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Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia. Metabolism \n                           54, 351–360 (2005).",{"doi":707},"10.1016\u002Fj.metabol.2004.09.015",{"id":18,"text":709,"url":18,"identifiers":710},"Wang J. M., Chen A. F., Zhang K. Isolation and primary culture of mouse aortic endothelial cells. J. Vis. Exp. 118, e52965 (2016).",{},{"id":18,"text":712,"url":18,"identifiers":713},"Xu, Y. et al. Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler. Thromb. Vasc. Biol. \n                           34, 1231–1239 (2014).",{"doi":714},"10.1161\u002FATVBAHA.113.303041",{"id":18,"text":716,"url":18,"identifiers":717},"Huo, Y. et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat. 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Previous efforts to form two-dimensional dilute magnetic semiconductors utilized extrinsic doping techniques or bulk crystal growth, detrimentally affecting uniformity, scalability, or Curie temperature. Here, we demonstrate an in situ substitutional doping of Fe atoms into MoS\u003Cjats:sub>2\u003C\u002Fjats:sub> monolayers in the chemical vapor deposition growth. The iron atoms substitute molybdenum sites in MoS\u003Cjats:sub>2\u003C\u002Fjats:sub> crystals, as confirmed by transmission electron microscopy and Raman signatures. We uncover an Fe-related spectral transition of Fe:MoS\u003Cjats:sub>2\u003C\u002Fjats:sub> monolayers that appears at 2.28 eV above the pristine bandgap and displays pronounced ferromagnetic hysteresis. The microscopic origin is further corroborated by density functional theory calculations of dipole-allowed transitions in Fe:MoS\u003Cjats:sub>2\u003C\u002Fjats:sub>. Using spatially integrating magnetization measurements and spatially resolving nitrogen-vacancy center magnetometry, we show that Fe:MoS\u003Cjats:sub>2\u003C\u002Fjats:sub> monolayers remain magnetized even at ambient conditions, manifesting ferromagnetism at room temperature.\u003C\u002Fjats:p>",{"EN":740,"VI":741},"Enabling room temperature ferromagnetism in monolayer MoS2 via in situ iron-doping","Kích hoạt tính sắt từ ở nhiệt độ phòng trong MoS2 đơn lớp bằng pha tạp sắt in 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Phys. 52, 340–343 (1984).",{"doi":1308},"10.1119\u002F1.13886",{"id":1310,"createTime":1311,"updateTime":1312,"relativeEntities":1313,"slug":1314,"properties":1315,"entityType":138,"verifyStatus":139,"verifyTime":1311,"verifyNote":140,"languages":1331,"translateLanguages":1332,"viewCount":19,"primaryUrl":1333,"fullTextUrl":18,"authors":1334,"publicationType":488,"publisherRelationship":1407,"citationCount":1459,"citationInfo":1460,"publishDate":18,"publishYear":18,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":1463,"openAccess":18,"references":1464,"isForceReanalyzing":723},"fcbc0d51-b01e-4a27-a256-9a904953ff8a","2024-12-29T21:02:57.896+00:00","2026-09-05T03:11:40.598+00:00",[],"Oxytocin-enhances-observational-fear-in-mice",{"mag":1316,"pmc":1318,"openalex":1320,"abstract":1322,"title":1324,"pm":1327,"doi":1329},{"VOID":1317},"2773566393",{"VOID":1319},"5727393",{"VOID":1321},"W2773566393",{"EN":1323},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Empathy is fundamental to human relations, but its neural substrates remain largely unknown. Here we characterize the involvement of oxytocin in the capacity of mice to display emotional state-matching, an empathy-like behavior. When exposed to a familiar conspecific demonstrator in distress, an observer mouse becomes fearful, as indicated by a tendency to freeze and subsequent efforts to escape. Both intranasal oxytocin administration and chemogenetic stimulation of oxytocin neurons render males sensitive to the distress of an unfamiliar mouse. Acute intranasal oxytocin penetrates the brain and enhances cellular activity within the anterior cingulate cortex, whereas chronic administration produces long-term facilitation of observational fear and downregulates oxytocin receptor expression in the amygdala. None of these manipulations affect fear acquired as a result of direct experience with the stressor. Hence, these results implicate oxytocin in observational fear in mice (rather than fear itself) and provide new avenues for examining the neural substrates of empathy.\u003C\u002Fjats:p>",{"EN":1325,"VI":1326},"Oxytocin enhances observational fear in mice","Oxytocin tăng cường nỗi sợ qua quan sát ở chuột nhắt",{"VOID":1328},"29235461",{"VOID":1330},"10.1038\u002Fs41467-017-02279-5",[142],[144],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41467-017-02279-5",[1335,1354,1373,1392],{"id":1336,"sortIndex":19,"researcher":18,"roles":1337,"affiliations":1338,"properties":1347,"displayName":1351,"givenName":18,"familyName":18},"2f5e0931-673e-423d-b50d-fb023d08f4ff",[],[1339],{"id":1340,"sortIndex":19,"affiliation":1341,"properties":18},"e916eb60-ee43-4be8-9c82-dfaa75caaa6a",{"id":1340,"createTime":18,"updateTime":18,"relativeEntities":1342,"slug":18,"properties":1343,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1346,"statistic":18},[],{"title":1344},{"EN":1345},"Graduate Program in Neuroscience, University of Minnesota—Twin Cities, Jackson Hall 6-145, 321 Church St SE, Minneapolis, MN, 55455, USA",[],{"orcid":1348,"title":1350,"openalex":1352},{"VOID":1349},"https:\u002F\u002Forcid.org\u002F0000-0002-9462-7714",{"EN":1351},"Marc T. 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(2014).",{"doi":1774},"10.1038\u002Fnn.3634",{"id":1776,"createTime":1777,"updateTime":1778,"relativeEntities":1779,"slug":1780,"properties":1781,"entityType":138,"verifyStatus":139,"verifyTime":1777,"verifyNote":140,"languages":1795,"translateLanguages":1796,"viewCount":19,"primaryUrl":1797,"fullTextUrl":18,"authors":1798,"publicationType":488,"publisherRelationship":1835,"citationCount":1888,"citationInfo":1889,"publishDate":18,"publishYear":18,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":1891,"openAccess":18,"references":1892,"isForceReanalyzing":723},"392f41dc-f620-405a-ba08-663fb20fc6af","2024-11-29T08:41:31.028+00:00","2026-09-05T02:12:19.719+00:00",[],"Irrelevance-of-linear-controllability-to-nonlinear-dynamical-networks",{"openalex":1782,"mag":1784,"abstract":1786,"title":1788,"pm":1791,"doi":1793},{"VOID":1783},"W3099723344",{"VOID":1785},"3099723344",{"EN":1787},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>There has been tremendous development in linear controllability of complex networks. Real-world systems are fundamentally nonlinear. Is linear controllability relevant to nonlinear dynamical networks? We identify a common trait underlying both types of control: the nodal “importance”. For nonlinear and linear control, the importance is determined, respectively, by physical\u002Fbiological considerations and the probability for a node to be in the minimum driver set. We study empirical mutualistic networks and a gene regulatory network, for which the nonlinear nodal importance can be quantified by the ability of individual nodes to restore the system from the aftermath of a tipping-point transition. We find that the nodal importance ranking for nonlinear and linear control exhibits opposite trends: for the former large-degree nodes are more important but for the latter, the importance scale is tilted towards the small-degree nodes, suggesting strongly the irrelevance of linear controllability to these systems. The recent claim of successful application of linear controllability to \u003Cjats:italic>Caenorhabditis\u003C\u002Fjats:italic>\u003Cjats:italic> elegans\u003C\u002Fjats:italic> connectome is examined and discussed.\u003C\u002Fjats:p>",{"EN":1789,"VI":1790},"Irrelevance of linear controllability to nonlinear dynamical networks","Tính không liên quan của khả năng kiểm soát tuyến tính đối với các mạng động lực phi tuyến",{"VOID":1792},"31481693",{"VOID":1794},"10.1038\u002Fs41467-019-11822-5",[142],[144],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41467-019-11822-5",[1799,1818],{"id":1800,"sortIndex":19,"researcher":18,"roles":1801,"affiliations":1802,"properties":1811,"displayName":1815,"givenName":18,"familyName":18},"50e3ac16-001f-4b32-864a-e99c10a38225",[],[1803],{"id":1804,"sortIndex":19,"affiliation":1805,"properties":18},"4ace6993-1623-4dde-9fc8-00cdfc26f9ee",{"id":1804,"createTime":18,"updateTime":18,"relativeEntities":1806,"slug":18,"properties":1807,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1810,"statistic":18},[],{"title":1808},{"VI":1809},"School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA",[],{"orcid":1812,"title":1814,"openalex":1816},{"VOID":1813},"https:\u002F\u002Forcid.org\u002F0000-0003-2930-7770",{"EN":1815},"Junjie Jiang",{"VOID":1817},"A5075909484",{"id":1819,"sortIndex":100,"researcher":18,"roles":1820,"affiliations":1821,"properties":1828,"displayName":1832,"givenName":18,"familyName":18},"6c8da4e0-75b0-4f6c-9be0-36c04febf09b",[],[1822],{"id":1804,"sortIndex":19,"affiliation":1823,"properties":18},{"id":1804,"createTime":18,"updateTime":18,"relativeEntities":1824,"slug":18,"properties":1825,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1827,"statistic":18},[],{"title":1826},{"VI":1809},[],{"orcid":1829,"title":1831,"openalex":1833},{"VOID":1830},"https:\u002F\u002Forcid.org\u002F0000-0002-0723-733X",{"EN":1832},"Ying‐Cheng Lai",{"VOID":1834},"A5102995786",{"url":18,"publisher":1836,"properties":1884},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1837,"slug":10,"properties":1838,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1841,"manageAffiliations":1853,"indexDatabases":1864,"url":18,"thumbnailPath":18,"statistic":1879,"gsStatistic":18,"type":111,"analyzePriority":18},[],{"issn":1839,"title":1840},{"VOID":13},{"EN":15},[1842,1845,1849],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":1843,"label":1844,"description":18,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{"id":27,"createTime":18,"updateTime":18,"relativeEntities":1846,"label":1847,"description":1848,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":30},{},{"id":33,"createTime":18,"updateTime":18,"relativeEntities":1850,"label":1851,"description":1852,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":36},{},[1854,1859],{"id":40,"createTime":18,"updateTime":18,"relativeEntities":1855,"slug":18,"properties":1856,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1858,"statistic":18},[],{"title":1857},{"EN":44},[],{"id":47,"createTime":18,"updateTime":18,"relativeEntities":1860,"slug":18,"properties":1861,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1863,"statistic":18},[],{"title":1862},{"EN":51},[],[1865,1872],{"id":55,"indexDatabase":1866,"url":66,"indexYears":67,"academicFieldIds":1871,"indexDatabaseRanking":72},{"id":57,"createTime":18,"updateTime":18,"relativeEntities":1867,"label":1868,"description":1869,"key":63,"publicationTags":1870,"standard":18},[],{"EN":60,"VI":60},{"EN":60,"VI":62},[65],[69,70,71],{"id":74,"indexDatabase":1873,"url":87,"indexYears":18,"academicFieldIds":1878,"indexDatabaseRanking":18},{"id":76,"createTime":18,"updateTime":18,"relativeEntities":1874,"label":1875,"description":1876,"key":83,"publicationTags":1877,"standard":18},[],{"EN":79,"VI":79},{"EN":81,"VI":82},[85,86],[89],{"impactFactor":19,"impactFactorByYear":1880,"i10Index":96,"i10IndexLast5Year":97,"totalPublication":98,"totalPublicationByYear":1881,"totalCitation":101,"totalCitationByYear":1882,"totalCitationPerPublication":107,"totalCitationPerPublicationByYear":1883,"hindexLast5Year":110,"hindex":110},{"2015":92,"2016":93,"2022":94,"2023":95},{"2014":100,"2019":100,"2021":97,"2024":100},{"2014":103,"2019":104,"2021":105,"2024":106},{"2014":103,"2019":104,"2021":109,"2024":106},{"issue":1885,"volume":1886},{"VOID":540},{"VOID":1887},"10",22,{"total":1888,"publishYear":18,"statisticByYear":1890},{"2020":271,"2021":253,"2022":219,"2023":219},[],[1893,1897,1901,1905,1909,1913,1917,1921,1925,1929,1933,1937,1941,1945,1948,1952,1956,1960,1964,1968,1972,1976,1980,1984,1988,1991,1995,1998,2002,2006,2010,2014,2018,2022,2026,2030,2034,2038,2042,2046,2050,2054,2058,2062,2066,2070,2074,2078,2082,2086,2090,2094,2098,2102,2106,2110,2114,2118,2122,2126,2130,2134,2138,2142,2146,2150,2154,2158,2162,2166],{"id":18,"text":1894,"url":18,"identifiers":1895},"Ott, 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Science 336, 1175–1177 (2012).",{"doi":2117},"10.1126\u002Fscience.1219805",{"id":18,"text":2119,"url":18,"identifiers":2120},"Boettiger, C. & Hastings, A. Tipping points: from patterns to predictions. Nature 493, 157–158 (2013).",{"doi":2121},"10.1038\u002F493157a",{"id":18,"text":2123,"url":18,"identifiers":2124},"Tylianakis, J. M. & Coux, C. Tipping points in ecological networks. Trends Plant Sci. 19, 281–283 (2014).",{"doi":2125},"10.1016\u002Fj.tplants.2014.03.006",{"id":18,"text":2127,"url":18,"identifiers":2128},"Campbell, C. et al. Correlations in the degeneracy of structurally control lable topologies for networks. Sci. Rep. 7, 46251 (2017).",{"doi":2129},"10.1038\u002Fsrep46251",{"id":18,"text":2131,"url":18,"identifiers":2132},"Gu, S. et al. Controllability of structural brain networks. Nat. Commun. 6, 8414 (2015).",{"doi":2133},"10.1038\u002Fncomms9414",{"id":18,"text":2135,"url":18,"identifiers":2136},"Muldoon, S. F. et al. Stimulation-based control of dynamic brain networks. PLoS Comput. Biol. 12, e1005076 (2016).",{"doi":2137},"10.1371\u002Fjournal.pcbi.1005076",{"id":18,"text":2139,"url":18,"identifiers":2140},"Tang, E. et al. Developmental increases in white matter network controllability support a growing diversity of brain dynamics. Nat. Commun. 8, 1252 (2017).",{"doi":2141},"10.1038\u002Fs41467-017-01254-4",{"id":18,"text":2143,"url":18,"identifiers":2144},"Tang, E. & Bassett, D. S. Colloquium: control of dynamics in brain networks. Rev. Mod. Phys. 90, 031003 (2018).",{"doi":2145},"10.1103\u002FRevModPhys.90.031003",{"id":18,"text":2147,"url":18,"identifiers":2148},"Holling, C. S. Some characteristics of simple types of predation and parasitism. Can. Entomol. 91, 385–398 (1959).",{"doi":2149},"10.4039\u002FEnt91385-7",{"id":18,"text":2151,"url":18,"identifiers":2152},"Holling, C. S. Resilience and stability of ecological systems. Annu. Rev. Ecol. Syst. 4, 1–23 (1973).",{"doi":2153},"10.1146\u002Fannurev.es.04.110173.000245",{"id":18,"text":2155,"url":18,"identifiers":2156},"Dupont, Y. L., Hansen, D. M. & Olesen, J. M. Structure of a plant–flower-visitor network in the high-altitude sub-alpine desert of Tenerife, Canary Islands. Ecography 26, 301–310 (2003).",{"doi":2157},"10.1034\u002Fj.1600-0587.2003.03443.x",{"id":18,"text":2159,"url":18,"identifiers":2160},"Memmott, J. The structure of a plant–pollinator food web. Ecol. Lett. 2, 276–280 (1999).",{"doi":2161},"10.1046\u002Fj.1461-0248.1999.00087.x",{"id":18,"text":2163,"url":18,"identifiers":2164},"Percival, M. Floral ecology of coastal scrub in southeast jamaica. Biotropica 6, 104–129 (1974).",{"doi":2165},"10.2307\u002F2989824",{"id":18,"text":2167,"url":18,"identifiers":2168},"Rugh, W. J. Linear Systems Theory. 2nd edn (Prentice-Hall, New Jersey, 1996).",{},{"id":2170,"createTime":2171,"updateTime":2172,"relativeEntities":2173,"slug":2174,"properties":2175,"entityType":138,"verifyStatus":139,"verifyTime":2191,"verifyNote":140,"languages":2192,"translateLanguages":2193,"viewCount":19,"primaryUrl":2194,"fullTextUrl":18,"authors":2195,"publicationType":488,"publisherRelationship":2408,"citationCount":2461,"citationInfo":2462,"publishDate":18,"publishYear":18,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":2464,"openAccess":18,"references":2465,"isForceReanalyzing":723},"547737f2-d977-4295-ac53-ab14e353a7d7","2024-09-01T16:11:07.764+00:00","2026-09-04T12:14:56.882+00:00",[],"The-Holocene-retreat-dynamics-and-stability-of-Petermann-Glacier-in-northwest-Greenland",{"mag":2176,"pmc":2178,"openalex":2180,"abstract":2182,"title":2184,"pm":2187,"doi":2189},{"VOID":2177},"2805202119",{"VOID":2179},"5974188",{"VOID":2181},"W2805202119",{"EN":2183},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Submarine glacial landforms in fjords are imprints of the dynamic behaviour of marine-terminating glaciers and are informative about their most recent retreat phase. 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The palaeodepth limit of the recessional moraines is consistent with final collapse driven by marine ice cliff instability (MICI) with retreat to the next stable position located underneath the present Petermann ice tongue, where the seafloor is unmapped.\u003C\u002Fjats:p>",{"EN":2185,"VI":2186},"The Holocene retreat dynamics and stability of Petermann Glacier in northwest Greenland","Động lực thoái lui và độ ổn định trong kỷ Holocen của sông băng Petermann ở tây bắc Greenland",{"VOID":2188},"29844384",{"VOID":2190},"10.1038\u002Fs41467-018-04573-2","2024-09-01T16:11:07.763+00:00",[142],[144],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41467-018-04573-2",[2196,2215,2234,2253,2272,2291,2308,2325,2340,2355,2374,2391],{"id":2197,"sortIndex":19,"researcher":18,"roles":2198,"affiliations":2199,"properties":2208,"displayName":2212,"givenName":18,"familyName":18},"6d4d6984-841d-4ec0-beb7-22c3d6444538",[],[2200],{"id":2201,"sortIndex":19,"affiliation":2202,"properties":18},"46a3268c-1112-42a5-833f-6cb3dde5e06b",{"id":2201,"createTime":18,"updateTime":18,"relativeEntities":2203,"slug":18,"properties":2204,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2207,"statistic":18},[],{"title":2205},{"VI":2206},"Department of Geological Sciences, Stockholm University, 106 91 Stockholm, Sweden",[],{"orcid":2209,"title":2211,"openalex":2213},{"VOID":2210},"https:\u002F\u002Forcid.org\u002F0000-0002-9033-3559",{"EN":2212},"Martin Jakobsson",{"VOID":2214},"A5051615747",{"id":2216,"sortIndex":100,"researcher":18,"roles":2217,"affiliations":2218,"properties":2227,"displayName":2231,"givenName":18,"familyName":18},"b83353e0-d42c-4275-98c5-d5290f458e69",[],[2219],{"id":2220,"sortIndex":19,"affiliation":2221,"properties":18},"e369851d-7d11-43f5-8124-79730295e0b1",{"id":2220,"createTime":18,"updateTime":18,"relativeEntities":2222,"slug":18,"properties":2223,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2226,"statistic":18},[],{"title":2224},{"VI":2225},"British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, Cambridge CB3 0ET, UK",[],{"orcid":2228,"title":2230,"openalex":2232},{"VOID":2229},"https:\u002F\u002Forcid.org\u002F0000-0002-1256-8010",{"EN":2231},"Kelly Hogan",{"VOID":2233},"A5090441551",{"id":2235,"sortIndex":94,"researcher":18,"roles":2236,"affiliations":2237,"properties":2246,"displayName":2250,"givenName":18,"familyName":18},"e7a6cf3b-3299-4a1d-9496-34963c70e131",[],[2238],{"id":2239,"sortIndex":19,"affiliation":2240,"properties":18},"4cdd076f-c77c-41fb-af6b-aa156457fd38",{"id":2239,"createTime":18,"updateTime":18,"relativeEntities":2241,"slug":18,"properties":2242,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":2245,"statistic":18},[],{"title":2243},{"VI":2244},"Center for Coastal and Ocean Mapping, University of New Hampshire, Durham, NH 03824, USA",[],{"orcid":2247,"title":2249,"openalex":2251},{"VOID":2248},"https:\u002F\u002Forcid.org\u002F0000-0003-1846-5140",{"EN":2250},"Larry A. 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Jr. Engineering BioBrick vectors from BioBrick parts. J. Biol. Eng. 2, 5 (2008).",{"doi":2940},"10.1186\u002F1754-1611-2-5",{"id":18,"text":2942,"url":18,"identifiers":2943},"Smolke, C. D. Building outside of the box: iGEM and the BioBricks Foundation. Nat. Biotechnol. 27, 1099–1102 (2009).",{"doi":2944},"10.1038\u002Fnbt1209-1099",{"id":18,"text":2946,"url":18,"identifiers":2947},"Banks, C. A., Boanca, G., Lee, Z. T., Florens, L. & Washburn, M. P. Proteins interacting with cloning scars: a source of false positive protein-protein interactions. Sci. Rep. 5, 8530 (2015).",{"doi":2948},"10.1038\u002Fsrep08530",{"id":18,"text":2950,"url":18,"identifiers":2951},"Gibson, D. G. et al. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 6, 343–345 (2009).",{"doi":2952},"10.1038\u002Fnmeth.1318",{"id":18,"text":2954,"url":18,"identifiers":2955},"Engler, C., Kandzia, R. & Marillonnet, S. 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One step DNA assembly for combinatorial metabolic engineering. Metab. Eng. 23, 70–77 (2014).",{"doi":2996},"10.1016\u002Fj.ymben.2014.02.012",{"id":18,"text":2998,"url":18,"identifiers":2999},"Kang, S. Y. et al. Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain. Micro. Cell Fact. 11, 153 (2012).",{"doi":3000},"10.1186\u002F1475-2859-11-153",{"id":18,"text":3002,"url":18,"identifiers":3003},"Kim, B., Binkley, R., Kim, H. U. & Lee, S. Y. Metabolic engineering of Escherichia coli for the enhanced production of l-tyrosine. Biotechnol. Bioeng. 115, 2554–2564 (2018).",{"doi":3004},"10.1002\u002Fbit.26797",{"id":18,"text":3006,"url":18,"identifiers":3007},"Jones, J. A. et al. Complete biosynthesis of anthocyanins using E. coli polycultures. MBio 8, e00621–00617 (2017).",{},{"id":18,"text":3009,"url":18,"identifiers":3010},"Li, M. Z. & Elledge, S. J. Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat. Methods 4, 251 (2007).",{"doi":3011},"10.1038\u002Fnmeth1010",{"id":18,"text":3013,"url":18,"identifiers":3014},"Shao, Z., Zhao, H. & Zhao, H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucl. Acids Res 37, e16–e16 (2008).",{"doi":3015},"10.1093\u002Fnar\u002Fgkn991",{"id":18,"text":3017,"url":18,"identifiers":3018},"Du, J., Yuan, Y., Si, T., Lian, J. & Zhao, H. Customized optimization of metabolic pathways by combinatorial transcriptional engineering. Nucl. Acids Res 40, e142–e142 (2012).",{"doi":3019},"10.1093\u002Fnar\u002Fgks549",{"id":18,"text":3021,"url":18,"identifiers":3022},"Ma, X., Liang, H., & Zhou, K. Constructing plasmid under GT DNA assembly standard. Protocol Exchange (2019) https:\u002F\u002Fdoi.org\u002F10.21203\u002Frs.2.10082\u002Fv1.",{"doi":3023},"10.21203\u002Frs.2.10082\u002Fv1",{"id":18,"text":3025,"url":18,"identifiers":3026},"Jiang, Y. et al. Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system. Appl Environ. Microbiol 81, 2506–2514 (2015).",{"doi":3027},"10.1128\u002FAEM.04023-14",{"id":3029,"createTime":3030,"updateTime":3031,"relativeEntities":3032,"slug":3033,"properties":3034,"entityType":138,"verifyStatus":139,"verifyTime":3030,"verifyNote":140,"languages":3050,"translateLanguages":3051,"viewCount":19,"primaryUrl":3052,"fullTextUrl":18,"authors":3053,"publicationType":488,"publisherRelationship":3109,"citationCount":2916,"citationInfo":3161,"publishDate":18,"publishYear":18,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":3163,"openAccess":18,"references":3164,"isForceReanalyzing":723},"16ccac03-70fc-4b41-b1e8-68c9b2ffcc4d","2024-09-02T20:26:47.721+00:00","2026-09-04T12:14:47.504+00:00",[],"WHAMM-initiates-autolysosome-tubulation-by-promoting-actin-polymerization-on-autolysosomes",{"mag":3035,"pmc":3037,"openalex":3039,"abstract":3041,"title":3043,"pm":3046,"doi":3048},{"VOID":3036},"2967298571",{"VOID":3038},"6697732",{"VOID":3040},"W2967298571",{"EN":3042},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>WHAMM, a member of the Wiskott-Aldrich syndrome protein (WASP) family, is an actin nucleation promoting factor (NPF) that also associates with membranes and microtubules. Here we report that WHAMM is required for autophagic lysosome reformation (ALR). WHAMM knockout causes impairment of autolysosome tubulation, which results in accumulation of enlarged autolysosomes during prolonged starvation. Mechanistically, WHAMM is recruited to the autolysosome membrane through its specific interaction with PI(4,5)P\u003Cjats:sub>2\u003C\u002Fjats:sub>. WHAMM then works as an NPF which promotes assembly of an actin scaffold on the surface of the autolysosome to promote autolysosome tubulation. Our study demonstrates an unexpected role of the actin scaffold in regulating autophagic lysosome reformation.\u003C\u002Fjats:p>",{"EN":3044,"VI":3045},"WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes","WHAMM khởi đầu sự tạo ống autolysosome bằng cách thúc đẩy quá trình trùng hợp actin trên autolysosome",{"VOID":3047},"31420534",{"VOID":3049},"10.1038\u002Fs41467-019-11694-9",[142],[144],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41467-019-11694-9",[3054,3073,3092],{"id":3055,"sortIndex":19,"researcher":18,"roles":3056,"affiliations":3057,"properties":3066,"displayName":3070,"givenName":18,"familyName":18},"a0ec1393-11f2-4525-bc73-9e0b000293fe",[],[3058],{"id":3059,"sortIndex":19,"affiliation":3060,"properties":18},"abdb6ad8-b074-4ac4-b15a-7127971d4e1a",{"id":3059,"createTime":18,"updateTime":18,"relativeEntities":3061,"slug":18,"properties":3062,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":3065,"statistic":18},[],{"title":3063},{"EN":3064},"Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking University Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Science, Tsinghua University, 100084, Beijing, China",[],{"orcid":3067,"title":3069,"openalex":3071},{"VOID":3068},"https:\u002F\u002Forcid.org\u002F0000-0003-3434-0663",{"EN":3070},"Anbang Dai",{"VOID":3072},"A5002387555",{"id":3074,"sortIndex":100,"researcher":18,"roles":3075,"affiliations":3076,"properties":3085,"displayName":3089,"givenName":18,"familyName":18},"fc2e9d75-8b0c-4334-9237-89efcde57643",[],[3077],{"id":3078,"sortIndex":19,"affiliation":3079,"properties":18},"33f63b88-c24c-40df-94da-d4ecd8755322",{"id":3078,"createTime":18,"updateTime":18,"relativeEntities":3080,"slug":18,"properties":3081,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":3084,"statistic":18},[],{"title":3082},{"EN":3083},"State Key Laboratory of Membrane Biology, Tsinghua-Peking University Joint Center for Life Sciences, School of Life Science, Tsinghua University, 100084, Beijing, China",[],{"orcid":3086,"title":3088,"openalex":3090},{"VOID":3087},"https:\u002F\u002Forcid.org\u002F0000-0001-7783-2321",{"EN":3089},"Li Yu",{"VOID":3091},"A5100784527",{"id":3093,"sortIndex":94,"researcher":18,"roles":3094,"affiliations":3095,"properties":3102,"displayName":3106,"givenName":18,"familyName":18},"5cb8cffa-04cd-4208-a036-8269715d393e",[],[3096],{"id":3059,"sortIndex":19,"affiliation":3097,"properties":18},{"id":3059,"createTime":18,"updateTime":18,"relativeEntities":3098,"slug":18,"properties":3099,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":3101,"statistic":18},[],{"title":3100},{"EN":3064},[],{"orcid":3103,"title":3105,"openalex":3107},{"VOID":3104},"https:\u002F\u002Forcid.org\u002F0000-0001-9494-8780",{"EN":3106},"Hongwei Wang",{"VOID":3108},"A5100357132",{"url":18,"publisher":3110,"properties":3158},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":3111,"slug":10,"properties":3112,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":3115,"manageAffiliations":3127,"indexDatabases":3138,"url":18,"thumbnailPath":18,"statistic":3153,"gsStatistic":18,"type":111,"analyzePriority":18},[],{"issn":3113,"title":3114},{"VOID":13},{"EN":15},[3116,3119,3123],{"id":22,"createTime":18,"updateTime":18,"relativeEntities":3117,"label":3118,"description":18,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":25},{"id":27,"createTime":18,"updateTime":18,"relativeEntities":3120,"label":3121,"description":3122,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":30},{},{"id":33,"createTime":18,"updateTime":18,"relativeEntities":3124,"label":3125,"description":3126,"parentId":18,"standard":18,"scholarHubFieldId":18},[],{"EN":36},{},[3128,3133],{"id":40,"createTime":18,"updateTime":18,"relativeEntities":3129,"slug":18,"properties":3130,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":3132,"statistic":18},[],{"title":3131},{"EN":44},[],{"id":47,"createTime":18,"updateTime":18,"relativeEntities":3134,"slug":18,"properties":3135,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":3137,"statistic":18},[],{"title":3136},{"EN":51},[],[3139,3146],{"id":55,"indexDatabase":3140,"url":66,"indexYears":67,"academicFieldIds":3145,"indexDatabaseRanking":72},{"id":57,"createTime":18,"updateTime":18,"relativeEntities":3141,"label":3142,"description":3143,"key":63,"publicationTags":3144,"standard":18},[],{"EN":60,"VI":60},{"EN":60,"VI":62},[65],[69,70,71],{"id":74,"indexDatabase":3147,"url":87,"indexYears":18,"academicFieldIds":3152,"indexDatabaseRanking":18},{"id":76,"createTime":18,"updateTime":18,"relativeEntities":3148,"label":3149,"description":3150,"key":83,"publicationTags":3151,"standard":18},[],{"EN":79,"VI":79},{"EN":81,"VI":82},[85,86],[89],{"impactFactor":19,"impactFactorByYear":3154,"i10Index":96,"i10IndexLast5Year":97,"totalPublication":98,"totalPublicationByYear":3155,"totalCitation":101,"totalCitationByYear":3156,"totalCitationPerPublication":107,"totalCitationPerPublicationByYear":3157,"hindexLast5Year":110,"hindex":110},{"2015":92,"2016":93,"2022":94,"2023":95},{"2014":100,"2019":100,"2021":97,"2024":100},{"2014":103,"2019":104,"2021":105,"2024":106},{"2014":103,"2019":104,"2021":109,"2024":106},{"issue":3159,"volume":3160},{"VOID":540},{"VOID":1887},{"total":2916,"publishYear":18,"statisticByYear":3162},{"2020":219,"2021":432,"2022":271,"2023":306,"2024":93},[],[3165,3169,3173,3177,3181,3185,3189,3193,3197,3201,3205,3209,3213,3217,3221,3225,3229,3233,3237,3241,3245,3249,3253,3257,3261,3265,3269,3273,3277,3281,3285,3289,3293,3297,3301,3305,3309,3313,3317,3321],{"id":18,"text":3166,"url":18,"identifiers":3167},"Mizushima, N. A brief history of autophagy from cell biology to physiology and disease. Nat. Cell Biol. 20, 521–527 (2018).",{"doi":3168},"10.1038\u002Fs41556-018-0092-5",{"id":18,"text":3170,"url":18,"identifiers":3171},"Yu, L. et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465, 942–946 (2010).",{"doi":3172},"10.1038\u002Fnature09076",{"id":18,"text":3174,"url":18,"identifiers":3175},"Yu, L., Chen, Y. & Tooze, S. A. Autophagy pathway: cellular and molecular mechanisms. Autophagy 14, 207–215 (2017).",{"doi":3176},"10.1080\u002F15548627.2017.1378838",{"id":18,"text":3178,"url":18,"identifiers":3179},"Rotty, J. D., Wu, C. & Bear, J. E. New insights into the regulation and cellular functions of the ARP2\u002F3 complex. Nat. Rev. Mol. Cell Biol. 14, 7–12 (2012).",{"doi":3180},"10.1038\u002Fnrm3492",{"id":18,"text":3182,"url":18,"identifiers":3183},"Papadopulos, A. Membrane shaping by actin and myosin during regulated exocytosis. Mol. Cell. Neurosci. 84, 93–99 (2017).",{"doi":3184},"10.1016\u002Fj.mcn.2017.05.006",{"id":18,"text":3186,"url":18,"identifiers":3187},"Aguilera, M. O., Berón, W. & Colombo, M. I. The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy. Autophagy 8, 1590–1603 (2014).",{"doi":3188},"10.4161\u002Fauto.21459",{"id":18,"text":3190,"url":18,"identifiers":3191},"Mi, N. et al. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nat. Cell Biol. 17, 1112–1123 (2015).",{"doi":3192},"10.1038\u002Fncb3215",{"id":18,"text":3194,"url":18,"identifiers":3195},"Tumbarello, D. A. et al. Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. Nat. Cell Biol. 14, 1024–1035 (2012).",{"doi":3196},"10.1038\u002Fncb2589",{"id":18,"text":3198,"url":18,"identifiers":3199},"Hasegawa, J. et al. Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome. EMBO J. 35, 1853–1867 (2016).",{"doi":3200},"10.15252\u002Fembj.201593148",{"id":18,"text":3202,"url":18,"identifiers":3203},"Lewellyn, E. B. et al. An engineered minimal WASP-myosin fusion protein reveals essential functions for endocytosis. Dev. Cell 35, 281–294 (2015).",{"doi":3204},"10.1016\u002Fj.devcel.2015.10.007",{"id":18,"text":3206,"url":18,"identifiers":3207},"Picco, A., Mund, M., Ries, J., Nédélec, F. & Kaksonen, M. Visualizing the functional architecture of the endocytic machinery. eLife 4, 04535 (2015).",{"doi":3208},"10.7554\u002FeLife.04535",{"id":18,"text":3210,"url":18,"identifiers":3211},"Collins, A., Warrington, A., Taylor, Kenneth, A. & Svitkina, T. Structural organization of the actin cytoskeleton at sites of clathrin-mediated endocytosis. Curr. Biol. 21, 1167–1175 (2011).",{"doi":3212},"10.1016\u002Fj.cub.2011.05.048",{"id":18,"text":3214,"url":18,"identifiers":3215},"Campellone, K. G., Webb, N. J., Znameroski, E. A. & Welch, M. D. WHAMM Is an Arp2\u002F3 complex activator that binds microtubules and functions in ER to golgi transport. Cell 134, 148–161 (2008).",{"doi":3216},"10.1016\u002Fj.cell.2008.05.032",{"id":18,"text":3218,"url":18,"identifiers":3219},"Kast, D. J. et al. WHAMM directs the Arp2\u002F3 complex to the ER for autophagosome biogenesis through an actin comet tail mechanism. Curr. Biol. 25, 1791–1797 (2015).",{"doi":3220},"10.1016\u002Fj.cub.2015.05.042",{"id":18,"text":3222,"url":18,"identifiers":3223},"Rong, Y. et al. Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat. Cell Biol. 14, 924–934 (2012).",{"doi":3224},"10.1038\u002Fncb2557",{"id":18,"text":3226,"url":18,"identifiers":3227},"Du, W. et al. Kinesin 1 drives autolysosome tubulation. Dev. Cell 37, 326–336 (2016).",{"doi":3228},"10.1016\u002Fj.devcel.2016.04.014",{"id":18,"text":3230,"url":18,"identifiers":3231},"Hetrick, B. et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2\u002F3 complex by blocking an activating conformational change. Chem. Biol. 20, 701–712 (2013).",{"doi":3232},"10.1016\u002Fj.chembiol.2013.03.019",{"id":18,"text":3234,"url":18,"identifiers":3235},"Welch, M. D., DePace, A. H., Verma, S., Iwamatsu, A. & Mitchison, T. J. The human Arp2\u002F3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J. Cell Biol. 138, 375–384 (1997).",{"doi":3236},"10.1083\u002Fjcb.138.2.375",{"id":18,"text":3238,"url":18,"identifiers":3239},"Shen, Q.-T. et al. Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. J. Cell Biol. 199, 111–124 (2012).",{"doi":3240},"10.1083\u002Fjcb.201204010",{"id":18,"text":3242,"url":18,"identifiers":3243},"Brown, D. A. PIP2Clustering: from model membranes to cells. Chem. Phys. Lipids 192, 33–40 (2015).",{"doi":3244},"10.1016\u002Fj.chemphyslip.2015.07.021",{"id":18,"text":3246,"url":18,"identifiers":3247},"Grinstein, S. Imaging signal transduction during phagocytosis: phospholipids, surface charge, and electrostatic interactions. Am. J. Physiol. Cell Physiol. 299, C876–C881 (2010).",{"doi":3248},"10.1152\u002Fajpcell.00342.2010",{"id":18,"text":3250,"url":18,"identifiers":3251},"Elliott, P. R. et al. The structure of the talin head reveals a novel extended conformation of the FERM domain. Structure 18, 1289–1299 (2010).",{"doi":3252},"10.1016\u002Fj.str.2010.07.011",{"id":18,"text":3254,"url":18,"identifiers":3255},"Papayannopoulos, V. et al. A polybasic motif allows N-WASP to act as a sensor of PIP2 density. Mol. Cell 17, 181–191 (2005).",{"doi":3256},"10.1016\u002Fj.molcel.2004.11.054",{"id":18,"text":3258,"url":18,"identifiers":3259},"Nath, S. et al. Lipidation of the LC3\u002FGABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nat. Cell Biol. 16, 415–424 (2014).",{"doi":3260},"10.1038\u002Fncb2940",{"id":18,"text":3262,"url":18,"identifiers":3263},"Bhatia, V. K. et al. Amphipathic motifs in BAR domains are essential for membrane curvature sensing. EMBO J. 28, 3303–3314 (2009).",{"doi":3264},"10.1038\u002Femboj.2009.261",{"id":18,"text":3266,"url":18,"identifiers":3267},"Tan, X., Thapa, N., Liao, Y., Choi, S. & Anderson, R. A. PtdIns(4,5)P2signaling regulates ATG14 and autophagy. Proc. Natl Acad. Sci. USA 113, 10896–10901 (2016).",{"doi":3268},"10.1073\u002Fpnas.1523145113",{"id":18,"text":3270,"url":18,"identifiers":3271},"Grassart, A. et al. Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis. J. Cell Biol. 205, 721–735 (2014).",{"doi":3272},"10.1083\u002Fjcb.201403041",{"id":18,"text":3274,"url":18,"identifiers":3275},"Almeida-Souza, L. et al. A Flat BAR protein promotes actin polymerization at the base of clathrin-coated pits. Cell 174, 325–337.e314 (2018).",{"doi":3276},"10.1016\u002Fj.cell.2018.05.020",{"id":18,"text":3278,"url":18,"identifiers":3279},"Jost, M., Simpson, F., Kavran, J. M., Lemmon, M. A. & Schmid, S. L. Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Curr. Biol. 8, 1399–1402 (1998).",{"doi":3280},"10.1016\u002FS0960-9822(98)00022-0",{"id":18,"text":3282,"url":18,"identifiers":3283},"Roberto Zoncu et al. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc. Natl Acad. Sci. USA 104, 3793–3798 (2007).",{"doi":3284},"10.1073\u002Fpnas.0611733104",{"id":18,"text":3286,"url":18,"identifiers":3287},"Carlsson, A. E. Membrane bending by actin polymerization. Curr. Opin. Cell Biol. 50, 1–7 (2018).",{"doi":3288},"10.1016\u002Fj.ceb.2017.11.007",{"id":18,"text":3290,"url":18,"identifiers":3291},"Kanai, Y., Wang, D. & Hirokawa, N. KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. J. Cell Biol. 204, 395–408 (2014).",{"doi":3292},"10.1083\u002Fjcb.201309066",{"id":18,"text":3294,"url":18,"identifiers":3295},"Gomez, T. S., Gorman, J. A., Narvajas, A. A.-Md, Koenig, A. O. & Billadeau, D. D. Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol. Biol. Cell 23, 3215–3228 (2012).",{"doi":3296},"10.1091\u002Fmbc.e12-02-0101",{"id":18,"text":3298,"url":18,"identifiers":3299},"Derivery, E. et al. The Arp2\u002F3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev. Cell 17, 712–723 (2009).",{"doi":3300},"10.1016\u002Fj.devcel.2009.09.010",{"id":18,"text":3302,"url":18,"identifiers":3303},"Saric, A. et al. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Mol. Biol. Cell 27, 321–333 (2016).",{"doi":3304},"10.1091\u002Fmbc.e15-05-0272",{"id":18,"text":3306,"url":18,"identifiers":3307},"Harrison, R. E., Bucci, C., Vieira, O. V., Schroer, T. A. & Grinstein, S. Phagosomes fuse with late endosomes and\u002For lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. Mol. Cell. Biol. 23, 6494–6506 (2003).",{"doi":3308},"10.1128\u002FMCB.23.18.6494-6506.2003",{"id":18,"text":3310,"url":18,"identifiers":3311},"Li, X. et al. A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation. Nat. Cell Biol. 18, 404–417 (2016).",{"doi":3312},"10.1038\u002Fncb3324",{"id":18,"text":3314,"url":18,"identifiers":3315},"Liu, T. et al. Structural Insights of WHAMM’s Interaction with Microtubules by Cryo-EM. J. Mol. Biol. 429, 1352–1363 (2017).",{"doi":3316},"10.1016\u002Fj.jmb.2017.03.022",{"id":18,"text":3318,"url":18,"identifiers":3319},"Jones, D. T. protein secondary structure prediction based on position-specific scoring matrices. J. Mol. Biol. 292, 195–202 (1999).",{"doi":3320},"10.1006\u002Fjmbi.1999.3091",{"id":18,"text":3322,"url":18,"identifiers":3323},"Gautier, R., Douguet, D., Antonny, B. & Drin, G. HELIQUEST: a web server to screen sequences with specific -helical properties. 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A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitaxel response has not been tested. Here, we show a previously unrecognized role of the microtubule-associated protein CRMP2 in inducing microtubule bundling through its carboxy terminus. This activity is significantly decreased when the FER tyrosine kinase phosphorylates CRMP2 at Y479 and Y499. The crystal structures of wild-type CRMP2 and CRMP2-Y479E reveal how mimicking phosphorylation prevents tetramerization of CRMP2. Depletion of FER or reducing its catalytic activity using sub-therapeutic doses of inhibitors increases paclitaxel-induced microtubule stability and cytotoxicity in ovarian cancer cells and in vivo. 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At seasonal and inter-seasonal timescales, the summer monsoon of one hemisphere is linked via outflows from the winter monsoon of the opposing hemisphere. Long-term phase relationships between the East Asian summer monsoon (EASM) and the Indonesian–Australian summer monsoon (IASM) are poorly understood, raising questions of long-term adjustments to future greenhouse-triggered climate change and whether these changes could ‘lock in’ possible IASM and EASM phase relationships in a region dependent on monsoonal rainfall. Here we show that a newly developed nonlinear time series analysis technique allows confident identification of strong versus weak monsoon phases at millennial to sub-centennial timescales. We find a see–saw relationship over the last 9,000 years—with strong and weak monsoons opposingly phased and triggered by solar variations. Our results provide insights into centennial- to millennial-scale relationships within the wider EAIASM regime.\u003C\u002Fjats:p>",{"EN":4129,"VI":4130},"See–saw relationship of the Holocene East Asian–Australian summer monsoon","Mối quan hệ bập bênh của gió mùa mùa hè Đông Á - Úc thời kỳ Holocen",{"VOID":4132},"27666662",{"VOID":4134},"10.1038\u002Fncomms12929",[142],[144],"https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fncomms12929",[4139,4158,4177,4192,4211,4228,4247,4264],{"id":4140,"sortIndex":19,"researcher":18,"roles":4141,"affiliations":4142,"properties":4151,"displayName":4155,"givenName":18,"familyName":18},"1ae11cc2-9bcc-40ef-9f62-26ed3ccd1e20",[],[4143],{"id":4144,"sortIndex":19,"affiliation":4145,"properties":18},"f09452c1-9a7d-4db2-8e7f-4075ff296ce1",{"id":4144,"createTime":18,"updateTime":18,"relativeEntities":4146,"slug":18,"properties":4147,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":4150,"statistic":18},[],{"title":4148},{"VI":4149},"Potsdam Institute for Climate Impact Research (PIK), Potsdam 14473, Germany",[],{"orcid":4152,"title":4154,"openalex":4156},{"VOID":4153},"https:\u002F\u002Forcid.org\u002F0000-0001-6725-6949",{"EN":4155},"Deniz Eroglu",{"VOID":4157},"A5060850775",{"id":4159,"sortIndex":100,"researcher":18,"roles":4160,"affiliations":4161,"properties":4170,"displayName":4174,"givenName":18,"familyName":18},"42be9f10-3a9d-44f2-bf16-40f9bdca6880",[],[4162],{"id":4163,"sortIndex":19,"affiliation":4164,"properties":18},"a2f42e44-bb70-4904-93a2-662d6e148476",{"id":4163,"createTime":18,"updateTime":18,"relativeEntities":4165,"slug":18,"properties":4166,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":4169,"statistic":18},[],{"title":4167},{"VI":4168},"School of Earth and Environment, The University of Western Australia, Crawley 6009, Western Australia, Australia",[],{"orcid":4171,"title":4173,"openalex":4175},{"VOID":4172},"https:\u002F\u002Forcid.org\u002F0000-0002-2256-2544",{"EN":4174},"Fiona H. 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