1 domain: the molecular mechanisms causing Beckwith–Wiedemann syndrome and cancer; citation_author=K Higashimoto, H Soejima, T Saito, K Okumura, T Mukai; citation_volume=113; citation_publication_date=2006; citation_pages=306-312; citation_id=CR248",{"id":28,"text":1620,"url":28,"identifiers":28},"citation_journal_title=Biomed. Pharmacother.; citation_title=The functions and oncogenic roles of CCAT1 in human cancer; citation_author=Z Liu, Q Chen, SS Hann; citation_volume=115; citation_publication_date=2019; citation_pages=108943; citation_id=CR249",{"id":28,"text":1622,"url":28,"identifiers":28},"citation_journal_title=Life Sci.; citation_title=Long non-coding RNA TINCR as potential biomarker and therapeutic target for cancer; citation_author=U Sharma; citation_volume=257; citation_publication_date=2020; citation_pages=118035; citation_id=CR250",{"id":28,"text":1624,"url":28,"identifiers":28},"citation_journal_title=Nat. Immunol.; citation_title=NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death; citation_author=D Huang; citation_volume=19; citation_publication_date=2018; citation_pages=1112-1125; citation_id=CR251",{"id":28,"text":1626,"url":28,"identifiers":28},"citation_journal_title=PLoS ONE; citation_title=lncRNA-RMRP acts as an oncogene in lung cancer; citation_author=Q Meng, M Ren, Y Li, X Song; citation_volume=11; citation_publication_date=2016; citation_id=CR252",{"id":28,"text":1628,"url":28,"identifiers":28},"citation_journal_title=PLoS ONE; citation_title=RMRP is a non-coding RNA essential for early murine development; citation_author=J Rosenbluh; citation_volume=6; citation_publication_date=2011; citation_id=CR253",{"id":28,"text":1630,"url":28,"identifiers":28},"citation_journal_title=Front. Genet.; citation_title=Long non-coding RNA NEAT1: a novel target for diagnosis and therapy in human tumors; citation_author=P Dong; citation_volume=9; citation_publication_date=2018; citation_pages=471; citation_id=CR254",{"id":28,"text":1632,"url":28,"identifiers":28},"citation_journal_title=Nat. 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E. D. An overview of epithelio-mesenchymal transformation. Acta Anat. 154, 8–20 (1995).",{"doi":1867},"10.1159\u002F000147748",{"id":28,"text":1869,"url":28,"identifiers":1870},"Thiery, J. P. & Sleeman, J. P. Complex networks orchestrate epithelial-mesenchymal transitions. Nature Rev. Mol. Cell Biol. 7, 131–142 (2006).",{"doi":1871},"10.1038\u002Fnrm1835",{"id":28,"text":1873,"url":28,"identifiers":1874},"Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871–890 (2009).",{"doi":1875},"10.1016\u002Fj.cell.2009.11.007",{"id":28,"text":1877,"url":28,"identifiers":1878},"Kalluri, R. & Weinberg, R. A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 1420–1428 (2009).",{"doi":1879},"10.1172\u002FJCI39104",{"id":28,"text":1881,"url":28,"identifiers":1882},"Chapman, H. A. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu. Rev. Physiol. 73, 413–435 (2011).",{"doi":1883},"10.1146\u002Fannurev-physiol-012110-142225",{"id":28,"text":1885,"url":28,"identifiers":1886},"Huang, R. Y., Guilford, P. & Thiery, J. P. Early events in cell adhesion and polarity during epithelial-mesenchymal transition. J. Cell Sci. 125, 4417–4422 (2012).",{"doi":1887},"10.1242\u002Fjcs.099697",{"id":28,"text":1889,"url":28,"identifiers":1890},"Yilmaz, M. & Christofori, G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28, 15–33 (2009).",{"doi":1891},"10.1007\u002Fs10555-008-9169-0",{"id":28,"text":1893,"url":28,"identifiers":1894},"Niehrs, C. The complex world of WNT receptor signalling. Nature Rev. Mol. Cell Biol. 13, 767–779 (2012).",{"doi":1895},"10.1038\u002Fnrm3470",{"id":28,"text":1897,"url":28,"identifiers":1898},"Kourtidis, A., Ngok, S. P. & Anastasiadis, P. Z. p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression. Prog. Mol. Biol. Transl. Sci. 116, 409–432 (2013).",{"doi":1899},"10.1016\u002FB978-0-12-394311-8.00018-2",{"id":28,"text":1901,"url":28,"identifiers":1902},"Bax, N. A. et al. Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. J. Cell. Mol. Med. 15, 2675–2683 (2011).",{"doi":1903},"10.1111\u002Fj.1582-4934.2011.01266.x",{"id":28,"text":1905,"url":28,"identifiers":1906},"Peinado, H., Olmeda, D. & Cano, A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nature Rev. Cancer 7, 415–428 (2007).",{"doi":1907},"10.1038\u002Fnrc2131",{"id":28,"text":1909,"url":28,"identifiers":1910},"De Craene, B. & Berx, G. Regulatory networks defining EMT during cancer initiation and progression. Nature Rev. Cancer 13, 97–110 (2013).",{"doi":1911},"10.1038\u002Fnrc3447",{"id":28,"text":1913,"url":28,"identifiers":1914},"St Johnston, D. & Ahringer, J. Cell polarity in eggs and epithelia: parallels and diversity. Cell 141, 757–774 (2010).",{"doi":1915},"10.1016\u002Fj.cell.2010.05.011",{"id":28,"text":1917,"url":28,"identifiers":1918},"Navarro, C. et al. Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene 24, 4330–4339 (2005).",{"doi":1919},"10.1038\u002Fsj.onc.1208632",{"id":28,"text":1921,"url":28,"identifiers":1922},"Qin, Y., Capaldo, C., Gumbiner, B. M. & Macara, I. G. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J. Cell Biol. 171, 1061–1071 (2005). Silencing the expression of the polarity complex protein SCRIB results in loss of cell–cell adhesion, EMT and migration, similarly to silencing E-cadherin expression. These results illustrate the intimate functional linkage of epithelial cell adhesion and apical–basal polarity, and their roles in EMT.",{"doi":1923},"10.1083\u002Fjcb.200506094",{"id":28,"text":1925,"url":28,"identifiers":1926},"Moreno-Bueno, G., Portillo, F. & Cano, A. Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27, 6958–6969 (2008).",{"doi":1927},"10.1038\u002Fonc.2008.346",{"id":28,"text":1929,"url":28,"identifiers":1930},"Yilmaz, M. & Christofori, G. Mechanisms of motility in metastasizing cells. Mol. Cancer Res. 8, 629–642 (2010).",{"doi":1931},"10.1158\u002F1541-7786.MCR-10-0139",{"id":28,"text":1933,"url":28,"identifiers":1934},"Ridley, A. J. Life at the leading edge. Cell 145, 1012–1022 (2011).",{"doi":1935},"10.1016\u002Fj.cell.2011.06.010",{"id":28,"text":1937,"url":28,"identifiers":1938},"McNiven, M. A. Breaking away: matrix remodeling from the leading edge. Trends Cell Biol. 23, 16–21 (2013).",{"doi":1939},"10.1016\u002Fj.tcb.2012.08.009",{"id":28,"text":1941,"url":28,"identifiers":1942},"Haynes, J. Srivastava, J., Madson, N., Wittmann, T. & Barber, D. L. Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol. Biol. Cell 22, 4750–4764 (2011).",{"doi":1943},"10.1091\u002Fmbc.e11-02-0119",{"id":28,"text":1945,"url":28,"identifiers":1946},"Narumiya, S., Tanji, M. & Ishizaki, T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev. 28, 65–76 (2009).",{"doi":1947},"10.1007\u002Fs10555-008-9170-7",{"id":28,"text":1949,"url":28,"identifiers":1950},"Whale, A., Hashim, F. N., Fram, S., Jones, G. E. & Wells, C. M. Signalling to cancer cell invasion through PAK family kinases. Front. Biosci. 16, 849–864 (2011).",{"doi":1951},"10.2741\u002F3724",{"id":28,"text":1953,"url":28,"identifiers":1954},"Anastasiadis, P. Z. & Reynolds, A. B. Regulation of Rho GTPases by p120-catenin. Curr. Opin. Cell Biol. 13, 604–610 (2001).",{"doi":1955},"10.1016\u002FS0955-0674(00)00258-1",{"id":28,"text":1957,"url":28,"identifiers":1958},"Nelson, W. J. Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb. Perspect Biol. 1, a000513 (2009).",{"doi":1959},"10.1101\u002Fcshperspect.a000513",{"id":28,"text":1961,"url":28,"identifiers":1962},"Godde, N. J., Galea, R. C., Elsum, I. A. & Humbert, P. O. Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions. J. Mammary Gland Biol. Neoplasia 15, 149–168 (2010).",{"doi":1963},"10.1007\u002Fs10911-010-9180-2",{"id":28,"text":1965,"url":28,"identifiers":1966},"Wittmann, T., Bokoch, G. M. & Waterman-Storer, C. M. Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J. Cell Biol. 161, 845–851 (2003).",{"doi":1967},"10.1083\u002Fjcb.200303082",{"id":28,"text":1969,"url":28,"identifiers":1970},"Wheelock, M. J., Shintani, Y., Maeda, M., Fukumoto, Y. & Johnson, K. R. Cadherin switching. J. Cell Sci. 121, 727–735 (2008).",{"doi":1971},"10.1242\u002Fjcs.000455",{"id":28,"text":1973,"url":28,"identifiers":1974},"Theveneau, E. & Mayor, R. Cadherins in collective cell migration of mesenchymal cells. Curr. Opin. Cell Biol. 24, 677–684 (2012).",{"doi":1975},"10.1016\u002Fj.ceb.2012.08.002",{"id":28,"text":1977,"url":28,"identifiers":1978},"Brieher, W. M. & Yap, A. S. Cadherin junctions and their cytoskeleton(s). Curr. Opin. Cell Biol. 25, 39–46 (2013).",{"doi":1979},"10.1016\u002Fj.ceb.2012.10.010",{"id":28,"text":1981,"url":28,"identifiers":1982},"Hansen, S. M., Berezin, V. & Bock, E. Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin. Cell. Mol. Life Sci. 65, 3809–3821 (2008).",{"doi":1983},"10.1007\u002Fs00018-008-8290-0",{"id":28,"text":1985,"url":28,"identifiers":1986},"Cavallaro, U. & Christofori, G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nature Rev. Cancer 4, 118–132 (2004).",{"doi":1987},"10.1038\u002Fnrc1276",{"id":28,"text":1989,"url":28,"identifiers":1990},"Lehembre, F. et al. NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin. EMBO J. 27, 2603–2615 (2008).",{"doi":1991},"10.1038\u002Femboj.2008.178",{"id":28,"text":1993,"url":28,"identifiers":1994},"Toivola, D. M., Tao, G. Z., Habtezion, A., Liao, J. & Omary, M. B. Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments. Trends Cell Biol. 15, 608–617 (2005).",{"doi":1995},"10.1016\u002Fj.tcb.2005.09.004",{"id":28,"text":1997,"url":28,"identifiers":1998},"Mendez, M. G., Kojima, S. & Goldman, R. D. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J. 24, 1838–1851 (2010).",{"doi":1999},"10.1096\u002Ffj.09-151639",{"id":28,"text":2001,"url":28,"identifiers":2002},"Yang, X., Pursell, B., Lu, S., Chang, T. K. & Mercurio, A. M. Regulation of β4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J. Cell Sci. 122, 2473–2480 (2009).",{"doi":2003},"10.1242\u002Fjcs.049148",{"id":28,"text":2005,"url":28,"identifiers":2006},"Kim, Y. et al. Integrin α3β1-dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts. J. Cell Biol. 184, 309–322 (2009). Illustrates the crucial role of an integrin, and the remarkable crosstalk and interdependence of signalling systems, in the control of EMT. Loss of a specific integrin impairs E-cadherin turnover and results in dysregulation of TGFβ signalling and β-catenin–SMAD cooperation.",{"doi":2007},"10.1083\u002Fjcb.200806067",{"id":28,"text":2009,"url":28,"identifiers":2010},"Maschler, S. et al. Tumor cell invasiveness correlates with changes in integrin expression and localization. Oncogene 24, 2032–2041 (2005).",{"doi":2011},"10.1038\u002Fsj.onc.1208423",{"id":28,"text":2013,"url":28,"identifiers":2014},"Mise, N. et al. Zyxin is a transforming growth factor-β (TGF-β)\u002FSmad3 target gene that regulates lung cancer cell motility via integrin α5β1. J. Biol. Chem. 287, 31393–31405 (2012).",{"doi":2015},"10.1074\u002Fjbc.M112.357624",{"id":28,"text":2017,"url":28,"identifiers":2018},"Koenig, A., Mueller, C., Hasel, C., Adler, G. & Menke, A. Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. Cancer Res. 66, 4662–4671 (2006).",{"doi":2019},"10.1158\u002F0008-5472.CAN-05-2804",{"id":28,"text":2021,"url":28,"identifiers":2022},"Nistico, P., Bissell, M. J. & Radisky, D. C. Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol 4, a011908 (2012).",{"doi":2023},"10.1101\u002Fcshperspect.a011908",{"id":28,"text":2025,"url":28,"identifiers":2026},"Radisky, D. C. et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436, 123–127 (2005). Provides a remarkable example of how the tumour microenvironment can induce EMT. Exposure of breast epithelial cells to the stromal matrix metalloprotease MMP3 induces the expression of an isoform of the RAC1 GTPase, and, in turn, an increase in cellular reactive oxygen species. This novel pathway activates the expression of SNAIL and the EMT programme.",{"doi":2027},"10.1038\u002Fnature03688",{"id":28,"text":2029,"url":28,"identifiers":2030},"Shah, P. P., Fong, M. Y. & Kakar, S. S. PTTG induces EMT through integrin αvβ3-focal adhesion kinase signaling in lung cancer cells. Oncogene 31, 3124–3135 (2012).",{"doi":2031},"10.1038\u002Fonc.2011.488",{"id":28,"text":2033,"url":28,"identifiers":2034},"Sheppard, D. Integrin-mediated activation of latent transforming growth factor β. Cancer Metastasis Rev. 24, 395–402 (2005).",{"doi":2035},"10.1007\u002Fs10555-005-5131-6",{"id":28,"text":2037,"url":28,"identifiers":2038},"Barrallo-Gimeno, A. & Nieto, M. A. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132, 3151–3161 (2005).",{"doi":2039},"10.1242\u002Fdev.01907",{"id":28,"text":2041,"url":28,"identifiers":2042},"Xu, J., Lamouille, S. & Derynck, R. TGF-β-induced epithelial to mesenchymal transition. Cell Res. 19, 156–172 (2009).",{"doi":2043},"10.1038\u002Fcr.2009.5",{"id":28,"text":2045,"url":28,"identifiers":2046},"Batlle, E. et al. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biol. 2, 84–89 (2000).",{"doi":2047},"10.1038\u002F35000034",{"id":28,"text":2049,"url":28,"identifiers":2050},"Cano, A. et al. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol. 2, 76–83 (2000). References 46 and 47 identify SNAIL as a repressor of E-cadherin expression and demonstrate that it promotes EMT in development and cancer by repressing the E-cadherin promoter.",{"doi":2051},"10.1038\u002F35000025",{"id":28,"text":2053,"url":28,"identifiers":2054},"Lin, T., Ponn, A., Hu, X., Law, B. K. & Lu, J. Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene 29, 4896–4904 (2010).",{"doi":2055},"10.1038\u002Fonc.2010.234",{"id":28,"text":2057,"url":28,"identifiers":2058},"Peinado, H., Ballestar, E., Esteller, M. & Cano, A. Snail mediates E-cadherin repression by the recruitment of the Sin3A\u002Fhistone deacetylase 1 (HDAC1)\u002FHDAC2 complex. Mol. Cell. Biol. 24, 306–319 (2004).",{"doi":2059},"10.1128\u002FMCB.24.1.306-319.2004",{"id":28,"text":2061,"url":28,"identifiers":2062},"Tong, Z. T. et al. EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1\u002FHDAC2 and Snail to inhibit E-cadherin. Oncogene 31, 583–594 (2012).",{"doi":2063},"10.1038\u002Fonc.2011.254",{"id":28,"text":2065,"url":28,"identifiers":2066},"Herranz, N. et al. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol. Cell. Biol. 28, 4772–4781 (2008).",{"doi":2067},"10.1128\u002FMCB.00323-08",{"id":28,"text":2069,"url":28,"identifiers":2070},"Dong, C. et al. Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene 32, 1351–1362 (2013).",{"doi":2071},"10.1038\u002Fonc.2012.169",{"id":28,"text":2073,"url":28,"identifiers":2074},"Dong, C. et al. G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J. Clin. Invest. 122, 1469–1486 (2012). Histone methylation is shown to be crucial in the repression of E-cadherin expression, and in the initiation of EMT. The cooperation of SNAIL with a methyltransferase is shown to be essential in the control of this differentiation programme.",{"doi":2075},"10.1172\u002FJCI57349",{"id":28,"text":2077,"url":28,"identifiers":2078},"Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315–326 (2006).",{"doi":2079},"10.1016\u002Fj.cell.2006.02.041",{"id":28,"text":2081,"url":28,"identifiers":2082},"Xi, Q. et al. A poised chromatin platform for TGF-β access to master regulators. Cell 147, 1511–1524 (2011).",{"doi":2083},"10.1016\u002Fj.cell.2011.11.032",{"id":28,"text":2085,"url":28,"identifiers":2086},"Jorda, M. et al. Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor. J. Cell Sci. 118, 3371–3385 (2005).",{"doi":2087},"10.1242\u002Fjcs.02465",{"id":28,"text":2089,"url":28,"identifiers":2090},"Vincent, T. et al. A SNAIL1-SMAD3\u002F4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition. Nature Cell Biol. 11, 943–950 (2009). This study provides the first evidence at the molecular level for direct cooperation of TGFβ–SMAD signalling with a crucial EMT transcription factor, SNAIL1, in the initiation of EMT.",{"doi":2091},"10.1038\u002Fncb1905",{"id":28,"text":2093,"url":28,"identifiers":2094},"Zhou, B. P. et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nature Cell Biol. 6, 931–940 (2004).",{"doi":2095},"10.1038\u002Fncb1173",{"id":28,"text":2097,"url":28,"identifiers":2098},"Yook, J. I. et al. A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biol. 8, 1398–1406 (2006). Reference 58 and 59 demonstrate, in molecular detail, the regulation of SNAIL1 activity by GSK3β-mediated phosphorylation, and provide insight into the control of EMT by WNT signalling.",{"doi":2099},"10.1038\u002Fncb1508",{"id":28,"text":2101,"url":28,"identifiers":2102},"Sahlgren, C., Gustafsson, M. V., Jin, S., Poellinger, L. & Lendahl, U. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc. Natl Acad. Sci. USA 105, 6392–6397 (2008).",{"doi":2103},"10.1073\u002Fpnas.0802047105",{"id":28,"text":2105,"url":28,"identifiers":2106},"Wu, Y. et al. Stabilization of Snail by NF-κB is required for inflammation-induced cell migration and invasion. Cancer Cell 15, 416–428 (2009).",{"doi":2107},"10.1016\u002Fj.ccr.2009.03.016",{"id":28,"text":2109,"url":28,"identifiers":2110},"Wu, Y., Evers, B. M. & Zhou, B. P. Small C-terminal domain phosphatase enhances snail activity through dephosphorylation. J. Biol. Chem. 284, 640–648 (2009).",{"doi":2111},"10.1074\u002Fjbc.M806916200",{"id":28,"text":2113,"url":28,"identifiers":2114},"Du, C., Zhang, C., Hassan, S., Biswas, M. H. & Balaji, K. C. Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail. Cancer Res. 70, 7810–7819 (2010).",{"doi":2115},"10.1158\u002F0008-5472.CAN-09-4481",{"id":28,"text":2117,"url":28,"identifiers":2118},"Yang, Z. et al. Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res. 65, 3179–3184 (2005).",{"doi":2119},"10.1158\u002F0008-5472.CAN-04-3480",{"id":28,"text":2121,"url":28,"identifiers":2122},"Zhang, K. et al. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J. 31, 29–43 (2012).",{"doi":2123},"10.1038\u002Femboj.2011.357",{"id":28,"text":2125,"url":28,"identifiers":2126},"Wang, S. P. et al. p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nature Cell Biol. 11, 694–704 (2009).",{"doi":2127},"10.1038\u002Fncb1875",{"id":28,"text":2129,"url":28,"identifiers":2130},"Yang, M. H. et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nature Cell Biol. 12, 982–992 (2010). The Polycomb complex protein BMI1, which is required for stem cell self-renewal, is shown to functionally cooperate with the EMT transcription factor TWIST1 in the repression of E-cadherin expression and in EMT. These results illustrate a role for chromatin remodelling in EMT.",{"doi":2131},"10.1038\u002Fncb2099",{"id":28,"text":2133,"url":28,"identifiers":2134},"Yang, M. H. et al. Direct regulation of TWIST by HIF-1α promotes metastasis. Nature Cell Biol. 10, 295–305 (2008).",{"doi":2135},"10.1038\u002Fncb1691",{"id":28,"text":2137,"url":28,"identifiers":2138},"Yang, F. et al. SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO J. 31, 110–123 (2012).",{"doi":2139},"10.1038\u002Femboj.2011.364",{"id":28,"text":2141,"url":28,"identifiers":2142},"Farge, E. Mechanical induction of Twist in the Drosophila foregut\u002Fstomodeal primordium. Curr. Biol. 13, 1365–1377 (2003).",{"doi":2143},"10.1016\u002FS0960-9822(03)00576-1",{"id":28,"text":2145,"url":28,"identifiers":2146},"Kang, Y., Chen, C. R. & Massagué, J. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell 11, 915–926 (2003).",{"doi":2147},"10.1016\u002FS1097-2765(03)00109-6",{"id":28,"text":2149,"url":28,"identifiers":2150},"Hong, J. et al. Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness. Cancer Res. 71, 3980–3990 (2011).",{"doi":2151},"10.1158\u002F0008-5472.CAN-10-2914",{"id":28,"text":2153,"url":28,"identifiers":2154},"Sanchez-Tillo, E. et al. ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI\u002FSNF chromatin-remodeling protein BRG1. Oncogene 29, 3490–3500 (2010).",{"doi":2155},"10.1038\u002Fonc.2010.102",{"id":28,"text":2157,"url":28,"identifiers":2158},"Postigo, A. A., Depp, J. L., Taylor, J. J. & Kroll, K. L. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 22, 2453–2462 (2003).",{"doi":2159},"10.1093\u002Femboj\u002Fcdg226",{"id":28,"text":2161,"url":28,"identifiers":2162},"Wang, J. et al. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446, 882–887 (2007).",{"doi":2163},"10.1038\u002Fnature05671",{"id":28,"text":2165,"url":28,"identifiers":2166},"Dave, N. et al. Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J. Biol. Chem. 286, 12024–12032 (2011).",{"doi":2167},"10.1074\u002Fjbc.M110.168625",{"id":28,"text":2169,"url":28,"identifiers":2170},"Shirakihara, T., Saitoh, M. & Miyazono, K. Differential regulation of epithelial and mesenchymal markers by δEF1 proteins in epithelial mesenchymal transition induced by TGF-β. Mol. Biol. Cell 18, 3533–3544 (2007).",{"doi":2171},"10.1091\u002Fmbc.e07-03-0249",{"id":28,"text":2173,"url":28,"identifiers":2174},"Long, J., Zuo, D. & Park, M. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J. Biol. Chem. 280, 35477–35489 (2005).",{"doi":2175},"10.1074\u002Fjbc.M504477200",{"id":28,"text":2177,"url":28,"identifiers":2178},"Eijkelenboom, A. & Burgering, B. M. FOXOs: signalling integrators for homeostasis maintenance. Nature Rev. Mol. Cell Biol. 14, 83–97 (2013).",{"doi":2179},"10.1038\u002Fnrm3507",{"id":28,"text":2181,"url":28,"identifiers":2182},"Bresnick, E. H., Lee, H. Y., Fujiwara, T., Johnson, K. D. & Keles, S. GATA switches as developmental drivers. J. Biol. Chem. 285, 31087–31093 (2010).",{"doi":2183},"10.1074\u002Fjbc.R110.159079",{"id":28,"text":2185,"url":28,"identifiers":2186},"Campbell, K., Whissell, G., Franch-Marro, X., Batlle, E. & Casanova, J. Specific GATA factors act as conserved inducers of an endodermal-EMT. Dev. Cell 21, 1051–1061 (2011). A GATA transcription factor is found to have a crucial role in the induction of EMT, in Drosophila melanogaster and mammalian cells, through the downregulation of junctional E-cadherin, and repression of expression of the apical–basal polarity complex protein Crumbs.",{"doi":2187},"10.1016\u002Fj.devcel.2011.10.005",{"id":28,"text":2189,"url":28,"identifiers":2190},"Kondoh, H. & Kamachi, Y. SOX-partner code for cell specification: Regulatory target selection and underlying molecular mechanisms. Int. J. Biochem. Cell Biol. 42, 391–399 (2010).",{"doi":2191},"10.1016\u002Fj.biocel.2009.09.003",{"id":28,"text":2193,"url":28,"identifiers":2194},"Sakai, D., Suzuki, T., Osumi, N. & Wakamatsu, Y. Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development. Development 133, 1323–1333 (2006).",{"doi":2195},"10.1242\u002Fdev.02297",{"id":28,"text":2197,"url":28,"identifiers":2198},"Guo, W. et al. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 148, 1015–1028 (2012).",{"doi":2199},"10.1016\u002Fj.cell.2012.02.008",{"id":28,"text":2201,"url":28,"identifiers":2202},"Brown, R. L. et al. CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J. Clin. Invest. 121, 1064–1074 (2011).",{"doi":2203},"10.1172\u002FJCI44540",{"id":28,"text":2205,"url":28,"identifiers":2206},"Shirakihara, T. et al. TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 30, 783–795 (2011). TGFβ is shown to induce a switch in splicing patterns, specifically of FGF receptors, illustrating a role of differential splicing in the control of EMT. This study also highlights the functional crosstalk of TGFβ signalling with RTK signalling through the ERK MAPK pathway in defining the EMT phenotype.",{"doi":2207},"10.1038\u002Femboj.2010.351",{"id":28,"text":2209,"url":28,"identifiers":2210},"Warzecha, C. C., Sato, T. K., Nabet, B., Hogenesch, J. B. & Carstens, R. P. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol. Cell 33, 591–601 (2009).",{"doi":2211},"10.1016\u002Fj.molcel.2009.01.025",{"id":28,"text":2213,"url":28,"identifiers":2214},"Yanagisawa, M. et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease. J. Biol. Chem. 283, 18344–18354 (2008).",{"doi":2215},"10.1074\u002Fjbc.M801192200",{"id":28,"text":2217,"url":28,"identifiers":2218},"Shapiro, I. M. et al. An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet. 7, e1002218 (2011). Documents the extensive changes in splicing patterns that accompany EMT and the key roles of splicing mediators in the control of EMT. Analyses of the alternative splicing signature that defines EMT enable subtype classification of mammary carcinoma cells and tissues.",{"doi":2219},"10.1371\u002Fjournal.pgen.1002218",{"id":28,"text":2221,"url":28,"identifiers":2222},"Warzecha, C. C. et al. An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J. 29, 3286–3300 (2010).",{"doi":2223},"10.1038\u002Femboj.2010.195",{"id":28,"text":2225,"url":28,"identifiers":2226},"Braeutigam, C. et al. The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion. Oncogene http:\u002F\u002Fdx.doi.org\u002F10.1038\u002Fonc.2013.50 (2013).",{"doi":2227},"10.1038\u002Fonc.2013.50",{"id":28,"text":2229,"url":28,"identifiers":2230},"Goncalves, V., Matos, P. & Jordan, P. Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. Hum. Mol. Genet. 18, 3696–3707 (2009).",{"doi":2231},"10.1093\u002Fhmg\u002Fddp317",{"id":28,"text":2233,"url":28,"identifiers":2234},"Valacca, C. et al. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2\u002FASF proto-oncogene. J. Cell Biol. 191, 87–99 (2010).",{"doi":2235},"10.1083\u002Fjcb.201001073",{"id":28,"text":2237,"url":28,"identifiers":2238},"Lamouille, S., Subramanyam, D., Blelloch, R. & Derynck, R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr. Opin. Cell Biol. 25, 200–207 (2013).",{"doi":2239},"10.1016\u002Fj.ceb.2013.01.008",{"id":28,"text":2241,"url":28,"identifiers":2242},"Ru, P. et al. miRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signaling. Mol. Cancer Ther. 11, 1166–1173 (2012).",{"doi":2243},"10.1158\u002F1535-7163.MCT-12-0100",{"id":28,"text":2245,"url":28,"identifiers":2246},"Zhang, J. et al. miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1. Biochem. Biophys. Res. Commun. 417, 1100–1105 (2012).",{"doi":2247},"10.1016\u002Fj.bbrc.2011.12.121",{"id":28,"text":2249,"url":28,"identifiers":2250},"Liu, Y. N. et al. MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms. Oncogene 32, 296–306 (2012). A mutually inhibitory loop, with miR-1 and miR-200 microRNAs repressing SNAIL2 expression, and SNAIL2 repressing miR-1 and miR-200 expression, is described. This double feedback mechanism enables for the gradual amplification of cancer-associated EMT.",{"doi":2251},"10.1038\u002Fonc.2012.58",{"id":28,"text":2253,"url":28,"identifiers":2254},"Siemens, H. et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 10, 4256–4271 (2011).",{"doi":2255},"10.4161\u002Fcc.10.24.18552",{"id":28,"text":2257,"url":28,"identifiers":2258},"Moes, M. et al. A novel network integrating a miRNA-203\u002FSNAI1 feedback loop which regulates epithelial to mesenchymal transition. PLoS ONE 7, e35440 (2012).",{"doi":2259},"10.1371\u002Fjournal.pone.0035440",{"id":28,"text":2261,"url":28,"identifiers":2262},"Gregory, P. A. et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biol. 10, 593–601 (2008). miR-200 and miR-205 microRNAs are shown to repress ZEB1 and ZEB2 expression. They have a crucial role in the progression of EMT, and are able to induce MET.",{"doi":2263},"10.1038\u002Fncb1722",{"id":28,"text":2265,"url":28,"identifiers":2266},"Bracken, C. P. et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 68, 7846–7854 (2008).",{"doi":2267},"10.1158\u002F0008-5472.CAN-08-1942",{"id":28,"text":2269,"url":28,"identifiers":2270},"Kim, T. et al. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J. Exp. Med. 208, 875–883 (2011).",{"doi":2271},"10.1084\u002Fjem.20110235",{"id":28,"text":2273,"url":28,"identifiers":2274},"Thuault, S. et al. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283, 33437–33446 (2008).",{"doi":2275},"10.1074\u002Fjbc.M802016200",{"id":28,"text":2277,"url":28,"identifiers":2278},"Watanabe, S. et al. HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am. J. Pathol. 174, 854–868 (2009).",{"doi":2279},"10.2353\u002Fajpath.2009.080523",{"id":28,"text":2281,"url":28,"identifiers":2282},"Qi, J. et al. MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1. Cell Cycle 11, 177–186 (2012).",{"doi":2283},"10.4161\u002Fcc.11.1.18576",{"id":28,"text":2285,"url":28,"identifiers":2286},"Ma, L. et al. miR-9, a MYC\u002FMYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nature Cell Biol. 12, 247–256 (2010). The miRNA miR-9 represses E-cadherin expression, leading to activation of β-catenin signalling and, consequently, to VEGF expression, thus promoting angiogenesis and metastasis. The expression of this metastasis-promoting miRNA is activated by MYC, and correlates with MYCN amplification, in breast cancers.",{"doi":2287},"10.1038\u002Fncb2024",{"id":28,"text":2289,"url":28,"identifiers":2290},"Song, Y. et al. Inverse association between miR-194 expression and tumor invasion in gastric cancer. Ann. Surg. Oncol. 19 (Suppl. 3), S509–517 (2012).",{"doi":2291},"10.1245\u002Fs10434-011-1999-2",{"id":28,"text":2293,"url":28,"identifiers":2294},"Meng, Z. et al. miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology 52, 2148–2157 (2010).",{"doi":2295},"10.1002\u002Fhep.23915",{"id":28,"text":2297,"url":28,"identifiers":2298},"Zhou, Q. et al. TGF-β-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells. J. Biol. Chem. 285, 40019–40027 (2010).",{"doi":2299},"10.1074\u002Fjbc.M110.141341",{"id":28,"text":2301,"url":28,"identifiers":2302},"Vetter, G. et al. miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers. Oncogene 29, 4436–4448 (2010).",{"doi":2303},"10.1038\u002Fonc.2010.181",{"id":28,"text":2305,"url":28,"identifiers":2306},"Kong, W. et al. MicroRNA-155 is regulated by the transforming growth factor β\u002FSmad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol. Cell. Biol. 28, 6773–6784 (2008).",{"doi":2307},"10.1128\u002FMCB.00941-08",{"id":28,"text":2309,"url":28,"identifiers":2310},"Papadimitriou, E. et al. Differential regulation of the two RhoA-specific GEF isoforms Net1\u002FNet1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition. Oncogene 31, 2862–2875 (2012).",{"doi":2311},"10.1038\u002Fonc.2011.457",{"id":28,"text":2313,"url":28,"identifiers":2314},"Valastyan, S., Chang, A., Benaich, N., Reinhardt, F. & Weinberg, R. A. Concurrent suppression of integrin α5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res. 70, 5147–5154 (2010).",{"doi":2315},"10.1158\u002F0008-5472.CAN-10-0410",{"id":28,"text":2317,"url":28,"identifiers":2318},"Zheng, F. et al. The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 61, 278–289 (2012).",{"doi":2319},"10.1136\u002Fgut.2011.239145",{"id":28,"text":2321,"url":28,"identifiers":2322},"Mercado-Pimentel, M. E. & Runyan, R. B. Multiple transforming growth factor-β isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs 185, 146–156 (2007).",{"doi":2323},"10.1159\u002F000101315",{"id":28,"text":2325,"url":28,"identifiers":2326},"Nawshad, A., LaGamba, D. & Hay, E. D. Transforming growth factor β (TGFβ) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT). Arch. Oral Biol. 49, 675–689 (2004).",{"doi":2327},"10.1016\u002Fj.archoralbio.2004.05.007",{"id":28,"text":2329,"url":28,"identifiers":2330},"Schnaper, H. W., Hayashida, T., Hubchak, S. C. & Poncelet, A. C. TGF-β signal transduction and mesangial cell fibrogenesis. Am. J. Physiol. Renal Physiol. 284, F243–252 (2003).",{"doi":2331},"10.1152\u002Fajprenal.00300.2002",{"id":28,"text":2333,"url":28,"identifiers":2334},"Gressner, A. M., Weiskirchen, R., Breitkopf, K. & Dooley, S. Roles of TGF-β in hepatic fibrosis. Front Biosci. 7, d793–807 (2002).",{"doi":2335},"10.2741\u002FA812",{"id":28,"text":2337,"url":28,"identifiers":2338},"Willis, B. C. & Borok, Z. TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 293, L525–534 (2007).",{"doi":2339},"10.1152\u002Fajplung.00163.2007",{"id":28,"text":2341,"url":28,"identifiers":2342},"Zeisberg, E. M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nature Med. 13, 952–961 (2007). This study illustrates the important pathological contribution of EndMT to fibrosis, and its control by TGFβ family proteins, with TGFβ promoting and BMP7 antagonizing EndMT.",{"doi":2343},"10.1038\u002Fnm1613",{"id":28,"text":2345,"url":28,"identifiers":2346},"Katsuno, Y., Lamouille, S. & Derynck, R. TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Curr. Opin. Oncol. 25, 76–84 (2013).",{"doi":2347},"10.1097\u002FCCO.0b013e32835b6371",{"id":28,"text":2349,"url":28,"identifiers":2350},"Portella, G. et al. Transforming growth factor β is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ. 9, 393–404 (1998).",{},{"id":28,"text":2352,"url":28,"identifiers":2353},"Acloque, H., Adams, M. S., Fishwick, K., Bronner-Fraser, M. & Nieto, M. A. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J. Clin. Invest. 119, 1438–1449 (2009).",{"doi":2354},"10.1172\u002FJCI38019",{"id":28,"text":2356,"url":28,"identifiers":2357},"Sauka-Spengler, T. & Bronner-Fraser, M. A gene regulatory network orchestrates neural crest formation. Nature Rev. Mol. Cell Biol. 9, 557–568 (2008).",{"doi":2358},"10.1038\u002Fnrm2428",{"id":28,"text":2360,"url":28,"identifiers":2361},"Kruithof, B. P., Duim, S. N., Moerkamp, A. T. & Goumans, M. J. TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken. Differentiation 84, 89–102 (2012).",{"doi":2362},"10.1016\u002Fj.diff.2012.04.003",{"id":28,"text":2364,"url":28,"identifiers":2365},"Klattig, J. & Englert, C. The Müllerian duct: recent insights into its development and regression. Sex. Dev. 1, 271–278 (2007).",{"doi":2366},"10.1159\u002F000108929",{"id":28,"text":2368,"url":28,"identifiers":2369},"Gordon, K. J., Kirkbride, K. C., How, T. & Blobe, G. C. Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2. Carcinogenesis 30, 238–248 (2009).",{"doi":2370},"10.1093\u002Fcarcin\u002Fbgn274",{"id":28,"text":2372,"url":28,"identifiers":2373},"Zeisberg, M., Shah, A. A. & Kalluri, R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J. Biol. Chem. 280, 8094–8100 (2005).",{"doi":2374},"10.1074\u002Fjbc.M413102200",{"id":28,"text":2376,"url":28,"identifiers":2377},"Medici, D. et al. Conversion of vascular endothelial cells into multipotent stem-like cells. Nature Med. 16, 1400–1406 (2010). Endothelial cells are shown to convert into mesenchymal cells and acquire stem cell properties, dependent on the TGFβ family receptor ALK2. Lineage tracing suggests an endothelial cell origin of chondrocytes and osteoblasts in heterotypic ossification associated with fibrodysplasia ossificans progressiva.",{"doi":2378},"10.1038\u002Fnm.2252",{"id":28,"text":2380,"url":28,"identifiers":2381},"Feng, X. H. & Derynck, R. Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659–693 (2005).",{"doi":2382},"10.1146\u002Fannurev.cellbio.21.022404.142018",{"id":28,"text":2384,"url":28,"identifiers":2385},"Massagué, J. TGFβ signalling in context. Nature Rev. Mol. Cell Biol. 13, 616–630 (2012).",{"doi":2386},"10.1038\u002Fnrm3434",{"id":28,"text":2388,"url":28,"identifiers":2389},"Miyazono, K., ten Dijke, P. & Heldin, C. H. TGF-β signaling by Smad proteins. Adv. Immunol. 75, 115–157 (2000).",{"doi":2390},"10.1016\u002FS0065-2776(00)75003-6",{"id":28,"text":2392,"url":28,"identifiers":2393},"Valcourt, U., Kowanetz, M., Niimi, H., Heldin, C. H. & Moustakas, A. TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol. Biol. Cell 16, 1987–2002 (2005).",{"doi":2394},"10.1091\u002Fmbc.e04-08-0658",{"id":28,"text":2396,"url":28,"identifiers":2397},"Lamouille, S. & Derynck, R. Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J. Cell Biol. 178, 437–451 (2007). This study illustrates the crucial role of AKT–mTOR signalling in EMT. mTORC1 is required for the increased cell size, cell motility and invasion that accompany EMT.",{"doi":2398},"10.1083\u002Fjcb.200611146",{"id":28,"text":2400,"url":28,"identifiers":2401},"Piek, E., Moustakas, A., Kurisaki, A., Heldin, C. H. & ten Dijke, P. TGF-β type I receptor\u002FALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J. Cell Sci. 112, 4557–4568 (1999).",{"doi":2402},"10.1242\u002Fjcs.112.24.4557",{"id":28,"text":2404,"url":28,"identifiers":2405},"Deckers, M. et al. The tumor suppressor Smad4 is required for transforming growth factor β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res. 66, 2202–2209 (2006).",{"doi":2406},"10.1158\u002F0008-5472.CAN-05-3560",{"id":28,"text":2408,"url":28,"identifiers":2409},"Zavadil, J. & Böttinger, E. P. TGF-β and epithelial-to-mesenchymal transitions. Oncogene 24, 5764–5774 (2005).",{"doi":2410},"10.1038\u002Fsj.onc.1208927",{"id":28,"text":2412,"url":28,"identifiers":2413},"Hoot, K. E. et al. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J. Clin. Invest. 118, 2722–2732 (2008).",{},{"id":28,"text":2415,"url":28,"identifiers":2416},"Ju, W. et al. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol. Cell. Biol. 26, 654–667 (2006).",{"doi":2417},"10.1128\u002FMCB.26.2.654-667.2006",{"id":28,"text":2419,"url":28,"identifiers":2420},"Yang, Y. C. et al. Hierarchical model of gene regulation by transforming growth factor β. Proc. Natl Acad. Sci. USA 100, 10269–10274 (2003).",{"doi":2421},"10.1073\u002Fpnas.1834070100",{"id":28,"text":2423,"url":28,"identifiers":2424},"Morita, T., Mayanagi, T. & Sobue, K. Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. J. Cell Biol. 179, 1027–1042 (2007).",{"doi":2425},"10.1083\u002Fjcb.200708174",{"id":28,"text":2427,"url":28,"identifiers":2428},"Nishimura, G. et al. δEF1 mediates TGF-β signaling in vascular smooth muscle cell differentiation. Dev. Cell 11, 93–104 (2006).",{"doi":2429},"10.1016\u002Fj.devcel.2006.05.011",{"id":28,"text":2431,"url":28,"identifiers":2432},"Postigo, A. A. Opposing functions of ZEB proteins in the regulation of the TGFβ\u002FBMP signaling pathway. EMBO J. 22, 2443–2452 (2003).",{"doi":2433},"10.1093\u002Femboj\u002Fcdg225",{"id":28,"text":2435,"url":28,"identifiers":2436},"Thuault, S. et al. Transforming growth factor-β employs HMGA2 to elicit epithelial-mesenchymal transition. J. Cell Biol. 174, 175–183 (2006).",{"doi":2437},"10.1083\u002Fjcb.200512110",{"id":28,"text":2439,"url":28,"identifiers":2440},"Zavadil, J. et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-β. Proc. Natl Acad. Sci. USA 98, 6686–6691 (2001).",{"doi":2441},"10.1073\u002Fpnas.111614398",{"id":28,"text":2443,"url":28,"identifiers":2444},"Nawshad, A., Medici, D., Liu, C. C. & Hay, E. D. TGFβ3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex. J. Cell Sci. 120, 1646–1653 (2007).",{"doi":2445},"10.1242\u002Fjcs.003129",{"id":28,"text":2447,"url":28,"identifiers":2448},"Kaimori, A. et al. Transforming growth factor-β1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J. Biol. Chem. 282, 22089–22101 (2007).",{"doi":2449},"10.1074\u002Fjbc.M700998200",{"id":28,"text":2451,"url":28,"identifiers":2452},"Derynck, R. & Zhang, Y. E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425, 577–584 (2003).",{"doi":2453},"10.1038\u002Fnature02006",{"id":28,"text":2455,"url":28,"identifiers":2456},"Moustakas, A. & Heldin, C. H. Non-Smad TGF-β signals. J. Cell Sci. 118, 3573–3584 (2005).",{"doi":2457},"10.1242\u002Fjcs.02554",{"id":28,"text":2459,"url":28,"identifiers":2460},"Lamouille, S. & Derynck, R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition. Cells Tissues Organs 193, 8–22 (2011).",{"doi":2461},"10.1159\u002F000320172",{"id":28,"text":2463,"url":28,"identifiers":2464},"Ozdamar, B. et al. Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science 307, 1603–1609 (2005). TGFβ signalling is shown to confer a highly localized effect in epithelial cells, inducing RHOA degradation at tight junctions, thus contributing to epithelial disassembly and EMT.",{"doi":2465},"10.1126\u002Fscience.1105718",{"id":28,"text":2467,"url":28,"identifiers":2468},"Bhowmick, N. A. et al. Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell 12, 27–36 (2001).",{"doi":2469},"10.1091\u002Fmbc.12.1.27",{"id":28,"text":2471,"url":28,"identifiers":2472},"Shen, X. et al. The activity of guanine exchange factor NET1 is essential for transforming growth factor-β-mediated stress fiber formation. J. Biol. Chem. 276, 15362–15368 (2001).",{"doi":2473},"10.1074\u002Fjbc.M009534200",{"id":28,"text":2475,"url":28,"identifiers":2476},"Vardouli, L., Moustakas, A. & Stournaras, C. LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-β. J. Biol. Chem. 280, 11448–11457 (2005).",{"doi":2477},"10.1074\u002Fjbc.M402651200",{"id":28,"text":2479,"url":28,"identifiers":2480},"Tavares, A. L., Mercado-Pimentel, M. E., Runyan, R. B. & Kitten, G. T. TGF β-mediated RhoA expression is necessary for epithelial-mesenchymal transition in the embryonic chick heart. Dev. Dyn. 235, 1589–1598 (2006).",{"doi":2481},"10.1002\u002Fdvdy.20771",{"id":28,"text":2483,"url":28,"identifiers":2484},"Tsapara, A. et al. The RhoA activator GEF-H1\u002FLfc is a transforming growth factor-β target gene and effector that regulates α-smooth muscle actin expression and cell migration. Mol. Biol. Cell 21, 860–870 (2010).",{"doi":2485},"10.1091\u002Fmbc.e09-07-0567",{"id":28,"text":2487,"url":28,"identifiers":2488},"Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A., Moses, H. L. & Arteaga, C. L. Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem. 275, 36803–36810 (2000).",{"doi":2489},"10.1074\u002Fjbc.M005912200",{"id":28,"text":2491,"url":28,"identifiers":2492},"Lamouille, S., Connolly, E., Smyth, J. W., Akhurst, R. J. & Derynck, R. TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J. Cell Sci. 125, 1259–1273 (2012). This study, together with reference 134, illustrates the crucial role of AKT–mTOR signalling in EMT. mTORC2 is required for the transition from the epithelial to the mesenchymal phenotype.",{"doi":2493},"10.1242\u002Fjcs.095299",{"id":28,"text":2495,"url":28,"identifiers":2496},"Julien, S. et al. Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26, 7445–7456 (2007).",{"doi":2497},"10.1038\u002Fsj.onc.1210546",{"id":28,"text":2499,"url":28,"identifiers":2500},"Bachelder, R. E., Yoon, S. O., Franci, C., de Herreros, A. G. & Mercurio, A. M. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J. Cell Biol. 168, 29–33 (2005).",{"doi":2501},"10.1083\u002Fjcb.200409067",{"id":28,"text":2503,"url":28,"identifiers":2504},"Chaudhury, A. et al. TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nature Cell Biol. 12, 286–293 (2010). Uncovers a TGFβ-induced translational control mechanism that contributes to EMT. Phosphorylation of hnRNPE1 by AKT derepresses select target mRNAs, resulting in translational activation of DAB2 and ILEI, which are required for EMT.",{"doi":2505},"10.1038\u002Fncb2029",{"id":28,"text":2507,"url":28,"identifiers":2508},"Kang, J. S., Liu, C. & Derynck, R. New regulatory mechanisms of TGF-β receptor function. Trends Cell Biol. 19, 385–394 (2009).",{"doi":2509},"10.1016\u002Fj.tcb.2009.05.008",{"id":28,"text":2511,"url":28,"identifiers":2512},"Lee, M. K. et al. TGF-β activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 26, 3957–3967 (2007).",{"doi":2513},"10.1038\u002Fsj.emboj.7601818",{"id":28,"text":2515,"url":28,"identifiers":2516},"Yamashita, M. et al. TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β. Mol. Cell 31, 918–924 (2008).",{"doi":2517},"10.1016\u002Fj.molcel.2008.09.002",{"id":28,"text":2519,"url":28,"identifiers":2520},"Sorrentino, A. et al. The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nature Cell Biol. 10, 1199–1207 (2008).",{"doi":2521},"10.1038\u002Fncb1780",{"id":28,"text":2523,"url":28,"identifiers":2524},"Xie, L. et al. Activation of the Erk pathway is required for TGF-β1-induced EMT in vitro. Neoplasia 6, 603–610 (2004).",{"doi":2525},"10.1593\u002Fneo.04241",{"id":28,"text":2527,"url":28,"identifiers":2528},"Yu, L., Hébert, M. C. & Zhang, Y. E. TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses. EMBO J. 21, 3749–3759 (2002).",{"doi":2529},"10.1093\u002Femboj\u002Fcdf366",{"id":28,"text":2531,"url":28,"identifiers":2532},"Grande, M. et al. Transforming growth factor-β and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. J. Cell Sci. 115, 4227–4236 (2002).",{"doi":2533},"10.1242\u002Fjcs.00091",{"id":28,"text":2535,"url":28,"identifiers":2536},"Uttamsingh, S. et al. Synergistic effect between EGF and TGF-β1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 27, 2626–2634 (2008).",{"doi":2537},"10.1038\u002Fsj.onc.1210915",{"id":28,"text":2539,"url":28,"identifiers":2540},"Marchetti, A. et al. ERK5\u002FMAPK is activated by TGFβ in hepatocytes and required for the GSK-3β-mediated Snail protein stabilization. Cell Signal 20, 2113–2118 (2008).",{"doi":2541},"10.1016\u002Fj.cellsig.2008.08.002",{"id":28,"text":2543,"url":28,"identifiers":2544},"Sano, Y. et al. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-β signaling. J. Biol. Chem. 274, 8949–8957 (1999).",{"doi":2545},"10.1074\u002Fjbc.274.13.8949",{"id":28,"text":2547,"url":28,"identifiers":2548},"Santibanez, J. F. JNK mediates TGF-β1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett. 580, 5385–5391 (2006).",{"doi":2549},"10.1016\u002Fj.febslet.2006.09.003",{"id":28,"text":2551,"url":28,"identifiers":2552},"Stoker, M. & Perryman, M. An epithelial scatter factor released by embryo fibroblasts. J. Cell Sci. 77, 209–223 (1985).",{"doi":2553},"10.1242\u002Fjcs.77.1.209",{"id":28,"text":2555,"url":28,"identifiers":2556},"Gulhati, P. et al. mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res. 71, 3246–3256 (2011).",{"doi":2557},"10.1158\u002F0008-5472.CAN-10-4058",{"id":28,"text":2559,"url":28,"identifiers":2560},"Makrodouli, E. et al. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. Mol. Cancer 10, 118 (2011).",{"doi":2561},"10.1186\u002F1476-4598-10-118",{"id":28,"text":2563,"url":28,"identifiers":2564},"Doehn, U. et al. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile\u002Finvasive gene program and phenotype in epithelial cells. Mol. Cell 35, 511–522 (2009). Highlights a key contribution of the RAS–ERK MAPK pathway to EMT. The ERK MAPK-activated protein 90 kDa ribosomal protein S6 kinase is required for the induction of motile and invasive behaviour of epithelial and carcinoma cells following mesenchymal transition, through the induction of defined genes.",{"doi":2565},"10.1016\u002Fj.molcel.2009.08.002",{"id":28,"text":2567,"url":28,"identifiers":2568},"Valles, A. M., Boyer, B., Tarone, G. & Thiery, J. P. α2β1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line. Cell Adhes. Commun. 4, 187–199 (1996).",{"doi":2569},"10.3109\u002F15419069609014222",{"id":28,"text":2571,"url":28,"identifiers":2572},"Savagner, P., Yamada, K. M. & Thiery, J. P. The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol. 137, 1403–1419 (1997).",{"doi":2573},"10.1083\u002Fjcb.137.6.1403",{"id":28,"text":2575,"url":28,"identifiers":2576},"Billottet, C. et al. Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells. J. Cell Biochem. 104, 826–839 (2008).",{"doi":2577},"10.1002\u002Fjcb.21667",{"id":28,"text":2579,"url":28,"identifiers":2580},"Ciruna, B. & Rossant, J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev. Cell 1, 37–49 (2001).",{"doi":2581},"10.1016\u002FS1534-5807(01)00017-X",{"id":28,"text":2583,"url":28,"identifiers":2584},"Sun, X., Meyers, E. N., Lewandoski, M. & Martin, G. R. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 13, 1834–1846 (1999).",{"doi":2585},"10.1101\u002Fgad.13.14.1834",{"id":28,"text":2587,"url":28,"identifiers":2588},"Grotegut, S., von Schweinitz, D., Christofori, G. & Lehembre, F. Hepatocyte growth factor induces cell scattering through MAPK\u002FEgr-1-mediated upregulation of Snail. EMBO J. 25, 3534–3545 (2006).",{"doi":2589},"10.1038\u002Fsj.emboj.7601213",{"id":28,"text":2591,"url":28,"identifiers":2592},"Hiscox, S. & Jiang, W. G. Association of the HGF\u002FSF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells. Biochem. Biophys. Res. Commun. 261, 406–411 (1999).",{"doi":2593},"10.1006\u002Fbbrc.1999.1002",{"id":28,"text":2595,"url":28,"identifiers":2596},"Romano, L. A. & Runyan, R. B. Slug is an essential target of TGFβ2 signaling in the developing chicken heart. Dev. Biol. 223, 91–102 (2000).",{"doi":2597},"10.1006\u002Fdbio.2000.9750",{"id":28,"text":2599,"url":28,"identifiers":2600},"Kim, H. J. et al. Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-κB and Snail. Mol. Cell. Biol. 27, 3165–3175 (2007).",{"doi":2601},"10.1128\u002FMCB.01315-06",{"id":28,"text":2603,"url":28,"identifiers":2604},"Graham, T. R. et al. Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res. 68, 2479–2488 (2008).",{"doi":2605},"10.1158\u002F0008-5472.CAN-07-2559",{"id":28,"text":2607,"url":28,"identifiers":2608},"Irie, H. Y. et al. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J. Cell Biol. 171, 1023–1034 (2005).",{"doi":2609},"10.1083\u002Fjcb.200505087",{"id":28,"text":2611,"url":28,"identifiers":2612},"Canonici, A. et al. Insulin-like growth factor-I receptor, E-cadherin and αv integrin form a dynamic complex under the control of α-catenin. Int. J. Cancer 122, 572–582 (2008).",{"doi":2613},"10.1002\u002Fijc.23164",{"id":28,"text":2615,"url":28,"identifiers":2616},"Lu, Z., Ghosh, S., Wang, Z. & Hunter, T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 4, 499–515 (2003).",{"doi":2617},"10.1016\u002FS1535-6108(03)00304-0",{"id":28,"text":2619,"url":28,"identifiers":2620},"Lo, H. W. et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 67, 9066–9076 (2007).",{"doi":2621},"10.1158\u002F0008-5472.CAN-07-0575",{"id":28,"text":2623,"url":28,"identifiers":2624},"Ahmed, N. et al. Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium. Am. J. Physiol. Cell Physiol. 290, C1532–1542 (2006).",{"doi":2625},"10.1152\u002Fajpcell.00478.2005",{"id":28,"text":2627,"url":28,"identifiers":2628},"Moody, S. E. et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8, 197–209 (2005).",{"doi":2629},"10.1016\u002Fj.ccr.2005.07.009",{"id":28,"text":2631,"url":28,"identifiers":2632},"Knutson, K. L. et al. Immunoediting of cancers may lead to epithelial to mesenchymal transition. J. Immunol. 177, 1526–1533 (2006).",{"doi":2633},"10.4049\u002Fjimmunol.177.3.1526",{"id":28,"text":2635,"url":28,"identifiers":2636},"Rangel, M. C. et al. Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer. Am. J. Pathol. 180, 2188–2200 (2012).",{"doi":2637},"10.1016\u002Fj.ajpath.2012.02.031",{"id":28,"text":2639,"url":28,"identifiers":2640},"Strizzi, L. et al. Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice. J. Cell. Physiol. 201, 266–276 (2004).",{"doi":2641},"10.1002\u002Fjcp.20062",{"id":28,"text":2643,"url":28,"identifiers":2644},"Morkel, M. et al. β-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 130, 6283–6294 (2003).",{"doi":2645},"10.1242\u002Fdev.00859",{"id":28,"text":2647,"url":28,"identifiers":2648},"Tao, Q. et al. Maternal Wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120, 857–871 (2005).",{"doi":2649},"10.1016\u002Fj.cell.2005.01.013",{"id":28,"text":2651,"url":28,"identifiers":2652},"Yang, L., Lin, C. & Liu, Z. R. p68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell 127, 139–155 (2006). In PDGF-induced EMT, tyrosine phosphorylation of the RNA helicase p68 is shown to promote the nuclear translocation of β-catenin through a WNT-independent pathway. Nuclear import of β-catenin and its cooperation with TCF\u002FLEF transcription factors are required for EMT.",{"doi":2653},"10.1016\u002Fj.cell.2006.08.036",{"id":28,"text":2655,"url":28,"identifiers":2656},"Robbins, J. R., McGuire, P. G., Wehrle-Haller, B. & Rogers, S. L. Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration. Dev. Biol. 212, 255–263 (1999).",{"doi":2657},"10.1006\u002Fdbio.1999.9373",{"id":28,"text":2659,"url":28,"identifiers":2660},"Wanami, L. S., Chen, H. Y., Peiro, S., Garcia de Herreros, A. & Bachelder, R. E. Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression. Exp. Cell Res. 314, 2448–2453 (2008).",{"doi":2661},"10.1016\u002Fj.yexcr.2008.05.004",{"id":28,"text":2663,"url":28,"identifiers":2664},"Yang, A. D. et al. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res. 66, 46–51 (2006).",{"doi":2665},"10.1158\u002F0008-5472.CAN-05-3086",{"id":28,"text":2667,"url":28,"identifiers":2668},"Peinado, H. et al. Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J. Cell Sci. 117, 2827–2839 (2004).",{"doi":2669},"10.1242\u002Fjcs.01145",{"id":28,"text":2671,"url":28,"identifiers":2672},"Liu, P. et al. Requirement for Wnt3 in vertebrate axis formation. Nature Genet. 22, 361–365 (1999).",{"doi":2673},"10.1038\u002F11932",{"id":28,"text":2675,"url":28,"identifiers":2676},"Popperl, H. et al. Misexpression of Wnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm. Development 124, 2997–3005 (1997).",{"doi":2677},"10.1242\u002Fdev.124.15.2997",{"id":28,"text":2679,"url":28,"identifiers":2680},"Garcia-Castro, M. I., Marcelle, C. & Bronner-Fraser, M. Ectodermal Wnt function as a neural crest inducer. Science 297, 848–851 (2002).",{"doi":2681},"10.1126\u002Fscience.1070824",{"id":28,"text":2683,"url":28,"identifiers":2684},"Carmona-Fontaine, C. et al. Contact inhibition of locomotion in vivo controls neural crest directional migration. Nature 456, 957–961 (2008).",{"doi":2685},"10.1038\u002Fnature07441",{"id":28,"text":2687,"url":28,"identifiers":2688},"Brabletz, T. et al. Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc. Natl Acad. Sci. USA 98, 10356–10361 (2001).",{"doi":2689},"10.1073\u002Fpnas.171610498",{"id":28,"text":2691,"url":28,"identifiers":2692},"Briscoe, J. & Therond, P. P. The mechanisms of Hedgehog signalling and its roles in development and disease. Nature Rev. Mol. Cell Biol. 14, 416–429 (2013).",{"doi":2693},"10.1038\u002Fnrm3598",{"id":28,"text":2695,"url":28,"identifiers":2696},"Monsoro-Burq, A. H. Sclerotome development and morphogenesis: when experimental embryology meets genetics. Int. J. Dev. Biol. 49, 301–308 (2005).",{"doi":2697},"10.1387\u002Fijdb.041953am",{"id":28,"text":2699,"url":28,"identifiers":2700},"Li, X. et al. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene 25, 609–621 (2006).",{"doi":2701},"10.1038\u002Fsj.onc.1209077",{"id":28,"text":2703,"url":28,"identifiers":2704},"Fendrich, V. et al. Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum. Endocr. Relat. Cancer 14, 865–874 (2007).",{"doi":2705},"10.1677\u002FERC-07-0108",{"id":28,"text":2707,"url":28,"identifiers":2708},"Hori, K., Sen, A. & Artavanis-Tsakonas, S. Notch signaling at a glance. J. Cell Sci. 126, 2135–2140 (2013).",{"doi":2709},"10.1242\u002Fjcs.127308",{"id":28,"text":2711,"url":28,"identifiers":2712},"Timmerman, L. A. et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 18, 99–115 (2004).",{"doi":2713},"10.1101\u002Fgad.276304",{"id":28,"text":2715,"url":28,"identifiers":2716},"Niessen, K. et al. Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol. 182, 315–325 (2008).",{"doi":2717},"10.1083\u002Fjcb.200710067",{"id":28,"text":2719,"url":28,"identifiers":2720},"Xie, M. et al. Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells. J. Cell Biochem. 113, 1501–1513 (2012).",{"doi":2721},"10.1002\u002Fjcb.24019",{"id":28,"text":2723,"url":28,"identifiers":2724},"Imai, T. et al. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am. J. Pathol. 163, 1437–1447 (2003).",{"doi":2725},"10.1016\u002FS0002-9440(10)63501-8",{"id":28,"text":2727,"url":28,"identifiers":2728},"Luo, D., Wang, J., Li, J. & Post, M. Mouse Snail is a target gene for HIF. Mol. Cancer Res. 9, 234–245 (2011).",{"doi":2729},"10.1158\u002F1541-7786.MCR-10-0214",{"id":28,"text":2731,"url":28,"identifiers":2732},"Sullivan, N. J. et al. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 28, 2940–2947 (2009).",{"doi":2733},"10.1038\u002Fonc.2009.180",{"id":28,"text":2735,"url":28,"identifiers":2736},"Yadav, A., Kumar, B., Datta, J., Teknos, T. N. & Kumar, P. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway. Mol. Cancer Res. 9, 1658–1667 (2011).",{"doi":2737},"10.1158\u002F1541-7786.MCR-11-0271",{"id":28,"text":2739,"url":28,"identifiers":2740},"Fernando, R. I., Castillo, M. D., Litzinger, M., Hamilton, D. H. & Palena, C. IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res. 71, 5296–5306 (2011).",{"doi":2741},"10.1158\u002F0008-5472.CAN-11-0156",{"id":28,"text":2743,"url":28,"identifiers":2744},"Jing, Y., Han, Z., Zhang, S., Liu, Y. & Wei, L. Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci. 1, 29 (2011).",{"doi":2745},"10.1186\u002F2045-3701-1-29",{"id":28,"text":2747,"url":28,"identifiers":2748},"Heisenberg, C. P. & Solnica-Krezel, L. Back and forth between cell fate specification and movement during vertebrate gastrulation. Curr. Opin. Genet. Dev. 18, 311–316 (2008).",{"doi":2749},"10.1016\u002Fj.gde.2008.07.011",{"id":28,"text":2751,"url":28,"identifiers":2752},"Wendt, M. K., Smith, J. A. & Schiemann, W. P. Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene 29, 6485–6498 (2010).",{"doi":2753},"10.1038\u002Fonc.2010.377",{"id":28,"text":2755,"url":28,"identifiers":2756},"Yang, J., Dai, C. & Liu, Y. A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J. Am. Soc. Nephrol. 16, 68–78 (2005).",{"doi":2757},"10.1681\u002FASN.2003090795",{"id":28,"text":2759,"url":28,"identifiers":2760},"Aragon, E. et al. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 25, 1275–1288 (2011).",{"doi":2761},"10.1101\u002Fgad.2060811",{"id":28,"text":2763,"url":28,"identifiers":2764},"Fuentealba, L. C. et al. Integrating patterning signals: Wnt\u002FGSK3 regulates the duration of the BMP\u002FSmad1 signal. Cell 131, 980–993 (2007).",{"doi":2765},"10.1016\u002Fj.cell.2007.09.027",{"id":28,"text":2767,"url":28,"identifiers":2768},"Grego-Bessa, J., Diez, J., Timmerman, L. & de la Pompa, J. L. Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw. Cell Cycle 3, 718–721 (2004).",{"doi":2769},"10.4161\u002Fcc.3.6.949",{"id":28,"text":2771,"url":28,"identifiers":2772},"Zavadil, J., Cermak, L., Soto-Nieves, N. & Bottinger, E. P. Integration of TGF-β\u002FSmad and Jagged1\u002FNotch signalling in epithelial-to-mesenchymal transition. EMBO J. 23, 1155–1165 (2004).",{"doi":2773},"10.1038\u002Fsj.emboj.7600069",{"id":28,"text":2775,"url":28,"identifiers":2776},"Eastham, A. M. et al. Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res. 67, 11254–11262 (2007).",{"doi":2777},"10.1158\u002F0008-5472.CAN-07-2253",{"id":28,"text":2779,"url":28,"identifiers":2780},"Ullmann, U. et al. Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions. Mol. Hum. Reprod. 13, 21–32 (2007).",{"doi":2781},"10.1093\u002Fmolehr\u002Fgal091",{"id":28,"text":2783,"url":28,"identifiers":2784},"Mikkelsen, T. S. et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 454, 49–55 (2008).",{"doi":2785},"10.1038\u002Fnature07056",{"id":28,"text":2787,"url":28,"identifiers":2788},"Esteban, M. A. et al. The mesenchymal-to-epithelial transition in somatic cell reprogramming. Curr. Opin. Genet. Dev. 22, 423–428 (2012).",{"doi":2789},"10.1016\u002Fj.gde.2012.09.004",{"id":28,"text":2791,"url":28,"identifiers":2792},"Maherali, N. & Hochedlinger, K. TGFβ signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr. Biol. 19, 1718–1723 (2009).",{"doi":2793},"10.1016\u002Fj.cub.2009.08.025",{"id":28,"text":2795,"url":28,"identifiers":2796},"Samavarchi-Tehrani, P. et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 7, 64–77 (2010). Illustrates the key roles of MET and BMP signalling in the reprogramming of somatic cells towards induced pluripotency, and identifies BMP-dependent induction of select miRNAs as a key regulatory axis in the initiation of MET.",{"doi":2797},"10.1016\u002Fj.stem.2010.04.015",{"id":28,"text":2799,"url":28,"identifiers":2800},"Subramanyam, D. et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nature Biotech. 29, 443–448 (2011). The miR-302 and miR-372 miRNAs are shown to promote MET during reprogramming of human fibroblasts into pluripotent cells, and to inhibit TGFβ-induced EMT of human keratinocytes, partly through inhibition of targets that promote EMT.",{"doi":2801},"10.1038\u002Fnbt.1862",{"id":28,"text":2803,"url":28,"identifiers":2804},"Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704–715 (2008). Provides the first direct link between EMT and gain of epithelial stem cell properties. Induction of EMT in normal and malignant mammary epithelial cells results in the acquisition of stem cell-like characteristics.",{"doi":2805},"10.1016\u002Fj.cell.2008.03.027",{"id":28,"text":2807,"url":28,"identifiers":2808},"Scheel, C. & Weinberg, R. A. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin. Cancer Biol. 22, 396–403 (2012). This thoughtful review conceptualizes the roles of the phenotypic plasticity associated with EMT in cancer cell behaviour and cancer progression.",{"doi":2809},"10.1016\u002Fj.semcancer.2012.04.001",{"id":28,"text":2811,"url":28,"identifiers":2812},"Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nature Rev. Cancer 5, 744–749 (2005).",{"doi":2813},"10.1038\u002Fnrc1694",{"id":28,"text":2815,"url":28,"identifiers":2816},"Shipitsin, M. et al. Molecular definition of breast tumor heterogeneity. Cancer Cell 11, 259–273 (2007).",{"doi":2817},"10.1016\u002Fj.ccr.2007.01.013",{"id":28,"text":2819,"url":28,"identifiers":2820},"Vermeulen, L. et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nature Cell Biol. 12, 468–476 (2010).",{"doi":2821},"10.1038\u002Fncb2048",{"id":28,"text":2823,"url":28,"identifiers":2824},"Brabletz, T. et al. Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol. Res. Pract. 194, 701–704 (1998).",{"doi":2825},"10.1016\u002FS0344-0338(98)80129-5",{"id":28,"text":2827,"url":28,"identifiers":2828},"Espinoza, I., Pochampally, R., Xing, F., Watabe, K. & Miele, L. Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition. Onco Targets Ther. 6, 1249–1259 (2013).",{},{"id":28,"text":2830,"url":28,"identifiers":2831},"Ma, J., Xia, J., Miele, L., Sarkar, F. H. & Wang, Z. Notch signaling pathway in pancreatic cancer progression. Pancreat. Disord. Ther. 3, (2013).",{"doi":2832},"10.4172\u002F2165-7092.1000114",{"id":28,"text":2834,"url":28,"identifiers":2835},"Palagani, V. et al. Epithelial mesenchymal transition and pancreatic tumor initiating CD44+\u002FEpCAM+ cells are inhibited by γ-secretase inhibitor IX. PLoS ONE 7, e46514 (2012).",{"doi":2836},"10.1371\u002Fjournal.pone.0046514",{"id":28,"text":2838,"url":28,"identifiers":2839},"Smith, A. L. et al. The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene 31, 5162–5171 (2012).",{"doi":2840},"10.1038\u002Fonc.2012.11",{"id":28,"text":2842,"url":28,"identifiers":2843},"Li, Z., Yang, C. S., Nakashima, K. & Rana, T. M. Small RNA-mediated regulation of iPS cell generation. EMBO J. 30, 823–834 (2011).",{"doi":2844},"10.1038\u002Femboj.2011.2",{"id":28,"text":2846,"url":28,"identifiers":2847},"Medici, D. & Kalluri, R. Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype. Semin. Cancer Biol. 22, 379–384 (2012).",{"doi":2848},"10.1016\u002Fj.semcancer.2012.04.004",{"id":28,"text":2850,"url":28,"identifiers":2851},"van Meeteren, L. A. & ten Dijke, P. Regulation of endothelial cell plasticity by TGF-β. Cell Tissue Res. 347, 177–186 (2012).",{"doi":2852},"10.1007\u002Fs00441-011-1222-6",{"id":28,"text":2854,"url":28,"identifiers":2855},"von Gise, A. & Pu, W. T. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ. Res. 110, 1628–1645 (2012).",{"doi":2856},"10.1161\u002FCIRCRESAHA.111.259960",{"id":28,"text":2858,"url":28,"identifiers":2859},"Zeisberg, E. M., Potenta, S., Xie, L., Zeisberg, M. & Kalluri, R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 67, 10123–10128 (2007). Provides evidence that endothelial conversion into mesenchymal cells substantially contributes to the generation of carcinoma-associated stromal fibroblasts.",{"doi":2860},"10.1158\u002F0008-5472.CAN-07-3127",{"id":28,"text":2862,"url":28,"identifiers":2863},"Medici, D. & Olsen, B. R. The role of endothelial-mesenchymal transition in heterotopic ossification. J. Bone Miner. Res. 27, 1619–1622 (2012).",{"doi":2864},"10.1002\u002Fjbmr.1691",{"id":28,"text":2866,"url":28,"identifiers":2867},"Kokudo, T. et al. Snail is required for TGFβ-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J. Cell Sci. 121, 3317–3324 (2008).",{"doi":2868},"10.1242\u002Fjcs.028282",{"id":28,"text":2870,"url":28,"identifiers":2871},"Luna-Zurita, L. et al. Integration of a Notch-dependent mesenchymal gene program and BMP2-driven cell invasiveness regulates murine cardiac valve formation. J. Clin. Invest. 120, 3493–3507 (2010).",{"doi":2872},"10.1172\u002FJCI42666",{"id":28,"text":2874,"url":28,"identifiers":2875},"Medici, D., Potenta, S. & Kalluri, R. Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochem. J. 437, 515–520 (2011).",{"doi":2876},"10.1042\u002FBJ20101500",{"id":28,"text":2878,"url":28,"identifiers":2879},"Rivera-Feliciano, J. et al. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133, 3607–3618 (2006).",{"doi":2880},"10.1242\u002Fdev.02519",{"id":28,"text":2882,"url":28,"identifiers":2883},"Quaggin, S. E. & Kapus, A. Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition. Kidney Int. 80, 41–50 (2011).",{"doi":2884},"10.1038\u002Fki.2011.77",{"id":28,"text":2886,"url":28,"identifiers":2887},"Radisky, D. C., Kenny, P. A. & Bissell, M. J. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J. Cell Biochem. 101, 830–839 (2007).",{"doi":2888},"10.1002\u002Fjcb.21186",{"id":28,"text":2890,"url":28,"identifiers":2891},"Qiu, P. et al. Myocardin enhances Smad3-mediated transforming growth factor-β1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ. Res. 97, 983–991 (2005).",{"doi":2892},"10.1161\u002F01.RES.0000190604.90049.71",{"id":28,"text":2894,"url":28,"identifiers":2895},"Mihira, H. et al. TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. J. Biochem. 151, 145–156 (2012).",{"doi":2896},"10.1093\u002Fjb\u002Fmvr121",{"id":28,"text":2898,"url":28,"identifiers":2899},"Masszi, A. et al. Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J. Cell Biol. 188, 383–399 (2010).",{"doi":2900},"10.1083\u002Fjcb.200906155",{"id":28,"text":2902,"url":28,"identifiers":2903},"Charbonney, E. Speight, P., Masszi, A., Nakano, H. & Kapus, A. β-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition. Mol. Biol. Cell 22, 4472–4485 (2011).",{"doi":2904},"10.1091\u002Fmbc.e11-04-0335",{"id":28,"text":2906,"url":28,"identifiers":2907},"Lim, J. & Thiery, J. P. Epithelial-mesenchymal transitions: insights from development. Development 139, 3471–3486 (2012).",{"doi":2908},"10.1242\u002Fdev.071209",{"id":28,"text":2910,"url":28,"identifiers":2911},"Zeisberg, M. & Kalluri, R. Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am. J. Physiol. Cell Physiol. 304, C216–225 (2013).",{"doi":2912},"10.1152\u002Fajpcell.00328.2012",{"id":28,"text":2914,"url":28,"identifiers":2915},"Chaffer, C. L., Thompson, E. W. & Williams, E. D. Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 185, 7–19 (2007).",{"doi":2916},"10.1159\u002F000101298",{"id":28,"text":2918,"url":28,"identifiers":2919},"Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011).",{"doi":2920},"10.1016\u002Fj.cell.2011.02.013",{"id":28,"text":2922,"url":28,"identifiers":2923},"Cheung, M. et al. The transcriptional control of trunk neural crest induction, survival, and delamination. Dev. Cell 8, 179–192 (2005).",{"doi":2924},"10.1016\u002Fj.devcel.2004.12.010",{"id":28,"text":2926,"url":28,"identifiers":2927},"Mani, S. A. et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc. Natl Acad. Sci. USA 104, 10069–10074 (2007).",{"doi":2928},"10.1073\u002Fpnas.0703900104",{"id":28,"text":2930,"url":28,"identifiers":2931},"Nilsson, J. et al. Nuclear Janus-activated kinase 2\u002Fnuclear factor 1-C2 suppresses tumorigenesis and epithelial-to-mesenchymal transition by repressing Forkhead box F1. Cancer Res. 70, 2020–2029 (2010).",{"doi":2932},"10.1158\u002F0008-5472.CAN-09-1677",{"id":28,"text":2934,"url":28,"identifiers":2935},"Qiao, Y. et al. FOXQ1 regulates epithelial-mesenchymal transition in human cancers. Cancer Res. 71, 3076–3086 (2011).",{"doi":2936},"10.1158\u002F0008-5472.CAN-10-2787",{"id":28,"text":2938,"url":28,"identifiers":2939},"Belguise, K., Guo, S. & Sonenshein, G. E. Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor α expression reversing invasive phenotype of breast cancer cells. Cancer Res. 67, 5763–5770 (2007).",{"doi":2940},"10.1158\u002F0008-5472.CAN-06-4327",{"id":28,"text":2942,"url":28,"identifiers":2943},"Song, Y., Washington, M. K. & Crawford, H. C. Loss of FOXA1\u002F2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer. Cancer Res. 70, 2115–2125 (2010).",{"doi":2944},"10.1158\u002F0008-5472.CAN-09-2979",{"id":28,"text":2946,"url":28,"identifiers":2947},"McDonald, O. G., Wu, H., Timp, W., Doi, A. & Feinberg, A. P. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nature Struct. Mol. Biol. 18, 867–874 (2011).",{"doi":2948},"10.1038\u002Fnsmb.2084",{"id":28,"text":2950,"url":28,"identifiers":2951},"Venkov, C. D. et al. A proximal activator of transcription in epithelial-mesenchymal transition. J. Clin. Invest. 117, 482–491 (2007).",{"doi":2952},"10.1172\u002FJCI29544",{"id":28,"text":2954,"url":28,"identifiers":2955},"Slorach, E. M., Chou, J. & Werb, Z. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev. 25, 471–484 (2011).",{"doi":2956},"10.1101\u002Fgad.1998111",{"id":28,"text":2958,"url":28,"identifiers":2959},"Ocana, O. H. et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 22, 709–724 (2012).",{"doi":2960},"10.1016\u002Fj.ccr.2012.10.012",{"id":2962,"createTime":2963,"updateTime":2963,"relativeEntities":2964,"slug":2965,"properties":2966,"entityType":971,"verifyStatus":26,"verifyTime":2963,"verifyNote":972,"languages":2979,"translateLanguages":28,"viewCount":32,"primaryUrl":2980,"fullTextUrl":28,"authors":2981,"publicationType":1063,"publisherRelationship":3039,"citationCount":3093,"citationInfo":3094,"publishDate":3109,"publishYear":3095,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":3110,"openAccess":28,"references":3111,"isForceReanalyzing":1713},"4305fea5-9b4e-405f-a46f-9b779f4d6449","2024-08-30T17:28:18.807+00:00",[],"Membrane-lipids-where-they-are-and-how-they-behave",{"openalex":2967,"mag":2969,"title":2971,"pm":2973,"doi":2975,"pmc":2977},{"VOID":2968},"W2125872855",{"VOID":2970},"2125872855",{"EN":2972},"Membrane lipids: where they are and how they behave",{"VOID":2974},"18216768",{"VOID":2976},"10.1038\u002Fnrm2330",{"VOID":2978},"2642958",[31],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnrm2330",[2982,3001,3020],{"id":2983,"sortIndex":32,"researcher":28,"roles":2984,"affiliations":2985,"properties":2994,"displayName":2998,"givenName":28,"familyName":28},"6b7a1f1e-16a8-4b8e-99ff-1b2dea2d30a7",[],[2986],{"id":2987,"sortIndex":32,"affiliation":2988,"properties":28},"0163e01a-0be1-4ec8-8da6-8a829e1589ec",{"id":2987,"createTime":28,"updateTime":28,"relativeEntities":2989,"slug":28,"properties":2990,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2993,"statistic":28},[],{"title":2991},{"VI":2992},"Bijvoet Center and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands",[],{"orcid":2995,"title":2997,"openalex":2999},{"VOID":2996},"https:\u002F\u002Forcid.org\u002F0000-0002-5976-6436",{"EN":2998},"Gerrit van Meer",{"VOID":3000},"A5030256996",{"id":3002,"sortIndex":40,"researcher":28,"roles":3003,"affiliations":3004,"properties":3013,"displayName":3017,"givenName":28,"familyName":28},"667b83d3-da39-41df-813b-56fafd49c1b1",[],[3005],{"id":3006,"sortIndex":32,"affiliation":3007,"properties":28},"fb12287b-ddb0-4db3-8e33-29036547a92a",{"id":3006,"createTime":28,"updateTime":28,"relativeEntities":3008,"slug":28,"properties":3009,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3012,"statistic":28},[],{"title":3010},{"EN":3011},"Department of Medicine, National Jewish Medical Research Center, Denver, USA",[],{"orcid":3014,"title":3016,"openalex":3018},{"VOID":3015},"https:\u002F\u002Forcid.org\u002F0000-0002-3254-6644",{"EN":3017},"Dennis R. 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LMSD: LIPID MAPS structure database. Nucleic Acids Res. 35, D527–D532 (2007).",{"doi":3115},"10.1093\u002Fnar\u002Fgkl838",{"id":28,"text":3117,"url":28,"identifiers":3118},"Feigenson, G. W. Phase behavior of lipid mixtures. Nature Chem. Biol. 2, 560–563 (2006).",{"doi":3119},"10.1038\u002Fnchembio1106-560",{"id":28,"text":3121,"url":28,"identifiers":3122},"Feigenson, G. W. Phase boundaries and biological membranes. Annu. Rev. Biophys. Biomol. Struct. 36, 63–77 (2007).",{"doi":3123},"10.1146\u002Fannurev.biophys.36.040306.132721",{"id":28,"text":3125,"url":28,"identifiers":3126},"Marsh, M. & Helenius, A. Virus entry: open sesame. Cell 124, 729–740 (2006). Cell biology studies, live-cell imaging and systems biology show that many of the multiple and subtly different pathways that animal viruses use to enter host cells require specific lipids.",{"doi":3127},"10.1016\u002Fj.cell.2006.02.007",{"id":28,"text":3129,"url":28,"identifiers":3130},"van Meer, G. Cellular lipidomics. EMBO J. 24, 3159–3165 (2005).",{"doi":3131},"10.1038\u002Fsj.emboj.7600798",{"id":28,"text":3133,"url":28,"identifiers":3134},"Marsh, D. Lateral pressure profile, spontaneous curvature frustration, and the incorporation and conformation of proteins in membranes. Biophys. J. 93, 3884–3899 (2007).",{"doi":3135},"10.1529\u002Fbiophysj.107.107938",{"id":28,"text":3137,"url":28,"identifiers":3138},"Dowhan, W. & Bogdanov, M. in Biochemistry of Lipids, Lipoproteins and Membranes Vol. 36 (eds Vance, D. E. & Vance, J. E.) 1–35 (Elsevier, Amsterdam, 2002).",{},{"id":28,"text":3140,"url":28,"identifiers":3141},"van Meer, G. & Lisman, Q. Sphingolipid transport: rafts and translocators. J. Biol. Chem. 277, 25855–25858 (2002).",{"doi":3142},"10.1074\u002Fjbc.R200010200",{"id":28,"text":3144,"url":28,"identifiers":3145},"Huang, J. & Feigenson, G. W. A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers. Biophys. J. 76, 2142–2157 (1999). The interactions of cholesterol with membrane lipid lead to abrupt jumps in cholesterol chemical potential because of the hydrophobic interaction, which forces phospholipid headgroups to shield cholesterol from water, as described here by the umbrella model.",{"doi":3146},"10.1016\u002FS0006-3495(99)77369-8",{"id":28,"text":3148,"url":28,"identifiers":3149},"Ali, M. R., Cheng, K. H. & Huang, J. Ceramide drives cholesterol out of the ordered lipid bilayer phase into the crystal phase in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine\u002Fcholesterol\u002Fceramide ternary mixtures. Biochemistry 45, 12629–12638 (2006).",{"doi":3150},"10.1021\u002Fbi060610x",{"id":28,"text":3152,"url":28,"identifiers":3153},"Meyer zu Heringdorf, D. & Jakobs, K. H. Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim. Biophys. Acta 1768, 923–940 (2007).",{"doi":3154},"10.1016\u002Fj.bbamem.2006.09.026",{"id":28,"text":3156,"url":28,"identifiers":3157},"Fernandis, A. Z. & Wenk, M. R. Membrane lipids as signaling molecules. Curr. Opin. Lipidol. 18, 121–128 (2007).",{"doi":3158},"10.1097\u002FMOL.0b013e328082e4d5",{"id":28,"text":3160,"url":28,"identifiers":3161},"Kolesnick, R. & Hannun, Y. A. Ceramide and apoptosis. Trends Biochem. Sci. 24, 224–225 (1999).",{"doi":3162},"10.1016\u002FS0968-0004(99)01408-5",{"id":28,"text":3164,"url":28,"identifiers":3165},"Tepper, A. D. et al. Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology. J. Cell Biol. 150, 155–164 (2000).",{"doi":3166},"10.1083\u002Fjcb.150.1.155",{"id":28,"text":3168,"url":28,"identifiers":3169},"Megha, Sawatzki, P., Kolter, T., Bittman, R. & London, E. Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts). Biochim. Biophys. Acta 1768, 2205–2212 (2007).",{"doi":3170},"10.1016\u002Fj.bbamem.2007.05.007",{"id":28,"text":3172,"url":28,"identifiers":3173},"Bell, R. M., Ballas, L. M. & Coleman, R. A. Lipid topogenesis. J. Lipid Res. 22, 391–403 (1981).",{"doi":3174},"10.1016\u002FS0022-2275(20)34952-X",{"id":28,"text":3176,"url":28,"identifiers":3177},"Sprong, H. et al. UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. J. Biol. Chem. 273, 25880–25888 (1998).",{"doi":3178},"10.1074\u002Fjbc.273.40.25880",{"id":28,"text":3180,"url":28,"identifiers":3181},"Rusinol, A. E., Cui, Z., Chen, M. H. & Vance, J. E. A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J. Biol. Chem. 269, 27494–27502 (1994). Provides evidence for stable physical associations between the ER and mitochondria, and also identifies biochemical properties of this compartment that are distinct from the individual organelles.",{"doi":3182},"10.1016\u002FS0021-9258(18)47012-3",{"id":28,"text":3184,"url":28,"identifiers":3185},"Pichler, H. et al. A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids. Eur. J. Biochem. 268, 2351–2361 (2001).",{"doi":3186},"10.1046\u002Fj.1432-1327.2001.02116.x",{"id":28,"text":3188,"url":28,"identifiers":3189},"Futerman, A. H. & Riezman, H. The ins and outs of sphingolipid synthesis. Trends Cell Biol. 15, 312–318 (2005).",{"doi":3190},"10.1016\u002Fj.tcb.2005.04.006",{"id":28,"text":3192,"url":28,"identifiers":3193},"Henneberry, A. L., Wright, M. M. & McMaster, C. R. The major sites of cellular phospholipid synthesis and molecular determinants of fatty acid and lipid head group specificity. Mol. Biol. Cell 13, 3148–3161 (2002).",{"doi":3194},"10.1091\u002Fmbc.01-11-0540",{"id":28,"text":3196,"url":28,"identifiers":3197},"Voelker, D. R. Bridging gaps in phospholipid transport. Trends Biochem. Sci. 30, 396–404 (2005). Summarizes biochemical and genetic elements of non-vesicular phospholipid transport with highlighted emphasis on PtdSer transport processes in yeast.",{"doi":3198},"10.1016\u002Fj.tibs.2005.05.008",{"id":28,"text":3200,"url":28,"identifiers":3201},"Di Paolo, G. & De Camilli, P. Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651–657 (2006).",{"doi":3202},"10.1038\u002Fnature05185",{"id":28,"text":3204,"url":28,"identifiers":3205},"Geta Tafesse, F. et al. Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells. J. Biol. Chem. 282, 17537–17547 (2007).",{"doi":3206},"10.1074\u002Fjbc.M702423200",{"id":28,"text":3208,"url":28,"identifiers":3209},"Li, Z. et al. Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization. Biochim. Biophys. Acta 1771, 1186–1194 (2007).",{"doi":3210},"10.1016\u002Fj.bbalip.2007.05.007",{"id":28,"text":3212,"url":28,"identifiers":3213},"Kobayashi, T. et al. Separation and characterization of late endosomal membrane domains. J. Biol. Chem. 277, 32157–32164 (2002).",{"doi":3214},"10.1074\u002Fjbc.M202838200",{"id":28,"text":3216,"url":28,"identifiers":3217},"Matsuo, H. et al. Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 303, 531–534 (2004).",{"doi":3218},"10.1126\u002Fscience.1092425",{"id":28,"text":3220,"url":28,"identifiers":3221},"Kolter, T. & Sandhoff, K. Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids. Annu. Rev. Cell Dev. Biol. 21, 81–103 (2005).",{"doi":3222},"10.1146\u002Fannurev.cellbio.21.122303.120013",{"id":28,"text":3224,"url":28,"identifiers":3225},"Vance, D. E. & Vance, J. E. Biochemistry of Lipids, Lipoproteins and Membranes (Elsevier, Amsterdam, 2002).",{},{"id":28,"text":3227,"url":28,"identifiers":3228},"Nagle, C. A. et al. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J. Biol. Chem. 282, 14807–14815 (2007).",{"doi":3229},"10.1074\u002Fjbc.M611550200",{"id":28,"text":3231,"url":28,"identifiers":3232},"Choi, J. Y., Wu, W. I. & Voelker, D. R. Phosphatidylserine decarboxylases as genetic and biochemical tools for studying phospholipid traffic. Anal. Biochem. 347, 165–175 (2005).",{"doi":3233},"10.1016\u002Fj.ab.2005.03.017",{"id":28,"text":3235,"url":28,"identifiers":3236},"Daum, G. Lipids of mitochondria. Biochim. Biophys. Acta 822, 1–42 (1985).",{"doi":3237},"10.1016\u002F0304-4157(85)90002-4",{"id":28,"text":3239,"url":28,"identifiers":3240},"Strauss, J. F., Kishida, T., Christenson, L. K., Fujimoto, T. & Hiroi, H. START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells. Mol. Cell. Endocrinol. 202, 59–65 (2003).",{"doi":3241},"10.1016\u002FS0303-7207(03)00063-7",{"id":28,"text":3243,"url":28,"identifiers":3244},"Devaux, P. F. & Morris, R. Transmembrane asymmetry and lateral domains in biological membranes. Traffic 5, 241–246 (2004).",{"doi":3245},"10.1111\u002Fj.1600-0854.2004.0170.x",{"id":28,"text":3247,"url":28,"identifiers":3248},"Daleke, D. L. Phospholipid flippases. J. Biol. Chem. 282, 821–825 (2007).",{"doi":3249},"10.1074\u002Fjbc.R600035200",{"id":28,"text":3251,"url":28,"identifiers":3252},"Pomorski, T. & Menon, A. K. Lipid flippases and their biological functions. Cell. Mol. Life Sci. 63, 2908–2921 (2006).",{"doi":3253},"10.1007\u002Fs00018-006-6167-7",{"id":28,"text":3255,"url":28,"identifiers":3256},"Anglin, T. C., Liu, J. & Conboy, J. C. Facile lipid flip-flop in a phospholipid bilayer induced by gramicidin A measured by sum-frequency vibrational spectroscopy. Biophys. J. 92, L01–L03 (2007).",{"doi":3257},"10.1529\u002Fbiophysj.106.096057",{"id":28,"text":3259,"url":28,"identifiers":3260},"Papadopulos, A. et al. Flippase activity detected with unlabeled lipids by shape changes of giant unilamellar vesicles. J. Biol. Chem. 282, 15559–15568 (2007).",{"doi":3261},"10.1074\u002Fjbc.M604740200",{"id":28,"text":3263,"url":28,"identifiers":3264},"López-Montero, I. et al. Rapid transbilayer movement of ceramides in phospholipid vesicles and in human erythrocytes. J. Biol. Chem. 280, 25811–25819 (2005).",{"doi":3265},"10.1074\u002Fjbc.M412052200",{"id":28,"text":3267,"url":28,"identifiers":3268},"Ganong, B. R. & Bell, R. M. Transmembrane movement of phosphatidylglycerol and diacylglycerol sulfhydryl analogues. Biochemistry 23, 4977–4983 (1984).",{"doi":3269},"10.1021\u002Fbi00316a023",{"id":28,"text":3271,"url":28,"identifiers":3272},"Bai, J. & Pagano, R. E. Measurement of spontaneous transfer and transbilayer movement of BODIPY-labeled lipids in lipid vesicles. Biochemistry 36, 8840–8848 (1997).",{"doi":3273},"10.1021\u002Fbi970145r",{"id":28,"text":3275,"url":28,"identifiers":3276},"Steck, T. L., Ye, J. & Lange, Y. Probing red cell membrane cholesterol movement with cyclodextrin. Biophys. J. 83, 2118–2125 (2002).",{"doi":3277},"10.1016\u002FS0006-3495(02)73972-6",{"id":28,"text":3279,"url":28,"identifiers":3280},"Cullis, P. R. et al. Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles. Biochim. Biophys. Acta 1331, 187–211 (1997).",{"doi":3281},"10.1016\u002FS0304-4157(97)00006-3",{"id":28,"text":3283,"url":28,"identifiers":3284},"Kol, M. A., de Kroon, A. I., Killian, J. A. & de Kruijff, B. Transbilayer movement of phospholipids in biogenic membranes. Biochemistry 43, 2673–2681 (2004). Summarizes the data and hypotheses that support a generic system for the non-selective transbilayer movement of lipids in the ER of eukaryotes and in the cytoplasmic membranes of bacteria.",{"doi":3285},"10.1021\u002Fbi036200f",{"id":28,"text":3287,"url":28,"identifiers":3288},"Helenius, J. et al. Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415, 447–450 (2002).",{"doi":3289},"10.1038\u002F415447a",{"id":28,"text":3291,"url":28,"identifiers":3292},"Alaimo, C. et al. Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides. EMBO J. 25, 967–976 (2006).",{"doi":3293},"10.1038\u002Fsj.emboj.7601024",{"id":28,"text":3295,"url":28,"identifiers":3296},"Graham, T. R. Flippases and vesicle-mediated protein transport. Trends Cell Biol. 14, 670–677 (2004). Summarizes important relationships between vesicular protein traffic and transbilayer phospholipid transport by P-type ATPases.",{"doi":3297},"10.1016\u002Fj.tcb.2004.10.008",{"id":28,"text":3299,"url":28,"identifiers":3300},"Pomorski, T. et al. Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol. Biol. Cell 14, 1240–1254 (2003). An important paper defining the participation of plasma membrane P-type ATPases in yeast in the transbilayer movement of aminoglycerophospholipids and their interplay with endocytic processes.",{"doi":3301},"10.1091\u002Fmbc.e02-08-0501",{"id":28,"text":3303,"url":28,"identifiers":3304},"Riekhof, W. R. & Voelker, D. R. Uptake and utilization of lyso-phosphatidylethanolamine by Saccharomyces cerevisiae. J. Biol. Chem. 281, 36588–36596 (2006).",{"doi":3305},"10.1074\u002Fjbc.M608851200",{"id":28,"text":3307,"url":28,"identifiers":3308},"Riekhof, W. R. et al. Lyso-phosphatidylcholine metabolism in Saccharomyces cerevisiae. The role of P-type ATPases in transport and a broad specificity acyltransferase in acylation. J. Biol. Chem. 21 Oct 2007 (doi:10.1074\u002Fjbc.M706718200)",{"doi":3309},"10.1074\u002Fjbc.M706718200",{"id":28,"text":3311,"url":28,"identifiers":3312},"Natarajan, P., Wang, J., Hua, Z. & Graham, T. R. Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Proc. Natl. Acad. Sci. USA 101, 10614–10619 (2004).",{"doi":3313},"10.1073\u002Fpnas.0404146101",{"id":28,"text":3315,"url":28,"identifiers":3316},"Alder-Baerens, N., Lisman, Q., Luong, L., Pomorski, T. & Holthuis, J. C. Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Mol. Biol. Cell 17, 1632–1642 (2006).",{"doi":3317},"10.1091\u002Fmbc.e05-10-0912",{"id":28,"text":3319,"url":28,"identifiers":3320},"Wang, X. et al. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nature Cell Biol. 9, 541–549 (2007).",{"doi":3321},"10.1038\u002Fncb1574",{"id":28,"text":3323,"url":28,"identifiers":3324},"Züllig, S. et al. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Curr. Biol. 17, 994–999 (2007).",{"doi":3325},"10.1016\u002Fj.cub.2007.05.024",{"id":28,"text":3327,"url":28,"identifiers":3328},"van Meer, G. & Simons, K. The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells. EMBO J. 5, 1455–1464 (1986).",{"doi":3329},"10.1002\u002Fj.1460-2075.1986.tb04382.x",{"id":28,"text":3331,"url":28,"identifiers":3332},"Young, W. W. Jr, Lutz, M. S. & Blackburn, W. A. Endogenous glycosphingolipids move to the cell surface at a rate consistent with bulk flow estimates. J. Biol. Chem. 267, 12011–12015 (1992).",{"doi":3333},"10.1016\u002FS0021-9258(19)49798-6",{"id":28,"text":3335,"url":28,"identifiers":3336},"Baumann, N. A. et al. Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration. Biochemistry 44, 5816–5826 (2005).",{"doi":3337},"10.1021\u002Fbi048296z",{"id":28,"text":3339,"url":28,"identifiers":3340},"Simons, K. & van Meer, G. Lipid sorting in epithelial cells. Biochemistry 27, 6197–6202 (1988).",{"doi":3341},"10.1021\u002Fbi00417a001",{"id":28,"text":3343,"url":28,"identifiers":3344},"Halter, D. et al. Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis J. Cell Biol. 179, 101–115 (2007). Suggests that the late Golgi protein FAPP2 transports GlcCer that is destined for complex glycolipid synthesis back to the ER, whereas GlcCer translocation to the cell surface depends on a proton gradient.",{"doi":3345},"10.1083\u002Fjcb.200704091",{"id":28,"text":3347,"url":28,"identifiers":3348},"Smith, D. C. et al. The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect. Mol. Biol. Cell 17, 1375–1387 (2006).",{"doi":3349},"10.1091\u002Fmbc.e05-11-1035",{"id":28,"text":3351,"url":28,"identifiers":3352},"Sharma, D. K. et al. Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for recycling. J. Biol. Chem. 278, 7564–7572 (2003). Demonstrates the non-uniform distribution of fluorescent phospholipids within individual endosomes.",{"doi":3353},"10.1074\u002Fjbc.M210457200",{"id":28,"text":3355,"url":28,"identifiers":3356},"Wang, T. Y. & Silvius, J. R. Different sphingolipids show differential partitioning into sphingolipid\u002Fcholesterol-rich domains in lipid bilayers. Biophys. J. 79, 1478–1489 (2000).",{"doi":3357},"10.1016\u002FS0006-3495(00)76399-5",{"id":28,"text":3359,"url":28,"identifiers":3360},"Singh, R. D. et al. Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer. J. Cell Biol. 176, 895–901 (2007).",{"doi":3361},"10.1083\u002Fjcb.200609149",{"id":28,"text":3363,"url":28,"identifiers":3364},"Sleight, R. G. & Pagano, R. E. Rapid appearance of newly synthesized phosphatidylethanolamine at the plasma membrane. J. Biol. Chem. 258, 9050–9058 (1983).",{"doi":3365},"10.1016\u002FS0021-9258(17)44630-8",{"id":28,"text":3367,"url":28,"identifiers":3368},"Kaplan, M. R. & Simoni, R. D. Intracellular transport of phosphatidylcholine to the plasma membrane. J. Cell Biol. 101, 441–445 (1985).",{"doi":3369},"10.1083\u002Fjcb.101.2.441",{"id":28,"text":3371,"url":28,"identifiers":3372},"Voelker, D. R. Characterization of phosphatidylserine synthesis and translocation in permeabilized animal cells. J. Biol. Chem. 265, 14340–14346 (1990).",{"doi":3373},"10.1016\u002FS0021-9258(18)77306-7",{"id":28,"text":3375,"url":28,"identifiers":3376},"Vance, J. E., Aasman, E. J. & Szarka, R. Brefeldin A does not inhibit the movement of phosphatidylethanolamine from its sites of synthesis to the cell surface. J. Biol. Chem. 266, 8241–8247 (1991).",{"doi":3377},"10.1016\u002FS0021-9258(18)92968-6",{"id":28,"text":3379,"url":28,"identifiers":3380},"Wu, W. I. & Voelker, D. R. Characterization of phosphatidylserine transport to the locus of phosphatidylserine decarboxylase 2 in permeabilized yeast. J. Biol. Chem. 276, 7114–7121 (2001).",{"doi":3381},"10.1074\u002Fjbc.M010278200",{"id":28,"text":3383,"url":28,"identifiers":3384},"Schumacher, M. M., Choi, J. Y. & Voelker, D. R. Phosphatidylserine transport to the mitochondria is regulated by ubiquitination. J. Biol. Chem. 277, 51033–51042 (2002).",{"doi":3385},"10.1074\u002Fjbc.M205301200",{"id":28,"text":3387,"url":28,"identifiers":3388},"Papadopoulos, V. et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol. Sci. 27, 402–409 (2006). Summarizes the major protein constituents involved in non-vesicular import of cholesterol into the mitochondria of cells involved in steroid hormone synthesis.",{"doi":3389},"10.1016\u002Fj.tips.2006.06.005",{"id":28,"text":3391,"url":28,"identifiers":3392},"Hanada, K. et al. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426, 803–809 (2003). An important paper defining the genetic and biochemical mechanisms for non-vesicular transport of ceramide between the ER and the Golgi apparatus.",{"doi":3393},"10.1038\u002Fnature02188",{"id":28,"text":3395,"url":28,"identifiers":3396},"Warnock, D. E., Lutz, M. S., Blackburn, W. A., Young, W. W. Jr & Baenziger, J. U. Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway. Proc. Natl. Acad. Sci. USA 91, 2708–2712 (1994).",{"doi":3397},"10.1073\u002Fpnas.91.7.2708",{"id":28,"text":3399,"url":28,"identifiers":3400},"Trotter, P. J., Wu, W. I., Pedretti, J., Yates, R. & Voelker, D. R. A genetic screen for aminophospholipid transport mutants identifies the phosphatidylinositol 4-kinase, STT4p, as an essential component in phosphatidylserine metabolism. J. Biol. Chem. 273, 13189–13196 (1998).",{"doi":3401},"10.1074\u002Fjbc.273.21.13189",{"id":28,"text":3403,"url":28,"identifiers":3404},"Wu, W. I. & Voelker, D. R. Reconstitution of phosphatidylserine transport from chemically defined donor membranes to phosphatidylserine decarboxylase 2 implicates specific lipid domains in the process. J. Biol. Chem. 279, 6635–6642 (2004).",{"doi":3405},"10.1074\u002Fjbc.M311570200",{"id":28,"text":3407,"url":28,"identifiers":3408},"Raychaudhuri, S., Im, Y. J., Hurley, J. H. & Prinz, W. A. Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J. Cell Biol. 173, 107–119 (2006).",{"doi":3409},"10.1083\u002Fjcb.200510084",{"id":28,"text":3411,"url":28,"identifiers":3412},"D'Angelo, G. et al. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature 449, 62–67 (2007). Shows that FAPP2, a protein that is associated with the generation of transport carriers from the Golgi to the plasma membrane, appears to be a GlcCer transfer protein with a pivotal role in complex GSL synthesis.",{"doi":3413},"10.1038\u002Fnature06097",{"id":28,"text":3415,"url":28,"identifiers":3416},"Awai, K., Xu, C., Tamot, B. & Benning, C. A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking. Proc. Natl Acad. Sci. USA 103, 10817–10822 (2006). Defines transport and intermembrane recognition components for moving phospholipids between the outer and inner chloroplast membranes.",{"doi":3417},"10.1073\u002Fpnas.0602754103",{"id":28,"text":3419,"url":28,"identifiers":3420},"Tefsen, B., Geurtsen, J., Beckers, F., Tommassen, J. & de Cock, H. Lipopolysaccharide transport to the bacterial outer membrane in spheroplasts. J. Biol. Chem. 280, 4504–4509 (2005).",{"doi":3421},"10.1074\u002Fjbc.M409259200",{"id":28,"text":3423,"url":28,"identifiers":3424},"Mousley, C. J., Tyeryar, K. R., Vincent-Pope, P. & Bankaitis, V. A. The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking. Biochim. Biophys. Acta 1771, 727–736 (2007).",{"doi":3425},"10.1016\u002Fj.bbalip.2007.04.002",{"id":28,"text":3427,"url":28,"identifiers":3428},"Litvak, V., Dahan, N., Ramachandran, S., Sabanay, H. & Lev, S. Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nature Cell Biol. 7, 225–234 (2005).",{"doi":3429},"10.1038\u002Fncb1221",{"id":28,"text":3431,"url":28,"identifiers":3432},"Chernomordik, L., Kozlov, M. M. & Zimmerberg, J. Lipids in biological membrane fusion. J. Membr. Biol. 146, 1–14 (1995).",{"doi":3433},"10.1007\u002FBF00232676",{"id":28,"text":3435,"url":28,"identifiers":3436},"Shemesh, T., Luini, A., Malhotra, V., Burger, K. N. & Kozlov, M. M. Prefission constriction of Golgi tubular carriers driven by local lipid metabolism: a theoretical model. Biophys. J. 85, 3813–3827 (2003).",{"doi":3437},"10.1016\u002FS0006-3495(03)74796-1",{"id":28,"text":3439,"url":28,"identifiers":3440},"Gennis, R. B. Biomembranes. Molecular Structure and Function (Springer Verlag, New York, 1989).",{"doi":3441},"10.1007\u002F978-1-4757-2065-5",{"id":28,"text":3443,"url":28,"identifiers":3444},"Takamori, S. et al. Molecular anatomy of a trafficking organelle. Cell 127, 831–846 (2006). A careful reconstruction of synaptic vesicles shows that cholesterol and phospholipids (molar ratio 0.8) cover ∼70% of the surface while transmembrane helices cover 20%, with a lipid\u002Fprotein ratio of 0.75 (w\u002Fw).",{"doi":3445},"10.1016\u002Fj.cell.2006.10.030",{"id":28,"text":3447,"url":28,"identifiers":3448},"Dietrich, C., Volovyk, Z. N., Levi, M., Thompson, N. L. & Jacobson, K. Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers. Proc. Natl Acad. Sci. USA 98, 10642–10647 (2001).",{"doi":3449},"10.1073\u002Fpnas.191168698",{"id":28,"text":3451,"url":28,"identifiers":3452},"Morse, S. A. Basalts and Phase Diagrams (Springer-Verlag, New York, 1980).",{"doi":3453},"10.1007\u002F978-1-4612-6081-3",{"id":28,"text":3455,"url":28,"identifiers":3456},"Parton, R. G. Ultrastructural localization of gangliosides: GM1 is concentrated in caveolae. J. Histochem. Cytochem. 42, 155–166 (1994).",{"doi":3457},"10.1177\u002F42.2.8288861",{"id":28,"text":3459,"url":28,"identifiers":3460},"Kusumi, A. et al. Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu. Rev. Biophys. Biomol. Struct. 34, 351–378 (2005). Biological membrane lipids and proteins are divided into regions, some tens of nanometres in size, which have distinct molecular components and properties.",{"doi":3461},"10.1146\u002Fannurev.biophys.34.040204.144637",{"id":28,"text":3463,"url":28,"identifiers":3464},"Lagerholm, B. C., Weinreb, G. E., Jacobson, K. & Thompson, N. L. Detecting microdomains in intact cell membranes. Annu. Rev. Phys. Chem. 56, 309–336 (2005).",{"doi":3465},"10.1146\u002Fannurev.physchem.56.092503.141211",{"id":28,"text":3467,"url":28,"identifiers":3468},"Feigenson, G. W. & Buboltz, J. T. Ternary phase diagram of dipalmitoyl-PC\u002Fdilauroyl-PC\u002Fcholesterol: nanoscopic domain formation driven by cholesterol. Biophys. J. 80, 2775–2788 (2001).",{"doi":3469},"10.1016\u002FS0006-3495(01)76245-5",{"id":28,"text":3471,"url":28,"identifiers":3472},"Meder, D., Moreno, M. J., Verkade, P., Vaz, W. L. & Simons, K. Phase coexistence and connectivity in the apical membrane of polarized epithelial cells. Proc. Natl Acad. Sci. USA 103, 329–334 (2006).",{"doi":3473},"10.1073\u002Fpnas.0509885103",{"id":28,"text":3475,"url":28,"identifiers":3476},"Kusumi, A., Koyama-Honda, I. & Suzuki, K. Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts. Traffic 5, 213–230 (2004).",{"doi":3477},"10.1111\u002Fj.1600-0854.2004.0178.x",{"id":28,"text":3479,"url":28,"identifiers":3480},"Bollinger, C. R., Teichgraber, V. & Gulbins, E. Ceramide-enriched membrane domains. Biochim. Biophys. Acta 1746, 284–294 (2005).",{"doi":3481},"10.1016\u002Fj.bbamcr.2005.09.001",{"id":28,"text":3483,"url":28,"identifiers":3484},"Roux, A. et al. Role of curvature and phase transition in lipid sorting and fission of membrane tubules. EMBO J. 24, 1537–1545 (2005).",{"doi":3485},"10.1038\u002Fsj.emboj.7600631",{"id":28,"text":3487,"url":28,"identifiers":3488},"Chiantia, S., Kahya, N., Ries, J. & Schwille, P. Effects of ceramide on liquid-ordered domains investigated by simultaneous AFM and FCS. Biophys. J. 90, 4500–4508 (2006).",{"doi":3489},"10.1529\u002Fbiophysj.106.081026",{"id":28,"text":3491,"url":28,"identifiers":3492},"Sot, J., Bagatolli, L. A., Goni, F. M. & Alonso, A. Detergent-resistant, ceramide-enriched domains in sphingomyelin\u002Fceramide bilayers. Biophys. J. 90, 903–914 (2006).",{"doi":3493},"10.1529\u002Fbiophysj.105.067710",{"id":28,"text":3495,"url":28,"identifiers":3496},"Anishkin, A., Sukharev, S. & Colombini, M. Searching for the molecular arrangement of transmembrane ceramide channels. Biophys. J. 90, 2414–2426 (2006).",{"doi":3497},"10.1529\u002Fbiophysj.105.071977",{"id":28,"text":3499,"url":28,"identifiers":3500},"Dietrich, C., Yang, B., Fujiwara, T., Kusumi, A. & Jacobson, K. Relationship of lipid rafts to transient confinement zones detected by single particle tracking. Biophys. J. 82, 274–284 (2002).",{"doi":3501},"10.1016\u002FS0006-3495(02)75393-9",{"id":28,"text":3503,"url":28,"identifiers":3504},"Sengupta, P., Baird, B. & Holowka, D. Lipid rafts, fluid\u002Ffluid phase separation, and their relevance to plasma membrane structure and function. Semin. Cell Dev. Biol. 18, 583–590 (2007).",{"doi":3505},"10.1016\u002Fj.semcdb.2007.07.010",{"id":28,"text":3507,"url":28,"identifiers":3508},"Dibble, A. R. & Feigenson, G. W. Detection of coexisting fluid phospholipid phases by equilibrium Ca2+ binding: peptide-poor Lα and peptide-rich HII phase coexistence in gramicidin A′\u002Fphospholipid dispersions. Biochemistry 33, 12945–12953 (1994).",{"doi":3509},"10.1021\u002Fbi00248a002",{"id":28,"text":3511,"url":28,"identifiers":3512},"Lewis, R. N. et al. Studies of the minimum hydrophobicity of α-helical peptides required to maintain a stable transmembrane association with phospholipid bilayer membranes. Biochemistry 46, 1042–1054 (2007).",{"doi":3513},"10.1021\u002Fbi061891b",{"id":28,"text":3515,"url":28,"identifiers":3516},"Jacobson, K., Mouritsen, O. G. & Anderson, R. G. Lipid rafts: at a crossroad between cell biology and physics. Nature Cell Biol. 9, 7–14 (2007). Proposes a model whereby transmembrane helices cover 15% of the surface and physically contact 30% of the membrane lipids, termed shell lipids. On receiving a signal, proteins control phase behaviour by combining their shell with similar lipid shells of other proteins.",{"doi":3517},"10.1038\u002Fncb0107-7",{"id":28,"text":3519,"url":28,"identifiers":3520},"Shogomori, H. et al. Palmitoylation and intracellular domain interactions both contribute to raft targeting of linker for activation of T cells. J. Biol. Chem. 280, 18931–18942 (2005).",{"doi":3521},"10.1074\u002Fjbc.M500247200",{"id":28,"text":3523,"url":28,"identifiers":3524},"Brown, D. A. Lipid rafts, detergent-resistant membranes, and raft targeting signals. Physiology 21, 430–439 (2006). The use of detergent resistance to study the properties of biological membranes gives indirect information about protein and lipid phase preferences, but does not capture a snapshot of actual phase behaviour.",{"doi":3525},"10.1152\u002Fphysiol.00032.2006",{"id":28,"text":3527,"url":28,"identifiers":3528},"Epand, R. M. Cholesterol and the interaction of proteins with membrane domains. Prog. Lipid Res. 45, 279–294 (2006).",{"doi":3529},"10.1016\u002Fj.plipres.2006.02.001",{"id":28,"text":3531,"url":28,"identifiers":3532},"Hancock, J. F. Lipid rafts: contentious only from simplistic standpoints. Nature Rev. Mol. Cell Biol. 7, 456–462 (2006). A critical discussion of lipid rafts, stressing that protein–protein interactions make major contributions to the stability of lipid-based domains, and that proteins and specific lipids such as cholesterol may accumulate at and affect domain boundaries.",{"doi":3533},"10.1038\u002Fnrm1925",{"id":28,"text":3535,"url":28,"identifiers":3536},"London, E. & Feigenson, G. W. Fluorescence quenching in model membranes. 2. Determination of local lipid environment of the calcium adenosinetriphosphatase from sarcoplasmic reticulum. Biochemistry 20, 1939–1948 (1981).",{"doi":3537},"10.1021\u002Fbi00510a033",{"id":28,"text":3539,"url":28,"identifiers":3540},"Caffrey, M. & Feigenson, G. W. Fluorescence quenching in model membranes. 3. Relationship between calcium adenosinetriphosphatase enzyme activity and the affinity of the protein for phosphatidylcholines with different acyl chain characteristics. Biochemistry 20, 1949–1961 (1981).",{"doi":3541},"10.1021\u002Fbi00510a034",{"id":28,"text":3543,"url":28,"identifiers":3544},"Esmann, M. & Marsh, D. Lipid–protein interactions with the Na, K-ATPase. Chem. Phys. Lipids 141, 94–104 (2006).",{"doi":3545},"10.1016\u002Fj.chemphyslip.2006.02.018",{"id":28,"text":3547,"url":28,"identifiers":3548},"Soubias, O., Teague, W. E. & Gawrisch, K. Evidence for specificity in lipid–rhodopsin interactions. J. Biol. Chem. 281, 33233–33241 (2006).",{"doi":3549},"10.1074\u002Fjbc.M603059200",{"id":28,"text":3551,"url":28,"identifiers":3552},"Andersen, O. S. & Koeppe, R. E. 2nd. Bilayer thickness and membrane protein function: an energetic perspective. Annu. Rev. Biophys. Biomol. Struct. 36, 107–130 (2007).",{"doi":3553},"10.1146\u002Fannurev.biophys.36.040306.132643",{"id":28,"text":3555,"url":28,"identifiers":3556},"Sharma, P. et al. Nanoscale organization of multiple GPI-anchored proteins in living cell membranes. Cell 116, 577–589 (2004).",{"doi":3557},"10.1016\u002FS0092-8674(04)00167-9",{"id":28,"text":3559,"url":28,"identifiers":3560},"Recktenwald, D. J. & McConnell, H. M. Phase equilibria in binary mixtures of phosphatidylcholine and cholesterol. Biochemistry 20, 4505–4510 (1981).",{"doi":3561},"10.1021\u002Fbi00518a042",{"id":28,"text":3563,"url":28,"identifiers":3564},"Wang, T. Y. & Silvius, J. R. Cholesterol does not induce segregation of liquid-ordered domains in bilayers modeling the inner leaflet of the plasma membrane. Biophys. J. 81, 2762–2773 (2001).",{"doi":3565},"10.1016\u002FS0006-3495(01)75919-X",{"id":28,"text":3567,"url":28,"identifiers":3568},"Kiessling, V., Crane, J. M. & Tamm, L. K. Transbilayer effects of raft-like lipid domains in asymmetric planar bilayers measured by single molecule tracking. Biophys. J. 91, 3313–3326 (2006).",{"doi":3569},"10.1529\u002Fbiophysj.106.091421",{"id":28,"text":3571,"url":28,"identifiers":3572},"van Meer, G., Halter, D., Sprong, H., Somerharju, P. & Egmond, M. R. ABC lipid transporters: extruders, flippases, or flopless activators? FEBS Lett. 580, 1171–1177 (2006).",{"doi":3573},"10.1016\u002Fj.febslet.2005.12.019",{"id":28,"text":3575,"url":28,"identifiers":3576},"Veatch, S. L. & Keller, S. L. Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. Biophys. J. 85, 3074–3083 (2003).",{"doi":3577},"10.1016\u002FS0006-3495(03)74726-2",{"id":28,"text":3579,"url":28,"identifiers":3580},"Veatch, S. L., Polozov, I. V., Gawrisch, K. & Keller, S. L. Liquid domains in vesicles investigated by NMR and fluorescence microscopy. Biophys. J. 86, 2910–2922 (2004).",{"doi":3581},"10.1016\u002FS0006-3495(04)74342-8",{"id":28,"text":3583,"url":28,"identifiers":3584},"Wassall, S. R. et al. Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation. Chem. Phys. Lipids 132, 79–88 (2004).",{},{"id":28,"text":3586,"url":28,"identifiers":3587},"Veatch, S. L., Gawrisch, K. & Keller, S. L. Closed-loop miscibility gap and quantitative tie-lines in ternary membranes containing diphytanoyl PC. Biophys. J. 90, 4428–4436 (2006).",{"doi":3588},"10.1529\u002Fbiophysj.105.080283",{"id":28,"text":3590,"url":28,"identifiers":3591},"Bakht, O., Pathak, P. & London, E. Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): identification of multiple raft-stabilization mechanisms. Biophys. J. 93, 4307–4318 (2007). Polyunsaturated acyl chains of membrane lipids can effectively drive the formation of membrane rafts because of especially poor packing with cholesterol.",{"doi":3592},"10.1529\u002Fbiophysj.107.114967",{"id":28,"text":3594,"url":28,"identifiers":3595},"Kucerka, N., Tristram-Nagle, S. & Nagle, J. F. Closer look at structure of fully hydrated fluid phase DPPC bilayers. Biophys. J. 90, L83–L85 (2006).",{"doi":3596},"10.1529\u002Fbiophysj.106.086017",{"id":28,"text":3598,"url":28,"identifiers":3599},"Liu, K., Hua, Z., Nepute, J. A. & Graham, T. R. Yeast P4-ATPases Drs2p and Dnf1p are essential cargos of the NPFXD\u002FSla1p endocytic pathway. Mol. Biol. Cell 18, 487–500 (2007).",{"doi":3600},"10.1091\u002Fmbc.e06-07-0592",{"id":3602,"createTime":3603,"updateTime":3603,"relativeEntities":3604,"slug":3605,"properties":3606,"entityType":971,"verifyStatus":26,"verifyTime":3603,"verifyNote":972,"languages":3617,"translateLanguages":28,"viewCount":32,"primaryUrl":3618,"fullTextUrl":28,"authors":3619,"publicationType":1063,"publisherRelationship":3658,"citationCount":3712,"citationInfo":3713,"publishDate":3724,"publishYear":3714,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":3725,"openAccess":28,"references":3726,"isForceReanalyzing":1713},"8b6ef4ab-26ca-4fcf-882d-e61863dbeb7f","2024-09-18T18:47:03.702+00:00",[],"Lipid-rafts-and-signal-transduction",{"openalex":3607,"mag":3609,"title":3611,"pm":3613,"doi":3615},{"VOID":3608},"W1564861448",{"VOID":3610},"1564861448",{"EN":3612},"Lipid rafts and signal 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D. A. & London, E. Functions of lipid rafts in biological membranes. Annu. Rev. Cell. Dev. Biol. 14, 111–136 (1998).",{"doi":3730},"10.1146\u002Fannurev.cellbio.14.1.111",{"id":28,"text":3732,"url":28,"identifiers":3733},"Sankaram, M. B. & Thompson, T. E. Interaction of cholesterol with various glycerophospholipids and sphingomyelin. Biochemistry 29, 10670–10675 (1990).",{"doi":3734},"10.1021\u002Fbi00499a014",{"id":28,"text":3736,"url":28,"identifiers":3737},"Simons, K. & van Meer, G. Lipid sorting in epithelial cells . Biochemistry 27, 6197– 6202 (1988).",{"doi":3341},{"id":28,"text":3739,"url":28,"identifiers":3740},"Simons, K. & Ikonen, E. Functional rafts in cell membranes . Nature 387, 569–572 (1997).",{"doi":3741},"10.1038\u002F42408",{"id":28,"text":3743,"url":28,"identifiers":3744},"Fridriksson, E. K. et al. Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry. Biochemistry 38, 8056– 8063 (1999).",{"doi":3745},"10.1021\u002Fbi9828324",{"id":28,"text":3747,"url":28,"identifiers":3748},"Schroeder, R., London, E. & Brown, D. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior. Proc. Natl Acad. Sci. USA 91, 12130– 12134 (1994).",{"doi":3749},"10.1073\u002Fpnas.91.25.12130",{"id":28,"text":3751,"url":28,"identifiers":3752},"Hooper, N. M. Detergent-insoluble glycosphingolipid\u002Fcholesterol-rich membrane domains, lipid rafts and caveolae. Mol. Membr. Biol. 16, 145–156 (1999).",{"doi":3753},"10.1080\u002F096876899294607",{"id":28,"text":3755,"url":28,"identifiers":3756},"Resh, M. D. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim. Biophys. Acta 1451, 1–16 (1999).",{"doi":3757},"10.1016\u002FS0167-4889(99)00075-0",{"id":28,"text":3759,"url":28,"identifiers":3760},"Rietveld, A., Neutz, S., Simons, K. & Eaton, S. Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. J. Biol. Chem. 274, 12049–12054 (1999).",{"doi":3761},"10.1074\u002Fjbc.274.17.12049",{"id":28,"text":3763,"url":28,"identifiers":3764},"Scheiffele, P., Roth, M. G. & Simons, K. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J. 16, 5501–5508 (1997).",{"doi":3765},"10.1093\u002Femboj\u002F16.18.5501",{"id":28,"text":3767,"url":28,"identifiers":3768},"Melkonian, K. A., Ostermeyer, A. G., Chen, J. Z., Roth, M. G. & Brown, D. A. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated. J. Biol. Chem. 274, 3910–3917 (1999).",{"doi":3769},"10.1074\u002Fjbc.274.6.3910",{"id":28,"text":3771,"url":28,"identifiers":3772},"Harder, T., Scheiffele, P., Verkade, P. & Simons, K. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141, 929– 942 (1998).The first demonstration that clusters of rafts segregate away from non-raft proteins.",{"doi":3773},"10.1083\u002Fjcb.141.4.929",{"id":28,"text":3775,"url":28,"identifiers":3776},"Palade, G. E. The fine structure of blood capillaries. J. Appl. Phys. 24, 1424 (1953).",{},{"id":28,"text":3778,"url":28,"identifiers":3779},"Yamada, E. The fine structure of the gall bladder epithelium of the mouse. J. Biophys. Biochem. Cytol. 1, 445– 458 (1955).",{"doi":3780},"10.1083\u002Fjcb.1.5.445",{"id":28,"text":3782,"url":28,"identifiers":3783},"Parton, R. G. Caveolae and caveolins. Curr. Opin. Cell Biol. 8, 542–548 (1996).",{"doi":3784},"10.1016\u002FS0955-0674(96)80033-0",{"id":28,"text":3786,"url":28,"identifiers":3787},"Smart, E. J. et al. Caveolins, liquid-ordered domains, and signal transduction . Mol. Cell. Biol. 19, 7289– 7304 (1999).",{"doi":3788},"10.1128\u002FMCB.19.11.7289",{"id":28,"text":3790,"url":28,"identifiers":3791},"Schnitzer, J. E., Oh, P., Pinney, E. & Allard, J. Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J. Cell Biol. 127, 1217–1232 (1994).",{"doi":3792},"10.1083\u002Fjcb.127.5.1217",{"id":28,"text":3794,"url":28,"identifiers":3795},"Parton, R. G., Way, M., Zorzi, N. & Stang, E. Caveolin-3 associates with developing T-tubules during muscle differentiation. J. Cell Biol. 136, 137–154 ( 1997).",{"doi":3796},"10.1083\u002Fjcb.136.1.137",{"id":28,"text":3798,"url":28,"identifiers":3799},"Anderson, R. G. The caveolae membrane system. Annu. Rev. Biochem. 67 , 199–225 (1998).",{"doi":3800},"10.1146\u002Fannurev.biochem.67.1.199",{"id":28,"text":3802,"url":28,"identifiers":3803},"Vogel, U., Sandvig, K. & van Deurs, B. Expression of caveolin-1 and polarized formation of invaginated caveolae in Caco-2 and MDCK II cells. J. Cell Sci. 111, 825–832 ( 1998).",{"doi":3804},"10.1242\u002Fjcs.111.6.825",{"id":28,"text":3806,"url":28,"identifiers":3807},"Renkonen, O., Kaarainen, L., Simons, K. & Gahmberg, C. G. The lipid class composition of Semliki forest virus and plasma membranes of the host cells. Virology 46, 318– 326 (1971).",{"doi":3808},"10.1016\u002F0042-6822(71)90033-X",{"id":28,"text":3810,"url":28,"identifiers":3811},"Levis, G. M. & Evangelatos, G. P. Lipid composition of lymphocyte plasma membrane from pig mesenteric lymph node. Biochem. J. 156, 103–110 (1976).",{"doi":3812},"10.1042\u002Fbj1560103",{"id":28,"text":3814,"url":28,"identifiers":3815},"van Meer, G. Lipid traffic in animal cells. Annu. Rev. Cell Biol. 5, 247–275 (1989).",{"doi":3816},"10.1146\u002Fannurev.cb.05.110189.001335",{"id":28,"text":3818,"url":28,"identifiers":3819},"Brugger, B. et al. Segregation from COPI–coated vesicles of sphingomyelin and cholesterol. J. Cell Biol. (in the press).",{},{"id":28,"text":3821,"url":28,"identifiers":3822},"Keller, P. & Simons, K. Post-Golgi biosynthetic trafficking . J. Cell Sci. 110, 3001– 3009 (1997).",{"doi":3823},"10.1242\u002Fjcs.110.24.3001",{"id":28,"text":3825,"url":28,"identifiers":3826},"Ledesma, M. D., Simons, K. & Dotti, C. G. Neuronal polarity: essential role of protein–lipid complexes in axonal sorting. Proc. Natl Acad. Sci. USA 95, 3966–3971 (1998).",{"doi":3827},"10.1073\u002Fpnas.95.7.3966",{"id":28,"text":3829,"url":28,"identifiers":3830},"Mukherjee, S. & Maxfield, F. Role of membrane organization and membrane domains in endocytic lipid trafficking. Traffic 1, 203–211 (2000).",{"doi":3831},"10.1034\u002Fj.1600-0854.2000.010302.x",{"id":28,"text":3833,"url":28,"identifiers":3834},"Puri, V. et al. Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases. Nature Cell Biol. 1, 386–388 (1999).",{"doi":3835},"10.1038\u002F14084",{"id":28,"text":3837,"url":28,"identifiers":3838},"Janes, P. W., Ley, S. C. & Magee, A. I. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147, 447–461 (1999).",{"doi":3839},"10.1083\u002Fjcb.147.2.447",{"id":28,"text":3841,"url":28,"identifiers":3842},"Pralle, A., Keller, P., Florin, E. L., Simons, K. & Horber, J. K. Sphingolipid–cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells . J. Cell Biol. 148, 997– 1008 (2000).Individual raft size is measured by photonic force microscopy.",{"doi":3843},"10.1083\u002Fjcb.148.5.997",{"id":28,"text":3845,"url":28,"identifiers":3846},"Varma, R. & Mayor, S. GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394 , 798–801 (1998).",{"doi":3847},"10.1038\u002F29563",{"id":28,"text":3849,"url":28,"identifiers":3850},"Friedrichson, T. & Kurzchalia, T. V. Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature 394, 802–805 ( 1998).",{"doi":3851},"10.1038\u002F29570",{"id":28,"text":3853,"url":28,"identifiers":3854},"Kenworthy, A. K., Petranova, N. & Edidin, M. High-resolution FRET microscopy of cholera toxin B-subunit and GPI-anchored proteins in cell plasma membranes. Mol. Biol. Cell 11, 1645–1655 ( 2000).",{"doi":3855},"10.1091\u002Fmbc.11.5.1645",{"id":28,"text":3857,"url":28,"identifiers":3858},"Brown, D. A. & Rose, J. K. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68, 533– 544 (1992).A pioneering demonstration that GPI-anchored proteins and influenza haemagglutinin remain associated with sphingolipids and cholesterol after Triton X-100 extraction.",{"doi":3859},"10.1016\u002F0092-8674(92)90189-J",{"id":28,"text":3861,"url":28,"identifiers":3862},"Waugh, M. G., Lawson, D. & Hsuan, J. J. Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains. Biochem. J. 337, 591–597 ( 1999).",{"doi":3863},"10.1042\u002Fbj3370591",{"id":28,"text":3865,"url":28,"identifiers":3866},"Webb, Y., Hermida-Matsumoto, L. & Resh, M. D. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J. Biol. Chem. 275, 261–270 (2000).Feeding cells with polyunsaturated fatty acids leads to dissociation of doubly acylated proteins from rafts.",{"doi":3867},"10.1074\u002Fjbc.275.1.261",{"id":28,"text":3869,"url":28,"identifiers":3870},"Simons, M. et al. Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells. Mol. Biol. Cell 10, 3187–3196 ( 1999).",{"doi":3871},"10.1091\u002Fmbc.10.10.3187",{"id":28,"text":3873,"url":28,"identifiers":3874},"Hunter, T. Signaling — 2000 and beyond. Cell 100, 113–127 (2000).",{"doi":3875},"10.1016\u002FS0092-8674(00)81688-8",{"id":28,"text":3877,"url":28,"identifiers":3878},"Field, K. A., Holowka, D. & Baird, B. Fc epsilon RI-mediated recruitment of p53\u002F56lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc. Natl Acad. Sci. USA 92, 9201–9205 ( 1995).",{"doi":3879},"10.1073\u002Fpnas.92.20.9201",{"id":28,"text":3881,"url":28,"identifiers":3882},"Sheets, E. D., Holowka, D. & Baird, B. Membrane organization in immunoglobulin E receptor signaling . Curr. Opin. Chem. Biol. 3, 95– 99 (1999).",{"doi":3883},"10.1016\u002FS1367-5931(99)80017-9",{"id":28,"text":3885,"url":28,"identifiers":3886},"Baird, B., Sheets, E. D. & Holowka, D. How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E? Biophys. Chem. 82, 109–119 (1999).",{"doi":3887},"10.1016\u002FS0301-4622(99)00110-6",{"id":28,"text":3889,"url":28,"identifiers":3890},"Metzger, H. It's spring, and thoughts turn to… allergies. Cell 97, 287–290 (1999).",{"doi":3891},"10.1016\u002FS0092-8674(00)80738-2",{"id":28,"text":3893,"url":28,"identifiers":3894},"Stauffer, T. P. & Meyer, T. Compartmentalized IgE receptor-mediated signal transduction in living cells. J. Cell Biol. 139, 1447–1454 ( 1997).",{"doi":3895},"10.1083\u002Fjcb.139.6.1447",{"id":28,"text":3897,"url":28,"identifiers":3898},"Holowka, D., Sheets, E. D. & Baird, B. Interactions between FcɛRI and lipid raft components are regulated by the actin cytoskeleton. J. Cell Sci. 113, 1009–1019 (2000).",{"doi":3899},"10.1242\u002Fjcs.113.6.1009",{"id":28,"text":3901,"url":28,"identifiers":3902},"Sheets, E. D., Holowka, D. & Baird, B. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcɛRI and their association with detergent-resistant membranes. J. Cell Biol. 145, 877– 887 (1999).This paper is the culmination of a series of studies showing the role of rafts in IgE receptor signalling.",{"doi":3903},"10.1083\u002Fjcb.145.4.877",{"id":28,"text":3905,"url":28,"identifiers":3906},"Goitsuka, R. et al. A BASH\u002FSLP-76-related adaptor protein MIST\u002FClnk involved in IgE receptor-mediated mast cell degranulation. Int. Immunol. 12, 573–580 (2000).",{"doi":3907},"10.1093\u002Fintimm\u002F12.4.573",{"id":28,"text":3909,"url":28,"identifiers":3910},"Janes, P. W., Ley, S. C., Magee, A. I. & Kabouridis, P. S. The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin. Immunol. 12, 23–34 ( 2000).",{"doi":3911},"10.1006\u002Fsmim.2000.0204",{"id":28,"text":3913,"url":28,"identifiers":3914},"Langlet, C., Bernard, A. M., Drevot, P. & He, H. T. Membrane rafts and signaling by the multichain immune recognition receptors . Curr. Opin. Immunol. 12, 250– 255 (2000).",{"doi":3915},"10.1016\u002FS0952-7915(00)00084-4",{"id":28,"text":3917,"url":28,"identifiers":3918},"Zhang, W., Trible, R. P. & Samelson, L. E. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation . Immunity 9, 239–246 (1998).",{"doi":3919},"10.1016\u002FS1074-7613(00)80606-8",{"id":28,"text":3921,"url":28,"identifiers":3922},"Brdicka, T., Cerny, J. & Horejsi, V. T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains. Biochem. Biophys. Res. Commun. 248, 356–360 (1998).",{"doi":3923},"10.1006\u002Fbbrc.1998.8857",{"id":28,"text":3925,"url":28,"identifiers":3926},"Lin, J., Weiss, A. & Finco, T. S. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J. Biol. Chem. 274 , 28861–28864 (1999).",{"doi":3927},"10.1074\u002Fjbc.274.41.28861",{"id":28,"text":3929,"url":28,"identifiers":3930},"Moran, M. & Miceli, M. C. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation. Immunity 9, 787–796 (1998).",{"doi":3931},"10.1016\u002FS1074-7613(00)80644-5",{"id":28,"text":3933,"url":28,"identifiers":3934},"Stefanova, I., Horejsi, V., Ansotegui, I. J., Knapp, W. & Stockinger, H. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254, 1016–1019 (1991).",{"doi":3935},"10.1126\u002Fscience.1719635",{"id":28,"text":3937,"url":28,"identifiers":3938},"Montixi, C. et al. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17, 5334–5348 (1998).",{"doi":3939},"10.1093\u002Femboj\u002F17.18.5334",{"id":28,"text":3941,"url":28,"identifiers":3942},"Xavier, R., Brennan, T., Li, Q., McCormack, C. & Seed, B. Membrane compartmentation is required for efficient T cell activation. Immunity 8, 723– 732 (1998).Detailed characterization of several proteins participating in T-cell activation and their raft association.",{"doi":3943},"10.1016\u002FS1074-7613(00)80577-4",{"id":28,"text":3945,"url":28,"identifiers":3946},"Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains . Science 283, 680–682 (1999).Antibody-coated beads are used to activate clustering of raft components in T-cell signalling.",{"doi":3947},"10.1126\u002Fscience.283.5402.680",{"id":28,"text":3949,"url":28,"identifiers":3950},"Cary, L. A. & Cooper, J. A. Molecular switches in lipid rafts . Nature 404, 945–947 (2000).",{"doi":3951},"10.1038\u002F35010257",{"id":28,"text":3953,"url":28,"identifiers":3954},"Lanzavecchia, A., Lezzi, G. & Viola, A. From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell 96, 1– 4 (1999).",{"doi":3955},"10.1016\u002FS0092-8674(00)80952-6",{"id":28,"text":3957,"url":28,"identifiers":3958},"van der Merwe, A. P., Davis, S. J., Shaw, A. S. & Dustin, M. L. Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition. Semin. Immunol. 12, 5–21 (2000).",{"doi":3959},"10.1006\u002Fsmim.2000.0203",{"id":28,"text":3961,"url":28,"identifiers":3962},"Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221– 227 (1999).",{"doi":3963},"10.1126\u002Fscience.285.5425.221",{"id":28,"text":3965,"url":28,"identifiers":3966},"Zhang, W. & Samelson, L. E. The role of membrane-associated adaptors in T cell receptor signalling. Semin. Immunol. 12, 35–41 (2000).",{"doi":3967},"10.1006\u002Fsmim.2000.0205",{"id":28,"text":3969,"url":28,"identifiers":3970},"Anderson, H. A., Hiltbold, E. M. & Roche, P. A. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nature Immunol. 1, 156–162 (2000).",{"doi":3971},"10.1038\u002F77842",{"id":28,"text":3973,"url":28,"identifiers":3974},"Tansey, M. G., Baloh, R. H., Milbrandt, J. & Johnson, E. M. Jr GFRα-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron 25, 611– 623 (2000).The demonstration that GDNF signalling is a raft-dependent process.",{"doi":3975},"10.1016\u002FS0896-6273(00)81064-8",{"id":28,"text":3977,"url":28,"identifiers":3978},"Poteryaev, D. et al. GDNF triggers a novel ret-independent src kinase family-coupled signaling via a GPI-linked GDNF receptor α1. FEBS Lett. 463, 63–66 (1999).",{"doi":3979},"10.1016\u002FS0014-5793(99)01590-2",{"id":28,"text":3981,"url":28,"identifiers":3982},"Trupp, M., Scott, R., Whittemore, S. R. & Ibanez, C. F. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J. Biol. Chem. 274, 20885–20894 (1999).",{"doi":3983},"10.1074\u002Fjbc.274.30.20885",{"id":28,"text":3985,"url":28,"identifiers":3986},"Roy, S. et al. Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nature Cell Biol. 1, 98–105 (1999). This paper shows that H-Ras signals in rafts and K-Ras signals outside rafts.",{"doi":3987},"10.1038\u002F10067",{"id":28,"text":3989,"url":28,"identifiers":3990},"Hancock, J. F., Paterson, H. & Marshall, C. J. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63, 133–139 ( 1990).",{"doi":3991},"10.1016\u002F0092-8674(90)90294-O",{"id":28,"text":3993,"url":28,"identifiers":3994},"Incardona, J. P. & Eaton, S. Cholesterol in signal transduction. Curr. Opin. Cell Biol. 12, 193–203 (2000).",{"doi":3995},"10.1016\u002FS0955-0674(99)00076-9",{"id":28,"text":3997,"url":28,"identifiers":3998},"Porter, J. A., Young, K. E. & Beachy, P. A. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255– 259 (1996).",{"doi":3999},"10.1126\u002Fscience.274.5285.255",{"id":28,"text":4001,"url":28,"identifiers":4002},"Pepinsky, R. B. et al. Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273, 14037– 14045 (1998).",{"doi":4003},"10.1074\u002Fjbc.273.22.14037",{"id":28,"text":4005,"url":28,"identifiers":4006},"Burke, R. et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 99, 803–815 ( 1999).",{"doi":4007},"10.1016\u002FS0092-8674(00)81677-3",{"id":28,"text":4009,"url":28,"identifiers":4010},"Harder, T. & Simons, K. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. 29, 556 –562 (1999).",{"doi":4011},"10.1002\u002F(SICI)1521-4141(199902)29:02\u003C556::AID-IMMU556>3.0.CO;2-2",{"id":28,"text":4013,"url":28,"identifiers":4014},"Laux, T. et al. GAP43, MARCKS, and CAP23 modulate PI(4,5)P2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism . J. Cell Biol. 149, 1455– 1472 (2000).",{"doi":4015},"10.1083\u002Fjcb.149.7.1455",{"id":28,"text":4017,"url":28,"identifiers":4018},"Pike, L. J. & Miller, J. M. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273, 22298– 22304 (1998).",{"doi":4019},"10.1074\u002Fjbc.273.35.22298",{"id":28,"text":4021,"url":28,"identifiers":4022},"Rozelle, A. L. et al. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2\u002F3. Curr. Biol. 10, 311–320 ( 2000).",{"doi":4023},"10.1016\u002FS0960-9822(00)00384-5",{"id":28,"text":4025,"url":28,"identifiers":4026},"Iwabuchi, K., Yamamura, S., Prinetti, A., Handa, K. & Hakomori, S. GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate–carbohydrate interaction in mouse melanoma B16 cells. J. Biol. Chem. 273, 9130–9138 (1998).",{"doi":4027},"10.1074\u002Fjbc.273.15.9130",{"id":28,"text":4029,"url":28,"identifiers":4030},"Roper, K., Corbeil, D. & Huttner, W. B. Retention of prominin in microvilli reveals distinct cholesterol–based lipid microdomains within the apical plasma membrane of epithelial cells. Nature Cell Biol. 2, 582–592 (2000).",{"doi":4031},"10.1038\u002F35023524",{"id":28,"text":4033,"url":28,"identifiers":4034},"Mayor, S., Rothberg, K. G. & Maxfield, F. R. Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking. Science 264, 1948–1951 (1994).",{"doi":4035},"10.1126\u002Fscience.7516582",{"id":28,"text":4037,"url":28,"identifiers":4038},"Parton, R. G. Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae . J. Histochem. Cytochem. 42, 155– 166 (1994).",{"doi":3457},{"id":28,"text":4040,"url":28,"identifiers":4041},"Fujimoto, T. GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after crosslinking. J. Histochem. Cytochem. 44, 929–941 (1996).",{"doi":4042},"10.1177\u002F44.8.8756764",{"id":28,"text":4044,"url":28,"identifiers":4045},"Wilson, B. S., Pfeiffer, J. R. & Oliver, J. M. Observing FceRI signaling from the inside of the mast cell membrane. J. Cell Biol. 149, 1131 –1142 (2000).Clear visualization of raft clustering during IgE signalling by immuno-electron microscopy.",{"doi":4046},"10.1083\u002Fjcb.149.5.1131",{"id":28,"text":4048,"url":28,"identifiers":4049},"Sargiacomo, M., Sudol, M., Tang, Z. & Lisanti, M. P. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J. Cell Biol. 122, 789–807 (1993).",{"doi":4050},"10.1083\u002Fjcb.122.4.789",{"id":28,"text":4052,"url":28,"identifiers":4053},"Kurzchalia, T., Hartmann, E. & Dupree, P. Guilt by insolubility: Does a protein's detergent insolubility reflect caveolar location. Trends Cell Biol. 5, 187–189 (1995).",{},{"id":28,"text":4055,"url":28,"identifiers":4056},"Smart, E. J., Ying, Y. S., Mineo, C. & Anderson, R. G. A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc. Natl Acad. Sci. USA 92, 10104– 10108 (1995).",{"doi":4057},"10.1073\u002Fpnas.92.22.10104",{"id":28,"text":4059,"url":28,"identifiers":4060},"Schnitzer, J. E., McIntosh, D. P., Dvorak, A. M., Liu, J. & Oh, P. Separation of caveolae from associated microdomains of GPI-anchored proteins. Science 269, 1435–1439 (1995).",{"doi":4061},"10.1126\u002Fscience.7660128",{"id":28,"text":4063,"url":28,"identifiers":4064},"Stan, R. V. et al. Immunoisolation and partial characterization of endothelial plasmalemmal vesicles (caveolae). Mol. Biol. Cell 8 , 595–605 (1997).",{"doi":4065},"10.1091\u002Fmbc.8.4.595",{"id":28,"text":4067,"url":28,"identifiers":4068},"Oh, P. & Schnitzer, J. E. Immunoisolation of caveolae with high affinity antibody binding to the oligomeric caveolin cage. Toward understanding the basis of purification. J. Biol. Chem. 274, 23144–23154 (1999).",{"doi":4069},"10.1074\u002Fjbc.274.33.23144",{"id":28,"text":4071,"url":28,"identifiers":4072},"Kurzchalia, T. V. & Parton, R. G. Membrane microdomains and caveolae. Curr. Opin. Cell Biol. 11, 424–431 (1999).",{"doi":4073},"10.1016\u002FS0955-0674(99)80061-1",{"id":28,"text":4075,"url":28,"identifiers":4076},"Schutz, G. J., Kada, G., Pastushenko, V. P. & Schindler, H. Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy. EMBO J. 19, 892– 901 (2000).",{"doi":4077},"10.1093\u002Femboj\u002F19.5.892",{"id":28,"text":4079,"url":28,"identifiers":4080},"Cheng, P. C., Dykstra, M. L., Mitchell, R. N. & Pierce, S. K. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting . J. Exp. Med. 190, 1549– 1560 (1999).",{"doi":4081},"10.1084\u002Fjem.190.11.1549",{"id":28,"text":4083,"url":28,"identifiers":4084},"Couet, J., Sargiacomo, M. & Lisanti, M. P. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine\u002Fthreonine kinase activities. J. Biol. Chem. 272, 30429 –30438 (1997).",{"doi":4085},"10.1074\u002Fjbc.272.48.30429",{"id":28,"text":4087,"url":28,"identifiers":4088},"Mastick, C. C., Brady, M. J. & Saltiel, A. R. Insulin stimulates the tyrosine phosphorylation of caveolin. J. Cell Biol. 129, 1523– 1531 (1995).",{"doi":4089},"10.1083\u002Fjcb.129.6.1523",{"id":28,"text":4091,"url":28,"identifiers":4092},"Bruckner, K. et al. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22, 511 –524 (1999).",{"doi":4093},"10.1016\u002FS0896-6273(00)80706-0",{"id":28,"text":4095,"url":28,"identifiers":4096},"Bilderback, T. R., Gazula, V. R., Lisanti, M. P. & Dobrowsky, R. T. Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways. J. Biol. Chem. 274, 257– 263 (1999).",{"doi":4097},"10.1074\u002Fjbc.274.1.257",{"id":28,"text":4099,"url":28,"identifiers":4100},"Wary, K. K., Mariotti, A., Zurzolo, C. & Giancotti, F. G. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94, 625–634 (1998).",{"doi":4101},"10.1016\u002FS0092-8674(00)81604-9",{"id":28,"text":4103,"url":28,"identifiers":4104},"Krauss, K. & Altevogt, P. Integrin leukocyte function-associated antigen-1 mediated cell binding can be activated by clustering of membrane rafts. J. Biol. Chem. 274, 36921– 36927 (1999).",{"doi":4105},"10.1074\u002Fjbc.274.52.36921",{"id":28,"text":4107,"url":28,"identifiers":4108},"Shaul, P. W. et al. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J. Biol. Chem. 271, 6518– 6522 (1996).",{"doi":4109},"10.1074\u002Fjbc.271.11.6518",{"id":28,"text":4111,"url":28,"identifiers":4112},"Garcia-Cardena, G., Fan, R., Stern, D. F., Liu, J. & Sessa, W. C. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J. Biol. Chem. 271, 27237–27240 (1996).",{"doi":4113},"10.1074\u002Fjbc.271.44.27237",{"id":4115,"createTime":4116,"updateTime":4116,"relativeEntities":4117,"slug":4118,"properties":4119,"entityType":971,"verifyStatus":26,"verifyTime":4116,"verifyNote":972,"languages":4130,"translateLanguages":28,"viewCount":32,"primaryUrl":4131,"fullTextUrl":28,"authors":4132,"publicationType":1063,"publisherRelationship":4171,"citationCount":4226,"citationInfo":4227,"publishDate":4240,"publishYear":4228,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":4241,"openAccess":28,"references":4242,"isForceReanalyzing":1713},"1c165258-5175-4f8d-bf3f-db422ad0f29e","2024-10-08T23:48:23.798+00:00",[],"Signal-integration-in-the-endoplasmic-reticulum-unfolded-protein-response",{"openalex":4120,"mag":4122,"title":4124,"pm":4126,"doi":4128},{"VOID":4121},"W2089198803",{"VOID":4123},"2089198803",{"EN":4125},"Signal integration in the endoplasmic reticulum unfolded protein 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Y., Segal, M., Normington, K., Gething, M. J. & Sambrook, J. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332, 462–464 (1988).",{"doi":4246},"10.1038\u002F332462a0",{"id":28,"text":4248,"url":28,"identifiers":4249},"Schroder, M. & Kaufman, R. J. The mammalian unfolded protein response. Annu. Rev. Biochem. 74, 739–789 (2005).",{"doi":4250},"10.1146\u002Fannurev.biochem.73.011303.074134",{"id":28,"text":4252,"url":28,"identifiers":4253},"Bernales, S., Papa, F. R. & Walter, P. Intracellular signaling by the unfolded protein response. Annu. Rev. Cell. Dev. Biol. 22, 487–508 (2006).",{"doi":4254},"10.1146\u002Fannurev.cellbio.21.122303.120200",{"id":28,"text":4256,"url":28,"identifiers":4257},"Cox, J. S., Shamu, C. E. & Walter, P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197–1206 (1993).",{"doi":4258},"10.1016\u002F0092-8674(93)90648-A",{"id":28,"text":4260,"url":28,"identifiers":4261},"Mori, K., Ma, W., Gething, M. J. & Sambrook, J. A transmembrane protein with a cdc2+\u002FCDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 74, 743–756 (1993). References 4 and 5 report the cloning of IRE1, the first component of the unfolded protein response to be identified.",{"doi":4262},"10.1016\u002F0092-8674(93)90521-Q",{"id":28,"text":4264,"url":28,"identifiers":4265},"Credle, J. J., Finer-Moore, J. S., Papa, F. R., Stroud, R. M. & Walter, P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc. Natl Acad. Sci. USA 102, 18773–18784 (2005).",{"doi":4266},"10.1073\u002Fpnas.0509487102",{"id":28,"text":4268,"url":28,"identifiers":4269},"Zhou, J. et al. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl Acad. Sci. USA 103, 14343–14348 (2006). References 6 and 7 provide the first structural insight into the detection of the endoplasmic reticulum stress signal.",{"doi":4270},"10.1073\u002Fpnas.0606480103",{"id":28,"text":4272,"url":28,"identifiers":4273},"Shamu, C. E. & Walter, P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 15, 3028–3039 (1996).",{"doi":4274},"10.1002\u002Fj.1460-2075.1996.tb00666.x",{"id":28,"text":4276,"url":28,"identifiers":4277},"Papa, F. R., Zhang, C., Shokat, K. & Walter, P. Bypassing a kinase activity with an ATP-competitive drug. Science 302, 1533–1537 (2003).",{"doi":4278},"10.1126\u002Fscience.1090031",{"id":28,"text":4280,"url":28,"identifiers":4281},"Cox, J. S. & Walter, P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87, 391–404 (1996).",{"doi":4282},"10.1016\u002FS0092-8674(00)81360-4",{"id":28,"text":4284,"url":28,"identifiers":4285},"Mori, K., Kawahara, T., Yoshida, H., Yanagi, H. & Yura, T. Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells 1, 803–817 (1996).",{"doi":4286},"10.1046\u002Fj.1365-2443.1996.d01-274.x",{"id":28,"text":4288,"url":28,"identifiers":4289},"Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881–891 (2001).",{"doi":4290},"10.1016\u002FS0092-8674(01)00611-0",{"id":28,"text":4292,"url":28,"identifiers":4293},"Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92–96 (2002).",{"doi":4294},"10.1038\u002F415092a",{"id":28,"text":4296,"url":28,"identifiers":4297},"Sidrauski, C., Cox, J. S. & Walter, P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87, 405–413 (1996).",{"doi":4298},"10.1016\u002FS0092-8674(00)81361-6",{"id":28,"text":4300,"url":28,"identifiers":4301},"Stephens, S. B. et al. Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. Mol. Biol. Cell 16, 5819–5831 (2005).",{"doi":4302},"10.1091\u002Fmbc.e05-07-0685",{"id":28,"text":4304,"url":28,"identifiers":4305},"Ruegsegger, U., Leber, J. H. & Walter, P. Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell 107, 103–114 (2001).",{"doi":4306},"10.1016\u002FS0092-8674(01)00505-0",{"id":28,"text":4308,"url":28,"identifiers":4309},"Yoshida, H., Oku, M., Suzuki, M. & Mori, K. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J. Cell Biol. 172, 565–575 (2006).",{"doi":4310},"10.1083\u002Fjcb.200508145",{"id":28,"text":4312,"url":28,"identifiers":4313},"Leber, J. H., Bernales, S. & Walter, P. IRE1-independent gain control of the unfolded protein response. PLoS Biol. 2, e235 (2004).",{"doi":4314},"10.1371\u002Fjournal.pbio.0020235",{"id":28,"text":4316,"url":28,"identifiers":4317},"Niwa, M., Patil, C. K., DeRisi, J. & Walter, P. Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease. Genome Biol. 6, R3 (2005).",{"doi":4318},"10.1186\u002Fgb-2004-6-1-r3",{"id":28,"text":4320,"url":28,"identifiers":4321},"Nekrutenko, A. & He, J. Functionality of unspliced XBP1 is required to explain evolution of overlapping reading frames. Trends Genet. 22, 645–648 (2006).",{"doi":4322},"10.1016\u002Fj.tig.2006.09.012",{"id":28,"text":4324,"url":28,"identifiers":4325},"Shen, X., Ellis, R. E., Sakaki, K. & Kaufman, R. J. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet. 1, e37 (2005).",{"doi":4326},"10.1371\u002Fjournal.pgen.0010037",{"id":28,"text":4328,"url":28,"identifiers":4329},"Urano, F. et al. Coupling of stress in the endoplasmic reticulum to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664–666 (2000).",{"doi":4330},"10.1126\u002Fscience.287.5453.664",{"id":28,"text":4332,"url":28,"identifiers":4333},"Yoneda, T. et al. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor-2- dependent mechanism in response to the ER stress. J. Biol. Chem. 276, 13935–13940 (2001).",{"doi":4334},"10.1074\u002Fjbc.M010677200",{"id":28,"text":4336,"url":28,"identifiers":4337},"Hetz, C. et al. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α. Science 312, 572–576 (2006).",{"doi":4338},"10.1126\u002Fscience.1123480",{"id":28,"text":4340,"url":28,"identifiers":4341},"Nishitoh, H. et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16, 1345–1355 (2002).",{"doi":4342},"10.1101\u002Fgad.992302",{"id":28,"text":4344,"url":28,"identifiers":4345},"Hollien, J. & Weissman, J. S. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 313, 104–107 (2006).",{"doi":4346},"10.1126\u002Fscience.1129631",{"id":28,"text":4348,"url":28,"identifiers":4349},"Haze, K., Yoshida, H., Yanagi, H., Yura, T. & Mori, K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 10, 3787–3799 (1999). Reference 27 reports the identification of ATF6.",{"doi":4350},"10.1091\u002Fmbc.10.11.3787",{"id":28,"text":4352,"url":28,"identifiers":4353},"Ye, J. et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6, 1355–1364 (2000).",{"doi":4354},"10.1016\u002FS1097-2765(00)00133-7",{"id":28,"text":4356,"url":28,"identifiers":4357},"Shen, J., Chen, X., Hendershot, L. & Prywes, R. ER stress regulation of ATF6 localization by dissociation of BiP\u002FGRP78 and unmasking of Golgi localization signals. Dev. Cell 3, 99–111 (2002).",{"doi":4358},"10.1016\u002FS1534-5807(02)00203-4",{"id":28,"text":4360,"url":28,"identifiers":4361},"Zhang, K. et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587–599 (2006).",{"doi":4362},"10.1016\u002Fj.cell.2005.11.040",{"id":28,"text":4364,"url":28,"identifiers":4365},"Bertolotti, A., Zhang, Y., Hendershot, L., Harding, H. & Ron, D. Dynamic interaction of BiP and the ER stress transducers in the unfolded protein response. Nature Cell Biol. 2, 326–332 (2000).",{"doi":4366},"10.1038\u002F35014014",{"id":28,"text":4368,"url":28,"identifiers":4369},"Harding, H., Zhang, Y. & Ron, D. Translation and protein folding are coupled by an endoplasmic reticulum resident kinase. Nature 397, 271–274 (1999). Reference 32 reports the identification of PERK.",{"doi":4370},"10.1038\u002F16729",{"id":28,"text":4372,"url":28,"identifiers":4373},"Harding, H. et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 11, 619–633 (2003).",{"doi":4374},"10.1016\u002FS1097-2765(03)00105-9",{"id":28,"text":4376,"url":28,"identifiers":4377},"Scheuner, D. et al. Translational control is required for the unfolded protein response and in-vivo glucose homeostasis. Mol. Cell 7, 1165–1176 (2001). Reference 34 reports the special role of eIF2a phosphorylation in preserving secretory cell viability and function.",{"doi":4378},"10.1016\u002FS1097-2765(01)00265-9",{"id":28,"text":4380,"url":28,"identifiers":4381},"Lu, P. D. et al. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 23, 169–179 (2004).",{"doi":4382},"10.1038\u002Fsj.emboj.7600030",{"id":28,"text":4384,"url":28,"identifiers":4385},"Hinnebusch, A. G. & Natarajan, K. Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot. Cell 1, 22–32 (2002).",{"doi":4386},"10.1128\u002FEC.01.1.22-32.2002",{"id":28,"text":4388,"url":28,"identifiers":4389},"Vattem, K. M. & Wek, R. C. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc. Natl Acad. Sci. USA 101, 11269–11274 (2004).",{"doi":4390},"10.1073\u002Fpnas.0400541101",{"id":28,"text":4392,"url":28,"identifiers":4393},"Lu, P. D., Harding, H. P. & Ron, D. Translation re-initiation at alternative open reading frames regulates gene expression in an integrated stress response. J. Cell Biol. 167, 27–33 (2004).",{"doi":4394},"10.1083\u002Fjcb.200408003",{"id":28,"text":4396,"url":28,"identifiers":4397},"Jiang, H. Y. et al. Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses. Mol. Cell. Biol. 23, 5651–5663 (2003).",{"doi":4398},"10.1128\u002FMCB.23.16.5651-5663.2003",{"id":28,"text":4400,"url":28,"identifiers":4401},"Deng, J. et al. Translational repression mediates activation of nuclear factor κB by phosphorylated translation initiation factor 2. Mol. Cell. Biol. 24, 10161–10168 (2004).",{"doi":4402},"10.1128\u002FMCB.24.23.10161-10168.2004",{"id":28,"text":4404,"url":28,"identifiers":4405},"Jousse, C. et al. Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells. J. Cell Biol. 163, 767–775 (2003).",{"doi":4406},"10.1083\u002Fjcb.200308075",{"id":28,"text":4408,"url":28,"identifiers":4409},"Connor, J. H., Weiser, D. C., Li, S., Hallenbeck, J. M. & Shenolikar, S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol. Cell. Biol. 21, 6841–6850 (2001).",{"doi":4410},"10.1128\u002FMCB.21.20.6841-6850.2001",{"id":28,"text":4412,"url":28,"identifiers":4413},"Novoa, I., Zeng, H., Harding, H. & Ron, D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α. J. Cell Biol. 153, 1011–1022 (2001).",{"doi":4414},"10.1083\u002Fjcb.153.5.1011",{"id":28,"text":4416,"url":28,"identifiers":4417},"Ma, Y. & Hendershot, L. M. Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J. Biol. Chem. 278, 34864–34873 (2003).",{"doi":4418},"10.1074\u002Fjbc.M301107200",{"id":28,"text":4420,"url":28,"identifiers":4421},"Brush, M. H., Weiser, D. C. & Shenolikar, S. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1α to the endoplasmic reticulum and promotes dephosphorylation of the α subunit of eukaryotic translation initiation factor 2. Mol. Cell. Biol. 23, 1292–1303 (2003).",{"doi":4422},"10.1128\u002FMCB.23.4.1292-1303.2003",{"id":28,"text":4424,"url":28,"identifiers":4425},"Novoa, I. et al. Stress-induced gene expression requires programmed recovery from translational repression. EMBO J. 22, 1180–1187 (2003).",{"doi":4426},"10.1093\u002Femboj\u002Fcdg112",{"id":28,"text":4428,"url":28,"identifiers":4429},"Harding, H. et al. Diabetes mellitus and exocrine pancreatic dysfunction in Perk−\u002F− mice reveals a role for translational control in survival of secretory cells. Mol. Cell 7, 1153–1163 (2001).",{"doi":4430},"10.1016\u002FS1097-2765(01)00264-7",{"id":28,"text":4432,"url":28,"identifiers":4433},"Yoshida, H. et al. A time-dependent phase shift in the mammalian unfolded protein response. Dev. Cell 4, 265–271 (2003).",{"doi":4434},"10.1016\u002FS1534-5807(03)00022-4",{"id":28,"text":4436,"url":28,"identifiers":4437},"Patil, C. K., Li, H. & Walter, P. Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. PLoS Biol. 2, e246 (2004).",{"doi":4438},"10.1371\u002Fjournal.pbio.0020246",{"id":28,"text":4440,"url":28,"identifiers":4441},"Travers, K. J. et al. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101, 249–258 (2000).",{"doi":4442},"10.1016\u002FS0092-8674(00)80835-1",{"id":28,"text":4444,"url":28,"identifiers":4445},"Murray, J. I. et al. Diverse and specific gene expression responses to stresses in cultured human cells. Mol. Biol. Cell 15, 2361–2374 (2004).",{"doi":4446},"10.1091\u002Fmbc.e03-11-0799",{"id":28,"text":4448,"url":28,"identifiers":4449},"Harding, H. et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6, 1099–1108 (2000). Reference 52 reports the role of eIF2a phosphorylation in regulating gene expression in the unfolded protein response.",{"doi":4450},"10.1016\u002FS1097-2765(00)00108-8",{"id":28,"text":4452,"url":28,"identifiers":4453},"Brodsky, J. L., Goeckeler, J. & Schekman, R. BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum. Proc. Natl Acad. Sci. USA 92, 9643–9646 (1995).",{"doi":4454},"10.1073\u002Fpnas.92.21.9643",{"id":28,"text":4456,"url":28,"identifiers":4457},"Kang, S.-W. et al. Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell 127, 999–1013 (2006).",{"doi":4458},"10.1016\u002Fj.cell.2006.10.032",{"id":28,"text":4460,"url":28,"identifiers":4461},"Cox, J. S., Chapman, R. E. & Walter, P. The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. Mol. Biol. Cell 8, 1805–1814 (1997).",{"doi":4462},"10.1091\u002Fmbc.8.9.1805",{"id":28,"text":4464,"url":28,"identifiers":4465},"Reimold, A. M. et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412, 300–307 (2001).",{"doi":4466},"10.1038\u002F35085509",{"id":28,"text":4468,"url":28,"identifiers":4469},"Lee, A. H., Chu, G. C., Iwakoshi, N. N. & Glimcher, L. H. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J. 24, 4368–4380 (2005).",{"doi":4470},"10.1038\u002Fsj.emboj.7600903",{"id":28,"text":4472,"url":28,"identifiers":4473},"Shaffer, A. L. et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21, 81–93 (2004).",{"doi":4474},"10.1016\u002Fj.immuni.2004.06.010",{"id":28,"text":4476,"url":28,"identifiers":4477},"Sriburi, R., Jackowski, S., Mori, K. & Brewer, J. W. XBP1: a link between the unfolded protein response, lipid biosynthesis and biogenesis of the endoplasmic reticulum. J. Cell Biol. 167, 35–41 (2004). References 58 and 59 report the role of the unfolded protein response in the acquisition of a secretory cell phenotype.",{"doi":4478},"10.1083\u002Fjcb.200406136",{"id":28,"text":4480,"url":28,"identifiers":4481},"Bernales, S., McDonald, K. L. & Walter, P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol. 4, e423 (2006). Reference 60 reports the intersection of the unfolded protein response and autophagy.",{"doi":4482},"10.1371\u002Fjournal.pbio.0040423",{"id":28,"text":4484,"url":28,"identifiers":4485},"van der Sanden, M. H., Houweling, M., van Golde, L. M. & Vaandrager, A. B. Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT\u002Fenhancer-binding protein-homologous protein (CHOP\u002FGADD153). Biochem. J. 369, 643–650 (2003).",{"doi":4486},"10.1042\u002Fbj20020285",{"id":28,"text":4488,"url":28,"identifiers":4489},"Li, Y. et al. Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. J. Biol. Chem. 279, 37030–37039 (2004).",{"doi":4490},"10.1074\u002Fjbc.M405195200",{"id":28,"text":4492,"url":28,"identifiers":4493},"Feng, B. et al. The endoplasmic reticulum as the site of cholesterol-induced cytotoxicity in macrophages. Nature Cell Biol. 5, 781–792 (2003).",{"doi":4494},"10.1038\u002Fncb1035",{"id":28,"text":4496,"url":28,"identifiers":4497},"Harding, H. P. et al. Bioactive small molecules reveal antagonism between the integrated stress response and sterol regulated gene expression. Cell Metab. 2, 361–371 (2005).",{"doi":4498},"10.1016\u002Fj.cmet.2005.11.005",{"id":28,"text":4500,"url":28,"identifiers":4501},"Zeng, L. et al. ATF6 modulates SREBP2-mediated lipogenesis. EMBO J. 23, 950–958 (2004).",{"doi":4502},"10.1038\u002Fsj.emboj.7600106",{"id":28,"text":4504,"url":28,"identifiers":4505},"Ozcan, U. et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457–461 (2004).",{"doi":4506},"10.1126\u002Fscience.1103160",{"id":28,"text":4508,"url":28,"identifiers":4509},"Ozcan, U. et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137–1140 (2006).",{"doi":4510},"10.1126\u002Fscience.1128294",{"id":28,"text":4512,"url":28,"identifiers":4513},"Yorimitsu, T., Nair, U., Yang, Z. & Klionsky, D. J. Endoplasmic reticulum stress triggers autophagy. J. Biol. Chem. 281, 30299–30304 (2006).",{"doi":4514},"10.1074\u002Fjbc.M607007200",{"id":28,"text":4516,"url":28,"identifiers":4517},"Nakagawa, T. & Yuan, J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 150, 887–894 (2000).",{"doi":4518},"10.1083\u002Fjcb.150.4.887",{"id":28,"text":4520,"url":28,"identifiers":4521},"Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727–730 (2001).",{"doi":4522},"10.1126\u002Fscience.1059108",{"id":28,"text":4524,"url":28,"identifiers":4525},"Nakagawa, T. et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 403, 98–103 (2000).",{"doi":4526},"10.1038\u002F47513",{"id":28,"text":4528,"url":28,"identifiers":4529},"Rutkowski, D. T. et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 4, e374 (2006).",{"doi":4530},"10.1371\u002Fjournal.pbio.0040374",{"id":28,"text":4532,"url":28,"identifiers":4533},"Harding, H., Zhang, Y., Bertolotti, A., Zeng, H. & Ron, D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 5, 897–904 (2000).",{"doi":4534},"10.1016\u002FS1097-2765(00)80330-5",{"id":28,"text":4536,"url":28,"identifiers":4537},"McCullough, K. D., Martindale, J. L., Klotz, L. O., Aw, T. Y. & Holbrook, N. J. GADD153 sensitizes cells to endoplasmic reticulum stress by down- regulating BCL2 and perturbing the cellular redox state. Mol. Cell. Biol. 21, 1249–1259 (2001).",{"doi":4538},"10.1128\u002FMCB.21.4.1249-1259.2001",{"id":28,"text":4540,"url":28,"identifiers":4541},"Zinszner, H. et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 12, 982–995 (1998).",{"doi":4542},"10.1101\u002Fgad.12.7.982",{"id":28,"text":4544,"url":28,"identifiers":4545},"Oyadomari, S. et al. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Invest. 109, 525–532 (2002).",{"doi":4546},"10.1172\u002FJCI0214550",{"id":28,"text":4548,"url":28,"identifiers":4549},"Marciniak, S. J. et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18, 3066–3077 (2004).",{"doi":4550},"10.1101\u002Fgad.1250704",{"id":28,"text":4552,"url":28,"identifiers":4553},"Boyce, M. et al. A selective inhibitor of eIF2a dephosphorylation protects cells from ER stress. Science 307, 935–939 (2005).",{"doi":4554},"10.1126\u002Fscience.1101902",{"id":28,"text":4556,"url":28,"identifiers":4557},"Tan, S., Somia, N., Maher, P. & Schubert, D. Regulation of antioxidant metabolism by translation initiation factor 2α. J. Cell Biol. 152, 997–1006 (2001).",{"doi":4558},"10.1083\u002Fjcb.152.5.997",{"id":28,"text":4560,"url":28,"identifiers":4561},"Silva, R. et al. CHOP\u002FGADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J. Neurochem. 95, 974–986 (2005).",{"doi":4562},"10.1111\u002Fj.1471-4159.2005.03428.x",{"id":28,"text":4564,"url":28,"identifiers":4565},"Scheuner, D. et al. Double-stranded RNA-dependent protein kinase phosphorylation of the α-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J. Biol. Chem. 281, 21458–21468 (2006).",{"doi":4566},"10.1074\u002Fjbc.M603784200",{"id":28,"text":4568,"url":28,"identifiers":4569},"Fogli, A. et al. The effect of genotype on the natural history of eIF2B-related leukodystrophies. Neurology 62, 1509–1517 (2004).",{"doi":4570},"10.1212\u002F01.WNL.0000123259.67815.DB",{"id":28,"text":4572,"url":28,"identifiers":4573},"Sitia, R. & Braakman, I. Quality control in the endoplasmic reticulum protein factory. Nature 426, 891–894 (2003).",{"doi":4574},"10.1038\u002Fnature02262",{"id":28,"text":4576,"url":28,"identifiers":4577},"Sekijima, Y. et al. The biological and chemical basis for tissue-selective amyloid disease. Cell 121, 73–85 (2005).",{"doi":4578},"10.1016\u002Fj.cell.2005.01.018",{"id":28,"text":4580,"url":28,"identifiers":4581},"Okamura, K., Kimata, Y., Higashio, H., Tsuru, A. & Kohno, K. Dissociation of Kar2p\u002FBiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem. Biophys. Res. Commun. 279, 445–450 (2000).",{"doi":4582},"10.1006\u002Fbbrc.2000.3987",{"id":28,"text":4584,"url":28,"identifiers":4585},"Kimata, Y., Oikawa, D., Shimizu, Y., Ishiwata-Kimata, Y. & Kohno, K. A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J. Cell Biol. 167, 445–456 (2004).",{"doi":4586},"10.1083\u002Fjcb.200405153",{"id":28,"text":4588,"url":28,"identifiers":4589},"Ma, Y. & Hendershot, L. M. The role of the unfolded protein response in tumour development: friend or foe? Nature Rev. Cancer 4, 966–977 (2004).",{"doi":4590},"10.1038\u002Fnrc1505",{"id":28,"text":4592,"url":28,"identifiers":4593},"Queitsch, C., Sangster, T. A. & Lindquist, S. Hsp90 as a capacitor of phenotypic variation. Nature 417, 618–624 (2002).",{"doi":4594},"10.1038\u002Fnature749",{"id":28,"text":4596,"url":28,"identifiers":4597},"Koumenis, C. et al. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α. Mol. Cell. Biol. 22, 7405–7416 (2002).",{"doi":4598},"10.1128\u002FMCB.22.21.7405-7416.2002",{"id":28,"text":4600,"url":28,"identifiers":4601},"Koritzinsky, M. et al. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 25, 1114–1125 (2006).",{"doi":4602},"10.1038\u002Fsj.emboj.7600998",{"id":28,"text":4604,"url":28,"identifiers":4605},"Blais, J. D. et al. Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol. Cell. Biol. 24, 7469–7482 (2004).",{"doi":4606},"10.1128\u002FMCB.24.17.7469-7482.2004",{"id":28,"text":4608,"url":28,"identifiers":4609},"Bi, M. et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J. 24, 3470–3481 (2005).",{"doi":4610},"10.1038\u002Fsj.emboj.7600777",{"id":28,"text":4612,"url":28,"identifiers":4613},"Feldman, D. E., Chauhan, V. & Koong, A. C. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol. Cancer Res. 3, 597–605 (2005).",{"doi":4614},"10.1158\u002F1541-7786.MCR-05-0221",{"id":28,"text":4616,"url":28,"identifiers":4617},"Jamora, C., Dennert, G. & Lee, A. S. Inhibition of tumor progression by suppression of stress protein GRP78\u002FBiP induction in fibrosarcoma B\u002FC10ME. Proc. Natl Acad. Sci. USA 93, 7690–7694 (1996).",{"doi":4618},"10.1073\u002Fpnas.93.15.7690",{"id":28,"text":4620,"url":28,"identifiers":4621},"Blais, J. et al. PERK-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol. Cell Biol. 26, 9517–9532 (2006).",{"doi":4622},"10.1128\u002FMCB.01145-06",{"id":28,"text":4624,"url":28,"identifiers":4625},"Romero-Ramirez, L. et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 64, 5943–5947 (2004).",{"doi":4626},"10.1158\u002F0008-5472.CAN-04-1606",{"id":28,"text":4628,"url":28,"identifiers":4629},"Sidrauski, C. & Walter, P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90, 1031–1039 (1997).",{"doi":4630},"10.1016\u002FS0092-8674(00)80369-4",{"id":28,"text":4632,"url":28,"identifiers":4633},"Marciniak, S. J., Garcia-Bonilla, L., Hu, J., Harding, H. P. & Ron, D. Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. J. Cell Biol. 172, 201–209 (2006).",{"doi":4634},"10.1083\u002Fjcb.200508099",{"id":28,"text":4636,"url":28,"identifiers":4637},"Scheuner, D. et al. Control of mRNA translation preserves endoplasmic reticulum function in b cells and maintains glucose homeostasis. Nature Med. 11, 757–764 (2005).",{"doi":4638},"10.1038\u002Fnm1259",{"id":28,"text":4640,"url":28,"identifiers":4641},"Scorrano, L. et al. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 300, 135–139 (2003).",{"doi":4642},"10.1126\u002Fscience.1081208",{"id":4644,"createTime":4645,"updateTime":4645,"relativeEntities":4646,"slug":4647,"properties":4648,"entityType":971,"verifyStatus":26,"verifyTime":4645,"verifyNote":972,"languages":4659,"translateLanguages":28,"viewCount":32,"primaryUrl":4660,"fullTextUrl":28,"authors":4661,"publicationType":1063,"publisherRelationship":4725,"citationCount":4780,"citationInfo":4781,"publishDate":4790,"publishYear":4782,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":4791,"openAccess":28,"references":4792,"isForceReanalyzing":1713},"88f135fc-5a02-4248-af8e-0b4b4dd8aede","2024-10-16T19:16:16.149+00:00",[],"Shedding-light-on-the-cell-biology-of-extracellular-vesicles",{"openalex":4649,"mag":4651,"title":4653,"pm":4655,"doi":4657},{"VOID":4650},"W2786514708",{"VOID":4652},"2786514708",{"EN":4654},"Shedding light on the cell biology of extracellular vesicles",{"VOID":4656},"29339798",{"VOID":4658},"10.1038\u002Fnrm.2017.125",[31],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnrm.2017.125",[4662,4681,4708],{"id":4663,"sortIndex":32,"researcher":28,"roles":4664,"affiliations":4665,"properties":4674,"displayName":4678,"givenName":28,"familyName":28},"3e430feb-cb8f-4e2e-9bce-ce6f756e35ae",[],[4666],{"id":4667,"sortIndex":32,"affiliation":4668,"properties":28},"43532eb5-e10b-40b5-8df4-94f20ba06bc6",{"id":4667,"createTime":28,"updateTime":28,"relativeEntities":4669,"slug":28,"properties":4670,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":4673,"statistic":28},[],{"title":4671},{"EN":4672},"IPNP - 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S., Cheng, Y., Singh, P. P. & Smith, V. L. Exosomes and other extracellular vesicles in host-pathogen interactions. EMBO Rep. 16, 24–43 (2015).",{"doi":4796},"10.15252\u002Fembr.201439363",{"id":28,"text":4798,"url":28,"identifiers":4799},"Deatherage, B. L. & Cookson, B. T. Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life. Infect. Immun. 80, 1948–1957 (2012).",{"doi":4800},"10.1128\u002FIAI.06014-11",{"id":28,"text":4802,"url":28,"identifiers":4803},"Robinson, D. G., Ding, Y. & Jiang, L. Unconventional protein secretion in plants: a critical assessment. Protoplasma 253, 31–43 (2016).",{"doi":4804},"10.1007\u002Fs00709-015-0887-1",{"id":28,"text":4806,"url":28,"identifiers":4807},"Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L. & Turbide, C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem. 262, 9412–9420 (1987). This is the first report of exosomes as intraluminal vesicles of multivesicular endosomes that are secreted upon fusion of these endosomes with the plasma membrane, coining the term 'exosomes'.",{"doi":4808},"10.1016\u002FS0021-9258(18)48095-7",{"id":28,"text":4810,"url":28,"identifiers":4811},"Colombo, M., Raposo, G. & Thery, C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014).",{"doi":4812},"10.1146\u002Fannurev-cellbio-101512-122326",{"id":28,"text":4814,"url":28,"identifiers":4815},"Lo Cicero, A., Stahl, P. D. & Raposo, G. Extracellular vesicles shuffling intercellular messages: for good or for bad. Curr. Opin. Cell Biol. 35, 69–77 (2015).",{"doi":4816},"10.1016\u002Fj.ceb.2015.04.013",{"id":28,"text":4818,"url":28,"identifiers":4819},"Yanez-Mo, M. et al. Biological properties of extracellular vesicles and their physiological functions. J. Extracell. Vesicles 4, 27066 (2015).",{"doi":4820},"10.3402\u002Fjev.v4.27066",{"id":28,"text":4822,"url":28,"identifiers":4823},"Harding, C., Heuser, J. & Stahl, P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97, 329–339 (1983).",{"doi":4824},"10.1083\u002Fjcb.97.2.329",{"id":28,"text":4826,"url":28,"identifiers":4827},"Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol. http:\u002F\u002Fdx.doi.org\u002F10.1002\u002F0471143030.cb0322s30 (2006). This is the first exhaustive and detailed protocol providing isolation and characterization procedures of exosomes present in cell culture supernatants and biological fluids.",{"doi":4828},"10.1002\u002F0471143030.cb0322s30",{"id":28,"text":4830,"url":28,"identifiers":4831},"Raposo, G. & Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200, 373–383 (2013).",{"doi":4832},"10.1083\u002Fjcb.201211138",{"id":28,"text":4834,"url":28,"identifiers":4835},"Wasmuth, E. V., Januszyk, K. & Lima, C. D. Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. Nature 511, 435–439 (2014).",{"doi":4836},"10.1038\u002Fnature13406",{"id":28,"text":4838,"url":28,"identifiers":4839},"Trams, E. G., Lauter, C. J., Salem, N. Jr & Heine, U. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim. Biophys. Acta 645, 63–70 (1981).",{"doi":4840},"10.1016\u002F0005-2736(81)90512-5",{"id":28,"text":4842,"url":28,"identifiers":4843},"Harding, C., Heuser, J. & Stahl, P. Endocytosis and intracellular processing of transferrin and colloidal-gold transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding. Eur. J. Cell Biol. 35, 256–263 (1984).",{},{"id":28,"text":4845,"url":28,"identifiers":4846},"Pan, B. T., Teng, K., Wu, C., Adam, M. & Johnstone, R. M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 101, 942–948 (1985).",{"doi":4847},"10.1083\u002Fjcb.101.3.942",{"id":28,"text":4849,"url":28,"identifiers":4850},"Raposo, G. et al. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161–1172 (1996). Exploiting electron microscopy, biochemistry and functional assays, this manuscript shows for the first time that antigen-presenting cells secrete exosomes able to stimulate T cell proliferation.",{"doi":4851},"10.1084\u002Fjem.183.3.1161",{"id":28,"text":4853,"url":28,"identifiers":4854},"Zitvogel, L. et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. 4, 594–600 (1998). This study using tumour-bearing mice reports that exosomes secreted by dendritic cells induce antitumoural immune responses in vivo.",{"doi":4855},"10.1038\u002Fnm0598-594",{"id":28,"text":4857,"url":28,"identifiers":4858},"Wolf, P. The nature and significance of platelet products in human plasma. Br. J. Haematol. 13, 269–288 (1967).",{"doi":4859},"10.1111\u002Fj.1365-2141.1967.tb08741.x",{"id":28,"text":4861,"url":28,"identifiers":4862},"Stein, J. M. & Luzio, J. P. Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles. Biochem. J. 274, 381–386 (1991).",{"doi":4863},"10.1042\u002Fbj2740381",{"id":28,"text":4865,"url":28,"identifiers":4866},"Sims, P. J., Faioni, E. M., Wiedmer, T. & Shattil, S. J. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J. Biol. Chem. 263, 18205–18212 (1988).",{"doi":4867},"10.1016\u002FS0021-9258(19)81346-7",{"id":28,"text":4869,"url":28,"identifiers":4870},"Satta, N. et al. Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide. J. Immunol. 153, 3245–3255 (1994).",{"doi":4871},"10.4049\u002Fjimmunol.153.7.3245",{"id":28,"text":4873,"url":28,"identifiers":4874},"Al-Nedawi, K. et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 10, 619–624 (2008).",{"doi":4875},"10.1038\u002Fncb1725",{"id":28,"text":4877,"url":28,"identifiers":4878},"Tricario, C., Clancy, J. & De Souza-Schorey, C. Biology and biogenesis of shed microvesicles. Small GTPases 1–13 (2016).",{"doi":4879},"10.1080\u002F21541248.2016.1215283",{"id":28,"text":4881,"url":28,"identifiers":4882},"Willms, E. et al. Cells release subpopulations of exosomes with distinct molecular and biological properties. Sci. Rep. 6, 22519 (2016).",{"doi":4883},"10.1038\u002Fsrep22519",{"id":28,"text":4885,"url":28,"identifiers":4886},"Ma, L. et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 25, 24–38 (2015).",{"doi":4887},"10.1038\u002Fcr.2014.135",{"id":28,"text":4889,"url":28,"identifiers":4890},"Nabhan, J. F., Hu, R., Oh, R. S., Cohen, S. N. & Lu, Q. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc. Natl Acad. Sci. USA 109, 4146–4151 (2012).",{"doi":4891},"10.1073\u002Fpnas.1200448109",{"id":28,"text":4893,"url":28,"identifiers":4894},"Gould, S. J. & Raposo, G. As we wait: coping with an imperfect nomenclature for extracellular vesicles. J. Extracell. Vesicles 2, 20398 (2013).",{"doi":4895},"10.3402\u002Fjev.v2i0.20389",{"id":28,"text":4897,"url":28,"identifiers":4898},"Kowal, J. et al. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc. Natl Acad. Sci. USA 113, E968–E977 (2016).",{"doi":4899},"10.1073\u002Fpnas.1521230113",{"id":28,"text":4901,"url":28,"identifiers":4902},"Booth, A. M. et al. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J. Cell Biol. 172, 923–935 (2006).",{"doi":4903},"10.1083\u002Fjcb.200508014",{"id":28,"text":4905,"url":28,"identifiers":4906},"Gerber, P. P. et al. Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate. J. Cell Biol. 209, 435–452 (2015).",{"doi":4907},"10.1083\u002Fjcb.201409082",{"id":28,"text":4909,"url":28,"identifiers":4910},"Kalra, H., Drummen, G. P. & Mathivanan, S. Focus on extracellular vesicles: introducing the next small big thing. Int. J. Mol. Sci. 17, 170 (2016).",{"doi":4911},"10.3390\u002Fijms17020170",{"id":28,"text":4913,"url":28,"identifiers":4914},"Minciacchi, V. R., Freeman, M. R. & Di Vizio, D. Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin. Cell Dev. Biol. 40, 41–51 (2015).",{"doi":4915},"10.1016\u002Fj.semcdb.2015.02.010",{"id":28,"text":4917,"url":28,"identifiers":4918},"Ostrowski, M. et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 12, 19–30 (2010). This study uses a medium-throughput RNA-interference screen for RAB GTPases to reveal the involvement of RAB27 in exosome secretion, providing further evidence that exosomes derive from secretory multivesicular endosomes.",{"doi":4919},"10.1038\u002Fncb2000",{"id":28,"text":4921,"url":28,"identifiers":4922},"Berson, J. F., Harper, D., Tenza, D., Raposo, G. & Marks, M. S. Pmel17 initiates premelanosome morphogenesis within multivesicular bodies. Mol. Biol. Cell 12, 3451–3464 (2001).",{"doi":4923},"10.1091\u002Fmbc.12.11.3451",{"id":28,"text":4925,"url":28,"identifiers":4926},"Klumperman, J. & Raposo, G. The complex ultrastructure of the endolysosomal system. Cold Spring Harbor Perspect. Biol. 6, a016857 (2014).",{"doi":4927},"10.1101\u002Fcshperspect.a016857",{"id":28,"text":4929,"url":28,"identifiers":4930},"Vidal, M., Mangeat, P. & Hoekstra, D. Aggregation reroutes molecules from a recycling to a shedding pathway during reticulocyte maturation. J. Cell Sci. 110, 1867–1877 (1997).",{"doi":4931},"10.1242\u002Fjcs.110.16.1867",{"id":28,"text":4933,"url":28,"identifiers":4934},"Zimmermann, P. et al. Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6. Dev. Cell 9, 377–388 (2005).",{"doi":4935},"10.1016\u002Fj.devcel.2005.07.011",{"id":28,"text":4937,"url":28,"identifiers":4938},"Baietti, M. F. et al. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat. Cell Biol. 14, 677–685 (2012). This study reveals the involvement of a particular machinery required for exosome biogenesis and signalling through the interaction of ESCRTs, ALIX and syndecans.",{"doi":4939},"10.1038\u002Fncb2502",{"id":28,"text":4941,"url":28,"identifiers":4942},"D'Souza-Schorey, C. & Chavrier, P. ARF proteins: roles in membrane traffic and beyond. Nat. Rev. Mol. Cell Biol. 7, 347–358 (2006).",{"doi":4943},"10.1038\u002Fnrm1910",{"id":28,"text":4945,"url":28,"identifiers":4946},"Muralidharan-Chari, V. et al. ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr. Biol. 19, 1875–1885 (2009). This is the first report showing a mechanism for microvesicle release through the involvement of ARF6 and cytoskeletal rearrangements. It also shows that microvesicles but not exosomes carry metalloproteases able to digest the extracellular matrix.",{"doi":4947},"10.1016\u002Fj.cub.2009.09.059",{"id":28,"text":4949,"url":28,"identifiers":4950},"Wang, T. et al. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc. Natl Acad. Sci. USA 111, E3234–E3242 (2014).",{"doi":4951},"10.1073\u002Fpnas.1410041111",{"id":28,"text":4953,"url":28,"identifiers":4954},"Hurley, J. H. ESCRT complexes and the biogenesis of multivesicular bodies. Curr. Opin. Cell Biol. 20, 4–11 (2008).",{"doi":4955},"10.1016\u002Fj.ceb.2007.12.002",{"id":28,"text":4957,"url":28,"identifiers":4958},"Tamai, K. et al. Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. Biochem. Biophys. Res. Commun. 399, 384–390 (2010).",{"doi":4959},"10.1016\u002Fj.bbrc.2010.07.083",{"id":28,"text":4961,"url":28,"identifiers":4962},"Colombo, M. et al. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J. Cell Sci. 126, 5553–5565 (2013). This study uses a high-throughput RNA-interference screen targeting ESCRT subunits and accessory proteins to reveal a role for selected ESCRT components in modulation of exosome secretion and composition.",{"doi":4963},"10.1242\u002Fjcs.128868",{"id":28,"text":4965,"url":28,"identifiers":4966},"Stuffers, S., Sem Wegner, C., Stenmark, H. & Brech, A. Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 10, 925–937 (2009).",{"doi":4967},"10.1111\u002Fj.1600-0854.2009.00920.x",{"id":28,"text":4969,"url":28,"identifiers":4970},"Trajkovic, K. et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319, 1244–1247 (2008).",{"doi":4971},"10.1126\u002Fscience.1153124",{"id":28,"text":4973,"url":28,"identifiers":4974},"Goni, F. M. & Alonso, A. Effects of ceramide and other simple sphingolipids on membrane lateral structure. Biochim. Biophys. Acta 1788, 169–177 (2009).",{"doi":4975},"10.1016\u002Fj.bbamem.2008.09.002",{"id":28,"text":4977,"url":28,"identifiers":4978},"Kajimoto, T., Okada, T., Miya, S., Zhang, L. & Nakamura, S. Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. Nat. Commun. 4, 2712 (2013).",{"doi":4979},"10.1038\u002Fncomms3712",{"id":28,"text":4981,"url":28,"identifiers":4982},"Theos, A. C. et al. A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev. Cell 10, 343–354 (2006).",{"doi":4983},"10.1016\u002Fj.devcel.2006.01.012",{"id":28,"text":4985,"url":28,"identifiers":4986},"van Niel, G. et al. The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev. Cell 21, 708–721 (2011).",{"doi":4987},"10.1016\u002Fj.devcel.2011.08.019",{"id":28,"text":4989,"url":28,"identifiers":4990},"van Niel, G. et al. Apolipoprotein E regulates amyloid formation within endosomes of pigment cells. Cell Rep. 13, 43–51 (2015).",{"doi":4991},"10.1016\u002Fj.celrep.2015.08.057",{"id":28,"text":4993,"url":28,"identifiers":4994},"Gauthier, S. A. et al. Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities. Acta Neuropathol. Commun. 5, 65 (2017).",{"doi":4995},"10.1186\u002Fs40478-017-0466-0",{"id":28,"text":4997,"url":28,"identifiers":4998},"Buschow, S. I. et al. MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic 10, 1528–1542 (2009). This study reports that upon interaction with T cells, dendritic cells target MHC II molecules towards exosome secretion by using a multivesicular body pathway distinct from those employed by dendritic cells to target MHC II molecules towards lysosomal degradation.",{"doi":4999},"10.1111\u002Fj.1600-0854.2009.00963.x",{"id":28,"text":5001,"url":28,"identifiers":5002},"Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M. & Caplan, M. J. Exosome release of beta-catenin: a novel mechanism that antagonizes Wnt signaling. J. Cell Biol. 190, 1079–1091 (2010).",{"doi":5003},"10.1083\u002Fjcb.201002049",{"id":28,"text":5005,"url":28,"identifiers":5006},"Charrin, S., Jouannet, S., Boucheix, C. & Rubinstein, E. Tetraspanins at a glance. J. Cell Sci. 127, 3641–3648 (2014).",{"doi":5007},"10.1242\u002Fjcs.154906",{"id":28,"text":5009,"url":28,"identifiers":5010},"Zimmerman, B. et al. Crystal structure of a full-length human tetraspanin reveals a cholesterol-binding pocket. Cell 167, 1041–1051.e11 (2016).",{"doi":5011},"10.1016\u002Fj.cell.2016.09.056",{"id":28,"text":5013,"url":28,"identifiers":5014},"Odintsova, E. et al. Metastasis suppressor tetraspanin CD82\u002FKAI1 regulates ubiquitylation of epidermal growth factor receptor. J. Biol. Chem. 288, 26323–26334 (2013).",{"doi":5015},"10.1074\u002Fjbc.M112.439380",{"id":28,"text":5017,"url":28,"identifiers":5018},"Thery, C. et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 166, 7309–7318 (2001).",{"doi":5019},"10.4049\u002Fjimmunol.166.12.7309",{"id":28,"text":5021,"url":28,"identifiers":5022},"Geminard, C., De Gassart, A., Blanc, L. & Vidal, M. Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TfR for sorting into exosomes. Traffic 5, 181–193 (2004).",{"doi":5023},"10.1111\u002Fj.1600-0854.2004.0167.x",{"id":28,"text":5025,"url":28,"identifiers":5026},"de Gassart, A., Geminard, C., Fevrier, B., Raposo, G. & Vidal, M. Lipid raft-associated protein sorting in exosomes. Blood 102, 4336–4344 (2003).",{"doi":5027},"10.1182\u002Fblood-2003-03-0871",{"id":28,"text":5029,"url":28,"identifiers":5030},"Buschow, S. I., Liefhebber, J. M., Wubbolts, R. & Stoorvogel, W. Exosomes contain ubiquitinated proteins. Blood Cells Mol. Dis. 35, 398–403 (2005).",{"doi":5031},"10.1016\u002Fj.bcmd.2005.08.005",{"id":28,"text":5033,"url":28,"identifiers":5034},"Luhtala, N., Aslanian, A., Yates, J. R. 3rd & Hunter, T. Secreted glioblastoma nanovesicles contain intracellular signaling proteins and active Ras incorporated in a farnesylation-dependent manner. J. Biol. Chem. 292, 611–628 (2017).",{"doi":5035},"10.1074\u002Fjbc.M116.747618",{"id":28,"text":5037,"url":28,"identifiers":5038},"Valadi, H. et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9, 654–659 (2007). This article demonstrates that exosomes contain mRNAs and miRNAs and mediate their transfer between cells.",{"doi":5039},"10.1038\u002Fncb1596",{"id":28,"text":5041,"url":28,"identifiers":5042},"Nolte-'t Hoen, E. N. et al. Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions. Nucleic Acids Res. 40, 9272–9285 (2012).",{"doi":5043},"10.1093\u002Fnar\u002Fgks658",{"id":28,"text":5045,"url":28,"identifiers":5046},"Thakur, B. K. et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 24, 766–769 (2014).",{"doi":5047},"10.1038\u002Fcr.2014.44",{"id":28,"text":5049,"url":28,"identifiers":5050},"Kahlert, C. et al. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869–3875 (2014).",{"doi":5051},"10.1074\u002Fjbc.C113.532267",{"id":28,"text":5053,"url":28,"identifiers":5054},"Villarroya-Beltri, C. et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat. Commun. 4, 2980 (2013). This study shows that a ribonuclear sumoylated protein binds an RNA motif to promote the targeting of miRNA to exosomes.",{"doi":5055},"10.1038\u002Fncomms3980",{"id":28,"text":5057,"url":28,"identifiers":5058},"Mateescu, B. et al. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. J. Extracell. Vesicles 6, 1286095 (2017).",{"doi":5059},"10.1080\u002F20013078.2017.1286095",{"id":28,"text":5061,"url":28,"identifiers":5062},"Irion, U. & St Johnston, D. bicoid RNA localization requires specific binding of an endosomal sorting complex. Nature 445, 554–558 (2007).",{"doi":5063},"10.1038\u002Fnature05503",{"id":28,"text":5065,"url":28,"identifiers":5066},"Perez-Hernandez, D. et al. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. J. Biol. Chem. 288, 11649–11661 (2013).",{"doi":5067},"10.1074\u002Fjbc.M112.445304",{"id":28,"text":5069,"url":28,"identifiers":5070},"Gibbings, D. J., Ciaudo, C., Erhardt, M. & Voinnet, O. Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nature Cell Biol. 11, 1143–1149 (2009).",{"doi":5071},"10.1038\u002Fncb1929",{"id":28,"text":5073,"url":28,"identifiers":5074},"McKenzie, A. J. et al. KRAS–MEK signaling controls Ago2 sorting into exosomes. Cell Rep. 15, 978–987 (2016).",{"doi":5075},"10.1016\u002Fj.celrep.2016.03.085",{"id":28,"text":5077,"url":28,"identifiers":5078},"Teng, Y. et al. MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nat. Commun. 8, 14448 (2017).",{"doi":5079},"10.1038\u002Fncomms14448",{"id":28,"text":5081,"url":28,"identifiers":5082},"Shurtleff, M. J., Temoche-Diaz, M. M., Karfilis, K. V., Ri, S. & Schekman, R. Y-Box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction. eLife 5, e19276 (2016).",{"doi":5083},"10.7554\u002FeLife.19276",{"id":28,"text":5085,"url":28,"identifiers":5086},"Carayon, K. et al. Proteolipidic composition of exosomes changes during reticulocyte maturation. J. Biol. Chem. 286, 34426–34439 (2011).",{"doi":5087},"10.1074\u002Fjbc.M111.257444",{"id":28,"text":5089,"url":28,"identifiers":5090},"Segura, E., Amigorena, S. & Thery, C. Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol. Dis. 35, 89–93 (2005).",{"doi":5091},"10.1016\u002Fj.bcmd.2005.05.003",{"id":28,"text":5093,"url":28,"identifiers":5094},"Mobius, W. et al. Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O. J. Histochem. Cytochem. 50, 43–55 (2002).",{"doi":5095},"10.1177\u002F002215540205000105",{"id":28,"text":5097,"url":28,"identifiers":5098},"van Niel, G. et al. Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. Immunity 25, 885–894 (2006).",{"doi":5099},"10.1016\u002Fj.immuni.2006.11.001",{"id":28,"text":5101,"url":28,"identifiers":5102},"Edgar, J. R., Eden, E. R. & Futter, C. E. Hrs- and CD63-dependent competing mechanisms make different sized endosomal intraluminal vesicles. Traffic 15, 197–211 (2014).",{"doi":5103},"10.1111\u002Ftra.12139",{"id":28,"text":5105,"url":28,"identifiers":5106},"Hristov, M., Erl, W., Linder, S. & Weber, P. C. Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood 104, 2761–2766 (2004).",{"doi":5107},"10.1182\u002Fblood-2003-10-3614",{"id":28,"text":5109,"url":28,"identifiers":5110},"Piccin, A., Murphy, W. G. & Smith, O. P. Circulating microparticles: pathophysiology and clinical implications. Blood Rev. 21, 157–171 (2007).",{"doi":5111},"10.1016\u002Fj.blre.2006.09.001",{"id":28,"text":5113,"url":28,"identifiers":5114},"Jimenez, J. J. et al. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb. Res. 109, 175–180 (2003).",{"doi":5115},"10.1016\u002FS0049-3848(03)00064-1",{"id":28,"text":5117,"url":28,"identifiers":5118},"Connor, D. E., Exner, T., Ma, D. D. & Joseph, J. E. The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib. Thromb. Haemost. 103, 1044–1052 (2010).",{"doi":5119},"10.1160\u002FTH09-09-0644",{"id":28,"text":5121,"url":28,"identifiers":5122},"Del Conde, I., Shrimpton, C. N., Thiagarajan, P. & Lopez, J. A. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 106, 1604–1611 (2005).",{"doi":5123},"10.1182\u002Fblood-2004-03-1095",{"id":28,"text":5125,"url":28,"identifiers":5126},"Li, B., Antonyak, M. A., Zhang, J. & Cerione, R. A. RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene 31, 4740–4749 (2012).",{"doi":5127},"10.1038\u002Fonc.2011.636",{"id":28,"text":5129,"url":28,"identifiers":5130},"McConnell, R. E. et al. The enterocyte microvillus is a vesicle-generating organelle. J. Cell Biol. 185, 1285–1298 (2009).",{"doi":5131},"10.1083\u002Fjcb.200902147",{"id":28,"text":5133,"url":28,"identifiers":5134},"Warburg, O. On respiratory impairment in cancer cells. Science 124, 269–270 (1956).",{"doi":5135},"10.1126\u002Fscience.124.3215.269",{"id":28,"text":5137,"url":28,"identifiers":5138},"Wilson, K. F., Erickson, J. W., Antonyak, M. A. & Cerione, R. A. Rho GTPases and their roles in cancer metabolism. Trends Mol. Med. 19, 74–82 (2013).",{"doi":5139},"10.1016\u002Fj.molmed.2012.10.011",{"id":28,"text":5141,"url":28,"identifiers":5142},"Shen, B., Fang, Y., Wu, N. & Gould, S. J. Biogenesis of the posterior pole is mediated by the exosome\u002Fmicrovesicle protein-sorting pathway. J. Biol. Chem. 286, 44162–44176 (2011).",{"doi":5143},"10.1074\u002Fjbc.M111.274803",{"id":28,"text":5145,"url":28,"identifiers":5146},"Yang, J. M. & Gould, S. J. The cis-acting signals that target proteins to exosomes and microvesicles. Biochem. Soc. Trans. 41, 277–282 (2013).",{"doi":5147},"10.1042\u002FBST20120275",{"id":28,"text":5149,"url":28,"identifiers":5150},"Bolukbasi, M. F. et al. miR-1289 and “zipcode”-like sequence enrich mRNAs in microvesicles. Mol. Ther. Nucleic Acids 1, e10 (2012).",{"doi":5151},"10.1038\u002Fmtna.2011.2",{"id":28,"text":5153,"url":28,"identifiers":5154},"Mittelbrunn, M., Vicente-Manzanares, M. & Sanchez-Madrid, F. Organizing polarized delivery of exosomes at synapses. Traffic 16, 327–337 (2015).",{"doi":5155},"10.1111\u002Ftra.12258",{"id":28,"text":5157,"url":28,"identifiers":5158},"Eitan, E., Suire, C., Zhang, S. & Mattson, M. P. Impact of lysosome status on extracellular vesicle content and release. Ageing Res. Rev. 32, 65–74 (2016).",{"doi":5159},"10.1016\u002Fj.arr.2016.05.001",{"id":28,"text":5161,"url":28,"identifiers":5162},"Alvarez-Erviti, L. et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29, 341–345 (2011).",{"doi":5163},"10.1038\u002Fnbt.1807",{"id":28,"text":5165,"url":28,"identifiers":5166},"Villarroya-Beltri, C. et al. ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins. Nat. Commun. 7, 13588 (2016).",{"doi":5167},"10.1038\u002Fncomms13588",{"id":28,"text":5169,"url":28,"identifiers":5170},"Edgar, J. R., Manna, P. T., Nishimura, S., Banting, G. & Robinson, M. S. Tetherin is an exosomal tether. eLife 5, e17180 (2016). This study shows that exosomes can be released as clusters that remain attached to each other and anchored to the cell surface by tetherin. It suggests that the tetherin-mediated attachment may have a key role in exosome fate.",{"doi":5171},"10.7554\u002FeLife.17180",{"id":28,"text":5173,"url":28,"identifiers":5174},"Liegeois, S., Benedetto, A., Garnier, J. M., Schwab, Y. & Labouesse, M. The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. J. Cell Biol. 173, 949–961 (2006).",{"doi":5175},"10.1083\u002Fjcb.200511072",{"id":28,"text":5177,"url":28,"identifiers":5178},"Guix, F. X. et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Mol. Neurodegener. 12, 25 (2017).",{"doi":5179},"10.1186\u002Fs13024-017-0165-0",{"id":28,"text":5181,"url":28,"identifiers":5182},"van Niel, G., Porto-Carreiro, I., Simoes, S. & Raposo, G. Exosomes: a common pathway for a specialized function. J. Biochem. 140, 13–21 (2006).",{"doi":5183},"10.1093\u002Fjb\u002Fmvj128",{"id":28,"text":5185,"url":28,"identifiers":5186},"Papandreou, M. E. & Tavernarakis, N. Autophagy and the endo\u002Fexosomal pathways in health and disease. Biotechnol. J. 12, 1600175 (2017).",{"doi":5187},"10.1002\u002Fbiot.201600175",{"id":28,"text":5189,"url":28,"identifiers":5190},"Dias, M. V. et al. PRNP\u002Fprion protein regulates the secretion of exosomes modulating CAV1\u002Fcaveolin-1-suppressed autophagy. Autophagy 12, 2113–2128 (2016).",{"doi":5191},"10.1080\u002F15548627.2016.1226735",{"id":28,"text":5193,"url":28,"identifiers":5194},"Hessvik, N. P. et al. PIKfyve inhibition increases exosome release and induces secretory autophagy. Cell. Mol. Life Sci. 73, 4717–4737 (2016).",{"doi":5195},"10.1007\u002Fs00018-016-2309-8",{"id":28,"text":5197,"url":28,"identifiers":5198},"Bonifacino, J. S. & Glick, B. S. The mechanisms of vesicle budding and fusion. Cell 116, 153–166 (2004).",{"doi":5199},"10.1016\u002FS0092-8674(03)01079-1",{"id":28,"text":5201,"url":28,"identifiers":5202},"Cai, H., Reinisch, K. & Ferro-Novick, S. Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev.≈Cell 12, 671–682 (2007).",{"doi":5203},"10.1016\u002Fj.devcel.2007.04.005",{"id":28,"text":5205,"url":28,"identifiers":5206},"Mittelbrunn, M. et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat. Commun. 2, 282 (2011).",{"doi":5207},"10.1038\u002Fncomms1285",{"id":28,"text":5209,"url":28,"identifiers":5210},"Rocha, N. et al. Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. J. Cell Biol. 185, 1209–1225 (2009).",{"doi":5211},"10.1083\u002Fjcb.200811005",{"id":28,"text":5213,"url":28,"identifiers":5214},"Song, P., Trajkovic, K., Tsunemi, T. & Krainc, D. Parkin modulates endosomal organization and function of the endo-lysosomal pathway. J. Neurosci. 36, 2425–2437 (2016).",{"doi":5215},"10.1523\u002FJNEUROSCI.2569-15.2016",{"id":28,"text":5217,"url":28,"identifiers":5218},"Mobius, W. et al. Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway. Traffic 4, 222–231 (2003).",{"doi":5219},"10.1034\u002Fj.1600-0854.2003.00072.x",{"id":28,"text":5221,"url":28,"identifiers":5222},"Sinha, S. et al. Cortactin promotes exosome secretion by controlling branched actin dynamics. J. Cell Biol. 214, 197–213 (2016).",{"doi":5223},"10.1083\u002Fjcb.201601025",{"id":28,"text":5225,"url":28,"identifiers":5226},"Marks, M. S., Heijnen, H. F. & Raposo, G. Lysosome-related organelles: unusual compartments become mainstream. Curr. Opin. Cell Biol. 25, 495–505 (2013).",{"doi":5227},"10.1016\u002Fj.ceb.2013.04.008",{"id":28,"text":5229,"url":28,"identifiers":5230},"Hsu, C. et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J. Cell Biol. 189, 223–232 (2010).",{"doi":5231},"10.1083\u002Fjcb.200911018",{"id":28,"text":5233,"url":28,"identifiers":5234},"Savina, A., Furlan, M., Vidal, M. & Colombo, M. I. Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J. Biol. Chem. 278, 20083–20090 (2003).",{"doi":5235},"10.1074\u002Fjbc.M301642200",{"id":28,"text":5237,"url":28,"identifiers":5238},"Jahn, R. & Scheller, R. H. SNAREs—engines for membrane fusion. Nat. Rev. Mol. Cell Biol. 7, 631–643 (2006).",{"doi":5239},"10.1038\u002Fnrm2002",{"id":28,"text":5241,"url":28,"identifiers":5242},"Rao, J. & Fitzpatrick, R. E. Use of the Q-switched 755-nm alexandrite laser to treat recalcitrant pigment after depigmentation therapy for vitiligo. Dermatol. Surg. 30, 1043–1045 (2004).",{},{"id":28,"text":5244,"url":28,"identifiers":5245},"Fader, C. M., Sánchez, D. G., Mestre, M. B. & Colombo, M. I. TI-VAMP\u002FVAMP7 and VAMP3\u002Fcellubrevin: two v-SNARE proteins involved in specific steps of the autophagy\u002Fmultivesicular body pathways. Biochim. Biophys. Acta 1793, 1901–1916 (2009).",{"doi":5246},"10.1016\u002Fj.bbamcr.2009.09.011",{"id":28,"text":5248,"url":28,"identifiers":5249},"Proux-Gillardeaux, V., Raposo, G., Irinopoulou, T. & Galli, T. Expression of the Longin domain of TI-VAMP impairs lysosomal secretion and epithelial cell migration. Biol. Cell 99, 261–271 (2007).",{"doi":5250},"10.1042\u002FBC20060097",{"id":28,"text":5252,"url":28,"identifiers":5253},"Faure, J. et al. Exosomes are released by cultured cortical neurones. Mol. Cell Neurosci. 31, 642–648 (2006).",{"doi":5254},"10.1016\u002Fj.mcn.2005.12.003",{"id":28,"text":5256,"url":28,"identifiers":5257},"Raposo, G. et al. Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol. Biol. Cell 8, 2631–2645 (1997).",{"doi":5258},"10.1091\u002Fmbc.8.12.2631",{"id":28,"text":5260,"url":28,"identifiers":5261},"Savina, A., Fader, C. M., Damiani, M. T. & Colombo, M. I. Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner. Traffic 6, 131–143 (2005).",{"doi":5262},"10.1111\u002Fj.1600-0854.2004.00257.x",{"id":28,"text":5264,"url":28,"identifiers":5265},"Puri, N. & Roche, P. A. Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms. Proc. Natl Acad. Sci. USA 105, 2580–2585 (2008).",{"doi":5266},"10.1073\u002Fpnas.0707854105",{"id":28,"text":5268,"url":28,"identifiers":5269},"Wei, Y. et al. Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23. Nat. Commun. 8, 14041 (2017).",{"doi":5270},"10.1038\u002Fncomms14041",{"id":28,"text":5272,"url":28,"identifiers":5273},"Gross, J. C., Chaudhary, V., Bartscherer, K. & Boutros, M. Active Wnt proteins are secreted on exosomes. Nat. Cell Biol. 14, 1036–1045 (2012).",{"doi":5274},"10.1038\u002Fncb2574",{"id":28,"text":5276,"url":28,"identifiers":5277},"Hyenne, V. et al. RAL-1 controls multivesicular body biogenesis and exosome secretion. J. Cell Biol. 211, 27–37 (2015).",{"doi":5278},"10.1083\u002Fjcb.201504136",{"id":28,"text":5280,"url":28,"identifiers":5281},"Koles, K. & Budnik, V. Exosomes go with the Wnt. Cell Logist 2, 169–173 (2012).",{"doi":5282},"10.4161\u002Fcl.21981",{"id":28,"text":5284,"url":28,"identifiers":5285},"Matsumoto, A. et al. Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells. Cancer Sci. 108, 1803–1810 (2017).",{"doi":5286},"10.1111\u002Fcas.13310",{"id":28,"text":5288,"url":28,"identifiers":5289},"D'Souza-Schorey, C. & Clancy, J. W. Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev. 26, 1287–1299 (2012).",{"doi":5290},"10.1101\u002Fgad.192351.112",{"id":28,"text":5292,"url":28,"identifiers":5293},"Sedgwick, A. E., Clancy, J. W., Olivia Balmert, M. & D'Souza-Schorey, C. Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion. Sci. Rep. 5, 14748 (2015).",{"doi":5294},"10.1038\u002Fsrep14748",{"id":28,"text":5296,"url":28,"identifiers":5297},"Schlienger, S., Campbell, S. & Claing, A. ARF1 regulates the Rho\u002FMLC pathway to control EGF-dependent breast cancer cell invasion. Mol. Biol. Cell 25, 17–29 (2014).",{"doi":5298},"10.1091\u002Fmbc.e13-06-0335",{"id":28,"text":5300,"url":28,"identifiers":5301},"Wehman, A. M., Poggioli, C., Schweinsberg, P., Grant, B. D. & Nance, J. The P4-ATPase TAT-5 inhibits the budding of extracellular vesicles in C. elegans embryos. Curr. Biol. 21, 1951–1959 (2011).",{"doi":5302},"10.1016\u002Fj.cub.2011.10.040",{"id":28,"text":5304,"url":28,"identifiers":5305},"Taverna, S. et al. Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells. J. Biol. Chem. 278, 51911–51919 (2003).",{"doi":5306},"10.1074\u002Fjbc.M304192200",{"id":28,"text":5308,"url":28,"identifiers":5309},"Cocucci, E., Racchetti, G. & Meldolesi, J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 19, 43–51 (2009).",{"doi":5310},"10.1016\u002Fj.tcb.2008.11.003",{"id":28,"text":5312,"url":28,"identifiers":5313},"Bianco, F. et al. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J. Immunol. 174, 7268–7277 (2005).",{"doi":5314},"10.4049\u002Fjimmunol.174.11.7268",{"id":28,"text":5316,"url":28,"identifiers":5317},"Thomas, L. M. & Salter, R. D. Activation of macrophages by P2X7-induced microvesicles from myeloid cells is mediated by phospholipids and is partially dependent on TLR4. J. Immunol. 185, 3740–3749 (2010).",{"doi":5318},"10.4049\u002Fjimmunol.1001231",{"id":28,"text":5320,"url":28,"identifiers":5321},"Bianco, F. et al. Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J. 28, 1043–1054 (2009).",{"doi":5322},"10.1038\u002Femboj.2009.45",{"id":28,"text":5324,"url":28,"identifiers":5325},"Mulcahy, L. A., Pink, R. C. & Carter, D. R. Routes and mechanisms of extracellular vesicle uptake. J. Extracell. Vesicles 3, 24641 (2014).",{"doi":5326},"10.3402\u002Fjev.v3.24641",{"id":28,"text":5328,"url":28,"identifiers":5329},"Denzer, K. et al. Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J. Immunol. 165, 1259–1265 (2000).",{"doi":5330},"10.4049\u002Fjimmunol.165.3.1259",{"id":28,"text":5332,"url":28,"identifiers":5333},"Mallegol, J. et al. T84-intestinal epithelial exosomes bear MHC class II\u002Fpeptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology 132, 1866–1876 (2007).",{"doi":5334},"10.1053\u002Fj.gastro.2007.02.043",{"id":28,"text":5336,"url":28,"identifiers":5337},"Nolte-'t Hoen, E. N., Buschow, S. I., Anderton, S. M., Stoorvogel, W. & Wauben, M. H. Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood 113, 1977–1981 (2009).",{"doi":5338},"10.1182\u002Fblood-2008-08-174094",{"id":28,"text":5340,"url":28,"identifiers":5341},"Chivet, M. et al. Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons. J. Extracell. Vesicles 3, 24722 (2014).",{"doi":5342},"10.3402\u002Fjev.v3.24722",{"id":28,"text":5344,"url":28,"identifiers":5345},"Hoshino, A. et al. Tumour exosome integrins determine organotropic metastasis. Nature 527, 329–335 (2015). This study shows for the first time that exosomal integrins have a key role in directing exosomes from cancer cells to particular organs and that this transfer induces metastasis.",{"doi":5346},"10.1038\u002Fnature15756",{"id":28,"text":5348,"url":28,"identifiers":5349},"Morelli, A. E. et al. Endocytosis, intracellular sorting and processing of exosomes by dendritic cells. Blood 104, 3257–3266 (2004).",{"doi":5350},"10.1182\u002Fblood-2004-03-0824",{"id":28,"text":5352,"url":28,"identifiers":5353},"Sung, B. H., Ketova, T., Hoshino, D., Zijlstra, A. & Weaver, A. M. Directional cell movement through tissues is controlled by exosome secretion. Nat. Commun. 6, 7164 (2015).",{"doi":5354},"10.1038\u002Fncomms8164",{"id":28,"text":5356,"url":28,"identifiers":5357},"Purushothaman, A. et al. Fibronectin on the surface of myeloma cell-derived exosomes mediates exosome-cell interactions. J. Biol. Chem. 291, 1652–1663 (2016).",{"doi":5358},"10.1074\u002Fjbc.M115.686295",{"id":28,"text":5360,"url":28,"identifiers":5361},"Leiss, M., Beckmann, K., Giros, A., Costell, M. & Fassler, R. The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr. Opin. Cell Biol. 20, 502–507 (2008).",{"doi":5362},"10.1016\u002Fj.ceb.2008.06.001",{"id":28,"text":5364,"url":28,"identifiers":5365},"Rana, S., Yue, S., Stadel, D. & Zoller, M. Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection. Int. J. Biochem. Cell Biol. 44, 1574–1584 (2012).",{"doi":5366},"10.1016\u002Fj.biocel.2012.06.018",{"id":28,"text":5368,"url":28,"identifiers":5369},"Nazarenko, I. et al. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 70, 1668–1678 (2010).",{"doi":5370},"10.1158\u002F0008-5472.CAN-09-2470",{"id":28,"text":5372,"url":28,"identifiers":5373},"Rana, S., Claas, C., Kretz, C. C., Nazarenko, I. & Zoeller, M. Activation-induced internalization differs for the tetraspanins CD9 and Tspan8: Impact on tumor cell motility. Int. J. Biochem. Cell Biol. 43, 106–119 (2011).",{"doi":5374},"10.1016\u002Fj.biocel.2010.10.002",{"id":28,"text":5376,"url":28,"identifiers":5377},"Melo, S. A. et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523, 177–182 (2015).",{"doi":5378},"10.1038\u002Fnature14581",{"id":28,"text":5380,"url":28,"identifiers":5381},"Bruno, S. et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J. Am. Soc. Nephrol. 20, 1053–1067 (2009).",{"doi":5382},"10.1681\u002FASN.2008070798",{"id":28,"text":5384,"url":28,"identifiers":5385},"Barres, C. et al. Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages. Blood 115, 696–705 (2010).",{"doi":5386},"10.1182\u002Fblood-2009-07-231449",{"id":28,"text":5388,"url":28,"identifiers":5389},"Frey, B. & Gaipl, U. S. The immune functions of phosphatidylserine in membranes of dying cells and microvesicles. Semin. Immunopathol. 33, 497–516 (2011).",{"doi":5390},"10.1007\u002Fs00281-010-0228-6",{"id":28,"text":5392,"url":28,"identifiers":5393},"Feng, D. et al. Cellular internalization of exosomes occurs through phagocytosis. Traffic 11, 675–687 (2010).",{"doi":5394},"10.1111\u002Fj.1600-0854.2010.01041.x",{"id":28,"text":5396,"url":28,"identifiers":5397},"Nakase, I., Kobayashi, N. B., Takatani-Nakase, T. & Yoshida, T. Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes. Sci. Rep. 5, 10300 (2015).",{"doi":5398},"10.1038\u002Fsrep10300",{"id":28,"text":5400,"url":28,"identifiers":5401},"Tian, T. et al. Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery. J. Biol. Chem. 289, 22258–22267 (2014).",{"doi":5402},"10.1074\u002Fjbc.M114.588046",{"id":28,"text":5404,"url":28,"identifiers":5405},"Laulagnier, K. et al. Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons. Cell. Mol. Life Sci. http:\u002F\u002Fdx.doi.org\u002F10.1007\u002Fs00018-017-2664-0 (2017).",{"doi":5406},"10.1007\u002Fs00018-017-2664-0",{"id":28,"text":5408,"url":28,"identifiers":5409},"Vargas, A. et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB J. 28, 3703–3719 (2014).",{"doi":5410},"10.1096\u002Ffj.13-239053",{"id":28,"text":5412,"url":28,"identifiers":5413},"Kamerkar, S. et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature 546, 498–503 (2017).",{"doi":5414},"10.1038\u002Fnature22341",{"id":28,"text":5416,"url":28,"identifiers":5417},"Prada, I. et al. A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers. Biotechniques 60, 35–41 (2016).",{"doi":5418},"10.2144\u002F000114371",{"id":28,"text":5420,"url":28,"identifiers":5421},"Heusermann, W. et al. Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER. J. Cell Biol. 213, 173–184 (2016).",{"doi":5422},"10.1083\u002Fjcb.201506084",{"id":28,"text":5424,"url":28,"identifiers":5425},"Escrevente, C., Keller, S., Altevogt, P. & Costa, J. Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer 11, 108 (2011).",{"doi":5426},"10.1186\u002F1471-2407-11-108",{"id":28,"text":5428,"url":28,"identifiers":5429},"Chen, W. et al. Nanoscale characterization of carrier dynamic and surface passivation in InGaN\u002FGaN multiple quantum wells on GaN nanorods. ACS Appl. Mater. Interfaces 8, 31887–31893 (2016).",{"doi":5430},"10.1021\u002Facsami.6b11675",{"id":28,"text":5432,"url":28,"identifiers":5433},"Tian, T., Wang, Y., Wang, H., Zhu, Z. & Xiao, Z. Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy. J. Cell. Biochem. 111, 488–496 (2010).",{"doi":5434},"10.1002\u002Fjcb.22733",{"id":28,"text":5436,"url":28,"identifiers":5437},"Bissig, C. & Gruenberg, J. ALIX and the multivesicular endosome: ALIX in Wonderland. Trends Cell Biol. 24, 19–25 (2014).",{"doi":5438},"10.1016\u002Fj.tcb.2013.10.009",{"id":28,"text":5440,"url":28,"identifiers":5441},"Antonyak, M. A. et al. Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc. Natl Acad. Sci. USA 108, 4852–4857 (2011).",{"doi":5442},"10.1073\u002Fpnas.1017667108",{"id":28,"text":5444,"url":28,"identifiers":5445},"Desrochers, L. M., Bordeleau, F., Reinhart-King, C. A., Cerione, R. A. & Antonyak, M. A. Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation. Nat. Commun. 7, 11958 (2016).",{"doi":5446},"10.1038\u002Fncomms11958",{"id":28,"text":5448,"url":28,"identifiers":5449},"Zhang, L. & Wrana, J. L. The emerging role of exosomes in Wnt secretion and transport. Curr. Opin. Genet. Dev. 27, 14–19 (2014).",{"doi":5450},"10.1016\u002Fj.gde.2014.03.006",{"id":28,"text":5452,"url":28,"identifiers":5453},"Skog, J. et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470–1476 (2008).",{"doi":5454},"10.1038\u002Fncb1800",{"id":28,"text":5456,"url":28,"identifiers":5457},"Record, M., Carayon, K., Poirot, M. & Silvente-Poirot, S. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim. Biophys. Acta 1841, 108–120 (2014).",{"doi":5458},"10.1016\u002Fj.bbalip.2013.10.004",{"id":28,"text":5460,"url":28,"identifiers":5461},"Coleman, B. M. & Hill, A. F. Extracellular vesicles—their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases. Semin. Cell Dev. Biol. 40, 89–96 (2015).",{"doi":5462},"10.1016\u002Fj.semcdb.2015.02.007",{"id":28,"text":5464,"url":28,"identifiers":5465},"van Dongen, H. M., Masoumi, N., Witwer, K. W. & Pegtel, D. M. Extracellular vesicles exploit viral entry routes for cargo delivery. Microbiol. Mol. Biol. Rev. 80, 369–386 (2016).",{"doi":5466},"10.1128\u002FMMBR.00063-15",{"id":28,"text":5468,"url":28,"identifiers":5469},"Zhao, H. et al. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. eLife 5, e10250 (2016).",{"doi":5470},"10.7554\u002FeLife.10250",{"id":28,"text":5472,"url":28,"identifiers":5473},"Peinado, H. et al. Pre-metastatic niches: organ-specific homes for metastases. Nat. Rev. Cancer 17, 302–317 (2017).",{"doi":5474},"10.1038\u002Fnrc.2017.6",{"id":28,"text":5476,"url":28,"identifiers":5477},"Fais, S. et al. Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine. ACS Nano 10, 3886–3899 (2016).",{"doi":5478},"10.1021\u002Facsnano.5b08015",{"id":28,"text":5480,"url":28,"identifiers":5481},"Dinkins, M. B., Dasgupta, S., Wang, G., Zhu, G. & Bieberich, E. Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease. Neurobiol. Aging 35, 1792–1800 (2014).",{"doi":5482},"10.1016\u002Fj.neurobiolaging.2014.02.012",{"id":28,"text":5484,"url":28,"identifiers":5485},"Torrano, V. et al. Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer. Curr. Opin. Pharmacol. 29, 47–53 (2016).",{"doi":5486},"10.1016\u002Fj.coph.2016.06.003",{"id":28,"text":5488,"url":28,"identifiers":5489},"El Andaloussi, S., Lakhal, S., Mager, I. & Wood, M. J. Exosomes for targeted siRNA delivery across biological barriers. Adv. Drug Deliv. Rev. 65, 391–397 (2013).",{"doi":5490},"10.1016\u002Fj.addr.2012.08.008",{"id":28,"text":5492,"url":28,"identifiers":5493},"Pitt, J. M. et al. Dendritic cell-derived exosomes as immunotherapies in the fight against cancer. J. Immunol. 193, 1006–1011 (2014).",{"doi":5494},"10.4049\u002Fjimmunol.1400703",{"id":28,"text":5496,"url":28,"identifiers":5497},"Besse, B. et al. Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. Oncoimmunology 5, e1071008 (2016).",{"doi":5498},"10.1080\u002F2162402X.2015.1071008",{"id":28,"text":5500,"url":28,"identifiers":5501},"Lener, T. et al. Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. J. Extracell. Vesicles 4, 30087 (2015).",{"doi":5502},"10.3402\u002Fjev.v4.30087",{"id":28,"text":5504,"url":28,"identifiers":5505},"Lo Cicero, A. et al. Exosomes released by keratinocytes modulate melanocyte pigmentation. Nat. Commun. 6, 7506 (2015).",{"doi":5506},"10.1038\u002Fncomms8506",{"id":28,"text":5508,"url":28,"identifiers":5509},"Beauvillain, C., Juste, M. O., Dion, S., Pierre, J. & Dimier-Poisson, I. Exosomes are an effective vaccine against congenital toxoplasmosis in mice. Vaccine 27, 1750–1757 (2009).",{"doi":5510},"10.1016\u002Fj.vaccine.2009.01.022",{"id":28,"text":5512,"url":28,"identifiers":5513},"Ranghino, A. et al. The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury. Stem Cell Res. Ther. 8, 24 (2017).",{"doi":5514},"10.1186\u002Fs13287-017-0478-5",{"id":28,"text":5516,"url":28,"identifiers":5517},"Arslan, F. et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K\u002FAkt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia\u002Freperfusion injury. Stem Cell Res. 10, 301–312 (2013).",{"doi":5518},"10.1016\u002Fj.scr.2013.01.002",{"id":28,"text":5520,"url":28,"identifiers":5521},"Ophelders, D. R. et al. Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia. Stem Cells Transl Med. 5, 754–763 (2016).",{"doi":5522},"10.5966\u002Fsctm.2015-0197",{"id":28,"text":5524,"url":28,"identifiers":5525},"Mizrak, A. et al. Genetically engineered microvesicles carrying suicide mRNA\u002Fprotein inhibit schwannoma tumor growth. Mol. Ther. 21, 101–108 (2013).",{"doi":5526},"10.1038\u002Fmt.2012.161",{"id":28,"text":5528,"url":28,"identifiers":5529},"Pan, S., Yang, X., Jia, Y., Li, R. & Zhao, R. Microvesicle-shuttled miR-130b reduces fat deposition n recipient primary cultured porcine adipocytes by inhibiting PPAR-g expression. J. Cell. Physiol. 229, 631–639 (2014).",{"doi":5530},"10.1002\u002Fjcp.24486",{"id":28,"text":5532,"url":28,"identifiers":5533},"Coumans, F. A. W. et al. Methodological guidelines to study extracellular vesicles. Circ. Res. 120, 1632–1648 (2017).",{"doi":5534},"10.1161\u002FCIRCRESAHA.117.309417",{"id":28,"text":5536,"url":28,"identifiers":5537},"Van Deun, J. et al. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat. Methods 14, 228–232 (2017).",{"doi":5538},"10.1038\u002Fnmeth.4185",{"id":28,"text":5540,"url":28,"identifiers":5541},"Takov, K., Yellon, D. M. & Davidson, S. M. Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes. J. Extracell. Vesicles 6, 1388731 (2017).",{"doi":5542},"10.1080\u002F20013078.2017.1388731",{"id":28,"text":5544,"url":28,"identifiers":5545},"Hyenne, V., Lefebvre, O. & Goetz, J. G. Going live with tumor exosomes and microvesicles. Cell Adh. Migr. 11, 173–186 (2017).",{"doi":5546},"10.1080\u002F19336918.2016.1276694",{"id":28,"text":5548,"url":28,"identifiers":5549},"Lai, C. P., Tannous, B. A. & Breakefield, X. O. Noninvasive in vivo monitoring of extracellular vesicles. Methods Mol. Biol. 1098, 249–258 (2014).",{"doi":5550},"10.1007\u002F978-1-62703-718-1_19",{"id":28,"text":5552,"url":28,"identifiers":5553},"Zomer, A. et al. In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior. Cell 161, 1046–1057 (2015). This study uses in vivo imaging to reveal the existence of a functional transfer of mRNA mediated by extracellular vesicles in the context of cancer and metastasis.",{"doi":5554},"10.1016\u002Fj.cell.2015.04.042",{"id":28,"text":5556,"url":28,"identifiers":5557},"Bobrie, A., Colombo, M., Krumeich, S., Raposo, G. & Thery, C. Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation. J. Extracell. Vesicles 1, 18397 (2012).",{"doi":5558},"10.3402\u002Fjev.v1i0.18397",{"id":28,"text":5560,"url":28,"identifiers":5561},"Roucourt, B., Meeussen, S., Bao, J., Zimmermann, P. & David, G. Heparanase activates the syndecan-syntenin-ALIX exosome pathway. Cell Res. 25, 412–428 (2015).",{"doi":5562},"10.1038\u002Fcr.2015.29",{"id":28,"text":5564,"url":28,"identifiers":5565},"van Niel, G. et al. Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121, 337–349 (2001).",{"doi":5566},"10.1053\u002Fgast.2001.26263",{"id":28,"text":5568,"url":28,"identifiers":5569},"Tauro, B. J. et al. Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. Mol. Cell. Proteomics 12, 587–598 (2013).",{"doi":5570},"10.1074\u002Fmcp.M112.021303",{"id":5572,"createTime":5573,"updateTime":5573,"relativeEntities":5574,"slug":5575,"properties":5576,"entityType":971,"verifyStatus":26,"verifyTime":5573,"verifyNote":972,"languages":5587,"translateLanguages":28,"viewCount":32,"primaryUrl":5588,"fullTextUrl":28,"authors":5589,"publicationType":1063,"publisherRelationship":5641,"citationCount":5694,"citationInfo":5695,"publishDate":3724,"publishYear":3714,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":5706,"openAccess":28,"references":5707,"isForceReanalyzing":1713},"b0353bcb-8974-4c81-b5b6-61f1f75bdc1d","2024-09-28T04:50:09.698+00:00",[],"The-versatility-and-universality-of-calcium-signalling",{"openalex":5577,"mag":5579,"title":5581,"pm":5583,"doi":5585},{"VOID":5578},"W1599277155",{"VOID":5580},"1599277155",{"EN":5582},"The versatility and universality of calcium signalling",{"VOID":5584},"11413485",{"VOID":5586},"10.1038\u002F35036035",[31],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002F35036035",[5590,5607,5624],{"id":5591,"sortIndex":32,"researcher":28,"roles":5592,"affiliations":5593,"properties":5602,"displayName":5604,"givenName":28,"familyName":28},"3aa3d365-0a59-4bee-852d-4d1189f36807",[],[5594],{"id":5595,"sortIndex":32,"affiliation":5596,"properties":28},"5c39be10-5f87-4f96-b006-6148c901d8b9",{"id":5595,"createTime":28,"updateTime":28,"relativeEntities":5597,"slug":28,"properties":5598,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":5601,"statistic":28},[],{"title":5599},{"EN":5600},"The Babraham Institute, Laboratory of Molecular Signalling, Babraham Hall, Babraham, UK",[],{"title":5603,"openalex":5605},{"EN":5604},"Michael J. 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J. Inositol trisphosphate and calcium signalling. Nature 361, 315?325 (1993).",{"doi":5711},"10.1038\u002F361315a0",{"id":28,"text":5713,"url":28,"identifiers":5714},"Clapham, D. E. Calcium signaling. Cell 80, 259? 268 (1995).",{"doi":5715},"10.1016\u002F0092-8674(95)90408-5",{"id":28,"text":5717,"url":28,"identifiers":5718},"Clapper, D. L., Walseth, T. F., Dargei, P. J. & Lee, H. C. Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate. J. Biol. Chem. 262, 9561?9568 ( 1987).",{"doi":5719},"10.1016\u002FS0021-9258(18)47970-7",{"id":28,"text":5721,"url":28,"identifiers":5722},"Genazzini, A. A. & Galione, A. A. Ca2+ release mechanism gated by the novel pyridine nucleotide, NAADP. Trends Pharmacol. Sci. 18, 108?110 (1997).",{"doi":5723},"10.1016\u002FS0165-6147(96)01036-X",{"id":28,"text":5725,"url":28,"identifiers":5726},"Mao, C. G. et al. Molecular cloning and characterization of SCaMPER, a sphingolipid Ca2+ release-mediating protein from endoplasmic reticulum. Proc. Natl Acad. Sci. USA 93, 1993? 1996 (1996).",{"doi":5727},"10.1073\u002Fpnas.93.5.1993",{"id":28,"text":5729,"url":28,"identifiers":5730},"Cancela, J. M. & Petersen, O. H. The cyclic ADP ribose antagonist 8-NH2-cADP-ribose blocks cholecystokinin-evoked cytosolic Ca2+ spiking in pancreatic acinar cells. Pfluger's Arch. 435, 746?748 (1998).",{"doi":5731},"10.1007\u002Fs004240050578",{"id":28,"text":5733,"url":28,"identifiers":5734},"Young, K. W., Challiss, R. A. J., Nahorski, S. R., & Mackrill, J. J. Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation. Biochem. J. 343, 45?52 (1999).",{"doi":5735},"10.1042\u002Fbj3430045",{"id":28,"text":5737,"url":28,"identifiers":5738},"Putney, J. W. Jr. A model for receptor-regulated calcium entry. Cell Calcium 7, 1?12 ( 1986).",{"doi":5739},"10.1016\u002F0143-4160(86)90026-6",{"id":28,"text":5741,"url":28,"identifiers":5742},"Hofmann, T. et al. Direct activation of human TRP6 and TRPC3 channels by diacylglycerol . Nature 397, 259?263 (1999).The mammalian homologues of the Drosophila transient receptor potential (TRP) proteins function as Ca2+ channels but their control is still largely unknown. This paper suggests that some may be regulated by diacylglycerol.",{"doi":5743},"10.1038\u002F16711",{"id":28,"text":5745,"url":28,"identifiers":5746},"Broad, L. M., Cannon, T. R. & Taylor, C. W. A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin. J. Physiol. 517, 121?134 ( 1999).",{"doi":5747},"10.1111\u002Fj.1469-7793.1999.0121z.x",{"id":28,"text":5749,"url":28,"identifiers":5750},"Mignen, O. & Shuttleworth, T. J. IARC, a novel arachidonate-regulated, noncapacitative Ca2+ entry channel . J. Biol. Chem. 275, 9114? 9119 (2000).",{"doi":5751},"10.1074\u002Fjbc.275.13.9114",{"id":28,"text":5753,"url":28,"identifiers":5754},"Kiselyov, K. et al. Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature 396, 478?482 (1998).Some of the first evidence to indicate that inositol-1,4,5-trisphosphate receptors might be directly linked to Ca2+ channels in the plasma membrane.",{"doi":5755},"10.1038\u002F24890",{"id":28,"text":5757,"url":28,"identifiers":5758},"Boulay, G. et al. Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry. Proc. Natl Acad. Sci. USA 96, 14955?14960 (1999).",{"doi":5759},"10.1073\u002Fpnas.96.26.14955",{"id":28,"text":5761,"url":28,"identifiers":5762},"Berridge, M. J. Capacitative calcium entry. Biochem. J. 312, 1?11 (1995).",{"doi":5763},"10.1042\u002Fbj3120001",{"id":28,"text":5765,"url":28,"identifiers":5766},"Bootman, M. D. & Lipp, P. Calcium signalling: Ringing changes to the ?bell-shaped curve?. Curr. Biol. 9, R876?R878 ( 1999).",{"doi":5767},"10.1016\u002FS0960-9822(00)80072-X",{"id":28,"text":5769,"url":28,"identifiers":5770},"Mermelstein, P. G., Bito, H., Deisseroth, K. & Tsien, R. W. Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels support a selective response to EPSPs in preference to action potentials . J. Neurosci. 20, 266? 273 (2000).",{"doi":5771},"10.1523\u002FJNEUROSCI.20-01-00266.2000",{"id":28,"text":5773,"url":28,"identifiers":5774},"Berridge, M. J. Neuronal calcium signaling. Neuron 21, 13?26 (1998).",{"doi":5775},"10.1016\u002FS0896-6273(00)80510-3",{"id":28,"text":5777,"url":28,"identifiers":5778},"Nakamura, T., Barbara, J. G., Nakamura, K. & Ross, W. N. Synergistic release of Ca2+ from IP3-sensitive stores evoked by synaptic activation of mGluRs paired with backpropagating action potentials. Neuron 24, 727? 737 (1999).Direct evidence that the inositol-1,4,5-trisphosphate receptor may act as a coincident detector, integrating a Ca2+ signal coming from an action potential and inositol-1,4,5-trisphosphate generated by a metabotropic receptor.",{"doi":5779},"10.1016\u002FS0896-6273(00)81125-3",{"id":28,"text":5781,"url":28,"identifiers":5782},"Cancela, J. M., Churchill, G. C. & Galione, A. Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells. Nature 398, 74?76 (1999).",{"doi":5783},"10.1038\u002F18032",{"id":28,"text":5785,"url":28,"identifiers":5786},"Fierro, L. & Llano, I. High endogenous calcium buffering in Purkinje cells from rat cerebellar slices. J. Physiol. 496, 617?625 (1996).",{"doi":5787},"10.1113\u002Fjphysiol.1996.sp021713",{"id":28,"text":5789,"url":28,"identifiers":5790},"Pozzan, T., Rizzuto, R., Volpe, P. & Meldolesi, J. Molecular and cellular physiology of intracellular calcium stores. Physiol. Rev. 74, 595?636 ( 1994).",{"doi":5791},"10.1152\u002Fphysrev.1994.74.3.595",{"id":28,"text":5793,"url":28,"identifiers":5794},"Blaustein, M. P. & Lederer, W. J. Sodium\u002Fcalcium exchange: Its physiological implications. Physiol. Rev. 79, 763?854 (1999).",{"doi":5795},"10.1152\u002Fphysrev.1999.79.3.763",{"id":28,"text":5797,"url":28,"identifiers":5798},"Budd, S. L. & Nicholls, D. G. A reevaluation of the role of mitochondria in neuronal Ca2+ homeostasis. J. Neurochem. 66, 403?411 ( 1996).",{"doi":5799},"10.1046\u002Fj.1471-4159.1996.66010403.x",{"id":28,"text":5801,"url":28,"identifiers":5802},"Jouaville, L. S., Ichas, F., Holmuhamedor, E. L., Camacho, P. & Lechleiter, J. D. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes. Nature 377, 438?441 ( 1995).",{"doi":5803},"10.1038\u002F377438a0",{"id":28,"text":5805,"url":28,"identifiers":5806},"Collins, T. J., Lipp, P., Berridge, M. J., Li, W. & Bootman, M. D. Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization. Biochem. J. 347, 593?600 (2000).",{"doi":5807},"10.1042\u002Fbj3470593",{"id":28,"text":5809,"url":28,"identifiers":5810},"Duchen, M. R. Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J. Physiol. 516 , 1?17 (1999).",{"doi":5811},"10.1111\u002Fj.1469-7793.1999.001aa.x",{"id":28,"text":5813,"url":28,"identifiers":5814},"Rizzuto, R., Brini, M., Murgia, M. & Pozzan, T. Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262, 744?747 (1993).The first demonstration that mitochondria sense the high concentrations of Ca2+ that build up in the vicinity of intracellular channels such as the inositol-1,4,5-trisphosphate receptor.",{"doi":5815},"10.1126\u002Fscience.8235595",{"id":28,"text":5817,"url":28,"identifiers":5818},"Csordas, G., Thomas, A. P. & Hajnoczky, G. Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J. 18, 96?108 (1999).",{"doi":5819},"10.1093\u002Femboj\u002F18.1.96",{"id":28,"text":5821,"url":28,"identifiers":5822},"Leissring, M. A. et al. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J. Cell Biol. 149, 793?797 (2000).",{"doi":5823},"10.1083\u002Fjcb.149.4.793",{"id":28,"text":5825,"url":28,"identifiers":5826},"Bernadi, P. Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol. Rev. 79, 1127? 1155 (1999).",{"doi":5827},"10.1152\u002Fphysrev.1999.79.4.1127",{"id":28,"text":5829,"url":28,"identifiers":5830},"Ichas, F., Jouaville, L. S. & Mazat, J. P. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89, 1145?1153 (1997).",{"doi":5831},"10.1016\u002FS0092-8674(00)80301-3",{"id":28,"text":5833,"url":28,"identifiers":5834},"Berridge, M. J. Elementary and global aspects of calcium signalling. J. Physiol. 499, 291?306 ( 1997).",{"doi":5835},"10.1113\u002Fjphysiol.1997.sp021927",{"id":28,"text":5837,"url":28,"identifiers":5838},"Lipp, P. & Niggli, E. A hierarchical concept of cellular and subcellular Ca2+ signaling. Prog. Biophys. Mol. Biol. 65, 265?296 ( 1996).",{"doi":5839},"10.1016\u002FS0079-6107(96)00014-4",{"id":28,"text":5841,"url":28,"identifiers":5842},"Lipp, P. & Niggli, E. Fundamental calcium release events revealed by two-photon excitation photolysis of caged calcium in guinea-pig cardiac myocytes. J. Physiol. 508, 801? 809 (1998)",{"doi":5843},"10.1111\u002Fj.1469-7793.1998.801bp.x",{"id":28,"text":5845,"url":28,"identifiers":5846},"Bootman, M., Niggli, E., Berridge, M. J. & Lipp, P. Imaging the hierarchical Ca2+ signalling system in HeLa cells. J. Physiol. 499, 307?314 (1997).",{"doi":5847},"10.1113\u002Fjphysiol.1997.sp021928",{"id":28,"text":5849,"url":28,"identifiers":5850},"Cheng, H., Lederer, W. J. & Cannell, M. B. Calcium sparks ? elementary events underlying excitation-contraction coupling in heart-muscle. Science 262, 740?744 (1993). One of the first visualizations of the localized Ca2+ signal emerging from small groups of ryanodine receptors. Such elementary events are the basic building blocks of Ca2+ signals.",{"doi":5851},"10.1126\u002Fscience.8235594",{"id":28,"text":5853,"url":28,"identifiers":5854},"Yao, Y., Coi, J. & Parker, I. Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes. J. Physiol. 482, 533?553 (1995).",{"doi":5855},"10.1113\u002Fjphysiol.1995.sp020538",{"id":28,"text":5857,"url":28,"identifiers":5858},"Sun, X. -P., Callamaras, N., Marchant, J. S. & Parker, I. A continuum of InsP3-mediated elementary Ca2+ signalling events in Xenopus oocytes. J. Physiol. 509, 67?80 (1998).",{"doi":5859},"10.1111\u002Fj.1469-7793.1998.067bo.x",{"id":28,"text":5861,"url":28,"identifiers":5862},"Thomas, D. Lipp, P., Berridge, M. J. & Bootman, M. D. Hormone-evoked elementary Ca2+ signals are not stereotypic, but reflect activation of different size channel clusters and variable recruitment of channels within a cluster. J. Biol. Chem. 273, 27130?27136 (1998).",{"doi":5863},"10.1074\u002Fjbc.273.42.27130",{"id":28,"text":5865,"url":28,"identifiers":5866},"Lansley, A. B. & Sanderson, M. J. Regulation of airway ciliary activity by Ca2+: Simultaneous measurement of beat frequency and intracellular Ca2+. Biophys. J. 77, 629?638 ( 1999).",{"doi":5867},"10.1016\u002FS0006-3495(99)76919-5",{"id":28,"text":5869,"url":28,"identifiers":5870},"Robb-Gaspers, L. D. & Thomas, A. P. Coordination of Ca2+ signaling by intercellular propogation of Ca2+ waves in the intact liver. J. Biol. Chem. 270, 8102?8107 (1995). The first demonstration of intercellular Ca2+ waves travelling through large numbers of cells in an intact organ.",{"doi":5871},"10.1074\u002Fjbc.270.14.8102",{"id":28,"text":5873,"url":28,"identifiers":5874},"Zimmermann, B. & Walz, B. The mechanism mediating regenerative intercellular Ca2+ waves in the blowfly salivary gland. EMBO J. 18, 3222? 3231 (1999).",{"doi":5875},"10.1093\u002Femboj\u002F18.12.3222",{"id":28,"text":5877,"url":28,"identifiers":5878},"Tse, F. W. & Tse, A. Regulation of exocytosis via release of Ca2+ from intracellular stores. BioEssays 21, 861?865 (1999).",{"doi":5879},"10.1002\u002F(SICI)1521-1878(199910)21:10\u003C861::AID-BIES8>3.0.CO;2-9",{"id":28,"text":5881,"url":28,"identifiers":5882},"Maturana, A. D. et al. Angiotensin II negatively modulates L-type calcium channels through a pertussis toxin-sensitive G protein in adrenal glomerulosa cells . J. Biol. Chem. 274, 19943? 19948 (1999).",{"doi":5883},"10.1074\u002Fjbc.274.28.19943",{"id":28,"text":5885,"url":28,"identifiers":5886},"Lipp, P., Thomas, D., Berridge, M. J. & Bootman, M. D. Nuclear calcium signalling by individual cytoplasmic calcium puffs. EMBO J. 16, 7166?7173 ( 1997).A demonstration that Ca2+ puffs are concentrated around the nucleus and are therefore able to feed Ca2+ directly into the nucleoplasm.",{"doi":5887},"10.1093\u002Femboj\u002F16.23.7166",{"id":28,"text":5889,"url":28,"identifiers":5890},"DeKoninck, P. & Schulman, H. Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science 279, 227?230 (1998).",{"doi":5891},"10.1126\u002Fscience.279.5348.227",{"id":28,"text":5893,"url":28,"identifiers":5894},"Oancea, E. & Meyer, T. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95, 307?318 (1998).",{"doi":5895},"10.1016\u002FS0092-8674(00)81763-8",{"id":28,"text":5897,"url":28,"identifiers":5898},"Li, W. H., Llopis, J., Whitney, M., Zlokarnik, G. & Tsien, R. Y. Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature 392, 936?941 ( 1998).",{"doi":5899},"10.1038\u002F31965",{"id":28,"text":5901,"url":28,"identifiers":5902},"Dolmetsch, R. E., Xu, K. L. & Lewis, R. S. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392, 933? 936 (1998).",{"doi":5903},"10.1038\u002F31960",{"id":28,"text":5905,"url":28,"identifiers":5906},"Ding, J. M. et al. A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock. Nature 394, 381?384 (1998).",{"doi":5907},"10.1038\u002F28639",{"id":28,"text":5909,"url":28,"identifiers":5910},"Hamada, T. et al. The role of inositol trisphosphate-induced Ca2+ release from IP3-receptor in the rat suprachiasmatic nucleus on circadian entrainment mechanism. Neurosci. Lett. 263 , 125?128 (1999).",{"doi":5911},"10.1016\u002FS0304-3940(99)00111-1",{"id":28,"text":5913,"url":28,"identifiers":5914},"Miyazaki, S. et al. Essential role of the inositol 1,4,5-trisphosphate receptor\u002FCa2+ release channel in Ca2+ waves and Ca2+ oscillations at fertilization of mammalian eggs. Dev. Biol. 158, 62?78 (1993).",{"doi":5915},"10.1006\u002Fdbio.1993.1168",{"id":28,"text":5917,"url":28,"identifiers":5918},"Jones, K. T., Matsuda, M., Parrington, J., Katan, M. & Swann, K. Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate, and mouse eggs. Biochem. J. 346, 743?749 ( 2000).",{"doi":5919},"10.1042\u002Fbj3460743",{"id":28,"text":5921,"url":28,"identifiers":5922},"Swanson, C. A., Arkin, A. P. & Ross, J. An endogenous calcium oscillator may control early embryonic division. Proc. Natl Acad. Sci. USA 94, 1194?119 (1997).",{"doi":5923},"10.1073\u002Fpnas.94.4.1194",{"id":28,"text":5925,"url":28,"identifiers":5926},"Kono, T., Jones, K. T., BosMikich, A., Whittingham, D. G. & Carroll, J. A cell cycle-associated change in Ca2+ releasing activity leads to the generation of Ca2+ transients in mouse embryos during the first mitotic division . J. Cell Biol. 132, 915? 923(1996).",{"doi":5927},"10.1083\u002Fjcb.132.5.915",{"id":28,"text":5929,"url":28,"identifiers":5930},"Chang, D. C. & Meng, C. L A localized elevation of cytosolic-free calcium is associated with cytokinesis in the zebrafish embryo. J. Cell Biol. 131, 1539?1545 (1995).",{"doi":5931},"10.1083\u002Fjcb.131.6.1539",{"id":28,"text":5933,"url":28,"identifiers":5934},"Keating, T. J., Cork, R. J. & Robinson, K. R. Intracellular free calcium oscillations in normal and cleavage-blocked embryos and artificially activated eggs of Xenopus-laevis . J. Cell Sci. 107, 2229? 2237 (1994).",{"doi":5935},"10.1242\u002Fjcs.107.8.2229",{"id":28,"text":5937,"url":28,"identifiers":5938},"Kubota, H. Y., Yoshimoto, Y. & Hiramoto, Y. Oscillation of intracellular free calcium in cleaving and cleavage-arrested embryos of Xenopus-laevis. Dev. Biol. 160, 512?518 ( 1993).",{"doi":5939},"10.1006\u002Fdbio.1993.1325",{"id":28,"text":5941,"url":28,"identifiers":5942},"Stith, B. J., Goalstone, M., Silva, S. & Jaynes, C. Inositol 1,4,5-trisphosphate mass changes from fertilization through 1st-cleavage in Xenopus laevis . Mol. Biol. Cell 4, 435? 443 (1993).",{"doi":5943},"10.1091\u002Fmbc.4.4.435",{"id":28,"text":5945,"url":28,"identifiers":5946},"Han, J. K. Oscillation of inositol polyphosphates in the embryonic cleavage cycle of the Xenopus laevis. Biochem. Biophys. Res. Commun. 206, 775?780 (1995).",{"doi":5947},"10.1006\u002Fbbrc.1995.1109",{"id":28,"text":5949,"url":28,"identifiers":5950},"Ciapa, B., Pesando, D., Wilding, M. & Whitaker, M. Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels. Nature 368, 875?878 ( 1994).Some of the first evidence that cyclic changes in inositol-1,4,5-trisphosphate and Ca2+ are responsible for controlling certain cell-cycle events, especially those occurring at mitosis.",{"doi":5951},"10.1038\u002F368875a0",{"id":28,"text":5953,"url":28,"identifiers":5954},"Gilland, E., Miller, A. L., Karplus, E., Baker, R. & Webb, S. E. Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation. Proc. Natl Acad. Sci. USA 96, 157?161(1999).",{"doi":5955},"10.1073\u002Fpnas.96.1.157",{"id":28,"text":5957,"url":28,"identifiers":5958},"Webb, S. E. & Miller, A. L. Calcium signalling during zebrafish embryonic development. Bioessays 22, 113 ?123 (2000).",{"doi":5959},"10.1002\u002F(SICI)1521-1878(200002)22:2\u003C113::AID-BIES3>3.0.CO;2-L",{"id":28,"text":5961,"url":28,"identifiers":5962},"Creton, R., Speksnijder, J. E. & Jaffe, L. F. Patterns of free calcium in zebrafish embryos. J. Cell Sci. 111, 1613?1622 (1998).",{"doi":5963},"10.1242\u002Fjcs.111.12.1613",{"id":28,"text":5965,"url":28,"identifiers":5966},"Maslanski, J. A, Leshko, L. & Busa, W. B. Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction. Science 256, 243?245(1992).",{"doi":5967},"10.1126\u002Fscience.1314424",{"id":28,"text":5969,"url":28,"identifiers":5970},"Kume, S., Muto, A., Okano, H. & Mikoshiba, K. Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-trisphosphate during early embryogenesis in Xenopus laevis . Mech. Dev. 66, 157?168 (1997).",{"doi":5971},"10.1016\u002FS0925-4773(97)00101-9",{"id":28,"text":5973,"url":28,"identifiers":5974},"Reinhard, E. et al. Localized calcium signals in early zebrafish development. Dev. Biol. 170, 50?71( 1995).",{"doi":5975},"10.1006\u002Fdbio.1995.1194",{"id":28,"text":5977,"url":28,"identifiers":5978},"Creton, R., Kreiling, J. A. & Jaffe, L. F. Presence and roles of calcium gradients along the dorsal-ventral axis in Drosophila embryos. Dev. Biol. 217, 375?385 (2000).",{"doi":5979},"10.1006\u002Fdbio.1999.9542",{"id":28,"text":5981,"url":28,"identifiers":5982},"K¨hl, M., Sheldahl, L. C., Malbon, C. C. & Moon, R. T. Ca2+\u002Fcalmodulin-dependent protein kinase II is stimulated by Wnt and frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275, 12701?12711 (2000).",{"doi":5983},"10.1074\u002Fjbc.275.17.12701",{"id":28,"text":5985,"url":28,"identifiers":5986},"Kume, S. et al. Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos. Science 278, 1940?1943 (1997). A role for Ca2+ in setting up the dorsoventral axis in Xenopus oocytes was demonstrated by showing that the axis was modified by inhibiting the activity of the inositol-1,4,5-trisphosphate receptor.",{"doi":5987},"10.1126\u002Fscience.278.5345.1940",{"id":28,"text":5989,"url":28,"identifiers":5990},"Buonanno, A. & Fields, R. D. Gene regulation by patterned electrical activity during neural and skeletal muscle development. Curr. Opin. Neurobiol. 9, 110?120 ( 1999).",{"doi":5991},"10.1016\u002FS0959-4388(99)80014-2",{"id":28,"text":5993,"url":28,"identifiers":5994},"Ferrari, M. B., Ribbeck, K., Hagler, D. J. & Spitzer, N. C. A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes. J. Cell Biol. 141, 1349 ?1356 (1998).",{"doi":5995},"10.1083\u002Fjcb.141.6.1349",{"id":28,"text":5997,"url":28,"identifiers":5998},"Gu, X. N. & Spitzer, N. C. Breaking the code: Regulation of neuronal differentiation by spontaneous calcium transients. Dev. Neurosci. 19, 33?41(1997).",{"doi":5999},"10.1159\u002F000111183",{"id":28,"text":6001,"url":28,"identifiers":6002},"Carey, M. B. & Matsumoto, S. G. Spontaneous calcium transients are required for neuronal differentiation of murine neural crest. Dev. Biol. 215, 298?313 (1999).",{"doi":6003},"10.1006\u002Fdbio.1999.9433",{"id":28,"text":6005,"url":28,"identifiers":6006},"Gomez, T. M. & Spitzer, N. C. In vivo regulation of axon extension and pathfinding by growth-cone calcium transients. Nature 397, 350?355( 1999).By studying Ca2+ signals in individual neurons growing in vivo , it was possible to show that brief Ca2+ transients function both in the extension of the axon and in its ability to locate its target.",{"doi":6007},"10.1038\u002F16927",{"id":28,"text":6009,"url":28,"identifiers":6010},"Wong, R. O. L. Retinal waves and visual system development. Annu. Rev. Neurosci. 22, 29?47 ( 1999).",{"doi":6011},"10.1146\u002Fannurev.neuro.22.1.29",{"id":28,"text":6013,"url":28,"identifiers":6014},"Lu, K. P. & Means, A. R. Regulation of the cell-cycle by calcium and calmodulin. Endocrine Rev. 14, 40?58 (1993).",{"doi":6015},"10.1210\u002Fedrv-14-1-40",{"id":28,"text":6017,"url":28,"identifiers":6018},"Berridge, M. J. Calcium signalling and cell-proliferation. Bioessays 17, 491?500 (1995).",{"doi":6019},"10.1002\u002Fbies.950170605",{"id":28,"text":6021,"url":28,"identifiers":6022},"Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82?86 (1998).",{"doi":6023},"10.1038\u002F25764",{"id":28,"text":6025,"url":28,"identifiers":6026},"Akagi, K., Nagao, T. & Urushidani, T. Correlation between Ca2+ oscillation and cell proliferation via CCKB\u002Fgastrin receptor. Biochim. Biophys. Acta 1452, 243?253 (1999).",{"doi":6027},"10.1016\u002FS0167-4889(99)00137-8",{"id":28,"text":6029,"url":28,"identifiers":6030},"Scharenberg, A. M. & Kinet, J. P. Ptdlns-3,4,5-P 3: A regulatory nexus between tyrosine kinases and sustained calcium signals. Cell 94, 5?8 (1998).",{"doi":6031},"10.1016\u002FS0092-8674(00)81214-3",{"id":28,"text":6033,"url":28,"identifiers":6034},"Lewis, R. S. & Cahalan, M. D. Potassium and calcium channels in lymphocytes. Annu. Rev. Immunol. 13, 623?653 (1995).",{"doi":6035},"10.1146\u002Fannurev.iy.13.040195.003203",{"id":28,"text":6037,"url":28,"identifiers":6038},"Hoth, M., Fanger, C. M. & Lewis, R. S. Mitochondrial regulation of store-operated calcium signalling in T lymphocytes. J. Cell Biol. 137, 633?648 (1997).",{"doi":6039},"10.1083\u002Fjcb.137.3.633",{"id":28,"text":6041,"url":28,"identifiers":6042},"Crabtree, G. R. Generic signals and specific outcomes: Signaling through Ca2+, calcineurin, and NF-AT. Cell 96, 611? 614 (1999).",{"doi":6043},"10.1016\u002FS0092-8674(00)80571-1",{"id":28,"text":6045,"url":28,"identifiers":6046},"Timmerman, L. A., Clipstone, N. A., Ho, S. N., Northrop, J. P. & Crabtree, G. R. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 383, 837?840 ( 1996).",{"doi":6047},"10.1038\u002F383837a0",{"id":28,"text":6049,"url":28,"identifiers":6050},"Chawla, S., Hardingham, G. E., Quinn, D. R. & Bading, H. CBP: A signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science 281, 1505?1509 (1998).",{"doi":6051},"10.1126\u002Fscience.281.5382.1505",{"id":28,"text":6053,"url":28,"identifiers":6054},"Hardingham, G. E., Chawla, S., Cruzalegui, F. H. & Bading, H. Control of recruitment and transcription?activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels. Neuron 22, 789?798 ( 1999).",{"doi":6055},"10.1016\u002FS0896-6273(00)80737-0",{"id":28,"text":6057,"url":28,"identifiers":6058},"Wang, J. H., Moreira, K. M., Campos, B., Kaetzel, M. A. & Dedman, J. R. Targeted neutralization of calmodulin in the nucleus blocks DNA synthesis and cell cycle progression. Biochim. Biophys. Acta 1313, 223?228 (1996).",{"doi":6059},"10.1016\u002F0167-4889(96)00093-6",{"id":28,"text":6061,"url":28,"identifiers":6062},"Yang, H., Shen, F., Herenyiova, M. & Weber, G. Phospholipase C (EC 3. 1. 4. 11): A malignancy linked signal transduction enzyme. Anticancer Res. 18, 1399?1404 (1998).",{},{"id":28,"text":6064,"url":28,"identifiers":6065},"Smith, M. R. et al. Overexpression of phosphoinositide-specific phospholipase C γ in NIH 3T3 cells promotes transformation and tumorigenicity. Carcinogenesis 19, 177?185 (1998).",{"doi":6066},"10.1093\u002Fcarcin\u002F19.1.177",{"id":28,"text":6068,"url":28,"identifiers":6069},"Rizzo, M. T. & Weber, G. L. Phosphatidylinositol 4-kinase ? an enzyme linked with proliferation and malignancy. Cancer Res. 54, 2611?2614 ( 1994).",{},{"id":28,"text":6071,"url":28,"identifiers":6072},"Benzaquen, L. R., Brugnara, C., Byers, H. R., Gattoni-Celli, S. & Halperin, J. A. Clotrimazole inhibits cell proliferation in vitro and in vivo. Nature Med. 1, 534?540 (1995).",{"doi":6073},"10.1038\u002Fnm0695-534",{"id":28,"text":6075,"url":28,"identifiers":6076},"Nie, L., Mogami, H., Kanzaki, M., Shibata, H. & Kojima, I. Blockade of DNA synthesis induced by platelet-derived growth factor by tranilast, an inhibitor of Ca2+ entry, in vascular smooth muscle cells. Mol. Pharm. 50, 763?769 (1996).",{},{"id":28,"text":6078,"url":28,"identifiers":6079},"Haverstick, D. M., Heady, T. N., Macdonald, T. L. & Gray, L. S. Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Cancer Res. 60, 1002?1008 (2000).",{},{"id":28,"text":6081,"url":28,"identifiers":6082},"Kohn, E. C. et al. Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers. Cancer Res. 56 , 569?573 (1996).",{},{"id":28,"text":6084,"url":28,"identifiers":6085},"Gao, B. et al. Functional properties of a new voltage-dependent calcium channel α 2δ auxiliary subunit gene (CACNA2D2). J. Biol. Chem. 275, 12237?12242 ( 2000).One of the first indications that malignancy might be linked to an alteration in Ca2+ signalling.",{"doi":6086},"10.1074\u002Fjbc.275.16.12237",{"id":28,"text":6088,"url":28,"identifiers":6089},"Kass, G. E. N. & Orrenius, S. Calcium signaling and cytotoxicity. Environ. Health Perspect. 107, 25?35 (1999).",{},{"id":28,"text":6091,"url":28,"identifiers":6092},"Szalai, G., Krishnamurthy, R. & Hajnoczky, G. Apoptosis driven by IP3-linked mitochondrial calcium signals. EMBO J. 18, 6349? 6361 (1999).",{"doi":6093},"10.1093\u002Femboj\u002F18.22.6349",{"id":28,"text":6095,"url":28,"identifiers":6096},"Shimizu, S., Narita, M. & Tsujimoto, Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399, 483?487 (1999).",{"doi":6097},"10.1038\u002F20959",{"id":28,"text":6099,"url":28,"identifiers":6100},"Barr, P. J. & Tomei, L. D. Apoptosis and its role in human disease. Biotechnology 12, 487? 493 (1994).",{"doi":6101},"10.1038\u002Fnbt0594-487",{"id":28,"text":6103,"url":28,"identifiers":6104},"Reed, J. C. Bcl-2 and the regulation of programmed cell-death. J. Cell Biol. 124, 1?6 (1994 ).",{"doi":6105},"10.1083\u002Fjcb.124.1.1",{"id":28,"text":6107,"url":28,"identifiers":6108},"Murphy, A., Bredesen, D. E., Cortopassi, G., Wang, E. & Fiskum, G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc. Natl Acad. Sci. USA 93, 9893?9898 ( 1996).",{"doi":6109},"10.1073\u002Fpnas.93.18.9893",{"id":28,"text":6111,"url":28,"identifiers":6112},"Vander Heiden, M., Chandel, N. S., Williamson, E. K., Schumacker, P. T. & Thompson, C. B. Bcl-x L regulates the membrane potential and volume homeostasis of mitochondria . Cell 91, 627?637 (1997).",{"doi":6113},"10.1016\u002FS0092-8674(00)80450-X",{"id":28,"text":6115,"url":28,"identifiers":6116},"Zhu, L. P. et al. Modulation of mitochondrial Ca2+ homeostasis by Bcl-2. J. Biol. Chem. 274, 33267? 33273 (1999).Evidence that mitochondrial metabolism can be modulated by the anti-apoptotic modulator Bcl-2.",{"doi":6117},"10.1074\u002Fjbc.274.47.33267",{"id":28,"text":6119,"url":28,"identifiers":6120},"Kuo, T. H. et al. Modulation of endoplasmic reticulum calcium pump by Bcl-2 . Oncogene 17, 1903?1910 (1998).",{"doi":6121},"10.1038\u002Fsj.onc.1202110",{"id":28,"text":6123,"url":28,"identifiers":6124},"Foyouzi-Youssefi, R. et al. Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum. Proc. Natl Acad. Sci. USA 97, 5723?5728 (2000)",{"doi":6125},"10.1073\u002Fpnas.97.11.5723",{"id":28,"text":6127,"url":28,"identifiers":6128},"Pinton, P. et al. Reduced loading on intracellular Ca2+ stores and downregulation of capacitative Ca2+ influx in Bcl-2-overexpressing cells. J. Biol. Chem. 275, 857? 862 (2000).",{},{"id":28,"text":6130,"url":28,"identifiers":6131},"Schlossmann, J. et al. Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ. Nature 404, 197?201 ( 2000).",{"doi":6132},"10.1038\u002F35004606",{"id":28,"text":6134,"url":28,"identifiers":6135},"Morimoto, A. M. et al. The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase-activity. Oncogene 19, 200?209 (2000).",{"doi":6136},"10.1038\u002Fsj.onc.1203288",{"id":28,"text":6138,"url":28,"identifiers":6139},"Lev, S. et al. Protein-tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion-channel and map kinase functions. Nature 376, 737?745 (1995).",{"doi":6140},"10.1038\u002F376737a0",{"id":28,"text":6142,"url":28,"identifiers":6143},"Brinson, A. E. et al. Regulation of a calcium-dependent tyrosine kinase in vascular smooth muscle cells by angiotensin II and platelet-derived growth factor. Dependence on calcium and the actin cytoskeleton. J. Biol. Chem. 273, 1711?1718 ( 1998).",{"doi":6144},"10.1074\u002Fjbc.273.3.1711",{"id":28,"text":6146,"url":28,"identifiers":6147},"Prenzel, N. et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinases of proHB?EGF. Nature 402, 884?888 (1999).",{"doi":6148},"10.1038\u002F47260",{"id":6150,"createTime":6151,"updateTime":6151,"relativeEntities":6152,"slug":6153,"properties":6154,"entityType":971,"verifyStatus":26,"verifyTime":6151,"verifyNote":972,"languages":6165,"translateLanguages":28,"viewCount":32,"primaryUrl":6166,"fullTextUrl":28,"authors":6167,"publicationType":1063,"publisherRelationship":6214,"citationCount":6267,"citationInfo":6268,"publishDate":6278,"publishYear":6269,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":6279,"openAccess":28,"references":6280,"isForceReanalyzing":1713},"bbfb3ab3-9e09-44d1-8261-1728f4544daf","2024-09-19T15:46:56.504+00:00",[],"Calcium-signalling-dynamics-homeostasis-and-remodelling",{"openalex":6155,"mag":6157,"title":6159,"pm":6161,"doi":6163},{"VOID":6156},"W1485297825",{"VOID":6158},"1485297825",{"EN":6160},"Calcium signalling: dynamics, homeostasis and remodelling",{"VOID":6162},"12838335",{"VOID":6164},"10.1038\u002Fnrm1155",[31],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnrm1155",[6168,6183,6197],{"id":6169,"sortIndex":32,"researcher":28,"roles":6170,"affiliations":6171,"properties":6180,"displayName":5604,"givenName":28,"familyName":28},"34262416-e583-45ce-9052-b5d641adc0d6",[],[6172],{"id":6173,"sortIndex":32,"affiliation":6174,"properties":28},"3c584cc9-097d-4364-a56a-b26081364aff",{"id":6173,"createTime":28,"updateTime":28,"relativeEntities":6175,"slug":28,"properties":6176,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6179,"statistic":28},[],{"title":6177},{"EN":6178},"Laboratory of Molecular Signalling, The Babraham Institute, Babraham, UK",[],{"title":6181,"openalex":6182},{"EN":5604},{"VOID":5606},{"id":6184,"sortIndex":40,"researcher":28,"roles":6185,"affiliations":6186,"properties":6193,"displayName":5638,"givenName":28,"familyName":28},"264988be-3e23-4e92-989a-7407b1e545a2",[],[6187],{"id":6173,"sortIndex":32,"affiliation":6188,"properties":28},{"id":6173,"createTime":28,"updateTime":28,"relativeEntities":6189,"slug":28,"properties":6190,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6192,"statistic":28},[],{"title":6191},{"EN":6178},[],{"orcid":6194,"title":6195,"openalex":6196},{"VOID":5636},{"EN":5638},{"VOID":5640},{"id":6198,"sortIndex":123,"researcher":28,"roles":6199,"affiliations":6200,"properties":6207,"displayName":6211,"givenName":28,"familyName":28},"eaf7403f-770c-45d6-b24c-005a517b0d50",[],[6201],{"id":6173,"sortIndex":32,"affiliation":6202,"properties":28},{"id":6173,"createTime":28,"updateTime":28,"relativeEntities":6203,"slug":28,"properties":6204,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6206,"statistic":28},[],{"title":6205},{"EN":6178},[],{"orcid":6208,"title":6210,"openalex":6212},{"VOID":6209},"https:\u002F\u002Forcid.org\u002F0000-0001-7065-3523",{"EN":6211},"H. 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J., Lipp, P. & Bootman, M. D. The versatility and universality of calcium signalling. Nature Rev. Mol. Cell Biol. 1, 11–21 (2000).",{"doi":5586},{"id":28,"text":6285,"url":28,"identifiers":6286},"Carafoli, E., Santella, L., Brance, D. & Brisi, M. Generation, control, and processing of cellular calcium signals. Crit. Rev. Biochem. Mol. Biol. 36, 107–260 (2001).",{"doi":6287},"10.1080\u002F20014091074183",{"id":28,"text":6289,"url":28,"identifiers":6290},"Bootman, M. D., Berridge, M. J. & Roderick, H. L. Calcium signalling: more messengers, more channels, more complexity. Curr. Biol. 12, R563–R565 (2002).",{"doi":6291},"10.1016\u002FS0960-9822(02)01055-2",{"id":28,"text":6293,"url":28,"identifiers":6294},"Kelley, G. G., Reks, S. E., Ondrako, J. M. & Smrcka, A. V. Phospholipase Cε: a novel Ras effector. EMBO J. 20, 743–754 (2001).",{"doi":6295},"10.1093\u002Femboj\u002F20.4.743",{"id":28,"text":6297,"url":28,"identifiers":6298},"Saunders, C. M. et al. PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development. Development 129, 3533–3544 (2002). The mystery of how mammalian eggs are activated seems to have been solved by the discovery that the sperm injects a new PLC, PLCζ, into the egg to stimulate the production of Ins(1,4,5)P 3.",{"doi":6299},"10.1242\u002Fdev.129.15.3533",{"id":28,"text":6301,"url":28,"identifiers":6302},"Van der Wal, J., Habets, R., Várnai, P., Balla, T. & Jalink, K. Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer. J. Biol. Chem. 276, 15337–15344 (2001).",{"doi":6303},"10.1074\u002Fjbc.M007194200",{"id":28,"text":6305,"url":28,"identifiers":6306},"Kim, D. et al. Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature 389, 290–293 (1997).",{"doi":6307},"10.1038\u002F38508",{"id":28,"text":6309,"url":28,"identifiers":6310},"Tanaka, J. et al. Gq protein α-subunits Gαq and Gα11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Eur. J. Neurosci. 12, 781–792 (2000).",{"doi":6311},"10.1046\u002Fj.1460-9568.2000.00959.x",{"id":28,"text":6313,"url":28,"identifiers":6314},"Kawabate, S. et al. Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors. Nature 383, 89–92 (1996).",{"doi":6315},"10.1038\u002F383089a0",{"id":28,"text":6317,"url":28,"identifiers":6318},"Luo, X., Popov, S., Bera, A. K., Wilkie, T. M. & Muallem, S. RGS proteins provide biochemical control of agonist-evoked [Ca2+]I oscillations. Mol. Cell 7, 651–660 (2001).",{"doi":6319},"10.1016\u002FS1097-2765(01)00211-8",{"id":28,"text":6321,"url":28,"identifiers":6322},"Cancela, J. M., Churchill, G. C. & Galione, A. Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells. Nature 398, 74–76 (1999).",{"doi":5783},{"id":28,"text":6324,"url":28,"identifiers":6325},"Patel, S., Churchill, G. C. & Galione, A. Coordination of Ca2+ signalling by NAADP. Trends Biochem. Sci. 26, 482–489 (2001).",{"doi":6326},"10.1016\u002FS0968-0004(01)01896-5",{"id":28,"text":6328,"url":28,"identifiers":6329},"Cancela, J. M., Van Coppenolle, F., Galione, A., Tepikin, A. V. & Petersen, O. H. Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers. EMBO J. 21, 909–919 (2002). This paper describes the complex interactions among the different intracellular Ca2+-mobilizing messengers such as Ins(1,4,5)P 3 , cADPR and NAADP.",{"doi":6330},"10.1093\u002Femboj\u002F21.5.909",{"id":28,"text":6332,"url":28,"identifiers":6333},"Lee, H. C. Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP. Physiol. Rev. 77, 1133–1164 (1997).",{"doi":6334},"10.1152\u002Fphysrev.1997.77.4.1133",{"id":28,"text":6336,"url":28,"identifiers":6337},"Tohgo, A. et al. Lysine 129 of CD38 (ADP-ribosyl cyclase\u002Fcyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase. J. Biol. Chem. 272, 3879–3882 (1997).",{"doi":6338},"10.1074\u002Fjbc.272.7.3879",{"id":28,"text":6340,"url":28,"identifiers":6341},"Wilson, H. L. et al. ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor: a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction. J. Biol. Chem. 276, 11180–11188 (2001).",{"doi":6342},"10.1074\u002Fjbc.M004849200",{"id":28,"text":6344,"url":28,"identifiers":6345},"Churchill, G. C. et al. NAADP mobilizes Ca2+ from reserve granules, lysosome-related organelles, in sea urchin eggs. Cell 111, 703–708 (2002).",{"doi":6346},"10.1016\u002FS0092-8674(02)01082-6",{"id":28,"text":6348,"url":28,"identifiers":6349},"Hua, S. -Y. et al. Cyclic ADP-ribose modulates Ca2+ release channels for activation by physiological Ca2+ entry in bullfrog sympathetic neurons. Neuron 12, 1073–1079 (1994).",{"doi":6350},"10.1016\u002F0896-6273(94)90315-8",{"id":28,"text":6352,"url":28,"identifiers":6353},"Hashii, M., Minabe, Y. & Higashida, H. cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108–15 neuronal cells. Biochem. J. 345, 207–215 (2000).",{"doi":6354},"10.1042\u002Fbj3450207",{"id":28,"text":6356,"url":28,"identifiers":6357},"Currie, K. P. M., Swann, K., Galione, A. & Scott, R. H. Activation of Ca2+-dependent currents in cultured rat dorsal root ganglion neurones by a sperm factor and cyclic ADP-ribose. Mol. Biol. Cell 3, 1415–1425 (1992).",{"doi":6358},"10.1091\u002Fmbc.3.12.1415",{"id":28,"text":6360,"url":28,"identifiers":6361},"Cui, Y., Galione, A. & Terrar, D. A. Effects of photoreleased cADP-ribose on calcium transients and calcium sparks in myocytes isolated from guinea-pig and rat ventricle. Biochem. J. 342, 269–273 (1999).",{"doi":6362},"10.1042\u002Fbj3420269",{"id":28,"text":6364,"url":28,"identifiers":6365},"Empson, R. M. & Galione, A. Cyclic ADP-ribose enhances coupling between voltage-gated Ca2+ entry and intracellular Ca2+ release. J. Biol. Chem. 272, 20967–20970 (1997).",{"doi":6366},"10.1074\u002Fjbc.272.34.20967",{"id":28,"text":6368,"url":28,"identifiers":6369},"Lukyanenko, V., Györke, I., Wiesner, T. F. & Györke, S. Potentiation of Ca2+ release by cADP-ribose in the heart is mediated by enhanced SR Ca2+ uptake into the sarcoplasmic reticulum. Circ. Res. 89, 614–622 (2001). This paper indicates that cADPR might function to enhance Ca2+ signalling by stimulating the SERCA pump to increase the luminal level of Ca2+.",{"doi":6370},"10.1161\u002Fhh1901.098066",{"id":28,"text":6372,"url":28,"identifiers":6373},"Rakovic, S. et al. An antagonist of cADP-ribose inhibits arrhythmogenic oscillations of intracellular Ca2+ in heart cells. J. Biol. Chem. 274, 17820–17827 (1999).",{"doi":6374},"10.1074\u002Fjbc.274.25.17820",{"id":28,"text":6376,"url":28,"identifiers":6377},"Noguchi, N. et al. Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. J. Biol. Chem. 272, 3133–3136 (1997).",{"doi":6378},"10.1074\u002Fjbc.272.6.3133",{"id":28,"text":6380,"url":28,"identifiers":6381},"Koizumi. S., Lipp, P., Berridge, M. J. & Bootman, M. D. Regulation of ryanodine receptor opening by lumenal Ca2+ underlies quantal Ca2+ release in PC12 cells. J. Biol. Chem. 274, 33327–33333 (1999).",{"doi":6382},"10.1074\u002Fjbc.274.47.33327",{"id":28,"text":6384,"url":28,"identifiers":6385},"Young, K. W. et al. Lysophosphatidic acid-induced Ca2+ mobilisation requires intracellular sphingosine 1-phosphate production: potential involvement of endogenous Edg-4 receptors. J. Biol. Chem. 275, 38532–38539 (2000). Evidence of Ca2+ mobilization by distinct pathways using Ins(1,4,5)P 3 or S1P within the same cell.",{"doi":6386},"10.1074\u002Fjbc.M006631200",{"id":28,"text":6388,"url":28,"identifiers":6389},"Melendez, A. J. & Khaw, A. A. Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem. 277, 17255–17262 (2002).",{"doi":6390},"10.1074\u002Fjbc.M110944200",{"id":28,"text":6392,"url":28,"identifiers":6393},"Schnurbus, R., De Pietri Tonelli, D., Grohovaz, F. & Zacchetti, D. Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine. Biochem. J. 362, 183–189 (2002). SCaMPER has been widely cited as a receptor for Ca2+-mobilizing sphingolipids. This paper presents a detailed characterization of the SCaMPER protein, which indicates that it is unlikely to function as a conventional Ca2+ channel.",{"doi":6394},"10.1042\u002Fbj3620183",{"id":28,"text":6396,"url":28,"identifiers":6397},"Mignen, O. & Shuttleworth, T. J. IARC, a novel arachidonate-regulated, noncapacitative Ca2+ entry channel. J. Biol. Chem. 275, 9114–9119 (2000). The principal route for hormone-stimulated Ca2+ entry into cells was believed to be by a store-operated mechanism. Emerging evidence indicates that many cells express a distinct Ca2+-entry pathway that is activated by arachidonic acid.",{"doi":5751},{"id":28,"text":6399,"url":28,"identifiers":6400},"Clapham, D. E., Runnels, L. W. & Strübing, C. The TRP ion channel family. Nature Rev. Neurosci. 2, 387–396 (2001).",{"doi":6401},"10.1038\u002F35077544",{"id":28,"text":6403,"url":28,"identifiers":6404},"Minke, B. & Cook, B. TRP channel proteins and signal transduction. Physiol. Rev. 82, 429–472 (2002).",{"doi":6405},"10.1152\u002Fphysrev.00001.2002",{"id":28,"text":6407,"url":28,"identifiers":6408},"Montell, C., Birnbaumer, L. & Flockerzi, V. The TRP channels, a remarkably functional family. Cell 108, 595–598 (2002).",{"doi":6409},"10.1016\u002FS0092-8674(02)00670-0",{"id":28,"text":6411,"url":28,"identifiers":6412},"Vennekens, R., Voets, T., Bindels, R. J. M., Droogmans, G. & Nilius, B. Current understanding of mammalian TRP homologues. Cell Calcium 31, 253–264 (2002).",{"doi":6413},"10.1016\u002FS0143-4160(02)00055-6",{"id":28,"text":6415,"url":28,"identifiers":6416},"Nadif Kasri, N. et al. The role of calmodulin for inositol 1,4,5-trisphosphate receptor function. Biochim. Biophys. Acta 1600, 19–31 (2002).",{"doi":6417},"10.1016\u002FS1570-9639(02)00440-5",{"id":28,"text":6419,"url":28,"identifiers":6420},"Taylor, C. W. & Laude, A. J. IP3 receptors and their regulation by calmodulin and cytosolic Ca2+. Cell Calcium 32, 321–334 (2002).",{"doi":6421},"10.1016\u002FS0143416002001859",{"id":28,"text":6423,"url":28,"identifiers":6424},"Yang, J. et al. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca2+ release channels. Proc. Natl Acad. Sci. USA 99, 7711–7716 (2002).",{"doi":6425},"10.1073\u002Fpnas.102006299",{"id":28,"text":6427,"url":28,"identifiers":6428},"Roderick, H. L. et al. Inhibition of inositol 1,4,5-trisphosphate (InsP3)-induced calcium release by neuronal calcium binding proteins (CaBP). J. Physiol. (Lond.) 547P, PC36 (2003).",{},{"id":28,"text":6430,"url":28,"identifiers":6431},"Koller, A. et al. Association of phospholamban with a cGMP kinase signaling complex. Biochem. Biophys. Res. Commun. 300, 155–160 (2003).",{"doi":6432},"10.1016\u002FS0006-291X(02)02799-7",{"id":28,"text":6434,"url":28,"identifiers":6435},"Yokoyama, K. et al. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor. EMBO J. 21, 83–92 (2002).",{"doi":6436},"10.1093\u002Femboj\u002F21.1.83",{"id":28,"text":6438,"url":28,"identifiers":6439},"DeSouza, N. et al. Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. J. Biol. Chem. 277, 39397–39400 (2002).",{"doi":6440},"10.1074\u002Fjbc.M207059200",{"id":28,"text":6442,"url":28,"identifiers":6443},"Bezprozvanny, I., Watras, J. & Ehrlich, B. E. Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 351, 751–754 (1991). A classic paper that described the co-activation of Ins(1,4,5)P 3 Rs by Ca2+ and Ins(1,4,5)P 3.",{"doi":6444},"10.1038\u002F351751a0",{"id":28,"text":6446,"url":28,"identifiers":6447},"Balshaw, D. M., Xu, L., Yamaguchi, N., Pasek, D. A. & Meissner, G. Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor). J. Biol. Chem. 276, 20144–20153 (2001).",{"doi":6448},"10.1074\u002Fjbc.M010771200",{"id":28,"text":6450,"url":28,"identifiers":6451},"Marks, A. R., Marx, S. O. & Reiken, S. Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine\u002Fisoleucine zippers. Trends Cardiovasc. Med. 12, 166–170 (2002).",{"doi":6452},"10.1016\u002FS1050-1738(02)00156-1",{"id":28,"text":6454,"url":28,"identifiers":6455},"Marx, S. O. et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101, 365–376 (2000).",{"doi":6456},"10.1016\u002FS0092-8674(00)80847-8",{"id":28,"text":6458,"url":28,"identifiers":6459},"Lokuta, A. J., Meyers, M. B., Sander, P. R., Fishman, G. I. & Valdivia, H. H. Modulation of cardiac ryanodine receptors by sorcin. J. Biol. Chem. 272, 25333–25338 (1997).",{"doi":6460},"10.1074\u002Fjbc.272.40.25333",{"id":28,"text":6462,"url":28,"identifiers":6463},"Muller, F. U. et al. Junctional sarcoplasmic reticulum transmembrane proteins in the heart. Basic Res. Cardiol. 97, I52–I55 (2002).",{"doi":6464},"10.1007\u002Fs003950200030",{"id":28,"text":6466,"url":28,"identifiers":6467},"Zhang, L., Kelley, J., Schmeisser, G., Kobayashi, Y. M. & Jones, L. R. Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. J. Biol. Chem. 272, 23389–23397 (1997). Much attention has focused on accessory cytosolic proteins as modulators of the RYRs, but there also is evidence that the transmembrane proteins junctin and triadin cooperate with the luminal protein calsequestrin to regulate the activity of these release channels.",{"doi":6468},"10.1074\u002Fjbc.272.37.23389",{"id":28,"text":6470,"url":28,"identifiers":6471},"Nauli, S. M. et al. J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genet. 33, 129–137 (2003).",{"doi":6472},"10.1038\u002Fng1076",{"id":28,"text":6474,"url":28,"identifiers":6475},"Koulen, P. et al. Polycystin-2 is an intracellular calcium release channel. Nature Cell Biol. 4, 191–197 (2002). The cellular locations and functions of polycystins are not well understood, but they somehow seem to regulate epithelial-cell proliferation. This paper presents evidence that one member of the family forms functional channels that can function in a Ca2+-induced Ca2+ release mode.",{"doi":6476},"10.1038\u002Fncb754",{"id":28,"text":6478,"url":28,"identifiers":6479},"Gonzalez-Perrett, S. et al. Polycystin-2, the protein mutated in autosomal dominant polycystic kidney (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc. Natl Acad. Sci. USA 98, 1182–1187 (2001).",{"doi":6480},"10.1073\u002Fpnas.98.3.1182",{"id":28,"text":6482,"url":28,"identifiers":6483},"Cai, Y. et al. Identification and characterisation of polycystin-2, the PKD2 gene product. J. Biol. Chem. 274, 28557–28565 (1999).",{"doi":6484},"10.1074\u002Fjbc.274.40.28557",{"id":28,"text":6486,"url":28,"identifiers":6487},"John, L. M., Mosquera-Caro, M., Camacho, P. & Lechleiter, J. D. Control of IP3-mediated Ca2+ puffs in Xenopus laevis oocytes by the Ca2+-binding protein parvalbumin. J. Physiol. (Lond.) 535, 3–16 (2001).",{"doi":6488},"10.1111\u002Fj.1469-7793.2001.t01-2-00003.x",{"id":28,"text":6490,"url":28,"identifiers":6491},"Palecek, J., Lips, M. B. & Keller, B. U. Calcium dynamics and buffering in motoneurones of the mouse spinal cord. J. Physiol. (Lond.) 520, 485–502 (1999).",{"doi":6492},"10.1111\u002Fj.1469-7793.1999.00485.x",{"id":28,"text":6494,"url":28,"identifiers":6495},"Schwaller, B. et al. Prolonged contraction–relaxation cycle of fast-twitch muscles in parvalbumin knockout mice. Am. J. Physiol. 276, C395–C403 (1999).",{"doi":6496},"10.1152\u002Fajpcell.1999.276.2.C395",{"id":28,"text":6498,"url":28,"identifiers":6499},"Caillard, O. et al. Role of calcium-binding protein parvalbumin in short-term synaptic plasticity. Proc. Natl Acad. Sci. USA 97, 13372–13377 (2000).",{"doi":6500},"10.1073\u002Fpnas.230362997",{"id":28,"text":6502,"url":28,"identifiers":6503},"Collins, T. J., Lipp, P., Berridge, M. J. & Bootman, M. D. Mitochondrial Ca2+ uptake depends on the spatial and temporal profile of cytosolic Ca2+ signals. J. Biol. Chem. 276, 26411–26420 (2001).",{"doi":6504},"10.1074\u002Fjbc.M101101200",{"id":28,"text":6506,"url":28,"identifiers":6507},"Colegrove, S. L., Albrecht, M. A. & Friel, D. D. Quantitative analysis of mitochondrial Ca2+ uptake and release in sympathetic neurons. J. Gen. Physiol. 115, 371–388 (2000).",{"doi":6508},"10.1085\u002Fjgp.115.3.371",{"id":28,"text":6510,"url":28,"identifiers":6511},"Caride, A. J. et al. Delayed activation of the plasma membrane calcium pump by a sudden increase in Ca2+: fast pumps reside in fast cells. Cell Calcium 30, 49–57 (2001).",{"doi":6512},"10.1054\u002Fceca.2001.0212",{"id":28,"text":6514,"url":28,"identifiers":6515},"Wuytack, F., Raeymaekers, L. & Missiaen, L. The molecular physiology of the SERCA and SPCA pumps. Cell Calcium 32, 279–305 (2002).",{"doi":6516},"10.1016\u002FS0143416002001847",{"id":28,"text":6518,"url":28,"identifiers":6519},"Ozil, J. P. & Swann, K. Stimulation of repetitive calcium transients in mouse eggs. J. Physiol. (Lond.) 483, 331–346 (1995)",{"doi":6520},"10.1113\u002Fjphysiol.1995.sp020589",{"id":28,"text":6522,"url":28,"identifiers":6523},"Gomez, T. M., Snow, D. M. & Letourneau, P. C. Characterization of spontaneous calcium transients in nerve growth cones and their effect on growth cone migration. Neuron 14, 1233–1246 (1995).",{"doi":6524},"10.1016\u002F0896-6273(95)90270-8",{"id":28,"text":6526,"url":28,"identifiers":6527},"Gomez, T. M. Robles, E., Poo, M -m. & Spitzer, N. C. (2001) Filopodial calcium transients promote substrate-dependent growth cone turning. Science 291, 1983–1987 (2001). This paper shows that filopodia scout ahead of neuronal growth cones to detect preferred growth substrates. When engaged, these substrates induce local Ca2+ signals in the filopodia that are transmitted back to the growth cone to deflect its path. An increased frequency of Ca2+ transients correlates with greater turning.",{"doi":6528},"10.1126\u002Fscience.1056490",{"id":28,"text":6530,"url":28,"identifiers":6531},"Tang, F., Dent, E. W. & Kalil, K. Spontaneous calcium transients in developing cortical neurons regulate axonal outgrowth. J. Neurosci. 23, 927–936 (2003).",{"doi":6532},"10.1523\u002FJNEUROSCI.23-03-00927.2003",{"id":28,"text":6534,"url":28,"identifiers":6535},"Komuro, H. & Rakic, P. Intracellular Ca2+ fluctuations modulate the rate of neuronal migration. Neuron 17, 275–285 (1996).",{"doi":6536},"10.1016\u002FS0896-6273(00)80159-2",{"id":28,"text":6538,"url":28,"identifiers":6539},"Ciccolini, F. et al. Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation. J. Neurosci. 23, 103–111 (2003).",{"doi":6540},"10.1523\u002FJNEUROSCI.23-01-00103.2003",{"id":28,"text":6542,"url":28,"identifiers":6543},"Ehrhardt, D. W., Wais, R. & Long, S. R. Calcium spiking in plant root hairs responding to Rhizobium nodulation signals. Cell 85, 673–681 (1996).",{"doi":6544},"10.1016\u002FS0092-8674(00)81234-9",{"id":28,"text":6546,"url":28,"identifiers":6547},"Tashiro, A., Goldberg, J. & Yuste, R. Calcium oscillations in neocortical astrocytes under epileptiform conditions. J. Neurobiol. 50, 45–55 (2001).",{"doi":6548},"10.1002\u002Fneu.10019",{"id":28,"text":6550,"url":28,"identifiers":6551},"Ferrari, M. B., Ribbeck, K., Hagler, D. J. Jr. & Spitzer, N. C. A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes. J. Cell Biol. 141, 1349–1356 (1998).",{"doi":5995},{"id":28,"text":6553,"url":28,"identifiers":6554},"Uhlén, P. et al. α-Haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells. Nature 277, 694–697 (2000).",{"doi":6555},"10.1038\u002F35015091",{"id":28,"text":6557,"url":28,"identifiers":6558},"Giannone, G., Rondé, P., Gaire, M., Haiech, J. & Takeda, K. Calcium oscillations trigger focal adhesion disassembly in human U87 astrocytoma cells. J. Biol. Chem. 277, 26364–26371 (2002).",{"doi":6559},"10.1074\u002Fjbc.M203952200",{"id":28,"text":6561,"url":28,"identifiers":6562},"Tse, A., Tse, F. W., Almers, W. & Hille, B. Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropes. Science 260, 82–84 (1993).",{"doi":6563},"10.1126\u002Fscience.8385366",{"id":28,"text":6565,"url":28,"identifiers":6566},"Hajnóczky, G., Robb-Gaspers, L. D., Seitz, M. B. & Thomas, A. P. Decoding of cytosolic calcium oscillations in the mitochondria. Cell 82, 415–424 (1995).",{"doi":6567},"10.1016\u002F0092-8674(95)90430-1",{"id":28,"text":6569,"url":28,"identifiers":6570},"Dolmetsch, R. E., Xu, K. & Lewis, R. S. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392, 933–936 (1998).",{"doi":5903},{"id":28,"text":6572,"url":28,"identifiers":6573},"Li, W -h., Liopis, J., Whitney, M., Xlokarnik, G. & Tsien, R. Y. Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature 392, 936–941 (1998). References 74 and 75 have helped to establish the importance of frequency-modulated Ca2+ signalling as a mechanism to control differential gene activation.",{"doi":5899},{"id":28,"text":6575,"url":28,"identifiers":6576},"Haisenleder, D. J. et al. Gonadotrophin subunit transcriptional responses to calcium signals in the rat: evidence for regulation by pulse frequency. Biol. Reprod. 65, 1789–1793 (2001).",{"doi":6577},"10.1095\u002Fbiolreprod65.6.1789",{"id":28,"text":6579,"url":28,"identifiers":6580},"Buonanno, A. & Fields, R. D. Gene regulation by patterned electrical activity during neural and skeletal muscle development. Curr. Opin. Neurobiol. 9, 110–120 (1999).",{"doi":5991},{"id":28,"text":6582,"url":28,"identifiers":6583},"Olsen, E. A. & Williams, R. S. Remodelling muscles with calcineurin. Bioessays 22, 510–519 (2000).",{"doi":6584},"10.1002\u002F(SICI)1521-1878(200006)22:6\u003C510::AID-BIES4>3.0.CO;2-1",{"id":28,"text":6586,"url":28,"identifiers":6587},"De Koninck, P. & Shulman, H. Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science 279, 227–230 (1998).",{"doi":5891},{"id":28,"text":6589,"url":28,"identifiers":6590},"Oancea, E. & Meyer, T. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95, 307–318 (1998).",{"doi":5895},{"id":28,"text":6592,"url":28,"identifiers":6593},"Niggli, E. Localized intracellular calcium signaling in muscle: calcium sparks and calcium quarks. Annu. Rev. Physiol. 61, 311–335 (1999).",{"doi":6594},"10.1146\u002Fannurev.physiol.61.1.311",{"id":28,"text":6596,"url":28,"identifiers":6597},"Thomas, D. et al. Microscopic properties of elementary Ca2+ release sites in non-excitable cells. Curr. Biol. 10, 8–15 (2000).",{"doi":6598},"10.1016\u002FS0960-9822(99)00258-4",{"id":28,"text":6600,"url":28,"identifiers":6601},"Euler, T., Detwiler, P. B. & Denk, W. Directionally selective calcium signals in dendrites of starburst amacrine cells. Nature 418, 845–852 (2002).",{"doi":6602},"10.1038\u002Fnature00931",{"id":28,"text":6604,"url":28,"identifiers":6605},"Fauquier, T., Guérineau, N. C., McKinney, R. A., Bauer, K. & Mollard, P. Folliculostellate cell network: A route for long-distance communication in the anterior pituitary. Proc. Natl Acad. Sci. USA 98, 8891–8896 (2001).",{"doi":6606},"10.1073\u002Fpnas.151339598",{"id":28,"text":6608,"url":28,"identifiers":6609},"Wallingford, J. B., Ewald, A. J., Harland, R. M. & Fraser, S. E. Calcium signaling during convergent extension in Xenopus. Curr. Biol. 11, 652–661 (2001).",{"doi":6610},"10.1016\u002FS0960-9822(01)00201-9",{"id":28,"text":6612,"url":28,"identifiers":6613},"Robb-Gaspers, L. D. & Thomas, A. P. Coordination of Ca2+ signaling by intercellular propagation of Ca2+ waves in the intact liver. J. Biol. Chem. 270, 8102–8107 (1995).",{"doi":5871},{"id":28,"text":6615,"url":28,"identifiers":6616},"Yashiro, Y. & Duling, B. R. Integrated Ca2+ signaling between smooth muscle and endothelium of resistance vessels. Circ. Res. 87, 1048–1054 (2000).",{"doi":6617},"10.1161\u002F01.RES.87.11.1048",{"id":28,"text":6619,"url":28,"identifiers":6620},"Wang, S. -Q., Song, L. -S., Lakatta, E. G. & Cheng, H. Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature 410, 592–596 (2001).",{"doi":6621},"10.1038\u002F35069083",{"id":28,"text":6623,"url":28,"identifiers":6624},"Robert, V. et al. Beat-to-beat oscillations of mitochondrial [Ca2+] in cardiac cells. EMBO J. 20, 4998–5007 (2001).",{"doi":6625},"10.1093\u002Femboj\u002F20.17.4998",{"id":28,"text":6627,"url":28,"identifiers":6628},"Crabtree, G. R. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NFAT. Cell 96, 611–614 (1999).",{"doi":6043},{"id":28,"text":6630,"url":28,"identifiers":6631},"Mellström, B. & Naranjo, J. R. Mechanisms of Ca2+-dependent transcription. Curr. Opin. Neurobiol. 11, 312–319 (2001).",{"doi":6632},"10.1016\u002FS0959-4388(00)00213-0",{"id":28,"text":6634,"url":28,"identifiers":6635},"West, A. E. et al. Calcium regulation of neuronal gene expression. Proc. Natl Acad. Sci. USA 98, 11024–11031 (2001).",{"doi":6636},"10.1073\u002Fpnas.191352298",{"id":28,"text":6638,"url":28,"identifiers":6639},"McKinsey, T. A., Zhang, C. L. & Olsen, E. N. MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem. Sci. 27, 40–47 (2002).",{"doi":6640},"10.1016\u002FS0968-0004(01)02031-X",{"id":28,"text":6642,"url":28,"identifiers":6643},"Carafoli, E., Genazzani, A. & Guerini, D. Calcium controls the transcription of its own transporters and channels in developing neurons. Biochem. Biophys. Res. Commun. 266, 624–632 (1999).",{"doi":6644},"10.1006\u002Fbbrc.1999.1879",{"id":28,"text":6646,"url":28,"identifiers":6647},"Guerini, D., Wang, X., Li, L., Genazzani, A. & Carafoli, E. Calcineurin controls the expression of isoforms 4CII of the plasma membrane Ca2+ pump in neurons. J. Biol. Chem. 275, 3706–3712 (2000).",{"doi":6648},"10.1074\u002Fjbc.275.5.3706",{"id":28,"text":6650,"url":28,"identifiers":6651},"Li, L., Guerini, D. & Carafoli, E. Calcineurin controls the transcription of Na+\u002FCa2+ exchanger isoforms in developing cerebellar neurons. J. Biol. Chem. 275, 20903–20910 (2000).",{"doi":6652},"10.1074\u002Fjbc.M000995200",{"id":28,"text":6654,"url":28,"identifiers":6655},"Genazzani, A. A., Carafoli, E. & Guerini, D. Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. Proc. Natl Acad. Sci. USA 96, 5797–5801 (1999).",{"doi":6656},"10.1073\u002Fpnas.96.10.5797",{"id":28,"text":6658,"url":28,"identifiers":6659},"Graef, I. A. et al. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 401, 703–708 (1999). This paper and reference 97 have shown that Ca2+ can regulate the transcription of some of its signalling components, such as Ins(1,4,5)P 3 Rs.",{"doi":6660},"10.1038\u002F44378",{"id":28,"text":6662,"url":28,"identifiers":6663},"Brini, M., Bano, D., Manni, S., Rizzuto, R. & Carafoli, E. Effects of PMCA and SERCA pump overexpression on the kinetics of cell Ca2+ signalling. EMBO J. 19, 4926–4935 (2000).",{"doi":6664},"10.1093\u002Femboj\u002F19.18.4926",{"id":28,"text":6666,"url":28,"identifiers":6667},"Ji, Y. et al. Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function. J. Biol. Chem. 275, 38073–38080 (2000).",{"doi":6668},"10.1074\u002Fjbc.M004804200",{"id":28,"text":6670,"url":28,"identifiers":6671},"Zhao, X. -S., Shin, D. M., Liu, L. H., Shull, G. E. & Muallem, S. Plasticity and adaptation of Ca2+ signalling and Ca2+-dependent exocytosis in SERCA2+\u002F− mice. EMBO J. 20, 2680–2689 (2001).",{"doi":6672},"10.1093\u002Femboj\u002F20.11.2680",{"id":28,"text":6674,"url":28,"identifiers":6675},"Song, L. -S. et al. Ca2+ signaling in cardiac myocytes overexpressing the α1 subunit of L-type Ca2+ channel. Circ. Res. 90, 174–181 (2002).",{"doi":6676},"10.1161\u002Fhh0202.103230",{"id":28,"text":6678,"url":28,"identifiers":6679},"Molkentin, J. D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215–228 (1998).",{"doi":6680},"10.1016\u002FS0092-8674(00)81573-1",{"id":28,"text":6682,"url":28,"identifiers":6683},"Kirchhefer, U. et al. Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1. J. Biol. Chem. 276, 4142–4149 (2001).",{"doi":6684},"10.1074\u002Fjbc.M006443200",{"id":28,"text":6686,"url":28,"identifiers":6687},"Zhang, L., Franzini-Armstrong, C., Ramesh, V. & Jones, L. R. Structural alterations in cardiac calcium release units resulting from overexpression of junctin. J. Mol. Cell. Cardiol. 33, 233–247 (2001).",{"doi":6688},"10.1006\u002Fjmcc.2000.1295",{"id":28,"text":6690,"url":28,"identifiers":6691},"Jones, L. R. et al. Regulation of calcium signalling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J. Clin. Invest. 101, 1385–1393 (1998).",{"doi":6692},"10.1172\u002FJCI1362",{"id":28,"text":6694,"url":28,"identifiers":6695},"Mende, U. et al. Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc. Natl Acad. Sci. USA 95, 13893–13898 (1998).",{"doi":6696},"10.1073\u002Fpnas.95.23.13893",{"id":28,"text":6698,"url":28,"identifiers":6699},"Knollmann, B. C., Knollmann-Ritschel, B. E., Weissman, N. J., Jones, L. R. & Morad, M. Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J. Physiol. (Lond.) 525, 483–498 (2000).",{"doi":6700},"10.1111\u002Fj.1469-7793.2000.t01-1-00483.x",{"id":28,"text":6702,"url":28,"identifiers":6703},"Wettschureck, N. et al. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq\u002F Gα11 in cardiomyocytes. Nature Med. 7, 1236–1240 (2001). This paper provides direct evidence that receptors that are coupled to G qα \u002FG 11α function in cardiac hypertrophy.",{"doi":6704},"10.1038\u002Fnm1101-1236",{"id":28,"text":6706,"url":28,"identifiers":6707},"Antos, C. L. et al. Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo. Proc. Natl Acad. Sci. USA 99, 907–912 (2002).",{"doi":6708},"10.1073\u002Fpnas.231619298",{"id":28,"text":6710,"url":28,"identifiers":6711},"Sato, Y. et al. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. J. Biol. Chem. 276, 9392–9399 (2001).",{"doi":6712},"10.1074\u002Fjbc.M006889200",{"id":28,"text":6714,"url":28,"identifiers":6715},"Song, Q. et al. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J. Clin. Invest. 111, 859–867 (2003).",{"doi":6716},"10.1172\u002FJCI200316738",{"id":28,"text":6718,"url":28,"identifiers":6719},"Haghighi, K. et al. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J. Clin. Invest. 111, 869–876 (2003).",{"doi":6720},"10.1172\u002FJCI17892",{"id":28,"text":6722,"url":28,"identifiers":6723},"Wilkins, B. J. & Molkentin, J. D. Calcineurin and cardiac hypertrophy: where have we been? where are we going? J. Physiol. 541, 1–8 (2002).",{"doi":6724},"10.1113\u002Fjphysiol.2002.017129",{"id":28,"text":6726,"url":28,"identifiers":6727},"Xin, H. -B. et al. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature 416, 334–337 (2002).",{"doi":6728},"10.1038\u002F416334a",{"id":28,"text":6730,"url":28,"identifiers":6731},"Schwinger et al. Reduced Ca2+-sensitivity of SERCA2a in failing human myocardium due to reduced serine-16 phospholamban phosphorylation. J. Mol. Cell. Cardiol. 31, 479–491 (1999).",{"doi":6732},"10.1006\u002Fjmcc.1998.0897",{"id":28,"text":6734,"url":28,"identifiers":6735},"Piacentino III, V. et al. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ. Res. 92, 651–658 (2003).",{"doi":6736},"10.1161\u002F01.RES.0000062469.83985.9B",{"id":28,"text":6738,"url":28,"identifiers":6739},"Naga Prasad, S. V., Nienaber, J. & Rockman, H. A. β-adrenergic axis and heart disease. Trends Genet. 17, S44–S49 (2001).",{"doi":6740},"10.1016\u002FS0168-9525(01)02487-8",{"id":6742,"createTime":6743,"updateTime":6743,"relativeEntities":6744,"slug":6745,"properties":6746,"entityType":971,"verifyStatus":26,"verifyTime":6757,"verifyNote":972,"languages":6758,"translateLanguages":28,"viewCount":32,"primaryUrl":6759,"fullTextUrl":28,"authors":6760,"publicationType":1063,"publisherRelationship":6797,"citationCount":6850,"citationInfo":6851,"publishDate":6862,"publishYear":1848,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":6863,"openAccess":28,"references":6864,"isForceReanalyzing":1713},"c96b4c1e-300d-4f7f-9639-73db2769f3cb","2024-09-17T23:56:56.424+00:00",[],"Regulation-of-microRNA-biogenesis",{"openalex":6747,"mag":6749,"title":6751,"pm":6753,"doi":6755},{"VOID":6748},"W2006247279",{"VOID":6750},"2006247279",{"EN":6752},"Regulation of microRNA biogenesis",{"VOID":6754},"25027649",{"VOID":6756},"10.1038\u002Fnrm3838","2024-09-17T23:56:56.423+00:00",[31],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnrm3838",[6761,6780],{"id":6762,"sortIndex":32,"researcher":28,"roles":6763,"affiliations":6764,"properties":6773,"displayName":6777,"givenName":28,"familyName":28},"3bd7adc8-acb3-4751-9b46-8884488e0f35",[],[6765],{"id":6766,"sortIndex":32,"affiliation":6767,"properties":28},"a2fcfcd4-7946-48b5-9528-e1c22d342432",{"id":6766,"createTime":28,"updateTime":28,"relativeEntities":6768,"slug":28,"properties":6769,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6772,"statistic":28},[],{"title":6770},{"EN":6771},"Center for RNA Research, Institute for Basic Science (IBS), Seoul, 151–742, Korea",[],{"orcid":6774,"title":6776,"openalex":6778},{"VOID":6775},"https:\u002F\u002Forcid.org\u002F0000-0003-2328-415X",{"EN":6777},"Minju Ha",{"VOID":6779},"A5070461553",{"id":6781,"sortIndex":40,"researcher":28,"roles":6782,"affiliations":6783,"properties":6790,"displayName":6794,"givenName":28,"familyName":28},"f7d5fc61-74c7-4e2a-812b-19e41e12a0eb",[],[6784],{"id":6766,"sortIndex":32,"affiliation":6785,"properties":28},{"id":6766,"createTime":28,"updateTime":28,"relativeEntities":6786,"slug":28,"properties":6787,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6789,"statistic":28},[],{"title":6788},{"EN":6771},[],{"orcid":6791,"title":6793,"openalex":6795},{"VOID":6792},"https:\u002F\u002Forcid.org\u002F0000-0002-3213-4965",{"EN":6794},"V. 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D. Small silencing RNAs: an expanding universe. Nature Rev. Genet. 10, 94–108 (2009).",{"doi":6868},"10.1038\u002Fnrg2504",{"id":28,"text":6870,"url":28,"identifiers":6871},"Ishizu, H., Siomi, H. & Siomi, M. C. Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines. Genes Dev. 26, 2361–2373 (2012).",{"doi":6872},"10.1101\u002Fgad.203786.112",{"id":28,"text":6874,"url":28,"identifiers":6875},"Huntzinger, E. & Izaurralde, E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nature Rev. Genet. 12, 99–110 (2011).",{"doi":6876},"10.1038\u002Fnrg2936",{"id":28,"text":6878,"url":28,"identifiers":6879},"Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215–233 (2009).",{"doi":6880},"10.1016\u002Fj.cell.2009.01.002",{"id":28,"text":6882,"url":28,"identifiers":6883},"Friedman, R. C., Farh, K. K., Burge, C. B. & Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19, 92–105 (2009).",{"doi":6884},"10.1101\u002Fgr.082701.108",{"id":28,"text":6886,"url":28,"identifiers":6887},"Lujambio, A. & Lowe, S. W. The microcosmos of cancer. Nature 482, 347–355 (2012).",{"doi":6888},"10.1038\u002Fnature10888",{"id":28,"text":6890,"url":28,"identifiers":6891},"Im, H. I. & Kenny, P. J. MicroRNAs in neuronal function and dysfunction. Trends Neurosci. 35, 325–334 (2012).",{"doi":6892},"10.1016\u002Fj.tins.2012.01.004",{"id":28,"text":6894,"url":28,"identifiers":6895},"Kim, V. N., Han, J. & Siomi, M. C. Biogenesis of small RNAs in animals. Nature Rev. Mol. Cell Biol. 10, 126–139 (2009).",{"doi":6896},"10.1038\u002Fnrm2632",{"id":28,"text":6898,"url":28,"identifiers":6899},"Krol, J., Loedige, I. & Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nature Rev. Genet. 11, 597–610 (2010).",{"doi":6900},"10.1038\u002Fnrg2843",{"id":28,"text":6902,"url":28,"identifiers":6903},"Siomi, H. & Siomi, M. C. Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell 38, 323–332 (2010).",{"doi":6904},"10.1016\u002Fj.molcel.2010.03.013",{"id":28,"text":6906,"url":28,"identifiers":6907},"Axtell, M. J., Westholm, J. O. & Lai, E. C. Vive la difference: biogenesis and evolution of microRNAs in plants and animals. Genome Biol. 12, 221 (2011).",{"doi":6908},"10.1186\u002Fgb-2011-12-4-221",{"id":28,"text":6910,"url":28,"identifiers":6911},"Cuperus, J. T., Fahlgren, N. & Carrington, J. C. Evolution and functional diversification of miRNA genes. Plant Cell 23, 431–442 (2011).",{"doi":6912},"10.1105\u002Ftpc.110.082784",{"id":28,"text":6914,"url":28,"identifiers":6915},"Voinnet, O. Origin, biogenesis, and activity of plant microRNAs. Cell 136, 669–687 (2009).",{"doi":6916},"10.1016\u002Fj.cell.2009.01.046",{"id":28,"text":6918,"url":28,"identifiers":6919},"Chang, S. S., Zhang, Z. & Liu, Y. RNA interference pathways in fungi: mechanisms and functions. Annu. Rev. Microbiol. 66, 305–323 (2012).",{"doi":6920},"10.1146\u002Fannurev-micro-092611-150138",{"id":28,"text":6922,"url":28,"identifiers":6923},"Griffiths-Jones, S., Saini, H. K., van Dongen, S. & Enright, A. J. miRBase: tools for microRNA genomics. Nucleic Acids Res. 36, D154–D158 (2008).",{"doi":6924},"10.1093\u002Fnar\u002Fgkm952",{"id":28,"text":6926,"url":28,"identifiers":6927},"Chiang, H. R. et al. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 24, 992–1009 (2010).",{"doi":6928},"10.1101\u002Fgad.1884710",{"id":28,"text":6930,"url":28,"identifiers":6931},"Kozomara, A. & Griffiths-Jones, S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res 42, D68–D73 (2014).",{"doi":6932},"10.1093\u002Fnar\u002Fgkt1181",{"id":28,"text":6934,"url":28,"identifiers":6935},"Hertel, J. et al. The expansion of the metazoan microRNA repertoire. BMC Genomics 7, 25 (2006).",{"doi":6936},"10.1186\u002F1471-2164-7-25",{"id":28,"text":6938,"url":28,"identifiers":6939},"Berezikov, E. Evolution of microRNA diversity and regulation in animals. Nature Rev. Genet. 12, 846–860 (2011).",{"doi":6940},"10.1038\u002Fnrg3079",{"id":28,"text":6942,"url":28,"identifiers":6943},"Wheeler, B. M. et al. The deep evolution of metazoan microRNAs. Evol. Dev. 11, 50–68 (2009).",{"doi":6944},"10.1111\u002Fj.1525-142X.2008.00302.x",{"id":28,"text":6946,"url":28,"identifiers":6947},"Ventura, A. et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132, 875–886 (2008).",{"doi":6948},"10.1016\u002Fj.cell.2008.02.019",{"id":28,"text":6950,"url":28,"identifiers":6951},"Kim, Y. K. et al. TALEN-based knockout library for human microRNAs. Nature Struct. Mol. Biol. 20, 1458–1464 (2013).",{"doi":6952},"10.1038\u002Fnsmb.2701",{"id":28,"text":6954,"url":28,"identifiers":6955},"Lee, Y., Jeon, K., Lee, J. T., Kim, S. & Kim, V. N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21, 4663–4670 (2002).",{"doi":6956},"10.1093\u002Femboj\u002Fcdf476",{"id":28,"text":6958,"url":28,"identifiers":6959},"Roush, S. & Slack, F. J. The let-7 family of microRNAs. Trends Cell Biol. 18, 505–516 (2008).",{"doi":6960},"10.1016\u002Fj.tcb.2008.07.007",{"id":28,"text":6962,"url":28,"identifiers":6963},"Ozsolak, F. et al. Chromatin structure analyses identify miRNA promoters. Genes Dev. 22, 3172–3183 (2008).",{"doi":6964},"10.1101\u002Fgad.1706508",{"id":28,"text":6966,"url":28,"identifiers":6967},"Monteys, A. M. et al. Structure and activity of putative intronic miRNA promoters. RNA 16, 495–505 (2010).",{"doi":6968},"10.1261\u002Frna.1731910",{"id":28,"text":6970,"url":28,"identifiers":6971},"Cai, X., Hagedorn, C. H. & Cullen, B. R. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10, 1957–1966 (2004).",{"doi":6972},"10.1261\u002Frna.7135204",{"id":28,"text":6974,"url":28,"identifiers":6975},"Lee, Y. et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23, 4051–4060 (2004).",{"doi":6976},"10.1038\u002Fsj.emboj.7600385",{"id":28,"text":6978,"url":28,"identifiers":6979},"Pfeffer, S. et al. Identification of microRNAs of the herpesvirus family. Nature Methods 2, 269–276 (2005).",{"doi":6980},"10.1038\u002Fnmeth746",{"id":28,"text":6982,"url":28,"identifiers":6983},"Babiarz, J. E., Ruby, J. G., Wang, Y., Bartel, D. P. & Blelloch, R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev. 22, 2773–2785 (2008).",{"doi":6984},"10.1101\u002Fgad.1705308",{"id":28,"text":6986,"url":28,"identifiers":6987},"Davis-Dusenbery, B. N. & Hata, A. Mechanisms of control of microRNA biogenesis. J. Biochem. 148, 381–392 (2010).",{},{"id":28,"text":6989,"url":28,"identifiers":6990},"Lee, Y. et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415–419 (2003).",{"doi":6991},"10.1038\u002Fnature01957",{"id":28,"text":6993,"url":28,"identifiers":6994},"Denli, A. M., Tops, B. B., Plasterk, R. H., Ketting, R. F. & Hannon, G. J. Processing of primary microRNAs by the Microprocessor complex. Nature 432, 231–235 (2004).",{"doi":6995},"10.1038\u002Fnature03049",{"id":28,"text":6997,"url":28,"identifiers":6998},"Gregory, R. I. et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235–240 (2004).",{"doi":6999},"10.1038\u002Fnature03120",{"id":28,"text":7001,"url":28,"identifiers":7002},"Han, J. et al. The Drosha–DGCR8 complex in primary microRNA processing. Genes Dev. 18, 3016–3027 (2004).",{"doi":7003},"10.1101\u002Fgad.1262504",{"id":28,"text":7005,"url":28,"identifiers":7006},"Landthaler, M., Yalcin, A. & Tuschl, T. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. Curr. Biol. 14, 2162–2167 (2004).",{"doi":7007},"10.1016\u002Fj.cub.2004.11.001",{"id":28,"text":7009,"url":28,"identifiers":7010},"Chong, M. M. et al. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev. 24, 1951–1960 (2010).",{"doi":7011},"10.1101\u002Fgad.1953310",{"id":28,"text":7013,"url":28,"identifiers":7014},"Wang, Y., Medvid, R., Melton, C., Jaenisch, R. & Blelloch, R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nature Genet. 39, 380–385 (2007).",{"doi":7015},"10.1038\u002Fng1969",{"id":28,"text":7017,"url":28,"identifiers":7018},"Shiohama, A., Sasaki, T., Noda, S., Minoshima, S. & Shimizu, N. Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region. Biochem. Biophys. Res. Commun. 304, 184–190 (2003).",{"doi":7019},"10.1016\u002FS0006-291X(03)00554-0",{"id":28,"text":7021,"url":28,"identifiers":7022},"Goldberg, R., Motzkin, B., Marion, R., Scambler, P. J. & Shprintzen, R. J. Velo-cardio-facial syndrome: a review of 120 patients. Am. J. Med. Genet. 45, 313–319 (1993).",{"doi":7023},"10.1002\u002Fajmg.1320450307",{"id":28,"text":7025,"url":28,"identifiers":7026},"Filippov, V., Solovyev, V., Filippova, M. & Gill, S. S. A novel type of RNase III family proteins in eukaryotes. Gene 245, 213–221 (2000).",{"doi":7027},"10.1016\u002FS0378-1119(99)00571-5",{"id":28,"text":7029,"url":28,"identifiers":7030},"Fortin, K. R., Nicholson, R. H. & Nicholson, A. W. Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location. BMC Genomics 3, 26 (2002).",{"doi":7031},"10.1186\u002F1471-2164-3-26",{"id":28,"text":7033,"url":28,"identifiers":7034},"Wu, H., Xu, H., Miraglia, L. J. & Crooke, S. T. Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. J. Biol. Chem. 275, 36957–36965 (2000).",{"doi":7035},"10.1074\u002Fjbc.M005494200",{"id":28,"text":7037,"url":28,"identifiers":7038},"Tang, X., Zhang, Y., Tucker, L. & Ramratnam, B. Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization. Nucleic Acids Res. 38, 6610–6619 (2010).",{"doi":7039},"10.1093\u002Fnar\u002Fgkq547",{"id":28,"text":7041,"url":28,"identifiers":7042},"Blaszczyk, J. et al. Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage. Structure 9, 1225–1236 (2001).",{"doi":7043},"10.1016\u002FS0969-2126(01)00685-2",{"id":28,"text":7045,"url":28,"identifiers":7046},"Zhang, H., Kolb, F. A., Jaskiewicz, L., Westhof, E. & Filipowicz, W. Single processing center models for human Dicer and bacterial RNase III. Cell 118, 57–68 (2004).",{"doi":7047},"10.1016\u002Fj.cell.2004.06.017",{"id":28,"text":7049,"url":28,"identifiers":7050},"Shiohama, A., Sasaki, T., Noda, S., Minoshima, S. & Shimizu, N. Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. Exp. Cell Res. 313, 4196–4207 (2007).",{"doi":7051},"10.1016\u002Fj.yexcr.2007.07.020",{"id":28,"text":7053,"url":28,"identifiers":7054},"Yeom, K. H., Lee, Y., Han, J., Suh, M. R. & Kim, V. N. Characterization of DGCR8\u002FPasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res. 34, 4622–4629 (2006).",{"doi":7055},"10.1093\u002Fnar\u002Fgkl458",{"id":28,"text":7057,"url":28,"identifiers":7058},"Han, J. et al. Molecular basis for the recognition of primary microRNAs by the Drosha–DGCR8 complex. Cell 125, 887–901 (2006).",{"doi":7059},"10.1016\u002Fj.cell.2006.03.043",{"id":28,"text":7061,"url":28,"identifiers":7062},"Sohn, S. Y. et al. Crystal structure of human DGCR8 core. Nature Struct. Mol. Biol. 14, 847–853 (2007).",{"doi":7063},"10.1038\u002Fnsmb1294",{"id":28,"text":7065,"url":28,"identifiers":7066},"Faller, M., Matsunaga, M., Yin, S., Loo, J. A. & Guo, F. Heme is involved in microRNA processing. Nature Struct. Mol. Biol. 14, 23–29 (2007).",{"doi":7067},"10.1038\u002Fnsmb1182",{"id":28,"text":7069,"url":28,"identifiers":7070},"Faller, M. et al. DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA 16, 1570–1583 (2010).",{"doi":7071},"10.1261\u002Frna.2111310",{"id":28,"text":7073,"url":28,"identifiers":7074},"Barr, I. et al. Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc. Natl Acad. Sci. USA 109, 1919–1924 (2012).",{"doi":7075},"10.1073\u002Fpnas.1114514109",{"id":28,"text":7077,"url":28,"identifiers":7078},"Weitz, S. H., Gong, M., Barr, I., Weiss, S. & Guo, F. Processing of microRNA primary transcripts requires heme in mammalian cells. Proc. Natl Acad. Sci. USA 111, 1861–1866 (2014).",{"doi":7079},"10.1073\u002Fpnas.1309915111",{"id":28,"text":7081,"url":28,"identifiers":7082},"Zeng, Y., Yi, R. & Cullen, B. R. Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J. 24, 138–148 (2005).",{"doi":7083},"10.1038\u002Fsj.emboj.7600491",{"id":28,"text":7085,"url":28,"identifiers":7086},"Auyeung, V. C., Ulitsky, I., McGeary, S. E. & Bartel, D. P. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell 152, 844–858 (2013).",{"doi":7087},"10.1016\u002Fj.cell.2013.01.031",{"id":28,"text":7089,"url":28,"identifiers":7090},"Ma, H., Wu, Y., Choi, J. G. & Wu, H. Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site. Proc. Natl Acad. Sci. USA 110, 20687–20692 (2013).",{"doi":7091},"10.1073\u002Fpnas.1311639110",{"id":28,"text":7093,"url":28,"identifiers":7094},"Mori, M. et al. Hippo signaling regulates Microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell 156, 893–906 (2014).",{"doi":7095},"10.1016\u002Fj.cell.2013.12.043",{"id":28,"text":7097,"url":28,"identifiers":7098},"Kim, Y. K. & Kim, V. N. Processing of intronic microRNAs. EMBO J. 26, 775–783 (2007).",{"doi":7099},"10.1038\u002Fsj.emboj.7601512",{"id":28,"text":7101,"url":28,"identifiers":7102},"Morlando, M. et al. Primary microRNA transcripts are processed co-transcriptionally. Nature Struct. Mol. Biol. 15, 902–909 (2008).",{"doi":7103},"10.1038\u002Fnsmb.1475",{"id":28,"text":7105,"url":28,"identifiers":7106},"Pawlicki, J. M. & Steitz, J. A. Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production. J. Cell Biol. 182, 61–76 (2008).",{"doi":7107},"10.1083\u002Fjcb.200803111",{"id":28,"text":7109,"url":28,"identifiers":7110},"Han, J. et al. Posttranscriptional crossregulation between Drosha and DGCR8. Cell 136, 75–84 (2009).",{"doi":7111},"10.1016\u002Fj.cell.2008.10.053",{"id":28,"text":7113,"url":28,"identifiers":7114},"Sundaram, G. M. et al. 'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing. Nature 495, 103–106 (2013).",{"doi":7115},"10.1038\u002Fnature11890",{"id":28,"text":7117,"url":28,"identifiers":7118},"Knuckles, P. et al. Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs. Nature Neurosci. 15, 962–969 (2012).",{"doi":7119},"10.1038\u002Fnn.3139",{"id":28,"text":7121,"url":28,"identifiers":7122},"Kadener, S. et al. Genome-wide identification of targets of the drosha-pasha\u002FDGCR8 complex. RNA 15, 537–545 (2009).",{"doi":7123},"10.1261\u002Frna.1319309",{"id":28,"text":7125,"url":28,"identifiers":7126},"Herbert, K. M., Pimienta, G., DeGregorio, S. J., Alexandrov, A. & Steitz, J. A. Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile. Cell Rep. 5, 1070–1081 (2013).",{"doi":7127},"10.1016\u002Fj.celrep.2013.10.017",{"id":28,"text":7129,"url":28,"identifiers":7130},"Tang, X., Li, M., Tucker, L. & Ramratnam, B. Glycogen synthase kinase 3 beta (GSK3β) phosphorylates the RNAase III enzyme Drosha at S300 and S302. PLoS ONE 6, e20391 (2011).",{"doi":7131},"10.1371\u002Fjournal.pone.0020391",{"id":28,"text":7133,"url":28,"identifiers":7134},"Wada, T., Kikuchi, J. & Furukawa, Y. Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8. EMBO Rep. 13, 142–149 (2012).",{"doi":7135},"10.1038\u002Fembor.2011.247",{"id":28,"text":7137,"url":28,"identifiers":7138},"Tang, X. et al. Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination. PLoS ONE 8, e72503 (2013).",{"doi":7139},"10.1371\u002Fjournal.pone.0072503",{"id":28,"text":7141,"url":28,"identifiers":7142},"Cheng, T. L. et al. MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8\u002FDrosha complex. Dev. Cell 28, 547–560 (2014).",{"doi":7143},"10.1016\u002Fj.devcel.2014.01.032",{"id":28,"text":7145,"url":28,"identifiers":7146},"Fukuda, T. et al. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nature Cell Biol. 9, 604–611 (2007).",{"doi":7147},"10.1038\u002Fncb1577",{"id":28,"text":7149,"url":28,"identifiers":7150},"Davis, B. N., Hilyard, A. C., Lagna, G. & Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454, 56–61 (2008).",{"doi":7151},"10.1038\u002Fnature07086",{"id":28,"text":7153,"url":28,"identifiers":7154},"Davis, B. N., Hilyard, A. C., Nguyen, P. H., Lagna, G. & Hata, A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol. Cell 39, 373–384 (2010).",{"doi":7155},"10.1016\u002Fj.molcel.2010.07.011",{"id":28,"text":7157,"url":28,"identifiers":7158},"Suzuki, H. I. et al. Modulation of microRNA processing by p53. Nature 460, 529–533 (2009).",{"doi":7159},"10.1038\u002Fnature08199",{"id":28,"text":7161,"url":28,"identifiers":7162},"Di Carlo, V. et al. TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation. Mol. Neurobiol. 48, 952–963 (2013).",{"doi":7163},"10.1007\u002Fs12035-013-8564-x",{"id":28,"text":7165,"url":28,"identifiers":7166},"Kawahara, Y. & Mieda-Sato, A. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proc. Natl Acad. Sci. USA 109, 3347–3352 (2012).",{"doi":7167},"10.1073\u002Fpnas.1112427109",{"id":28,"text":7169,"url":28,"identifiers":7170},"Guil, S. & Caceres, J. F. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nature Struct. Mol. Biol. 14, 591–596 (2007).",{"doi":7171},"10.1038\u002Fnsmb1250",{"id":28,"text":7173,"url":28,"identifiers":7174},"Michlewski, G., Guil, S., Semple, C. A. & Caceres, J. F. Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol. Cell 32, 383–393 (2008).",{"doi":7175},"10.1016\u002Fj.molcel.2008.10.013",{"id":28,"text":7177,"url":28,"identifiers":7178},"Trabucchi, M. et al. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459, 1010–1014 (2009).",{"doi":7179},"10.1038\u002Fnature08025",{"id":28,"text":7181,"url":28,"identifiers":7182},"Bohnsack, M. T. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185–191 (2004).",{"doi":7183},"10.1261\u002Frna.5167604",{"id":28,"text":7185,"url":28,"identifiers":7186},"Lund, E., Guttinger, S., Calado, A., Dahlberg, J. E. & Kutay, U. Nuclear export of microRNA precursors. Science 303, 95–98 (2004).",{"doi":7187},"10.1126\u002Fscience.1090599",{"id":28,"text":7189,"url":28,"identifiers":7190},"Yi, R., Qin, Y., Macara, I. G. & Cullen, B. R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011–3016 (2003).",{"doi":7191},"10.1101\u002Fgad.1158803",{"id":28,"text":7193,"url":28,"identifiers":7194},"Okada, C. et al. A high-resolution structure of the pre-microRNA nuclear export machinery. Science 326, 1275–1279 (2009).",{"doi":7195},"10.1126\u002Fscience.1178705",{"id":28,"text":7197,"url":28,"identifiers":7198},"Gwizdek, C. et al. Exportin-5 mediates nuclear export of minihelix-containing RNAs. J. Biol. Chem. 278, 5505–5508 (2003).",{"doi":7199},"10.1074\u002Fjbc.C200668200",{"id":28,"text":7201,"url":28,"identifiers":7202},"Zeng, Y. & Cullen, B. R. Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res. 32, 4776–4785 (2004).",{"doi":7203},"10.1093\u002Fnar\u002Fgkh824",{"id":28,"text":7205,"url":28,"identifiers":7206},"Iwasaki, Y. W. et al. Global microRNA elevation by inducible Exportin 5 regulates cell cycle entry. RNA 19, 490–497 (2013).",{"doi":7207},"10.1261\u002Frna.036608.112",{"id":28,"text":7209,"url":28,"identifiers":7210},"Wan, G. et al. DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM–AKT pathway. Cell Rep. 3, 2100–2112 (2013).",{"doi":7211},"10.1016\u002Fj.celrep.2013.05.038",{"id":28,"text":7213,"url":28,"identifiers":7214},"Melo, S. A. et al. A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18, 303–315 (2010).",{"doi":7215},"10.1016\u002Fj.ccr.2010.09.007",{"id":28,"text":7217,"url":28,"identifiers":7218},"Xie, M. et al. Mammalian 5′-capped microRNA precursors that generate a single microRNA. Cell 155, 1568–1580 (2013).",{"doi":7219},"10.1016\u002Fj.cell.2013.11.027",{"id":28,"text":7221,"url":28,"identifiers":7222},"Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363–366 (2001).",{"doi":7223},"10.1038\u002F35053110",{"id":28,"text":7225,"url":28,"identifiers":7226},"Grishok, A. et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23–34 (2001).",{"doi":7227},"10.1016\u002FS0092-8674(01)00431-7",{"id":28,"text":7229,"url":28,"identifiers":7230},"Hutvagner, G. et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834–838 (2001).",{"doi":7231},"10.1126\u002Fscience.1062961",{"id":28,"text":7233,"url":28,"identifiers":7234},"Ketting, R. F. et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15, 2654–2659 (2001).",{"doi":7235},"10.1101\u002Fgad.927801",{"id":28,"text":7237,"url":28,"identifiers":7238},"Knight, S. W. & Bass, B. L. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293, 2269–2271 (2001).",{"doi":7239},"10.1126\u002Fscience.1062039",{"id":28,"text":7241,"url":28,"identifiers":7242},"Lee, Y. S. et al. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA\u002FmiRNA silencing pathways. Cell 117, 69–81 (2004).",{"doi":7243},"10.1016\u002FS0092-8674(04)00261-2",{"id":28,"text":7245,"url":28,"identifiers":7246},"Xie, Z. et al. Genetic and functional diversification of small RNA pathways in plants. PLoS Biol. 2, E104 (2004).",{"doi":7247},"10.1371\u002Fjournal.pbio.0020104",{"id":28,"text":7249,"url":28,"identifiers":7250},"Bernstein, E. et al. Dicer is essential for mouse development. Nature Genet. 35, 215–217 (2003).",{"doi":7251},"10.1038\u002Fng1253",{"id":28,"text":7253,"url":28,"identifiers":7254},"Kanellopoulou, C. et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 19, 489–501 (2005).",{"doi":7255},"10.1101\u002Fgad.1248505",{"id":28,"text":7257,"url":28,"identifiers":7258},"Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S. & Hannon, G. J. Characterization of Dicer-deficient murine embryonic stem cells. Proc. Natl Acad. Sci. USA 102, 12135–12140 (2005).",{"doi":7259},"10.1073\u002Fpnas.0505479102",{"id":28,"text":7261,"url":28,"identifiers":7262},"Yang, J. S. & Lai, E. C. Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol. Cell 43, 892–903 (2011).",{"doi":7263},"10.1016\u002Fj.molcel.2011.07.024",{"id":28,"text":7265,"url":28,"identifiers":7266},"Kumar, M. S. et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 23, 2700–2704 (2009).",{"doi":7267},"10.1101\u002Fgad.1848209",{"id":28,"text":7269,"url":28,"identifiers":7270},"Tsutsumi, A., Kawamata, T., Izumi, N., Seitz, H. & Tomari, Y. Recognition of the pre-miRNA structure by Drosophila Dicer-1. Nature Struct. Mol. Biol. 18, 1153–1158 (2011).",{"doi":7271},"10.1038\u002Fnsmb.2125",{"id":28,"text":7273,"url":28,"identifiers":7274},"Gu, S. et al. The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell 151, 900–911 (2012).",{"doi":7275},"10.1016\u002Fj.cell.2012.09.042",{"id":28,"text":7277,"url":28,"identifiers":7278},"Macrae, I. J. et al. Structural basis for double-stranded RNA processing by Dicer. Science 311, 195–198 (2006).",{"doi":7279},"10.1126\u002Fscience.1121638",{"id":28,"text":7281,"url":28,"identifiers":7282},"Park, J. E. et al. Dicer recognizes the 5′ end of RNA for efficient and accurate processing. Nature 475, 201–205 (2011).",{"doi":7283},"10.1038\u002Fnature10198",{"id":28,"text":7285,"url":28,"identifiers":7286},"Tian, Y. et al. A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer. Mol. Cell 53, 606–616 (2014).",{"doi":7287},"10.1016\u002Fj.molcel.2014.01.003",{"id":28,"text":7289,"url":28,"identifiers":7290},"Lau, P. W., Potter, C. S., Carragher, B. & MacRae, I. J. Structure of the human Dicer–TRBP complex by electron microscopy. Structure 17, 1326–1332 (2009).",{"doi":7291},"10.1016\u002Fj.str.2009.08.013",{"id":28,"text":7293,"url":28,"identifiers":7294},"Taylor, D. W. et al. Substrate-specific structural rearrangements of human Dicer. Nature Struct. Mol. Biol. 20, 662–670 (2013).",{"doi":7295},"10.1038\u002Fnsmb.2564",{"id":28,"text":7297,"url":28,"identifiers":7298},"Wang, H. W. et al. Structural insights into RNA processing by the human RISC-loading complex. Nature Struct. Mol. Biol. 16, 1148–1153 (2009).",{"doi":7299},"10.1038\u002Fnsmb.1673",{"id":28,"text":7301,"url":28,"identifiers":7302},"MacRae, I. J., Zhou, K. & Doudna, J. A. Structural determinants of RNA recognition and cleavage by Dicer. Nature Struct. Mol. Biol. 14, 934–940 (2007).",{"doi":7303},"10.1038\u002Fnsmb1293",{"id":28,"text":7305,"url":28,"identifiers":7306},"Vermeulen, A. et al. The contributions of dsRNA structure to Dicer specificity and efficiency. RNA 11, 674–682 (2005).",{"doi":7307},"10.1261\u002Frna.7272305",{"id":28,"text":7309,"url":28,"identifiers":7310},"Zhang, H., Kolb, F. A., Brondani, V., Billy, E. & Filipowicz, W. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21, 5875–5885 (2002).",{"doi":7311},"10.1093\u002Femboj\u002Fcdf582",{"id":28,"text":7313,"url":28,"identifiers":7314},"Forstemann, K. et al. Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol. 3, e236 (2005).",{"doi":7315},"10.1371\u002Fjournal.pbio.0030236",{"id":28,"text":7317,"url":28,"identifiers":7318},"Jiang, F. et al. Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila. Genes Dev. 19, 1674–1679 (2005).",{"doi":7319},"10.1101\u002Fgad.1334005",{"id":28,"text":7321,"url":28,"identifiers":7322},"Saito, K., Ishizuka, A., Siomi, H. & Siomi, M. C. Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells. PLoS Biol. 3, e235 (2005).",{"doi":7323},"10.1371\u002Fjournal.pbio.0030235",{"id":28,"text":7325,"url":28,"identifiers":7326},"Fukunaga, R. et al. Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell 151, 533–546 (2012).",{"doi":7327},"10.1016\u002Fj.cell.2012.09.027",{"id":28,"text":7329,"url":28,"identifiers":7330},"Liu, X. et al. Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes. RNA 13, 2324–2329 (2007).",{"doi":7331},"10.1261\u002Frna.723707",{"id":28,"text":7333,"url":28,"identifiers":7334},"Park, J. K., Liu, X., Strauss, T. J., McKearin, D. M. & Liu, Q. The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells. Curr. Biol. 17, 533–538 (2007).",{"doi":7335},"10.1016\u002Fj.cub.2007.01.060",{"id":28,"text":7337,"url":28,"identifiers":7338},"Chendrimada, T. P. et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740–744 (2005).",{"doi":7339},"10.1038\u002Fnature03868",{"id":28,"text":7341,"url":28,"identifiers":7342},"Haase, A. D. et al. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep. 6, 961–967 (2005).",{"doi":7343},"10.1038\u002Fsj.embor.7400509",{"id":28,"text":7345,"url":28,"identifiers":7346},"Lee, Y. et al. The role of PACT in the RNA silencing pathway. EMBO J. 25, 522–532 (2006).",{"doi":7347},"10.1038\u002Fsj.emboj.7600942",{"id":28,"text":7349,"url":28,"identifiers":7350},"Lee, H. Y., Zhou, K., Smith, A. M., Noland, C. L. & Doudna, J. A. Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res. 41, 6568–6576 (2013).",{"doi":7351},"10.1093\u002Fnar\u002Fgkt361",{"id":28,"text":7353,"url":28,"identifiers":7354},"Chakravarthy, S., Sternberg, S. H., Kellenberger, C. A. & Doudna, J. A. Substrate-specific kinetics of Dicer-catalyzed RNA processing. J. Mol. Biol. 404, 392–402 (2010).",{"doi":7355},"10.1016\u002Fj.jmb.2010.09.030",{"id":28,"text":7357,"url":28,"identifiers":7358},"Lee, H. Y. & Doudna, J. A. TRBP alters human precursor microRNA processing in vitro. RNA 18, 2012–2019 (2012).",{"doi":7359},"10.1261\u002Frna.035501.112",{"id":28,"text":7361,"url":28,"identifiers":7362},"Garcia, M. A., Meurs, E. F. & Esteban, M. The dsRNA protein kinase PKR: virus and cell control. Biochimie 89, 799–811 (2007).",{"doi":7363},"10.1016\u002Fj.biochi.2007.03.001",{"id":28,"text":7365,"url":28,"identifiers":7366},"Paroo, Z., Ye, X., Chen, S. & Liu, Q. Phosphorylation of the human microRNA-generating complex mediates MAPK\u002FErk signaling. Cell 139, 112–122 (2009).",{"doi":7367},"10.1016\u002Fj.cell.2009.06.044",{"id":28,"text":7369,"url":28,"identifiers":7370},"Melo, S. A. et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nature Genet. 41, 365–370 (2009).",{"doi":7371},"10.1038\u002Fng.317",{"id":28,"text":7373,"url":28,"identifiers":7374},"Tokumaru, S., Suzuki, M., Yamada, H., Nagino, M. & Takahashi, T. let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis 29, 2073–2077 (2008).",{"doi":7375},"10.1093\u002Fcarcin\u002Fbgn187",{"id":28,"text":7377,"url":28,"identifiers":7378},"Forman, J. J., Legesse-Miller, A. & Coller, H. A. A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc. Natl Acad. Sci. USA 105, 14879–14884 (2008).",{"doi":7379},"10.1073\u002Fpnas.0803230105",{"id":28,"text":7381,"url":28,"identifiers":7382},"Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R. & Hannon, G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146–1150 (2001).",{"doi":7383},"10.1126\u002Fscience.1064023",{"id":28,"text":7385,"url":28,"identifiers":7386},"Mourelatos, Z. et al. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 16, 720–728 (2002).",{"doi":7387},"10.1101\u002Fgad.974702",{"id":28,"text":7389,"url":28,"identifiers":7390},"Tabara, H. et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99, 123–132 (1999).",{"doi":7391},"10.1016\u002FS0092-8674(00)81644-X",{"id":28,"text":7393,"url":28,"identifiers":7394},"Kawamata, T. & Tomari, Y. Making RISC. Trends Biochem. Sci. 35, 368–376 (2010).",{"doi":7395},"10.1016\u002Fj.tibs.2010.03.009",{"id":28,"text":7397,"url":28,"identifiers":7398},"Elkayam, E. et al. The structure of human Argonaute-2 in complex with miR-20a. Cell 150, 100–110 (2012).",{"doi":7399},"10.1016\u002Fj.cell.2012.05.017",{"id":28,"text":7401,"url":28,"identifiers":7402},"Nakanishi, K., Weinberg, D. E., Bartel, D. P. & Patel, D. J. Structure of yeast Argonaute with guide RNA. Nature 486, 368–374 (2012).",{"doi":7403},"10.1038\u002Fnature11211",{"id":28,"text":7405,"url":28,"identifiers":7406},"Schirle, N. T. & MacRae, I. J. The crystal structure of human Argonaute2. Science 336, 1037–1040 (2012).",{"doi":7407},"10.1126\u002Fscience.1221551",{"id":28,"text":7409,"url":28,"identifiers":7410},"Song, J. J., Smith, S. K., Hannon, G. J. & Joshua-Tor, L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305, 1434–1437 (2004).",{"doi":7411},"10.1126\u002Fscience.1102514",{"id":28,"text":7413,"url":28,"identifiers":7414},"Ma, J. B. et al. Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature 434, 666–670 (2005).",{"doi":7415},"10.1038\u002Fnature03514",{"id":28,"text":7417,"url":28,"identifiers":7418},"Parker, J. S., Roe, S. M. & Barford, D. Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature 434, 663–666 (2005).",{"doi":7419},"10.1038\u002Fnature03462",{"id":28,"text":7421,"url":28,"identifiers":7422},"Wang, Y., Sheng, G., Juranek, S., Tuschl, T. & Patel, D. J. Structure of the guide-strand-containing argonaute silencing complex. Nature 456, 209–213 (2008).",{"doi":7423},"10.1038\u002Fnature07315",{"id":28,"text":7425,"url":28,"identifiers":7426},"Frank, F., Sonenberg, N. & Nagar, B. Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2. Nature 465, 818–822 (2010).",{"doi":7427},"10.1038\u002Fnature09039",{"id":28,"text":7429,"url":28,"identifiers":7430},"Wang, Y. et al. Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature 456, 921–926 (2008).",{"doi":7431},"10.1038\u002Fnature07666",{"id":28,"text":7433,"url":28,"identifiers":7434},"Wang, Y. et al. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature 461, 754–761 (2009).",{"doi":7435},"10.1038\u002Fnature08434",{"id":28,"text":7437,"url":28,"identifiers":7438},"Liu, J. et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437–1441 (2004).",{"doi":7439},"10.1126\u002Fscience.1102513",{"id":28,"text":7441,"url":28,"identifiers":7442},"Cheloufi, S., Dos Santos, C. O., Chong, M. M. & Hannon, G. J. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465, 584–589 (2010).",{"doi":7443},"10.1038\u002Fnature09092",{"id":28,"text":7445,"url":28,"identifiers":7446},"Su, H., Trombly, M. I., Chen, J. & Wang, X. Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 23, 304–317 (2009).",{"doi":7447},"10.1101\u002Fgad.1749809",{"id":28,"text":7449,"url":28,"identifiers":7450},"Modzelewski, A. J., Holmes, R. J., Hilz, S., Grimson, A. & Cohen, P. E. AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Dev. Cell 23, 251–264 (2012).",{"doi":7451},"10.1016\u002Fj.devcel.2012.07.003",{"id":28,"text":7453,"url":28,"identifiers":7454},"Forstemann, K., Horwich, M. D., Wee, L., Tomari, Y. & Zamore, P. D. Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell 130, 287–297 (2007).",{"doi":7455},"10.1016\u002Fj.cell.2007.05.056",{"id":28,"text":7457,"url":28,"identifiers":7458},"Okamura, K., Ishizuka, A., Siomi, H. & Siomi, M. C. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18, 1655–1666 (2004).",{"doi":7459},"10.1101\u002Fgad.1210204",{"id":28,"text":7461,"url":28,"identifiers":7462},"Tomari, Y., Du, T. & Zamore, P. D. Sorting of Drosophila small silencing RNAs. Cell 130, 299–308 (2007).",{"doi":7463},"10.1016\u002Fj.cell.2007.05.057",{"id":28,"text":7465,"url":28,"identifiers":7466},"Czech, B. et al. Hierarchical rules for Argonaute loading in Drosophila. Mol. Cell 36, 445–456 (2009).",{"doi":7467},"10.1016\u002Fj.molcel.2009.09.028",{"id":28,"text":7469,"url":28,"identifiers":7470},"Ghildiyal, M., Xu, J., Seitz, H., Weng, Z. & Zamore, P. D. Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA 16, 43–56 (2010).",{"doi":7471},"10.1261\u002Frna.1972910",{"id":28,"text":7473,"url":28,"identifiers":7474},"Kawamata, T., Seitz, H. & Tomari, Y. Structural determinants of miRNAs for RISC loading and slicer-independent unwinding. Nature Struct. Mol. Biol. 16, 953–960 (2009).",{"doi":7475},"10.1038\u002Fnsmb.1630",{"id":28,"text":7477,"url":28,"identifiers":7478},"Okamura, K., Liu, N. & Lai, E. C. Distinct mechanisms for microRNA strand selection by Drosophila Argonautes. Mol. Cell 36, 431–444 (2009).",{"doi":7479},"10.1016\u002Fj.molcel.2009.09.027",{"id":28,"text":7481,"url":28,"identifiers":7482},"Jannot, G., Boisvert, M. E., Banville, I. H. & Simard, M. J. Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans. RNA 14, 829–835 (2008).",{"doi":7483},"10.1261\u002Frna.901908",{"id":28,"text":7485,"url":28,"identifiers":7486},"Steiner, F. A. et al. Structural features of small RNA precursors determine Argonaute loading in Caenorhabditis elegans. Nature Struct. Mol. Biol. 14, 927–933 (2007).",{"doi":7487},"10.1038\u002Fnsmb1308",{"id":28,"text":7489,"url":28,"identifiers":7490},"Azuma-Mukai, A. et al. Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. Proc. Natl Acad. Sci. USA 105, 7964–7969 (2008).",{"doi":7491},"10.1073\u002Fpnas.0800334105",{"id":28,"text":7493,"url":28,"identifiers":7494},"Meister, G. et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol. Cell 15, 185–197 (2004).",{"doi":7495},"10.1016\u002Fj.molcel.2004.07.007",{"id":28,"text":7497,"url":28,"identifiers":7498},"Dueck, A., Ziegler, C., Eichner, A., Berezikov, E. & Meister, G. microRNAs associated with the different human Argonaute proteins. Nucleic Acids Res. 40, 9850–9862 (2012).",{"doi":7499},"10.1093\u002Fnar\u002Fgks705",{"id":28,"text":7501,"url":28,"identifiers":7502},"Yoda, M. et al. ATP-dependent human RISC assembly pathways. Nature Struct. Mol. Biol. 17, 17–23 (2010).",{"doi":7503},"10.1038\u002Fnsmb.1733",{"id":28,"text":7505,"url":28,"identifiers":7506},"Liu, Y. et al. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 325, 750–753 (2009).",{"doi":7507},"10.1126\u002Fscience.1176325",{"id":28,"text":7509,"url":28,"identifiers":7510},"Pham, J. W., Pellino, J. L., Lee, Y. S., Carthew, R. W. & Sontheimer, E. J. A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell 117, 83–94 (2004).",{"doi":7511},"10.1016\u002FS0092-8674(04)00258-2",{"id":28,"text":7513,"url":28,"identifiers":7514},"Tomari, Y. et al. RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116, 831–841 (2004).",{"doi":7515},"10.1016\u002FS0092-8674(04)00218-1",{"id":28,"text":7517,"url":28,"identifiers":7518},"Gregory, R. I., Chendrimada, T. P., Cooch, N. & Shiekhattar, R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 123, 631–640 (2005).",{"doi":7519},"10.1016\u002Fj.cell.2005.10.022",{"id":28,"text":7521,"url":28,"identifiers":7522},"MacRae, I. J., Ma, E., Zhou, M., Robinson, C. V. & Doudna, J. A. In vitro reconstitution of the human RISC-loading complex. Proc. Natl Acad. Sci. USA 105, 512–517 (2008).",{"doi":7523},"10.1073\u002Fpnas.0710869105",{"id":28,"text":7525,"url":28,"identifiers":7526},"Maniataki, E. & Mourelatos, Z. A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 19, 2979–2990 (2005).",{"doi":7527},"10.1101\u002Fgad.1384005",{"id":28,"text":7529,"url":28,"identifiers":7530},"Miyoshi, K., Tsukumo, H., Nagami, T., Siomi, H. & Siomi, M. C. Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev. 19, 2837–2848 (2005).",{"doi":7531},"10.1101\u002Fgad.1370605",{"id":28,"text":7533,"url":28,"identifiers":7534},"Gredell, J. A., Dittmer, M. J., Wu, M., Chan, C. & Walton, S. P. Recognition of siRNA asymmetry by TAR RNA binding protein. Biochemistry 49, 3148–3155 (2010).",{"doi":7535},"10.1021\u002Fbi902189s",{"id":28,"text":7537,"url":28,"identifiers":7538},"Noland, C. L., Ma, E. & Doudna, J. A. siRNA repositioning for guide strand selection by human Dicer complexes. Mol. Cell 43, 110–121 (2011).",{"doi":7539},"10.1016\u002Fj.molcel.2011.05.028",{"id":28,"text":7541,"url":28,"identifiers":7542},"Liu, X., Jin, D. Y., McManus, M. T. & Mourelatos, Z. Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol. Cell 46, 507–517 (2012).",{"doi":7543},"10.1016\u002Fj.molcel.2012.03.010",{"id":28,"text":7545,"url":28,"identifiers":7546},"Betancur, J. G. & Tomari, Y. Dicer is dispensable for asymmetric RISC loading in mammals. RNA 18, 24–30 (2012).",{"doi":7547},"10.1261\u002Frna.029785.111",{"id":28,"text":7549,"url":28,"identifiers":7550},"Ye, X. et al. Structure of C3PO and mechanism of human RISC activation. Nature Struct. Mol. Biol. 18, 650–657 (2011).",{"doi":7551},"10.1038\u002Fnsmb.2032",{"id":28,"text":7553,"url":28,"identifiers":7554},"Diederichs, S. & Haber, D. A. Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell 131, 1097–1108 (2007).",{"doi":7555},"10.1016\u002Fj.cell.2007.10.032",{"id":28,"text":7557,"url":28,"identifiers":7558},"Leuschner, P. J., Ameres, S. L., Kueng, S. & Martinez, J. Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep. 7, 314–320 (2006).",{"doi":7559},"10.1038\u002Fsj.embor.7400637",{"id":28,"text":7561,"url":28,"identifiers":7562},"Matranga, C., Tomari, Y., Shin, C., Bartel, D. P. & Zamore, P. D. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607–620 (2005).",{"doi":7563},"10.1016\u002Fj.cell.2005.08.044",{"id":28,"text":7565,"url":28,"identifiers":7566},"Rand, T. A., Petersen, S., Du, F. & Wang, X. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 123, 621–629 (2005).",{"doi":7567},"10.1016\u002Fj.cell.2005.10.020",{"id":28,"text":7569,"url":28,"identifiers":7570},"Nykanen, A., Haley, B. & Zamore, P. D. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107, 309–321 (2001).",{"doi":7571},"10.1016\u002FS0092-8674(01)00547-5",{"id":28,"text":7573,"url":28,"identifiers":7574},"Iwasaki, S. et al. Hsc70\u002FHsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes. Mol. Cell 39, 292–299 (2010).",{"doi":7575},"10.1016\u002Fj.molcel.2010.05.015",{"id":28,"text":7577,"url":28,"identifiers":7578},"Miyoshi, K., Miyoshi, T., Hartig, J. V., Siomi, H. & Siomi, M. C. Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila. RNA 16, 506–515 (2010).",{"doi":7579},"10.1261\u002Frna.1952110",{"id":28,"text":7581,"url":28,"identifiers":7582},"Han, B. W., Hung, J. H., Weng, Z., Zamore, P. D. & Ameres, S. L. The 3′-to-5′ exoribonuclease Nibbler shapes the 3′ ends of microRNAs bound to Drosophila Argonaute1. Curr. Biol. 21, 1878–1887 (2011).",{"doi":7583},"10.1016\u002Fj.cub.2011.09.034",{"id":28,"text":7585,"url":28,"identifiers":7586},"Liu, N. et al. The exoribonuclease Nibbler controls 3′ end processing of microRNAs in Drosophila. Curr. Biol. 21, 1888–1893 (2011).",{"doi":7587},"10.1016\u002Fj.cub.2011.10.006",{"id":28,"text":7589,"url":28,"identifiers":7590},"Khvorova, A., Reynolds, A. & Jayasena, S. D. Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209–216 (2003).",{"doi":7591},"10.1016\u002FS0092-8674(03)00801-8",{"id":28,"text":7593,"url":28,"identifiers":7594},"Schwarz, D. S. et al. Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199–208 (2003).",{"doi":7595},"10.1016\u002FS0092-8674(03)00759-1",{"id":28,"text":7597,"url":28,"identifiers":7598},"Hu, H. Y. et al. Sequence features associated with microRNA strand selection in humans and flies. BMC Genomics 10, 413 (2009).",{"doi":7599},"10.1186\u002F1471-2164-10-413",{"id":28,"text":7601,"url":28,"identifiers":7602},"Lau, N. C., Lim, L. P., Weinstein, E. G. & Bartel, D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858–862 (2001).",{"doi":7603},"10.1126\u002Fscience.1065062",{"id":28,"text":7605,"url":28,"identifiers":7606},"Wu, H., Ye, C., Ramirez, D. & Manjunath, N. Alternative processing of primary microRNA transcripts by Drosha generates 5′ end variation of mature microRNA. PLoS ONE 4, e7566 (2009).",{"doi":7607},"10.1371\u002Fjournal.pone.0007566",{"id":28,"text":7609,"url":28,"identifiers":7610},"Qi, H. H. et al. Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature 455, 421–424 (2008).",{"doi":7611},"10.1038\u002Fnature07186",{"id":28,"text":7613,"url":28,"identifiers":7614},"Wu, C. et al. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol. Cell. Biol. 31, 4760–4774 (2011).",{"doi":7615},"10.1128\u002FMCB.05776-11",{"id":28,"text":7617,"url":28,"identifiers":7618},"Zeng, Y., Sankala, H., Zhang, X. & Graves, P. R. Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. Biochem. J. 413, 429–436 (2008).",{"doi":7619},"10.1042\u002FBJ20080599",{"id":28,"text":7621,"url":28,"identifiers":7622},"Horman, S. R. et al. Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of microRNA targets. Mol. Cell 50, 356–367 (2013).",{"doi":7623},"10.1016\u002Fj.molcel.2013.03.015",{"id":28,"text":7625,"url":28,"identifiers":7626},"Shen, J. et al. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 497, 383–387 (2013).",{"doi":7627},"10.1038\u002Fnature12080",{"id":28,"text":7629,"url":28,"identifiers":7630},"Rudel, S. et al. Phosphorylation of human Argonaute proteins affects small RNA binding. Nucleic Acids Res. 39, 2330–2343 (2011).",{"doi":7631},"10.1093\u002Fnar\u002Fgkq1032",{"id":28,"text":7633,"url":28,"identifiers":7634},"Mazumder, A., Bose, M., Chakraborty, A., Chakrabarti, S. & Bhattacharyya, S. N. A transient reversal of miRNA-mediated repression controls macrophage activation. EMBO Rep. 14, 1008–1016 (2013).",{"doi":7635},"10.1038\u002Fembor.2013.149",{"id":28,"text":7637,"url":28,"identifiers":7638},"Leung, A. K. et al. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol. Cell 42, 489–499 (2011).",{"doi":7639},"10.1016\u002Fj.molcel.2011.04.015",{"id":28,"text":7641,"url":28,"identifiers":7642},"Seo, G. J. et al. Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells. Cell Host Microbe 14, 435–445 (2013).",{"doi":7643},"10.1016\u002Fj.chom.2013.09.002",{"id":28,"text":7645,"url":28,"identifiers":7646},"Rybak, A. et al. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nature Cell Biol. 11, 1411–1420 (2009).",{"doi":7647},"10.1038\u002Fncb1987",{"id":28,"text":7649,"url":28,"identifiers":7650},"Johnston, M., Geoffroy, M. C., Sobala, A., Hay, R. & Hutvagner, G. HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells. Mol. Biol. Cell 21, 1462–1469 (2010).",{"doi":7651},"10.1091\u002Fmbc.e09-10-0885",{"id":28,"text":7653,"url":28,"identifiers":7654},"Smibert, P., Yang, J. S., Azzam, G., Liu, J. L. & Lai, E. C. Homeostatic control of Argonaute stability by microRNA availability. Nature Struct. Mol. Biol. 20, 789–795 (2013).",{"doi":7655},"10.1038\u002Fnsmb.2606",{"id":28,"text":7657,"url":28,"identifiers":7658},"Bronevetsky, Y. et al. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J. Exp. Med. 210, 417–432 (2013).",{"doi":7659},"10.1084\u002Fjem.20111717",{"id":28,"text":7661,"url":28,"identifiers":7662},"Loedige, I., Gaidatzis, D., Sack, R., Meister, G. & Filipowicz, W. The mammalian TRIM-NHL protein TRIM71\u002FLIN-41 is a repressor of mRNA function. Nucleic Acids Res. 41, 518–532 (2013).",{"doi":7663},"10.1093\u002Fnar\u002Fgks1032",{"id":28,"text":7665,"url":28,"identifiers":7666},"Chang, H. M. et al. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nature Commun. 3, 923 (2012).",{"doi":7667},"10.1038\u002Fncomms1909",{"id":28,"text":7669,"url":28,"identifiers":7670},"Chen, J., Lai, F. & Niswander, L. The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 26, 803–815 (2012).",{"doi":7671},"10.1101\u002Fgad.187641.112",{"id":28,"text":7673,"url":28,"identifiers":7674},"Martinez, N. J. & Gregory, R. I. Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA 19, 605–612 (2013).",{"doi":7675},"10.1261\u002Frna.036434.112",{"id":28,"text":7677,"url":28,"identifiers":7678},"Ryan, B. M., Robles, A. I. & Harris, C. C. Genetic variation in microRNA networks: the implications for cancer research. Nature Rev. Cancer 10, 389–402 (2010).",{"doi":7679},"10.1038\u002Fnrc2867",{"id":28,"text":7681,"url":28,"identifiers":7682},"Calin, G. A. et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N. Engl. J. Med. 353, 1793–1801 (2005).",{"doi":7683},"10.1056\u002FNEJMoa050995",{"id":28,"text":7685,"url":28,"identifiers":7686},"Tian, T. et al. A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese. Cancer Epidemiol. Biomarkers Prev. 18, 1183–1187 (2009).",{"doi":7687},"10.1158\u002F1055-9965.EPI-08-0814",{"id":28,"text":7689,"url":28,"identifiers":7690},"Jazdzewski, K. et al. Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. Proc. Natl Acad. Sci. USA 106, 1502–1505 (2009).",{"doi":7691},"10.1073\u002Fpnas.0812591106",{"id":28,"text":7693,"url":28,"identifiers":7694},"Jazdzewski, K. et al. Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc. Natl Acad. Sci. USA 105, 7269–7274 (2008).",{"doi":7695},"10.1073\u002Fpnas.0802682105",{"id":28,"text":7697,"url":28,"identifiers":7698},"Ameres, S. L. & Zamore, P. D. Diversifying microRNA sequence and function. Nature Rev. Mol. Cell Biol. 14, 475–488 (2013).",{"doi":7699},"10.1038\u002Fnrm3611",{"id":28,"text":7701,"url":28,"identifiers":7702},"Pasquinelli, A. E. et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408, 86–89 (2000).",{"doi":7703},"10.1038\u002F35040556",{"id":28,"text":7705,"url":28,"identifiers":7706},"Suh, M. R. et al. Human embryonic stem cells express a unique set of microRNAs. Dev. Biol. 270, 488–498 (2004).",{"doi":7707},"10.1016\u002Fj.ydbio.2004.02.019",{"id":28,"text":7709,"url":28,"identifiers":7710},"Thomson, J. M. et al. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 20, 2202–2207 (2006).",{"doi":7711},"10.1101\u002Fgad.1444406",{"id":28,"text":7713,"url":28,"identifiers":7714},"Wulczyn, F. G. et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J. 21, 415–426 (2007).",{"doi":7715},"10.1096\u002Ffj.06-6130com",{"id":28,"text":7717,"url":28,"identifiers":7718},"Heo, I. et al. Lin28 mediates the terminal uridylation of let-7 precursor microRNA. Mol. Cell 32, 276–284 (2008).",{"doi":7719},"10.1016\u002Fj.molcel.2008.09.014",{"id":28,"text":7721,"url":28,"identifiers":7722},"Newman, M. A., Thomson, J. M. & Hammond, S. M. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14, 1539–1549 (2008).",{"doi":7723},"10.1261\u002Frna.1155108",{"id":28,"text":7725,"url":28,"identifiers":7726},"Rybak, A. et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nature Cell Biol. 10, 987–993 (2008).",{"doi":7727},"10.1038\u002Fncb1759",{"id":28,"text":7729,"url":28,"identifiers":7730},"Viswanathan, S. R., Daley, G. Q. & Gregory, R. I. Selective blockade of microRNA processing by Lin28. Science 320, 97–100 (2008).",{"doi":7731},"10.1126\u002Fscience.1154040",{"id":28,"text":7733,"url":28,"identifiers":7734},"Loughlin, F. E. et al. Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28. Nature Struct. Mol. Biol. 19, 84–89 (2012).",{"doi":7735},"10.1038\u002Fnsmb.2202",{"id":28,"text":7737,"url":28,"identifiers":7738},"Nam, Y., Chen, C., Gregory, R. I., Chou, J. J. & Sliz, P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell 147, 1080–1091 (2011).",{"doi":7739},"10.1016\u002Fj.cell.2011.10.020",{"id":28,"text":7741,"url":28,"identifiers":7742},"Hagan, J. P., Piskounova, E. & Gregory, R. I. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nature Struct. Mol. Biol. 16, 1021–1025 (2009).",{"doi":7743},"10.1038\u002Fnsmb.1676",{"id":28,"text":7745,"url":28,"identifiers":7746},"Heo, I. et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138, 696–708 (2009).",{"doi":7747},"10.1016\u002Fj.cell.2009.08.002",{"id":28,"text":7749,"url":28,"identifiers":7750},"Chang, H. M., Triboulet, R., Thornton, J. E. & Gregory, R. I. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature 497, 244–248 (2013).",{"doi":7751},"10.1038\u002Fnature12119",{"id":28,"text":7753,"url":28,"identifiers":7754},"Ustianenko, D. et al. Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs. RNA 19, 1632–1638 (2013).",{"doi":7755},"10.1261\u002Frna.040055.113",{"id":28,"text":7757,"url":28,"identifiers":7758},"Heo, I. et al. Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs. Cell 151, 521–532 (2012).",{"doi":7759},"10.1016\u002Fj.cell.2012.09.022",{"id":28,"text":7761,"url":28,"identifiers":7762},"Katoh, T. et al. Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes Dev. 23, 433–438 (2009).",{"doi":7763},"10.1101\u002Fgad.1761509",{"id":28,"text":7765,"url":28,"identifiers":7766},"Backes, S. et al. Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism. Cell Host Microbe 12, 200–210 (2012).",{"doi":7767},"10.1016\u002Fj.chom.2012.05.019",{"id":28,"text":7769,"url":28,"identifiers":7770},"Yang, W. et al. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nature Struct. Mol. Biol. 13, 13–21 (2006).",{"doi":7771},"10.1038\u002Fnsmb1041",{"id":28,"text":7773,"url":28,"identifiers":7774},"Kawahara, Y., Zinshteyn, B., Chendrimada, T. P., Shiekhattar, R. & Nishikura, K. RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer–TRBP complex. EMBO Rep. 8, 763–769 (2007).",{"doi":7775},"10.1038\u002Fsj.embor.7401011",{"id":28,"text":7777,"url":28,"identifiers":7778},"Xhemalce, B., Robson, S. C. & Kouzarides, T. Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell 151, 278–288 (2012).",{"doi":7779},"10.1016\u002Fj.cell.2012.08.041",{"id":28,"text":7781,"url":28,"identifiers":7782},"Ruegger, S. & Grosshans, H. MicroRNA turnover: when, how, and why. Trends Biochem. Sci. 37, 436–446 (2012).",{"doi":7783},"10.1016\u002Fj.tibs.2012.07.002",{"id":28,"text":7785,"url":28,"identifiers":7786},"Suzuki, H. I. et al. MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Mol. Cell 44, 424–436 (2011).",{"doi":7787},"10.1016\u002Fj.molcel.2011.09.012",{"id":28,"text":7789,"url":28,"identifiers":7790},"Upton, J. P. et al. IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic caspase-2. Science 338, 818–822 (2012).",{"doi":7791},"10.1126\u002Fscience.1226191",{"id":28,"text":7793,"url":28,"identifiers":7794},"Ramachandran, V. & Chen, X. Degradation of microRNAs by a family of exoribonucleases in Arabidopsis. Science 321, 1490–1492 (2008).",{"doi":7795},"10.1126\u002Fscience.1163728",{"id":28,"text":7797,"url":28,"identifiers":7798},"Chatterjee, S., Fasler, M., Bussing, I. & Grosshans, H. Target-mediated protection of endogenous microRNAs in C. elegans. Dev. Cell 20, 388–396 (2011).",{"doi":7799},"10.1016\u002Fj.devcel.2011.02.008",{"id":28,"text":7801,"url":28,"identifiers":7802},"Chatterjee, S. & Grosshans, H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461, 546–549 (2009).",{"doi":7803},"10.1038\u002Fnature08349",{"id":28,"text":7805,"url":28,"identifiers":7806},"Krol, J. et al. Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell 141, 618–631 (2010).",{"doi":7807},"10.1016\u002Fj.cell.2010.03.039",{"id":28,"text":7809,"url":28,"identifiers":7810},"Das, S. K. et al. Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells. Proc. Natl Acad. Sci. USA 107, 11948–11953 (2010).",{"doi":7811},"10.1073\u002Fpnas.0914143107",{"id":28,"text":7813,"url":28,"identifiers":7814},"Thomas, M. F. et al. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood 120, 130–142 (2012).",{"doi":7815},"10.1182\u002Fblood-2011-11-394072",{"id":28,"text":7817,"url":28,"identifiers":7818},"Libri, V. et al. Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target. Proc. Natl Acad. Sci. USA 109, 279–284 (2012).",{"doi":7819},"10.1073\u002Fpnas.1114204109",{"id":28,"text":7821,"url":28,"identifiers":7822},"Ameres, S. L. et al. Target RNA-directed trimming and tailing of small silencing RNAs. Science 328, 1534–1539 (2010).",{"doi":7823},"10.1126\u002Fscience.1187058",{"id":28,"text":7825,"url":28,"identifiers":7826},"Baccarini, A. et al. Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells. Curr. Biol. 21, 369–376 (2011).",{"doi":7827},"10.1016\u002Fj.cub.2011.01.067",{"id":28,"text":7829,"url":28,"identifiers":7830},"Xie, J. et al. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nature Methods 9, 403–409 (2012).",{"doi":7831},"10.1038\u002Fnmeth.1903",{"id":28,"text":7833,"url":28,"identifiers":7834},"Cazalla, D., Yario, T. & Steitz, J. A. Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA. Science 328, 1563–1566 (2010).",{"doi":7835},"10.1126\u002Fscience.1187197",{"id":28,"text":7837,"url":28,"identifiers":7838},"Lee, S. et al. Selective degradation of host MicroRNAs by an intergenic HCMV noncoding RNA accelerates virus production. Cell Host Microbe 13, 678–690 (2013).",{"doi":7839},"10.1016\u002Fj.chom.2013.05.007",{"id":28,"text":7841,"url":28,"identifiers":7842},"Xie, M. & Steitz, J. A. Versatile microRNA biogenesis in animals and their viruses. RNA Biol. http:\u002F\u002Fdx.doi.org\u002F10.4161\u002Frna.28985 (2014).",{"doi":7843},"10.4161\u002Frna.28985",{"id":28,"text":7845,"url":28,"identifiers":7846},"Berezikov, E., Chung, W. J., Willis, J., Cuppen, E. & Lai, E. C. Mammalian mirtron genes. Mol. Cell 28, 328–336 (2007).",{"doi":7847},"10.1016\u002Fj.molcel.2007.09.028",{"id":28,"text":7849,"url":28,"identifiers":7850},"Okamura, K., Hagen, J. W., Duan, H., Tyler, D. M. & Lai, E. C. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 130, 89–100 (2007).",{"doi":7851},"10.1016\u002Fj.cell.2007.06.028",{"id":28,"text":7853,"url":28,"identifiers":7854},"Ruby, J. G., Jan, C. H. & Bartel, D. P. Intronic microRNA precursors that bypass Drosha processing. Nature 448, 83–86 (2007).",{"doi":7855},"10.1038\u002Fnature05983",{"id":28,"text":7857,"url":28,"identifiers":7858},"Flynt, A. S., Greimann, J. C., Chung, W. J., Lima, C. D. & Lai, E. C. MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Mol. Cell 38, 900–907 (2010).",{"doi":7859},"10.1016\u002Fj.molcel.2010.06.014",{"id":28,"text":7861,"url":28,"identifiers":7862},"Ender, C. et al. A human snoRNA with microRNA-like functions. Mol. Cell 32, 519–528 (2008).",{"doi":7863},"10.1016\u002Fj.molcel.2008.10.017",{"id":28,"text":7865,"url":28,"identifiers":7866},"Cazalla, D., Xie, M. & Steitz, J. A. A primate herpesvirus uses the integrator complex to generate viral microRNAs. Mol. Cell 43, 982–992 (2011).",{"doi":7867},"10.1016\u002Fj.molcel.2011.07.025",{"id":28,"text":7869,"url":28,"identifiers":7870},"Bogerd, H. P. et al. A mammalian herpesvirus uses noncanonical expression and processing mechanisms to generate viral microRNAs. Mol. Cell 37, 135–142 (2010).",{"doi":7871},"10.1016\u002Fj.molcel.2009.12.016",{"id":28,"text":7873,"url":28,"identifiers":7874},"Cifuentes, D. et al. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science 328, 1694–1698 (2010).",{"doi":7875},"10.1126\u002Fscience.1190809",{"id":28,"text":7877,"url":28,"identifiers":7878},"Yang, J. S. et al. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc. Natl Acad. Sci. USA 107, 15163–15168 (2010).",{"doi":7879},"10.1073\u002Fpnas.1006432107",{"id":28,"text":7881,"url":28,"identifiers":7882},"Yoda, M. et al. Poly(A)-specific ribonuclease mediates 3′-end trimming of Argonaute2-cleaved precursor microRNAs. Cell Rep. 5, 715–726 (2013).",{"doi":7883},"10.1016\u002Fj.celrep.2013.09.029",{"id":28,"text":7885,"url":28,"identifiers":7886},"Shenoy, A. & Blelloch, R. Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8. PLoS ONE 4, e6971 (2009).",{"doi":7887},"10.1371\u002Fjournal.pone.0006971",{"id":28,"text":7889,"url":28,"identifiers":7890},"Triboulet, R., Chang, H. M., Lapierre, R. J. & Gregory, R. I. Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA 15, 1005–1011 (2009).",{"doi":7891},"10.1261\u002Frna.1591709",{"id":28,"text":7893,"url":28,"identifiers":7894},"Karginov, F. V. et al. Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol. Cell 38, 781–788 (2010).",{"doi":7895},"10.1016\u002Fj.molcel.2010.06.001",{"id":28,"text":7897,"url":28,"identifiers":7898},"Lin, Y. T. & Sullivan, C. S. Expanding the role of Drosha to the regulation of viral gene expression. Proc. Natl Acad. Sci. USA 108, 11229–11234 (2011).",{"doi":7899},"10.1073\u002Fpnas.1105799108",{"id":28,"text":7901,"url":28,"identifiers":7902},"Heras, S. R. et al. The Microprocessor controls the activity of mammalian retrotransposons. Nature Struct. Mol. Biol. 20, 1173–1181 (2013).",{"doi":7903},"10.1038\u002Fnsmb.2658",{"id":28,"text":7905,"url":28,"identifiers":7906},"Macias, S. et al. DGCR8 HITS-CLIP reveals novel functions for the Microprocessor. Nature Struct. Mol. Biol. 19, 760–766 (2012).",{"doi":7907},"10.1038\u002Fnsmb.2344",{"id":28,"text":7909,"url":28,"identifiers":7910},"Luhur, A., Chawla, G., Wu, Y. C., Li, J. & Sokol, N. S. Drosha-independent DGCR8\u002FPasha pathway regulates neuronal morphogenesis. Proc. Natl Acad. Sci. USA 111, 1421–1426 (2014).",{"doi":7911},"10.1073\u002Fpnas.1318445111",{"id":28,"text":7913,"url":28,"identifiers":7914},"Kaneko, H. et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature 471, 325–330 (2011).",{"doi":7915},"10.1038\u002Fnature09830",{"id":28,"text":7917,"url":28,"identifiers":7918},"Hu, Q. et al. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Nature Struct. Mol. Biol. 19, 1168–1175 (2012).",{"doi":7919},"10.1038\u002Fnsmb.2400",{"id":28,"text":7921,"url":28,"identifiers":7922},"Meister, G. Argonaute proteins: functional insights and emerging roles. Nature Rev. Genet. 14, 447–459 (2013).",{"doi":7923},"10.1038\u002Fnrg3462",{"id":28,"text":7925,"url":28,"identifiers":7926},"Karamyshev, A. L. et al. Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway. Cell 156, 146–157 (2014).",{"doi":7927},"10.1016\u002Fj.cell.2013.12.017",{"id":28,"text":7929,"url":28,"identifiers":7930},"Ipsaro, J. J., Haase, A. D., Knott, S. R., Joshua-Tor, L. & Hannon, G. J. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 491, 279–283 (2012).",{"doi":7931},"10.1038\u002Fnature11502",{"id":28,"text":7933,"url":28,"identifiers":7934},"Nishimasu, H. et al. Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature 491, 284–287 (2012).",{"doi":7935},"10.1038\u002Fnature11509",{"id":28,"text":7937,"url":28,"identifiers":7938},"Siomi, M. C., Sato, K., Pezic, D. & Aravin, A. A. PIWI-interacting small RNAs: the vanguard of genome defence. Nature Rev. Mol. Cell Biol. 12, 246–258 (2011).",{"doi":7939},"10.1038\u002Fnrm3089",{"id":28,"text":7941,"url":28,"identifiers":7942},"Kataoka, N., Fujita, M. & Ohno, M. Functional association of the Microprocessor complex with the spliceosome. Mol. Cell Biol. 29, 3243–3254 (2009).",{"doi":7943},"10.1128\u002FMCB.00360-09",{"id":7945,"createTime":7946,"updateTime":7946,"relativeEntities":7947,"slug":7948,"properties":7949,"entityType":971,"verifyStatus":884,"verifyTime":7960,"verifyNote":7961,"languages":7962,"translateLanguages":28,"viewCount":32,"primaryUrl":7963,"fullTextUrl":28,"authors":7964,"publicationType":1063,"publisherRelationship":7995,"citationCount":8048,"citationInfo":8049,"publishDate":8060,"publishYear":4228,"citationAnalyzeStatus":884,"lastCitationAnalyze":28,"indexDatabases":8061,"openAccess":28,"references":8062,"isForceReanalyzing":1713},"bbc862ca-527b-4778-9972-dd943982d859","2024-09-01T11:53:27.467+00:00",[],"Soluble-protein-oligomers-in-neurodegeneration-lessons-from-the-Alzheimer-s-amyloid-%CE%B2-peptide",{"openalex":7950,"mag":7952,"title":7954,"pm":7956,"doi":7958},{"VOID":7951},"W1980825524",{"VOID":7953},"1980825524",{"EN":7955},"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide",{"VOID":7957},"17245412",{"VOID":7959},"10.1038\u002Fnrm2101","2024-09-01T11:53:27.466+00:00","Author affiliation is blank",[31],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnrm2101",[7965,7984],{"id":7966,"sortIndex":32,"researcher":28,"roles":7967,"affiliations":7968,"properties":7977,"displayName":7981,"givenName":28,"familyName":28},"a3fb8606-85bf-4816-8b05-f15c393c397b",[],[7969],{"id":7970,"sortIndex":32,"affiliation":7971,"properties":28},"fd66755e-73d5-4755-ab18-a1e0100b857c",{"id":7970,"createTime":28,"updateTime":28,"relativeEntities":7972,"slug":28,"properties":7973,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":7976,"statistic":28},[],{"title":7974},{"EN":7975},"Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig Maximilians University, 80336 Munich, Germany. chaass@med.uni-muenchen.de",[],{"orcid":7978,"title":7980,"openalex":7982},{"VOID":7979},"https:\u002F\u002Forcid.org\u002F0000-0002-4869-1627",{"EN":7981},"Christian Haass",{"VOID":7983},"A5065084452",{"id":7985,"sortIndex":40,"researcher":28,"roles":7986,"affiliations":7987,"properties":7988,"displayName":7992,"givenName":28,"familyName":28},"1dd9aba9-0394-4de3-af65-f7d99b2b5187",[],[],{"orcid":7989,"title":7991,"openalex":7993},{"VOID":7990},"https:\u002F\u002Forcid.org\u002F0000-0001-8846-9767",{"EN":7992},"Dennis J. 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Genetics of Parkinson's disease. Curr. Opin. Neurol. 18, 363–369 (2005).",{"doi":8066},"10.1097\u002F01.wco.0000170951.08924.3d",{"id":28,"text":8068,"url":28,"identifiers":8069},"Polymeropoulos, M. H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045–2047 (1997).",{"doi":8070},"10.1126\u002Fscience.276.5321.2045",{"id":28,"text":8072,"url":28,"identifiers":8073},"Kahle, P. J., Haass, C., Kretzschmar, H. A. & Neumann, M. Structure\u002Ffunction of α-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases. J. Neurochem. 82, 449–457 (2002).",{"doi":8074},"10.1046\u002Fj.1471-4159.2002.01020.x",{"id":28,"text":8076,"url":28,"identifiers":8077},"Spillantini, M. G. et al. α-Synuclein in Lewy bodies. Nature 388, 839–840 (1997).",{"doi":8078},"10.1038\u002F42166",{"id":28,"text":8080,"url":28,"identifiers":8081},"Baba, M. et al. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152, 879–884 (1998).",{},{"id":28,"text":8083,"url":28,"identifiers":8084},"Rosen, D. R. Mutations in Cu\u002FZn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 364, 362 (1993).",{"doi":8085},"10.1038\u002F364362c0",{"id":28,"text":8087,"url":28,"identifiers":8088},"Deng, H. X. et al. Amyotrophic lateral sclerosis and structural defects in Cu, Zn superoxide dismutase. Science 261, 1047–1051 (1993).",{"doi":8089},"10.1126\u002Fscience.8351519",{"id":28,"text":8091,"url":28,"identifiers":8092},"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 72, 971–983 (1993).",{"doi":8093},"10.1016\u002F0092-8674(93)90585-E",{"id":28,"text":8095,"url":28,"identifiers":8096},"Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatrie Psychisch-Gerichtl. Med. 64, 146–148 (1907).",{},{"id":28,"text":8098,"url":28,"identifiers":8099},"Glenner, G. G. & Wong, C. W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885–890 (1984).",{"doi":8100},"10.1016\u002FS0006-291X(84)80190-4",{"id":28,"text":8102,"url":28,"identifiers":8103},"Masters, C. L. et al. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl Acad. Sci. USA 82, 4245–4249 (1985).",{"doi":8104},"10.1073\u002Fpnas.82.12.4245",{"id":28,"text":8106,"url":28,"identifiers":8107},"Grundke-Iqbal, I. et al. Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology. Proc. Natl Acad. Sci. USA 83, 4913–4917 (1986).",{"doi":8108},"10.1073\u002Fpnas.83.13.4913",{"id":28,"text":8110,"url":28,"identifiers":8111},"Kosik, K. S., Joachim, C. L. & Selkoe, D. J. Microtubule-associated protein τ (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc. Natl Acad. Sci. USA 83, 4044–4048 (1986).",{"doi":8112},"10.1073\u002Fpnas.83.11.4044",{"id":28,"text":8114,"url":28,"identifiers":8115},"Nukina, N. & Ihara, Y. One of the antigenic determinants of paired helical filaments is related to τ protein. J. Biochem. 99, 1541–1544 (1986).",{"doi":8116},"10.1093\u002Foxfordjournals.jbchem.a135625",{"id":28,"text":8118,"url":28,"identifiers":8119},"Glenner, G. G. & Wong, C. W. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 122, 1131–1135 (1984).",{"doi":8120},"10.1016\u002F0006-291X(84)91209-9",{"id":28,"text":8122,"url":28,"identifiers":8123},"Olson, M. I. & Shaw, C. M. Presenile dementia and Alzheimer's disease in mongolism. Brain 92, 147–156 (1969).",{"doi":8124},"10.1093\u002Fbrain\u002F92.1.147",{"id":28,"text":8126,"url":28,"identifiers":8127},"Kang, J. et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733–736 (1987).",{"doi":8128},"10.1038\u002F325733a0",{"id":28,"text":8130,"url":28,"identifiers":8131},"Levy, E. et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248, 1124–1126 (1990).",{"doi":8132},"10.1126\u002Fscience.2111584",{"id":28,"text":8134,"url":28,"identifiers":8135},"Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704–706 (1991).",{"doi":8136},"10.1038\u002F349704a0",{"id":28,"text":8138,"url":28,"identifiers":8139},"Chartier-Harlin, M. C. et al. Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene. Nature 353, 844–846 (1991).",{"doi":8140},"10.1038\u002F353844a0",{"id":28,"text":8142,"url":28,"identifiers":8143},"Mullan, M. et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genet. 1, 345–347 (1992).",{"doi":8144},"10.1038\u002Fng0892-345",{"id":28,"text":8146,"url":28,"identifiers":8147},"Selkoe, D. J. The molecular pathology of Alzheimer's disease. Neuron 6, 487–498 (1991).",{"doi":8148},"10.1016\u002F0896-6273(91)90052-2",{"id":28,"text":8150,"url":28,"identifiers":8151},"Hardy, J. A. & Higgins, G. A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184–185 (1992). References 22 and 23 set out the amyloid cascade hypothesis, for which strong experimental evidence is now accumulating.",{"doi":8152},"10.1126\u002Fscience.1566067",{"id":28,"text":8154,"url":28,"identifiers":8155},"Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353–356 (2002).",{"doi":8156},"10.1126\u002Fscience.1072994",{"id":28,"text":8158,"url":28,"identifiers":8159},"Haass, C. et al. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322–325 (1992).",{"doi":8160},"10.1038\u002F359322a0",{"id":28,"text":8162,"url":28,"identifiers":8163},"Seubert, P. et al. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359, 325–327 (1992).",{"doi":8164},"10.1038\u002F359325a0",{"id":28,"text":8166,"url":28,"identifiers":8167},"Shoji, M. et al. Production of the Alzheimer amyloid β-protein by normal proteolytic processing. Science 258, 126–129 (1992).",{"doi":8168},"10.1126\u002Fscience.1439760",{"id":28,"text":8170,"url":28,"identifiers":8171},"Busciglio, J., Gabuzda, D. H., Matsudaira, P. & Yankner, B. A. Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc. Natl Acad. Sci. USA 90, 2092–2096 (1993).",{"doi":8172},"10.1073\u002Fpnas.90.5.2092",{"id":28,"text":8174,"url":28,"identifiers":8175},"Haass, C. Take five-BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation. EMBO J. 23, 483–488 (2004). A review on APP processing by β- and γ-secretase.",{"doi":8176},"10.1038\u002Fsj.emboj.7600061",{"id":28,"text":8178,"url":28,"identifiers":8179},"Brown, M. S., Ye, J., Rawson, R. B. & Goldstein, J. L. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100, 391–398 (2000).",{"doi":8180},"10.1016\u002FS0092-8674(00)80675-3",{"id":28,"text":8182,"url":28,"identifiers":8183},"Weihofen, A. & Martoglio, B. Intramembrane-cleaving proteases: controlled liberation of functional proteins and peptides from membranes. Trends Cell Biol. 13, 71–78 (2003).",{"doi":8184},"10.1016\u002FS0962-8924(02)00041-7",{"id":28,"text":8186,"url":28,"identifiers":8187},"Mumm, J. S. & Kopan, R. Notch signaling: from the outside in. Dev. Biol. 228, 151–165 (2000).",{"doi":8188},"10.1006\u002Fdbio.2000.9960",{"id":28,"text":8190,"url":28,"identifiers":8191},"Wolfe, M. S. et al. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398, 513–517 (1999).",{"doi":8192},"10.1038\u002F19077",{"id":28,"text":8194,"url":28,"identifiers":8195},"Steiner, H. et al. Glycine 384 is required for presenilin-1 function and is conserved in polytopic bacterial aspartyl proteases. Nature Cell Biol. 2, 848–851 (2000).",{"doi":8196},"10.1038\u002F35041097",{"id":28,"text":8198,"url":28,"identifiers":8199},"Kimberly, W. T. et al. γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc. Natl Acad. Sci. USA 100, 6382–6387 (2003).",{"doi":8200},"10.1073\u002Fpnas.1037392100",{"id":28,"text":8202,"url":28,"identifiers":8203},"Takasugi, N. et al. The role of presenilin cofactors in the γ-secretase complex. Nature 422, 438–441 (2003).",{"doi":8204},"10.1038\u002Fnature01506",{"id":28,"text":8206,"url":28,"identifiers":8207},"Edbauer, D. et al. Reconstitution of γ-secretase activity. Nature Cell Biol. 5, 486–488 (2003).",{"doi":8208},"10.1038\u002Fncb960",{"id":28,"text":8210,"url":28,"identifiers":8211},"Sastre, M. et al. Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2, 835–841 (2001).",{"doi":8212},"10.1093\u002Fembo-reports\u002Fkve180",{"id":28,"text":8214,"url":28,"identifiers":8215},"Weidemann, A. et al. A novel ε-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 41, 2825–2835 (2002).",{"doi":8216},"10.1021\u002Fbi015794o",{"id":28,"text":8218,"url":28,"identifiers":8219},"Gu, Y. et al. Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling γ-secretase-like cleavage of Notch. J. Biol. Chem. 276, 35235–35238 (2001).",{"doi":8220},"10.1074\u002Fjbc.C100357200",{"id":28,"text":8222,"url":28,"identifiers":8223},"Qi-Takahara, Y. et al. Longer forms of amyloid β protein: implications for the mechanism of intramembrane cleavage by γ-secretase. J. Neurosci. 25, 436–445 (2005).",{"doi":8224},"10.1523\u002FJNEUROSCI.1575-04.2005",{"id":28,"text":8226,"url":28,"identifiers":8227},"Zhao, G. et al. γ-cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J. Biol. Chem. 280, 37689–37697 (2005).",{"doi":8228},"10.1074\u002Fjbc.M507993200",{"id":28,"text":8230,"url":28,"identifiers":8231},"Dickson, D. W. The pathogenesis of senile plaques. J. Neuropathol. Exp. Neurol. 56, 321–339 (1997).",{"doi":8232},"10.1097\u002F00005072-199704000-00001",{"id":28,"text":8234,"url":28,"identifiers":8235},"Naslund, J. et al. Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. JAMA 283, 1571–1577 (2000).",{"doi":8236},"10.1001\u002Fjama.283.12.1571",{"id":28,"text":8238,"url":28,"identifiers":8239},"Lue, L. F. et al. Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155, 853–862 (1999).",{"doi":8240},"10.1016\u002FS0002-9440(10)65184-X",{"id":28,"text":8242,"url":28,"identifiers":8243},"McLean, C. A. et al. Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann. Neurol. 46, 860–866 (1999).",{"doi":8244},"10.1002\u002F1531-8249(199912)46:6\u003C860::AID-ANA8>3.0.CO;2-M",{"id":28,"text":8246,"url":28,"identifiers":8247},"Wang, J., Dickson, D. W., Trojanowski, J. Q. & Lee, V. M. The levels of soluble versus insoluble brain Aβ distinguish Alzheimer's disease from normal and pathologic aging. Exp. Neurol. 158, 328–337 (1999).",{"doi":8248},"10.1006\u002Fexnr.1999.7085",{"id":28,"text":8250,"url":28,"identifiers":8251},"Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R. & Finkbeiner, S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431, 805–810 (2004). Evidence that small, diffusible aggregates of intracellular huntingtin can confer neurotoxicity, perhaps analogously to soluble Aβ oligomers.",{"doi":8252},"10.1038\u002Fnature02998",{"id":28,"text":8254,"url":28,"identifiers":8255},"Schaffar, G. et al. Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol. Cell 15, 95–105 (2004).",{"doi":8256},"10.1016\u002Fj.molcel.2004.06.029",{"id":28,"text":8258,"url":28,"identifiers":8259},"Cummings, C. J. et al. Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron 24, 879–892 (1999).",{"doi":8260},"10.1016\u002FS0896-6273(00)81035-1",{"id":28,"text":8262,"url":28,"identifiers":8263},"Tsai, J., Grutzendler, J., Duff, K. & Gan, W. B. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nature Neurosci. 7, 1181–1183 (2004).",{"doi":8264},"10.1038\u002Fnn1335",{"id":28,"text":8266,"url":28,"identifiers":8267},"Caughey, B. & Lansbury, P. T. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu. Rev. Neurosci. 26, 267–298 (2003).",{"doi":8268},"10.1146\u002Fannurev.neuro.26.010302.081142",{"id":28,"text":8270,"url":28,"identifiers":8271},"Teplow, D. B. Structural and kinetic features of amyloid β-protein fibrillogenesis. Amyloid 5, 121–142 (1998).",{"doi":8272},"10.3109\u002F13506129808995290",{"id":28,"text":8274,"url":28,"identifiers":8275},"Harper, J. D., Wong, S. S., Lieber, C. M. & Lansbury, P. T. Observation of metastable Aβ amyloid protofibrils by atomic force microscopy. Chem. Biol. 4, 119–125 (1997).",{"doi":8276},"10.1016\u002FS1074-5521(97)90255-6",{"id":28,"text":8278,"url":28,"identifiers":8279},"Hartley, D. M. et al. Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J. Neurosci. 19, 8876–8884 (1999).",{"doi":8280},"10.1523\u002FJNEUROSCI.19-20-08876.1999",{"id":28,"text":8282,"url":28,"identifiers":8283},"Walsh, D. M., Lomakin, A., Benedek, G. B., Condron, M. M. & Teplow, D. B. Amyloid β-protein fibrillogenesis. Detection of a protofibrillar intermediate. J. Biol. Chem. 272, 22364–22372 (1997).",{"doi":8284},"10.1074\u002Fjbc.272.35.22364",{"id":28,"text":8286,"url":28,"identifiers":8287},"Walsh, D. M. et al. Amyloid β-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J. Biol. Chem. 274, 25945–25952 (1999).",{"doi":8288},"10.1074\u002Fjbc.274.36.25945",{"id":28,"text":8290,"url":28,"identifiers":8291},"Bitan, G. et al. Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways. Proc. Natl Acad. Sci. USA 100, 330–335 (2003).",{"doi":8292},"10.1073\u002Fpnas.222681699",{"id":28,"text":8294,"url":28,"identifiers":8295},"Lashuel, H. A., Hartley, D., Petre, B. M., Walz, T. & Lansbury, P. T. Jr. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature 418, 291 (2002).",{"doi":8296},"10.1038\u002F418291a",{"id":28,"text":8298,"url":28,"identifiers":8299},"Lambert, M. P. et al. Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins. Proc. Natl Acad. Sci. USA 95, 6448–6453 (1998).",{"doi":8300},"10.1073\u002Fpnas.95.11.6448",{"id":28,"text":8302,"url":28,"identifiers":8303},"Gong, Y. et al. Alzheimer's disease-affected brain: presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl Acad. Sci. USA 100, 10417–10422 (2003).",{"doi":8304},"10.1073\u002Fpnas.1834302100",{"id":28,"text":8306,"url":28,"identifiers":8307},"Lesne, S. et al. A specific amyloid-β protein assembly in the brain impairs memory. Nature 440, 352–357 (2006). Identification of a brain-derived Aβ oligomeric assembly, which impairs memory.",{"doi":8308},"10.1038\u002Fnature04533",{"id":28,"text":8310,"url":28,"identifiers":8311},"Podlisny, M. B. et al. Aggregation of secreted amyloid β-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J. Biol. Chem. 270, 9564–9570 (1995).",{"doi":8312},"10.1074\u002Fjbc.270.16.9564",{"id":28,"text":8314,"url":28,"identifiers":8315},"Walsh, D. M., Tseng, B. P., Rydel, R. E., Podlisny, M. B. & Selkoe, D. J. The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain. Biochemistry 39, 10831–10839 (2000).",{"doi":8316},"10.1021\u002Fbi001048s",{"id":28,"text":8318,"url":28,"identifiers":8319},"Funato, H., Enya, M., Yoshimura, M., Morishima-Kawashima, M. & Ihara, Y. Presence of sodium dodecyl sulfate-stable amyloid β-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation. Am. J. Pathol. 155, 23–28 (1999).",{"doi":8320},"10.1016\u002FS0002-9440(10)65094-8",{"id":28,"text":8322,"url":28,"identifiers":8323},"Enya, M. et al. Appearance of sodium dodecyl sulfate-stable amyloid β-protein (Aβ) dimer in the cortex during aging. Am. J. Pathol. 154, 271–279 (1999).",{"doi":8324},"10.1016\u002FS0002-9440(10)65273-X",{"id":28,"text":8326,"url":28,"identifiers":8327},"Kawarabayashi, T. et al. Dimeric amyloid β protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated τ accumulation in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 24, 3801–3809 (2004).",{"doi":8328},"10.1523\u002FJNEUROSCI.5543-03.2004",{"id":28,"text":8330,"url":28,"identifiers":8331},"Roher, A. E. et al. Morphology and toxicity of Aβ-(1–42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. J. Biol. Chem. 271, 20631–20635 (1996).",{"doi":8332},"10.1074\u002Fjbc.271.34.20631",{"id":28,"text":8334,"url":28,"identifiers":8335},"Walsh, D. M. et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535–539 (2002). Defines a synaptotoxic function for small, soluble oligomers of secreted Aβ in vivo.",{"doi":8336},"10.1038\u002F416535a",{"id":28,"text":8338,"url":28,"identifiers":8339},"Kamenetz, F. et al. APP processing and synaptic function. Neuron 37, 925–937 (2003). Demonstrates the effects of Aβ on synaptic function upon the stimulation of neuronal activity.",{"doi":8340},"10.1016\u002FS0896-6273(03)00124-7",{"id":28,"text":8342,"url":28,"identifiers":8343},"Townsend, M., Shankar, G. M., Mehta, T., Walsh, D. M. & Selkoe, D. J. Effects of secreted oligomers of amyloid β-protein on hippocampal synaptic plasticity: a potent role for trimers. J. Physiol. 572, 477–492 (2006).",{"doi":8344},"10.1113\u002Fjphysiol.2005.103754",{"id":28,"text":8346,"url":28,"identifiers":8347},"Klyubin, I. et al. Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo. Nature Med. 11, 556–561 (2005). LTP inhibition by soluble oligomers of human Aβ is prevented by active and passive Aβ immunotherapy.",{"doi":8348},"10.1038\u002Fnm1234",{"id":28,"text":8350,"url":28,"identifiers":8351},"Cleary, J. P. et al. Natural oligomers of the amyloid-β protein specifically disrupt cognitive function. Nature Neurosci. 8, 79–84 (2005).",{"doi":8352},"10.1038\u002Fnn1372",{"id":28,"text":8354,"url":28,"identifiers":8355},"Cirrito, J. R. et al. Synaptic activity regulates interstitial fluid amyloid-β levels in vivo. Neuron 48, 913–922 (2005). An in vivo demonstration of the effects of synaptic activity on Aβ levels.",{"doi":8356},"10.1016\u002Fj.neuron.2005.10.028",{"id":28,"text":8358,"url":28,"identifiers":8359},"Snyder, E. M. et al. Regulation of NMDA receptor trafficking by amyloid-β. Nature Neurosci. 8, 1051–1058 (2005). A cellular mechanism that describes how Aβ lowers NMDA-evoked currents.",{"doi":8360},"10.1038\u002Fnn1503",{"id":28,"text":8362,"url":28,"identifiers":8363},"Gong, B. et al. Ubiquitin hydrolase Uch-L1 rescues β-amyloid-induced decreases in synaptic function and contextual memory. Cell 126, 775–788 (2006).",{"doi":8364},"10.1016\u002Fj.cell.2006.06.046",{"id":28,"text":8366,"url":28,"identifiers":8367},"Meyer-Luehmann, M. et al. Exogenous induction of cerebral β-amyloidogenesis is governed by agent and host. Science 313, 1781–1784 (2006).",{"doi":8368},"10.1126\u002Fscience.1131864",{"id":28,"text":8370,"url":28,"identifiers":8371},"Glabe, C. G. & Kayed, R. Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology 66, S74–S78 (2006).",{"doi":8372},"10.1212\u002F01.wnl.0000192103.24796.42",{"id":28,"text":8374,"url":28,"identifiers":8375},"Kayed, R. et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486–489 (2003). Describes common conformational epitopes on oligomers of completely distinct amyloidogenic proteins.",{"doi":8376},"10.1126\u002Fscience.1079469",{"id":28,"text":8378,"url":28,"identifiers":8379},"Lashuel, H. A. et al. α-Synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J. Mol. Biol. 322, 1089–1102 (2002).",{"doi":8380},"10.1016\u002FS0022-2836(02)00735-0",{"id":28,"text":8382,"url":28,"identifiers":8383},"Conway, K. A., Harper, J. D. & Lansbury, P. T. Jr. Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 39, 2552–2563 (2000).",{"doi":8384},"10.1021\u002Fbi991447r",{"id":28,"text":8386,"url":28,"identifiers":8387},"Conway, K. A., Harper, J. D. & Lansbury, P. T. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease. Nature Med. 4, 1318–1320 (1998).",{"doi":8388},"10.1038\u002F3311",{"id":28,"text":8390,"url":28,"identifiers":8391},"Conway, K. A. et al. Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl Acad. Sci. USA 97, 571–576 (2000).",{"doi":8392},"10.1073\u002Fpnas.97.2.571",{"id":28,"text":8394,"url":28,"identifiers":8395},"Marchut, A. J. & Hall, C. K. Spontaneous formation of annular structures observed in molecular dynamics simulations of polyglutamine peptides. Comput. Biol. Chem. 30, 215–218 (2006).",{"doi":8396},"10.1016\u002Fj.compbiolchem.2006.01.003",{"id":28,"text":8398,"url":28,"identifiers":8399},"Srinivasan, R., Marchant, R. E. & Zagorski, M. G. ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures. Amyloid 11, 10–13 (2004).",{"doi":8400},"10.1080\u002F13506120410001667872",{"id":28,"text":8402,"url":28,"identifiers":8403},"Wille, H., Drewes, G., Biernat, J., Mandelkow, E. M. & Mandelkow, E. Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein τ in vitro. J. Cell. Biol. 118, 573–584 (1992).",{"doi":8404},"10.1083\u002Fjcb.118.3.573",{"id":28,"text":8406,"url":28,"identifiers":8407},"Friedhoff, P., von Bergen, M., Mandelkow, E. M., Davies, P. & Mandelkow, E. A nucleated assembly mechanism of Alzheimer paired helical filaments. Proc. Natl Acad. Sci. USA 95, 15712–15717 (1998).",{"doi":8408},"10.1073\u002Fpnas.95.26.15712",{"id":28,"text":8410,"url":28,"identifiers":8411},"Neumann, M. et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130–133 (2006).",{"doi":8412},"10.1126\u002Fscience.1134108",{"id":28,"text":8414,"url":28,"identifiers":8415},"Willem, M. et al. Control of peripheral nerve myelination by the β-secretase BACE1. Science 314, 664–666 (2006).",{"doi":8416},"10.1126\u002Fscience.1132341",{"id":28,"text":8418,"url":28,"identifiers":8419},"Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173–177 (1999). Initial report of the beneficial effects of Aβ immunotherapy in a transgenic mouse model of AD.",{"doi":8420},"10.1038\u002F22124",{"id":28,"text":8422,"url":28,"identifiers":8423},"Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916–919 (2000).",{"doi":8424},"10.1038\u002F78682",{"id":28,"text":8426,"url":28,"identifiers":8427},"Orgogozo, J. M. et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology 61, 46–54 (2003).",{"doi":8428},"10.1212\u002F01.WNL.0000073623.84147.A8",{"id":28,"text":8430,"url":28,"identifiers":8431},"Hock, C. et al. Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547–554 (2003). First report of the beneficial effects of Aβ immunotherapy in a small cohort of vaccinated patients with AD.",{"doi":8432},"10.1016\u002FS0896-6273(03)00294-0",{"id":28,"text":8434,"url":28,"identifiers":8435},"Gilman, S. et al. Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64, 1553–1562 (2005).",{"doi":8436},"10.1212\u002F01.WNL.0000159740.16984.3C",{"id":28,"text":8438,"url":28,"identifiers":8439},"Nicoll, J. A. et al. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report. Nature Med. 9, 448–452 (2003). First report of the apparent removal of Aβ deposits in humans by a therapeutic agent.",{"doi":8440},"10.1038\u002Fnm840",{"id":28,"text":8442,"url":28,"identifiers":8443},"Patton, R. L. et al. Amyloid-β peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. Am. J. Pathol. 169, 1048–1063 (2006).",{"doi":8444},"10.2353\u002Fajpath.2006.060269",{"id":28,"text":8446,"url":28,"identifiers":8447},"Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H. & LaFerla, F. M. Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated τ aggregates via the proteasome. Neuron 43, 321–332 (2004). Further evidence of a linear connection between Aβ deposition and tau hyperphosphorylation in an animal model.",{"doi":8448},"10.1016\u002Fj.neuron.2004.07.003",{"id":28,"text":8450,"url":28,"identifiers":8451},"DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M. & Holtzman, D. M. Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295, 2264–2267 (2002).",{"doi":8452},"10.1126\u002Fscience.1067568",{"id":28,"text":8454,"url":28,"identifiers":8455},"Dodart, J. C. et al. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model. Nature Neurosci. 5, 452–457 (2002).",{"doi":8456},"10.1038\u002Fnn842",{"id":28,"text":8458,"url":28,"identifiers":8459},"Janus, C. et al. A β peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408, 979–982 (2000).",{"doi":8460},"10.1038\u002F35050110",{"id":28,"text":8462,"url":28,"identifiers":8463},"Gelinas, D. S., DaSilva, K., Fenili, D., St George-Hyslop, P. & McLaurin, J. Immunotherapy for Alzheimer's disease. Proc. Natl Acad. Sci. USA 101, 14657–14662 (2004).",{"doi":8464},"10.1073\u002Fpnas.0404866101",{"id":28,"text":8466,"url":28,"identifiers":8467},"Selkoe, D. J. & Schenk, D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 43, 545–584 (2003).",{"doi":8468},"10.1146\u002Fannurev.pharmtox.43.100901.140248",{"id":28,"text":8470,"url":28,"identifiers":8471},"McLaurin, J. et al. Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis. Nature Med. 8, 1263–1269 (2002). Important mechanistic insights about how Aβ immunotherapy can prevent oligomerization and cytotoxicity.",{"doi":8472},"10.1038\u002Fnm790",{"id":28,"text":8474,"url":28,"identifiers":8475},"Solomon, B., Koppel, R., Hanan, E. & Katzav, T. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer β-amyloid peptide. Proc. Natl Acad. Sci. USA 93, 452–455 (1996).",{"doi":8476},"10.1073\u002Fpnas.93.1.452",{"id":28,"text":8478,"url":28,"identifiers":8479},"Qiu, W. Q. et al. Insulin-degrading enzyme regulates extracellular levels of amyloid β- protein by degradation. J. Biol. Chem. 273, 32730–32738 (1998).",{"doi":8480},"10.1074\u002Fjbc.273.49.32730",{"id":28,"text":8482,"url":28,"identifiers":8483},"Tucker, H. M. et al. The plasmin system is induced by and degrades amyloid-β aggregates. J. Neurosci. 20, 3937–3946 (2000).",{"doi":8484},"10.1523\u002FJNEUROSCI.20-11-03937.2000",{"id":28,"text":8486,"url":28,"identifiers":8487},"Mueller-Steiner, S. et al. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 51, 703–714 (2006).",{"doi":8488},"10.1016\u002Fj.neuron.2006.07.027",{"id":28,"text":8490,"url":28,"identifiers":8491},"Iwata, N. et al. Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nature Med. 6, 143–150 (2000).",{"doi":8492},"10.1038\u002F72237",{"id":28,"text":8494,"url":28,"identifiers":8495},"Leissring, M. A. et al. Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40, 1087–1093 (2003).",{"doi":8496},"10.1016\u002FS0896-6273(03)00787-6",{"id":28,"text":8498,"url":28,"identifiers":8499},"Huang, S. M. et al. Neprilysin-sensitive synapse-associated Aβ oligomers impair neuronal plasticity and cognitive function. J. Biol. Chem. 281, 17941–17951 (2006).",{"doi":8500},"10.1074\u002Fjbc.M601372200",{"id":28,"text":8502,"url":28,"identifiers":8503},"McLaurin, J., Franklin, T., Zhang, X., Deng, J. & Fraser, P. E. Interactions of Alzheimer amyloid-β peptides with glycosaminoglycans effects on fibril nucleation and growth. Eur. J. Biochem. 266, 1101–1110 (1999).",{"doi":8504},"10.1046\u002Fj.1432-1327.1999.00957.x",{"id":28,"text":8506,"url":28,"identifiers":8507},"McLaurin, J., Golomb, R., Jurewicz, A., Antel, J. P. & Fraser, P. E. Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit aβ-induced toxicity. J. Biol. Chem. 275, 18495–18502 (2000).",{"doi":8508},"10.1074\u002Fjbc.M906994199",{"id":28,"text":8510,"url":28,"identifiers":8511},"McLaurin, J. et al. Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nature Med. 12, 801–808 (2006). New Aβ-aggregation inhibitors show beneficial effects on plaque burden and behaviour in mice.",{"doi":8512},"10.1038\u002Fnm1423",{"id":28,"text":8514,"url":28,"identifiers":8515},"Weggen, S. et al. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 414, 212–216 (2001). Discovery of certain NSAIDs as γ-secretase modulators: they lead to shorter, less amyloidogenic Aβ species.",{"doi":8516},"10.1038\u002F35102591",{"id":28,"text":8518,"url":28,"identifiers":8519},"Doerfler, P., Shearman, M. S. & Perlmutter, R. M. Presenilin-dependent γ-secretase activity modulates thymocyte development. Proc. Natl Acad. Sci. USA 98, 9312–9317 (2001).",{"doi":8520},"10.1073\u002Fpnas.161102498",{"id":28,"text":8522,"url":28,"identifiers":8523},"Geling, A., Steiner, H., Willem, M., Bally-Cuif, L. & Haass, C. A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep. 3, 688–694 (2002).",{"doi":8524},"10.1093\u002Fembo-reports\u002Fkvf124",{"id":28,"text":8526,"url":28,"identifiers":8527},"Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864–870 (1996).",{"doi":8528},"10.1038\u002Fnm0896-864",{"id":28,"text":8530,"url":28,"identifiers":8531},"Suzuki, N. et al. An increased percentage of long amyloid β-protein secreted by familial amyloid β-protein precursor (βAPP717) mutants. Science 264, 1336–1340 (1994).",{"doi":8532},"10.1126\u002Fscience.8191290",{"id":28,"text":8534,"url":28,"identifiers":8535},"Burdick, D. et al. Assembly and aggregation properties of synthetic Alzheimer's A4\u002Fβ amyloid peptide analogs. J. Biol. Chem. 267, 546–554 (1992).",{"doi":8536},"10.1016\u002FS0021-9258(18)48529-8",{"id":28,"text":8538,"url":28,"identifiers":8539},"Jarrett, J. T., Berger, E. P. & Lansbury, P. T. Jr. The carboxy terminus of the β-amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32, 4693–4697 (1993).",{"doi":8540},"10.1021\u002Fbi00069a001",{"id":28,"text":8542,"url":28,"identifiers":8543},"Chen, Y. R. & Glabe, C. G. Distinct early folding and aggregation properties of Alzheimer amyloid-β peptides Aβ40 and Aβ42: stable trimer or tetramer formation by Aβ42. J. Biol. Chem. 281, 24414–24422 (2006).",{"doi":8544},"10.1074\u002Fjbc.M602363200",{"id":28,"text":8546,"url":28,"identifiers":8547},"Nilsberth, C. et al. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation. Nature Neurosci. 4, 887–893 (2001). A genetic explanation for the development of rare forms of AD that is strongly supportive of the amyloid hypothesis.",{"doi":8548},"10.1038\u002Fnn0901-887",{"id":28,"text":8550,"url":28,"identifiers":8551},"Iwatsubo, T. et al. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 13, 45–53 (1994).",{"doi":8552},"10.1016\u002F0896-6273(94)90458-8",{"id":28,"text":8554,"url":28,"identifiers":8555},"Cai, X. D., Golde, T. E. & Younkin, S. G. Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science 259, 514–516 (1993).",{"doi":8556},"10.1126\u002Fscience.8424174",{"id":28,"text":8558,"url":28,"identifiers":8559},"Citron, M. et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360, 672–674 (1992).",{"doi":8560},"10.1038\u002F360672a0",{"id":28,"text":8562,"url":28,"identifiers":8563},"Rovelet-Lecrux, A. et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nature Genet. 38, 24–26 (2006).",{"doi":8564},"10.1038\u002Fng1718",{"id":28,"text":8566,"url":28,"identifiers":8567},"Singleton, A. B. et al. α-Synuclein locus triplication causes Parkinson's disease. Science 302, 841 (2003).",{"doi":8568},"10.1126\u002Fscience.1090278",{"id":28,"text":8570,"url":28,"identifiers":8571},"McGowan, E. et al. Aβ42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47, 191–199 (2005).",{"doi":8572},"10.1016\u002Fj.neuron.2005.06.030",{"id":28,"text":8574,"url":28,"identifiers":8575},"Bentahir, M. et al. Presenilin clinical mutations can affect γ-secretase activity by different mechanisms. J. Neurochem. 96, 732–742 (2006).",{"doi":8576},"10.1111\u002Fj.1471-4159.2005.03578.x",{"id":28,"text":8578,"url":28,"identifiers":8579},"Deng, Y. et al. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired γ-secretase activity and exacerbated amyloid pathology. J. Neurosci. 26, 3845–3854 (2006).",{"doi":8580},"10.1523\u002FJNEUROSCI.5384-05.2006"]