[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"\"}":3,"_public_publisher_byId_fb2b19f0-d2c3-49ba-8ecf-940b8beaa98b":656,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"totalCitation\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:fb2b19f0-d2c3-49ba-8ecf-940b8beaa98b,\"}":832},{"meta":4,"data":6},{"total":5},"117",[7,60,176,207,299,413,445,480,543,572],{"id":8,"createTime":9,"updateTime":10,"relativeEntities":11,"slug":12,"properties":13,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":29,"subjectFields":30,"manageAffiliations":31,"indexDatabases":32,"url":33,"thumbnailPath":34,"statistic":35,"gsStatistic":26,"type":26,"analyzePriority":26},"5a09599f-54d1-44c3-8f16-3847ac552024","2023-08-17T04:28:50.832+00:00","2025-10-13T23:58:52.517+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Truy%E1%BB%81n-nhi%E1%BB%85m-Vi%E1%BB%87t-Nam",{"country":14,"issn":16,"introduce":18,"title":21},{"VOID":15},"VN",{"VOID":17},"08667829",{"EN":19,"VI":20},"{\"ops\":[{\"insert\":\"Vietnam Journal of Infectious Diseases is a social - professional forum of the Vietnam Society for Infectious Diseases, whose responsibility is to introduce the researches, the scientific advances in Vietnam and from the world; to contribute to the improvement of knowledges for health care staffs about clinic, treatment, guideline, prevention, epidemiology for infectious diseases, HIV\u002FAIDS and community health care; to provide, exchange and publish scientific information to the public accurately and promptly.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Vietnam Journal of Infectious Diseases publishes in the whole country; serves the professional work for researchers, clinical staffs, administrators, undergraduate and postgraduate students who are working and studying in the infections, tropical diseases and HIV\u002FAIDS from central to local levels, also organizations and individuals in the world who are interested in infectious and tropical diseases and prevention for HIV\u002FAIDS.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Editor in Chief:\"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"insert\":\"Prof. Dr. Nguyen Van Kinh. - Chairman of Editorial Board\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"Prof. Dr. Nguyen Van Mui.\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Headquarter:\"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Address:\"},{\"insert\":\" Level 6, National Hospital for Tropical Diseases, No. 78 Giai Phong Street, Dong Da District, Hanoi city, Vietnam.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Tel:\"},{\"insert\":\" \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:02435765464\"},\"insert\":\"02435765464\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913552672\"},\"insert\":\"0913552672\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913228072\"},\"insert\":\"0913228072\"},{\"insert\":\".\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Email\"},{\"insert\":\": \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Findex\u002Fadmin\u002Fcontexts\u002Fmailto:tungphamvan52@gmail.com\"},\"insert\":\"tungphamvan52@gmail.com\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Fmailto:tapchitruyennhiem@gmail.com\"},\"insert\":\"tapchitruyennhiem@gmail.com\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Bank account:\"},{\"insert\":\" 0021000275119, Vietcombank Hanoi Branch. Transaction office No. 7, 402 Tran Khat Chan, Hai Ba Trung District, Hanoi city, Vietnam.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Tạp chí Truyền nhiễm Việt Nam là cơ quan ngôn luận của Hội Truyền nhiễm Việt Nam, chịu sự lãnh đạo, chỉ đạo trực tiếp của Thường vụ Ban Chấp hành Hội Truyền nhiễm Việt Nam; sự kiểm tra, giám sát về nghiệp vụ báo chí của các cơ quan chức năng quản lý báo chí thuộc Bộ Thông tin và Truyền thông và Ban Tuyên giáo Trung ương Đảng.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí có trách nhiệm giới thiệu các công trình nghiên cứu khoa học, những tiến bộ khoa học trên thế giới và trong nước, góp phần nâng cao kiến thức khoa học cho cán bộ y tế về lâm sàng, điều trị, hướng dẫn, dự phòng, dịch tễ học các bệnh truyền nhiễm, HIV\u002FAIDS và chăm sóc sức khỏe cộng đồng; cung cấp, trao đổi, phổ biến các thông tin khoa học tới công chúng chính xác và kịp thời.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Tạp chí xuất bản 03 tháng\u002F01 kỳ và được phát hành qua Bưu điện và tự phát hành trong phạm vi toàn quốc.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Lãnh đạo Tạp chí: \"},{\"attributes\":{\"header\":4},\"insert\":\"\\n\"},{\"insert\":\"Tổng Biên tập: ThS.BSCKII Nguyễn Trung Cấp\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"Phó Tổng Biên tập:\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"insert\":\"            TS.BSCKII Phạm Ngọc Thạch\"},{\"attributes\":{\"align\":\"justify\",\"blockquote\":true},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Trụ sở tòa soạn:\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Địa chỉ: Tầng 6, Bệnh viện Bệnh Nhiệt đới Trung ương, 78 đường Giải Phóng, phường Phương Mai, quận Đống Đa, thành phố Hà Nội.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Điện thoại:\"},{\"insert\":\" \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:02435765464\"},\"insert\":\"02435765464\"},{\"insert\":\" - \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Ftel:0913228072\"},\"insert\":\"0913228072\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Email\"},{\"insert\":\": \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Findex\u002Fadmin\u002Fcontexts\u002Fmailto:tungphamvan52@gmail.com\"},\"insert\":\"tungphamvan52@gmail.com\"},{\"insert\":\"; \"},{\"attributes\":{\"color\":\"#008d45\",\"background\":\"transparent\",\"link\":\"https:\u002F\u002Fbvnd.vojs.vn\u002Findex.php\u002Fvjid\u002Fmanagement\u002Fsettings\u002Fcontext\u002Fmailto:tapchitruyennhiem@gmail.com\"},\"insert\":\"tapchitruyennhiem@gmail.com\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Tài khoản:\"},{\"insert\":\" Số 0021000275119 Ngân hàng Ngoại thương Việt Nam, chi nhánh Hà Nội (Vietcombank Hà Nội). Phòng giao dịch số 7, 402 Trần Khát Chân, quận Hai Bà Trưng, Thành phố Hà Nội.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}",{"EN":22,"VI":23},"Vietnam Journal of Infectious Diseases","Tạp chí Truyền nhiễm Việt Nam","PUBLISHER","VERIFIED",null,"Admin update database","PENDING",51,[],[],[],"https:\u002F\u002Ftruyennhiemvietnam.vn\u002Findex.php\u002Fvjid","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F5a09599f-54d1-44c3-8f16-3847ac552024\u002Fadb0e52bf25e0de580fd4289519cb8bf.jpg",{"impactFactor":36,"impactFactorByYear":37,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":41,"totalPublicationByYear":42,"totalCitation":48,"totalCitationByYear":49,"totalCitationPerPublication":54,"totalCitationPerPublicationByYear":55,"hindexLast5Year":59,"hindex":59},0,{"2022":38,"2023":39,"2024":40},0.01,0.03,0.13,315,{"2020":43,"2021":44,"2022":45,"2023":46,"2024":47},63,58,57,65,72,43,{"2020":50,"2021":51,"2022":52,"2023":53},8,15,9,11,0.14,{"2020":40,"2021":56,"2022":57,"2023":58},0.26,0.16,0.17,3,{"id":61,"createTime":62,"updateTime":63,"relativeEntities":64,"slug":65,"properties":66,"entityType":24,"verifyStatus":25,"verifyTime":78,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":79,"subjectFields":80,"manageAffiliations":81,"indexDatabases":136,"url":137,"thumbnailPath":26,"statistic":138,"gsStatistic":155,"type":175,"analyzePriority":26},"25b6bd10-676c-40c0-8dc3-356d1679a284","2023-05-19T02:22:33.430+00:00","2026-06-18T23:33:57.141+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Y-D%C6%B0%E1%BB%A3c-h%E1%BB%8Dc-C%E1%BA%A7n-Th%C6%A1",{"country":67,"issn":68,"introduce":70,"title":73,"gsId":76},{"VOID":15},{"VOID":69},"23541210",{"EN":71,"VI":72},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"EN":74,"VI":75},"Cantho Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"VOID":77},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",32,[],[82],{"id":83,"createTime":84,"updateTime":85,"relativeEntities":86,"slug":87,"properties":88,"entityType":98,"verifyStatus":25,"verifyTime":99,"verifyNote":26,"syncStatus":28,"languages":100,"translateLanguages":26,"viewCount":103,"url":104,"parentIds":105,"statistic":106},"6413896b-eca9-442b-a73f-182a58a0ce40","2023-06-12T14:59:13.446+00:00","2026-06-19T02:29:32.871+00:00",[],"Tr%C6%B0%E1%BB%9Dng-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Y-D%C6%B0%E1%BB%A3c-C%E1%BA%A7n-Th%C6%A1",{"country":89,"title":90,"address":93,"abbreviation":96},{"VOID":15},{"EN":91,"VI":92},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"VI":94,"EN":95},"Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam","No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam",{"VOID":97},"ctump","AFFILIATION","2023-08-01T14:07:27.977+00:00",[101,102],"VI","EN",12,"http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":107,"i10Index":111,"i10IndexLast5Year":59,"totalPublication":112,"totalPublicationByYear":113,"totalCitation":122,"totalCitationByYear":123,"totalCitationPerPublication":128,"totalCitationPerPublicationByYear":129,"hindexLast5Year":135,"hindex":135},{"2022":108,"2023":109,"2024":110,"2025":38},0.1,0.05,0.07,4,1489,{"2013":114,"2014":115,"2015":115,"2016":111,"2017":115,"2018":59,"2019":114,"2020":116,"2021":117,"2022":118,"2023":119,"2024":120,"2025":121,"2026":111},2,1,10,84,281,680,260,156,313,{"2013":59,"2014":114,"2018":124,"2021":125,"2022":126,"2023":127},17,36,123,132,0.21,{"2013":130,"2014":114,"2018":131,"2021":132,"2022":133,"2023":134},1.5,5.67,0.43,0.44,0.19,6,[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":36,"impactFactorByYear":139,"i10Index":114,"i10IndexLast5Year":114,"totalPublication":140,"totalPublicationByYear":141,"totalCitation":147,"totalCitationByYear":148,"totalCitationPerPublication":151,"totalCitationPerPublicationByYear":152,"hindexLast5Year":135,"hindex":135},{"2022":38,"2023":36,"2024":39,"2025":38},1956,{"0":114,"2019":114,"2020":50,"2021":142,"2022":143,"2023":144,"2024":145,"2025":146},76,403,789,305,371,524,{"0":114,"2019":135,"2021":124,"2022":149,"2023":150,"2024":111,"2025":114},287,206,0.27,{"0":115,"2019":59,"2021":153,"2022":154,"2023":56,"2024":38,"2025":38},0.22,0.71,{"impactFactor":26,"impactFactorByYear":26,"i10Index":114,"i10IndexLast5Year":114,"totalPublication":156,"totalPublicationByYear":157,"totalCitation":163,"totalCitationByYear":164,"totalCitationPerPublication":169,"totalCitationPerPublicationByYear":170,"hindexLast5Year":135,"hindex":135},461,{"0":158,"2019":114,"2021":159,"2022":160,"2023":161,"2024":158,"2025":162},7,37,296,107,5,419,{"2021":59,"2022":59,"2023":165,"2024":166,"2025":167,"2026":168},71,126,171,41,0.91,{"2021":171,"2022":38,"2023":172,"2024":173,"2025":174},0.08,0.66,18,34.2,"JOURNAL",{"id":177,"createTime":178,"updateTime":179,"relativeEntities":180,"slug":181,"properties":182,"entityType":24,"verifyStatus":25,"verifyTime":193,"verifyNote":26,"syncStatus":28,"languages":194,"translateLanguages":26,"viewCount":36,"subjectFields":195,"manageAffiliations":196,"indexDatabases":197,"url":198,"thumbnailPath":26,"statistic":26,"gsStatistic":199,"type":175,"analyzePriority":26},"f8d0bf97-8d89-482e-b58c-2fc481a0b79b","2025-10-27T06:27:08.591+00:00","2026-06-18T23:33:41.667+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-v%C3%A0-C%C3%B4ng-ngh%E1%BB%87-nhi%E1%BB%87t-%C4%91%E1%BB%9Bi",{"country":183,"introduce":184,"gsId":186,"title":188,"issn":191},{"VOID":15},{"EN":185},"\u003Cp style=\"text-align:justify;\">&nbsp; &nbsp; &nbsp;Journal of Tropical Science and Engineering (JTSE) is a multidisciplinary scientific journal, licensed to operate as a print journal in 2012 and an electronic journal in 2024 (License No.1479\u002FGP-BTTTT dated August 20, 2012 and No.91\u002FGP-BTTTT dated April 9, 2024 issued by the Ministry of Information and Communications of Vietnam). The JTSE is headquartered in Hanoi.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">&nbsp; &nbsp; &nbsp; &nbsp; The JTSE is published every 3 months (4 issues\u002Fyear), publishing research results and overview articles in 3 groups of fields: Tropical Ecology and Environment; Chemistry and Material Sciences; Biomedicine and Pharmacy. In 2022, the JTSE registered the international identifier Digital Object Identifier (DOI): 10.58334\u002Fvrtc.jtst and assigned DOI codes to all articles of the journal. The members of the Editorial Board of the JTSE are prestigious scientists and leading scientists from Vietnam and many countries in the world. The JTSE has been recognized by the Vietnam State Council for Professorship to score scientific articles in Chemistry, Medicine and Biology with scores ranging from 0-0.75 points.\u003C\u002Fp>\u003Cp style=\"text-align:justify;\">&nbsp; &nbsp; &nbsp; Currently, the JTSE is building and perfecting a set of criteria and making efforts to join the List of prestigious&nbsp; international journals with a roadmap to enter Scopus and SCIE in the coming time.\u003C\u002Fp>",{"VOID":187},"MS2_GJQAAAAJ",{"VI":189,"EN":190},"Tạp chí Khoa học và Công nghệ nhiệt đới","Journal of Tropical Science and Engineering",{"VOID":192},"08667535","2025-10-27T06:27:25.058+00:00",[101,102],[],[],[],"https:\u002F\u002Ftapchikhcnnd.com.vn",{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":200,"totalPublicationByYear":201,"totalCitation":161,"totalCitationByYear":203,"totalCitationPerPublication":153,"totalCitationPerPublicationByYear":205,"hindexLast5Year":114,"hindex":114},481,{"0":115,"2020":115,"2021":115,"2022":114,"2024":115,"2025":202,"2026":115},474,{"2017":114,"2018":115,"2019":111,"2020":162,"2021":162,"2022":116,"2023":50,"2024":162,"2025":204,"2026":52},52,{"2020":162,"2021":162,"2022":162,"2024":162,"2025":206,"2026":52},0.11,{"id":208,"createTime":209,"updateTime":210,"relativeEntities":211,"slug":212,"properties":213,"entityType":24,"verifyStatus":25,"verifyTime":221,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":222,"subjectFields":223,"manageAffiliations":224,"indexDatabases":225,"url":226,"thumbnailPath":26,"statistic":227,"gsStatistic":276,"type":175,"analyzePriority":26},"a3d1e82a-57e2-40f9-940e-f5fa8b9ef64a","2023-06-01T07:11:26.039+00:00","2026-06-18T23:33:28.573+00:00",[],"VNU-Journal-of-Science-Earth-and-Environmental-Sciences",{"issn":214,"title":216,"country":218,"gsId":219},{"VOID":215},"26159279",{"EN":217},"VNU Journal of Science: Earth and Environmental Sciences",{"VOID":15},{"VOID":220},"UmXD8vEAAAAJ","2023-06-01T07:17:59.210+00:00",27,[],[],[],"https:\u002F\u002Fjs.vnu.edu.vn\u002FEES",{"impactFactor":36,"impactFactorByYear":228,"i10Index":234,"i10IndexLast5Year":36,"totalPublication":235,"totalPublicationByYear":236,"totalCitation":246,"totalCitationByYear":247,"totalCitationPerPublication":261,"totalCitationPerPublicationByYear":262,"hindexLast5Year":103,"hindex":103},{"2010":229,"2012":40,"2013":230,"2014":230,"2015":231,"2016":54,"2017":171,"2018":109,"2019":110,"2020":57,"2021":232,"2022":233,"2023":151,"2024":58},0.02,0.04,0.09,0.31,0.4,19,656,{"2008":237,"2009":238,"2010":239,"2011":238,"2012":240,"2013":241,"2014":239,"2015":242,"2016":243,"2017":244,"2018":245,"2019":165,"2020":125,"2021":168,"2022":125,"2023":222,"2024":111},23,24,22,28,25,20,146,29,78,1038,{"2008":248,"2009":249,"2010":250,"2011":251,"2012":252,"2013":253,"2014":254,"2015":255,"2016":256,"2017":257,"2018":161,"2019":258,"2020":259,"2021":29,"2022":260},119,64,66,86,38,73,59,31,129,39,97,53,26,1.58,{"2008":263,"2009":264,"2010":59,"2011":265,"2012":266,"2013":267,"2014":268,"2015":269,"2016":270,"2017":271,"2018":272,"2019":272,"2020":273,"2021":274,"2022":275},5.17,2.67,3.58,1.36,2.92,2.68,1.55,0.88,1.34,1.37,1.47,1.24,0.72,{"impactFactor":26,"impactFactorByYear":26,"i10Index":173,"i10IndexLast5Year":135,"totalPublication":277,"totalPublicationByYear":278,"totalCitation":279,"totalCitationByYear":280,"totalCitationPerPublication":288,"totalCitationPerPublicationByYear":289,"hindexLast5Year":158,"hindex":298},113,{"2007":114,"2008":103,"2009":173,"2010":116,"2011":51,"2012":239,"2013":103,"2014":162,"2015":53,"2016":135},616,{"2009":162,"2010":114,"2011":52,"2012":124,"2013":222,"2014":255,"2015":48,"2016":44,"2017":281,"2018":282,"2019":259,"2020":283,"2021":284,"2022":285,"2023":286,"2024":257,"2025":287,"2026":59},54,60,49,47,34,44,33,5.45,{"2009":290,"2010":291,"2011":292,"2012":293,"2013":294,"2014":295,"2015":296,"2016":297},0.28,0.2,0.6,0.77,2.25,6.2,3.91,9.67,14,{"id":300,"createTime":301,"updateTime":302,"relativeEntities":303,"slug":304,"properties":305,"entityType":24,"verifyStatus":25,"verifyTime":316,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":234,"subjectFields":317,"manageAffiliations":318,"indexDatabases":388,"url":389,"thumbnailPath":390,"statistic":391,"gsStatistic":409,"type":175,"analyzePriority":26},"a7166325-6c9e-4db3-8a59-7c879701a372","2023-07-31T04:28:49.231+00:00","2026-06-18T23:33:22.428+00:00",[],"VNU-Journal-of-Science-Policy-and-Management-Studies",{"country":306,"issn":307,"eissn":309,"title":311,"gsId":314},{"VOID":15},{"VOID":308},"26159295",{"VOID":310},"25881116",{"EN":312,"VI":313},"VNU Journal of Science: Policy and Management Studies","Tạp chí Nghiên cứu Chính sách và Quản lý",{"VOID":315},"xKW2E_cAAAAJ","2023-08-01T03:23:46.688+00:00",[],[319],{"id":320,"createTime":321,"updateTime":322,"relativeEntities":323,"slug":324,"properties":325,"entityType":98,"verifyStatus":25,"verifyTime":335,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":336,"url":337,"parentIds":338,"statistic":339},"12466116-8f60-4b01-8faf-2411483a0977","2023-05-30T09:37:38.472+00:00","2026-06-19T02:14:28.352+00:00",[],"Vietnam-National-University",{"country":326,"title":327,"abbreviation":330,"address":332},{"VOID":15},{"EN":328,"VI":329},"Vietnam National University, Hanoi","Đại học Quốc gia Hà Nội",{"VOID":331},"VNU",{"VI":333,"EN":334},"Số 144 Xuân Thủy, Phường Dịch Vọng Hậu, Quận Cầu Giấy, Hà Nội, Việt Nam","No. 144 Xuan Thuy Street, Dich Vong Hau Ward, Cau Giay District, Hanoi, Vietnam","2023-08-02T13:58:17.029+00:00",16,"http:\u002F\u002Fwww.vnu.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":340,"i10Index":285,"i10IndexLast5Year":162,"totalPublication":344,"totalPublicationByYear":345,"totalCitation":354,"totalCitationByYear":355,"totalCitationPerPublication":368,"totalCitationPerPublicationByYear":369,"hindexLast5Year":336,"hindex":336},{"2014":109,"2015":231,"2016":231,"2017":206,"2018":341,"2019":110,"2020":342,"2021":343,"2022":171,"2023":231,"2024":110,"2025":39},0.06,0.18,0.35,1247,{"2003":115,"2004":115,"2005":114,"2006":59,"2007":111,"2008":162,"2009":59,"2010":50,"2011":124,"2012":336,"2013":260,"2014":244,"2015":250,"2016":281,"2017":346,"2018":347,"2019":348,"2020":349,"2021":350,"2022":351,"2023":352,"2024":353,"2025":255,"2026":50},94,88,83,67,176,185,187,93,1644,{"2004":111,"2005":115,"2006":52,"2007":298,"2008":356,"2009":298,"2010":286,"2011":357,"2012":244,"2013":358,"2014":359,"2015":360,"2016":361,"2017":362,"2018":363,"2019":364,"2020":365,"2021":366,"2022":367,"2023":367,"2024":162},13,81,48,70,151,115,109,259,174,181,121,101,1.32,{"2004":111,"2005":370,"2006":59,"2007":371,"2008":372,"2009":373,"2010":374,"2011":375,"2012":376,"2013":377,"2014":378,"2015":379,"2016":380,"2017":381,"2018":382,"2019":383,"2020":384,"2021":385,"2022":386,"2023":387,"2024":109},0.5,3.5,2.6,4.67,5.5,4.76,1.81,1.85,2.41,2.29,2.13,1.16,2.94,2.1,2.7,0.69,0.55,0.54,[],"https:\u002F\u002Fjs.vnu.edu.vn\u002FPaM","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002Fa7166325-6c9e-4db3-8a59-7c879701a372\u002Fecfe83f4bcc60c7023ae04d8900fe0ac.jpg",{"impactFactor":36,"impactFactorByYear":392,"i10Index":111,"i10IndexLast5Year":36,"totalPublication":394,"totalPublicationByYear":395,"totalCitation":399,"totalCitationByYear":400,"totalCitationPerPublication":293,"totalCitationPerPublicationByYear":403,"hindexLast5Year":158,"hindex":158},{"2018":109,"2019":171,"2020":393,"2021":108,"2022":54,"2023":206,"2024":54},0.23,320,{"2015":50,"2016":239,"2017":286,"2018":396,"2019":397,"2020":159,"2021":398,"2022":168,"2023":79,"2024":255},30,35,40,247,{"2015":115,"2016":242,"2017":401,"2018":222,"2019":402,"2020":79,"2021":239,"2022":50,"2023":116},77,50,{"2015":404,"2016":169,"2017":405,"2018":406,"2019":407,"2020":408,"2021":386,"2022":291,"2023":232},0.12,1.75,0.9,1.43,0.86,{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":103,"totalPublicationByYear":410,"totalCitation":234,"totalCitationByYear":411,"totalCitationPerPublication":261,"totalCitationPerPublicationByYear":412,"hindexLast5Year":114,"hindex":59},{"2015":114,"2016":116},{"2016":115,"2017":114,"2018":114,"2019":59,"2020":114,"2021":59,"2022":114,"2023":114,"2024":115,"2026":115},{"2016":108},{"id":414,"createTime":415,"updateTime":416,"relativeEntities":417,"slug":418,"properties":419,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":238,"subjectFields":428,"manageAffiliations":429,"indexDatabases":430,"url":431,"thumbnailPath":26,"statistic":432,"gsStatistic":438,"type":175,"analyzePriority":26},"16e65a3f-d274-47dd-8691-56d76eb58c3d","2023-05-30T09:10:06.062+00:00","2026-06-18T23:33:17.679+00:00",[],"Vietnam-Journal-of-Otorhinolaryngology-Head-and-Neck-Surgery",{"country":420,"issn":421,"title":423,"gsId":426},{"VOID":15},{"VOID":422},"18593704",{"EN":424,"VI":425},"Vietnam Journal of Otorhinolaryngology - Head and Neck Surgery","Tạp chí Tai Mũi Họng Việt Nam",{"VOID":427},"L78B_eIAAAAJ",[],[],[],"https:\u002F\u002Ftapchitaimuihong.vn\u002Findex.php\u002Ftmh",{"impactFactor":36,"impactFactorByYear":433,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":434,"totalPublicationByYear":435,"totalCitation":111,"totalCitationByYear":436,"totalCitationPerPublication":230,"totalCitationPerPublicationByYear":437,"hindexLast5Year":115,"hindex":115},{"2024":229},95,{"2022":52,"2023":286,"2024":255,"2025":53},{"2023":111},{"2023":231},{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":240,"totalPublicationByYear":439,"totalCitation":234,"totalCitationByYear":440,"totalCitationPerPublication":441,"totalCitationPerPublicationByYear":442,"hindexLast5Year":114,"hindex":114},{"2023":53,"2024":116,"2025":135,"2026":115},{"2024":59,"2025":298,"2026":114},0.68,{"2024":443,"2025":444,"2026":114},0.3,2.33,{"id":446,"createTime":447,"updateTime":448,"relativeEntities":449,"slug":450,"properties":451,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":396,"subjectFields":460,"manageAffiliations":461,"indexDatabases":462,"url":463,"thumbnailPath":464,"statistic":465,"gsStatistic":472,"type":175,"analyzePriority":26},"25988add-c322-4eda-afda-63b1559bb824","2023-04-07T03:49:55.817+00:00","2026-06-18T23:32:23.776+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Y%20-%20D%C6%B0%E1%BB%A3c%20h%E1%BB%8Dc%20qu%C3%A2n%20s%E1%BB%B1",{"country":452,"issn":453,"title":455,"gsId":458},{"VOID":15},{"VOID":454},"18590748",{"EN":456,"VI":457},"Journal of Military Pharmaco-medicine","Tạp chí Y - Dược học quân sự",{"VOID":459},"_pmQ8IEAAAAJ",[],[],[],"https:\u002F\u002Fjmpm.vn\u002Findex.php\u002Fjmpm","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F25988add-c322-4eda-afda-63b1559bb824\u002F09c6bc42157cf5ece95edc971ccddb52.jpg",{"impactFactor":36,"impactFactorByYear":466,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":467,"totalPublicationByYear":468,"totalCitation":135,"totalCitationByYear":470,"totalCitationPerPublication":38,"totalCitationPerPublicationByYear":471,"hindexLast5Year":115,"hindex":115},{"2023":229,"2024":38},475,{"2022":168,"2023":365,"2024":469,"2025":124},236,{"2022":114,"2023":111},{"2022":109,"2023":229},{"impactFactor":26,"impactFactorByYear":26,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":277,"totalPublicationByYear":473,"totalCitation":401,"totalCitationByYear":474,"totalCitationPerPublication":441,"totalCitationPerPublicationByYear":475,"hindexLast5Year":59,"hindex":59},{"2015":115,"2018":114,"2019":115,"2020":115,"2021":59,"2022":103,"2023":159,"2024":287,"2025":237},{"2020":115,"2021":115,"2022":115,"2023":52,"2024":237,"2025":79,"2026":116},{"2020":115,"2021":476,"2022":171,"2023":477,"2024":478,"2025":479},0.33,0.24,0.7,1.39,{"id":481,"createTime":482,"updateTime":483,"relativeEntities":484,"slug":485,"properties":486,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":496,"translateLanguages":26,"viewCount":45,"subjectFields":497,"manageAffiliations":498,"indexDatabases":525,"url":526,"thumbnailPath":527,"statistic":528,"gsStatistic":26,"type":26,"analyzePriority":26},"2b8d7b12-2d20-4777-be98-077f44f03c69","2023-09-07T07:40:58.286+00:00","2025-07-13T21:21:00.542+00:00",[],"VNU-Journal-of-Social-Sciences-and-Humanities",{"country":487,"issn":488,"introduce":490,"title":493},{"VOID":15},{"VOID":489},"23541172",{"EN":491,"VI":492},"{\"ops\":[{\"insert\":\"VNU Journal of Social Sciences and Humanities (ISSN 2354-1172) is a double-blind peer-reviewed journal published by University of Social Sciences and Humanities, Vietnam National University, Hanoi, Vietnam, under the publication permit no. 155\u002FGP-BTTTT, issued on 11\"},{\"attributes\":{\"script\":\"super\"},\"insert\":\"th \"},{\"insert\":\"May, 2015 by Ministry of Information and Communications. The journal publishes four Vietnamese issues and two English issues per year.\\nCurrently, there are 35 reputable professors in the editorial board. The main objectives of the journal include: providing an intellectual platform for Vietnamese and international scholars; promoting interdisciplinary studies in social sciences and humanities; becoming the leading journal in social sciences and humanities in Vietnam; being indexed by worldwide databases and having academic recognition internationally in the near future.\\nThe journal is currently indexed by Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services and Vietnam National University’s digital archive.\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Journal of Social Sciences and Humanities-Vietnam\"},{\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"ISSN 2354-1172, email: tapchikhxhnv@gmail.com, tckhxhnv@vnu.edu.vn\"},{\"insert\":\"\\n\"}]}","{\"ops\":[{\"insert\":\"Được thành lập ngày 31\u002F8\u002F2015 (giấy phép hoạt động số 155\u002FGP-BVHTT ngày 11 tháng 5 năm 2015 của Bộ Thông tin và Truyền thông, mã số tiêu chuẩn quốc tế ISSN 2354-1172), Tạp chí Khoa học Xã hội và Nhân văn (Journal of Social Sciences and Humanities) là ấn phẩm khoa học chính thức, duy nhất của Trường Đại học Khoa học Xã hội và Nhân văn, ĐHQG Hà Nội, phát triển và kế thừa Chuyên san Khoa học Xã hội và Nhân văn, Tạp chí Khoa học, ĐHQG Hà Nội.\\nTạp chí xuất bản định kỳ (04 số tiếng Việt\u002Fnăm và 02 số tiếng Anh\u002Fnăm), có nhiệm vụ \"},{\"attributes\":{\"italic\":true},\"insert\":\"công bố, giới thiệu các công trình nghiên cứu khoa học khoa học xã hội và nhân văn của các tác giả là các nhà khoa học trong và ngoài nước, phục vụ giảng dạy, học tập và nghiên cứu khoa học\"},{\"insert\":\". Hội đồng biên tập của Tạp chí hiện bao gồm 33 nhà khoa học có uy tín trong nước và quốc tế. Tạp chí tập trung và ưu tiên đăng tải những bài báo theo định hướng của tinh thần cởi mở, sáng tạo, nhanh chóng vươn lên để tiếp cận và sánh ngang với các tạp chí có uy tín hàng đầu của khu vực và trên thế giới. Nội dung chính của Tạp chí bao gồm các Bài nghiên cứu (khoảng 6000 đến 15000 từ), các bài điểm sách, thông tin khoa học (khoảng 300 đến 1500 từ) được trình bày theo đúng cấu trúc và chuẩn mực của một tạp chí khoa học.\\nCác bài viết của Tạp chí hiện đang được trích dẫn bởi Google Scholar, WorldCat, Open Archives, Cosmos Impact Factor, Advanced Sciences Index, Scientific Indexing Services, CrossRef, EBSCO Information Services.\\nMọi thông tin xin liên hệ: \"},{\"attributes\":{\"italic\":true},\"insert\":\"Phòng Tạp chí, 701 - E, Trường Đại học Khoa học Xã hội và Nhân văn, 336 Nguyễn Trãi, Thanh Xuân, Hà Nội. ĐT: 024.35581984; email: tckhxhnv@vnu.edu.vn \"},{\"insert\":\"hoặc \"},{\"attributes\":{\"italic\":true},\"insert\":\"tapchikhxhnv@gmail.com \"},{\"insert\":\"\\n\"}]}",{"EN":494,"VI":495},"VNU Journal of Social Sciences and Humanities","Tạp chí Khoa học Xã hội và Nhân văn",[101,102],[],[499],{"id":500,"createTime":501,"updateTime":502,"relativeEntities":503,"slug":504,"properties":505,"entityType":98,"verifyStatus":25,"verifyTime":509,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":222,"url":26,"parentIds":510,"statistic":511},"8b6e349b-0daf-4895-9c3f-85f30f1bfd42","2023-07-31T12:55:58.430+00:00","2026-06-19T02:30:07.899+00:00",[],"Tr%C6%B0%E1%BB%9Dng-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Khoa-h%E1%BB%8Dc-X%C3%A3-h%E1%BB%99i-v%C3%A0-Nh%C3%A2n-v%C4%83n-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-H%C3%A0-N%E1%BB%99i",{"title":506},{"EN":507,"VI":508},"VNU University of Social Sciences and Humanities","Trường Đại học Khoa học Xã hội và Nhân văn, Đại học Quốc gia Hà Nội","2023-08-02T15:28:49.057+00:00",[],{"impactFactor":36,"impactFactorByYear":512,"i10Index":59,"i10IndexLast5Year":115,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":518,"totalCitationByYear":519,"totalCitationPerPublication":520,"totalCitationPerPublicationByYear":521,"hindexLast5Year":162,"hindex":162},{"2016":229,"2017":230,"2018":229,"2021":230,"2022":58,"2023":513,"2024":38},0.15,365,{"2013":115,"2014":158,"2015":125,"2016":252,"2017":44,"2018":516,"2019":286,"2020":396,"2021":259,"2022":517,"2023":396,"2024":115,"2025":59,"2026":115},21,42,169,{"2015":283,"2016":135,"2017":52,"2018":50,"2019":298,"2020":53,"2021":359,"2022":115,"2023":115},0.46,{"2015":266,"2016":57,"2017":57,"2018":522,"2019":523,"2020":524,"2021":368,"2022":229,"2023":39},0.38,0.32,0.37,[],"http:\u002F\u002Fjournal.ussh.vnu.edu.vn\u002Findex.php\u002Fvjossh","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F2b8d7b12-2d20-4777-be98-077f44f03c69\u002F0bd0751202944a4b4165b482e6e623e4.png",{"impactFactor":36,"impactFactorByYear":529,"i10Index":162,"i10IndexLast5Year":115,"totalPublication":530,"totalPublicationByYear":531,"totalCitation":537,"totalCitationByYear":538,"totalCitationPerPublication":343,"totalCitationPerPublicationByYear":540,"hindexLast5Year":135,"hindex":135},{"2016":341,"2017":39,"2018":229,"2019":38,"2020":110,"2021":231,"2022":231,"2023":341,"2024":39},764,{"2015":255,"2016":245,"2017":532,"2018":259,"2019":533,"2020":534,"2021":535,"2022":536,"2023":534,"2024":254,"2025":50},111,106,68,92,89,265,{"2015":539,"2016":241,"2017":168,"2018":51,"2019":349,"2020":260,"2021":244,"2022":298,"2023":114},46,{"2015":541,"2016":523,"2017":524,"2018":290,"2019":542,"2020":522,"2021":523,"2022":57,"2023":39},1.48,0.63,{"id":544,"createTime":545,"updateTime":546,"relativeEntities":547,"slug":548,"properties":549,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":558,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":50,"subjectFields":559,"manageAffiliations":560,"indexDatabases":561,"url":562,"thumbnailPath":563,"statistic":564,"gsStatistic":26,"type":26,"analyzePriority":26},"6ec01bd0-15c0-469a-86ac-41339076ae0a","2023-08-10T07:08:33.153+00:00","2026-01-31T21:19:06.362+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Da-li%E1%BB%85u-h%E1%BB%8Dc-Vi%E1%BB%87t-Nam",{"country":550,"issn":551,"introduce":553,"title":555},{"VOID":15},{"VOID":552},"18594824",{"VI":554},"{\"ops\":[{\"insert\":\"Tạp chí “Da liễu học Việt Nam” (Tiếng Anh: Vietnamese Journal of Dermatology and Venereology) thuộc Hội Da liễu Việt Nam, xuất bản 4 số mỗi năm bằng tiếng Việt hoặc tiếng Anh.\\nTạp chí Da liễu học Việt Nam hoạt động với mục đích, tôn chỉ là phổ biến, trao đổi thông tin trong lĩnh vực chuyên ngành da liễu; đăng tải các công trình nghiên cứu khoa học; chuyển giao công nghệ - kinh tế và khoa học kỹ thuật liên quan đến lĩnh vực da liễu.\\nPhạm vi của tạp chí là tất cả các bài báo khoa học, bài tổng quan, giới thiệu ca lâm sàng, … có liên quan tới chuyên ngành da liễu trong và ngoài nước. Tạp chí công bố các công trình nghiên cứu liên quan đến mô hình bệnh tật, các phương pháp chẩn đoán, điều trị, dự phòng và phục hồi chức năng các bệnh thuộc chuyên ngành da liễu. Ngoài ra, tạp chí còn đăng tải các bài tổng quan, cập nhật thông tin, kiến thức, hướng dẫn chẩn đoán, điều trị trong chuyên ngành da liễu trong nước và quốc tế; đăng tải các bài ca lâm sàng đặc biệt trong chuyên ngành da liễu.\\nTạp chí Da liễu học Việt Nam được biết tới là một tạp chí chuyên ngành có uy tín trong lĩnh vực da liễu. Các bài báo về nghiên cứu khoa học đăng trong Tạp chí được bình duyệt một cách nghiêm ngặt bởi ít nhất 2 chuyên gia. Hội đồng biên tập tạp chí bao gồm các nhà khoa học có uy tín (Giáo sư, Phó Giáo sư, Tiến sĩ, Bác sĩ…) trong chuyên ngành da liễu nhằm đảm bảo chất lượng và tính khách quan, khoa học cho các bài viết đăng trên Tạp chí.\\n\"}]}",{"EN":556,"VI":557},"Vietnamese Journal of Dermatology and Venereology","Tạp chí Da liễu học Việt Nam","Admin Import",[],[],[],"https:\u002F\u002Fvjdv.vn\u002Findex.php\u002Fvjdv","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F6ec01bd0-15c0-469a-86ac-41339076ae0a\u002F3cbc81720e58429dc7b1c4d7ab1935ca.jpg",{"impactFactor":36,"impactFactorByYear":565,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":566,"totalPublicationByYear":567,"totalCitation":116,"totalCitationByYear":570,"totalCitationPerPublication":109,"totalCitationPerPublicationByYear":571,"hindexLast5Year":115,"hindex":115},{"2023":38,"2024":230},182,{"2022":568,"2023":45,"2024":569},69,56,{"2022":52,"2023":115},{"2022":40,"2023":229},{"id":573,"createTime":574,"updateTime":575,"relativeEntities":576,"slug":577,"properties":578,"entityType":24,"verifyStatus":25,"verifyTime":26,"verifyNote":27,"syncStatus":28,"languages":587,"translateLanguages":26,"viewCount":283,"subjectFields":588,"manageAffiliations":589,"indexDatabases":647,"url":648,"thumbnailPath":649,"statistic":650,"gsStatistic":26,"type":26,"analyzePriority":26},"19221551-7519-47ff-a892-331d1139c64b","2023-09-12T07:03:05.744+00:00","2026-01-24T20:54:40.144+00:00",[],"T%E1%BA%A1p-ch%C3%AD-Khoa-h%E1%BB%8Dc-S%E1%BB%A9c-kho%E1%BA%BB-%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-Th%C3%A0nh-ph%E1%BB%91-H%E1%BB%93-Ch%C3%AD-Minh",{"country":579,"issn":580,"introduce":582,"title":584},{"VOID":15},{"VOID":581},"27349446",{"EN":583},"{\"ops\":[{\"attributes\":{\"bold\":true},\"insert\":\"1. History\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"Science and Technology Development Journal\"},{\"insert\":\" (STDJ) (ISSN 2734-9446), Vietnam National University - Ho Chi Minh City (VNU-HCM) was established in 1997. And the first issue was published in January 1998 with ISSN 1859-0128. Since then, STDJ has become the most important scientific forum of scientists from VNU-HCM as well as other universities. The magazine has undergone 20 years of development and has become a bridge for scientific exchanges, as well as enriching reference materials for the faculty, doctoral students, students of VNU-HCM in particular and other universities, institutes...\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Science and Technology Development Journal - Health Sciences (STDJ-HS) is a subjournal of Science and Technology Development Journal since 2020.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\" \"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"attributes\":{\"bold\":true},\"insert\":\"2. Focus and Scope\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Publishing articles with contents on healthcare, research projects in the field of health, advanced directions in health education and management. Therefore, STDJ-HS will accept articles from doctors, administrators, teachers, researchers, graduate students and fellows. The authors will be responsible for the accuracy of the data, opinions, opinions and material cited in the article.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"Facilitating the exchange of scientific and technological information and act as a bridge between theory and practice in the community of educators, scientists, managers, policy makers and enterprises in and out of the country.\"},{\"attributes\":{\"align\":\"justify\"},\"insert\":\"\\n\"},{\"insert\":\"\\n\"}]}",{"EN":585,"VI":586},"VNUHCM JOURNAL OF HEALTH SCIENCES","Tạp chí Khoa học Sức khoẻ Đại học Quốc gia Thành phố Hồ Chí Minh",[101,102],[],[590],{"id":591,"createTime":592,"updateTime":593,"relativeEntities":594,"slug":595,"properties":596,"entityType":98,"verifyStatus":25,"verifyTime":606,"verifyNote":26,"syncStatus":28,"languages":607,"translateLanguages":26,"viewCount":608,"url":609,"parentIds":610,"statistic":611},"fc4c2560-868c-4677-acb1-8686bef88727","2023-06-26T04:48:23.774+00:00","2026-06-19T01:46:17.248+00:00",[],"%C4%90%E1%BA%A1i-h%E1%BB%8Dc-Qu%E1%BB%91c-gia-Th%C3%A0nh-ph%E1%BB%91-H%E1%BB%93-Ch%C3%AD-Minh",{"country":597,"title":598,"abbreviation":601,"address":603},{"VOID":15},{"EN":599,"VI":600},"Vietnam National University Ho Chi Minh City","Đại học Quốc gia Thành phố Hồ Chí Minh",{"VOID":602},"VNUHCM",{"VI":604,"EN":605},"khu phố 6, Phường Linh Trung, Thành phố Thủ Đức, Thành phố Hồ Chí Minh, Việt Nam","Quarter 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam","2023-08-16T14:13:07.134+00:00",[101,102],45,"https:\u002F\u002Fvnuhcm.edu.vn\u002F",[],{"impactFactor":36,"impactFactorByYear":612,"i10Index":285,"i10IndexLast5Year":51,"totalPublication":613,"totalPublicationByYear":614,"totalCitation":624,"totalCitationByYear":625,"totalCitationPerPublication":634,"totalCitationPerPublicationByYear":635,"hindexLast5Year":124,"hindex":124},{"2014":36,"2015":38,"2016":109,"2017":39,"2018":229,"2019":38,"2020":110,"2021":171,"2022":110,"2023":110,"2024":171,"2025":229},3708,{"2005":115,"2006":115,"2007":115,"2008":135,"2009":111,"2010":53,"2011":52,"2012":568,"2013":615,"2014":351,"2015":616,"2016":469,"2017":617,"2018":127,"2019":618,"2020":619,"2021":620,"2022":621,"2023":622,"2024":623,"2025":159,"2026":50},164,266,177,226,603,931,314,246,74,2399,{"2006":115,"2008":50,"2010":162,"2011":242,"2012":222,"2013":43,"2014":626,"2015":627,"2016":628,"2017":629,"2018":258,"2019":630,"2020":631,"2021":632,"2022":633,"2023":353,"2024":115},250,124,157,162,152,385,559,128,0.65,{"2006":115,"2008":636,"2010":637,"2011":638,"2012":639,"2013":522,"2014":640,"2015":641,"2016":642,"2017":643,"2018":644,"2019":642,"2020":645,"2021":292,"2022":646,"2023":522,"2024":38},1.33,0.45,2.22,0.39,1.35,0.47,0.67,0.92,0.73,0.64,0.41,[],"http:\u002F\u002Fstdjhs.scienceandtechnology.com.vn\u002Findex.php\u002Fstdjhs","\u002Fapi\u002Fpublic\u002Ffile\u002Fpublisher\u002F19221551-7519-47ff-a892-331d1139c64b\u002F2e10768b7d1e380c36a25ed0c714dd7e.png",{"impactFactor":36,"impactFactorByYear":651,"i10Index":36,"i10IndexLast5Year":36,"totalPublication":652,"totalPublicationByYear":653,"totalCitation":516,"totalCitationByYear":654,"totalCitationPerPublication":151,"totalCitationPerPublicationByYear":655,"hindexLast5Year":59,"hindex":59},{"2022":57,"2023":108,"2024":39},79,{"2020":116,"2021":240,"2022":239,"2023":52,"2024":162,"2025":162},{"2020":59,"2021":51,"2022":59},{"2020":443,"2021":387,"2022":54},{"code":657,"data":658,"meta":26},"SUCCESS",{"id":659,"createTime":660,"updateTime":661,"relativeEntities":662,"slug":663,"properties":664,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":675,"manageAffiliations":692,"indexDatabases":713,"url":755,"thumbnailPath":26,"statistic":756,"gsStatistic":26,"type":26,"analyzePriority":26},"fb2b19f0-d2c3-49ba-8ecf-940b8beaa98b","2023-05-29T11:10:05.749+00:00","2025-11-21T09:54:55.620+00:00",[],"Nature-Medicine",{"country":665,"issn":667,"introduce":669,"eissn":671,"title":673},{"VOID":666},"GB",{"VOID":668},"1546170X",{"EN":670},"Nature Medicine publishes research that addresses the needs and goals of contemporary medicine. Original research ranges from new concepts in human biology and disease pathogenesis to robust preclinical bases for new therapeutic modalities and drug development to all phases of clinical work, as well as innovative technologies aimed at improving human health. Current areas of interest also include, but are not limited to: -Gene and cell therapies -Clinical genomics -Regenerative medicine -High-definition medicine -Effects of the environment in human health -Artificial intelligence in health care -Smart wearable devices -Early disease diagnosis -Microbiome -Aging Nature Medicine also publishes Reviews, Perspectives and other content commissioned from leading scientists in their fields to provide expert and contextualized views of the latest research driving the progress of medicine. The News section is editorially independent and provides topical and timely reporting of upcoming trends affecting medicine, researchers and the general audience.",{"VOID":672},"10788956",{"EN":674},"Nature Medicine",[676,684],{"id":677,"createTime":678,"updateTime":679,"relativeEntities":680,"label":681,"description":683,"parentId":26,"standard":26,"scholarHubFieldId":26},"97cdf9a1-b6ca-4a4d-aa74-b136947bc142","2023-05-29T10:24:03.260+00:00","2023-11-21T06:49:46.360+00:00",[],{"EN":682},"Biochemistry, Genetics and Molecular Biology (miscellaneous)",{},{"id":685,"createTime":686,"updateTime":687,"relativeEntities":688,"label":689,"description":691,"parentId":26,"standard":26,"scholarHubFieldId":26},"0254e3e5-c28d-4a33-83da-81bc94d29ffd","2023-05-29T10:24:00.931+00:00","2023-11-21T07:56:41.438+00:00",[],{"EN":690},"Medicine (miscellaneous)",{},[693,703],{"id":694,"createTime":695,"updateTime":696,"relativeEntities":697,"slug":698,"properties":699,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":135,"url":26,"parentIds":702,"statistic":26},"ae54b068-a7dd-4746-b752-b7b24439de47","2023-05-29T10:24:12.391+00:00","2025-11-21T09:53:50.486+00:00",[],"Nature-Publishing-Group",{"title":700},{"EN":701},"Nature Publishing Group",[],{"id":704,"createTime":705,"updateTime":706,"relativeEntities":707,"slug":708,"properties":709,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"url":26,"parentIds":712,"statistic":26},"b134a19f-d595-49fa-bd59-70d90fa3a3b3","2023-05-29T12:35:12.827+00:00","2024-02-20T05:01:33.021+00:00",[],"NATURE-PORTFOLIO",{"title":710},{"EN":711},"NATURE PORTFOLIO",[],[714,735],{"id":715,"indexDatabase":716,"url":730,"indexYears":26,"academicFieldIds":731,"indexDatabaseRanking":26},"5bda0fb7-8c21-4293-bbbd-ef850efe4caf",{"id":717,"createTime":718,"updateTime":719,"relativeEntities":720,"label":721,"description":723,"key":726,"publicationTags":727,"standard":26},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":722,"VI":722},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":724,"EN":725},"Cơ sở dữ liệu SCIE","SCIE database","scie",[728,729],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1078-8956",[732,733,734],"49fc4fe4-851c-4795-9e04-8a0288bc0b8b","10e9c71e-2256-419c-bdd2-a39e436e76e3","8eb75d88-0c7a-497c-a346-e729afc75040",{"id":736,"indexDatabase":737,"url":749,"indexYears":750,"academicFieldIds":751,"indexDatabaseRanking":754},"0be52cda-1edc-480e-9d45-b485ea2f08dc",{"id":738,"createTime":739,"updateTime":740,"relativeEntities":741,"label":742,"description":744,"key":746,"publicationTags":747,"standard":26},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":743,"VI":743},"Scopus - Elsevier",{"EN":743,"VI":745},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[748],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F15819","1995-2025",[752,753],"8e5f5f89-df86-44a7-bb58-d8bad424ac5f","e89cebf4-fecf-4b74-8ab4-88fca891e4c2","SCOPUS__Q1","https:\u002F\u002Fwww.nature.com\u002Fnm\u002F",{"impactFactor":36,"impactFactorByYear":757,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":771,"totalCitation":772,"totalCitationByYear":773,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":804,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},41.35,53.58,60.42,46.23,88.36,37.5,90.5,167.53,513.17,415.68,229.7,272,277,{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},253450,{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},18394,6529,17794,6297,15818,11742,16314,15083,8129,5768,5098,9881,4391,6640,5497,2491,10569,5603,12806,4308,12251,471,108,12890,6883,22767,7846,933,149,914.98,{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},1839.4,725.44,1112.12,699.67,1054.53,903.23,1359.5,887.24,739,576.8,463.45,760.08,627.29,603.64,610.78,355.86,813,431,1829.43,359,1225.1,1171.82,1147.17,1897.25,1120.86,311,217,{"meta":833,"data":835},{"total":834},"729",[836,1502,1861,2120,3027,3335,3634,4303,4867,5456],{"id":837,"createTime":838,"updateTime":838,"relativeEntities":839,"slug":840,"properties":841,"entityType":854,"verifyStatus":25,"verifyTime":838,"verifyNote":855,"syncStatus":28,"languages":856,"translateLanguages":26,"viewCount":36,"primaryUrl":857,"fullTextUrl":26,"authors":858,"publicationType":918,"publisherRelationship":919,"citationCount":957,"citationInfo":958,"publishDate":970,"publishYear":971,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":972,"isForceReanalyzing":1501},"3d8148c3-93a1-40d3-8d54-4d5d29bc9bf3","2024-09-25T08:46:25.384+00:00",[],"The-biology-of-VEGF-and-its-receptors",{"mag":842,"keywords":844,"openalex":845,"abstract":847,"title":848,"pm":850,"doi":852},{"VOID":843},"2000292756",{},{"VOID":846},"W2000292756",{},{"EN":849},"The biology of VEGF and its receptors",{"VOID":851},"12778165",{"VOID":853},"10.1038\u002Fnm0603-669","PUBLICATION","Auto Verify",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm0603-669",[859,881,901],{"id":860,"sortIndex":36,"researcher":26,"roles":861,"affiliations":862,"properties":874},"d040fda5-1a3a-4df3-a4f7-a61efb5a9750",[],[863],{"id":864,"sortIndex":36,"affiliation":865,"properties":26},"31d37ca6-f557-4219-9925-b72fc9620c78",{"id":866,"createTime":867,"updateTime":868,"relativeEntities":869,"slug":870,"properties":871,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"44b0a914-9dfa-4ad6-98d5-07a68d893525","2024-01-20T09:58:35.306+00:00","2024-09-25T08:46:25.404+00:00",[],"Department-of-Molecular-Oncology-Genentech-Inc-1-DNA-Way-South-San-Francisco-California-94080-USA",{"title":872},{"VI":873},"Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA",{"openalex":875,"orcid":877,"title":879},{"VOID":876},"A5101652233",{"VOID":878},"https:\u002F\u002Forcid.org\u002F0000-0002-7029-6375",{"EN":880},"Napoleone Ferrara",{"id":882,"sortIndex":114,"researcher":26,"roles":883,"affiliations":884,"properties":896},"83938a6b-ce26-45d8-a832-d3642956ce98",[],[885],{"id":886,"sortIndex":36,"affiliation":887,"properties":26},"65eef257-81e9-4032-9a23-e7211d1dca9b",{"id":888,"createTime":889,"updateTime":890,"relativeEntities":891,"slug":892,"properties":893,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"c89ca7a6-7969-4045-8310-dc4f72619a10","2024-02-09T12:59:05.376+00:00","2024-09-25T08:46:25.414+00:00",[],"Department-of-Molecular-Oncology-Genentech-Inc-South-San-Francisco-USA",{"title":894},{"VI":895},"Department of Molecular Oncology, Genentech Inc., South San Francisco, USA",{"openalex":897,"title":899},{"VOID":898},"A5086276703",{"EN":900},"Jennifer LeCouter",{"id":902,"sortIndex":115,"researcher":26,"roles":903,"affiliations":904,"properties":911},"67d0cc9d-9966-409f-a428-86c41bf9a479",[],[905],{"id":906,"sortIndex":36,"affiliation":907,"properties":26},"828f6f2d-2b01-4dc2-94af-bd598b6ba0b5",{"id":888,"createTime":889,"updateTime":890,"relativeEntities":908,"slug":892,"properties":909,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":910},{"VI":895},{"openalex":912,"orcid":914,"title":916},{"VOID":913},"A5052067361",{"VOID":915},"https:\u002F\u002Forcid.org\u002F0000-0002-0741-9328",{"EN":917},"Hans‐Peter Gerber","ARTICLE",{"url":26,"publisher":920,"properties":950},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":921,"slug":663,"properties":922,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":928,"manageAffiliations":929,"indexDatabases":930,"url":755,"thumbnailPath":26,"statistic":945,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":923,"issn":924,"introduce":925,"eissn":926,"title":927},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[931,938],{"id":736,"indexDatabase":932,"url":749,"indexYears":750,"academicFieldIds":937,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":933,"label":934,"description":935,"key":746,"publicationTags":936,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":939,"url":730,"indexYears":26,"academicFieldIds":944,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":940,"label":941,"description":942,"key":726,"publicationTags":943,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":946,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":947,"totalCitation":772,"totalCitationByYear":948,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":949,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":951,"pages":953,"issue":955},{"VOID":952},"9",{"VOID":954},"669-676",{"VOID":956},"6",9139,{"total":957,"publishYear":26,"statisticByYear":959},{"2012":619,"2013":147,"2014":960,"2015":961,"2016":962,"2017":963,"2018":964,"2019":965,"2020":966,"2021":967,"2022":968,"2023":969,"2024":351},552,510,455,452,400,415,384,391,354,309,"2003-06-01",2003,[973,977,981,985,989,993,997,1001,1005,1009,1013,1017,1020,1024,1028,1032,1036,1040,1044,1048,1052,1056,1060,1064,1068,1071,1075,1079,1082,1086,1090,1094,1098,1102,1106,1110,1114,1118,1122,1126,1130,1133,1137,1141,1145,1149,1153,1157,1160,1163,1167,1171,1175,1179,1183,1187,1191,1195,1199,1203,1207,1211,1215,1219,1223,1227,1231,1235,1239,1243,1247,1251,1255,1259,1262,1266,1270,1274,1278,1282,1286,1290,1294,1298,1302,1306,1309,1313,1317,1321,1324,1328,1332,1336,1339,1343,1347,1351,1355,1359,1362,1365,1369,1373,1377,1380,1383,1386,1389,1393,1397,1400,1404,1408,1412,1415,1419,1423,1427,1431,1434,1438,1442,1446,1450,1454,1458,1462,1466,1470,1473,1477,1481,1485,1489,1493,1497],{"id":26,"text":974,"url":26,"identifiers":975},"Folkman, J. & Shing, Y. Angiogenesis. J. Biol. Chem. 267, 10931–10934 (1992).",{"doi":976},"10.1016\u002FS0021-9258(19)49853-0",{"id":26,"text":978,"url":26,"identifiers":979},"Yancopoulos, G.D. et al. Vascular-specific growth factors and blood vessel formation. Nature 407, 242–248 (2000).",{"doi":980},"10.1038\u002F35025215",{"id":26,"text":982,"url":26,"identifiers":983},"Ferrara, N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev. Cancer 2, 795–803 (2002).",{"doi":984},"10.1038\u002Fnrc909",{"id":26,"text":986,"url":26,"identifiers":987},"Ferrara, N. & Alitalo, K. Clinical applications of angiogenic growth factors and their inhibitors. Nat. Med. 5, 1359–1364 (1999).",{"doi":988},"10.1038\u002F70928",{"id":26,"text":990,"url":26,"identifiers":991},"Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 6, 389–395 (2000).",{"doi":992},"10.1038\u002F74651",{"id":26,"text":994,"url":26,"identifiers":995},"Ferrara, N. & Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4–25 (1997).",{"doi":996},"10.1210\u002Fedrv.18.1.0287",{"id":26,"text":998,"url":26,"identifiers":999},"Neufeld, G., Cohen, T., Gengrinovitch, S. & Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9–22 (1999).",{"doi":1000},"10.1096\u002Ffasebj.13.1.9",{"id":26,"text":1002,"url":26,"identifiers":1003},"Karkkainen, M.J., Makinen, T. & Alitalo, K. Lymphatic endothelium: a new frontier of metastasis research. Nat. Cell Biol. 4, E2–E5 (2002).",{"doi":1004},"10.1038\u002Fncb0102-e2",{"id":26,"text":1006,"url":26,"identifiers":1007},"Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V. & Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306–1309 (1989).",{"doi":1008},"10.1126\u002Fscience.2479986",{"id":26,"text":1010,"url":26,"identifiers":1011},"Plouet, J., Schilling, J. & Gospodarowicz, D. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT20 cells. EMBO J. 8, 3801–3808 (1989).",{"doi":1012},"10.1002\u002Fj.1460-2075.1989.tb08557.x",{"id":26,"text":1014,"url":26,"identifiers":1015},"Nagy, J.A. et al. Vascular permeability factor\u002Fvascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J. Exp. Med. 196, 1497–1506 (2002).",{"doi":1016},"10.1084\u002Fjem.20021244",{"id":26,"text":1018,"url":26,"identifiers":1019},"Matsumoto, T. & Claesson-Welsh, L. VEGF receptor signal transduction. Science STKE 112 (RE21), 1–17 (2001).",{},{"id":26,"text":1021,"url":26,"identifiers":1022},"Compernolle, V. et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med. 8, 702–710 (2002).",{"doi":1023},"10.1038\u002Fnm721",{"id":26,"text":1025,"url":26,"identifiers":1026},"Gerber, H.P., Dixit, V. & Ferrara, N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 273, 13313–13316 (1998).",{"doi":1027},"10.1074\u002Fjbc.273.21.13313",{"id":26,"text":1029,"url":26,"identifiers":1030},"Gerber, H.P. et al. VEGF regulates endothelial cell survival by the PI3-kinase\u002FAkt signal transduction pathway. Requirement for Flk-1\u002FKDR activation. J. Biol. Chem. 273, 30366–30343 (1998).",{"doi":1031},"10.1074\u002Fjbc.273.46.30366",{"id":26,"text":1033,"url":26,"identifiers":1034},"Benjamin, L.E., Golijanin, D., Itin, A., Pode, D. & Keshet, E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103, 159–165 (1999).",{"doi":1035},"10.1172\u002FJCI5028",{"id":26,"text":1037,"url":26,"identifiers":1038},"Yuan, F. et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor\u002Fvascular permeability factor antibody. Proc. Natl. Acad. Sci. USA 93, 14765–14770 (1996).",{"doi":1039},"10.1073\u002Fpnas.93.25.14765",{"id":26,"text":1041,"url":26,"identifiers":1042},"Gerber, H.P. et al. VEGF is required for growth and survival in neonatal mice. Development 126, 1149–1159 (1999).",{"doi":1043},"10.1242\u002Fdev.126.6.1149",{"id":26,"text":1045,"url":26,"identifiers":1046},"Clauss, M. et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 172, 1535–1545 (1990).",{"doi":1047},"10.1084\u002Fjem.172.6.1535",{"id":26,"text":1049,"url":26,"identifiers":1050},"Broxmeyer, H.E. et al. Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor. Int. J. Hematol. 62, 203–215 (1995).",{"doi":1051},"10.1016\u002F0925-5710(95)00412-2",{"id":26,"text":1053,"url":26,"identifiers":1054},"Gabrilovich, D.I. et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2, 1096–1103 (1996).",{"doi":1055},"10.1038\u002Fnm1096-1096",{"id":26,"text":1057,"url":26,"identifiers":1058},"Hattori, K. et al. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J. Exp Med. 193, 1005–1014 (2001).",{"doi":1059},"10.1084\u002Fjem.193.9.1005",{"id":26,"text":1061,"url":26,"identifiers":1062},"Gerber, H.-P. et al. Vascular endothelial growth factor regulates hematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417, 954–958 (2002).",{"doi":1063},"10.1038\u002Fnature00821",{"id":26,"text":1065,"url":26,"identifiers":1066},"Senger, D.R. et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983–985 (1983).",{"doi":1067},"10.1126\u002Fscience.6823562",{"id":26,"text":1069,"url":26,"identifiers":1070},"Dvorak, H.F., Brown, L.F., Detmar, M. & Dvorak, A.M. Vascular permeability factor\u002Fvascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029–1039 (1995).",{},{"id":26,"text":1072,"url":26,"identifiers":1073},"Bates, D.O. & Curry, F.E. Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway. Am. J. Physiol. 273, H687–H694 (1997).",{"doi":1074},"10.1152\u002Fajpcell.1997.273.2.C687",{"id":26,"text":1076,"url":26,"identifiers":1077},"Roberts, W.G. & Palade, G.E. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci. 108, 2369–2379 (1995).",{"doi":1078},"10.1242\u002Fjcs.108.6.2369",{"id":26,"text":1080,"url":26,"identifiers":1081},"Ku, D.D., Zaleski, J.K., Liu, S. & Brock, T.A. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am. J. Physiol. 265, H586–H592 (1993).",{},{"id":26,"text":1083,"url":26,"identifiers":1084},"Yang, R. et al. Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J. Cardiovasc. Pharmacol. 27, 838–844 (1996).",{"doi":1085},"10.1097\u002F00005344-199606000-00011",{"id":26,"text":1087,"url":26,"identifiers":1088},"Houck, K.A. et al. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. 5, 1806–1814 (1991).",{"doi":1089},"10.1210\u002Fmend-5-12-1806",{"id":26,"text":1091,"url":26,"identifiers":1092},"Tischer, E. et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266, 11947–11954 (1991).",{"doi":1093},"10.1016\u002FS0021-9258(18)99049-6",{"id":26,"text":1095,"url":26,"identifiers":1096},"Ferrara, N. & Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161, 851–858 (1989).",{"doi":1097},"10.1016\u002F0006-291X(89)92678-8",{"id":26,"text":1099,"url":26,"identifiers":1100},"Houck, K.A., Leung, D.W., Rowland, A.M., Winer, J. & Ferrara, N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 267, 26031–26037 (1992).",{"doi":1101},"10.1016\u002FS0021-9258(18)35712-0",{"id":26,"text":1103,"url":26,"identifiers":1104},"Park, J.E., Keller, H.-A. & Ferrara, N. The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4, 1317–1326 (1993).",{"doi":1105},"10.1091\u002Fmbc.4.12.1317",{"id":26,"text":1107,"url":26,"identifiers":1108},"Keyt, B.A. et al. The carboxyl-terminal domain (111–165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271, 7788–7795 (1996).",{"doi":1109},"10.1074\u002Fjbc.271.13.7788",{"id":26,"text":1111,"url":26,"identifiers":1112},"Carmeliet, P. et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelila growth factor isoforms VEGF164 and VEGF188 . Nat. Med. 5, 495–502 (1999).",{"doi":1113},"10.1038\u002F8379",{"id":26,"text":1115,"url":26,"identifiers":1116},"Ruhrberg, C. et al. Spatially restricted patterning cues provided by heparin-binding VEGFA control blood vessel branching morphogenesis. Genes Dev. 16, 2684–2698 (2002).",{"doi":1117},"10.1101\u002Fgad.242002",{"id":26,"text":1119,"url":26,"identifiers":1120},"Dor, Y., Porat, R. & Keshet, E. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am. J. Physiol. 280, C1367–C1374 (2001).",{"doi":1121},"10.1152\u002Fajpcell.2001.280.6.C1367",{"id":26,"text":1123,"url":26,"identifiers":1124},"Semenza, G. Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 64, 993–998 (2002).",{"doi":1125},"10.1016\u002FS0006-2952(02)01168-1",{"id":26,"text":1127,"url":26,"identifiers":1128},"Mole, D.R., Maxwell, P.H., Pugh, C.W. & Ratcliffe, P.J. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. IUBMB Life 52, 43–47 (2001).",{"doi":1129},"10.1080\u002F15216540252774757",{"id":26,"text":1131,"url":26,"identifiers":1132},"Siemeister, G. et al. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56, 2299–2301 (1996).",{},{"id":26,"text":1134,"url":26,"identifiers":1135},"Iliopoulos, O., Levy, A.P., Jiang, C., Kaelin, W.G. & Goldberg, M.A. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. USA 93, 10595–10599 (1996).",{"doi":1136},"10.1073\u002Fpnas.93.20.10595",{"id":26,"text":1138,"url":26,"identifiers":1139},"Maxwell, P.H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271–275 (1999).",{"doi":1140},"10.1038\u002F20459",{"id":26,"text":1142,"url":26,"identifiers":1143},"Maxwell, P.H. & Ratcliffe, P.J. Oxygen sensors and angiogenesis. Semin. Cell Dev. Biol. 13, 29–37 (2002).",{"doi":1144},"10.1006\u002Fscdb.2001.0287",{"id":26,"text":1146,"url":26,"identifiers":1147},"Safran, M. & Kaelin, W.J. HIF hydroxylation and the mammalian oxygen-sensing pathway. J. Clin Invest. 111, 779–783 (2003).",{"doi":1148},"10.1172\u002FJCI200318181",{"id":26,"text":1150,"url":26,"identifiers":1151},"Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B. & Marme, D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem. 270, 25915–25919 (1995).",{"doi":1152},"10.1074\u002Fjbc.270.43.25915",{"id":26,"text":1154,"url":26,"identifiers":1155},"Okada, F. et al. Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor\u002Fvascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc. Natl. Acad. Sci. USA 95, 3609–3614 (1998).",{"doi":1156},"10.1073\u002Fpnas.95.7.3609",{"id":26,"text":1158,"url":26,"identifiers":1159},"Shibuya, M. et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family. Oncogene 8, 519–527 (1990).",{},{"id":26,"text":1161,"url":26,"identifiers":1162},"Terman, B.I. et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6, 1677–1683 (1991).",{},{"id":26,"text":1164,"url":26,"identifiers":1165},"de Vries, C. et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255, 989–991 (1992).",{"doi":1166},"10.1126\u002Fscience.1312256",{"id":26,"text":1168,"url":26,"identifiers":1169},"Gerber, H.P., Condorelli, F., Park, J. & Ferrara, N. Differential transcriptional regulation of the two VEGF receptor genes. Flt-1, but not Flk-1\u002FKDR, is up-regulated by hypoxia. J. Biol. Chem. 272, 23659–23667 (1997).",{"doi":1170},"10.1074\u002Fjbc.272.38.23659",{"id":26,"text":1172,"url":26,"identifiers":1173},"Park, J.E., Chen, H.H., Winer, J., Houck, K.A. & Ferrara, N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1\u002FKDR. J. Biol. Chem. 269, 25646–25654 (1994).",{"doi":1174},"10.1016\u002FS0021-9258(18)47298-5",{"id":26,"text":1176,"url":26,"identifiers":1177},"Olofsson, B. et al. Vascular endothelial growth factor B (VEGFB) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc. Natl. Acad. Sci. USA 95, 11709–11714 (1998).",{"doi":1178},"10.1073\u002Fpnas.95.20.11709",{"id":26,"text":1180,"url":26,"identifiers":1181},"Kendall, R.L. & Thomas, K.A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. USA 90, 10705–10709 (1993).",{"doi":1182},"10.1073\u002Fpnas.90.22.10705",{"id":26,"text":1184,"url":26,"identifiers":1185},"Davis-Smyth, T., Chen, H., Park, J., Presta, L.G. & Ferrara, N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15, 4919–4927 (1996).",{"doi":1186},"10.1002\u002Fj.1460-2075.1996.tb00872.x",{"id":26,"text":1188,"url":26,"identifiers":1189},"Waltenberger, J., Claesson Welsh, L., Siegbahn, A., Shibuya, M. & Heldin, C.H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269, 26988–26995 (1994).",{"doi":1190},"10.1016\u002FS0021-9258(18)47116-5",{"id":26,"text":1192,"url":26,"identifiers":1193},"Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7, 575–583 (2001).",{"doi":1194},"10.1038\u002F87904",{"id":26,"text":1196,"url":26,"identifiers":1197},"Gille, H. et al. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits VEGF-dependent PI 3 kinase activation and endothelial cell migration. EMBO J. 19, 4064–4073 (2000).",{"doi":1198},"10.1093\u002Femboj\u002F19.15.4064",{"id":26,"text":1200,"url":26,"identifiers":1201},"Maru, Y., Yamaguchi, S. & Shibuya, M. Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials. Oncogene 16, 2585–2595 (1998).",{"doi":1202},"10.1038\u002Fsj.onc.1201786",{"id":26,"text":1204,"url":26,"identifiers":1205},"Fong, G.H., Rossant, J., Gertsenstein, M. & Breitman, M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66–70 (1995).",{"doi":1206},"10.1038\u002F376066a0",{"id":26,"text":1208,"url":26,"identifiers":1209},"Fong, G.H., Zhang, L., Bryce, D.M. & Peng, J. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development 126, 3015–3025 (1999).",{"doi":1210},"10.1242\u002Fdev.126.13.3015",{"id":26,"text":1212,"url":26,"identifiers":1213},"Hiratsuka, S., Minowa, O., Kuno, J., Noda, T. & Shibuya, M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 4, 9349–9354 (1998).",{"doi":1214},"10.1073\u002Fpnas.95.16.9349",{"id":26,"text":1216,"url":26,"identifiers":1217},"Barleon, B. et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87, 3336–3343 (1996).",{"doi":1218},"10.1182\u002Fblood.V87.8.3336.bloodjournal8783336",{"id":26,"text":1220,"url":26,"identifiers":1221},"Hiratsuka, S. et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2, 289–300 (2002).",{"doi":1222},"10.1016\u002FS1535-6108(02)00153-8",{"id":26,"text":1224,"url":26,"identifiers":1225},"Hattori, K. et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat. Med. 8, 841–849 (2002).",{"doi":1226},"10.1038\u002Fnm740",{"id":26,"text":1228,"url":26,"identifiers":1229},"Luttun, A. et al. Revascularization of ischemic tissues by PLGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8, 831–840 (2002).",{"doi":1230},"10.1038\u002Fnm731",{"id":26,"text":1232,"url":26,"identifiers":1233},"LeCouter, J. et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299, 890–893 (2003).",{"doi":1234},"10.1126\u002Fscience.1079562",{"id":26,"text":1236,"url":26,"identifiers":1237},"Terman, B.I. et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187, 1579–1586 (1992).",{"doi":1238},"10.1016\u002F0006-291X(92)90483-2",{"id":26,"text":1240,"url":26,"identifiers":1241},"Shalaby, F. et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376, 62–66 (1995).",{"doi":1242},"10.1038\u002F376062a0",{"id":26,"text":1244,"url":26,"identifiers":1245},"Guo, D., Jia, Q., Song, H.Y., Warren, R.S. & Donner, D.B. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J. Biol. Chem. 270, 6729–6733 (1995).",{"doi":1246},"10.1074\u002Fjbc.270.12.6729",{"id":26,"text":1248,"url":26,"identifiers":1249},"Eliceiri, B.P. et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell 4, 915–924 (1999).",{"doi":1250},"10.1016\u002FS1097-2765(00)80221-X",{"id":26,"text":1252,"url":26,"identifiers":1253},"Takahashi, T., Ueno, H. & Shibuya, M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18, 2221–2230 (1999).",{"doi":1254},"10.1038\u002Fsj.onc.1202527",{"id":26,"text":1256,"url":26,"identifiers":1257},"Gille, H. et al. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific VEGF mutants. J. Biol. Chem. 276, 3222–3230 (2001).",{"doi":1258},"10.1074\u002Fjbc.M002016200",{"id":26,"text":1260,"url":26,"identifiers":1261},"Adini, A., Kornaga, T., Firoozbakht, F. & Benjamin, L.E. Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res. 62, 2749–2752 (2002).",{},{"id":26,"text":1263,"url":26,"identifiers":1264},"Soker, S., Fidder, H., Neufeld, G. & Klagsbrun, M. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J. Biol. Chem. 271, 5761–5767 (1996).",{"doi":1265},"10.1074\u002Fjbc.271.10.5761",{"id":26,"text":1267,"url":26,"identifiers":1268},"Soker, S., Takashima, S., Miao, H.Q., Neufeld, G. & Klagsbrun, M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92, 735–745 (1998).",{"doi":1269},"10.1016\u002FS0092-8674(00)81402-6",{"id":26,"text":1271,"url":26,"identifiers":1272},"Neufeld, G. et al. The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc. Med. 12, 13–19 (2002).",{"doi":1273},"10.1016\u002FS1050-1738(01)00140-2",{"id":26,"text":1275,"url":26,"identifiers":1276},"Kawasaki, T. et al. A requirement for neuropilin-1 in embryonic vessel formation, Development 126, 4895–4902 (1999).",{"doi":1277},"10.1242\u002Fdev.126.21.4895",{"id":26,"text":1279,"url":26,"identifiers":1280},"Lee, P. et al. Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc. Natl. Acad. Sci. USA 99, 10470–10475 (2002).",{"doi":1281},"10.1073\u002Fpnas.162366299",{"id":26,"text":1283,"url":26,"identifiers":1284},"Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435–439 (1996).",{"doi":1285},"10.1038\u002F380435a0",{"id":26,"text":1287,"url":26,"identifiers":1288},"Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439–442 (1996).",{"doi":1289},"10.1038\u002F380439a0",{"id":26,"text":1291,"url":26,"identifiers":1292},"Bellomo, D. et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ. Res. 86, E29–E35 (2000).",{"doi":1293},"10.1161\u002F01.RES.86.2.e29",{"id":26,"text":1295,"url":26,"identifiers":1296},"Kitamoto, Y., Tokunaga, H. & Tomita, K. Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis. J. Clin. Invest. 99, 2351–2357 (1997).",{"doi":1297},"10.1172\u002FJCI119416",{"id":26,"text":1299,"url":26,"identifiers":1300},"Eremina, V. et al. Glomerular-specific alterations of VEGFA expression lead to distinct congenital and acquired renal diseases. J. Clin. Invest. 111, 707–716 (2003).",{"doi":1301},"10.1172\u002FJCI17423",{"id":26,"text":1303,"url":26,"identifiers":1304},"Ryan, A.M. et al. Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody. Toxicol. Pathol. 27, 78–86 (1999).",{"doi":1305},"10.1177\u002F019262339902700115",{"id":26,"text":1307,"url":26,"identifiers":1308},"Poole, A.R. The growth plate: cellular physiology, cartilage assembly and mineralization. in Cartilage: Molecular Aspects (eds. Hall, B.K. & Newman, S.A.) 179–211 (CRC Press, Boca Raton, Florida, 1991).",{},{"id":26,"text":1310,"url":26,"identifiers":1311},"Gerber, H.P. et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5, 623–628 (1999).",{"doi":1312},"10.1038\u002F9467",{"id":26,"text":1314,"url":26,"identifiers":1315},"Haigh, J.J., Gerber, H.P., Ferrara, N. & Wagner, E.F. Conditional inactivation of VEGFA in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development 127, 1445–1453 (2000).",{"doi":1316},"10.1242\u002Fdev.127.7.1445",{"id":26,"text":1318,"url":26,"identifiers":1319},"Zelzer, E. et al. Skeletal defects in VEGF(120\u002F120) mice reveal multiple roles for VEGF in skeletogenesis. Development 129, 1893–1904 (2002).",{"doi":1320},"10.1242\u002Fdev.129.8.1893",{"id":26,"text":1322,"url":26,"identifiers":1323},"Goede, V., Schmidt, T., Kimmina, S., Kozian, D. & Augustin, H.G. Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Lab. Invest. 78, 1385–1394 (1998).",{},{"id":26,"text":1325,"url":26,"identifiers":1326},"Phillips, H.S., Hains, J., Leung, D.W. & Ferrara, N. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology 127, 965–967 (1990).",{"doi":1327},"10.1210\u002Fendo-127-2-965",{"id":26,"text":1329,"url":26,"identifiers":1330},"Ferrara, N. et al. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat. Med. 4, 336–340 (1998).",{"doi":1331},"10.1038\u002Fnm0398-336",{"id":26,"text":1333,"url":26,"identifiers":1334},"Fraser, H.M. et al. Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology 141, 995–1000 (2000).",{"doi":1335},"10.1210\u002Fendo.141.3.7369",{"id":26,"text":1337,"url":26,"identifiers":1338},"Zimmermann, R.C. et al. Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey. J. Clin. Endocrinol. Metab. 86, 768–772 (2001).",{},{"id":26,"text":1340,"url":26,"identifiers":1341},"LeCouter, J. et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature 412, 877–884 (2001).",{"doi":1342},"10.1038\u002F35091000",{"id":26,"text":1344,"url":26,"identifiers":1345},"LeCouter, J., Lin, R. & Ferrara, N. Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis. Nat. Med. 8, 913–917 (2002).",{"doi":1346},"10.1038\u002Fnm0902-913",{"id":26,"text":1348,"url":26,"identifiers":1349},"Ferrara, N. et al. Differential expression of the angiogenic factor genes VEGF and EG-VEGF in normal and polycystic human ovaries. Am. J. Path. 162, 1881–1893 (2003).",{"doi":1350},"10.1016\u002FS0002-9440(10)64322-2",{"id":26,"text":1352,"url":26,"identifiers":1353},"Kim, K.J. et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362, 841–844 (1993).",{"doi":1354},"10.1038\u002F362841a0",{"id":26,"text":1356,"url":26,"identifiers":1357},"Fukumura, D. et al. Tumor induction of VEGF promoter activity in stromal cells. Cell 94, 715–725 (1998).",{"doi":1358},"10.1016\u002FS0092-8674(00)81731-6",{"id":26,"text":1360,"url":26,"identifiers":1361},"Gerber, H.P., Kowalski, J., Sherman, D., Eberhard, D.A. & Ferrara, N. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res. 60, 6253–6258 (2000).",{},{"id":26,"text":1363,"url":26,"identifiers":1364},"Tsuzuki, Y. et al. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α—&gt; hypoxia response element—&gt; VEGF cascade differ entially regulates vascular response and growth rate in tumors, Cancer Res. 60, 6248–6252 (2000).",{},{"id":26,"text":1366,"url":26,"identifiers":1367},"Inoue, M., Hager, J.H., Ferrara, N., Gerber, H.P. & Hanahan, D. VEGFA has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis. Cancer Cell. 1, 193–202 (2002).",{"doi":1368},"10.1016\u002FS1535-6108(02)00031-4",{"id":26,"text":1370,"url":26,"identifiers":1371},"Bergers, G. et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2, 737–744 (2000).",{"doi":1372},"10.1038\u002F35036374",{"id":26,"text":1374,"url":26,"identifiers":1375},"Klement, G. et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105, R15–R24 (2000).",{"doi":1376},"10.1172\u002FJCI8829",{"id":26,"text":1378,"url":26,"identifiers":1379},"Lee, C.G. et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 60, 5565–5570 (2000).",{},{"id":26,"text":1381,"url":26,"identifiers":1382},"Presta, L.G. et al. Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57, 4593–4599 (1997).",{},{"id":26,"text":1384,"url":26,"identifiers":1385},"Prewett, M. et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis. Cancer Res. 59, 5209–5218 (1999).",{},{"id":26,"text":1387,"url":26,"identifiers":1388},"Wood, J.M. et al. PTK787\u002FZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60, 2178–2189 (2000).",{},{"id":26,"text":1390,"url":26,"identifiers":1391},"Holash, J. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc. Natl. Acad. Sci. USA 99, 11393–11398 (2002).",{"doi":1392},"10.1073\u002Fpnas.172398299",{"id":26,"text":1394,"url":26,"identifiers":1395},"Kabbinavar, F. et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)\u002Fleucovorin (LV) with FU\u002FLV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 21, 60–65 (2003).",{"doi":1396},"10.1200\u002FJCO.2003.10.066",{"id":26,"text":1398,"url":26,"identifiers":1399},"Yang, J.C. et al. A randomized trial of bevacizumab (anti-VEGF antibody) in metastatic renal cancer. N. Engl. J. Med. (in the press).",{},{"id":26,"text":1401,"url":26,"identifiers":1402},"Gerber, H.P. & Ferrara, N. The role of VEGF in normal and neoplastic hematopoiesis. J. Mol. Med. 81, 20–31 (2003).",{"doi":1403},"10.1007\u002Fs00109-002-0397-4",{"id":26,"text":1405,"url":26,"identifiers":1406},"Smolich, B.D. et al. The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemi blasts. Blood 97, 1413–1421 (2001).",{"doi":1407},"10.1182\u002Fblood.V97.5.1413",{"id":26,"text":1409,"url":26,"identifiers":1410},"Dias, S. et al. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J. Clin. Invest. 106, 511–521 (2000).",{"doi":1411},"10.1172\u002FJCI8978",{"id":26,"text":1413,"url":26,"identifiers":1414},"Garner, A. Vascular diseases. in Pathobiology of Ocular Disease 2nd edn. (eds. Garner, A. & Klintworth, G.K.) 1625–1710 (Marcel Dekker, New York, 1994).",{},{"id":26,"text":1416,"url":26,"identifiers":1417},"Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480–1487 (1994).",{"doi":1418},"10.1056\u002FNEJM199412013312203",{"id":26,"text":1420,"url":26,"identifiers":1421},"Malecaze, F. et al. Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch. Ophthalmol. 112, 1476–1482 (1994).",{"doi":1422},"10.1001\u002Farchopht.1994.01090230090028",{"id":26,"text":1424,"url":26,"identifiers":1425},"Aiello, L.P. et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA 92, 10457–10461 (1995).",{"doi":1426},"10.1073\u002Fpnas.92.23.10457",{"id":26,"text":1428,"url":26,"identifiers":1429},"Adamis, A.P. et al. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch. Ophthalmol. 114, 66–71 (1996).",{"doi":1430},"10.1001\u002Farchopht.1996.01100130062010",{"id":26,"text":1432,"url":26,"identifiers":1433},"Lopez, P.F., Sippy, B.D., Lambert, H.M., Thach, A.B. & Hinton, D.R. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest. Ophthalmol. Vis. Sci. 37, 855–868 (1996).",{},{"id":26,"text":1435,"url":26,"identifiers":1436},"Chen, Y. et al. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J. Mol. Biol. 293, 865–881 (1999).",{"doi":1437},"10.1006\u002Fjmbi.1999.3192",{"id":26,"text":1439,"url":26,"identifiers":1440},"Ruckman, J. et al. 2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. J. Biol. Chem. 273, 20556–20567 (1998).",{"doi":1441},"10.1074\u002Fjbc.273.32.20556",{"id":26,"text":1443,"url":26,"identifiers":1444},"Krzystolik, M.G. et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120, 338–346 (2002).",{"doi":1445},"10.1001\u002Farchopht.120.3.338",{"id":26,"text":1447,"url":26,"identifiers":1448},"Detmar, M. et al. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J. Invest. Dermatol. 105, 44–50 (1995).",{"doi":1449},"10.1111\u002F1523-1747.ep12312542",{"id":26,"text":1451,"url":26,"identifiers":1452},"Detmar, M. et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J. Invest. Dermatol. 111, 1–6 (1998).",{"doi":1453},"10.1046\u002Fj.1523-1747.1998.00262.x",{"id":26,"text":1455,"url":26,"identifiers":1456},"Cramer, T. HIF1α is essential for myeloid cell-mediated inflammation. Cell 112, 645–657 (2003).",{"doi":1457},"10.1016\u002FS0092-8674(03)00154-5",{"id":26,"text":1459,"url":26,"identifiers":1460},"Kovacs, Z., Ikezaki, K., Samoto, K., Inamura, T. & Fukui, M. VEGF and flt. Expression time kinetics in rat brain infarct. Stroke 27, 1865–1872 (1996).",{"doi":1461},"10.1161\u002F01.STR.27.10.1865",{"id":26,"text":1463,"url":26,"identifiers":1464},"van Bruggen, N. et al. VEGF antagonism reduces edema formation and tissue damage after ischemia\u002Freperfusion injury in the mouse brain. J. Clin. Invest. 104, 1613–1620 (1999).",{"doi":1465},"10.1172\u002FJCI8218",{"id":26,"text":1467,"url":26,"identifiers":1468},"Paul, R. et al. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat. Med. 7, 222–227 (2001).",{"doi":1469},"10.1038\u002F84675",{"id":26,"text":1471,"url":26,"identifiers":1472},"Yen, S.S.C. Polycystic ovary syndrome (hyperandrogenic chronic anovulation). in Reproductive Endocrinology (eds. Yen, S.S.C., Jaffe, R.B. & Barbieri, R.L.) 436–478 (W.B. Saunders, Philadelphia, 1999).",{},{"id":26,"text":1474,"url":26,"identifiers":1475},"McLaren, J. et al. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. J. Clin. Invest. 98, 482–489 (1996).",{"doi":1476},"10.1172\u002FJCI118815",{"id":26,"text":1478,"url":26,"identifiers":1479},"Maynard, S.E. et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 111, 649–658 (2003).",{"doi":1480},"10.1172\u002FJCI17189",{"id":26,"text":1482,"url":26,"identifiers":1483},"Kerbel, R. & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727–739 (2002).",{"doi":1484},"10.1038\u002Fnrc905",{"id":26,"text":1486,"url":26,"identifiers":1487},"Henry, T.D. et al. The VIVA trial: Vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation 107, 1359–1365 (2003).",{"doi":1488},"10.1161\u002F01.CIR.0000061911.47710.8A",{"id":26,"text":1490,"url":26,"identifiers":1491},"Makinen, K. et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol. Ther. 6, 127–133 (2002).",{"doi":1492},"10.1006\u002Fmthe.2002.0638",{"id":26,"text":1494,"url":26,"identifiers":1495},"Dor, Y. et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J. 21, 1939–1947 (2002).",{"doi":1496},"10.1093\u002Femboj\u002F21.8.1939",{"id":26,"text":1498,"url":26,"identifiers":1499},"Street, J. et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc. Natl. Acad. Sci. USA 99, 9656–9661 (2002).",{"doi":1500},"10.1073\u002Fpnas.152324099",false,{"id":1503,"createTime":1504,"updateTime":1504,"relativeEntities":1505,"slug":1506,"properties":1507,"entityType":854,"verifyStatus":25,"verifyTime":1520,"verifyNote":855,"syncStatus":28,"languages":1521,"translateLanguages":26,"viewCount":36,"primaryUrl":1522,"fullTextUrl":26,"authors":1523,"publicationType":918,"publisherRelationship":1544,"citationCount":1581,"citationInfo":1582,"publishDate":1596,"publishYear":1597,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1598,"isForceReanalyzing":1501},"b9ff7f30-8300-4d83-a814-7bfa6cf832a7","2024-09-23T06:53:53.325+00:00",[],"Angiogenesis-in-cancer-vascular-rheumatoid-and-other-disease",{"mag":1508,"keywords":1510,"openalex":1511,"abstract":1513,"title":1514,"pm":1516,"doi":1518},{"VOID":1509},"2000000541",{},{"VOID":1512},"W2000000541",{},{"EN":1515},"Angiogenesis in cancer, vascular, rheumatoid and other disease",{"VOID":1517},"7584949",{"VOID":1519},"10.1038\u002Fnm0195-27","2024-09-23T06:53:53.324+00:00",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm0195-27",[1524],{"id":1525,"sortIndex":36,"researcher":26,"roles":1526,"affiliations":1527,"properties":1539},"00b18fd3-7926-4deb-b91a-bc4af5ae2cb7",[],[1528],{"id":1529,"sortIndex":36,"affiliation":1530,"properties":26},"2435e46c-183e-4807-8bd5-2afb022a21cb",{"id":1531,"createTime":1532,"updateTime":1533,"relativeEntities":1534,"slug":1535,"properties":1536,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a22b570f-9c64-436a-aaad-373827eb8809","2023-12-31T06:59:50.271+00:00","2024-09-23T06:53:53.350+00:00",[],"Children-s-Hospital-Boston-Massachusetts-USA",{"title":1537},{"VI":1538},"Children's Hospital, Boston, Massachusetts USA",{"openalex":1540,"title":1542},{"VOID":1541},"A5088978035",{"EN":1543},"Judah Folkman",{"url":26,"publisher":1545,"properties":1575},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1546,"slug":663,"properties":1547,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1553,"manageAffiliations":1554,"indexDatabases":1555,"url":755,"thumbnailPath":26,"statistic":1570,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":1548,"issn":1549,"introduce":1550,"eissn":1551,"title":1552},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[1556,1563],{"id":736,"indexDatabase":1557,"url":749,"indexYears":750,"academicFieldIds":1562,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":1558,"label":1559,"description":1560,"key":746,"publicationTags":1561,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":1564,"url":730,"indexYears":26,"academicFieldIds":1569,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":1565,"label":1566,"description":1567,"key":726,"publicationTags":1568,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":1571,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":1572,"totalCitation":772,"totalCitationByYear":1573,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":1574,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":1576,"pages":1578,"issue":1580},{"VOID":1577},"1",{"VOID":1579},"27-30",{"VOID":1577},7663,{"total":1581,"publishYear":26,"statisticByYear":1583},{"2012":1584,"2013":1585,"2014":149,"2015":1586,"2016":1587,"2017":1588,"2018":1589,"2019":1590,"2020":1591,"2021":1592,"2022":1593,"2023":1594,"2024":1595},321,308,223,194,192,137,150,117,142,105,82,55,"1995-01-01",1995,[1599,1603,1606,1610,1614,1618,1621,1625,1629,1633,1636,1640,1644,1648,1652,1656,1659,1663,1667,1671,1674,1678,1681,1685,1689,1693,1697,1700,1704,1708,1711,1714,1718,1722,1725,1728,1731,1734,1738,1742,1745,1749,1753,1756,1760,1764,1768,1771,1774,1777,1780,1784,1787,1791,1794,1797,1801,1805,1809,1813,1817,1821,1825,1829,1833,1836,1839,1843,1847,1851,1855,1858],{"id":26,"text":1600,"url":26,"identifiers":1601},"Demicheli, R. et al. Local recurrences following mastectomy: support for the concept of tumor dormancy.J, natn. Cancer Inst. 86, 45–48 (1994).",{"doi":1602},"10.1093\u002Fjnci\u002F86.1.45",{"id":26,"text":1604,"url":26,"identifiers":1605},"Morrow, M. & Jordan, V.C. Risk factors and the prevention of breast cancer with tamoxifen. Cancer Surveys 18, 211–229 (1993).",{},{"id":26,"text":1607,"url":26,"identifiers":1608},"Kripke, M.L. Immunoregulation of carcinogenesis: past, present, and future. J. natn. Cancer Inst. 80, 722–727 (1988).",{"doi":1609},"10.1093\u002Fjnci\u002F80.10.722",{"id":26,"text":1611,"url":26,"identifiers":1612},"Sugarbaker, E.V. Cancer metastasis: a product of tumor-host interactions. Curr. Prob. Cancer 3, 1–59 (1979).",{"doi":1613},"10.1016\u002FS0147-0272(79)80008-2",{"id":26,"text":1615,"url":26,"identifiers":1616},"Fider, I.J. & Ellis, L.M. Cell 79, 185–188 (1994).",{"doi":1617},"10.1016\u002F0092-8674(94)90187-2",{"id":26,"text":1619,"url":26,"identifiers":1620},"Prehn, R.T. The inhibition of tumor growth by tumor mass. Cancer Res. 51, 2–4 (1991).",{},{"id":26,"text":1622,"url":26,"identifiers":1623},"Folkman, J., Watson, K. Ingber & D. Hanahan, D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339, 58–61 (1989).",{"doi":1624},"10.1038\u002F339058a0",{"id":26,"text":1626,"url":26,"identifiers":1627},"Kandel, J. et al. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell 66, 1095–1104 (1991).",{"doi":1628},"10.1016\u002F0092-8674(91)90033-U",{"id":26,"text":1630,"url":26,"identifiers":1631},"Weidner, N., Semple, J., Welch, W. & Folkman, J. Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. N. Engl. J. Med. 324, 1–8 (1991).",{"doi":1632},"10.1056\u002FNEJM199101033240101",{"id":26,"text":1634,"url":26,"identifiers":1635},"Folkman, J. Tumor angiogenesis. In: Mendelsohn, J., Howley, P., Liotta, L., Israel, M., eds. The Molecular Basis of Cancer, W.B. Saunders Company, Philadelphia, in press (1994).",{},{"id":26,"text":1637,"url":26,"identifiers":1638},"Folkman, J. Angiogenesis and breast cancer. J. clin. Oncol 12, 441–443 (1994).",{"doi":1639},"10.1200\u002FJCO.1994.12.3.441",{"id":26,"text":1641,"url":26,"identifiers":1642},"Nicosia, R.F., Tchao, R. & Leighton, J. Interactions between newly formed en-dothelial channels and carcinoma cells in plasma clot culture. Clin. exp. Metastasis. 4, 91–104 (1986).",{"doi":1643},"10.1007\u002FBF00119076",{"id":26,"text":1645,"url":26,"identifiers":1646},"Rak, J.W., Hegmann, E.J., Lu, C. & Kerbel, R.S. Progressive loss of sensitivity to en-dothelium-derived growth inhibitors expressed by human melanoma cells during disease progression. J. cell. Physiol. 159, 245–255 (1994).",{"doi":1647},"10.1002\u002Fjcp.1041590208",{"id":26,"text":1649,"url":26,"identifiers":1650},"Hamada, J., Cavanaugh, P.G., Lotan, O. & Nicolson, G. Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothe-lial cells derived from target organs for metastasis. Br. J. Cancer 66, 349–354 (1992).",{"doi":1651},"10.1038\u002Fbjc.1992.269",{"id":26,"text":1653,"url":26,"identifiers":1654},"Rastinejad, F., Polveini, P.J. & Bouck, N.P. Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene. Cell 56, 345–355 (1989).",{"doi":1655},"10.1016\u002F0092-8674(89)90238-9",{"id":26,"text":1657,"url":26,"identifiers":1658},"Bouck, N.P. Tumor angiogenesis: the role of oncogenes and tumor suppressor gene. Cancer Cells. 2, 179–185 (1990).",{},{"id":26,"text":1660,"url":26,"identifiers":1661},"Dameron, K.M., Volpert, O.V., Tainsky, M.A. & Bouck, N.P. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265, 1582–1584 (1994).",{"doi":1662},"10.1126\u002Fscience.7521539",{"id":26,"text":1664,"url":26,"identifiers":1665},"Maciag, T., Mehlman, T., Friesel, R. & Schreiber, A. Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain. Science 225, 932–935 (1984).",{"doi":1666},"10.1126\u002Fscience.6382607",{"id":26,"text":1668,"url":26,"identifiers":1669},"Shing, Y. et al. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 223, 1296–1298 (1984).",{"doi":1670},"10.1126\u002Fscience.6199844",{"id":26,"text":1672,"url":26,"identifiers":1673},"Ferrara, N. & Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Com-mun. 161, 851–855 (1989).",{},{"id":26,"text":1675,"url":26,"identifiers":1676},"Fett, J.W. et al. Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells. Biochem. 24, 5480–5486 (1985).",{"doi":1677},"10.1021\u002Fbi00341a030",{"id":26,"text":1679,"url":26,"identifiers":1680},"Folkman, J., Shing, Y., J. biol Chem. 267, 10931–10934 (1992).",{"doi":976},{"id":26,"text":1682,"url":26,"identifiers":1683},"O'Reilly, S. et al. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315–328 (1994).",{"doi":1684},"10.1016\u002F0092-8674(94)90200-3",{"id":26,"text":1686,"url":26,"identifiers":1687},"Van Meir, E.G. et al. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature Genetics 8, 171–176 (1994).",{"doi":1688},"10.1038\u002Fng1094-171",{"id":26,"text":1690,"url":26,"identifiers":1691},"Poste, G. & Fidler, I.J. The pathogenesis of cancer metastasis. Nature 283, 139–146 (1980).",{"doi":1692},"10.1038\u002F283139a0",{"id":26,"text":1694,"url":26,"identifiers":1695},"Zetter, B. The cellular basis of site-specific tumor metastasis. N. Engl. J. Med. 322, 605–612 (1990).",{"doi":1696},"10.1056\u002FNEJM199003013220907",{"id":26,"text":1698,"url":26,"identifiers":1699},"Holmgren, L., O'Reilly, M. & Folkman, J. in press (1994).",{},{"id":26,"text":1701,"url":26,"identifiers":1702},"Takeshita, S. et al. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J. clin. Invest 93, 662–670 (1994).",{"doi":1703},"10.1172\u002FJCI117018",{"id":26,"text":1705,"url":26,"identifiers":1706},"Shweiki, D., Itin, A., Soffer, D. & Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843–845 (1992).",{"doi":1707},"10.1038\u002F359843a0",{"id":26,"text":1709,"url":26,"identifiers":1710},"Ferrara, N. personal communication (1994).",{},{"id":26,"text":1712,"url":26,"identifiers":1713},"Yuhas, J.M. & Pazmino, N.H. Inhibition of subcutaneously growing line 1 carcinomas due to metastatic spread. Cancer Res. 34, 2005–2010 (1974).",{},{"id":26,"text":1715,"url":26,"identifiers":1716},"Nanus, D. et al. Expression of basic fibroblast growth factor in primary human renal tumors: correlation with poor survival. J. natn. Cancer Inst. 85, 1597–1599 (1993).",{"doi":1717},"10.1093\u002Fjnci\u002F85.19.1597",{"id":26,"text":1719,"url":26,"identifiers":1720},"Nguyen, M. et al. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J. natn. Cancer Inst. 86, 356–361 (1994).",{"doi":1721},"10.1093\u002Fjnci\u002F86.5.356",{"id":26,"text":1723,"url":26,"identifiers":1724},"Kohn, E. et al. Phase I trial of signal transduction inhibitor, CAI. Proc. Amer. Assoc. Cancer Res. 35,244(1994).",{},{"id":26,"text":1726,"url":26,"identifiers":1727},"Liotta, L.A. personal communication (1994).",{},{"id":26,"text":1729,"url":26,"identifiers":1730},"Folkman, J. Clinical applications of angiogenesis research. New Engl. J. Med. in press (1994).",{},{"id":26,"text":1732,"url":26,"identifiers":1733},"Watanabe, H., Nguyen, M., Schizer, M., Li, V., Hayes, D.R., Sallan, S., Folkman, J. Basic fibroblast growth factor in human serum – a prognostic test for breast cancer. Molec. Biol. Cell 3, 324a (1992).",{},{"id":26,"text":1735,"url":26,"identifiers":1736},"Li, V.W. et al. Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumors. The Lancet 344, 82–86 (1994).",{"doi":1737},"10.1016\u002FS0140-6736(94)91280-7",{"id":26,"text":1739,"url":26,"identifiers":1740},"Weidner, N. et al. Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J. natn. Cancer Inst. 84, 1875–1887 (1992).",{"doi":1741},"10.1093\u002Fjnci\u002F84.24.1875",{"id":26,"text":1743,"url":26,"identifiers":1744},"Weidner, N., Carroll, P.R., Flax, J., Blumenfeld, W. & Folkman, J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Amer. J. Pathol. 143, 401–409 (1993).",{},{"id":26,"text":1746,"url":26,"identifiers":1747},"Teicher, B.A. et al. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int. J. Cancer. 57, 920–925 (1994).",{"doi":1748},"10.1002\u002Fijc.2910570624",{"id":26,"text":1750,"url":26,"identifiers":1751},"Schaper, W., Schaper, J. Collateral Circulation: Heart, Brain, Kidney, Limbs. Kluwer Academic Publishers, Boston, (1993).",{"doi":1752},"10.1007\u002F978-1-4615-3092-3",{"id":26,"text":1754,"url":26,"identifiers":1755},"Miller, J.W. et al. Vascular endothelial growth factorJVascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Amer. J. Pathol 145, 574–584 (1994).",{},{"id":26,"text":1757,"url":26,"identifiers":1758},"Adamis, A.P. et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Amer. J. Ophthal. 118, 445–450(1994).",{"doi":1759},"10.1016\u002FS0002-9394(14)75794-0",{"id":26,"text":1761,"url":26,"identifiers":1762},"Takahashi, K. et al. Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J. clin. Invest. 93, 2357–2364 (1994).",{"doi":1763},"10.1172\u002FJCI117241",{"id":26,"text":1765,"url":26,"identifiers":1766},"Peacock, D.J., Banquerigo, M.L. & Brahn, E. Angiogenesis inhibition suppresses collagen arthritis. J. exp. Med. 175, 1135–1138 (1992).",{"doi":1767},"10.1084\u002Fjem.175.4.1135",{"id":26,"text":1769,"url":26,"identifiers":1770},"Nickoloff, B.J., Mitra, R.S., Varani, J., Dixit, V.M. & Polerini, P.J. Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. Amer. J. Pathol 44, 820–828 (1994).",{},{"id":26,"text":1772,"url":26,"identifiers":1773},"Bacharach-Buhles, M., Panz, B., Elgammal, S., Auer, T. & Altmeyer, P. The elongation of psoriatic capillaries, the result of epidermal hyperplasia, not of angiogenesis. J. Invest. Dermatol. 103, 263 (1994).",{},{"id":26,"text":1775,"url":26,"identifiers":1776},"Szabo, S. Animal model: cysteamine-induced and chronic duodenal ulcer in the rat. Amer. J. Pathol 93, 273–276 (1974).",{},{"id":26,"text":1778,"url":26,"identifiers":1779},"Szabo, S. et al. Orally administered FGF mutein: Effect on healing of chronic duodenal ulcers in rats. Digestive Disease and Sciences 34, 1323 (1989).",{},{"id":26,"text":1781,"url":26,"identifiers":1782},"Folkman, J. et al. Duodenal ulcer: discovery of a new mechanism and development of angiogenic therapy which accelerates healing. Ann. Surg. 214, 414–427 (1991).",{"doi":1783},"10.1097\u002F00000658-199110000-00006",{"id":26,"text":1785,"url":26,"identifiers":1786},"Hull, M.A., Cullen, D.J.E. & Hawkey, C.J. Basic fibroblast growth factor in gastric ulceration: mucosal levels and therapeutic potential. Gastroenterology 106, A97 (1994).",{},{"id":26,"text":1788,"url":26,"identifiers":1789},"Dvorak, H., Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. EnglJ. Med. 315, 1650–1659 (1986).",{"doi":1790},"10.1056\u002FNEJM198612253152606",{"id":26,"text":1792,"url":26,"identifiers":1793},"Wolfe, M.M. et al. Safety and efficacy of an angiogenic peptide, basic fibroblast growth factor (bFGF) in the treatment of gastroduodenal ulcers: A preliminary report. Gastroenterology 106, A212 (1994).",{},{"id":26,"text":1795,"url":26,"identifiers":1796},"Folkman, J. Angiogenesis in female reproductive organs. In: Steroid Hormones and Uterine Bleeding. Alexander, N.J., d'Arcangues, C., eds. American Association for the Advancement of Science Press, Washington DC, 144–158 (1992).",{},{"id":26,"text":1798,"url":26,"identifiers":1799},"Ravindranath, N., Little-Ihrig, L., Philips, H.S., Ferrara, N. & Zeleznik, A. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology 131, 254–260 (1992).",{"doi":1800},"10.1210\u002Fendo.131.1.1612003",{"id":26,"text":1802,"url":26,"identifiers":1803},"Redmer, D.A., Kirsch, J.D. & Reynolds, L.P. Production of mitogenic factors by cell types of bovine large estrogen-active and estrogen-inactive follicles. J. Anim. Sci. 69, 237–245 (1991).",{"doi":1804},"10.2527\u002F1991.691237x",{"id":26,"text":1806,"url":26,"identifiers":1807},"Reynolds, L.P., Killilea, D.S. & Redmer, D.A. Angiogenesis in the female reproductive system. FASEB 6, 886–892 (1992).",{"doi":1808},"10.1096\u002Ffasebj.6.3.1371260",{"id":26,"text":1810,"url":26,"identifiers":1811},"Greenwald, G.S. Temporal and topographic changes in DNA synthesis after induced follicular atresia. Biol. Reprod. 40, 175–181 (1989).",{"doi":1812},"10.1095\u002Fbiolreprod41.1.175",{"id":26,"text":1814,"url":26,"identifiers":1815},"Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. natn. Cancer Inst. 82, 4–6 (1990).",{"doi":1816},"10.1093\u002Fjnci\u002F82.1.4",{"id":26,"text":1818,"url":26,"identifiers":1819},"D'Amato, R.J., Loughnan, M.S., Flynn, E. & Folkman, J. Thalidomide is an inhibitor of angiogenesis. Proc. natn Acad. Sci.USA 91, 4082–4085 (1994).",{"doi":1820},"10.1073\u002Fpnas.91.9.4082",{"id":26,"text":1822,"url":26,"identifiers":1823},"Risau, W. & Ekblom, P. Production of a heparin-binding angiogenesis factor by the embryonic kidney. J. cell Biol 103, 1101–1107 (1986).",{"doi":1824},"10.1083\u002Fjcb.103.3.1101",{"id":26,"text":1826,"url":26,"identifiers":1827},"Millauer, B. et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835–846(1993).",{"doi":1828},"10.1016\u002F0092-8674(93)90573-9",{"id":26,"text":1830,"url":26,"identifiers":1831},"Poole, T.J. & Coffin, J.D. Vasculogenesis and angiogenesis - two distant morpho-genetic mechanisms establish embryonic vascular pattern. J. exp. Zool 251, 224–231 (1989).",{"doi":1832},"10.1002\u002Fjez.1402510210",{"id":26,"text":1834,"url":26,"identifiers":1835},"Liotta, L., Kleinerman, J. & Saidel, F. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res. 34, 997–1004 (1974).",{},{"id":26,"text":1837,"url":26,"identifiers":1838},"Brem, H., Goto, F., Budson, A., Saunders, L. & Folkman, J. Minimal drug resistance after prolonged antiangiogenic therapy with AGM-1470. Surgical Forum XLV, 674–677 (1994).",{},{"id":26,"text":1840,"url":26,"identifiers":1841},"Plate, K.H., Breier, G., Welch, H.A. & Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359, 845–848, (1992).",{"doi":1842},"10.1038\u002F359845a0",{"id":26,"text":1844,"url":26,"identifiers":1845},"Kerbel, R.S. Inhibition of tumour angiogenesis as a strategy to circumvent acquired resistance to anticancer therapeutic agents. BioEssays 13(1), 31–36 (1991).",{"doi":1846},"10.1002\u002Fbies.950130106",{"id":26,"text":1848,"url":26,"identifiers":1849},"Crowley, N.J. & Siegler, H.F. Relationship between disease-free interval and survival in patients with recurrent melanoma. Arch. Surg. 127, 1303–1308 (1992).",{"doi":1850},"10.1001\u002Farchsurg.1992.01420110045011",{"id":26,"text":1852,"url":26,"identifiers":1853},"Ezekowitz, R.A.B., Mulliken, J.B., Folkman, J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. New Engl. J. Med. 326, 1456–1463 (1992) (and corrections New Engl J. Med. 33, 300 (1994)).",{"doi":1854},"10.1056\u002FNEJM199205283262203",{"id":26,"text":1856,"url":26,"identifiers":1857},"Folkman, J. et al. (unpublished data).",{},{"id":26,"text":1859,"url":26,"identifiers":1860},"O'Reilly, M.S. et al. (unpublished data).",{},{"id":1862,"createTime":1863,"updateTime":1863,"relativeEntities":1864,"slug":1865,"properties":1866,"entityType":854,"verifyStatus":25,"verifyTime":1879,"verifyNote":855,"syncStatus":28,"languages":1880,"translateLanguages":26,"viewCount":36,"primaryUrl":1881,"fullTextUrl":26,"authors":1882,"publicationType":918,"publisherRelationship":1921,"citationCount":1959,"citationInfo":1960,"publishDate":1972,"publishYear":1973,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1974,"isForceReanalyzing":1501},"ceefa883-8765-46c8-9706-a072c8a5cc0d","2024-09-05T23:32:53.258+00:00",[],"Human-acute-myeloid-leukemia-is-organized-as-a-hierarchy-that-originates-from-a-primitive-hematopoietic-cell",{"mag":1867,"keywords":1869,"openalex":1870,"abstract":1872,"title":1873,"pm":1875,"doi":1877},{"VOID":1868},"2009886857",{},{"VOID":1871},"W2009886857",{},{"EN":1874},"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell",{"VOID":1876},"9212098",{"VOID":1878},"10.1038\u002Fnm0797-730","2024-09-05T23:32:53.257+00:00",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm0797-730",[1883,1904],{"id":1884,"sortIndex":115,"researcher":26,"roles":1885,"affiliations":1886,"properties":1897},"7eb63def-00af-4d8d-8406-c05a6a73a3f7",[],[1887],{"id":1888,"sortIndex":36,"affiliation":1889,"properties":26},"237d81be-6ca0-47ab-8ff6-c2cffab3a8f2",{"id":1890,"createTime":1891,"updateTime":1891,"relativeEntities":1892,"slug":1893,"properties":1894,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"42e1b8da-b49a-439c-b161-c6b82784aeb6","2024-09-05T23:32:53.269+00:00",[],"Department-of-Genetics-Research-Institute-Hospital-for-Sick-Children-and-Department-of-Molecular-and-Medical-Genetics-University-of-Toronto-555-University-Avenue-Toronto-Ontario-M5G1X8-Canada",{"title":1895},{"EN":1896},"Department of Genetics, Research Institute, Hospital for Sick Children and Department of Molecular and Medical Genetics, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada",{"openalex":1898,"orcid":1900,"title":1902},{"VOID":1899},"A5090356933",{"VOID":1901},"https:\u002F\u002Forcid.org\u002F0000-0002-9527-8317",{"EN":1903},"John E. Dick",{"id":1905,"sortIndex":36,"researcher":26,"roles":1906,"affiliations":1907,"properties":1914},"5bc31be9-9fb0-468c-97e2-9b1fa684dd4e",[],[1908],{"id":1909,"sortIndex":36,"affiliation":1910,"properties":26},"913097f6-9ec0-4ade-88fc-befe352b84d5",{"id":1890,"createTime":1891,"updateTime":1891,"relativeEntities":1911,"slug":1893,"properties":1912,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":1913},{"EN":1896},{"openalex":1915,"orcid":1917,"title":1919},{"VOID":1916},"A5016016794",{"VOID":1918},"https:\u002F\u002Forcid.org\u002F0000-0002-4735-5226",{"EN":1920},"Dominique Bonnet",{"url":26,"publisher":1922,"properties":1952},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1923,"slug":663,"properties":1924,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1930,"manageAffiliations":1931,"indexDatabases":1932,"url":755,"thumbnailPath":26,"statistic":1947,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":1925,"issn":1926,"introduce":1927,"eissn":1928,"title":1929},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[1933,1940],{"id":736,"indexDatabase":1934,"url":749,"indexYears":750,"academicFieldIds":1939,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":1935,"label":1936,"description":1937,"key":746,"publicationTags":1938,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":1941,"url":730,"indexYears":26,"academicFieldIds":1946,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":1942,"label":1943,"description":1944,"key":726,"publicationTags":1945,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":1948,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":1949,"totalCitation":772,"totalCitationByYear":1950,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":1951,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":1953,"pages":1955,"issue":1957},{"VOID":1954},"3",{"VOID":1956},"730-737",{"VOID":1958},"7",6637,{"total":1959,"publishYear":26,"statisticByYear":1961},{"2012":202,"2013":1962,"2014":1963,"2015":1964,"2016":1965,"2017":1966,"2018":1967,"2019":1968,"2020":1969,"2021":1968,"2022":1970,"2023":120,"2024":1971},467,435,437,370,324,286,291,278,254,138,"1997-07-01",1997,[1975,1979,1983,1987,1991,1995,1999,2003,2006,2010,2014,2017,2021,2025,2028,2032,2035,2039,2043,2047,2051,2055,2059,2063,2067,2071,2075,2078,2081,2085,2089,2093,2096,2100,2103,2106,2110,2113,2116],{"id":26,"text":1976,"url":26,"identifiers":1977},"Fialkow, P. et al. Clonal development, stem-cell differentiation, and clinical remission in acute nonlymphocytic leukemia. N. Engl. J. Med. 317, 468–473 (1987).",{"doi":1978},"10.1056\u002FNEJM198708203170802",{"id":26,"text":1980,"url":26,"identifiers":1981},"McCulloch, E. Stem cells in normal and leukemic hemopoiesis (Henry StrattonLecture). Blood 62, 1–13 (1983).",{"doi":1982},"10.1182\u002Fblood.V62.1.1.1",{"id":26,"text":1984,"url":26,"identifiers":1985},"Griffin, J. & Löwenberg, B. Clonogenic cells in acute myeloblastic leukemia. Blood 68, 1185–1195 (1986).",{"doi":1986},"10.1182\u002Fblood.V68.6.1185.1185",{"id":26,"text":1988,"url":26,"identifiers":1989},"Cline, M.J. The molecular basis of leukemia. N. Engl. J. Med. 330, 328–336 (1994).",{"doi":1990},"10.1056\u002FNEJM199402033300507",{"id":26,"text":1992,"url":26,"identifiers":1993},"Berger, R. et al. Cytogenetic studies on 519 consecutive de novo acute nonlympho cytic leukemias. Cancer Genet. Cytogenet. 29, 9–21 (1987).",{"doi":1994},"10.1016\u002F0165-4608(87)90026-4",{"id":26,"text":1996,"url":26,"identifiers":1997},"Bennett, J. et al. Proposals for the classification of the acute leukemias. Br. J. Haematol. 33, 451–458 (1976).",{"doi":1998},"10.1111\u002Fj.1365-2141.1976.tb03563.x",{"id":26,"text":2000,"url":26,"identifiers":2001},"Fialkow, P.J. et al. Acute nonlymphocytic leukemia: Heterogeneity of stem cell origin. Blood 57, 1068–1073 (1981).",{"doi":2002},"10.1182\u002Fblood.V57.6.1068.bloodjournal5761068",{"id":26,"text":2004,"url":26,"identifiers":2005},"Bartram, C.R. et al. Acute myeloid leukemia: Analysis of ras gene mutations and clonality defined by polymorphic X-linked loci. Leukemia 3, 247–256 (1989).",{},{"id":26,"text":2007,"url":26,"identifiers":2008},"van Lorn, K., Hagemeijer, A., Smit, E.M. & Lowenberg, B. In situ hybridization on May-Grünwald Giemsa-stained bone marrow and blood smears of patients with hematologic disorders allows detection of cell-lineage-specific cytogenetic abnormalities. Blood 82, 884–888 (1993).",{"doi":2009},"10.1182\u002Fblood.V82.3.884.884",{"id":26,"text":2011,"url":26,"identifiers":2012},"Fearon, E., Burke, P., Schiffer, C., Zehnbauer, B. & Vogelstein, B. Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphoblastic leukemia. N. Engl. J. Med. 315, 15–24 (1986).",{"doi":2013},"10.1056\u002FNEJM198607033150103",{"id":26,"text":2015,"url":26,"identifiers":2016},"Feuring-Buske, M. et al. Trisomy 4 in ‘stem cell-like’ leukemic cells of a patient with AML. Leukemia 9, 1318–1320 (1995).",{},{"id":26,"text":2018,"url":26,"identifiers":2019},"Greaves, M.F. Stem cell origins of leukaemia and curability. Br. J. Cancer 67, 413–423 (1993).",{"doi":2020},"10.1038\u002Fbjc.1993.81",{"id":26,"text":2022,"url":26,"identifiers":2023},"Keinänen, M., Griffin, J., Bloomfield, C., Machnrcki, J. & de la Chapelle, A. Clonalchromosomal abnormalities showing multiple-cell-lineage involvement in acute myeloid leukemia. N. Engl.J. Med. 318, 1153–1158 (1988).",{"doi":2024},"10.1056\u002FNEJM198805053181803",{"id":26,"text":2026,"url":26,"identifiers":2027},"McCulloch, E.A. et al. Heterogeneity in acute myeloblastic leukemia. Leukemia 2, 38S–49S (1988).",{},{"id":26,"text":2029,"url":26,"identifiers":2030},"Haase, D. et al. Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+sub-populations. Blood 86, 2906–2912 (1995).",{"doi":2031},"10.1182\u002Fblood.V86.8.2906.2906",{"id":26,"text":2033,"url":26,"identifiers":2034},"Mehrotra, B. et al. Cytogenetically aberrant cells in the stem cell compartment (CD34+1in−) in acute myeloid leukemia. Blood 86, 1139–1147 (1995).",{},{"id":26,"text":2036,"url":26,"identifiers":2037},"Larochelle, A. et al. Identification of primitive hematopoietic cells capable of repopulating NOD\u002FSCID mouse bone marrow: Implications for gene therapy. Nature Med. 2, 1329–1337 (1996).",{"doi":2038},"10.1038\u002Fnm1296-1329",{"id":26,"text":2040,"url":26,"identifiers":2041},"Dick, J.E. Normal and leukemic stem cells assayed in SCID mice. Semin. Immunol. 8, 197–206 (1996).",{"doi":2042},"10.1006\u002Fsmim.1996.0025",{"id":26,"text":2044,"url":26,"identifiers":2045},"Bhatia, M., Wang, J., Kapp, U., Bonnet, D. & Dick, J. Purification of primitive human hematopoietic cells capable of repopulating NOD\u002FSCID mice. Proc. Natl.Acad. Sci.USA 94, 5320–5325 (1997).",{"doi":2046},"10.1073\u002Fpnas.94.10.5320",{"id":26,"text":2048,"url":26,"identifiers":2049},"Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645–648 (1994).",{"doi":2050},"10.1038\u002F367645a0",{"id":26,"text":2052,"url":26,"identifiers":2053},"Larochelle, A. et al. Engraftment of immune-deficient mice with primitivehematopoietic cells from beta-thalassemia and sickle cell anemia patients:Implications for evaluating human gene therapy protocols. Hum. Mol. Genet. 4, 163–172 (1995).",{"doi":2054},"10.1093\u002Fhmg\u002F4.2.163",{"id":26,"text":2056,"url":26,"identifiers":2057},"Wang, J., Doedens, M. & Dick, J. Primitive human hematopoietic cells are enrichedin cord blood compared to adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell (SRC) assay. Blood 89, 3919–3924 (1997).",{"doi":2058},"10.1182\u002Fblood.V89.11.3919",{"id":26,"text":2060,"url":26,"identifiers":2061},"Porter, E. & Berry, R. The efficient design of transplantable tumor assays. Br. J. Cancer 17, 583–595 (1964).",{"doi":2062},"10.1038\u002Fbjc.1963.78",{"id":26,"text":2064,"url":26,"identifiers":2065},"Taswell, C. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol. 126, 1614–1619 (1981).",{"doi":2066},"10.4049\u002Fjimmunol.126.4.1614",{"id":26,"text":2068,"url":26,"identifiers":2069},"Civin, C. et al. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1 a cells. J. Immunol. 133, 157–165 (1984).",{"doi":2070},"10.4049\u002Fjimmunol.133.1.157",{"id":26,"text":2072,"url":26,"identifiers":2073},"Terstappen, L.W.W.M., Huang, S., Safford, M., Lansdorp, P.M. & Loken, M.R. Sequential generations of hematopoietic colonies derived from single nonlineagecommitted CD34+CD38 progenitor cells. Blood 77, 1218–1227 (1991).",{"doi":2074},"10.1182\u002Fblood.V77.6.1218.1218",{"id":26,"text":2076,"url":26,"identifiers":2077},"Terstappen, L. et al. Flow cytometry characterization of acute myeloid leukemia: IV. Comparison to the differentiation pathway of normal hematopoietic cells. Leukemia 6, 993–1000 (1992).",{},{"id":26,"text":2079,"url":26,"identifiers":2080},"Cashman, J. et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Stood (in the press).",{},{"id":26,"text":2082,"url":26,"identifiers":2083},"Moore, M., Williams, N. & Metcalfe, D. In vitro colony formation by normal and leukemic human hematopoietic cells: Characterization of the colony-forming cells. J. Natl. Cancer Inst. 50, 603 (1974).",{"doi":2084},"10.1093\u002Fjnci\u002F50.3.603",{"id":26,"text":2086,"url":26,"identifiers":2087},"Sutherland, H., Blair, A. & Zapf, R.W. Characterization of a hierarchy in human acute myeloid leukemia progenitor cells. Blood 87, 4754–4761 (1996).",{"doi":2088},"10.1182\u002Fblood.V87.11.4754.bloodjournal87114754",{"id":26,"text":2090,"url":26,"identifiers":2091},"Craig, W., Kay, R., Cutler, R.B. & Lansdorp, P.M. Expression of Thy-1 on human hematopoietic progenitor cells. J. Exp. Med. 177, 1331–1342 (1993).",{"doi":2092},"10.1084\u002Fjem.177.5.1331",{"id":26,"text":2094,"url":26,"identifiers":2095},"Terpstra, W. et al. Long-term leukemia-initiating capacity of a CD34− subpopulation of acute myeloid leukemia. Stood 87, 2187–2194 (1996).",{},{"id":26,"text":2097,"url":26,"identifiers":2098},"Sawyers, C., Gishizky, M., Quan, S., Golde, D. & Witte, O. Propagation of human blastic myeloid leukemias in the SCID mouse. Blood 79, 2089–2098 (1992).",{"doi":2099},"10.1182\u002Fblood.V79.8.2089.2089",{"id":26,"text":2101,"url":26,"identifiers":2102},"Cesano, A. et al. The severe combined immunodeficient (SCID) mouse as a model for myeloid leukemias. Oncogene 7, 827–836 (1992).",{},{"id":26,"text":2104,"url":26,"identifiers":2105},"Turhan, A.G. et al. Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia. Stood 85, 2154–2161 (1995).",{},{"id":26,"text":2107,"url":26,"identifiers":2108},"Lapidot, T. et al. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 255, 1137–1141 (1992).",{"doi":2109},"10.1126\u002Fscience.1372131",{"id":26,"text":2111,"url":26,"identifiers":2112},"Vormoor, J. et al. Immature human cord blood progenitors engraft and proliferate to high levels in immune-deficient SCID mice. Stood 83, 2489–2497 (1994).",{},{"id":26,"text":2114,"url":26,"identifiers":2115},"Sirard, C. et al. Normal and leukemic SCID-repopulating cells (SRC) co-exist in the bone marrow and peripheral blood from CML patients in chronic phase while leukemic SRC are detected in blast crisis. Stood 87, 1539–1548 (1996).",{},{"id":26,"text":2117,"url":26,"identifiers":2118},"Waye, J.S. & Willard, H.F. Structure, organization and sequence of alpha satellite DNA from human chromosome 17: Evidence for evolution by unequal crossing-over and ancestral pentamer repeat shared with the human X chromosome. Mol. Cell. Biol. 6, 3156–3165 (1986).",{"doi":2119},"10.1128\u002FMCB.6.9.3156",{"id":2121,"createTime":2122,"updateTime":2122,"relativeEntities":2123,"slug":2124,"properties":2125,"entityType":854,"verifyStatus":25,"verifyTime":2122,"verifyNote":855,"syncStatus":28,"languages":2140,"translateLanguages":26,"viewCount":36,"primaryUrl":2141,"fullTextUrl":26,"authors":2142,"publicationType":918,"publisherRelationship":2186,"citationCount":2224,"citationInfo":2225,"publishDate":2237,"publishYear":2238,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2239,"isForceReanalyzing":1501},"56df5b8e-1575-4f60-b7a7-a601bea38962","2024-09-11T18:18:51.221+00:00",[],"Microenvironmental-regulation-of-tumor-progression-and-metastasis",{"mag":2126,"keywords":2128,"pmc":2129,"openalex":2131,"abstract":2133,"title":2134,"pm":2136,"doi":2138},{"VOID":2127},"2033278321",{},{"VOID":2130},"3954707",{"VOID":2132},"W2033278321",{},{"EN":2135},"Microenvironmental regulation of tumor progression and metastasis",{"VOID":2137},"24202395",{"VOID":2139},"10.1038\u002Fnm.3394",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm.3394",[2143,2165],{"id":2144,"sortIndex":115,"researcher":26,"roles":2145,"affiliations":2146,"properties":2158},"2dc2be3d-0d0e-4dc6-89d8-889fbeadb7eb",[],[2147],{"id":2148,"sortIndex":36,"affiliation":2149,"properties":26},"f839ebb9-3da3-4243-a951-22671edecb2b",{"id":2150,"createTime":2151,"updateTime":2152,"relativeEntities":2153,"slug":2154,"properties":2155,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"c429960b-0bb4-49ca-ba8a-585374403e1d","2024-09-04T20:11:40.890+00:00","2024-09-22T23:02:36.472+00:00",[],"Cancer-Biology-and-Genetics-Program-Memorial-Sloan-Kettering-Cancer-Center-New-York-USA-",{"title":2156},{"EN":2157},"Cancer Biology and Genetics Program, Memorial-Sloan Kettering Cancer Center, New York, USA.",{"openalex":2159,"orcid":2161,"title":2163},{"VOID":2160},"A5009785954",{"VOID":2162},"https:\u002F\u002Forcid.org\u002F0000-0002-6332-2598",{"EN":2164},"Johanna A. Joyce",{"id":2166,"sortIndex":36,"researcher":26,"roles":2167,"affiliations":2168,"properties":2179},"a5cd7f18-7da8-4ae8-af0c-be607f2ca680",[],[2169],{"id":2170,"sortIndex":36,"affiliation":2171,"properties":26},"76b0acbe-3dea-468a-afe0-e236f9804745",{"id":2172,"createTime":2173,"updateTime":2173,"relativeEntities":2174,"slug":2175,"properties":2176,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"7104a851-d2d1-4887-a020-8664835863c8","2024-09-11T18:18:51.228+00:00",[],"Cancer-Biology-and-Genetics-Program-Memorial-Sloan-Kettering-Cancer-Center-New-York-New-York-USA",{"title":2177},{"EN":2178},"Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA",{"openalex":2180,"orcid":2182,"title":2184},{"VOID":2181},"A5009869289",{"VOID":2183},"https:\u002F\u002Forcid.org\u002F0000-0002-6969-3250",{"EN":2185},"Daniela F. Quail",{"url":26,"publisher":2187,"properties":2217},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2188,"slug":663,"properties":2189,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2195,"manageAffiliations":2196,"indexDatabases":2197,"url":755,"thumbnailPath":26,"statistic":2212,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":2190,"issn":2191,"introduce":2192,"eissn":2193,"title":2194},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[2198,2205],{"id":736,"indexDatabase":2199,"url":749,"indexYears":750,"academicFieldIds":2204,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":2200,"label":2201,"description":2202,"key":746,"publicationTags":2203,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":2206,"url":730,"indexYears":26,"academicFieldIds":2211,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":2207,"label":2208,"description":2209,"key":726,"publicationTags":2210,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":2213,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":2214,"totalCitation":772,"totalCitationByYear":2215,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":2216,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":2218,"pages":2220,"issue":2222},{"VOID":2219},"19",{"VOID":2221},"1423-1437",{"VOID":2223},"11",6288,{"total":2224,"publishYear":26,"statisticByYear":2226},{"2013":59,"2014":258,"2015":2227,"2016":2228,"2017":2229,"2018":2230,"2019":2231,"2020":2232,"2021":2233,"2022":2234,"2023":2235,"2024":2236},271,362,469,526,618,743,906,932,818,522,"2013-11-01",2013,[2240,2244,2248,2252,2256,2260,2264,2268,2272,2276,2279,2283,2287,2291,2295,2299,2303,2307,2311,2315,2319,2323,2327,2331,2335,2339,2343,2347,2351,2355,2359,2363,2367,2371,2375,2379,2383,2387,2391,2395,2399,2403,2407,2411,2415,2419,2423,2427,2431,2435,2439,2443,2447,2451,2455,2459,2463,2467,2471,2475,2479,2483,2486,2490,2494,2498,2502,2506,2510,2514,2516,2520,2524,2528,2532,2536,2540,2544,2548,2552,2556,2560,2564,2568,2572,2576,2580,2584,2588,2592,2596,2600,2604,2608,2612,2616,2620,2624,2628,2632,2636,2640,2644,2648,2652,2656,2660,2664,2668,2672,2676,2680,2684,2688,2692,2696,2700,2704,2708,2712,2716,2720,2724,2728,2732,2736,2740,2744,2748,2752,2756,2760,2764,2768,2772,2776,2780,2784,2788,2792,2796,2800,2804,2808,2812,2816,2820,2823,2827,2831,2835,2839,2843,2847,2851,2855,2859,2863,2867,2871,2875,2879,2883,2887,2891,2895,2899,2903,2907,2911,2915,2919,2923,2927,2931,2935,2939,2943,2947,2951,2955,2959,2963,2967,2971,2975,2979,2983,2987,2991,2995,2999,3003,3007,3011,3015,3019,3023],{"id":26,"text":2241,"url":26,"identifiers":2242},"Joyce, J.A. & Pollard, J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9, 239–252 (2009).",{"doi":2243},"10.1038\u002Fnrc2618",{"id":26,"text":2245,"url":26,"identifiers":2246},"Balkwill, F. & Mantovani, A. Inflammation and cancer: back to Virchow? Lancet 357, 539–545 (2001).",{"doi":2247},"10.1016\u002FS0140-6736(00)04046-0",{"id":26,"text":2249,"url":26,"identifiers":2250},"Hanahan, D. & Coussens, L.M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21, 309–322 (2012).",{"doi":2251},"10.1016\u002Fj.ccr.2012.02.022",{"id":26,"text":2253,"url":26,"identifiers":2254},"Hanahan, D. & Weinberg, R.A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011).",{"doi":2255},"10.1016\u002Fj.cell.2011.02.013",{"id":26,"text":2257,"url":26,"identifiers":2258},"Weis, S.M. & Cheresh, D.A. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med. 17, 1359–1370 (2011).",{"doi":2259},"10.1038\u002Fnm.2537",{"id":26,"text":2261,"url":26,"identifiers":2262},"Lindau, D., Gielen, P., Kroesen, M., Wesseling, P. & Adema, G.J. The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology 138, 105–115 (2013).",{"doi":2263},"10.1111\u002Fimm.12036",{"id":26,"text":2265,"url":26,"identifiers":2266},"Shiao, S.L., Ganesan, A.P., Rugo, H.S. & Coussens, L.M. Immune microenvironments in solid tumors: new targets for therapy. Genes Dev. 25, 2559–2572 (2011).",{"doi":2267},"10.1101\u002Fgad.169029.111",{"id":26,"text":2269,"url":26,"identifiers":2270},"Mantovani, A., Cassatella, M.A., Costantini, C. & Jaillon, S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat. Rev. Immunol. 11, 519–531 (2011).",{"doi":2271},"10.1038\u002Fnri3024",{"id":26,"text":2273,"url":26,"identifiers":2274},"Khazaie, K. et al. The significant role of mast cells in cancer. Cancer Metastasis Rev. 30, 45–60 (2011).",{"doi":2275},"10.1007\u002Fs10555-011-9286-z",{"id":26,"text":2277,"url":26,"identifiers":2278},"De Palma, M. & Naldini, L. Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy? Biochim. Biophys. Acta 1796, 5–10 (2009).",{},{"id":26,"text":2280,"url":26,"identifiers":2281},"Palucka, K. & Banchereau, J. Cancer immunotherapy via dendritic cells. Nat. Rev. Cancer 12, 265–277 (2012).",{"doi":2282},"10.1038\u002Fnrc3258",{"id":26,"text":2284,"url":26,"identifiers":2285},"Grivennikov, S.I., Greten, F.R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883–899 (2010).",{"doi":2286},"10.1016\u002Fj.cell.2010.01.025",{"id":26,"text":2288,"url":26,"identifiers":2289},"Sangiovanni, A. et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 126, 1005–1014 (2004).",{"doi":2290},"10.1053\u002Fj.gastro.2003.12.049",{"id":26,"text":2292,"url":26,"identifiers":2293},"Beaugerie, L. et al. Risk of colorectal high-grade dysplasia and cancer in a prospective observational cohort of patients with inflammatory bowel disease. Gastroenterology 145, 166–175 (2013).",{"doi":2294},"10.1053\u002Fj.gastro.2013.03.044",{"id":26,"text":2296,"url":26,"identifiers":2297},"Barcellos-Hoff, M.H., Lyden, D. & Wang, T.C. The evolution of the cancer niche during multistage carcinogenesis. Nat. Rev. Cancer 13, 511–518 (2013).",{"doi":2298},"10.1038\u002Fnrc3536",{"id":26,"text":2300,"url":26,"identifiers":2301},"de Martel, C. et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 13, 607–615 (2012).",{"doi":2302},"10.1016\u002FS1470-2045(12)70137-7",{"id":26,"text":2304,"url":26,"identifiers":2305},"Stewart, T., Tsai, S.C., Grayson, H., Henderson, R. & Opelz, G. Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation. Lancet 346, 796–798 (1995).",{"doi":2306},"10.1016\u002FS0140-6736(95)91618-0",{"id":26,"text":2308,"url":26,"identifiers":2309},"Gallagher, B., Wang, Z., Schymura, M.J., Kahn, A. & Fordyce, E.J. Cancer incidence in New York State acquired immunodeficiency syndrome patients. Am. J. Epidemiol. 154, 544–556 (2001).",{"doi":2310},"10.1093\u002Faje\u002F154.6.544",{"id":26,"text":2312,"url":26,"identifiers":2313},"Schulz, T.F. Cancer and viral infections in immunocompromised individuals. Int. J. Cancer 125, 1755–1763 (2009).",{"doi":2314},"10.1002\u002Fijc.24741",{"id":26,"text":2316,"url":26,"identifiers":2317},"Vajdic, C.M. & van Leeuwen, M.T. Cancer incidence and risk factors after solid organ transplantation. Int. J. Cancer 125, 1747–1754 (2009).",{"doi":2318},"10.1002\u002Fijc.24439",{"id":26,"text":2320,"url":26,"identifiers":2321},"Biswas, S.K. & Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 11, 889–896 (2010).",{"doi":2322},"10.1038\u002Fni.1937",{"id":26,"text":2324,"url":26,"identifiers":2325},"Flavell, R.A., Sanjabi, S., Wrzesinski, S.H. & Licona-Limon, P. The polarization of immune cells in the tumour environment by TGFβ. Nat. Rev. Immunol. 10, 554–567 (2010).",{"doi":2326},"10.1038\u002Fnri2808",{"id":26,"text":2328,"url":26,"identifiers":2329},"Wang, H.W. & Joyce, J.A. Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions. Cell Cycle 9, 4824–4835 (2010).",{"doi":2330},"10.4161\u002Fcc.9.24.14322",{"id":26,"text":2332,"url":26,"identifiers":2333},"Hagemann, T. et al. “Re-educating” tumor-associated macrophages by targeting NF-κB. J. Exp. Med. 205, 1261–1268 (2008).",{"doi":2334},"10.1084\u002Fjem.20080108",{"id":26,"text":2336,"url":26,"identifiers":2337},"Pyonteck, S.M. et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat. Med. 19, 1264–1272 (2013).",{"doi":2338},"10.1038\u002Fnm.3337",{"id":26,"text":2340,"url":26,"identifiers":2341},"Cook, J. & Hagemann, T. Tumour-associated macrophages and cancer. Curr. Opin. Pharmacol. 13, 595–601 (2013).",{"doi":2342},"10.1016\u002Fj.coph.2013.05.017",{"id":26,"text":2344,"url":26,"identifiers":2345},"Bissell, M.J. & Hines, W.C. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat. Med. 17, 320–329 (2011).",{"doi":2346},"10.1038\u002Fnm.2328",{"id":26,"text":2348,"url":26,"identifiers":2349},"Egeblad, M., Nakasone, E.S. & Werb, Z. Tumors as organs: complex tissues that interface with the entire organism. Dev. Cell 18, 884–901 (2010).",{"doi":2350},"10.1016\u002Fj.devcel.2010.05.012",{"id":26,"text":2352,"url":26,"identifiers":2353},"Qian, B.Z. & Pollard, J.W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39–51 (2010).",{"doi":2354},"10.1016\u002Fj.cell.2010.03.014",{"id":26,"text":2356,"url":26,"identifiers":2357},"Condeelis, J. & Pollard, J.W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263–266 (2006).",{"doi":2358},"10.1016\u002Fj.cell.2006.01.007",{"id":26,"text":2360,"url":26,"identifiers":2361},"Goswami, S. et al. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1\u002Fepidermal growth factor paracrine loop. Cancer Res. 65, 5278–5283 (2005).",{"doi":2362},"10.1158\u002F0008-5472.CAN-04-1853",{"id":26,"text":2364,"url":26,"identifiers":2365},"Coniglio, S.J. et al. Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol. Med. 18, 519–527 (2012).",{"doi":2366},"10.2119\u002Fmolmed.2011.00217",{"id":26,"text":2368,"url":26,"identifiers":2369},"Joyce, J.A. et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5, 443–453 (2004).",{"doi":2370},"10.1016\u002FS1535-6108(04)00111-4",{"id":26,"text":2372,"url":26,"identifiers":2373},"Gocheva, V. et al. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24, 241–255 (2010).",{"doi":2374},"10.1101\u002Fgad.1874010",{"id":26,"text":2376,"url":26,"identifiers":2377},"Shree, T. et al. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev. 25, 2465–2479 (2011).",{"doi":2378},"10.1101\u002Fgad.180331.111",{"id":26,"text":2380,"url":26,"identifiers":2381},"Mosser, D.M. & Edwards, J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958–969 (2008).",{"doi":2382},"10.1038\u002Fnri2448",{"id":26,"text":2384,"url":26,"identifiers":2385},"Lewis, C. & Murdoch, C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am. J. Pathol. 167, 627–635 (2005).",{"doi":2386},"10.1016\u002FS0002-9440(10)62038-X",{"id":26,"text":2388,"url":26,"identifiers":2389},"Escribese, M.M., Casas, M. & Corbi, A.L. Influence of low oxygen tensions on macrophage polarization. Immunobiology 217, 1233–1240 (2012).",{"doi":2390},"10.1016\u002Fj.imbio.2012.07.002",{"id":26,"text":2392,"url":26,"identifiers":2393},"Shime, H. et al. Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc. Natl. Acad. Sci. USA 109, 2066–2071 (2012).",{"doi":2394},"10.1073\u002Fpnas.1113099109",{"id":26,"text":2396,"url":26,"identifiers":2397},"Cai, X. et al. Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155. J. Mol. Cell Biol. 4, 341–343 (2012).",{"doi":2398},"10.1093\u002Fjmcb\u002Fmjs044",{"id":26,"text":2400,"url":26,"identifiers":2401},"Motz, G.T. & Coukos, G. Deciphering and reversing tumor immune suppression. Immunity 39, 61–73 (2013).",{"doi":2402},"10.1016\u002Fj.immuni.2013.07.005",{"id":26,"text":2404,"url":26,"identifiers":2405},"Almand, B. et al. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J. Immunol. 166, 678–689 (2001).",{"doi":2406},"10.4049\u002Fjimmunol.166.1.678",{"id":26,"text":2408,"url":26,"identifiers":2409},"Talmadge, J.E. & Gabrilovich, D.I. History of myeloid-derived suppressor cells. Nat. Rev. Cancer 13, 739–752 (2013).",{"doi":2410},"10.1038\u002Fnrc3581",{"id":26,"text":2412,"url":26,"identifiers":2413},"Gabrilovich, D.I., Ostrand-Rosenberg, S. & Bronte, V. Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253–268 (2012).",{"doi":2414},"10.1038\u002Fnri3175",{"id":26,"text":2416,"url":26,"identifiers":2417},"Mazzoni, A. et al. Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism. J. Immunol. 168, 689–695 (2002).",{"doi":2418},"10.4049\u002Fjimmunol.168.2.689",{"id":26,"text":2420,"url":26,"identifiers":2421},"Gabrilovich, D.I., Velders, M.P., Sotomayor, E.M. & Kast, W.M. Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells. J. Immunol. 166, 5398–5406 (2001).",{"doi":2422},"10.4049\u002Fjimmunol.166.9.5398",{"id":26,"text":2424,"url":26,"identifiers":2425},"Sinha, P., Clements, V.K. & Ostrand-Rosenberg, S. Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J. Immunol. 174, 636–645 (2005).",{"doi":2426},"10.4049\u002Fjimmunol.174.2.636",{"id":26,"text":2428,"url":26,"identifiers":2429},"Liu, C. et al. Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host. Blood 109, 4336–4342 (2007).",{"doi":2430},"10.1182\u002Fblood-2006-09-046201",{"id":26,"text":2432,"url":26,"identifiers":2433},"Diaz-Montero, C.M. et al. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol. Immunother. 58, 49–59 (2009).",{"doi":2434},"10.1007\u002Fs00262-008-0523-4",{"id":26,"text":2436,"url":26,"identifiers":2437},"Shirota, Y., Shirota, H. & Klinman, D.M. Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells. J. Immunol. 188, 1592–1599 (2012).",{"doi":2438},"10.4049\u002Fjimmunol.1101304",{"id":26,"text":2440,"url":26,"identifiers":2441},"Whiteside, T.L., Schuler, P. & Schilling, B. Induced and natural regulatory T cells in human cancer. Expert Opin. Biol. Ther. 12, 1383–1397 (2012).",{"doi":2442},"10.1517\u002F14712598.2012.707184",{"id":26,"text":2444,"url":26,"identifiers":2445},"Gasteiger, G. et al. IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J. Exp. Med. 210, 1179–1187 (2013).",{"doi":2446},"10.1084\u002Fjem.20122571",{"id":26,"text":2448,"url":26,"identifiers":2449},"Bates, G.J. et al. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J. Clin. Oncol. 24, 5373–5380 (2006).",{"doi":2450},"10.1200\u002FJCO.2006.05.9584",{"id":26,"text":2452,"url":26,"identifiers":2453},"Fu, J. et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 132, 2328–2339 (2007).",{"doi":2454},"10.1053\u002Fj.gastro.2007.03.102",{"id":26,"text":2456,"url":26,"identifiers":2457},"Frey, D.M. et al. High frequency of tumor-infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. Int. J. Cancer 126, 2635–2643 (2010).",{"doi":2458},"10.1002\u002Fijc.24989",{"id":26,"text":2460,"url":26,"identifiers":2461},"von Boehmer, H. & Daniel, C. Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer. Nat. Rev. Drug Discov. 12, 51–63 (2013).",{"doi":2462},"10.1038\u002Fnrd3683",{"id":26,"text":2464,"url":26,"identifiers":2465},"Fridman, W.H., Pages, F., Sautes-Fridman, C. & Galon, J. The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12, 298–306 (2012).",{"doi":2466},"10.1038\u002Fnrc3245",{"id":26,"text":2468,"url":26,"identifiers":2469},"Blatner, N.R. et al. Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer. Sci. Transl. Med. 4, 164ra159 (2012).",{"doi":2470},"10.1126\u002Fscitranslmed.3004566",{"id":26,"text":2472,"url":26,"identifiers":2473},"Rech, A.J. et al. CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci. Transl. Med. 4, 134ra162 (2012).",{"doi":2474},"10.1126\u002Fscitranslmed.3003330",{"id":26,"text":2476,"url":26,"identifiers":2477},"Tomasek, J.J., Gabbiani, G., Hinz, B., Chaponnier, C. & Brown, R.A. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat. Rev. Mol. Cell Biol. 3, 349–363 (2002).",{"doi":2478},"10.1038\u002Fnrm809",{"id":26,"text":2480,"url":26,"identifiers":2481},"Kalluri, R. & Zeisberg, M. Fibroblasts in cancer. Nat. Rev. Cancer 6, 392–401 (2006).",{"doi":2482},"10.1038\u002Fnrc1877",{"id":26,"text":2484,"url":26,"identifiers":2485},"Olumi, A.F. et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002–5011 (1999).",{},{"id":26,"text":2487,"url":26,"identifiers":2488},"Dumont, N. et al. Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia 15, 249–262 (2013).",{"doi":2489},"10.1593\u002Fneo.121950",{"id":26,"text":2491,"url":26,"identifiers":2492},"Marsh, T., Pietras, K. & McAllister, S.S. Fibroblasts as architects of cancer pathogenesis. Biochim. Biophys. Acta 1832, 1070–1078 (2013).",{"doi":2493},"10.1016\u002Fj.bbadis.2012.10.013",{"id":26,"text":2495,"url":26,"identifiers":2496},"Zeisberg, E.M., Potenta, S., Xie, L., Zeisberg, M. & Kalluri, R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 67, 10123–10128 (2007).",{"doi":2497},"10.1158\u002F0008-5472.CAN-07-3127",{"id":26,"text":2499,"url":26,"identifiers":2500},"Petersen, O.W. et al. Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am. J. Pathol. 162, 391–402 (2003).",{"doi":2501},"10.1016\u002FS0002-9440(10)63834-5",{"id":26,"text":2503,"url":26,"identifiers":2504},"Orr, B. et al. Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate. Oncogene 31, 1130–1142 (2012).",{"doi":2505},"10.1038\u002Fonc.2011.312",{"id":26,"text":2507,"url":26,"identifiers":2508},"Zeisberg, M. et al. BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med. 9, 964–968 (2003).",{"doi":2509},"10.1038\u002Fnm888",{"id":26,"text":2511,"url":26,"identifiers":2512},"Calvo, F. et al. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat. Cell Biol. 15, 637–646 (2013).",{"doi":2513},"10.1038\u002Fncb2756",{"id":26,"text":1356,"url":26,"identifiers":2515},{"doi":1358},{"id":26,"text":2517,"url":26,"identifiers":2518},"Erez, N., Truitt, M., Olson, P., Arron, S.T. & Hanahan, D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB–dependent manner. Cancer Cell 17, 135–147 (2010).",{"doi":2519},"10.1016\u002Fj.ccr.2009.12.041",{"id":26,"text":2521,"url":26,"identifiers":2522},"Zhang, X.H. et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell 154, 1060–1073 (2013).",{"doi":2523},"10.1016\u002Fj.cell.2013.07.036",{"id":26,"text":2525,"url":26,"identifiers":2526},"Bergamaschi, A. et al. Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome. J. Pathol. 214, 357–367 (2008).",{"doi":2527},"10.1002\u002Fpath.2278",{"id":26,"text":2529,"url":26,"identifiers":2530},"Naba, A. et al. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell. Proteomics 11, M111.014647 (2012).",{"doi":2531},"10.1074\u002Fmcp.M111.014647",{"id":26,"text":2533,"url":26,"identifiers":2534},"Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182–1186 (1971).",{"doi":2535},"10.1056\u002FNEJM197108122850711",{"id":26,"text":2537,"url":26,"identifiers":2538},"Du, R. et al. HIF1α induces the recruitment of bone marrow–derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13, 206–220 (2008).",{"doi":2539},"10.1016\u002Fj.ccr.2008.01.034",{"id":26,"text":2541,"url":26,"identifiers":2542},"Semenza, G.L. Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene 32, 4057–4063 (2013).",{"doi":2543},"10.1038\u002Fonc.2012.578",{"id":26,"text":2545,"url":26,"identifiers":2546},"Zhu, W. et al. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp. Mol. Pathol. 80, 267–274 (2006).",{"doi":2547},"10.1016\u002Fj.yexmp.2005.07.004",{"id":26,"text":2549,"url":26,"identifiers":2550},"Ho, I.A. et al. Human bone marrow–derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis. Stem Cells 31, 146–155 (2013).",{"doi":2551},"10.1002\u002Fstem.1247",{"id":26,"text":2553,"url":26,"identifiers":2554},"Roodhart, J.M. et al. Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell 20, 370–383 (2011).",{"doi":2555},"10.1016\u002Fj.ccr.2011.08.010",{"id":26,"text":2557,"url":26,"identifiers":2558},"Cuiffo, B.G. & Karnoub, A.E. Mesenchymal stem cells in tumor development: emerging roles and concepts. Cell Adh. Migr. 6, 220–230 (2012).",{"doi":2559},"10.4161\u002Fcam.20875",{"id":26,"text":2561,"url":26,"identifiers":2562},"Alitalo, A. & Detmar, M. Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene 31, 4499–4508 (2012).",{"doi":2563},"10.1038\u002Fonc.2011.602",{"id":26,"text":2565,"url":26,"identifiers":2566},"Schoppmann, S.F. et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am. J. Pathol. 161, 947–956 (2002).",{"doi":2567},"10.1016\u002FS0002-9440(10)64255-1",{"id":26,"text":2569,"url":26,"identifiers":2570},"Kerjaschki, D. et al. Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants. Nat. Med. 12, 230–234 (2006).",{"doi":2571},"10.1038\u002Fnm1340",{"id":26,"text":2573,"url":26,"identifiers":2574},"Zumsteg, A. et al. Myeloid cells contribute to tumor lymphangiogenesis. PLoS ONE 4, e7067 (2009).",{"doi":2575},"10.1371\u002Fjournal.pone.0007067",{"id":26,"text":2577,"url":26,"identifiers":2578},"Hunter, K.E. et al. Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors. Oncogene published online, doi:10.1038\u002Fonc.2013.142 (6 May 2013).",{"doi":2579},"10.1038\u002Fonc.2013.14",{"id":26,"text":2581,"url":26,"identifiers":2582},"Psaila, B. & Lyden, D. The metastatic niche: adapting the foreign soil. Nat. Rev. Cancer 9, 285–293 (2009).",{"doi":2583},"10.1038\u002Fnrc2621",{"id":26,"text":2585,"url":26,"identifiers":2586},"Mani, S.A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704–715 (2008).",{"doi":2587},"10.1016\u002Fj.cell.2008.03.027",{"id":26,"text":2589,"url":26,"identifiers":2590},"Thiery, J.P., Acloque, H., Huang, R.Y. & Nieto, M.A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871–890 (2009).",{"doi":2591},"10.1016\u002Fj.cell.2009.11.007",{"id":26,"text":2593,"url":26,"identifiers":2594},"Gao, D. et al. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res. 72, 1384–1394 (2012).",{"doi":2595},"10.1158\u002F0008-5472.CAN-11-2905",{"id":26,"text":2597,"url":26,"identifiers":2598},"Chao, Y., Wu, Q., Acquafondata, M., Dhir, R. & Wells, A. Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases. Cancer Microenviron. 5, 19–28 (2012).",{"doi":2599},"10.1007\u002Fs12307-011-0085-4",{"id":26,"text":2601,"url":26,"identifiers":2602},"Chaffer, C.L., Thompson, E.W. & Williams, E.D. Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 185, 7–19 (2007).",{"doi":2603},"10.1159\u002F000101298",{"id":26,"text":2605,"url":26,"identifiers":2606},"Bonde, A.K., Tischler, V., Kumar, S., Soltermann, A. & Schwendener, R.A. Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer 12, 35 (2012).",{"doi":2607},"10.1186\u002F1471-2407-12-35",{"id":26,"text":2609,"url":26,"identifiers":2610},"Gay, L.J. & Felding-Habermann, B. Contribution of platelets to tumour metastasis. Nat. Rev. Cancer 11, 123–134 (2011).",{"doi":2611},"10.1038\u002Fnrc3004",{"id":26,"text":2613,"url":26,"identifiers":2614},"Labelle, M., Begum, S. & Hynes, R.O. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal–like transition and promotes metastasis. Cancer Cell 20, 576–590 (2011).",{"doi":2615},"10.1016\u002Fj.ccr.2011.09.009",{"id":26,"text":2617,"url":26,"identifiers":2618},"Nishimura, K., Semba, S., Aoyagi, K., Sasaki, H. & Yokozaki, H. Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells. Pathobiology 79, 290–306 (2012).",{"doi":2619},"10.1159\u002F000337296",{"id":26,"text":2621,"url":26,"identifiers":2622},"Condeelis, J. & Segall, J.E. Intravital imaging of cell movement in tumours. Nat. Rev. Cancer 3, 921–930 (2003).",{"doi":2623},"10.1038\u002Fnrc1231",{"id":26,"text":2625,"url":26,"identifiers":2626},"Wyckoff, J.B. et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67, 2649–2656 (2007).",{"doi":2627},"10.1158\u002F0008-5472.CAN-06-1823",{"id":26,"text":2629,"url":26,"identifiers":2630},"van Zijl, F. et al. Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 28, 4022–4033 (2009).",{"doi":2631},"10.1038\u002Fonc.2009.253",{"id":26,"text":2633,"url":26,"identifiers":2634},"Chouaib, S. et al. Hypoxia promotes tumor growth in linking angiogenesis to immune escape. Front. Immunol. 3, 21 (2012).",{"doi":2635},"10.3389\u002Ffimmu.2012.00021",{"id":26,"text":2637,"url":26,"identifiers":2638},"Facciabene, A. et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells. Nature 475, 226–230 (2011).",{"doi":2639},"10.1038\u002Fnature10169",{"id":26,"text":2641,"url":26,"identifiers":2642},"Corzo, C.A. et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207, 2439–2453 (2010).",{"doi":2643},"10.1084\u002Fjem.20100587",{"id":26,"text":2645,"url":26,"identifiers":2646},"Halama, N. et al. Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy. Cancer Res. 71, 5670–5677 (2011).",{"doi":2647},"10.1158\u002F0008-5472.CAN-11-0268",{"id":26,"text":2649,"url":26,"identifiers":2650},"Murdoch, C., Giannoudis, A. & Lewis, C.E. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104, 2224–2234 (2004).",{"doi":2651},"10.1182\u002Fblood-2004-03-1109",{"id":26,"text":2653,"url":26,"identifiers":2654},"Nguyen, D.X., Bos, P.D. & Massague, J. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 9, 274–284 (2009).",{"doi":2655},"10.1038\u002Fnrc2622",{"id":26,"text":2657,"url":26,"identifiers":2658},"Condeelis, J. & Weissleder, R. In vivo imaging in cancer. Cold Spring Harb. Perspect. Biol. 2, a003848 (2010).",{"doi":2659},"10.1101\u002Fcshperspect.a003848",{"id":26,"text":2661,"url":26,"identifiers":2662},"Sidani, M., Wyckoff, J., Xue, C., Segall, J.E. & Condeelis, J. Probing the microenvironment of mammary tumors using multiphoton microscopy. J. Mammary Gland Biol. Neoplasia 11, 151–163 (2006).",{"doi":2663},"10.1007\u002Fs10911-006-9021-5",{"id":26,"text":2665,"url":26,"identifiers":2666},"Robinson, B.D. et al. Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin. Cancer Res. 15, 2433–2441 (2009).",{"doi":2667},"10.1158\u002F1078-0432.CCR-08-2179",{"id":26,"text":2669,"url":26,"identifiers":2670},"Lucci, A. et al. Circulating tumour cells in non-metastatic breast cancer: a prospective study. Lancet Oncol. 13, 688–695 (2012).",{"doi":2671},"10.1016\u002FS1470-2045(12)70209-7",{"id":26,"text":2673,"url":26,"identifiers":2674},"Krishnamurthy, S. et al. Detection of minimal residual disease in blood and bone marrow in early stage breast cancer. Cancer 116, 3330–3337 (2010).",{"doi":2675},"10.1002\u002Fcncr.25145",{"id":26,"text":2677,"url":26,"identifiers":2678},"Stoecklein, N.H. et al. Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. Cancer Cell 13, 441–453 (2008).",{"doi":2679},"10.1016\u002Fj.ccr.2008.04.005",{"id":26,"text":2681,"url":26,"identifiers":2682},"Redente, E.F. et al. Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow–derived monocyte polarization. Am. J. Pathol. 176, 2972–2985 (2010).",{"doi":2683},"10.2353\u002Fajpath.2010.090879",{"id":26,"text":2685,"url":26,"identifiers":2686},"Chambers, A.F. et al. Critical steps in hematogenous metastasis: an overview. Surg. Oncol. Clin. N. Am. 10, 243–255, vii (2001).",{"doi":2687},"10.1016\u002FS1055-3207(18)30063-2",{"id":26,"text":2689,"url":26,"identifiers":2690},"Palumbo, J.S. et al. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells. Blood 105, 178–185 (2005).",{"doi":2691},"10.1182\u002Fblood-2004-06-2272",{"id":26,"text":2693,"url":26,"identifiers":2694},"Ruggeri, Z.M. & Mendolicchio, G.L. Adhesion mechanisms in platelet function. Circ. Res. 100, 1673–1685 (2007).",{"doi":2695},"10.1161\u002F01.RES.0000267878.97021.ab",{"id":26,"text":2697,"url":26,"identifiers":2698},"Schumacher, D., Strilic, B., Sivaraj, K.K., Wettschureck, N. & Offermanns, S. Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24, 130–137 (2013).",{"doi":2699},"10.1016\u002Fj.ccr.2013.05.008",{"id":26,"text":2701,"url":26,"identifiers":2702},"Taucher, S. et al. Impact of pretreatment thrombocytosis on survival in primary breast cancer. Thromb. Haemost. 89, 1098–1106 (2003).",{"doi":2703},"10.1055\u002Fs-0037-1613413",{"id":26,"text":2705,"url":26,"identifiers":2706},"Brown, K.M., Domin, C., Aranha, G.V., Yong, S. & Shoup, M. Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. Am. J. Surg. 189, 278–282 (2005).",{"doi":2707},"10.1016\u002Fj.amjsurg.2004.11.014",{"id":26,"text":2709,"url":26,"identifiers":2710},"Brockmann, M.A. et al. Preoperative thrombocytosis predicts poor survival in patients with glioblastoma. Neuro-oncol. 9, 335–342 (2007).",{"doi":2711},"10.1215\u002F15228517-2007-013",{"id":26,"text":2713,"url":26,"identifiers":2714},"Kaplan, R.N. et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820–827 (2005).",{"doi":2715},"10.1038\u002Fnature04186",{"id":26,"text":2717,"url":26,"identifiers":2718},"Chen, Q., Zhang, X.H. & Massague, J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20, 538–549 (2011).",{"doi":2719},"10.1016\u002Fj.ccr.2011.08.025",{"id":26,"text":2721,"url":26,"identifiers":2722},"Lu, X. et al. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell 20, 701–714 (2011).",{"doi":2723},"10.1016\u002Fj.ccr.2011.11.002",{"id":26,"text":2725,"url":26,"identifiers":2726},"Erler, J.T. et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222–1226 (2006).",{"doi":2727},"10.1038\u002Fnature04695",{"id":26,"text":2729,"url":26,"identifiers":2730},"Sceneay, J. et al. Primary tumor hypoxia recruits CD11b+\u002FLy6Cmed\u002FLy6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche. Cancer Res. 72, 3906–3911 (2012).",{"doi":2731},"10.1158\u002F0008-5472.CAN-11-3873",{"id":26,"text":2733,"url":26,"identifiers":2734},"Malanchi, I. et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481, 85–89 (2012).",{"doi":2735},"10.1038\u002Fnature10694",{"id":26,"text":2737,"url":26,"identifiers":2738},"Peinado, H. et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883–891 (2012).",{"doi":2739},"10.1038\u002Fnm.2753",{"id":26,"text":2741,"url":26,"identifiers":2742},"Luga, V. et al. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 151, 1542–1556 (2012).",{"doi":2743},"10.1016\u002Fj.cell.2012.11.024",{"id":26,"text":2745,"url":26,"identifiers":2746},"Lugini, L. et al. Immune surveillance properties of human NK cell–derived exosomes. J. Immunol. 189, 2833–2842 (2012).",{"doi":2747},"10.4049\u002Fjimmunol.1101988",{"id":26,"text":2749,"url":26,"identifiers":2750},"Morse, M.A. et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med. 3, 9 (2005).",{"doi":2751},"10.1186\u002F1479-5876-3-9",{"id":26,"text":2753,"url":26,"identifiers":2754},"Escudier, B. et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J. Transl. Med. 3, 10 (2005).",{"doi":2755},"10.1186\u002F1479-5876-3-10",{"id":26,"text":2757,"url":26,"identifiers":2758},"Näslund, T.I., Gehrmann, U., Qazi, K.R., Karlsson, M.C. & Gabrielsson, S. Dendritic cell–derived exosomes need to activate both T and B cells to induce antitumor immunity. J. Immunol. 190, 2712–2719 (2013).",{"doi":2759},"10.4049\u002Fjimmunol.1203082",{"id":26,"text":2761,"url":26,"identifiers":2762},"Granot, Z. et al. Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20, 300–314 (2011).",{"doi":2763},"10.1016\u002Fj.ccr.2011.08.012",{"id":26,"text":2765,"url":26,"identifiers":2766},"Catena, R. et al. Bone marrow–derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1. Cancer Discov. 3, 578–589 (2013).",{"doi":2767},"10.1158\u002F2159-8290.CD-12-0476",{"id":26,"text":2769,"url":26,"identifiers":2770},"Aguirre-Ghiso, J.A. Models, mechanisms and clinical evidence for cancer dormancy. Nat. Rev. Cancer 7, 834–846 (2007).",{"doi":2771},"10.1038\u002Fnrc2256",{"id":26,"text":2773,"url":26,"identifiers":2774},"Schreiber, R.D., Old, L.J. & Smyth, M.J. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331, 1565–1570 (2011).",{"doi":2775},"10.1126\u002Fscience.1203486",{"id":26,"text":2777,"url":26,"identifiers":2778},"Hensel, J.A., Flaig, T.W. & Theodorescu, D. Clinical opportunities and challenges in targeting tumour dormancy. Nat. Rev. Clin. Oncol. 10, 41–51 (2013).",{"doi":2779},"10.1038\u002Fnrclinonc.2012.207",{"id":26,"text":2781,"url":26,"identifiers":2782},"Naumov, G.N., Akslen, L.A. & Folkman, J. Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle 5, 1779–1787 (2006).",{"doi":2783},"10.4161\u002Fcc.5.16.3018",{"id":26,"text":2785,"url":26,"identifiers":2786},"Ghajar, C.M. et al. The perivascular niche regulates breast tumour dormancy. Nat. Cell Biol. 15, 807–817 (2013).",{"doi":2787},"10.1038\u002Fncb2767",{"id":26,"text":2789,"url":26,"identifiers":2790},"Conejo-Garcia, J.R. et al. Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat. Med. 10, 950–958 (2004).",{"doi":2791},"10.1038\u002Fnm1097",{"id":26,"text":2793,"url":26,"identifiers":2794},"Gao, D. et al. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319, 195–198 (2008).",{"doi":2795},"10.1126\u002Fscience.1150224",{"id":26,"text":2797,"url":26,"identifiers":2798},"Lyden, D. et al. Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7, 1194–1201 (2001).",{"doi":2799},"10.1038\u002Fnm1101-1194",{"id":26,"text":2801,"url":26,"identifiers":2802},"Purhonen, S. et al. Bone marrow–derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc. Natl. Acad. Sci. USA 105, 6620–6625 (2008).",{"doi":2803},"10.1073\u002Fpnas.0710516105",{"id":26,"text":2805,"url":26,"identifiers":2806},"Dawson, M.R., Duda, D.G., Fukumura, D. & Jain, R.K. VEGFR1-activity–independent metastasis formation. Nature 461, E4 (2009).",{"doi":2807},"10.1038\u002Fnature08254",{"id":26,"text":2809,"url":26,"identifiers":2810},"Kerbel, R.S. et al. Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas. Proc. Natl. Acad. Sci. U S A 105, E54; author reply E55 (2008).",{"doi":2811},"10.1073\u002Fpnas.0804876105",{"id":26,"text":2813,"url":26,"identifiers":2814},"Pierga, J.Y. et al. Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer. Br. J. Cancer 89, 539–545 (2003).",{"doi":2815},"10.1038\u002Fsj.bjc.6601121",{"id":26,"text":2817,"url":26,"identifiers":2818},"Braun, S. et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N. Engl. J. Med. 342, 525–533 (2000).",{"doi":2819},"10.1056\u002FNEJM200002243420801",{"id":26,"text":2821,"url":26,"identifiers":2822},"Naumov, G.N. et al. Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res. 62, 2162–2168 (2002).",{},{"id":26,"text":2824,"url":26,"identifiers":2825},"Liu, D., Aguirre Ghiso, J., Estrada, Y. & Ossowski, L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1, 445–457 (2002).",{"doi":2826},"10.1016\u002FS1535-6108(02)00072-7",{"id":26,"text":2828,"url":26,"identifiers":2829},"Ranganathan, A.C., Adam, A.P. & Aguirre-Ghiso, J.A. Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. Cell Cycle 5, 1799–1807 (2006).",{"doi":2830},"10.4161\u002Fcc.5.16.3109",{"id":26,"text":2832,"url":26,"identifiers":2833},"Lujambio, A. et al. Non–cell-autonomous tumor suppression by p53. Cell 153, 449–460 (2013).",{"doi":2834},"10.1016\u002Fj.cell.2013.03.020",{"id":26,"text":2836,"url":26,"identifiers":2837},"Gao, H. et al. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell 150, 764–779 (2012).",{"doi":2838},"10.1016\u002Fj.cell.2012.06.035",{"id":26,"text":2840,"url":26,"identifiers":2841},"Shankaran, V. et al. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410, 1107–1111 (2001).",{"doi":2842},"10.1038\u002F35074122",{"id":26,"text":2844,"url":26,"identifiers":2845},"Koebel, C.M. et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450, 903–907 (2007).",{"doi":2846},"10.1038\u002Fnature06309",{"id":26,"text":2848,"url":26,"identifiers":2849},"Khong, H.T. & Restifo, N.P. Natural selection of tumor variants in the generation of “tumor escape” phenotypes. Nat. Immunol. 3, 999–1005 (2002).",{"doi":2850},"10.1038\u002Fni1102-999",{"id":26,"text":2852,"url":26,"identifiers":2853},"Vanneman, M. & Dranoff, G. Combining immunotherapy and targeted therapies in cancer treatment. Nat. Rev. Cancer 12, 237–251 (2012).",{"doi":2854},"10.1038\u002Fnrc3237",{"id":26,"text":2856,"url":26,"identifiers":2857},"Yoshikawa, K. et al. Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head. Cancer Sci. 103, 2012–2020 (2012).",{"doi":2858},"10.1111\u002Fj.1349-7006.2012.02411.x",{"id":26,"text":2860,"url":26,"identifiers":2861},"Qian, B. et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS ONE 4, e6562 (2009).",{"doi":2862},"10.1371\u002Fjournal.pone.0006562",{"id":26,"text":2864,"url":26,"identifiers":2865},"Qian, B.Z. et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475, 222–225 (2011).",{"doi":2866},"10.1038\u002Fnature10138",{"id":26,"text":2868,"url":26,"identifiers":2869},"Mantovani, G. et al. Tumor-associated lympho-monocytes from neoplastic effusions are immunologically defective in comparison with patient autologous PBMCs but are capable of releasing high amounts of various cytokines. Int. J. Cancer 71, 724–731 (1997).",{"doi":2870},"10.1002\u002F(SICI)1097-0215(19970529)71:5\u003C724::AID-IJC6>3.0.CO;2-T",{"id":26,"text":2872,"url":26,"identifiers":2873},"Gil-Bernabé, A.M. et al. Recruitment of monocytes\u002Fmacrophages by tissue factor–mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood 119, 3164–3175 (2012).",{"doi":2874},"10.1182\u002Fblood-2011-08-376426",{"id":26,"text":2876,"url":26,"identifiers":2877},"Palumbo, J.S. Mechanisms linking tumor cell–associated procoagulant function to tumor dissemination. Semin. Thromb. Hemost. 34, 154–160 (2008).",{"doi":2878},"10.1055\u002Fs-2008-1079255",{"id":26,"text":2880,"url":26,"identifiers":2881},"Amirkhosravi, A. et al. Tissue factor pathway inhibitor reduces experimental lung metastasis of B16 melanoma. Thromb. Haemost. 87, 930–936 (2002).",{"doi":2882},"10.1055\u002Fs-0037-1613114",{"id":26,"text":2884,"url":26,"identifiers":2885},"Marusyk, A., Almendro, V. & Polyak, K. Intra-tumour heterogeneity: a looking glass for cancer? Nat. Rev. Cancer 12, 323–334 (2012).",{"doi":2886},"10.1038\u002Fnrc3261",{"id":26,"text":2888,"url":26,"identifiers":2889},"Garraway, L.A. & Lander, E.S. Lessons from the cancer genome. Cell 153, 17–37 (2013).",{"doi":2890},"10.1016\u002Fj.cell.2013.03.002",{"id":26,"text":2892,"url":26,"identifiers":2893},"Fang, H. & Declerck, Y.A. Targeting the tumor microenvironment: from understanding pathways to effective clinical trials. Cancer Res. 73, 4965–4977 (2013).",{"doi":2894},"10.1158\u002F0008-5472.CAN-13-0661",{"id":26,"text":2896,"url":26,"identifiers":2897},"Carmeliet, P. & Jain, R.K. Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298–307 (2011).",{"doi":2898},"10.1038\u002Fnature10144",{"id":26,"text":2900,"url":26,"identifiers":2901},"Sharma, P., Wagner, K., Wolchok, J.D. & Allison, J.P. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat. Rev. Cancer 11, 805–812 (2011).",{"doi":2902},"10.1038\u002Fnrc3153",{"id":26,"text":2904,"url":26,"identifiers":2905},"Restifo, N.P., Dudley, M.E. & Rosenberg, S.A. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat. Rev. Immunol. 12, 269–281 (2012).",{"doi":2906},"10.1038\u002Fnri3191",{"id":26,"text":2908,"url":26,"identifiers":2909},"Hodi, F.S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711–723 (2010).",{"doi":2910},"10.1056\u002FNEJMoa1003466",{"id":26,"text":2912,"url":26,"identifiers":2913},"Hwu, P. Treating cancer by targeting the immune system. N. Engl. J. Med. 363, 779–781 (2010).",{"doi":2914},"10.1056\u002FNEJMe1006416",{"id":26,"text":2916,"url":26,"identifiers":2917},"Wolchok, J.D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122–133 (2013).",{"doi":2918},"10.1056\u002FNEJMoa1302369",{"id":26,"text":2920,"url":26,"identifiers":2921},"Hamid, O. et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369, 134–144 (2013).",{"doi":2922},"10.1056\u002FNEJMoa1305133",{"id":26,"text":2924,"url":26,"identifiers":2925},"Vonderheide, R.H. & Glennie, M.J. Agonistic CD40 antibodies and cancer therapy. Clin. Cancer Res. 19, 1035–1043 (2013).",{"doi":2926},"10.1158\u002F1078-0432.CCR-12-2064",{"id":26,"text":2928,"url":26,"identifiers":2929},"Beatty, G.L. et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331, 1612–1616 (2011).",{"doi":2930},"10.1126\u002Fscience.1198443",{"id":26,"text":2932,"url":26,"identifiers":2933},"Coussens, L.M., Zitvogel, L. & Palucka, A.K. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science 339, 286–291 (2013).",{"doi":2934},"10.1126\u002Fscience.1232227",{"id":26,"text":2936,"url":26,"identifiers":2937},"DeNardo, D.G. et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1, 54–67 (2011).",{"doi":2938},"10.1158\u002F2159-8274.CD-10-0028",{"id":26,"text":2940,"url":26,"identifiers":2941},"Germano, G. et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell 23, 249–262 (2013).",{"doi":2942},"10.1016\u002Fj.ccr.2013.01.008",{"id":26,"text":2944,"url":26,"identifiers":2945},"Murdoch, C., Muthana, M., Coffelt, S.B. & Lewis, C.E. The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8, 618–631 (2008).",{"doi":2946},"10.1038\u002Fnrc2444",{"id":26,"text":2948,"url":26,"identifiers":2949},"Fridlender, Z.G. & Albelda, S.M. Tumor-associated neutrophils: friend or foe? Carcinogenesis 33, 949–955 (2012).",{"doi":2950},"10.1093\u002Fcarcin\u002Fbgs123",{"id":26,"text":2952,"url":26,"identifiers":2953},"Vivier, E., Tomasello, E., Baratin, M., Walzer, T. & Ugolini, S. Functions of natural killer cells. Nat. Immunol. 9, 503–510 (2008).",{"doi":2954},"10.1038\u002Fni1582",{"id":26,"text":2956,"url":26,"identifiers":2957},"Bos, P.D. & Rudensky, A.Y. Treg cells in cancer: a case of multiple personality disorder. Sci. Transl. Med. 4, 164fs144 (2012).",{"doi":2958},"10.1126\u002Fscitranslmed.3005283",{"id":26,"text":2960,"url":26,"identifiers":2961},"Mahmoud, S.M. et al. Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J. Clin. Oncol. 29, 1949–1955 (2011).",{"doi":2962},"10.1200\u002FJCO.2010.30.5037",{"id":26,"text":2964,"url":26,"identifiers":2965},"de Visser, K.E., Korets, L.V. & Coussens, L.M. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7, 411–423 (2005).",{"doi":2966},"10.1016\u002Fj.ccr.2005.04.014",{"id":26,"text":2968,"url":26,"identifiers":2969},"Calle, E.E., Rodriguez, C., Walker-Thurmond, K. & Thun, M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 348, 1625–1638 (2003).",{"doi":2970},"10.1056\u002FNEJMoa021423",{"id":26,"text":2972,"url":26,"identifiers":2973},"Behan, J.W. et al. Adipocytes impair leukemia treatment in mice. Cancer Res. 69, 7867–7874 (2009).",{"doi":2974},"10.1158\u002F0008-5472.CAN-09-0800",{"id":26,"text":2976,"url":26,"identifiers":2977},"Morris, P.G. et al. Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev. Res. (Phila.) 4, 1021–1029 (2011).",{"doi":2978},"10.1158\u002F1940-6207.CAPR-11-0110",{"id":26,"text":2980,"url":26,"identifiers":2981},"Nieman, K.M. et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat. Med. 17, 1498–1503 (2011).",{"doi":2982},"10.1038\u002Fnm.2492",{"id":26,"text":2984,"url":26,"identifiers":2985},"Zhang, Y. et al. Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Res. 72, 5198–5208 (2012).",{"doi":2986},"10.1158\u002F0008-5472.CAN-12-0294",{"id":26,"text":2988,"url":26,"identifiers":2989},"Katayama, Y. et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124, 407–421 (2006).",{"doi":2990},"10.1016\u002Fj.cell.2005.10.041",{"id":26,"text":2992,"url":26,"identifiers":2993},"Yamazaki, S. et al. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 147, 1146–1158 (2011).",{"doi":2994},"10.1016\u002Fj.cell.2011.09.053",{"id":26,"text":2996,"url":26,"identifiers":2997},"Liebig, C. et al. Perineural invasion is an independent predictor of outcome in colorectal cancer. J. Clin. Oncol. 27, 5131–5137 (2009).",{"doi":2998},"10.1200\u002FJCO.2009.22.4949",{"id":26,"text":3000,"url":26,"identifiers":3001},"Ayala, G.E. et al. Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin. Cancer Res. 14, 7593–7603 (2008).",{"doi":3002},"10.1158\u002F1078-0432.CCR-08-1164",{"id":26,"text":3004,"url":26,"identifiers":3005},"Demir, I.E., Friess, H. & Ceyhan, G.O. Nerve-cancer interactions in the stromal biology of pancreatic cancer. Front. Physiol. 3, 97 (2012).",{"doi":3006},"10.3389\u002Ffphys.2012.00097",{"id":26,"text":3008,"url":26,"identifiers":3009},"Magnon, C. et al. Autonomic nerve development contributes to prostate cancer progression. Science 341, 1236361 (2013).",{"doi":3010},"10.1126\u002Fscience.1236361",{"id":26,"text":3012,"url":26,"identifiers":3013},"Liao, X. et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N. Engl. J. Med. 367, 1596–1606 (2012).",{"doi":3014},"10.1056\u002FNEJMoa1207756",{"id":26,"text":3016,"url":26,"identifiers":3017},"Holmgaard, R.B., Zamarin, D., Munn, D.H., Wolchok, J.D. & Allison, J.P. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J. Exp. Med. 210, 1389–1402 (2013).",{"doi":3018},"10.1084\u002Fjem.20130066",{"id":26,"text":3020,"url":26,"identifiers":3021},"Landsberg, J. et al. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature 490, 412–416 (2012).",{"doi":3022},"10.1038\u002Fnature11538",{"id":26,"text":3024,"url":26,"identifiers":3025},"De Palma, M. & Lewis, C.E. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 23, 277–286 (2013).",{"doi":3026},"10.1016\u002Fj.ccr.2013.02.013",{"id":3028,"createTime":3029,"updateTime":3029,"relativeEntities":3030,"slug":3031,"properties":3032,"entityType":854,"verifyStatus":25,"verifyTime":3029,"verifyNote":855,"syncStatus":28,"languages":3045,"translateLanguages":26,"viewCount":36,"primaryUrl":3046,"fullTextUrl":26,"authors":3047,"publicationType":918,"publisherRelationship":3175,"citationCount":3212,"citationInfo":3213,"publishDate":3225,"publishYear":3226,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":3227,"isForceReanalyzing":1501},"dae5b648-63e1-4b25-a213-582d834d861f","2024-10-04T16:53:12.279+00:00",[],"Neurogenesis-in-the-adult-human-hippocampus",{"mag":3033,"keywords":3035,"openalex":3036,"abstract":3038,"title":3039,"pm":3041,"doi":3043},{"VOID":3034},"2067856703",{},{"VOID":3037},"W2067856703",{},{"EN":3040},"Neurogenesis in the adult human hippocampus",{"VOID":3042},"9809557",{"VOID":3044},"10.1038\u002F3305",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm1198_1313",[3048,3069,3090,3107,3126,3145,3160],{"id":3049,"sortIndex":114,"researcher":26,"roles":3050,"affiliations":3051,"properties":3062},"c4a5fb08-a1d6-42c4-a2a2-346dba1ad444",[],[3052],{"id":3053,"sortIndex":36,"affiliation":3054,"properties":26},"1412e1c4-e476-4c5f-95c1-428dd2f8728a",{"id":3055,"createTime":3056,"updateTime":3056,"relativeEntities":3057,"slug":3058,"properties":3059,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"5da51f6f-1f8d-4b0a-a923-005e35f28a49","2024-10-04T16:53:12.316+00:00",[],"Department-of-Clinical-Neuroscience-Department-of-Oncology-Sahlgrenska-University-Hospital-G%C3%B6teborg-41345-Sweden",{"title":3060},{"EN":3061},"Department of Clinical Neuroscience, Department of Oncology, Sahlgrenska University Hospital, Göteborg, 41345, Sweden",{"openalex":3063,"orcid":3065,"title":3067},{"VOID":3064},"A5067177483",{"VOID":3066},"https:\u002F\u002Forcid.org\u002F0000-0003-3680-5196",{"EN":3068},"Thomas Björk‐Eriksson",{"id":3070,"sortIndex":135,"researcher":26,"roles":3071,"affiliations":3072,"properties":3083},"63cdae54-62c1-459f-ad32-4ec277bd259b",[],[3073],{"id":3074,"sortIndex":36,"affiliation":3075,"properties":26},"1ab4efdd-16af-433f-ab50-9a69b9d75418",{"id":3076,"createTime":3077,"updateTime":3077,"relativeEntities":3078,"slug":3079,"properties":3080,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"3250af6f-f842-4eb6-a180-0922c998d697","2024-10-04T16:53:12.347+00:00",[],"Laboratory-of-Genetics-The-Salk-Institute-for-Biological-Studies-10010-North-Torrey-Pines-Road-La-Jolla-92037-California-USA",{"title":3081},{"EN":3082},"Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, 92037, California, USA",{"openalex":3084,"orcid":3086,"title":3088},{"VOID":3085},"A5072968010",{"VOID":3087},"https:\u002F\u002Forcid.org\u002F0000-0002-0938-4106",{"EN":3089},"Fred H. Gage",{"id":3091,"sortIndex":162,"researcher":26,"roles":3092,"affiliations":3093,"properties":3100},"913a7021-ccad-47ee-842e-c793aceaa3cf",[],[3094],{"id":3095,"sortIndex":36,"affiliation":3096,"properties":26},"59179be3-89e9-47d4-a463-f5bb48087e54",{"id":3076,"createTime":3077,"updateTime":3077,"relativeEntities":3097,"slug":3079,"properties":3098,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3099},{"EN":3082},{"openalex":3101,"orcid":3103,"title":3105},{"VOID":3102},"A5028337949",{"VOID":3104},"https:\u002F\u002Forcid.org\u002F0000-0001-7275-6403",{"EN":3106},"Daniel A. Peterson",{"id":3108,"sortIndex":111,"researcher":26,"roles":3109,"affiliations":3110,"properties":3121},"120591dc-731a-45c1-ab89-a01bee211508",[],[3111],{"id":3112,"sortIndex":36,"affiliation":3113,"properties":26},"87cc03e2-21ab-4a3a-ac03-34f8b90e949e",{"id":3114,"createTime":3115,"updateTime":3115,"relativeEntities":3116,"slug":3117,"properties":3118,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"ecbdf95d-3418-42b3-ad8c-53a74f74c4d8","2024-10-04T16:53:12.336+00:00",[],"Department-of-Clinical-Neuroscience-Department-of-Pathology-Sahlgrenska-University-Hospital-G%C3%B6teborg-41345-Sweden",{"title":3119},{"EN":3120},"Department of Clinical Neuroscience, Department of Pathology, Sahlgrenska University Hospital, Göteborg, 41345, Sweden",{"openalex":3122,"title":3124},{"VOID":3123},"A5026686163",{"EN":3125},"Claes Nordborg",{"id":3127,"sortIndex":59,"researcher":26,"roles":3128,"affiliations":3129,"properties":3140},"e3ecb649-2838-48ca-9f78-8d847e02504a",[],[3130],{"id":3131,"sortIndex":36,"affiliation":3132,"properties":26},"222e9d9b-0a3f-4802-a8a5-ab3f44c549cb",{"id":3133,"createTime":3134,"updateTime":3134,"relativeEntities":3135,"slug":3136,"properties":3137,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e32329b1-78dd-4231-965c-a3b14a0e3df5","2024-10-04T16:53:12.297+00:00",[],"Department-of-Clinical-Neuroscience-Institute-of-Neurology-Sahlgrenska-University-Hospital-G%C3%B6teborg-41345-Sweden",{"title":3138},{"EN":3139},"Department of Clinical Neuroscience, Institute of Neurology Sahlgrenska University Hospital, Göteborg, 41345, Sweden",{"openalex":3141,"title":3143},{"VOID":3142},"A5018163652",{"EN":3144},"Ann-Marie Alborn",{"id":3146,"sortIndex":115,"researcher":26,"roles":3147,"affiliations":3148,"properties":3155},"2628708b-69fb-4212-b8fc-8f47f02207b0",[],[3149],{"id":3150,"sortIndex":36,"affiliation":3151,"properties":26},"e8cb7367-f23d-406d-a54e-dfcad989636f",{"id":3133,"createTime":3134,"updateTime":3134,"relativeEntities":3152,"slug":3136,"properties":3153,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3154},{"EN":3139},{"openalex":3156,"title":3158},{"VOID":3157},"A5081287638",{"EN":3159},"Ekaterina Perfilieva",{"id":3161,"sortIndex":36,"researcher":26,"roles":3162,"affiliations":3163,"properties":3170},"bca31295-ca47-4bba-8549-fdd658e19765",[],[3164],{"id":3165,"sortIndex":36,"affiliation":3166,"properties":26},"ed67dcac-0e90-45dd-ac81-0695e44f1a55",{"id":3133,"createTime":3134,"updateTime":3134,"relativeEntities":3167,"slug":3136,"properties":3168,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3169},{"EN":3139},{"openalex":3171,"title":3173},{"VOID":3172},"A5065124171",{"EN":3174},"Peter S. Eriksson",{"url":26,"publisher":3176,"properties":3206},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3177,"slug":663,"properties":3178,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3184,"manageAffiliations":3185,"indexDatabases":3186,"url":755,"thumbnailPath":26,"statistic":3201,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":3179,"issn":3180,"introduce":3181,"eissn":3182,"title":3183},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[3187,3194],{"id":736,"indexDatabase":3188,"url":749,"indexYears":750,"academicFieldIds":3193,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":3189,"label":3190,"description":3191,"key":746,"publicationTags":3192,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":3195,"url":730,"indexYears":26,"academicFieldIds":3200,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":3196,"label":3197,"description":3198,"key":726,"publicationTags":3199,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":3202,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":3203,"totalCitation":772,"totalCitationByYear":3204,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":3205,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":3207,"pages":3209,"issue":3211},{"VOID":3208},"4",{"VOID":3210},"1313-1317",{"VOID":2223},6143,{"total":3212,"publishYear":26,"statisticByYear":3214},{"2012":3215,"2013":3216,"2014":3217,"2015":3218,"2016":3219,"2017":3220,"2018":3221,"2019":769,"2020":3222,"2021":3223,"2022":1588,"2023":1590,"2024":3224},288,304,342,294,302,258,263,230,231,110,"1998-11-01",1998,[3228,3232,3236,3240,3244,3248,3252,3256,3260,3263,3267,3271,3275,3279,3283,3287,3291,3295,3299,3303,3307,3311,3315,3319,3323,3327,3331],{"id":26,"text":3229,"url":26,"identifiers":3230},"Altman, J. &. Das, G.D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. &gt;J. Comp. Neurol. 124, 319–335 ( 1965).",{"doi":3231},"10.1002\u002Fcne.901240303",{"id":26,"text":3233,"url":26,"identifiers":3234},"Altman, J. & Das, G.D. Postnatal neurogenesis in the guinea-pig. Nature 214, 1098–1101 (1967).",{"doi":3235},"10.1038\u002F2141098a0",{"id":26,"text":3237,"url":26,"identifiers":3238},"Caviness, V.S. Time of neuron origin in the hippocampus and dentate gyrus of normal and reeler mutant mice: an autoradiographic analysis. J. Comp. Neurol. 151, 113–120 (1973).",{"doi":3239},"10.1002\u002Fcne.901510203",{"id":26,"text":3241,"url":26,"identifiers":3242},"Gueneau, G., Privat, A., Drouet, J. & Court, L. Subgranular zone of the dentate gyrus of young rabbits as a secondary matrix. A high-resolution autoradiographic study. Dev. Neurosci. 5, 345–358 (1982).",{"doi":3243},"10.1159\u002F000112694",{"id":26,"text":3245,"url":26,"identifiers":3246},"Kuhn, H.G., Dickinson-Anson, H. & Gage, F.H. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027–2033 ( 1996).",{"doi":3247},"10.1523\u002FJNEUROSCI.16-06-02027.1996",{"id":26,"text":3249,"url":26,"identifiers":3250},"Gould, E., Tanapat, P., McEwen, B.S., Flugge, G. & Fuchs, E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl. Acad. Sci. USA 95, 3168– 3171 (1998).",{"doi":3251},"10.1073\u002Fpnas.95.6.3168",{"id":26,"text":3253,"url":26,"identifiers":3254},"Kaplan, M.S. & Bell, D.H. Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus. J. Neurosci. 4 , 1429–1441 (1984).",{"doi":3255},"10.1523\u002FJNEUROSCI.04-06-01429.1984",{"id":26,"text":3257,"url":26,"identifiers":3258},"Kaplan, M.S. & Hinds, J.W. Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 197, 1092–1094 (1977).",{"doi":3259},"10.1126\u002Fscience.887941",{"id":26,"text":3261,"url":26,"identifiers":3262},"Stanfield, B.B. & Trice, J.E. Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections. Exp. Brain Res. 72, 399– 406 (1988).",{},{"id":26,"text":3264,"url":26,"identifiers":3265},"Cameron, H.A., Woolley, C.S., McEwen, B.S. & Gould, E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 56, 337– 344 (1993).",{"doi":3266},"10.1016\u002F0306-4522(93)90335-D",{"id":26,"text":3268,"url":26,"identifiers":3269},"Dolbeare, F. Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part I: Historical perspectives, histochemical methods and cell kinetics. Histochem. J. 27, 339–369 ( 1995).",{"doi":3270},"10.1007\u002FBF02389022",{"id":26,"text":3272,"url":26,"identifiers":3273},"Kempermann, G., Kuhn, H.G. & Gage, F.H. Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc. Natl. Acad. Sci. USA 94, 10409–10414 (1997).",{"doi":3274},"10.1073\u002Fpnas.94.19.10409",{"id":26,"text":3276,"url":26,"identifiers":3277},"del Rio, J.A. & Soriano, E. Immunocytochemical detection of 5'-bromodeoxyuridine incorporation in the central nervous system of the mouse. Dev. Brain Res. 49, 311– 317 (1989).",{"doi":3278},"10.1016\u002F0165-3806(89)90033-3",{"id":26,"text":3280,"url":26,"identifiers":3281},"Gundersen, H.J. et al. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96, 857–881 (1988).",{"doi":3282},"10.1111\u002Fj.1699-0463.1988.tb00954.x",{"id":26,"text":3284,"url":26,"identifiers":3285},"West, M.J. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging 14, 287–293 (1993).",{"doi":3286},"10.1016\u002F0197-4580(93)90113-P",{"id":26,"text":3288,"url":26,"identifiers":3289},"Coggeshall, R.E. & Lekan, H.A. Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J. Comp. Neurol. 364, 6– 15 (1996).",{"doi":3290},"10.1002\u002F(SICI)1096-9861(19960101)364:1\u003C6::AID-CNE2>3.0.CO;2-9",{"id":26,"text":3292,"url":26,"identifiers":3293},"Kempermann, G., Kuhn, H.G. & Gage, F.H. More hippocampal neurons in adult mice living in an enriched environmen Nature 386, 493– 495 (1997).",{"doi":3294},"10.1038\u002F386493a0",{"id":26,"text":3296,"url":26,"identifiers":3297},"Mullen, R.J., Buck, C.R. & Smith, A.M. NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201–211 (1992).",{"doi":3298},"10.1242\u002Fdev.116.1.201",{"id":26,"text":3300,"url":26,"identifiers":3301},"Wolf, H.K. et al. NeuN: A useful neuronal marker for diagnostic histopathology. J. Histochem. Cytochem. 44, 1167– 1171 (1996).",{"doi":3302},"10.1177\u002F44.10.8813082",{"id":26,"text":3304,"url":26,"identifiers":3305},"Sloviter, R.S. Calcium-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity. J. Comp. Neurol. 280, 183–196 ( 1989).",{"doi":3306},"10.1002\u002Fcne.902800203",{"id":26,"text":3308,"url":26,"identifiers":3309},"Schmechel, D., Marango, P.J., Zis, A.P., Brightman, M. & Goodwin, F.K. Brain enolases as specific markers of neuronal and glial cells. Science 199, 313– 315 (1978).",{"doi":3310},"10.1126\u002Fscience.339349",{"id":26,"text":3312,"url":26,"identifiers":3313},"Kirschenbaum, B. et al. In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cereb. Cortex 4, 576–589 ( 1994).",{"doi":3314},"10.1093\u002Fcercor\u002F4.6.576",{"id":26,"text":3316,"url":26,"identifiers":3317},"Rakic, P. Limits of neurogenesis in primates. Science 227, 1054–1056 (1985).",{"doi":3318},"10.1126\u002Fscience.3975601",{"id":26,"text":3320,"url":26,"identifiers":3321},"Eckenhoff M.F. & Rakic, P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. J. Neurosci. 8, 2729 –2747 (1988).",{"doi":3322},"10.1523\u002FJNEUROSCI.08-08-02729.1988",{"id":26,"text":3324,"url":26,"identifiers":3325},"Kempermann, G., Kuhn, H.G. & Gage, F.H. Experience-induced neurogenesis in the senescent dentate gyrus. J. Neurosci. 18, 3206– 3212 (1998).",{"doi":3326},"10.1523\u002FJNEUROSCI.18-09-03206.1998",{"id":26,"text":3328,"url":26,"identifiers":3329},"Gage, F.H. et al. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc. Natl. Acad. Sci. USA 92, 11879–11883 ( 1995).",{"doi":3330},"10.1073\u002Fpnas.92.25.11879",{"id":26,"text":3332,"url":26,"identifiers":3333},"Suhonen, J.O., Peterson, D.A., Ray, J. & Gage, F.H. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 383, 624–627 ( 1996).",{"doi":3334},"10.1038\u002F383624a0",{"id":3336,"createTime":3337,"updateTime":3337,"relativeEntities":3338,"slug":3339,"properties":3340,"entityType":854,"verifyStatus":25,"verifyTime":3355,"verifyNote":855,"syncStatus":28,"languages":3356,"translateLanguages":26,"viewCount":36,"primaryUrl":3357,"fullTextUrl":26,"authors":3358,"publicationType":918,"publisherRelationship":3467,"citationCount":3504,"citationInfo":3505,"publishDate":3512,"publishYear":3513,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":3514,"isForceReanalyzing":1501},"c3443e10-b344-4a0a-918a-42f17f06d3eb","2024-09-21T18:47:30.049+00:00",[],"The-proximal-origin-of-SARS-CoV-2",{"mag":3341,"keywords":3343,"pmc":3344,"openalex":3346,"abstract":3348,"title":3349,"pm":3351,"doi":3353},{"VOID":3342},"3011127849",{},{"VOID":3345},"7095063",{"VOID":3347},"W3011127849",{},{"EN":3350},"The proximal origin of SARS-CoV-2",{"VOID":3352},"32284615",{"VOID":3354},"10.1038\u002Fs41591-020-0820-9","2024-09-21T18:47:30.048+00:00",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41591-020-0820-9",[3359,3381,3402,3424,3445],{"id":3360,"sortIndex":59,"researcher":26,"roles":3361,"affiliations":3362,"properties":3374},"a0437e3e-7bfa-4bc3-aad3-7be435a2e5b0",[],[3363],{"id":3364,"sortIndex":36,"affiliation":3365,"properties":26},"eccfd75c-2038-4515-887f-64e5ee66ce22",{"id":3366,"createTime":3367,"updateTime":3368,"relativeEntities":3369,"slug":3370,"properties":3371,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d22ae99e-d373-4d9d-8d3a-a84ae6dc7cac","2024-01-04T23:26:23.914+00:00","2024-09-21T18:47:30.118+00:00",[],"Marie-Bashir-Institute-for-Infectious-Diseases-and-Biosecurity-School-of-Life-and-Environmental-Sciences-and-School-of-Medical-Sciences-The-University-of-Sydney-Sydney-Australia",{"title":3372},{"VI":3373},"Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, Australia",{"openalex":3375,"orcid":3377,"title":3379},{"VOID":3376},"A5085736091",{"VOID":3378},"https:\u002F\u002Forcid.org\u002F0000-0001-9596-3552",{"EN":3380},"Edward C. Holmes",{"id":3382,"sortIndex":114,"researcher":26,"roles":3383,"affiliations":3384,"properties":3395},"f5d3f943-0c26-45f2-b5af-d7338aa8eea9",[],[3385],{"id":3386,"sortIndex":36,"affiliation":3387,"properties":26},"ab3299bf-c1c1-48a0-95ea-4a1d115fc615",{"id":3388,"createTime":3389,"updateTime":3389,"relativeEntities":3390,"slug":3391,"properties":3392,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"6ad48843-8ac1-48fe-9664-caeb8852e9f0","2024-09-21T18:47:30.100+00:00",[],"Center-for-Infection-and-Immunity-Mailman-School-of-Public-Health-of-Columbia-University-New-York-NY-USA",{"title":3393},{"EN":3394},"Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, NY, USA",{"openalex":3396,"orcid":3398,"title":3400},{"VOID":3397},"A5090343848",{"VOID":3399},"https:\u002F\u002Forcid.org\u002F0000-0002-8768-9386",{"EN":3401},"W. Ian Lipkin",{"id":3403,"sortIndex":115,"researcher":26,"roles":3404,"affiliations":3405,"properties":3417},"f40fcc0e-80c0-4799-98ad-b3886921a047",[],[3406],{"id":3407,"sortIndex":36,"affiliation":3408,"properties":26},"e6c1a698-b18d-4a41-a0ae-240bf3caf62b",{"id":3409,"createTime":3410,"updateTime":3411,"relativeEntities":3412,"slug":3413,"properties":3414,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"4ee7d35b-c508-48cf-ab74-f1cfc0aaad66","2024-02-10T21:28:56.869+00:00","2024-12-03T13:30:38.255+00:00",[],"Institute-of-Evolutionary-Biology-University-of-Edinburgh-Edinburgh-UK",{"title":3415},{"VI":3416},"Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK",{"openalex":3418,"orcid":3420,"title":3422},{"VOID":3419},"A5083534383",{"VOID":3421},"https:\u002F\u002Forcid.org\u002F0000-0003-4337-3707",{"EN":3423},"Andrew Rambaut",{"id":3425,"sortIndex":111,"researcher":26,"roles":3426,"affiliations":3427,"properties":3438},"84d3718b-0bf0-4e42-8599-60d852a4e911",[],[3428],{"id":3429,"sortIndex":36,"affiliation":3430,"properties":26},"4d525fef-ddc4-416c-aa17-7ea1fe8780b6",{"id":3431,"createTime":3432,"updateTime":3432,"relativeEntities":3433,"slug":3434,"properties":3435,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"3f8f966b-4b93-4672-95e8-eef51ab462c2","2024-09-21T18:47:30.134+00:00",[],"Tulane-University-School-of-Medicine-Department-of-Microbiology-and-Immunology-New-Orleans-LA-USA",{"title":3436},{"EN":3437},"Tulane University, School of Medicine, Department of Microbiology and Immunology, New Orleans, LA, USA",{"openalex":3439,"orcid":3441,"title":3443},{"VOID":3440},"A5016090653",{"VOID":3442},"https:\u002F\u002Forcid.org\u002F0000-0002-5683-3250",{"EN":3444},"Robert F. Garry",{"id":3446,"sortIndex":36,"researcher":26,"roles":3447,"affiliations":3448,"properties":3460},"3cde965e-4fa6-4587-a520-8babea7056d4",[],[3449],{"id":3450,"sortIndex":36,"affiliation":3451,"properties":26},"50766c6b-9ad4-4a8d-81de-15e0f881fb77",{"id":3452,"createTime":3453,"updateTime":3454,"relativeEntities":3455,"slug":3456,"properties":3457,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b6b9e515-fd56-4f9c-803d-137b5731cd4f","2023-12-27T12:04:06.022+00:00","2024-09-21T18:47:30.069+00:00",[],"Department-of-Immunology-and-Microbiology-The-Scripps-Research-Institute-La-Jolla-CA-USA",{"title":3458},{"VI":3459},"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA",{"openalex":3461,"orcid":3463,"title":3465},{"VOID":3462},"A5028103881",{"VOID":3464},"https:\u002F\u002Forcid.org\u002F0000-0001-6431-5982",{"EN":3466},"Kristian G. Andersen",{"url":26,"publisher":3468,"properties":3498},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":3469,"slug":663,"properties":3470,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":3476,"manageAffiliations":3477,"indexDatabases":3478,"url":755,"thumbnailPath":26,"statistic":3493,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":3471,"issn":3472,"introduce":3473,"eissn":3474,"title":3475},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[3479,3486],{"id":736,"indexDatabase":3480,"url":749,"indexYears":750,"academicFieldIds":3485,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":3481,"label":3482,"description":3483,"key":746,"publicationTags":3484,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":3487,"url":730,"indexYears":26,"academicFieldIds":3492,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":3488,"label":3489,"description":3490,"key":726,"publicationTags":3491,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":3494,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":3495,"totalCitation":772,"totalCitationByYear":3496,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":3497,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":3499,"pages":3501,"issue":3503},{"VOID":3500},"26",{"VOID":3502},"450-452",{"VOID":3208},5076,{"total":3504,"publishYear":26,"statisticByYear":3506},{"2012":115,"2017":115,"2019":115,"2020":3507,"2021":3508,"2022":3509,"2023":3510,"2024":3511},1855,1590,909,414,178,"2020-04-01",2020,[3515,3519,3523,3527,3531,3535,3539,3543,3547,3551,3555,3559,3563,3567,3571,3575,3579,3583,3587,3591,3595,3599,3603,3606,3610,3614,3618,3622,3626,3630],{"id":26,"text":3516,"url":26,"identifiers":3517},"Zhou, P. et al. Nature https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41586-020-2012-7 (2020).",{"doi":3518},"10.1038\u002Fs41586-020-2012-7",{"id":26,"text":3520,"url":26,"identifiers":3521},"Wu, F. et al. Nature https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41586-020-2008-3 (2020).",{"doi":3522},"10.1038\u002Fs41586-020-2008-3",{"id":26,"text":3524,"url":26,"identifiers":3525},"Gorbalenya, A. E. et al. bioRxiv https:\u002F\u002Fdoi.org\u002F10.1101\u002F2020.02.07.937862 (2020).",{"doi":3526},"10.1101\u002F2020.02.07.937862",{"id":26,"text":3528,"url":26,"identifiers":3529},"Jiang, S. et al. Lancet https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(20)30419-0 (2020).",{"doi":3530},"10.1016\u002FS0140-6736(20)30419-0",{"id":26,"text":3532,"url":26,"identifiers":3533},"Dong, E., Du, H. & Gardner, L. Lancet Infect. Dis. https:\u002F\u002Fdoi.org\u002F10.1016\u002FS1473-3099(20)30120-1 (2020).",{"doi":3534},"10.1016\u002FS1473-3099(20)30120-1",{"id":26,"text":3536,"url":26,"identifiers":3537},"Corman, V. M., Muth, D., Niemeyer, D. & Drosten, C. Adv. Virus Res. 100, 163–188 (2018).",{"doi":3538},"10.1016\u002Fbs.aivir.2018.01.001",{"id":26,"text":3540,"url":26,"identifiers":3541},"Wan, Y., Shang, J., Graham, R., Baric, R. S. & Li, F. J. Virol. https:\u002F\u002Fdoi.org\u002F10.1128\u002FJVI.00127-20 (2020).",{"doi":3542},"10.1128\u002FJVI.00127-20",{"id":26,"text":3544,"url":26,"identifiers":3545},"Walls, A. C. et al. bioRxiv https:\u002F\u002Fdoi.org\u002F10.1101\u002F2020.02.19.956581 (2020).",{"doi":3546},"10.1101\u002F2020.02.19.956581",{"id":26,"text":3548,"url":26,"identifiers":3549},"Wrapp, D. et al. Science https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.abb2507 (2020).",{"doi":3550},"10.1126\u002Fscience.abb2507",{"id":26,"text":3552,"url":26,"identifiers":3553},"Letko, M., Marzi, A. & Munster, V. Nat. Microbiol. https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41564-020-0688-y (2020).",{"doi":3554},"10.1038\u002Fs41564-020-0688-y",{"id":26,"text":3556,"url":26,"identifiers":3557},"Sheahan, T. et al. J. Virol. 82, 2274–2285 (2008).",{"doi":3558},"10.1128\u002FJVI.02041-07",{"id":26,"text":3560,"url":26,"identifiers":3561},"Nao, N. et al. MBio 8, e02298-16 (2017).",{"doi":3562},"10.1128\u002FmBio.02298-16",{"id":26,"text":3564,"url":26,"identifiers":3565},"Chan, C.-M. et al. Exp. Biol. Med. 233, 1527–1536 (2008).",{"doi":3566},"10.3181\u002F0806-RM-197",{"id":26,"text":3568,"url":26,"identifiers":3569},"Follis, K. E., York, J. & Nunberg, J. H. Virology 350, 358–369 (2006).",{"doi":3570},"10.1016\u002Fj.virol.2006.02.003",{"id":26,"text":3572,"url":26,"identifiers":3573},"Menachery, V. D. et al. J. Virol. https:\u002F\u002Fdoi.org\u002F10.1128\u002FJVI.01774-19 (2019).",{"doi":3574},"10.1128\u002FJVI.01774-19",{"id":26,"text":3576,"url":26,"identifiers":3577},"Alexander, D. J. & Brown, I. H. Rev. Sci. Tech. 28, 19–38 (2009).",{"doi":3578},"10.20506\u002Frst.28.1.1856",{"id":26,"text":3580,"url":26,"identifiers":3581},"Ito, T. et al. J. Virol. 75, 4439–4443 (2001).",{"doi":3582},"10.1128\u002FJVI.75.9.4439-4443.2001",{"id":26,"text":3584,"url":26,"identifiers":3585},"Bagdonaite, I. & Wandall, H. H. Glycobiology 28, 443–467 (2018).",{"doi":3586},"10.1093\u002Fglycob\u002Fcwy021",{"id":26,"text":3588,"url":26,"identifiers":3589},"Cui, J., Li, F. & Shi, Z.-L. Nat. Rev. Microbiol. 17, 181–192 (2019).",{"doi":3590},"10.1038\u002Fs41579-018-0118-9",{"id":26,"text":3592,"url":26,"identifiers":3593},"Almazán, F. et al. Virus Res. 189, 262–270 (2014).",{"doi":3594},"10.1016\u002Fj.virusres.2014.05.026",{"id":26,"text":3596,"url":26,"identifiers":3597},"Zhang, T., Wu, Q. & Zhang, Z. bioRxiv https:\u002F\u002Fdoi.org\u002F10.1101\u002F2020.02.19.950253 (2020).",{"doi":3598},"10.1101\u002F2020.02.19.950253",{"id":26,"text":3600,"url":26,"identifiers":3601},"Yamada, Y. & Liu, D. X. J. Virol. 83, 8744–8758 (2009).",{"doi":3602},"10.1128\u002FJVI.00613-09",{"id":26,"text":3604,"url":26,"identifiers":3605},"Rambaut, A. Virological.org http:\u002F\u002Fvirological.org\u002Ft\u002F356 (2020).",{},{"id":26,"text":3607,"url":26,"identifiers":3608},"Huang, C. et al. Lancet https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140-6736(20)30183-5 (2020).",{"doi":3609},"10.1016\u002FS0140-6736(20)30183-5",{"id":26,"text":3611,"url":26,"identifiers":3612},"Dudas, G., Carvalho, L. M., Rambaut, A. & Bedford, T. eLife 7, e31257 (2018).",{"doi":3613},"10.7554\u002FeLife.31257",{"id":26,"text":3615,"url":26,"identifiers":3616},"Wang, N. et al. Virol. Sin. 33, 104–107 (2018).",{"doi":3617},"10.1007\u002Fs12250-018-0012-7",{"id":26,"text":3619,"url":26,"identifiers":3620},"Ge, X.-Y. et al. Nature 503, 535–538 (2013).",{"doi":3621},"10.1038\u002Fnature12711",{"id":26,"text":3623,"url":26,"identifiers":3624},"Lim, P. L. et al. N. Engl. J. Med. 350, 1740–1745 (2004).",{"doi":3625},"10.1056\u002FNEJMoa032565",{"id":26,"text":3627,"url":26,"identifiers":3628},"Wong, M. C., Javornik Cregeen, S. J., Ajami, N. J. & Petrosino, J. F. bioRxiv https:\u002F\u002Fdoi.org\u002F10.1101\u002F2020.02.07.939207 (2020).",{"doi":3629},"10.1101\u002F2020.02.07.939207",{"id":26,"text":3631,"url":26,"identifiers":3632},"Liu, P., Chen, W. & Chen, J.-P. Viruses 11, 979 (2019).",{"doi":3633},"10.3390\u002Fv11110979",{"id":3635,"createTime":3636,"updateTime":3636,"relativeEntities":3637,"slug":3638,"properties":3639,"entityType":854,"verifyStatus":25,"verifyTime":3652,"verifyNote":855,"syncStatus":28,"languages":3653,"translateLanguages":26,"viewCount":36,"primaryUrl":3654,"fullTextUrl":26,"authors":3655,"publicationType":918,"publisherRelationship":4108,"citationCount":4145,"citationInfo":4146,"publishDate":4154,"publishYear":4155,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":4156,"isForceReanalyzing":1501},"3e09263c-d584-40c6-a0ec-95cb62d494e3","2024-09-19T00:28:39.114+00:00",[],"The-fat-derived-hormone-adiponectin-reverses-insulin-resistance-associated-with-both-lipoatrophy-and-obesity",{"mag":3640,"keywords":3642,"openalex":3643,"abstract":3645,"title":3646,"pm":3648,"doi":3650},{"VOID":3641},"1587875569",{},{"VOID":3644},"W1587875569",{},{"EN":3647},"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity",{"VOID":3649},"11479627",{"VOID":3651},"10.1038\u002F90984","2024-09-19T00:28:39.113+00:00",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm0801_941",[3656,3676,3696,3716,3733,3750,3771,3791,3808,3823,3840,3857,3877,3899,3916,3933,3954,3969,3986,4003,4020,4037,4059,4076,4093],{"id":3657,"sortIndex":356,"researcher":26,"roles":3658,"affiliations":3659,"properties":3671},"c8108b70-1dbd-4129-abd3-174afc48a910",[],[3660],{"id":3661,"sortIndex":36,"affiliation":3662,"properties":26},"bf9ec413-bd91-4621-bbbb-e15c4fd177fa",{"id":3663,"createTime":3664,"updateTime":3665,"relativeEntities":3666,"slug":3667,"properties":3668,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"67de1523-a19a-4a39-9a0c-0887094117c5","2023-12-28T13:06:22.303+00:00","2024-09-19T00:28:39.435+00:00",[],"Laboratory-of-Metabolism-National-Cancer-Institute-National-Institutes-of-Health-Bethesda-USA",{"title":3669},{"VI":3670},"Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, USA",{"openalex":3672,"title":3674},{"VOID":3673},"A5069670729",{"EN":3675},"Charles Vinson",{"id":3677,"sortIndex":336,"researcher":26,"roles":3678,"affiliations":3679,"properties":3691},"e253bed6-a091-4dd9-a698-34c0cd3b79c8",[],[3680],{"id":3681,"sortIndex":36,"affiliation":3682,"properties":26},"f4a99a60-e48c-49fc-9efd-b536addfab5e",{"id":3683,"createTime":3684,"updateTime":3685,"relativeEntities":3686,"slug":3687,"properties":3688,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"b4aaed9c-9a23-468d-b54a-510182682d15","2023-12-29T16:00:02.455+00:00","2024-09-19T00:28:39.196+00:00",[],"Graduate-School-of-Pharmaceutical-Sciences-University-of-Tokyo-Tokyo-Japan",{"title":3689},{"VI":3690},"Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan",{"openalex":3692,"title":3694},{"VOID":3693},"A5027083732",{"EN":3695},"Koichi Shudo",{"id":3697,"sortIndex":115,"researcher":26,"roles":3698,"affiliations":3699,"properties":3711},"36b19c39-b320-464f-b37c-a6778951a2fd",[],[3700],{"id":3701,"sortIndex":36,"affiliation":3702,"properties":26},"c32dcf55-72c2-410e-b3ea-0bbae7e0dd0b",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3706,"slug":3707,"properties":3708,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"9e375521-363b-47bc-bd80-103a41ce5286","2024-01-13T15:42:11.932+00:00","2025-01-31T06:59:17.043+00:00",[],"Department-of-Internal-Medicine-Graduate-School-of-Medicine-University-of-Tokyo-Tokyo-Japan",{"title":3709},{"VI":3710},"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan",{"openalex":3712,"title":3714},{"VOID":3713},"A5053784133",{"EN":3715},"Junji Kamon",{"id":3717,"sortIndex":234,"researcher":26,"roles":3718,"affiliations":3719,"properties":3726},"5da73140-75bf-468e-8270-a29a1ad5429b",[],[3720],{"id":3721,"sortIndex":36,"affiliation":3722,"properties":26},"b348a186-1f4d-42aa-a70b-e6ead32e9f76",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3723,"slug":3707,"properties":3724,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3725},{"VI":3710},{"openalex":3727,"orcid":3729,"title":3731},{"VOID":3728},"A5070737875",{"VOID":3730},"https:\u002F\u002Forcid.org\u002F0000-0003-0015-0255",{"EN":3732},"Kazuyuki Tobe",{"id":3734,"sortIndex":238,"researcher":26,"roles":3735,"affiliations":3736,"properties":3743},"803b8cd2-424a-4689-924a-2d508e221097",[],[3737],{"id":3738,"sortIndex":36,"affiliation":3739,"properties":26},"adb0ae1a-ba73-4457-ad2b-42f1a2a95f28",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3740,"slug":3707,"properties":3741,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3742},{"VI":3710},{"openalex":3744,"orcid":3746,"title":3748},{"VOID":3745},"A5040548657",{"VOID":3747},"https:\u002F\u002Forcid.org\u002F0000-0002-5428-3582",{"EN":3749},"Takashi Kadowaki",{"id":3751,"sortIndex":237,"researcher":26,"roles":3752,"affiliations":3753,"properties":3764},"84f7e957-ef2f-4b57-804a-8e922ba5c260",[],[3754],{"id":3755,"sortIndex":36,"affiliation":3756,"properties":26},"2808bf1e-03f2-4e52-9cc1-8fbbdd55caa1",{"id":3757,"createTime":3758,"updateTime":3758,"relativeEntities":3759,"slug":3760,"properties":3761,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"5dafe82f-2446-4037-9b36-38d0089377ad","2024-09-19T00:28:39.292+00:00",[],"Institute-of-Biology-CNRS-Pasteur-Institute-of-Lille-Lille-France",{"title":3762},{"EN":3763},"Institute of Biology-CNRS, Pasteur Institute of Lille, Lille, France",{"openalex":3765,"orcid":3767,"title":3769},{"VOID":3766},"A5009611870",{"VOID":3768},"https:\u002F\u002Forcid.org\u002F0000-0003-2972-0784",{"EN":3770},"Philippe Froguel",{"id":3772,"sortIndex":124,"researcher":26,"roles":3773,"affiliations":3774,"properties":3786},"156ffd53-cd1a-434e-aef1-bcaa1cb43de3",[],[3775],{"id":3776,"sortIndex":36,"affiliation":3777,"properties":26},"95708988-1fb2-4396-ae8b-a1c692025333",{"id":3778,"createTime":3779,"updateTime":3780,"relativeEntities":3781,"slug":3782,"properties":3783,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"6e76bc83-32a3-40a3-bce7-33e4fab42fd0","2024-01-14T17:21:38.201+00:00","2024-12-11T10:07:07.633+00:00",[],"Department-of-Physiological-Chemistry-School-of-Pharmaceutical-Sciences-Showa-University-Tokyo-Japan",{"title":3784},{"VI":3785},"Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo Japan",{"openalex":3787,"title":3789},{"VOID":3788},"A5017477923",{"EN":3790},"Madoka Yoda",{"id":3792,"sortIndex":516,"researcher":26,"roles":3793,"affiliations":3794,"properties":3801},"02248694-6678-46fb-932b-975f32407ddc",[],[3795],{"id":3796,"sortIndex":36,"affiliation":3797,"properties":26},"dd99173a-e896-4125-a706-f4618fbebc42",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3798,"slug":3707,"properties":3799,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3800},{"VI":3710},{"openalex":3802,"orcid":3804,"title":3806},{"VOID":3803},"A5056761543",{"VOID":3805},"https:\u002F\u002Forcid.org\u002F0000-0003-3555-5877",{"EN":3807},"Satoshi Kimura",{"id":3809,"sortIndex":239,"researcher":26,"roles":3810,"affiliations":3811,"properties":3818},"aae47139-9731-40b8-bb09-def2d4f45554",[],[3812],{"id":3813,"sortIndex":36,"affiliation":3814,"properties":26},"114be5a1-9156-4411-bea5-5e542ee910f0",{"id":3778,"createTime":3779,"updateTime":3780,"relativeEntities":3815,"slug":3782,"properties":3816,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3817},{"VI":3785},{"openalex":3819,"title":3821},{"VOID":3820},"A5046505815",{"EN":3822},"Motowo Tomita",{"id":3824,"sortIndex":173,"researcher":26,"roles":3825,"affiliations":3826,"properties":3833},"93c203c3-9b9b-4905-9772-641e68a7137d",[],[3827],{"id":3828,"sortIndex":36,"affiliation":3829,"properties":26},"6be9f4f9-8513-41fa-bfeb-898f049f5dfc",{"id":3778,"createTime":3779,"updateTime":3780,"relativeEntities":3830,"slug":3782,"properties":3831,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3832},{"VI":3785},{"openalex":3834,"orcid":3836,"title":3838},{"VOID":3835},"A5075184369",{"VOID":3837},"https:\u002F\u002Forcid.org\u002F0009-0004-0134-0565",{"EN":3839},"Yasuko Nakano",{"id":3841,"sortIndex":51,"researcher":26,"roles":3842,"affiliations":3843,"properties":3850},"030e21ac-a040-4359-ae68-0e8451f0c43d",[],[3844],{"id":3845,"sortIndex":36,"affiliation":3846,"properties":26},"95a5d556-a5d3-4a60-a004-2f6059b21c6d",{"id":3683,"createTime":3684,"updateTime":3685,"relativeEntities":3847,"slug":3687,"properties":3848,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3849},{"VI":3690},{"openalex":3851,"orcid":3853,"title":3855},{"VOID":3852},"A5033725334",{"VOID":3854},"https:\u002F\u002Forcid.org\u002F0000-0002-6747-1013",{"EN":3856},"Hiroyuki Kagechika",{"id":3858,"sortIndex":53,"researcher":26,"roles":3859,"affiliations":3860,"properties":3872},"281fd7d9-899f-4cfc-936c-5dc5b0a46a9b",[],[3861],{"id":3862,"sortIndex":36,"affiliation":3863,"properties":26},"47ed1231-396d-4149-8ed0-b71d7506cac7",{"id":3864,"createTime":3865,"updateTime":3866,"relativeEntities":3867,"slug":3868,"properties":3869,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"c27fa531-252f-424c-83f0-b9de893c4b7b","2024-01-22T06:30:13.163+00:00","2024-10-15T10:54:37.690+00:00",[],"Institute-for-Diabetes-Care-and-Research-Asahi-Life-Foundation-Tokyo-Japan",{"title":3870},{"VI":3871},"Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan",{"openalex":3873,"title":3875},{"VOID":3874},"A5039323844",{"EN":3876},"Yasuo Akanuma",{"id":3878,"sortIndex":50,"researcher":26,"roles":3879,"affiliations":3880,"properties":3892},"6b1561ac-297f-4eb0-9947-a0545b11c20b",[],[3881],{"id":3882,"sortIndex":36,"affiliation":3883,"properties":26},"c4dea787-29f5-4382-b979-f894baa38a43",{"id":3884,"createTime":3885,"updateTime":3886,"relativeEntities":3887,"slug":3888,"properties":3889,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"0a4eab47-929f-46eb-a9f0-3999fc7503b8","2024-01-13T11:21:36.276+00:00","2025-06-11T23:13:17.117+00:00",[],"Central-Research-Laboratories-Kyorin-Pharmaceutical-Tochigi-Japan",{"title":3890},{"VI":3891},"Central Research Laboratories, Kyorin Pharmaceutical, Tochigi, Japan",{"openalex":3893,"orcid":3895,"title":3897},{"VOID":3894},"A5030033498",{"VOID":3896},"https:\u002F\u002Forcid.org\u002F0000-0002-3745-4650",{"EN":3898},"Koji Murakami",{"id":3900,"sortIndex":36,"researcher":26,"roles":3901,"affiliations":3902,"properties":3909},"b8e72978-9699-47fd-9056-b881c648dafd",[],[3903],{"id":3904,"sortIndex":36,"affiliation":3905,"properties":26},"8e0ea273-c82b-4788-b882-070e34b48159",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3906,"slug":3707,"properties":3907,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3908},{"VI":3710},{"openalex":3910,"orcid":3912,"title":3914},{"VOID":3911},"A5029747116",{"VOID":3913},"https:\u002F\u002Forcid.org\u002F0000-0003-4827-6404",{"EN":3915},"Toshimasa Yamauchi",{"id":3917,"sortIndex":114,"researcher":26,"roles":3918,"affiliations":3919,"properties":3926},"ea75660d-da2a-4fd2-bedb-62bbdef0db0c",[],[3920],{"id":3921,"sortIndex":36,"affiliation":3922,"properties":26},"fd9f78a3-8dbe-4199-9028-368792680ada",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3923,"slug":3707,"properties":3924,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3925},{"VI":3710},{"openalex":3927,"orcid":3929,"title":3931},{"VOID":3928},"A5012452289",{"VOID":3930},"https:\u002F\u002Forcid.org\u002F0000-0002-5302-9793",{"EN":3932},"Hironori Waki",{"id":3934,"sortIndex":103,"researcher":26,"roles":3935,"affiliations":3936,"properties":3947},"291112e9-20cf-450e-9231-f4139458d8f3",[],[3937],{"id":3938,"sortIndex":36,"affiliation":3939,"properties":26},"365be5e9-8019-468c-82fd-b35f503170f5",{"id":3940,"createTime":3941,"updateTime":3941,"relativeEntities":3942,"slug":3943,"properties":3944,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"ed434ac4-625b-4fdd-9bb4-158e0158d6a8","2024-09-19T00:28:39.373+00:00",[],"Diabetes-Branch-National-Institute-of-Diabetes-Digestive-and-Kidney-Diseases-Bethesda-USA",{"title":3945},{"EN":3946},"Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, USA",{"openalex":3948,"orcid":3950,"title":3952},{"VOID":3949},"A5101557961",{"VOID":3951},"https:\u002F\u002Forcid.org\u002F0000-0002-9310-1198",{"EN":3953},"Oksana Gavrilova",{"id":3955,"sortIndex":158,"researcher":26,"roles":3956,"affiliations":3957,"properties":3964},"1d1812bb-76b5-4658-b300-4668e6d210a7",[],[3958],{"id":3959,"sortIndex":36,"affiliation":3960,"properties":26},"b3570f03-12f8-4f85-a6e1-fbf0336da4ca",{"id":3884,"createTime":3885,"updateTime":3886,"relativeEntities":3961,"slug":3888,"properties":3962,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3963},{"VI":3891},{"openalex":3965,"title":3967},{"VOID":3966},"A5081800948",{"EN":3968},"Tomohiro Ide",{"id":3970,"sortIndex":162,"researcher":26,"roles":3971,"affiliations":3972,"properties":3979},"e32c3325-a062-48e5-8229-7ee1d350003d",[],[3973],{"id":3974,"sortIndex":36,"affiliation":3975,"properties":26},"e47b723e-805b-4f75-9a68-2a6cc6056397",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3976,"slug":3707,"properties":3977,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3978},{"VI":3710},{"openalex":3980,"orcid":3982,"title":3984},{"VOID":3981},"A5048078824",{"VOID":3983},"https:\u002F\u002Forcid.org\u002F0000-0002-4699-6136",{"EN":3985},"Kazuo Hara",{"id":3987,"sortIndex":59,"researcher":26,"roles":3988,"affiliations":3989,"properties":3996},"55f6a910-7021-455b-8123-d9e104fd87f3",[],[3990],{"id":3991,"sortIndex":36,"affiliation":3992,"properties":26},"f0bbdf76-230b-4e7d-895a-25dabc16004a",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":3993,"slug":3707,"properties":3994,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":3995},{"VI":3710},{"openalex":3997,"orcid":3999,"title":4001},{"VOID":3998},"A5088387334",{"VOID":4000},"https:\u002F\u002Forcid.org\u002F0000-0002-8872-3697",{"EN":4002},"Yasuo Terauchi",{"id":4004,"sortIndex":135,"researcher":26,"roles":4005,"affiliations":4006,"properties":4013},"561a7e2e-8e3b-4479-b08a-a443af930f1d",[],[4007],{"id":4008,"sortIndex":36,"affiliation":4009,"properties":26},"b9de3c5e-3b5a-4554-8f7c-842ca536d283",{"id":3757,"createTime":3758,"updateTime":3758,"relativeEntities":4010,"slug":3760,"properties":4011,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4012},{"EN":3763},{"openalex":4014,"orcid":4016,"title":4018},{"VOID":4015},"A5084336392",{"VOID":4017},"https:\u002F\u002Forcid.org\u002F0000-0003-4836-7234",{"EN":4019},"Yoshihide Mori",{"id":4021,"sortIndex":298,"researcher":26,"roles":4022,"affiliations":4023,"properties":4030},"62bc9ba3-3f13-4118-999a-06ba169bc421",[],[4024],{"id":4025,"sortIndex":36,"affiliation":4026,"properties":26},"a8064b42-4e7c-410e-a9a1-9afa099ffe52",{"id":3940,"createTime":3941,"updateTime":3941,"relativeEntities":4027,"slug":3943,"properties":4028,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4029},{"EN":3946},{"openalex":4031,"orcid":4033,"title":4035},{"VOID":4032},"A5062031732",{"VOID":4034},"https:\u002F\u002Forcid.org\u002F0000-0002-0426-9475",{"EN":4036},"Marc L. Reitman",{"id":4038,"sortIndex":52,"researcher":26,"roles":4039,"affiliations":4040,"properties":4052},"22288b27-a0a2-4491-89e0-c3623e5dc377",[],[4041],{"id":4042,"sortIndex":36,"affiliation":4043,"properties":26},"d7fd0fef-65bd-4e42-8003-7ed06ed12fff",{"id":4044,"createTime":4045,"updateTime":4046,"relativeEntities":4047,"slug":4048,"properties":4049,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"dfba6b22-957d-4e5a-9727-ae150d003d1d","2024-01-10T04:53:22.352+00:00","2024-09-19T00:28:39.351+00:00",[],"Division-of-Clinical-Nutrition-National-Institute-of-Health-and-Nutrition-Tokyo-Japan",{"title":4050},{"VI":4051},"Division of Clinical Nutrition, National Institute of Health and Nutrition, Tokyo, Japan",{"openalex":4053,"orcid":4055,"title":4057},{"VOID":4054},"A5073474688",{"VOID":4056},"https:\u002F\u002Forcid.org\u002F0000-0001-7021-5507",{"EN":4058},"Nobuyo Tsuboyama-Kasaoka",{"id":4060,"sortIndex":111,"researcher":26,"roles":4061,"affiliations":4062,"properties":4069},"4efac5ed-f032-43ae-b8ad-26f8c882d8b3",[],[4063],{"id":4064,"sortIndex":36,"affiliation":4065,"properties":26},"b2792a90-f713-4e36-9c4f-e7a8a7b5ed3c",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":4066,"slug":3707,"properties":4067,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4068},{"VI":3710},{"openalex":4070,"orcid":4072,"title":4074},{"VOID":4071},"A5102945247",{"VOID":4073},"https:\u002F\u002Forcid.org\u002F0000-0002-3336-2767",{"EN":4075},"Naoto Kubota",{"id":4077,"sortIndex":116,"researcher":26,"roles":4078,"affiliations":4079,"properties":4086},"d314c2cb-5949-43e5-9749-218803d14ef2",[],[4080],{"id":4081,"sortIndex":36,"affiliation":4082,"properties":26},"11150379-ba2c-4494-9a06-6f2042b23f2a",{"id":4044,"createTime":4045,"updateTime":4046,"relativeEntities":4083,"slug":4048,"properties":4084,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4085},{"VI":4051},{"openalex":4087,"orcid":4089,"title":4091},{"VOID":4088},"A5061724024",{"VOID":4090},"https:\u002F\u002Forcid.org\u002F0000-0001-9394-9298",{"EN":4092},"Osamu Ezaki",{"id":4094,"sortIndex":242,"researcher":26,"roles":4095,"affiliations":4096,"properties":4103},"162edbed-db7a-4f86-9d22-e33557555025",[],[4097],{"id":4098,"sortIndex":36,"affiliation":4099,"properties":26},"41351564-c034-42ef-982f-cacb1bac8cba",{"id":3703,"createTime":3704,"updateTime":3705,"relativeEntities":4100,"slug":3707,"properties":4101,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4102},{"VI":3710},{"openalex":4104,"title":4106},{"VOID":4105},"A5023817300",{"EN":4107},"Ryozo Nagai",{"url":26,"publisher":4109,"properties":4139},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":4110,"slug":663,"properties":4111,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":4117,"manageAffiliations":4118,"indexDatabases":4119,"url":755,"thumbnailPath":26,"statistic":4134,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":4112,"issn":4113,"introduce":4114,"eissn":4115,"title":4116},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[4120,4127],{"id":736,"indexDatabase":4121,"url":749,"indexYears":750,"academicFieldIds":4126,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":4122,"label":4123,"description":4124,"key":746,"publicationTags":4125,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":4128,"url":730,"indexYears":26,"academicFieldIds":4133,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":4129,"label":4130,"description":4131,"key":726,"publicationTags":4132,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":4135,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":4136,"totalCitation":772,"totalCitationByYear":4137,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":4138,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":4140,"pages":4141,"issue":4143},{"VOID":1958},{"VOID":4142},"941-946",{"VOID":4144},"8",4821,{"total":4145,"publishYear":26,"statisticByYear":4147},{"2012":4148,"2013":4149,"2014":831,"2015":4150,"2016":150,"2017":121,"2018":802,"2019":4151,"2020":4152,"2021":633,"2022":127,"2023":4153,"2024":359},241,262,195,158,219,134,"2001-08-01",2001,[4157,4161,4165,4169,4173,4177,4181,4185,4189,4193,4196,4200,4204,4208,4212,4216,4220,4224,4228,4232,4236,4240,4244,4248,4252,4256,4260,4264,4268,4272,4276,4280,4284,4288,4292,4296,4300],{"id":26,"text":4158,"url":26,"identifiers":4159},"Friedman, J.M. Obesity in the new millennium. Nature 404, 632–634 (2000).",{"doi":4160},"10.1038\u002F35007504",{"id":26,"text":4162,"url":26,"identifiers":4163},"Hotamisligil, G.S. The role of TNFα and TNF receptors in obesity and insulin resistance. J. Intern. Med. 245, 621–625 (1999).",{"doi":4164},"10.1046\u002Fj.1365-2796.1999.00490.x",{"id":26,"text":4166,"url":26,"identifiers":4167},"Shimomura, I. et al. Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity. Nature Med. 2, 800–803 (1996).",{"doi":4168},"10.1038\u002Fnm0796-800",{"id":26,"text":4170,"url":26,"identifiers":4171},"White, R.T. et al. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J. Biol. Chem. 267, 9210–9213 (1992).",{"doi":4172},"10.1016\u002FS0021-9258(19)50409-4",{"id":26,"text":4174,"url":26,"identifiers":4175},"Steppan, C.M. et al. The hormone resistin links obesity to diabetes. Nature 409, 307–312 (2001).",{"doi":4176},"10.1038\u002F35053000",{"id":26,"text":4178,"url":26,"identifiers":4179},"Matsuzawa, Y., Funahashi, T. & Nakamura, T. Molecular mechanism of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances. Ann. NY Acad. Sci. 892, 146–154 (1999).",{"doi":4180},"10.1111\u002Fj.1749-6632.1999.tb07793.x",{"id":26,"text":4182,"url":26,"identifiers":4183},"Maeda, K. et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. 221, 286–296 (1996).",{"doi":4184},"10.1006\u002Fbbrc.1996.0587",{"id":26,"text":4186,"url":26,"identifiers":4187},"Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. & Lodish, H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746–26749 (1995).",{"doi":4188},"10.1074\u002Fjbc.270.45.26746",{"id":26,"text":4190,"url":26,"identifiers":4191},"Hu, E., Liang, P. & Spiegelman, B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697–10703 (1996).",{"doi":4192},"10.1074\u002Fjbc.271.18.10697",{"id":26,"text":4194,"url":26,"identifiers":4195},"Nakano, Y., Tobe, T., Choi-Miura, N.H., Mazda, T. & Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J. Biochem. (Tokyo) 120, 802–812 (1996).",{},{"id":26,"text":4197,"url":26,"identifiers":4198},"Arita, Y. et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257, 79–83 (1999).",{"doi":4199},"10.1006\u002Fbbrc.1999.0255",{"id":26,"text":4201,"url":26,"identifiers":4202},"Fruebis, J. et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. USA 98, 2005–2010 (2001).",{"doi":4203},"10.1073\u002Fpnas.98.4.2005",{"id":26,"text":4205,"url":26,"identifiers":4206},"Vionnet, N. et al. Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am. J. Hum. Genet. 67, 1470–1480 (2000).",{"doi":4207},"10.1086\u002F316887",{"id":26,"text":4209,"url":26,"identifiers":4210},"Kissebah, A.H. et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl. Acad. Sci. USA 97, 14478–14483 (2000).",{"doi":4211},"10.1073\u002Fpnas.97.26.14478",{"id":26,"text":4213,"url":26,"identifiers":4214},"Kubota, N. et al. PPAR-γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell 4, 597–609 (1999).",{"doi":4215},"10.1016\u002FS1097-2765(00)80210-5",{"id":26,"text":4217,"url":26,"identifiers":4218},"Miles, P.D., Barak, Y., He, W., Evans, R.M. & Olefsky, J.M. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J. Clin. Invest. 105, 287–292 (2000).",{"doi":4219},"10.1172\u002FJCI8538",{"id":26,"text":4221,"url":26,"identifiers":4222},"Ebisawa, M. et al. Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem. Pharm. Bull. (Tokyo) 47, 1778–1786 (1999).",{"doi":4223},"10.1248\u002Fcpb.47.1778",{"id":26,"text":4225,"url":26,"identifiers":4226},"Kersten, S., Desvergne, B. & Wahli, W. Roles of PPARs in health and disease. Nature 405, 421–424 (2000).",{"doi":4227},"10.1038\u002F35013000",{"id":26,"text":4229,"url":26,"identifiers":4230},"Spiegelman, B.M. & Flier, J.S. Adipogenesis and obesity: Rounding out the big picture. Cell 87, 377–389 (1996).",{"doi":4231},"10.1016\u002FS0092-8674(00)81359-8",{"id":26,"text":4233,"url":26,"identifiers":4234},"Schoonjans, K. et al. PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15, 5336–5348 (1996).",{"doi":4235},"10.1002\u002Fj.1460-2075.1996.tb00918.x",{"id":26,"text":4237,"url":26,"identifiers":4238},"Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S. & Goldstein, J.L. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401, 73–76 (1999).",{"doi":4239},"10.1038\u002F43448",{"id":26,"text":4241,"url":26,"identifiers":4242},"Gavrilova, O. et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J. Clin. Invest. 105, 271–278 (2000).",{"doi":4243},"10.1172\u002FJCI7901",{"id":26,"text":4245,"url":26,"identifiers":4246},"Seip, M. & Trygstad, O. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr. Suppl. 413, 2–28 (1996).",{"doi":4247},"10.1111\u002Fj.1651-2227.1996.tb14262.x",{"id":26,"text":4249,"url":26,"identifiers":4250},"Eggleton, P., Reid, K.B. & Tenner, A.J. C1q—how many functions? How many receptors? Trends Cell. Biol. 8, 428–431 (1998).",{"doi":4251},"10.1016\u002FS0962-8924(98)01373-7",{"id":26,"text":4253,"url":26,"identifiers":4254},"Shapiro, L. & Scherer, P.E. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 8, 335–338 (1998).",{"doi":4255},"10.1016\u002FS0960-9822(98)70133-2",{"id":26,"text":4257,"url":26,"identifiers":4258},"Motojima, K., Passilly, P., Peters, J.M., Gonzalez, F.J. & Latruffe, N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner. J. Biol. Chem. 273, 16710–16714 (1998).",{"doi":4259},"10.1074\u002Fjbc.273.27.16710",{"id":26,"text":4261,"url":26,"identifiers":4262},"Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A. & Evans, R.M. PPARγ promotes monocyte\u002Fmacrophage differentiation and uptake of oxidized LDL. Cell 93, 241–252 (1998).",{"doi":4263},"10.1016\u002FS0092-8674(00)81575-5",{"id":26,"text":4265,"url":26,"identifiers":4266},"Murakami, K. et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ: Effect of PPAR-α activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes 47, 1841–1847 (1998).",{"doi":4267},"10.2337\u002Fdiabetes.47.12.1841",{"id":26,"text":4269,"url":26,"identifiers":4270},"Kersten, S. et al. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 103, 1489–1498 (1999).",{"doi":4271},"10.1172\u002FJCI6223",{"id":26,"text":4273,"url":26,"identifiers":4274},"Lowell, B.B. & Spiegelman, B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652–660 (2000).",{"doi":4275},"10.1038\u002F35007527",{"id":26,"text":4277,"url":26,"identifiers":4278},"Kelly, L.J. et al. Peroxisome proliferator-activated receptors γ and α mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology 139, 4920–4927 (1998).",{"doi":4279},"10.1210\u002Fendo.139.12.6384",{"id":26,"text":4281,"url":26,"identifiers":4282},"Shulman, G.I. Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171–176 (2000).",{"doi":4283},"10.1172\u002FJCI10583",{"id":26,"text":4285,"url":26,"identifiers":4286},"Masuzaki, H. et al. Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: Usefulness of leptin for the treatment of obesity-associated diabetes. Diabetes 48, 1615–1622 (1999).",{"doi":4287},"10.2337\u002Fdiabetes.48.8.1615",{"id":26,"text":4289,"url":26,"identifiers":4290},"Kahn, C.R., Vicent, D. & Doria, A. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annu. Rev. Med. 47, 509–31 (1996).",{"doi":4291},"10.1146\u002Fannurev.med.47.1.509",{"id":26,"text":4293,"url":26,"identifiers":4294},"Ouchi, N. et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation 102, 1296–301 (2000).",{"doi":4295},"10.1161\u002F01.CIR.102.11.1296",{"id":26,"text":4297,"url":26,"identifiers":4298},"Yamauchi, T. et al. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell. Biol. 16, 3074–3084 (1996).",{"doi":4299},"10.1128\u002FMCB.16.6.3074",{"id":26,"text":4301,"url":26,"identifiers":4302},"Mondon, C.E., Dolkas, C.B. & Oyama, J. Enhanced skeletal muscle insulin sensitivity in year-old rats adapted to hypergravity. Am. J. Physiol. 240, E482–488 (1981).",{},{"id":4304,"createTime":4305,"updateTime":4305,"relativeEntities":4306,"slug":4307,"properties":4308,"entityType":854,"verifyStatus":25,"verifyTime":4305,"verifyNote":855,"syncStatus":28,"languages":4321,"translateLanguages":26,"viewCount":36,"primaryUrl":4322,"fullTextUrl":26,"authors":4323,"publicationType":918,"publisherRelationship":4362,"citationCount":4399,"citationInfo":4400,"publishDate":4410,"publishYear":4411,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":4412,"isForceReanalyzing":1501},"afb65866-72cc-4ea2-ab69-ffc5e27a3897","2024-10-05T19:15:48.120+00:00",[],"Cancer-genes-and-the-pathways-they-control",{"mag":4309,"keywords":4311,"openalex":4312,"abstract":4314,"title":4315,"pm":4317,"doi":4319},{"VOID":4310},"2011912935",{},{"VOID":4313},"W2011912935",{},{"EN":4316},"Cancer genes and the pathways they control",{"VOID":4318},"15286780",{"VOID":4320},"10.1038\u002Fnm1087",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm1087",[4324,4345],{"id":4325,"sortIndex":115,"researcher":26,"roles":4326,"affiliations":4327,"properties":4338},"3a11a81e-caa3-4c0a-b37c-09fa869cbc70",[],[4328],{"id":4329,"sortIndex":36,"affiliation":4330,"properties":26},"eae0e85f-c226-4d4e-a17e-339c10e84449",{"id":4331,"createTime":4332,"updateTime":4332,"relativeEntities":4333,"slug":4334,"properties":4335,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e56e8e13-2c6d-4c0c-97a2-805fcc71fee2","2024-10-05T19:15:48.144+00:00",[],"Howard-Hughes-Medical-Institute-and-The-Sidney-Kimmel-Comprehensive-Cancer-Center-The-Johns-Hopkins-University-Medical-Institutions-Baltimore-USA",{"title":4336},{"EN":4337},"Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, USA",{"openalex":4339,"orcid":4341,"title":4343},{"VOID":4340},"A5059462255",{"VOID":4342},"https:\u002F\u002Forcid.org\u002F0000-0001-5591-1176",{"EN":4344},"Kenneth W. Kinzler",{"id":4346,"sortIndex":36,"researcher":26,"roles":4347,"affiliations":4348,"properties":4355},"13aed0cd-ca7c-46d2-88d8-ff9cf4ca3c8f",[],[4349],{"id":4350,"sortIndex":36,"affiliation":4351,"properties":26},"13f3d3a4-50e7-4f48-998e-2abef59b03bb",{"id":4331,"createTime":4332,"updateTime":4332,"relativeEntities":4352,"slug":4334,"properties":4353,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4354},{"EN":4337},{"openalex":4356,"orcid":4358,"title":4360},{"VOID":4357},"A5072858943",{"VOID":4359},"https:\u002F\u002Forcid.org\u002F0000-0003-0766-3854",{"EN":4361},"Bert Vogelstein",{"url":26,"publisher":4363,"properties":4393},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":4364,"slug":663,"properties":4365,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":4371,"manageAffiliations":4372,"indexDatabases":4373,"url":755,"thumbnailPath":26,"statistic":4388,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":4366,"issn":4367,"introduce":4368,"eissn":4369,"title":4370},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[4374,4381],{"id":736,"indexDatabase":4375,"url":749,"indexYears":750,"academicFieldIds":4380,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":4376,"label":4377,"description":4378,"key":746,"publicationTags":4379,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":4382,"url":730,"indexYears":26,"academicFieldIds":4387,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":4383,"label":4384,"description":4385,"key":726,"publicationTags":4386,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":4389,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":4390,"totalCitation":772,"totalCitationByYear":4391,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":4392,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":4394,"pages":4396,"issue":4398},{"VOID":4395},"10",{"VOID":4397},"789-799",{"VOID":4144},4113,{"total":4399,"publishYear":26,"statisticByYear":4401},{"2012":769,"2013":4402,"2014":4403,"2015":4404,"2016":4405,"2017":4406,"2018":518,"2019":1590,"2020":4407,"2021":161,"2022":4408,"2023":4409,"2024":359},264,282,245,218,154,163,148,104,"2004-08-01",2004,[4413,4417,4421,4424,4428,4432,4436,4440,4444,4448,4451,4454,4458,4461,4465,4469,4473,4477,4481,4485,4489,4493,4497,4501,4505,4509,4513,4515,4519,4523,4527,4531,4535,4539,4543,4547,4551,4555,4559,4563,4567,4571,4575,4579,4583,4587,4591,4595,4599,4602,4606,4609,4613,4617,4620,4624,4627,4631,4634,4638,4642,4646,4650,4654,4658,4662,4666,4670,4674,4678,4682,4686,4690,4694,4698,4702,4706,4710,4714,4718,4722,4726,4730,4734,4737,4741,4744,4748,4751,4755,4759,4763,4767,4771,4775,4779,4783,4786,4790,4794,4798,4802,4806,4810,4814,4818,4821,4825,4829,4833,4837,4840,4844,4848,4852,4856,4860,4863],{"id":26,"text":4414,"url":26,"identifiers":4415},"Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949–954 (2002).",{"doi":4416},"10.1038\u002Fnature00766",{"id":26,"text":4418,"url":26,"identifiers":4419},"Wan, P.T. et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116, 855–867 (2004).",{"doi":4420},"10.1016\u002FS0092-8674(04)00215-6",{"id":26,"text":4422,"url":26,"identifiers":4423},"Santarosa, M. & Ashworth, A. Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way. Biochim. Biophys. Acta 1654, 105–122 (2004).",{},{"id":26,"text":4425,"url":26,"identifiers":4426},"Knudson, A.G. Cancer genetics. Am. J. Med. Genet. 111, 96–102 (2002).",{"doi":4427},"10.1002\u002Fajmg.10320",{"id":26,"text":4429,"url":26,"identifiers":4430},"Friedberg, E.C. DNA damage and repair. Nature 421, 436–440 (2003).",{"doi":4431},"10.1038\u002Fnature01408",{"id":26,"text":4433,"url":26,"identifiers":4434},"Nowell, P.C. Tumor progression: a brief historical perspective. Semin. Cancer Biol. 12, 261–266 (2002).",{"doi":4435},"10.1016\u002FS1044-579X(02)00012-3",{"id":26,"text":4437,"url":26,"identifiers":4438},"Maley, C.C. et al. Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus. Cancer Res. 64, 3414–3427 (2004).",{"doi":4439},"10.1158\u002F0008-5472.CAN-03-3249",{"id":26,"text":4441,"url":26,"identifiers":4442},"Van Dyke, T. & Jacks, T. Cancer modeling in the modern era: progress and challenges. Cell 108, 135–144 (2002).",{"doi":4443},"10.1016\u002FS0092-8674(02)00621-9",{"id":26,"text":4445,"url":26,"identifiers":4446},"Horvitz, H.R. Worms, life, and death. Chembiochem 4, 697–711 (2003).",{"doi":4447},"10.1002\u002Fcbic.200300614",{"id":26,"text":4449,"url":26,"identifiers":4450},"Sherr, C.J. Cancer cell cycles revisited. Cancer Res. 60, 3689–3695 (2000).",{},{"id":26,"text":4452,"url":26,"identifiers":4453},"Ortega, S., Malumbres, M. & Barbacid, M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim. Biophys. Acta 1602, 73–87 (2002).",{},{"id":26,"text":4455,"url":26,"identifiers":4456},"Classon, M. & Harlow, E. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer 2, 910–917 (2002).",{"doi":4457},"10.1038\u002Fnrc950",{"id":26,"text":4459,"url":26,"identifiers":4460},"Ichimura, K. et al. Deregulation of the p14ARF\u002FMDM2\u002Fp53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res. 60, 417–424 (2000).",{},{"id":26,"text":4462,"url":26,"identifiers":4463},"Vogelstein, B., Lane, D. & Levine, A.J. Surfing the p53 network. Nature 408, 307–310 (2000).",{"doi":4464},"10.1038\u002F35042675",{"id":26,"text":4466,"url":26,"identifiers":4467},"Oren, M. Decision making by p53: life, death and cancer. Cell Death Differ. 10, 431–442 (2003).",{"doi":4468},"10.1038\u002Fsj.cdd.4401183",{"id":26,"text":4470,"url":26,"identifiers":4471},"Prives, C. & Hall, P.A. The p53 pathway. J. Pathol. 187, 112–126 (1999).",{"doi":4472},"10.1002\u002F(SICI)1096-9896(199901)187:1\u003C112::AID-PATH250>3.0.CO;2-3",{"id":26,"text":4474,"url":26,"identifiers":4475},"Klein, G. Perspectives in studies of human tumor viruses. Front. Biosci. 7, d268–d274 (2002).",{"doi":4476},"10.2741\u002FA726",{"id":26,"text":4478,"url":26,"identifiers":4479},"Munger, K. & Howley, P.M. Human papillomavirus immortalization and transformation functions. Virus Res. 89, 213–228 (2002).",{"doi":4480},"10.1016\u002FS0168-1702(02)00190-9",{"id":26,"text":4482,"url":26,"identifiers":4483},"zur Hausen, H. Oncogenic DNA viruses. Oncogene 20, 7820–7823 (2001).",{"doi":4484},"10.1038\u002Fsj.onc.1204958",{"id":26,"text":4486,"url":26,"identifiers":4487},"Hunter, T. Signaling–2000 and beyond. Cell 100, 113–127 (2000).",{"doi":4488},"10.1016\u002FS0092-8674(00)81688-8",{"id":26,"text":4490,"url":26,"identifiers":4491},"Komarova, N.L., Sengupta, A. & Nowak, M.A. Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. J. Theor. Biol. 223, 433–450 (2003).",{"doi":4492},"10.1016\u002FS0022-5193(03)00120-6",{"id":26,"text":4494,"url":26,"identifiers":4495},"Rowley, J.D. The critical role of chromosome translocations in human leukemias. Annu. Rev. Genet. 32, 495–519 (1998).",{"doi":4496},"10.1146\u002Fannurev.genet.32.1.495",{"id":26,"text":4498,"url":26,"identifiers":4499},"Mitelman, F. Recurrent chromosome aberrations in cancer. Mutat. Res. 462, 247–253 (2000).",{"doi":4500},"10.1016\u002FS1383-5742(00)00006-5",{"id":26,"text":4502,"url":26,"identifiers":4503},"Verheul, H.M., Voest, E.E. & Schlingemann, R.O. Are tumours angiogenesis-dependent? J. Pathol. 202, 5–13 (2004).",{"doi":4504},"10.1002\u002Fpath.1473",{"id":26,"text":4506,"url":26,"identifiers":4507},"Tlsty, T.D. & Hein, P.W. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr. Opin. Genet. Dev. 11, 54–59 (2001).",{"doi":4508},"10.1016\u002FS0959-437X(00)00156-8",{"id":26,"text":4510,"url":26,"identifiers":4511},"Fata, J.E., Werb, Z. & Bissell, M.J. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 6, 1–11 (2004).",{"doi":4512},"10.1186\u002Fbcr634",{"id":26,"text":1482,"url":26,"identifiers":4514},{"doi":1484},{"id":26,"text":4516,"url":26,"identifiers":4517},"Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29, 15–18 (2002).",{"doi":4518},"10.1053\u002Fsonc.2002.37263",{"id":26,"text":4520,"url":26,"identifiers":4521},"Ferrara, N., Hillan, K.J., Gerber, H.P. & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3, 391–400 (2004).",{"doi":4522},"10.1038\u002Fnrd1381",{"id":26,"text":4524,"url":26,"identifiers":4525},"Kondo, K., Klco, J., Nakamura, E., Lechpammer, M. & Kaelin, W.G. Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1, 237–246 (2002).",{"doi":4526},"10.1016\u002FS1535-6108(02)00043-0",{"id":26,"text":4528,"url":26,"identifiers":4529},"Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721–732 (2003).",{"doi":4530},"10.1038\u002Fnrc1187",{"id":26,"text":4532,"url":26,"identifiers":4533},"Strausberg, R.L., Simpson, A.J. & Wooster, R. Sequence-based cancer genomics: progress, lessons and opportunities. Nat. Rev. Genet. 4, 409–418 (2003).",{"doi":4534},"10.1038\u002Fnrg1085",{"id":26,"text":4536,"url":26,"identifiers":4537},"Loeb, L.A., Loeb, K.R. & Anderson, J.P. Multiple mutations and cancer. Proc. Natl. Acad. Sci. USA 100, 776–781 (2003).",{"doi":4538},"10.1073\u002Fpnas.0334858100",{"id":26,"text":4540,"url":26,"identifiers":4541},"Rajagopalan, H., Nowak, M.A., Vogelstein, B. & Lengauer, C. The significance of unstable chromosomes in colorectal cancer. Nat. Rev. Cancer 3, 695–701 (2003).",{"doi":4542},"10.1038\u002Fnrc1165",{"id":26,"text":4544,"url":26,"identifiers":4545},"Sieber, O.M., Heinimann, K. & Tomlinson, I.P. Genomic instability—the engine of tumorigenesis? Nat. Rev. Cancer 3, 701–708 (2003).",{"doi":4546},"10.1038\u002Fnrc1170",{"id":26,"text":4548,"url":26,"identifiers":4549},"Wang, T.L. et al. Prevalence of somatic alterations in the colorectal cancer cell genome. Proc. Natl. Acad. Sci. USA 99, 3076–3080 (2002).",{"doi":4550},"10.1073\u002Fpnas.261714699",{"id":26,"text":4552,"url":26,"identifiers":4553},"Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643–649 (1998).",{"doi":4554},"10.1038\u002F25292",{"id":26,"text":4556,"url":26,"identifiers":4557},"Duesberg, P. & Li, R. Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle 2, 202–210 (2003).",{"doi":4558},"10.4161\u002Fcc.2.3.382",{"id":26,"text":4560,"url":26,"identifiers":4561},"Albertson, D.G. & Pinkel, D. Genomic microarrays in human genetic disease and cancer. Hum. Mol. Genet. 12 (spec. no. 2), R145–R152 (2003).",{"doi":4562},"10.1093\u002Fhmg\u002Fddg261",{"id":26,"text":4564,"url":26,"identifiers":4565},"Shiloh, Y. & Kastan, M.B. ATM: genome stability, neuronal development, and cancer cross paths. Adv. Cancer Res. 83, 209–254 (2001).",{"doi":4566},"10.1016\u002FS0065-230X(01)83007-4",{"id":26,"text":4568,"url":26,"identifiers":4569},"Scully, R. & Livingston, D.M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429–432 (2000).",{"doi":4570},"10.1038\u002F35044000",{"id":26,"text":4572,"url":26,"identifiers":4573},"Maser, R.S. & DePinho, R.A. Connecting chromosomes, crisis, and cancer. Science 297, 565–569 (2002).",{"doi":4574},"10.1126\u002Fscience.297.5581.565",{"id":26,"text":4576,"url":26,"identifiers":4577},"Pihan, G. & Doxsey, S.J. Mutations and aneuploidy: co-conspirators in cancer? Cancer Cell 4, 89–94 (2003).",{"doi":4578},"10.1016\u002FS1535-6108(03)00195-8",{"id":26,"text":4580,"url":26,"identifiers":4581},"Rajagopalan, H. et al. Inactivation of hCDC4 can cause chromosomal instability. Nature 428, 77–81 (2004).",{"doi":4582},"10.1038\u002Fnature02313",{"id":26,"text":4584,"url":26,"identifiers":4585},"Shay, J.W. & Roninson, I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23, 2919–2933 (2004).",{"doi":4586},"10.1038\u002Fsj.onc.1207518",{"id":26,"text":4588,"url":26,"identifiers":4589},"Chambers, A.F., Groom, A.C. & MacDonald, I.C. Dissemination and growth of cancer cells in metastatic sites. Nat. Rev. Cancer 2, 563–572 (2002).",{"doi":4590},"10.1038\u002Fnrc865",{"id":26,"text":4592,"url":26,"identifiers":4593},"Fidler, I.J. Critical determinants of metastasis. Semin. Cancer Biol. 12, 89–96 (2002).",{"doi":4594},"10.1006\u002Fscbi.2001.0416",{"id":26,"text":4596,"url":26,"identifiers":4597},"Hunter, K.W. Host genetics and tumour metastasis. Br. J. Cancer 90, 752–755 (2004).",{"doi":4598},"10.1038\u002Fsj.bjc.6601590",{"id":26,"text":4600,"url":26,"identifiers":4601},"Hruban, R.H., Goggins, M., Parsons, J. & Kern, S.E. Progression model for pancreatic cancer. Clin. Cancer Res. 6, 2969–2972 (2000).",{},{"id":26,"text":4603,"url":26,"identifiers":4604},"Aguirre, A.J. et al. Activated Kras and Ink4a\u002FArf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 17, 3112–3126 (2003).",{"doi":4605},"10.1101\u002Fgad.1158703",{"id":26,"text":4607,"url":26,"identifiers":4608},"Jen, J. et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res. 54, 5523–5526 (1994).",{},{"id":26,"text":4610,"url":26,"identifiers":4611},"Pretlow, T.P. Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis? Gastroenterology 108, 600–603 (1995).",{"doi":4612},"10.1016\u002F0016-5085(95)90092-6",{"id":26,"text":4614,"url":26,"identifiers":4615},"Sieben, N.L. et al. In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J. Pathol. 202, 336–340 (2004).",{"doi":4616},"10.1002\u002Fpath.1521",{"id":26,"text":4618,"url":26,"identifiers":4619},"Kinzler, K.W. & Vogelstein, B. Colorectal Tumors. in The Genetic Basis of Human Cancer (eds. Vogelstein, B. & Kinzler, K.W.) 565–587 (McGraw-Hill, New York, 1998).",{},{"id":26,"text":4621,"url":26,"identifiers":4622},"Barbacid, M. ras genes. Annu. Rev. Biochem. 56, 779–827 (1987).",{"doi":4623},"10.1146\u002Fannurev.bi.56.070187.004023",{"id":26,"text":4625,"url":26,"identifiers":4626},"Bos, J.L. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682–4689 (1989).",{},{"id":26,"text":4628,"url":26,"identifiers":4629},"Zhang, Z. et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat. Genet. 29, 25–33 (2001).",{"doi":4630},"10.1038\u002Fng721",{"id":26,"text":4632,"url":26,"identifiers":4633},"Diaz, R. et al. The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res. 62, 4514–4518 (2002).",{},{"id":26,"text":4635,"url":26,"identifiers":4636},"Bronner-Fraser, M. Development. Making sense of the sensory lineage. Science 303, 966–968 (2004).",{"doi":4637},"10.1126\u002Fscience.1094732",{"id":26,"text":4639,"url":26,"identifiers":4640},"Jiricny, J. Eukaryotic mismatch repair: an update. Mutat. Res. 409, 107–121 (1998).",{"doi":4641},"10.1016\u002FS0921-8777(98)00056-1",{"id":26,"text":4643,"url":26,"identifiers":4644},"Fishel, R. & Wilson, T. MutS homologs in mammalian cells. Curr. Opin. Genet. Dev. 7, 105–113 (1997).",{"doi":4645},"10.1016\u002FS0959-437X(97)80117-7",{"id":26,"text":4647,"url":26,"identifiers":4648},"Lynch, H.T. & de la Chapelle, A. Hereditary colorectal cancer. N. Engl. J. Med. 348, 919–932 (2003).",{"doi":4649},"10.1056\u002FNEJMra012242",{"id":26,"text":4651,"url":26,"identifiers":4652},"Yamamoto, H., Imai, K. & Perucho, M. Gastrointestinal cancer of the microsatellite mutator phenotype pathway. J. Gastroenterol. 37, 153–163 (2002).",{"doi":4653},"10.1007\u002Fs005350200015",{"id":26,"text":4655,"url":26,"identifiers":4656},"Honchel, R., Halling, K.C. & Thibodeau, S.N. Genomic instability in neoplasia. Semin. Cell Biol. 6, 45–52 (1995).",{"doi":4657},"10.1016\u002F1043-4682(95)90014-4",{"id":26,"text":4659,"url":26,"identifiers":4660},"Brown, P.O. & Botstein, D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21, 33–37 (1999).",{"doi":4661},"10.1038\u002F4462",{"id":26,"text":4663,"url":26,"identifiers":4664},"Polyak, K. & Riggins, G.J. Gene discovery using the serial analysis of gene expression technique: implications for cancer research. J. Clin. Oncol. 19, 2948–2958 (2001).",{"doi":4665},"10.1200\u002FJCO.2001.19.11.2948",{"id":26,"text":4667,"url":26,"identifiers":4668},"Jones, P.A. & Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415–428 (2002).",{"doi":4669},"10.1038\u002Fnrg816",{"id":26,"text":4671,"url":26,"identifiers":4672},"Feinberg, A.P. & Tycko, B. The history of cancer epigenetics. Nat. Rev. Cancer 4, 143–153 (2004).",{"doi":4673},"10.1038\u002Fnrc1279",{"id":26,"text":4675,"url":26,"identifiers":4676},"Collins, F.S., Green, E.D., Guttmacher, A.E. & Guyer, M.S. A vision for the future of genomics research. Nature 422, 835–847 (2003).",{"doi":4677},"10.1038\u002Fnature01626",{"id":26,"text":4679,"url":26,"identifiers":4680},"Schadt, E.E., Monks, S.A. & Friend, S.H. A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. Biochem. Soc. Trans. 31, 437–443 (2003).",{"doi":4681},"10.1042\u002Fbst0310437",{"id":26,"text":4683,"url":26,"identifiers":4684},"Paddison, P.J. et al. A resource for large-scale RNA-interference-based screens in mammals. Nature 428, 427–431 (2004).",{"doi":4685},"10.1038\u002Fnature02370",{"id":26,"text":4687,"url":26,"identifiers":4688},"Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431–437 (2004).",{"doi":4689},"10.1038\u002Fnature02371",{"id":26,"text":4691,"url":26,"identifiers":4692},"Rosenblatt, K.P. et al. Serum proteomics in cancer diagnosis and management. Annu. Rev. Med. 55, 97–112 (2004).",{"doi":4693},"10.1146\u002Fannurev.med.55.091902.105237",{"id":26,"text":4695,"url":26,"identifiers":4696},"Luo, J., Isaacs, W.B., Trent, J.M. & Duggan, D.J. Looking beyond morphology: cancer gene expression profiling using DNA microarrays. Cancer Invest. 21, 937–949 (2003).",{"doi":4697},"10.1081\u002FCNV-120025096",{"id":26,"text":4699,"url":26,"identifiers":4700},"Ma, X.J. et al. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 5, 607–616 (2004).",{"doi":4701},"10.1016\u002Fj.ccr.2004.05.015",{"id":26,"text":4703,"url":26,"identifiers":4704},"Futreal, P.A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177–183 (2004).",{"doi":4705},"10.1038\u002Fnrc1299",{"id":26,"text":4707,"url":26,"identifiers":4708},"Masayesva, B.G. et al. Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc. Natl. Acad. Sci. USA 101, 8715–8720 (2004).",{"doi":4709},"10.1073\u002Fpnas.0400027101",{"id":26,"text":4711,"url":26,"identifiers":4712},"Stewart, S.A. & Weinberg, R.A. Senescence: does it all happen at the ends? Oncogene 21, 627–630 (2002).",{"doi":4713},"10.1038\u002Fsj.onc.1205062",{"id":26,"text":4715,"url":26,"identifiers":4716},"Feldser, D.M., Hackett, J.A. & Greider, C.W. Telomere dysfunction and the initiation of genome instability. Nat. Rev. Cancer 3, 623–627 (2003).",{"doi":4717},"10.1038\u002Fnrc1142",{"id":26,"text":4719,"url":26,"identifiers":4720},"Chan, S.R. & Blackburn, E.H. Telomeres and telomerase. Phil. Trans. R. Soc. Lond. B 359, 109–121 (2004).",{"doi":4721},"10.1098\u002Frstb.2003.1370",{"id":26,"text":4723,"url":26,"identifiers":4724},"Cech, T.R. Beginning to understand the end of the chromosome. Cell 116, 273–279 (2004).",{"doi":4725},"10.1016\u002FS0092-8674(04)00038-8",{"id":26,"text":4727,"url":26,"identifiers":4728},"Miklos, G.L. & Maleszka, R. Microarray reality checks in the context of a complex disease. Nat. Biotechnol. 22, 615–621 (2004).",{"doi":4729},"10.1038\u002Fnbt965",{"id":26,"text":4731,"url":26,"identifiers":4732},"Hope, K.J., Jin, L. & Dick, J.E. Human acute myeloid leukemia stem cells. Arch. Med. Res. 34, 507–514 (2003).",{"doi":4733},"10.1016\u002Fj.arcmed.2003.08.007",{"id":26,"text":4735,"url":26,"identifiers":4736},"Berking, C. & Herlyn, M. Human skin reconstruct models: a new application for studies of melanocyte and melanoma biology. Histol. Histopathol. 16, 669–674 (2001).",{},{"id":26,"text":4738,"url":26,"identifiers":4739},"Kuperwasser, C. et al. Reconstruction of functionally normal and malignant human breast tissues in mice. Proc. Natl Acad. Sci. USA 101, 4966–4971 (2004).",{"doi":4740},"10.1073\u002Fpnas.0401064101",{"id":26,"text":4742,"url":26,"identifiers":4743},"Frei, E.I. & Eder, J.P. Principles of dose, schedule, and combination Therapy. in Cancer Medicine (eds. Kufe, D.W. et al.) 669–677 (B.C. Decker, Inc., Hamilton, Ontario, 2003).",{},{"id":26,"text":4745,"url":26,"identifiers":4746},"Pegram, M.D., Konecny, G. & Slamon, D.J. The molecular and cellular biology of HER2\u002Fneu gene amplification\u002Foverexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat. Res. 103, 57–75 (2000).",{"doi":4747},"10.1007\u002F978-1-4757-3147-7_4",{"id":26,"text":4749,"url":26,"identifiers":4750},"Druker, B.J. et al. Chronic myelogenous leukemia. in Hematology 2001 (American Society of Hematology Education Program) 87–112 (American Society of Hematology, 2001).",{},{"id":26,"text":4752,"url":26,"identifiers":4753},"Mechtersheimer, G. et al. Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib. Virchows Arch. 444, 108–118 (2004).",{"doi":4754},"10.1007\u002Fs00428-003-0945-5",{"id":26,"text":4756,"url":26,"identifiers":4757},"Langer, C.J. Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. Int. J. Radiat. Oncol. Biol. Phys. 58, 991–1002 (2004).",{"doi":4758},"10.1016\u002Fj.ijrobp.2003.09.099",{"id":26,"text":4760,"url":26,"identifiers":4761},"Duensing, A., Heinrich, M.C., Fletcher, C.D. & Fletcher, J.A. Biology of gastrointestinal stromal tumors: KIT mutations and beyond. Cancer Invest. 22, 106–116 (2004).",{"doi":4762},"10.1081\u002FCNV-120027585",{"id":26,"text":4764,"url":26,"identifiers":4765},"Paez, J.G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497–1500 (2004).",{"doi":4766},"10.1126\u002Fscience.1099314",{"id":26,"text":4768,"url":26,"identifiers":4769},"Lynch, T.J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129–2139 (2004).",{"doi":4770},"10.1056\u002FNEJMoa040938",{"id":26,"text":4772,"url":26,"identifiers":4773},"Schmitt, C.A. & Lowe, S.W. Apoptosis and therapy. J. Pathol. 187, 127–137 (1999).",{"doi":4774},"10.1002\u002F(SICI)1096-9896(199901)187:1\u003C127::AID-PATH251>3.0.CO;2-T",{"id":26,"text":4776,"url":26,"identifiers":4777},"Danial, N.N. & Korsmeyer, S.J. Cell death: critical control points. Cell 116, 205–219 (2004).",{"doi":4778},"10.1016\u002FS0092-8674(04)00046-7",{"id":26,"text":4780,"url":26,"identifiers":4781},"Brown, J.M. & Wouters, B.G. Apoptosis: mediator or mode of cell killing by anticancer agents? Drug Resist. Updat. 4, 135–136 (2001).",{"doi":4782},"10.1054\u002Fdrup.2001.0193",{"id":26,"text":4784,"url":26,"identifiers":4785},"Weinstein, I.B. et al. Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. Clin. Cancer Res. 3, 2696–2702 (1997).",{},{"id":26,"text":4787,"url":26,"identifiers":4788},"Nygren, P. & Larsson, R. Overview of the clinical efficacy of investigational anticancer drugs. J. Intern. Med. 253, 46–75 (2003).",{"doi":4789},"10.1046\u002Fj.1365-2796.2003.01098.x",{"id":26,"text":4791,"url":26,"identifiers":4792},"Shih, L.Y. et al. Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples. Clin. Cancer Res. 10, 1326–1332 (2004).",{"doi":4793},"10.1158\u002F1078-0432.CCR-0835-03",{"id":26,"text":4795,"url":26,"identifiers":4796},"Kinzler, K.W. & Vogelstein, B. Lessons from hereditary colon cancer. Cell 87, 159–170 (1996).",{"doi":4797},"10.1016\u002FS0092-8674(00)81333-1",{"id":26,"text":4799,"url":26,"identifiers":4800},"Weissleder, R. & Ntziachristos, V. Shedding light onto live molecular targets. Nat. Med. 9, 123–128 (2003).",{"doi":4801},"10.1038\u002Fnm0103-123",{"id":26,"text":4803,"url":26,"identifiers":4804},"Sidransky, D. Emerging molecular markers of cancer. Nat. Rev. Cancer 2, 210–219 (2002).",{"doi":4805},"10.1038\u002Fnrc755",{"id":26,"text":4807,"url":26,"identifiers":4808},"Gschwind, A., Fischer, O.M. & Ullrich, A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat. Rev. Cancer 4, 361–370 (2004).",{"doi":4809},"10.1038\u002Fnrc1360",{"id":26,"text":4811,"url":26,"identifiers":4812},"Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11–22 (2003).",{"doi":4813},"10.1038\u002Fnrc969",{"id":26,"text":4815,"url":26,"identifiers":4816},"Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1, 222–231 (2001).",{"doi":4817},"10.1038\u002F35106065",{"id":26,"text":4819,"url":26,"identifiers":4820},"Giles, R.H., van Es, J.H. & Clevers, H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 1653, 1–24 (2003).",{},{"id":26,"text":4822,"url":26,"identifiers":4823},"Cantley, L.C. The phosphoinositide 3-kinase pathway. Science 296, 1655–1657 (2002).",{"doi":4824},"10.1126\u002Fscience.296.5573.1655",{"id":26,"text":4826,"url":26,"identifiers":4827},"Shi, Y. & Massague, J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685–700 (2003).",{"doi":4828},"10.1016\u002FS0092-8674(03)00432-X",{"id":26,"text":4830,"url":26,"identifiers":4831},"Ruiz i Altaba. A., Stecca, B. & Sanchez, P. Hedgehog–Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer. Cancer Lett. 204, 145–157 (2004).",{"doi":4832},"10.1016\u002FS0304-3835(03)00451-8",{"id":26,"text":4834,"url":26,"identifiers":4835},"Adams, J.M. Ways of dying: multiple pathways to apoptosis. Genes Dev. 17, 2481–2495 (2003).",{"doi":4836},"10.1101\u002Fgad.1126903",{"id":26,"text":4838,"url":26,"identifiers":4839},"Blagosklonny, M.V. & Pardee, A.B. The restriction point of the cell cycle. Cell Cycle 1, 103–110 (2002).",{},{"id":26,"text":4841,"url":26,"identifiers":4842},"Plas, D.R. & Thompson, C.B. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol. Metab. 13, 75–78 (2002).",{"doi":4843},"10.1016\u002FS1043-2760(01)00528-8",{"id":26,"text":4845,"url":26,"identifiers":4846},"Green, D.R. & Evan, G.I. A matter of life and death. Cancer Cell 1, 19–30 (2002).",{"doi":4847},"10.1016\u002FS1535-6108(02)00024-7",{"id":26,"text":4849,"url":26,"identifiers":4850},"Eng, C., Kiuru, M., Fernandez, M.J. & Aaltonen, L.A. A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat. Rev. Cancer 3, 193–202 (2003).",{"doi":4851},"10.1038\u002Fnrc1013",{"id":26,"text":4853,"url":26,"identifiers":4854},"Lum, L. & Beachy, P.A. The Hedgehog response network: sensors, switches, and routers. Science 304, 1755–1759 (2004).",{"doi":4855},"10.1126\u002Fscience.1098020",{"id":26,"text":4857,"url":26,"identifiers":4858},"Brivanlou, A.H. & Darnell, J.E. Jr. Signal transduction and the control of gene expression. Science 295, 813–818 (2002).",{"doi":4859},"10.1126\u002Fscience.1066355",{"id":26,"text":4861,"url":26,"identifiers":4862},"Vogelstein, B. & Kinzler, K.W. The Genetic Basis of Human Cancer (McGraw-Hill, Toronto, 2002).",{},{"id":26,"text":4864,"url":26,"identifiers":4865},"Cameron, E.R. & Neil, J.C. The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene 23, 4308–4314 (2004).",{"doi":4866},"10.1038\u002Fsj.onc.1207130",{"id":4868,"createTime":4869,"updateTime":4869,"relativeEntities":4870,"slug":4871,"properties":4872,"entityType":854,"verifyStatus":25,"verifyTime":4869,"verifyNote":855,"syncStatus":28,"languages":4885,"translateLanguages":26,"viewCount":36,"primaryUrl":4886,"fullTextUrl":26,"authors":4887,"publicationType":918,"publisherRelationship":4909,"citationCount":4945,"citationInfo":4946,"publishDate":970,"publishYear":971,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":4956,"isForceReanalyzing":1501},"689b9c87-b1f3-4bec-82ea-f2c9f4c461ac","2024-10-04T07:45:29.923+00:00",[],"Angiogenesis-in-health-and-disease",{"mag":4873,"keywords":4875,"openalex":4876,"abstract":4878,"title":4879,"pm":4881,"doi":4883},{"VOID":4874},"1995827857",{},{"VOID":4877},"W1995827857",{},{"EN":4880},"Angiogenesis in health and disease",{"VOID":4882},"12778163",{"VOID":4884},"10.1038\u002Fnm0603-653",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm0603-653",[4888],{"id":4889,"sortIndex":36,"researcher":26,"roles":4890,"affiliations":4891,"properties":4902},"cf47d90f-0724-4029-8530-cc92e4779458",[],[4892],{"id":4893,"sortIndex":36,"affiliation":4894,"properties":26},"23149da7-7ff1-4f71-ba93-cc82e2d655ee",{"id":4895,"createTime":4896,"updateTime":4896,"relativeEntities":4897,"slug":4898,"properties":4899,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a4dfc5f6-783c-4562-a81e-9f2561196c7b","2024-10-04T07:45:29.939+00:00",[],"Center-for-Transgene-Technology-and-Gene-Therapy-Flanders-Interuniversitary-Institute-for-Biotechnology-KULeuven-Campus-Gasthuisberg-Leuven-Belgium",{"title":4900},{"EN":4901},"Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Leuven, Belgium",{"openalex":4903,"orcid":4905,"title":4907},{"VOID":4904},"A5047152113",{"VOID":4906},"https:\u002F\u002Forcid.org\u002F0000-0001-7961-1821",{"EN":4908},"Peter Carmeliet",{"url":26,"publisher":4910,"properties":4940},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":4911,"slug":663,"properties":4912,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":4918,"manageAffiliations":4919,"indexDatabases":4920,"url":755,"thumbnailPath":26,"statistic":4935,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":4913,"issn":4914,"introduce":4915,"eissn":4916,"title":4917},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[4921,4928],{"id":736,"indexDatabase":4922,"url":749,"indexYears":750,"academicFieldIds":4927,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":4923,"label":4924,"description":4925,"key":746,"publicationTags":4926,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":4929,"url":730,"indexYears":26,"academicFieldIds":4934,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":4930,"label":4931,"description":4932,"key":726,"publicationTags":4933,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":4936,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":4937,"totalCitation":772,"totalCitationByYear":4938,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":4939,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":4941,"pages":4942,"issue":4944},{"VOID":952},{"VOID":4943},"653-660",{"VOID":956},4096,{"total":4945,"publishYear":26,"statisticByYear":4947},{"2012":3223,"2013":4404,"2014":4948,"2015":4949,"2016":3511,"2017":4950,"2018":4950,"2019":4951,"2020":4952,"2021":4953,"2022":4954,"2023":4955,"2024":359},213,201,183,165,161,153,127,116,[4957,4961,4965,4969,4973,4977,4981,4985,4989,4992,4995,4998,5001,5005,5009,5013,5017,5021,5025,5029,5033,5037,5041,5045,5049,5051,5055,5059,5063,5067,5071,5075,5079,5083,5087,5091,5094,5096,5098,5102,5104,5108,5112,5116,5120,5124,5128,5132,5136,5140,5144,5148,5152,5156,5160,5164,5168,5171,5175,5179,5183,5187,5190,5193,5197,5201,5205,5209,5213,5217,5221,5225,5229,5233,5237,5241,5245,5249,5253,5257,5261,5265,5269,5273,5277,5281,5285,5289,5293,5296,5300,5304,5308,5312,5316,5320,5323,5327,5331,5335,5339,5343,5347,5349,5351,5354,5358,5362,5366,5369,5373,5377,5381,5384,5388,5392,5396,5400,5404,5408,5412,5416,5420,5424,5428,5432,5434,5438,5440,5444,5448,5452],{"id":26,"text":4958,"url":26,"identifiers":4959},"Luttun, A., Carmeliet, G. & Carmeliet, P. Vascular progenitors: from biology to treatment. Trends Cardiovasc. Med. 12, 88–96 (2002).",{"doi":4960},"10.1016\u002FS1050-1738(01)00152-9",{"id":26,"text":4962,"url":26,"identifiers":4963},"Rafii, S., Lyden, D., Benezra, R., Hattori, K. & Heissig, B. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat. Rev. Cancer 2, 826–835 (2002).",{"doi":4964},"10.1038\u002Fnrc925",{"id":26,"text":4966,"url":26,"identifiers":4967},"Asahara, T. & Isner, J.M. Endothelial progenitor cells for vascular regeneration. J. Hematother. Stem Cell Res. 11, 171–178 (2002).",{"doi":4968},"10.1089\u002F152581602753658385",{"id":26,"text":4970,"url":26,"identifiers":4971},"Mikkola, H.K. & Orkin, S.H. The search for the hemangioblast. J. Hematother. Stem Cell Res. 11, 9–17 (2002).",{"doi":4972},"10.1089\u002F152581602753448504",{"id":26,"text":4974,"url":26,"identifiers":4975},"Reyes, M. et al. Origin of endothelial progenitors in human postnatal bone marrow. J. Clin. Invest. 109, 337–346 (2002).",{"doi":4976},"10.1172\u002FJCI0214327",{"id":26,"text":4978,"url":26,"identifiers":4979},"Rehman, J., Li, J., Orschell, C.M. & March, K.L. Peripheral blood “endothelial progenitor cells” are derived from monocyte\u002Fmacrophages and secrete angiogenic growth factors. Circulation 107, 1164–1169 (2003).",{"doi":4980},"10.1161\u002F01.CIR.0000058702.69484.A0",{"id":26,"text":4982,"url":26,"identifiers":4983},"Takakura, N. et al. A role for hematopoietic stem cells in promoting angiogenesis. Cell 102, 199–209 (2000).",{"doi":4984},"10.1016\u002FS0092-8674(00)00025-8",{"id":26,"text":4986,"url":26,"identifiers":4987},"Grant, M.B. et al. Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization. Nat. Med. 8, 607–612 (2002).",{"doi":4988},"10.1038\u002Fnm0602-607",{"id":26,"text":4990,"url":26,"identifiers":4991},"Gerber, H.P. et al. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417, 954–958 (2002).",{"doi":1063},{"id":26,"text":4993,"url":26,"identifiers":4994},"Hattori, K. et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment. Nat. Med. 8, 841–849 (2002).",{"doi":1226},{"id":26,"text":4996,"url":26,"identifiers":4997},"Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7, 1194–1201 (2001).",{"doi":2799},{"id":26,"text":4999,"url":26,"identifiers":5000},"Luttun, A. et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8, 831–840 (2002).",{"doi":1230},{"id":26,"text":5002,"url":26,"identifiers":5003},"Rafii, S. & Lyden, D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat. Med. 9, 702–712 (2003).",{"doi":5004},"10.1038\u002Fnm0603-702",{"id":26,"text":5006,"url":26,"identifiers":5007},"Carmeliet, P. Developmental biology. One cell, two fates. Nature 408, 43–45 (2000).",{"doi":5008},"10.1038\u002F35040684",{"id":26,"text":5010,"url":26,"identifiers":5011},"Lawson, N.D. et al. Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development 128, 3675–3683 (2001).",{"doi":5012},"10.1242\u002Fdev.128.19.3675",{"id":26,"text":5014,"url":26,"identifiers":5015},"Zhong, T.P., Childs, S., Leu, J.P. & Fishman, M.C. Gridlock signalling pathway fashions the first embryonic artery. Nature 414, 216–220 (2001).",{"doi":5016},"10.1038\u002F35102599",{"id":26,"text":5018,"url":26,"identifiers":5019},"Lawson, N.D., Vogel, A.M. & Weinstein, B.M. Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev. Cell 3, 127–136 (2002).",{"doi":5020},"10.1016\u002FS1534-5807(02)00198-3",{"id":26,"text":5022,"url":26,"identifiers":5023},"Stalmans, I. et al. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J. Clin. Invest. 109, 327–336 (2002).",{"doi":5024},"10.1172\u002FJCI0214362",{"id":26,"text":5026,"url":26,"identifiers":5027},"Visconti, R.P., Richardson, C.D. & Sato, T.N. Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc. Natl. Acad. Sci. USA 99, 8219–8224 (2002).",{"doi":5028},"10.1073\u002Fpnas.122109599",{"id":26,"text":5030,"url":26,"identifiers":5031},"Kalimo, H., Ruchoux, M.M., Viitanen, M. & Kalaria, R.N. CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia. Brain Pathol. 12, 371–384 (2002).",{"doi":5032},"10.1111\u002Fj.1750-3639.2002.tb00451.x",{"id":26,"text":5034,"url":26,"identifiers":5035},"Mukouyama, Y.S., Shin, D., Britsch, S., Taniguchi, M. & Anderson, D.J. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 109, 693–705 (2002).",{"doi":5036},"10.1016\u002FS0092-8674(02)00757-2",{"id":26,"text":5038,"url":26,"identifiers":5039},"Cleaver, O. & Melton, D.A. Endothelial signaling during development. Nat. Med. 9, ′–′ (2003).",{"doi":5040},"10.1038\u002Fnm0603-661",{"id":26,"text":5042,"url":26,"identifiers":5043},"Jain, R.K. & Munn, L.L. Leaky vessels? Call Ang1! Nat. Med. 6, 131–132 (2000).",{"doi":5044},"10.1038\u002F72212",{"id":26,"text":5046,"url":26,"identifiers":5047},"Suri, C. et al. Increased vascularization in mice overexpressing angiopoietin-1. Science 282, 468–471 (1998).",{"doi":5048},"10.1126\u002Fscience.282.5388.468",{"id":26,"text":1340,"url":26,"identifiers":5050},{"doi":1342},{"id":26,"text":5052,"url":26,"identifiers":5053},"Ruoslahti, E. Drug targeting to specific vascular sites. Drug Discov. Today 7, 1138–1143 (2002).",{"doi":5054},"10.1016\u002FS1359-6446(02)02501-1",{"id":26,"text":5056,"url":26,"identifiers":5057},"Sood, A.K., Fletcher, M.S. & Hendrix, M.J. The embryonic-like properties of aggressive human tumor cells. J. Soc. Gynecol. Investig. 9, 2–9 (2002).",{"doi":5058},"10.1177\u002F107155760200900102",{"id":26,"text":5060,"url":26,"identifiers":5061},"Wang, H.U., Chen, Z.F. & Anderson, D.J. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93, 741–753 (1998).",{"doi":5062},"10.1016\u002FS0092-8674(00)81436-1",{"id":26,"text":5064,"url":26,"identifiers":5065},"Gerety, S.S., Wang, H.U., Chen, Z.F. & Anderson, D.J. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol. Cell 4, 403–414 (1999).",{"doi":5066},"10.1016\u002FS1097-2765(00)80342-1",{"id":26,"text":5068,"url":26,"identifiers":5069},"Zhang, X.Q. et al. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. Blood 98, 1028–1037 (2001).",{"doi":5070},"10.1182\u002Fblood.V98.4.1028",{"id":26,"text":5072,"url":26,"identifiers":5073},"Gale, N.W. et al. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev. Biol. 230, 151–160 (2001).",{"doi":5074},"10.1006\u002Fdbio.2000.0112",{"id":26,"text":5076,"url":26,"identifiers":5077},"Shin, D. et al. Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev. Biol. 230, 139–150 (2001).",{"doi":5078},"10.1006\u002Fdbio.2000.9957",{"id":26,"text":5080,"url":26,"identifiers":5081},"Stalmans, I. et al. VEGF: A modifier of the del22q11 (DiGeorge) syndrome? Nat. Med. 9, 173–182 (2003).",{"doi":5082},"10.1038\u002Fnm819",{"id":26,"text":5084,"url":26,"identifiers":5085},"Loughna, S. & Sato, T.N. A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis. Mol. Cell 7, 233–239 (2001).",{"doi":5086},"10.1016\u002FS1097-2765(01)00171-X",{"id":26,"text":5088,"url":26,"identifiers":5089},"Pugh, C.W. & Ratcliffe, P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9, 677–684 (2003).",{"doi":5090},"10.1038\u002Fnm0603-677",{"id":26,"text":5092,"url":26,"identifiers":5093},"Ferrara, N., Gerber, H.-P., LeCouter, J. & Lin, R. The biology of VEGF and its receptors. Nat. Med. 9, 669–676 (2003).",{"doi":853},{"id":26,"text":1283,"url":26,"identifiers":5095},{"doi":1285},{"id":26,"text":1287,"url":26,"identifiers":5097},{"doi":1289},{"id":26,"text":5099,"url":26,"identifiers":5100},"Oosthuyse, B. et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet. 28, 131–138 (2001).",{"doi":5101},"10.1038\u002F88842",{"id":26,"text":1192,"url":26,"identifiers":5103},{"doi":1194},{"id":26,"text":5105,"url":26,"identifiers":5106},"Carmeliet, P. et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98, 147–157 (1999).",{"doi":5107},"10.1016\u002FS0092-8674(00)81010-7",{"id":26,"text":5109,"url":26,"identifiers":5110},"Corada, M. et al. A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Blood 100, 905–911 (2002).",{"doi":5111},"10.1182\u002Fblood.V100.3.905",{"id":26,"text":5113,"url":26,"identifiers":5114},"Thurston, G. et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat. Med. 6, 460–463 (2000).",{"doi":5115},"10.1038\u002F74725",{"id":26,"text":5117,"url":26,"identifiers":5118},"Simon, A.M. & McWhorter, A.R. Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40. Dev. Biol. 251, 206–220 (2002).",{"doi":5119},"10.1006\u002Fdbio.2002.0826",{"id":26,"text":5121,"url":26,"identifiers":5122},"Hangai, M. et al. Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am. J. Pathol. 161, 1429–1437 (2002).",{"doi":5123},"10.1016\u002FS0002-9440(10)64418-5",{"id":26,"text":5125,"url":26,"identifiers":5126},"Hynes, R.O. A reevaluation of integrins as regulators of angiogenesis. Nat. Med. 8, 918–921 (2002).",{"doi":5127},"10.1038\u002Fnm0902-918",{"id":26,"text":5129,"url":26,"identifiers":5130},"Hood, J.D. & Cheresh, D.A. Role of integrins in cell invasion and migration. Nat. Rev. Cancer 2, 91–100 (2002).",{"doi":5131},"10.1038\u002Fnrc727",{"id":26,"text":5133,"url":26,"identifiers":5134},"Pepper, M.S. Extracellular proteolysis and angiogenesis. Thromb. Haemost. 86, 346–355 (2001).",{"doi":5135},"10.1055\u002Fs-0037-1616232",{"id":26,"text":5137,"url":26,"identifiers":5138},"Jackson, C. Matrix metalloproteinases and angiogenesis. Curr. Opin. Nephrol. Hypertens. 11, 295–299 (2002).",{"doi":5139},"10.1097\u002F00041552-200205000-00005",{"id":26,"text":5141,"url":26,"identifiers":5142},"Luttun, A., Dewerchin, M., Collen, D. & Carmeliet, P. The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: insights from genetic studies. Curr. Atheroscler. Rep. 2, 407–416 (2000).",{"doi":5143},"10.1007\u002Fs11883-000-0079-z",{"id":26,"text":5145,"url":26,"identifiers":5146},"Qi, J.H. et al. A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nat. Med. 9, 407–415 (2003).",{"doi":5147},"10.1038\u002Fnm846",{"id":26,"text":5149,"url":26,"identifiers":5150},"Blasi, F. & Carmeliet, P. uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell Biol. 3, 932–943 (2002).",{"doi":5151},"10.1038\u002Fnrm977",{"id":26,"text":5153,"url":26,"identifiers":5154},"Bajou, K. et al. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat. Med. 4, 923–928 (1998).",{"doi":5155},"10.1038\u002Fnm0898-923",{"id":26,"text":5157,"url":26,"identifiers":5158},"Jain, R.K. Molecular regulation of vessel maturation. Nat. Med. 9, 685–693 (2003).",{"doi":5159},"10.1038\u002Fnm0603-685",{"id":26,"text":5161,"url":26,"identifiers":5162},"Hellstrom, M. et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J. Cell Biol. 153, 543–553 (2001).",{"doi":5163},"10.1083\u002Fjcb.153.3.543",{"id":26,"text":5165,"url":26,"identifiers":5166},"Abramsson, A. et al. Analysis of mural cell recruitment to tumor vessels. Circulation 105, 112–117 (2002).",{"doi":5167},"10.1161\u002Fhc0102.101437",{"id":26,"text":5169,"url":26,"identifiers":5170},"Dinehart, S.M., Kincannon, J. & Geronemus, R. Hemangiomas: evaluation and treatment. Dermatol. Surg. 27, 475–485 (2001).",{},{"id":26,"text":5172,"url":26,"identifiers":5173},"Richardson, T.P., Peters, M.C., Ennett, A.B. & Mooney, D.J. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19, 1029–1034 (2001).",{"doi":5174},"10.1038\u002Fnbt1101-1029",{"id":26,"text":5176,"url":26,"identifiers":5177},"Cao, R. et al. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors. FASEB J. 16, 1575–1583 (2002).",{"doi":5178},"10.1096\u002Ffj.02-0319com",{"id":26,"text":5180,"url":26,"identifiers":5181},"Takagi, H. et al. Potential role of the angiopoietin\u002Ftie2 system in ischemia-induced retinal neovascularization. Invest. Ophthal. Mol. Vis. Sci. 44, 393–402 (2003).",{"doi":5182},"10.1167\u002Fiovs.02-0276",{"id":26,"text":5184,"url":26,"identifiers":5185},"Shim, W.S. et al. Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. Exp. Cell Res. 279, 299–309 (2002).",{"doi":5186},"10.1006\u002Fexcr.2002.5597",{"id":26,"text":5188,"url":26,"identifiers":5189},"Hattori, K. et al. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J. Exp. Med. 193, 1005–1014 (2001).",{"doi":1059},{"id":26,"text":5191,"url":26,"identifiers":5192},"Ahmad, S.A. et al. The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. Cancer Res. 61, 1255–1259 (2001).",{},{"id":26,"text":5194,"url":26,"identifiers":5195},"Carlson, T.R., Feng, Y., Maisonpierre, P.C., Mrksich, M. & Morla, A.O. Direct cell adhesion to the angiopoietins mediated by integrins. J. Biol. Chem. 276, 26516–26525 (2001).",{"doi":5196},"10.1074\u002Fjbc.M100282200",{"id":26,"text":5198,"url":26,"identifiers":5199},"Gale, N.W. et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev. Cell 3, 411–23 (2002).",{"doi":5200},"10.1016\u002FS1534-5807(02)00217-4",{"id":26,"text":5202,"url":26,"identifiers":5203},"Maisonpierre, P.C. et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55–60 (1997).",{"doi":5204},"10.1126\u002Fscience.277.5322.55",{"id":26,"text":5206,"url":26,"identifiers":5207},"Hackett, S.F., Wiegand, S., Yancopoulos, G. & Campochiaro, P.A. Angiopoietin-2 plays an important role in retinal angiogenesis. J. Cell. Physiol. 192, 182–187 (2002).",{"doi":5208},"10.1002\u002Fjcp.10128",{"id":26,"text":5210,"url":26,"identifiers":5211},"Vikkula, M. et al. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 87, 1181–1190 (1996).",{"doi":5212},"10.1016\u002FS0092-8674(00)81814-0",{"id":26,"text":5214,"url":26,"identifiers":5215},"van den Driesche, S., Mummery, C.L. & Westermann, C.J. Hereditary hemorrhagic telangiectasia: an update on transforming growth factor β signaling in vasculogenesis and angiogenesis. Cardiovasc. Res. 58, 20–31 (2003).",{"doi":5216},"10.1016\u002FS0008-6363(02)00852-0",{"id":26,"text":5218,"url":26,"identifiers":5219},"Lamouille, S., Mallet, C., Feige, J.J. & Bailly, S. Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood 100, 4495–4501 (2002).",{"doi":5220},"10.1182\u002Fblood.V100.13.4495",{"id":26,"text":5222,"url":26,"identifiers":5223},"Goumans, M.J. et al. Balancing the activation state of the endothelium via two distinct TGF-β type I receptors. EMBO J. 21, 1743–1753 (2002).",{"doi":5224},"10.1093\u002Femboj\u002F21.7.1743",{"id":26,"text":5226,"url":26,"identifiers":5227},"Srinivasan, S. et al. A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. Hum. Mol. Genet. 12, 473–482 (2003).",{"doi":5228},"10.1093\u002Fhmg\u002Fddg050",{"id":26,"text":5230,"url":26,"identifiers":5231},"Humbert, M. & Trembath, R.C. Genetics of pulmonary hypertension: from bench to bedside. Eur. Respir. J. 20, 741–749 (2002).",{"doi":5232},"10.1183\u002F09031936.02.02702002",{"id":26,"text":5234,"url":26,"identifiers":5235},"Du, L. et al. Signaling molecules in nonfamilial pulmonary hypertension. N. Engl. J. Med. 348, 500–509 (2003).",{"doi":5236},"10.1056\u002FNEJMoa021650",{"id":26,"text":5238,"url":26,"identifiers":5239},"Voelkel, N.F. et al. Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension. Crit. Care Med. 30, S251–S256 (2002).",{"doi":5240},"10.1097\u002F00003246-200205001-00013",{"id":26,"text":5242,"url":26,"identifiers":5243},"Yeager, M.E., Halley, G.R., Golpon, H.A., Voelkel, N.F. & Tuder, R.M. Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension. Circ. Res. 88, E2–E11 (2001).",{"doi":5244},"10.1161\u002F01.RES.88.1.e2",{"id":26,"text":5246,"url":26,"identifiers":5247},"Helisch, A. & Schaper, W. Arteriogenesis: the development and growth of collateral arteries. Microcirculation 10, 83–97 (2003).",{"doi":5248},"10.1080\u002Fmic.10.1.83.97",{"id":26,"text":5250,"url":26,"identifiers":5251},"Kamihata, H. et al. Improvement of collateral perfusion and regional function by implantation of peripheral blood mononuclear cells into ischemic hibernating myocardium. Arterioscler. Thromb. Vasc. Biol. 22, 1804–1810 (2002).",{"doi":5252},"10.1161\u002F01.ATV.0000039168.95670.B9",{"id":26,"text":5254,"url":26,"identifiers":5255},"Heil, M. et al. Blood monocyte concentration is critical for enhancement of collateral artery growth. Am. J. Physiol. Heart Circ. Physiol. 283, H2411–H2419 (2002).",{"doi":5256},"10.1152\u002Fajpheart.01098.2001",{"id":26,"text":5258,"url":26,"identifiers":5259},"van Royen, N. et al. Exogenous application of transforming growth factor β1 stimulates arteriogenesis in the peripheral circulation. FASEB J. 16, 432–434 (2002).",{"doi":5260},"10.1096\u002Ffj.01-0563fje",{"id":26,"text":5262,"url":26,"identifiers":5263},"Buschmann, I.R. et al. GM-CSF: a strong arteriogenic factor acting by amplification of monocyte function. Atherosclerosis 159, 343–356 (2001).",{"doi":5264},"10.1016\u002FS0021-9150(01)00637-2",{"id":26,"text":5266,"url":26,"identifiers":5267},"Voskuil, M. et al. Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1. Am. J. Physiol. Heart Circ. Physiol. 284, H1422–H1428 (2003).",{"doi":5268},"10.1152\u002Fajpheart.00506.2002",{"id":26,"text":5270,"url":26,"identifiers":5271},"Hoefer, I.E. et al. Direct evidence for tumor necrosis factor-α signaling in arteriogenesis. Circulation 105, 1639–1641 (2002).",{"doi":5272},"10.1161\u002F01.CIR.0000014987.32865.8E",{"id":26,"text":5274,"url":26,"identifiers":5275},"Pipp, F. et al. VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism. Circ. Res. 92, 378–385 (2003).",{"doi":5276},"10.1161\u002F01.RES.0000057997.77714.72",{"id":26,"text":5278,"url":26,"identifiers":5279},"Cao, R. et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat. Med. (2003).",{"doi":5280},"10.1038\u002Fnm848",{"id":26,"text":5282,"url":26,"identifiers":5283},"Isner, J.M. Myocardial gene therapy. Nature 415, 234–239 (2002).",{"doi":5284},"10.1038\u002F415234a",{"id":26,"text":5286,"url":26,"identifiers":5287},"Vacca, A. et al. Human lymphoblastoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, and angiogenesis. Int. J. Clin. Lab. Res. 28, 55–68 (1998).",{"doi":5288},"10.1007\u002Fs005990050018",{"id":26,"text":5290,"url":26,"identifiers":5291},"Norrby, K. Mast cells and angiogenesis. APMIS 110, 355–371 (2002).",{"doi":5292},"10.1034\u002Fj.1600-0463.2002.100501.x",{"id":26,"text":5294,"url":26,"identifiers":5295},"Li, X.F. et al. Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J. Clin. Endocrinol. Metab. 86, 1823–1834 (2001).",{},{"id":26,"text":5297,"url":26,"identifiers":5298},"Sica, A., Saccani, A. & Mantovani, A. Tumor-associated macrophages: a molecular perspective. Int. Immunopharmacol. 2, 1045–1054 (2002).",{"doi":5299},"10.1016\u002FS1567-5769(02)00064-4",{"id":26,"text":5301,"url":26,"identifiers":5302},"Coussens, L.M. et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13, 1382–1397 (1999).",{"doi":5303},"10.1101\u002Fgad.13.11.1382",{"id":26,"text":5305,"url":26,"identifiers":5306},"Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998).",{"doi":5307},"10.1038\u002F32588",{"id":26,"text":5309,"url":26,"identifiers":5310},"Schmeisser, A. & Strasser, R.H. Phenotypic overlap between hematopoietic cells with suggested angioblastic potential and vascular endothelial cells. J. Hematother. Stem Cell Res. 11, 69–79 (2002).",{"doi":5311},"10.1089\u002F152581602753448540",{"id":26,"text":5313,"url":26,"identifiers":5314},"Nykanen, A.I. et al. Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis. Circulation 107, 1308–1314 (2003).",{"doi":5315},"10.1161\u002F01.CIR.0000054623.35669.3F",{"id":26,"text":5317,"url":26,"identifiers":5318},"Melder, R.J. et al. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat. Med. 2, 992–997 (1996).",{"doi":5319},"10.1038\u002Fnm0996-992",{"id":26,"text":5321,"url":26,"identifiers":5322},"Carbone, J.E. & Ohm, D.P. Immune dysfunction in cancer patients. Oncology (Huntington) 16, 11–18 (2002).",{},{"id":26,"text":5324,"url":26,"identifiers":5325},"Dermond, O. & Ruegg, C. Inhibition of tumor angiogenesis by non-steroidal anti-inflammatory drugs: emerging mechanisms and therapeutic perspectives. Drug Resist. Update 4, 314–321 (2001).",{"doi":5326},"10.1054\u002Fdrup.2001.0219",{"id":26,"text":5328,"url":26,"identifiers":5329},"Bernardini, G. et al. Analysis of the role of chemokines in angiogenesis. J. Immunol. Meth. 273, 83–101 (2003).",{"doi":5330},"10.1016\u002FS0022-1759(02)00420-9",{"id":26,"text":5332,"url":26,"identifiers":5333},"Trikha, M. & Nakada, M.T. Platelets and cancer: implications for antiangiogenic therapy. Semin. Thromb. Hemost. 28, 39–44 (2002).",{"doi":5334},"10.1055\u002Fs-2002-20563",{"id":26,"text":5336,"url":26,"identifiers":5337},"Carmeliet, P. Biomedicine. Clotting factors build blood vessels. Science 293, 1602–1604 (2001).",{"doi":5338},"10.1126\u002Fscience.1064981",{"id":26,"text":5340,"url":26,"identifiers":5341},"Fernandez, P.M. & Rickles, F.R. Tissue factor and angiogenesis in cancer. Curr. Opin. Hematol. 9, 401–406 (2002).",{"doi":5342},"10.1097\u002F00062752-200209000-00003",{"id":26,"text":5344,"url":26,"identifiers":5345},"English, D., Brindley, D.N., Spiegel, S. & Garcia, J.G. Lipid mediators of angiogenesis and the signalling pathways they initiate. Biochim. Biophys. Acta 1582, 228–239 (2002).",{"doi":5346},"10.1016\u002FS1388-1981(02)00176-2",{"id":26,"text":1033,"url":26,"identifiers":5348},{"doi":1035},{"id":26,"text":1494,"url":26,"identifiers":5350},{"doi":1496},{"id":26,"text":5352,"url":26,"identifiers":5353},"Boudier, H.A. Arteriolar and capillary remodelling in hypertension. Drugs 58 (suppl. 1), 37–40 (1999).",{},{"id":26,"text":5355,"url":26,"identifiers":5356},"Benjamin, L.E., Hemo, I. & Keshet, E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125, 1591–1598 (1998).",{"doi":5357},"10.1242\u002Fdev.125.9.1591",{"id":26,"text":5359,"url":26,"identifiers":5360},"Vailhe, B. & Feige, J.J. Thrombospondins as anti-angiogenic therapeutic agents. Curr. Pharm. Des. 9, 583–588 (2003).",{"doi":5361},"10.2174\u002F1381612033391342",{"id":26,"text":5363,"url":26,"identifiers":5364},"Holash, J. et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284, 1994–1998 (1999).",{"doi":5365},"10.1126\u002Fscience.284.5422.1994",{"id":26,"text":5367,"url":26,"identifiers":5368},"Schonfeld, C.L. Hyalocytes inhibit retinal pigment epithelium cell proliferation in vitro. Ger. J. Ophthalmol. 5, 224–228 (1996).",{},{"id":26,"text":5370,"url":26,"identifiers":5371},"Makino, Y., Kanopka, A., Wilson, W.J., Tanaka, H. & Poellinger, L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus. J. Biol. Chem. 277, 32405–32408 (2002).",{"doi":5372},"10.1074\u002Fjbc.C200328200",{"id":26,"text":5374,"url":26,"identifiers":5375},"D'Amore, P.A. & Ng, Y.S. Tales of the cryptic: unveiling more angiogenesis inhibitors. Trends Mol. Med. 8, 313–315 (2002).",{"doi":5376},"10.1016\u002FS1471-4914(02)02367-5",{"id":26,"text":5378,"url":26,"identifiers":5379},"Meyer, M. et al. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J. 18, 363–374 (1999).",{"doi":5380},"10.1093\u002Femboj\u002F18.2.363",{"id":26,"text":5382,"url":26,"identifiers":5383},"Harada, K., Lu, S., Chisholm, D.M., Syrjanen, S. & Schor, A.M. Angiogenesis and vasodilation in skin warts. Association with HPV infection. Anticancer Res. 20, 4519–4523 (2000).",{},{"id":26,"text":5385,"url":26,"identifiers":5386},"Barillari, G. & Ensoli, B. Angiogenic effects of extracellular human immunodeficiency virus type 1 Tat protein and its role in the pathogenesis of AIDS-associated Kaposi's sarcoma. Clin. Microbiol. Rev. 15, 310–326 (2002).",{"doi":5387},"10.1128\u002FCMR.15.2.310-326.2002",{"id":26,"text":5389,"url":26,"identifiers":5390},"Rupnick, M.A. et al. Adipose tissue mass can be regulated through the vasculature. Proc. Natl. Acad. Sci. USA 99, 10730–10735 (2002).",{"doi":5391},"10.1073\u002Fpnas.162349799",{"id":26,"text":5393,"url":26,"identifiers":5394},"Hackett, S.F. et al. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J. Cell Physiol. 184, 275–284 (2000).",{"doi":5395},"10.1002\u002F1097-4652(200009)184:3\u003C275::AID-JCP1>3.0.CO;2-7",{"id":26,"text":5397,"url":26,"identifiers":5398},"De La Torre, J.C. Alzheimer's disease: How does it start? J. Alzheimers Dis. 4, 497–512 (2002).",{"doi":5399},"10.3233\u002FJAD-2002-4606",{"id":26,"text":5401,"url":26,"identifiers":5402},"Krupinski, J., Kaluza, J., Kumar, P., Kumar, S. & Wang, J.M. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25, 1794–1798 (1994).",{"doi":5403},"10.1161\u002F01.STR.25.9.1794",{"id":26,"text":5405,"url":26,"identifiers":5406},"Van Belle, E. et al. Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Circulation 96, 2667–2674 (1997).",{"doi":5407},"10.1161\u002F01.CIR.96.8.2667",{"id":26,"text":5409,"url":26,"identifiers":5410},"Waltenberger, J. Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications. Cardiovasc. Res. 49, 554–560 (2001).",{"doi":5411},"10.1016\u002FS0008-6363(00)00228-5",{"id":26,"text":5413,"url":26,"identifiers":5414},"Rivard, A. et al. Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. Am. J. Pathol. 154, 355–363 (1999).",{"doi":5415},"10.1016\u002FS0002-9440(10)65282-0",{"id":26,"text":5417,"url":26,"identifiers":5418},"Gennaro, G., Menard, C., Michaud, S.E. & Rivard, A. Age-dependent impairment of reendothelialization after arterial injury: role of vascular endothelial growth factor. Circulation 107, 230–233 (2003).",{"doi":5419},"10.1161\u002F01.CIR.0000050652.47145.4C",{"id":26,"text":5421,"url":26,"identifiers":5422},"Jenkinson, L., Bardhan, K.D., Atherton, J. & Kalia, N. Helicobacter pylori prevents proliferative stage of angiogenesis in vitro: role of cytokines. Dig. Dis. Sci. 47, 1857–1862 (2002).",{"doi":5423},"10.1023\u002FA:1016469217449",{"id":26,"text":5425,"url":26,"identifiers":5426},"Yano, K., Brown, L.F. & Detmar, M. Control of hair growth and follicle size by VEGF-mediated angiogenesis. J. Clin. Invest. 107, 409–417 (2001).",{"doi":5427},"10.1172\u002FJCI11317",{"id":26,"text":5429,"url":26,"identifiers":5430},"Chang, E., Yang, J., Nagavarapu, U. & Herron, G.S. Aging and survival of cutaneous microvasculature. J. Invest. Dermatol. 118, 752–758 (2002).",{"doi":5431},"10.1046\u002Fj.1523-1747.2002.01714.x",{"id":26,"text":1478,"url":26,"identifiers":5433},{"doi":1480},{"id":26,"text":5435,"url":26,"identifiers":5436},"Hewett, P. et al. Down-regulation of angiopoietin-1 expression in menorrhagia. Am. J. Pathol. 160, 773–780 (2002).",{"doi":5437},"10.1016\u002FS0002-9440(10)64899-7",{"id":26,"text":1021,"url":26,"identifiers":5439},{"doi":1023},{"id":26,"text":5441,"url":26,"identifiers":5442},"Kasahara, Y. et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106, 1311–1319 (2000).",{"doi":5443},"10.1172\u002FJCI10259",{"id":26,"text":5445,"url":26,"identifiers":5446},"Kang, D.H. et al. Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease. Am. J. Kidney Dis. 37, 601–611 (2001).",{"doi":5447},"10.1053\u002Fajkd.2001.22087",{"id":26,"text":5449,"url":26,"identifiers":5450},"Martinez, P., Esbrit, P., Rodrigo, A., Alvarez-Arroyo, M.V. & Martinez, M.E. Age-related changes in parathyroid hormone-related protein and vascular endothelial growth factor in human osteoblastic cells. Osteoporos. Int. 13, 874–881 (2002).",{"doi":5451},"10.1007\u002Fs001980200120",{"id":26,"text":5453,"url":26,"identifiers":5454},"Yin, G. et al. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis. Mol. Ther. 5, 547–554 (2002).",{"doi":5455},"10.1006\u002Fmthe.2002.0590",{"id":5457,"createTime":5458,"updateTime":5458,"relativeEntities":5459,"slug":5460,"properties":5461,"entityType":854,"verifyStatus":25,"verifyTime":5458,"verifyNote":855,"syncStatus":28,"languages":5474,"translateLanguages":26,"viewCount":36,"primaryUrl":5475,"fullTextUrl":26,"authors":5476,"publicationType":918,"publisherRelationship":5709,"citationCount":5745,"citationInfo":5746,"publishDate":5756,"publishYear":5757,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":5758,"isForceReanalyzing":1501},"9a950b3e-ef63-4f7d-99c8-0959f0ce8f01","2024-07-18T13:06:26.484+00:00",[],"Tumor-associated-B7-H1-promotes-T-cell-apoptosis-A-potential-mechanism-of-immune-evasion",{"mag":5462,"keywords":5464,"openalex":5465,"abstract":5467,"title":5468,"pm":5470,"doi":5472},{"VOID":5463},"2016983859",{},{"VOID":5466},"W2016983859",{},{"EN":5469},"Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion",{"VOID":5471},"12091876",{"VOID":5473},"10.1038\u002Fnm730",[102],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnm730",[5477,5499,5521,5536,5553,5570,5587,5609,5624,5641,5658,5675,5692],{"id":5478,"sortIndex":158,"researcher":26,"roles":5479,"affiliations":5480,"properties":5492},"d98861b1-8547-495d-90d9-59df5b3bf7d8",[],[5481],{"id":5482,"sortIndex":36,"affiliation":5483,"properties":26},"c976de37-a774-4805-a890-f0b1cca3430a",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5487,"slug":5488,"properties":5489,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a696c723-3328-4561-8458-51dabe9fe9e8","2024-01-13T03:21:35.050+00:00","2024-07-18T13:06:26.506+00:00",[],"Department-of-Immunology-Mayo-Clinic-Rochester-Minnesota-USA",{"title":5490},{"VI":5491},"Department of Immunology, Mayo Clinic, Rochester, Minnesota USA",{"openalex":5493,"orcid":5495,"title":5497},{"VOID":5494},"A5009882164",{"VOID":5496},"https:\u002F\u002Forcid.org\u002F0000-0003-2726-7613",{"EN":5498},"Jun Lü",{"id":5500,"sortIndex":114,"researcher":26,"roles":5501,"affiliations":5502,"properties":5514},"172acebf-22d3-496a-a2d3-20f9e0c9a71d",[],[5503],{"id":5504,"sortIndex":36,"affiliation":5505,"properties":26},"01461f38-587d-4830-940c-cd35599ca771",{"id":5506,"createTime":5507,"updateTime":5508,"relativeEntities":5509,"slug":5510,"properties":5511,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"6604a4c0-28e1-4789-9304-3c307ffc71e6","2024-01-16T21:13:58.735+00:00","2024-12-21T02:44:12.293+00:00",[],"Department-of-Laboratory-Medicine-and-Pathology-Mayo-Clinic-Rochester-Minnesota-USA",{"title":5512},{"VI":5513},"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA",{"openalex":5515,"orcid":5517,"title":5519},{"VOID":5516},"A5049186993",{"VOID":5518},"https:\u002F\u002Forcid.org\u002F0000-0001-5066-9667",{"EN":5520},"Diva R. Salomão",{"id":5522,"sortIndex":50,"researcher":26,"roles":5523,"affiliations":5524,"properties":5531},"861eb12c-a8e6-486b-85ea-82e37be7a2c6",[],[5525],{"id":5526,"sortIndex":36,"affiliation":5527,"properties":26},"76ca89cb-0db0-40f6-b6e4-b171e93a2b15",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5528,"slug":5488,"properties":5529,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5530},{"VI":5491},{"openalex":5532,"title":5534},{"VOID":5533},"A5102507722",{"EN":5535},"Gefeng Zhu",{"id":5537,"sortIndex":116,"researcher":26,"roles":5538,"affiliations":5539,"properties":5546},"39e62a4b-4bea-4a7b-b6d5-c93f57e9320d",[],[5540],{"id":5541,"sortIndex":36,"affiliation":5542,"properties":26},"f4299e73-51ea-4e80-980c-1f70d68bee31",{"id":5506,"createTime":5507,"updateTime":5508,"relativeEntities":5543,"slug":5510,"properties":5544,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5545},{"VI":5513},{"openalex":5547,"orcid":5549,"title":5551},{"VOID":5548},"A5055122406",{"VOID":5550},"https:\u002F\u002Forcid.org\u002F0000-0003-1910-1576",{"EN":5552},"Vanda A. Lennon",{"id":5554,"sortIndex":59,"researcher":26,"roles":5555,"affiliations":5556,"properties":5563},"990e0934-2c95-4f3b-b243-d64b57ab79b5",[],[5557],{"id":5558,"sortIndex":36,"affiliation":5559,"properties":26},"dfbf09c7-8f39-449b-9f45-0712788fc46b",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5560,"slug":5488,"properties":5561,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5562},{"VI":5491},{"openalex":5564,"orcid":5566,"title":5568},{"VOID":5565},"A5056294010",{"VOID":5567},"https:\u002F\u002Forcid.org\u002F0000-0003-1782-4375",{"EN":5569},"Hideto Tamura",{"id":5571,"sortIndex":52,"researcher":26,"roles":5572,"affiliations":5573,"properties":5580},"fbd8f7b1-6b15-4b90-b37f-a33511596031",[],[5574],{"id":5575,"sortIndex":36,"affiliation":5576,"properties":26},"fe0e71e4-a41c-41a7-a7db-e92d542d90bc",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5577,"slug":5488,"properties":5578,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5579},{"VI":5491},{"openalex":5581,"orcid":5583,"title":5585},{"VOID":5582},"A5002617255",{"VOID":5584},"https:\u002F\u002Forcid.org\u002F0000-0002-3098-2565",{"EN":5586},"Koji Tamada",{"id":5588,"sortIndex":115,"researcher":26,"roles":5589,"affiliations":5590,"properties":5602},"562d549b-4a1c-4b7f-9043-03fdff18c995",[],[5591],{"id":5592,"sortIndex":36,"affiliation":5593,"properties":26},"be54de4f-84d2-4cb4-96f7-12df37ae2ed7",{"id":5594,"createTime":5595,"updateTime":5596,"relativeEntities":5597,"slug":5598,"properties":5599,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d29360eb-1582-4d2e-887c-8a1dc317c2b2","2024-01-18T02:42:47.982+00:00","2024-07-18T13:06:26.520+00:00",[],"Department-of-Otorhinolaryngology-Mayo-Clinic-Rochester-Minnesota-USA",{"title":5600},{"VI":5601},"Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA",{"openalex":5603,"orcid":5605,"title":5607},{"VOID":5604},"A5028801725",{"VOID":5606},"https:\u002F\u002Forcid.org\u002F0000-0003-0927-8722",{"EN":5608},"Scott E. Strome",{"id":5610,"sortIndex":111,"researcher":26,"roles":5611,"affiliations":5612,"properties":5619},"6f187e43-12b5-4c42-857a-497f67005c3d",[],[5613],{"id":5614,"sortIndex":36,"affiliation":5615,"properties":26},"c20d8d2e-7dd1-4d4b-9da9-eda1a36357f2",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5616,"slug":5488,"properties":5617,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5618},{"VI":5491},{"openalex":5620,"title":5622},{"VOID":5621},"A5067166168",{"EN":5623},"Fumiya Hirano",{"id":5625,"sortIndex":53,"researcher":26,"roles":5626,"affiliations":5627,"properties":5634},"475c9bbc-80ed-4f30-916f-2313255c6068",[],[5628],{"id":5629,"sortIndex":36,"affiliation":5630,"properties":26},"4610e6eb-860a-4ec5-8558-aa530320a24f",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5631,"slug":5488,"properties":5632,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5633},{"VI":5491},{"openalex":5635,"orcid":5637,"title":5639},{"VOID":5636},"A5032554768",{"VOID":5638},"https:\u002F\u002Forcid.org\u002F0000-0001-8299-4480",{"EN":5640},"Esteban Celis",{"id":5642,"sortIndex":162,"researcher":26,"roles":5643,"affiliations":5644,"properties":5651},"ea26d251-7b44-4abe-8304-ebe0a3826557",[],[5645],{"id":5646,"sortIndex":36,"affiliation":5647,"properties":26},"202833b6-db83-450f-acf6-6519fdc136ce",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5648,"slug":5488,"properties":5649,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5650},{"VI":5491},{"openalex":5652,"orcid":5654,"title":5656},{"VOID":5653},"A5043413904",{"VOID":5655},"https:\u002F\u002Forcid.org\u002F0000-0002-9280-2080",{"EN":5657},"Dallas B. Flies",{"id":5659,"sortIndex":36,"researcher":26,"roles":5660,"affiliations":5661,"properties":5668},"8c6ed9be-a9fc-4382-ba08-8f8af83df7bd",[],[5662],{"id":5663,"sortIndex":36,"affiliation":5664,"properties":26},"4bf9607b-3204-4ce7-ab19-5dd54ad4e053",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5665,"slug":5488,"properties":5666,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5667},{"VI":5491},{"openalex":5669,"orcid":5671,"title":5673},{"VOID":5670},"A5038413156",{"VOID":5672},"https:\u002F\u002Forcid.org\u002F0000-0002-5782-2983",{"EN":5674},"Haidong Dong",{"id":5676,"sortIndex":103,"researcher":26,"roles":5677,"affiliations":5678,"properties":5685},"31b0e92e-1cee-44fc-9896-bb25f3110df7",[],[5679],{"id":5680,"sortIndex":36,"affiliation":5681,"properties":26},"00197e8a-9a04-4c21-b8dc-1e66f51a8a5e",{"id":5484,"createTime":5485,"updateTime":5486,"relativeEntities":5682,"slug":5488,"properties":5683,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5684},{"VI":5491},{"openalex":5686,"orcid":5688,"title":5690},{"VOID":5687},"A5035295243",{"VOID":5689},"https:\u002F\u002Forcid.org\u002F0000-0002-6825-3069",{"EN":5691},"Lieping Chen",{"id":5693,"sortIndex":135,"researcher":26,"roles":5694,"affiliations":5695,"properties":5702},"e2bffdce-7768-41bb-99ff-b8f5d095637f",[],[5696],{"id":5697,"sortIndex":36,"affiliation":5698,"properties":26},"0730999a-8450-4f5c-b113-8442bbedc7fc",{"id":5506,"createTime":5507,"updateTime":5508,"relativeEntities":5699,"slug":5510,"properties":5700,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":5701},{"VI":5513},{"openalex":5703,"orcid":5705,"title":5707},{"VOID":5704},"A5002612454",{"VOID":5706},"https:\u002F\u002Forcid.org\u002F0000-0002-7441-1756",{"EN":5708},"Patrick C. Roche",{"url":26,"publisher":5710,"properties":5740},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":5711,"slug":663,"properties":5712,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":5718,"manageAffiliations":5719,"indexDatabases":5720,"url":755,"thumbnailPath":26,"statistic":5735,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"country":5713,"issn":5714,"introduce":5715,"eissn":5716,"title":5717},{"VOID":666},{"VOID":668},{"EN":670},{"VOID":672},{"EN":674},[],[],[5721,5728],{"id":736,"indexDatabase":5722,"url":749,"indexYears":750,"academicFieldIds":5727,"indexDatabaseRanking":754},{"id":738,"createTime":739,"updateTime":740,"relativeEntities":5723,"label":5724,"description":5725,"key":746,"publicationTags":5726,"standard":26},[],{"EN":743,"VI":743},{"EN":743,"VI":745},[748],[752,753],{"id":715,"indexDatabase":5729,"url":730,"indexYears":26,"academicFieldIds":5734,"indexDatabaseRanking":26},{"id":717,"createTime":718,"updateTime":719,"relativeEntities":5730,"label":5731,"description":5732,"key":726,"publicationTags":5733,"standard":26},[],{"EN":722,"VI":722},{"VI":724,"EN":725},[728,729],[732,733,734],{"impactFactor":36,"impactFactorByYear":5736,"i10Index":769,"i10IndexLast5Year":244,"totalPublication":770,"totalPublicationByYear":5737,"totalCitation":772,"totalCitationByYear":5738,"totalCitationPerPublication":803,"totalCitationPerPublicationByYear":5739,"hindexLast5Year":831,"hindex":831},{"2012":758,"2013":759,"2014":204,"2015":760,"2016":761,"2017":762,"2018":763,"2019":764,"2020":765,"2021":766,"2022":767,"2023":768},{"1995":116,"1996":52,"1997":336,"1998":52,"1999":51,"2000":356,"2001":103,"2002":124,"2003":53,"2004":116,"2005":53,"2006":356,"2007":158,"2008":53,"2009":52,"2010":158,"2011":356,"2012":356,"2013":158,"2014":103,"2015":116,"2016":115,"2017":115,"2018":53,"2019":135,"2020":103,"2021":158,"2022":59,"2023":115},{"1995":774,"1996":775,"1997":776,"1998":777,"1999":778,"2000":779,"2001":780,"2002":781,"2003":782,"2004":783,"2005":784,"2006":785,"2007":786,"2008":787,"2009":788,"2010":789,"2011":790,"2012":791,"2013":792,"2014":793,"2015":794,"2016":795,"2017":796,"2018":797,"2019":798,"2020":799,"2021":800,"2022":801,"2023":802},{"1995":805,"1996":806,"1997":807,"1998":808,"1999":809,"2000":810,"2001":811,"2002":812,"2003":813,"2004":814,"2005":815,"2006":816,"2007":817,"2008":818,"2009":819,"2010":820,"2011":821,"2012":822,"2013":823,"2014":824,"2015":825,"2016":795,"2017":796,"2018":826,"2019":827,"2020":828,"2021":829,"2022":830,"2023":802},{"volume":5741,"pages":5742,"issue":5744},{"VOID":4144},{"VOID":5743},"793-800",{"VOID":4144},4035,{"total":5745,"publishYear":26,"statisticByYear":5747},{"2012":5748,"2013":127,"2014":5749,"2015":4149,"2016":5750,"2017":5751,"2018":5752,"2019":5753,"2020":968,"2021":5754,"2022":149,"2023":5755,"2024":248},90,131,307,344,393,372,367,251,"2002-08-01",2002,[5759,5763,5767,5771,5775,5779,5783,5787,5791,5795,5799,5803,5807,5811,5815,5819,5823,5826,5830,5834,5838,5841,5845,5849,5853,5857,5861,5865,5869,5873,5876,5880,5884,5888,5892,5896,5900,5903,5906],{"id":26,"text":5760,"url":26,"identifiers":5761},"Chambers, C.A. & Allison, J.P. Co-stimulation in T cell responses. Curr. Opin. Immunol. 9, 396–404 (1997).",{"doi":5762},"10.1016\u002FS0952-7915(97)80087-8",{"id":26,"text":5764,"url":26,"identifiers":5765},"Lenschow, D.J., Walunas, T.L. & Bluestone, J.A. CD28\u002FB7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233–258 (1996).",{"doi":5766},"10.1146\u002Fannurev.immunol.14.1.233",{"id":26,"text":5768,"url":26,"identifiers":5769},"Chen, L., Linsley, P.S. & Hellstrom, K.E. Costimulation of T cells for tumor immunity. Immunol. Today 14, 483–486 (1993).",{"doi":5770},"10.1016\u002F0167-5699(93)90262-J",{"id":26,"text":5772,"url":26,"identifiers":5773},"Boise, L.H., Noel, P.J. & Thompson, C.B. CD28 and apoptosis. Curr. Opin. Immunol. 7, 620–625 (1995).",{"doi":5774},"10.1016\u002F0952-7915(95)80067-0",{"id":26,"text":5776,"url":26,"identifiers":5777},"Watts, T.H. & DeBenedette, M.A. T cell co-stimulatory molecules other than CD28. Curr. Opin. Immunol. 11, 286–293 (1999).",{"doi":5778},"10.1016\u002FS0952-7915(99)80046-6",{"id":26,"text":5780,"url":26,"identifiers":5781},"Noel, P.J., Boise, L.H., Green, J.M. & Thompson, C.B. CD28 costimulation prevents cell death during primary T cell activation. J. Immunol. 157, 636–642 (1996).",{"doi":5782},"10.4049\u002Fjimmunol.157.2.636",{"id":26,"text":5784,"url":26,"identifiers":5785},"Hurtado, J.C., Kim, Y.J. & Kwon, B.S. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. J. Immunol. 158, 2600–2609 (1997).",{"doi":5786},"10.4049\u002Fjimmunol.158.6.2600",{"id":26,"text":5788,"url":26,"identifiers":5789},"Takahashi, C., Mittler, R.S. & Vella, A.T. 4-1BB is a bona fide CD8 T cell survival signal. J. Immunol. 162, 5037–5040 (1999).",{"doi":5790},"10.4049\u002Fjimmunol.162.9.5037",{"id":26,"text":5792,"url":26,"identifiers":5793},"Rogers, P.R., Song, J., Gramaglia, I., Killeen, N. & Croft, M. OX40 promotes bcl-xl and bcl-2 expression and is essential for long-term survival of CD4+ T cells. Immunity 15, 445–455 (2001).",{"doi":5794},"10.1016\u002FS1074-7613(01)00191-1",{"id":26,"text":5796,"url":26,"identifiers":5797},"Krummel, M.F. & Allison, J.P. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183, 2533–2540 (1996).",{"doi":5798},"10.1084\u002Fjem.183.6.2533",{"id":26,"text":5800,"url":26,"identifiers":5801},"Walunas, T.L., Bakker, C.Y. & Bluestone, J.A. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183, 2541–2550 (1996).",{"doi":5802},"10.1084\u002Fjem.183.6.2541",{"id":26,"text":5804,"url":26,"identifiers":5805},"Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Med. 5, 1365–1369 (1999).",{"doi":5806},"10.1038\u002F70932",{"id":26,"text":5808,"url":26,"identifiers":5809},"Tamura, H. et al. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 97, 1809–1816 (2001).",{"doi":5810},"10.1182\u002Fblood.V97.6.1809",{"id":26,"text":5812,"url":26,"identifiers":5813},"Freeman, G.J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027–1034 (2000).",{"doi":5814},"10.1084\u002Fjem.192.7.1027",{"id":26,"text":5816,"url":26,"identifiers":5817},"Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif–carrying immunoreceptor. Immunity 11, 141–151 (1999).",{"doi":5818},"10.1016\u002FS1074-7613(00)80089-8",{"id":26,"text":5820,"url":26,"identifiers":5821},"Nishimura, H. et al. Autoimmune dilated cardiomyopathy in PD-1 receptor–deficient mice. Science 291, 319–322 (2001).",{"doi":5822},"10.1126\u002Fscience.291.5502.319",{"id":26,"text":5824,"url":26,"identifiers":5825},"Rivoltini, L. et al. Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes. Cancer Res. 55, 3149–3157 (1995).",{},{"id":26,"text":5827,"url":26,"identifiers":5828},"Nagata, S. & Golstein, P. The Fas death factor. Science 267, 1449–1456 (1995).",{"doi":5829},"10.1126\u002Fscience.7533326",{"id":26,"text":5831,"url":26,"identifiers":5832},"Jeremias, I., Herr, I., Boehler, T. & Debatin, K.M. TRAIL\u002FApo-2-ligand-induced apoptosis in human T cells. Eur. J. Immunol. 28, 143–152 (1998).",{"doi":5833},"10.1002\u002F(SICI)1521-4141(199801)28:01\u003C143::AID-IMMU143>3.0.CO;2-3",{"id":26,"text":5835,"url":26,"identifiers":5836},"Zhao, S. et al. Functional expression of TRAIL by lymphoid and myeloid tumour cells. Br. J. Haematol. 106, 827–832 (1999).",{"doi":5837},"10.1046\u002Fj.1365-2141.1999.01630.x",{"id":26,"text":5839,"url":26,"identifiers":5840},"Lu, J. & Celis, E. Use of two predictive algorithms of the world wide web for the identification of tumor-reactive T-cell epitopes. Cancer Res. 60, 5223–5227 (2000).",{},{"id":26,"text":5842,"url":26,"identifiers":5843},"Georgescu, L., Vakkalanka, R.K. Elkon, K.B. & Crow, M.K. Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand. J. Clin. Invest. 100, 2622–2633 (1997).",{"doi":5844},"10.1172\u002FJCI119806",{"id":26,"text":5846,"url":26,"identifiers":5847},"Sykulev, Y. et al. High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA 91, 11487–11491 (1994).",{"doi":5848},"10.1073\u002Fpnas.91.24.11487",{"id":26,"text":5850,"url":26,"identifiers":5851},"Tamada, K., Tamura, H., Flies, D.B., Fu, Y.X., Pease, L.R., Blazar, B.R. & Chen, L. Blockade of LIGHT\u002FLTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J. Clin. Invest. 109, 549–557 (2002).",{"doi":5852},"10.1172\u002FJCI0213604",{"id":26,"text":5854,"url":26,"identifiers":5855},"Chen, L., McGowan, P., Ashe, S., Johnston, J., Li, Y., Hellstrom, I. & Hellstrom, K.E. Tumor immunogenicity determines the effect of B7 costimulation on T cell–mediated tumor immunity. J. Exp. Med. 179, 523–532 (1994).",{"doi":5856},"10.1084\u002Fjem.179.2.523",{"id":26,"text":5858,"url":26,"identifiers":5859},"Smyth, M.J., Godfrey, D.I. & Trapani, J.A. A fresh look at tumor immunosurveillance and immunotherapy. Nature Immunol. 2, 293–299 (2001).",{"doi":5860},"10.1038\u002F86297",{"id":26,"text":5862,"url":26,"identifiers":5863},"Griffith, T.S, Brunner, T., Fletcher, S.M., Green, D.R. & Ferguson, T.A. Fas ligand–induced apoptosis as a mechanism of immune privilege. Science 270, 1189–1192 (1995).",{"doi":5864},"10.1126\u002Fscience.270.5239.1189",{"id":26,"text":5866,"url":26,"identifiers":5867},"O'Connell, J., Bennett, M.W., O'Sullivan, G.C., Collins, J.K. & Shanahan, F. Fas counter-attack: the best form of tumor defense? Nature Med. 5, 267–268 (1999).",{"doi":5868},"10.1038\u002F6477",{"id":26,"text":5870,"url":26,"identifiers":5871},"Strand, S. & Galle, P.R. Immune evasion by tumours: involvement of the CD95 (APO-1\u002FFas) system and its clinical implications. Mol. Med. Today 4, 63–68 (1998).",{"doi":5872},"10.1016\u002FS1357-4310(97)01191-X",{"id":26,"text":5874,"url":26,"identifiers":5875},"Chappell, D.B, Zaks, T.Z., Rosenberg, S.A. & Restifo, N.P. Human melanoma cells do not express Fas (Apo-1\u002FCD95) ligand. Cancer Res. 59, 59–62 (1999).",{},{"id":26,"text":5877,"url":26,"identifiers":5878},"Arai, H., Gordon, D., Nabel, E.G. & Nabel, G.J. Gene transfer of Fas ligand induces tumor regression in vivo. Proc. Natl. Acad. Sci. USA. 94, 13862–13867 (1997).",{"doi":5879},"10.1073\u002Fpnas.94.25.13862",{"id":26,"text":5881,"url":26,"identifiers":5882},"Nakashima, M., Sonoda, K. & Watanabe, K. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen, RCAS1. Nature Med. 5, 938–942 (1999).",{"doi":5883},"10.1038\u002F11383",{"id":26,"text":5885,"url":26,"identifiers":5886},"Ishida, Y., Agata, Y., Shibahara, K. & Honjo, T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11, 3887–3895 (1992).",{"doi":5887},"10.1002\u002Fj.1460-2075.1992.tb05481.x",{"id":26,"text":5889,"url":26,"identifiers":5890},"Linsley, P.S., Greene, J.L., Brady, W., Bajorath, J., Ledbetter, J.A. & Peach, R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1, 793–801 (1994).",{"doi":5891},"10.1016\u002FS1074-7613(94)80021-9",{"id":26,"text":5893,"url":26,"identifiers":5894},"Agata, Y. et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765–772 (1996).",{"doi":5895},"10.1093\u002Fintimm\u002F8.5.765",{"id":26,"text":5897,"url":26,"identifiers":5898},"Finger, L.R. et al. G The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors. Gene 197, 177–187 (1997).",{"doi":5899},"10.1016\u002FS0378-1119(97)00260-6",{"id":26,"text":5901,"url":26,"identifiers":5902},"Chapoval, A.I., Zhu, G. & Chen, L. Immunoglobulin fusion protein as a tool for evaluation of T-cell costimulatory molecules. Methods Mol. Med. 45, 247–255 (2000).",{},{"id":26,"text":5904,"url":26,"identifiers":5905},"Kobayashi, H., Wood, M., Song, Y., Appella, E. & Celis, E. Defining promiscuous MHC class II helper T-cell epitopes for the HER2\u002Fneu tumor antigen. Cancer Res. 60, 5228–5236 (2000).",{},{"id":26,"text":5907,"url":26,"identifiers":5908},"Yu, Z., Kryzer, T.J., Griesmann, G.E., Kim, K.K., Benarroch, E., & Lennon, V.A. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann. Neurol. 49, 146–154 (2001).",{"doi":5909},"10.1002\u002F1531-8249(20010201)49:2\u003C146::AID-ANA34>3.0.CO;2-E"]