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10.1128\u002FAAC.48.1.216-223.2004",{"doi":352},"10.1128\u002FAAC.48.1.216-223.2004",false,{"id":355,"createTime":356,"updateTime":357,"relativeEntities":358,"slug":359,"properties":360,"entityType":121,"verifyStatus":122,"verifyTime":377,"verifyNote":123,"languages":378,"translateLanguages":379,"viewCount":24,"primaryUrl":381,"fullTextUrl":23,"authors":382,"publicationType":223,"publisherRelationship":447,"citationCount":501,"citationInfo":502,"publishDate":505,"publishYear":503,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":506,"openAccess":23,"references":507,"isForceReanalyzing":353},"13355697-8aea-47ad-a8e3-793e5b5b6526","2024-10-02T06:34:59.504+00:00","2025-02-23T01:45:09.545+00:00",[],"Oral-Itraconazole-Therapy-for-Mycotic-Keratitis-Orale-Itraconazol-Therapie-bei-mykotischer-Keratitis",{"mag":361,"keywords":363,"openalex":365,"abstract":367,"title":370,"pm":373,"doi":375},{"VOID":362},"1965429232",{"VI":364},"",{"VOID":366},"W1965429232",{"EN":368,"VI":369},"\u003Cjats:p>\u003Cjats:bold>Summary: \u003C\u002Fjats:bold> Forty consecutive patients suffering from mycotic keratitis (19 due to \u003Cjats:italic>Fusarium solani\u003C\u002Fjats:italic> and other \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> spp., 15 due to \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> and \u003Cjats:italic>Aspergillus fumigatus\u003C\u002Fjats:italic> and six cases due to other fungi) were treated with itraconazole, a triazole derivative. The compound was administered orally once daily in a dose of 200 mg for a median duration of treatment of 17 days. Progressive corneal ulceration stopped and there was complete resolution of all lesions and eradication of the infecting fungus from the lesions in 22 patients. In five patients, the infecting fungi were eradicated from the lesions but ultimately surgery had to be performed due to incomplete resolution of the lesions. In the remaining 13 patients, progressive corneal ulceration continued and the infecting fungi (\u003Cjats:italic>F. solani\u003C\u002Fjats:italic> and other \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> spp. in nine patients, \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> in two patients, \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> in one and \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> spp. in one patient) were not eradicated from the lesion. Excellent or moderate responsiveness to therapy was observed more frequently in cases of keratitis due to \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> than in cases of keratitis due to \u003Cjats:italic>Fusarium.\u003C\u002Fjats:italic> There was no evidence of serious adverse reactions in any of the patients.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Zusammenfassung: \u003C\u002Fjats:bold> Vierzig Patienten mit mykotischer Keratitis (19 verursacht durch \u003Cjats:italic>Fusarium solani\u003C\u002Fjats:italic> und andere \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>‐Arten, 15 durch \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> und \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> und 6 durch andere Pilze) wurden mit dem Triazol‐Derivat Itraconazol behandelt. Das Mittel wurde einmal täglich in einer Dosis von 200 mg bei einer mittleren Behandlungsdauer von 17 d gegeben. Bei 22 Patienten kam die progrediente Hornhautulzeration zum Still‐stand, es kam zur vollständigen Ausheilung aller Läsionen und zur Eliminierung des Pilzes. Bei 5 Patienten konnte der Pilz eliminiert werden, jedoch mußte wegen der nur unvollständigen Abheilung der Läsionen chirurgisch nachbehandelt werden. Bei den restlichen 13 Patienten schritt die Hornhautulzeration weiter fort und der Erreger (\u003Cjats:italic>F. solani\u003C\u002Fjats:italic> und andere \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>‐Arten bei 9 Patienten, \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> bei 2 und \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> und \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> spec. in je einem Patienten) konnten nicht aus den Läsionen eliminiert werden. Hervorragendes und mäßiges Ansprechen auf die Therapie wurde Öfter bei \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic>‐bedingter als bei \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>‐bedingter Keratitis beobachtet. Ernsthafte Nebenwirkungen wurden bei keinem der Patienten gesehen.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>Tóm tắt: \u003C\u002Fjats:bold> Bốn mươi bệnh nhân liên tiếp mắc keratitis nấm (19 bệnh nhân do \u003Cjats:italic>Fusarium solani\u003C\u002Fjats:italic> và các loài \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> khác, 15 bệnh nhân do \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> và \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> và sáu trường hợp do các nấm khác) đã được điều trị bằng itraconazole, một dẫn xuất triazole. Chất này được dùng đường uống một lần mỗi ngày với liều 200 mg trong thời gian điều trị trung bình là 17 ngày. Sự loét tiến triển của giác mạc đã dừng lại và có sự giải quyết hoàn toàn của tất cả các tổn thương và tiêu diệt nấm gây bệnh khỏi tổn thương ở 22 bệnh nhân. Ở năm bệnh nhân, các nấm gây bệnh đã được tiêu diệt khỏi tổn thương nhưng cuối cùng phải thực hiện phẫu thuật do sự giải quyết chưa hoàn toàn của các tổn thương. Trong 13 bệnh nhân còn lại, sự loét giác mạc tiến triển vẫn tiếp tục và các nấm gây bệnh (\u003Cjats:italic>F. solani\u003C\u002Fjats:italic> và các loài \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> khác ở chín bệnh nhân, \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> ở hai bệnh nhân, \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> ở một bệnh nhân và \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> spp. ở một bệnh nhân) đã không được tiêu diệt khỏi tổn thương. Đáp ứng hoàn hảo hoặc trung bình đối với liệu pháp được quan sát thấy thường xuyên hơn trong các trường hợp keratitis do \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> hơn là do \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>. Không có bằng chứng nào về các phản ứng phụ nghiêm trọng ở bất kỳ bệnh nhân nào.\u003C\u002Fjats:p>",{"EN":371,"VI":372},"Oral Itraconazole Therapy for Mycotic Keratitis\u002FOrale Itraconazol‐Therapie bei mykotischer Keratitis","Liệu pháp Itraconazole đường uống cho Keratitis mycotic",{"VOID":374},"2843767",{"VOID":376},"10.1111\u002Fj.1439-0507.1988.tb03986.x","2024-10-02T06:34:59.503+00:00",[125],[380],"VI","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.1988.tb03986.x",[383,402,417,432],{"id":384,"sortIndex":24,"researcher":23,"roles":385,"affiliations":386,"properties":395,"displayName":399,"givenName":23,"familyName":23},"1069020b-38cb-4895-9cc8-cb655c36fbbc",[],[387],{"id":388,"sortIndex":24,"affiliation":389,"properties":23},"6ddf6ad5-19d5-4136-b94e-b4406a4fc302",{"id":388,"createTime":23,"updateTime":23,"relativeEntities":390,"slug":23,"properties":391,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":394,"statistic":23},[],{"title":392},{"EN":393},"Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India",[],{"orcid":396,"title":398,"openalex":400},{"VOID":397},"https:\u002F\u002Forcid.org\u002F0000-0002-0585-0499",{"EN":399},"Philip A. Thomas",{"VOID":401},"A5035315976",{"id":403,"sortIndex":147,"researcher":23,"roles":404,"affiliations":405,"properties":412,"displayName":414,"givenName":23,"familyName":23},"d687152d-32da-4a66-aee1-d135e8e03580",[],[406],{"id":388,"sortIndex":24,"affiliation":407,"properties":23},{"id":388,"createTime":23,"updateTime":23,"relativeEntities":408,"slug":23,"properties":409,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":411,"statistic":23},[],{"title":410},{"EN":393},[],{"title":413,"openalex":415},{"EN":414},"Delmy Abraham",{"VOID":416},"A5013839021",{"id":418,"sortIndex":169,"researcher":23,"roles":419,"affiliations":420,"properties":427,"displayName":429,"givenName":23,"familyName":23},"127bde95-7a44-4487-932d-48de0df22ac8",[],[421],{"id":388,"sortIndex":24,"affiliation":422,"properties":23},{"id":388,"createTime":23,"updateTime":23,"relativeEntities":423,"slug":23,"properties":424,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":426,"statistic":23},[],{"title":425},{"EN":393},[],{"title":428,"openalex":430},{"EN":429},"C M Kalavathy",{"VOID":431},"A5017901952",{"id":433,"sortIndex":189,"researcher":23,"roles":434,"affiliations":435,"properties":442,"displayName":444,"givenName":23,"familyName":23},"daf11d52-af18-4f5d-a2ae-97209182b155",[],[436],{"id":388,"sortIndex":24,"affiliation":437,"properties":23},{"id":388,"createTime":23,"updateTime":23,"relativeEntities":438,"slug":23,"properties":439,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":441,"statistic":23},[],{"title":440},{"EN":393},[],{"title":443,"openalex":445},{"EN":444},"J. Rajasekaran",{"VOID":446},"A5025355280",{"url":23,"publisher":448,"properties":494},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":449,"slug":10,"properties":450,"entityType":21,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":24,"subjectFields":455,"manageAffiliations":468,"indexDatabases":479,"url":97,"thumbnailPath":23,"statistic":23,"gsStatistic":23,"type":23,"analyzePriority":23},[],{"country":451,"eissn":452,"issn":453,"title":454},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":10},[456,460,464],{"id":27,"createTime":23,"updateTime":23,"relativeEntities":457,"label":458,"description":459,"parentId":23,"standard":23,"scholarHubFieldId":23},[],{"EN":30},{},{"id":33,"createTime":23,"updateTime":23,"relativeEntities":461,"label":462,"description":463,"parentId":23,"standard":23,"scholarHubFieldId":23},[],{"EN":36},{},{"id":39,"createTime":23,"updateTime":23,"relativeEntities":465,"label":466,"description":467,"parentId":23,"standard":23,"scholarHubFieldId":23},[],{"EN":42},{},[469,474],{"id":46,"createTime":23,"updateTime":23,"relativeEntities":470,"slug":23,"properties":471,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":473,"statistic":23},[],{"title":472},{"EN":50},[],{"id":53,"createTime":23,"updateTime":23,"relativeEntities":475,"slug":23,"properties":476,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":478,"statistic":23},[],{"title":477},{"EN":57},[],[480,487],{"id":61,"indexDatabase":481,"url":74,"indexYears":23,"academicFieldIds":486,"indexDatabaseRanking":23},{"id":63,"createTime":23,"updateTime":23,"relativeEntities":482,"label":483,"description":484,"key":70,"publicationTags":485,"standard":23},[],{"EN":66,"VI":66},{"EN":68,"VI":69},[72,73],[76,77],{"id":79,"indexDatabase":488,"url":90,"indexYears":91,"academicFieldIds":493,"indexDatabaseRanking":96},{"id":81,"createTime":23,"updateTime":23,"relativeEntities":489,"label":490,"description":491,"key":87,"publicationTags":492,"standard":23},[],{"EN":84,"VI":84},{"EN":84,"VI":86},[89],[93,94,95],{"issue":495,"pages":497,"volume":499},{"VOID":496},"5",{"VOID":498},"271-279",{"VOID":500},"31",54,{"total":501,"publishYear":503,"statisticByYear":504},1988,{"2013":147,"2014":207,"2015":169,"2019":147,"2021":147},"1988-05-01",[96,72],[508,511,514,517,520,523,526,529,532,535,538,541,544,547,550,553],{"id":23,"text":509,"url":23,"identifiers":510},"10.1093\u002Fclinids\u002F9.Supplement_1.S146",{"doi":509},{"id":23,"text":512,"url":23,"identifiers":513},"10.1093\u002Fclinids\u002F9.Supplement_1.S71",{"doi":512},{"id":23,"text":515,"url":23,"identifiers":516},"Emmons C. W., 1977, Medical Mycology, 85",{},{"id":23,"text":518,"url":23,"identifiers":519},"10.1128\u002FAAC.26.1.5",{"doi":518},{"id":23,"text":521,"url":23,"identifiers":522},"10.1128\u002FAAC.26.5.773",{"doi":521},{"id":23,"text":524,"url":23,"identifiers":525},"Forster R. K., 1983, The cornea: scientific foundations and clinical practice, 168",{},{"id":23,"text":527,"url":23,"identifiers":528},"10.1001\u002Farchopht.1981.03930011081019",{"doi":527},{"id":23,"text":530,"url":23,"identifiers":531},"10.1016\u002F0002-9394(75)90730-8",{"doi":530},{"id":23,"text":533,"url":23,"identifiers":534},"10.1136\u002Fpgmj.55.647.625",{"doi":533},{"id":23,"text":536,"url":23,"identifiers":537},"Jones D. B., 1980, Symposium on medical and surgical diseases of the cornea: Transactions of the New Orleans Academy of Ophthalmology, 86",{},{"id":23,"text":539,"url":23,"identifiers":540},"10.1016\u002F0002-9394(65)93413-6",{"doi":539},{"id":23,"text":542,"url":23,"identifiers":543},"Shadomy S., 1985, Manual of clinical microbiology, 991",{},{"id":23,"text":545,"url":23,"identifiers":546},"10.1093\u002Finfdis\u002F152.6.1249",{"doi":545},{"id":23,"text":548,"url":23,"identifiers":549},"10.1093\u002Fclinids\u002F9.Supplement_1.S43",{"doi":548},{"id":23,"text":551,"url":23,"identifiers":552},"10.1128\u002FAAC.26.4.527",{"doi":551},{"id":23,"text":554,"url":23,"identifiers":555},"10.1093\u002Fclinids\u002F9.Supplement_1.S15",{"doi":554},{"id":557,"createTime":558,"updateTime":559,"relativeEntities":560,"slug":561,"properties":562,"entityType":121,"verifyStatus":122,"verifyTime":558,"verifyNote":123,"languages":578,"translateLanguages":579,"viewCount":24,"primaryUrl":580,"fullTextUrl":23,"authors":581,"publicationType":223,"publisherRelationship":737,"citationCount":791,"citationInfo":792,"publishDate":795,"publishYear":793,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":796,"openAccess":23,"references":797,"isForceReanalyzing":353},"715d0960-ce18-40bb-8256-15422e03d1c9","2024-10-01T13:01:02.105+00:00","2025-02-23T01:44:12.636+00:00",[],"Pseudomembranous-and-obstructive-i-Aspergillus-i-tracheobronchitis-optimal-diagnostic-strategy-and-outcome",{"mag":563,"keywords":565,"openalex":566,"abstract":568,"title":571,"pm":574,"doi":576},{"VOID":564},"1986528608",{"VI":364},{"VOID":567},"W1986528608",{"EN":569,"VI":570},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Pseudomembranous and obstructive \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> tracheobronchitis (PMATB\u002FOATB) are still considered to be refractory to therapy and to have a fatal outcome. To evaluate the optimal diagnostic strategy and to describe factors affecting the outcome of PMATB and OATB. Retrospective analysis of four new cases of PMATB and OATB combined with 16 previously reported cases over a 10‐year period (1995–2004). Among the four new cases reported and the 16 published cases, four patients survived their infection. The mortality rate was significantly higher in the group of ventilated patients [94% (15 of 16 patients)] than in the group of non‐ventilated patients [25% (1 of 4 patients), \u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.05, Fisher's exact test]. In all 20 patients, diagnosis was established by bronchoscopy. Culture examination of mucous plugs was positive in 8 of 10, culture of the tracheobronchial aspirate was positive in 8 of 12, and bronchoalveolar lavage was diagnostic in 7 of 13 patients. All bronchoscopic techniques were complementary in improving the yield of bronchoscopy. However, microscopy of mucous plugs and\u002For necrotic material was the best diagnostic modality [positive in 94% (17 of 18 patients)]. Prognosis of PMATB and OATB remains poor. Microscopy of respiratory specimens is the most sensitive tool to confirm the diagnosis. The characteristic appearance of the disease makes it possible to start antifungal therapy immediately.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Tracheobronchitis giả màng và tắc nghẽn do \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> (PMATB\u002FOATB) vẫn được coi là khó điều trị và có thể dẫn đến tử vong. Mục tiêu của nghiên cứu này là đánh giá chiến lược chẩn đoán tối ưu và mô tả các yếu tố ảnh hưởng đến kết quả của PMATB và OATB. Phân tích hồi cứu bốn trường hợp PMATB và OATB mới kết hợp với 16 trường hợp đã được báo cáo trước đó trong khoảng thời gian 10 năm (1995–2004). Trong số bốn trường hợp mới báo cáo và 16 trường hợp đã công bố, có bốn bệnh nhân sống sót sau khi nhiễm bệnh. Tỷ lệ tử vong ở nhóm bệnh nhân thở máy là đáng kể hơn [94% (15 trên 16 bệnh nhân)] so với nhóm bệnh nhân không thở máy [25% (1 trên 4 bệnh nhân), \u003Cjats:italic>P\u003C\u002Fjats:italic> &lt 0.05, kiểm định chính xác Fisher]. Ở tất cả 20 bệnh nhân, chẩn đoán được thiết lập thông qua nội soi phế quản. Xét nghiệm nuôi cấy mảnh nhầy có kết quả dương tính trong 8 trên 10 trường hợp, nuôi cấy dịch rửa khí quản phế quản có kết quả dương tính trong 8 trên 12 trường hợp, và rửa phế quản phế nang có chẩn đoán trong 7 trên 13 bệnh nhân. Tất cả các kỹ thuật nội soi phế quản đều bổ sung cho nhau trong việc cải thiện tỷ lệ chẩn đoán của nội soi phế quản. Tuy nhiên, viễn thị mảnh nhầy và\u002Fhoặc vật liệu hoại tử là phương pháp chẩn đoán tốt nhất [dương tính trong 94% (17 trên 18 bệnh nhân)]. Tiên lượng cho PMATB và OATB vẫn kém. Viễn thị các mẫu bệnh phẩm đường hô hấp là công cụ nhạy nhất để xác nhận chẩn đoán. Đặc điểm hình thái của bệnh cho phép bắt đầu điều trị kháng nấm ngay lập tức.\u003C\u002Fjats:p>",{"EN":572,"VI":573},"Pseudomembranous and obstructive \u003Ci>Aspergillus\u003C\u002Fi> tracheobronchitis – optimal diagnostic strategy and outcome","Tracheobronchitis do \u003Ci>Aspergillus\u003C\u002Fi> giả màng và tắc nghẽn – chiến lược chẩn đoán tối ưu và kết quả",{"VOID":575},"16367817",{"VOID":577},"10.1111\u002Fj.1439-0507.2005.01180.x",[125],[380],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.2005.01180.x",[582,599,616,631,648,665,685,703,719],{"id":583,"sortIndex":24,"researcher":23,"roles":584,"affiliations":585,"properties":594,"displayName":596,"givenName":23,"familyName":23},"0d738e3a-eeaf-43fc-ac0c-8237ac880209",[],[586],{"id":587,"sortIndex":24,"affiliation":588,"properties":23},"a08ab480-2ba8-4cc5-81ed-a8e50d4ec98b",{"id":587,"createTime":23,"updateTime":23,"relativeEntities":589,"slug":23,"properties":590,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":593,"statistic":23},[],{"title":591},{"VI":592},"Department of Internal Medicine II",[],{"title":595,"openalex":597},{"EN":596},"Selçuk Tasci",{"VOID":598},"A5017118136",{"id":600,"sortIndex":147,"researcher":23,"roles":601,"affiliations":602,"properties":611,"displayName":613,"givenName":23,"familyName":23},"f60af5d1-a821-4b8c-a602-8abd9cd216a1",[],[603],{"id":604,"sortIndex":24,"affiliation":605,"properties":23},"c0e718e7-0187-4e05-a190-8e3ff4482fe0",{"id":604,"createTime":23,"updateTime":23,"relativeEntities":606,"slug":23,"properties":607,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":610,"statistic":23},[],{"title":608},{"VI":609},"Department of Internal Medicine I",[],{"title":612,"openalex":614},{"EN":613},"Axel Glasmacher",{"VOID":615},"A5065213472",{"id":617,"sortIndex":169,"researcher":23,"roles":618,"affiliations":619,"properties":626,"displayName":628,"givenName":23,"familyName":23},"a68ba163-448d-4c30-9d78-418a27e9b112",[],[620],{"id":587,"sortIndex":24,"affiliation":621,"properties":23},{"id":587,"createTime":23,"updateTime":23,"relativeEntities":622,"slug":23,"properties":623,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":625,"statistic":23},[],{"title":624},{"VI":592},[],{"title":627,"openalex":629},{"EN":628},"Silvia Lentini",{"VOID":630},"A5104729067",{"id":632,"sortIndex":189,"researcher":23,"roles":633,"affiliations":634,"properties":643,"displayName":645,"givenName":23,"familyName":23},"b4e823c7-4133-45e3-9bae-ff5b4cd1a3ff",[],[635],{"id":636,"sortIndex":24,"affiliation":637,"properties":23},"38b502fb-5dcf-421a-a35f-a4d5122d86be",{"id":636,"createTime":23,"updateTime":23,"relativeEntities":638,"slug":23,"properties":639,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":642,"statistic":23},[],{"title":640},{"EN":641},"Department of Pathology; University of Bonn; Bonn",[],{"title":644,"openalex":646},{"EN":645},"K. 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531",{},{"id":23,"text":838,"url":23,"identifiers":839},"10.1259\u002Fbjr.73.865.10721324",{"doi":838},{"id":23,"text":841,"url":23,"identifiers":842},"10.1093\u002Fndt\u002F14.7.1784",{"doi":841},{"id":23,"text":844,"url":23,"identifiers":845},"10.1038\u002Fsj.bmt.1702030",{"doi":844},{"id":23,"text":847,"url":23,"identifiers":848},"10.1086\u002F517666",{"doi":847},{"id":23,"text":850,"url":23,"identifiers":851},"10.1136\u002Fthx.50.7.807",{"doi":850},{"id":23,"text":853,"url":23,"identifiers":854},"10.1007\u002Fs001340000768",{"doi":853},{"id":23,"text":856,"url":23,"identifiers":857},"10.1164\u002Frccm.200401-093OC",{"doi":856},{"id":859,"createTime":860,"updateTime":861,"relativeEntities":862,"slug":863,"properties":864,"entityType":121,"verifyStatus":122,"verifyTime":880,"verifyNote":123,"languages":881,"translateLanguages":882,"viewCount":24,"primaryUrl":883,"fullTextUrl":23,"authors":884,"publicationType":223,"publisherRelationship":1007,"citationCount":1060,"citationInfo":1061,"publishDate":1063,"publishYear":503,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":1064,"openAccess":23,"references":1065,"isForceReanalyzing":353},"c423241d-4210-4567-83ab-1bfdf74bb86e","2024-10-02T06:35:10.446+00:00","2025-02-23T01:43:14.170+00:00",[],"The-Treatment-of-Aspergillosis-and-Aspergilloma-with-Itraconazole-Clinical-Results-of-an-Open-International-Study-1982-1987-Die-Behandlung-der-Aspergillose-und-des-Aspergilloms-mit-Itraconazol-Klinische-Ergebnisse-einer-offenen-internationalen-Studie-1982-1987-",{"mag":865,"keywords":867,"openalex":868,"abstract":870,"title":873,"pm":876,"doi":878},{"VOID":866},"2153515355",{"VI":364},{"VOID":869},"W2153515355",{"EN":871,"VI":872},"\u003Cjats:p>\u003Cjats:bold>Summary:\u003C\u002Fjats:bold>A total of 137 patients with aspergillosis or aspergilloma has been treated with 50 to 400 mg itraconazole daily during 11 to 780 days.\u003C\u002Fjats:p>\u003Cjats:p>The global assessments »markedly improved« and »cured« were given to 60% of the treatments in invasive aspergillosis (n = 35) and reached 66% in chronic necrotising pulmonary aspergillosis (n = 44). These response rates are sufficiently high regarding the limited number of antifungal agents useful in aspergillosis. Sixty‐two percent of the chronic pulmonary aspergilloma cases (n = 42) showed symptomatic improvement and the radiological picture had improved in 30%. In one patient, the fungus ball disappeared during long‐term treatment. The results in five allergic bronchopulmonary aspergillosis (ABPA) patients indicate a possible role for itraconazole as complementary treatment to corticosteroids. All seven patients with cutaneous aspergillosis were mycologically and clinically cured after a maximum of 158 days of treatment. Two out of three biopsy proven cases of bone aspergillosis responded to itraconazole therapy. These long‐term treatments with itraconazole were well tolerated. The reported side effects were merely of gastro‐intestinal origin and there was no effect on the most important biochemical and haematological parameters.\u003C\u002Fjats:p>\u003Cjats:p>Itraconazole appears to be a valuable new tool in the treatment of aspergillosis.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Zusammenfassung:\u003C\u002Fjats:bold>Eine Gesamtzahl von 137 Aspergillose‐ und Aspergillom‐Patienten wurde mit 50–400 mg Itraconazol täglich über Perioden zwischen 11 und 780 Tagen behandelt.\u003C\u002Fjats:p>\u003Cjats:p>Das Globalurteil »wesentlich gebessert« oder »geheilt« erhielten 60% der Behandelten mit invasiver Aspergillose (n = 35) und 66% der Patienten mit chronisch nekrotisierender Lungenaspergillose (n = 44). Diese Ansprechquoten sind recht hoch, wenn man die beschränkte Anzahl der bei Aspergillose wirksamen Antimykotika berücksichtigt. Bei 62% der Fälle mit chronischem Lungenaspergillom (n = 42) wurde eine symptomatische Besserung erzielt, bei 30% besserte sich das radiologische Bild. Bei einem Patienten verschwand der Fungusball während Langzeitbehandlung. Die Ergebnisse von 5 Patienten mit allergischer bronchopulmonaler Aspergilose (ABPA) deuten auf die mögliche Rolle von Itraconazol bei einer Kombinationsbehandlung mit Kortikosteroiden. Alle 7 Patienten mit kutaner Aspergillose waren nach einer maximalen Behandlungsdauer von 158 Tagen mykologisch und klinisch geheilt. Zwei von 3 bioptisch nachgewiesenen Fällen mit Knochenaspergillose sprachen auf Itraconazol‐Behandlung an. Die Langzeitbehandlung mit Itraconazol war gut verträglich. Die angegebenen Nebenwirkungen waren meist gastrointestinalen Ursprunges, die wesentlichsten biochemischen und hämatologischen Parameter blieben unbeeinflußt. Damit erweist sich Itraconazol als ein wertvolles neues Medikament bei der Behandlung der Aspergillose.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>Tóm tắt:\u003C\u002Fjats:bold>Tổng cộng có 137 bệnh nhân mắc bệnh aspergillosis hoặc aspergilloma đã được điều trị bằng Itraconazole liều 50 đến 400 mg mỗi ngày trong khoảng thời gian từ 11 đến 780 ngày.\u003C\u002Fjats:p>\u003Cjats:p>Các đánh giá tổng quát \"cải thiện đáng kể\" và \"được chữa khỏi\" đã được đưa ra cho 60% các trường hợp điều trị mắc aspergillosis xâm lấn (n = 35) và đạt 66% trong trường hợp aspergillosis phổi hoại tử mãn tính (n = 44). Tỷ lệ phản ứng này là khá cao xét về số lượng thuốc chống nấm hạn chế hữu ích trong việc điều trị aspergillosis. Sáu mươi hai phần trăm các trường hợp tổn thương phổi mãn tính do aspergilloma (n = 42) đã cho thấy sự cải thiện triệu chứng và hình ảnh học đã cải thiện ở 30%. Ở một bệnh nhân, khối nấm đã biến mất trong suốt quá trình điều trị dài hạn. Kết quả ở năm bệnh nhân mắc bệnh dị ứng phế quản phổi do aspergillosis (ABPA) cho thấy một vai trò có thể của Itraconazole như một liệu pháp bổ sung cho corticosteroid. Tất cả bảy bệnh nhân mắc bệnh aspergillosis da đã được chữa khỏi mycologically và lâm sàng sau tối đa 158 ngày điều trị. Hai trong số ba trường hợp đã được sinh thiết xem là có bệnh aspergillosis xương đã phản ứng tích cực với liệu pháp Itraconazole. Các liệu pháp điều trị dài hạn bằng Itraconazole đều được dung nạp tốt. Các tác dụng phụ được báo cáo chủ yếu có nguồn gốc từ đường tiêu hóa và không có tác động đến các chỉ số sinh hóa và huyết học quan trọng nhất.\u003C\u002Fjats:p>\u003Cjats:p>Itraconazole dường như là một công cụ mới có giá trị trong việc điều trị aspergillosis.\u003C\u002Fjats:p>",{"EN":874,"VI":875},"The Treatment of Aspergillosis and Aspergilloma with Itraconazole, Clinical Results of an Open International Study (1982 ‐ 1987)\u002FDie Behandlung der Aspergillose und des Aspergilloms mit Itraconazol, Klinische Ergebnisse einer offenen internationalen Studie (1982 ‐ 1987)","Điều trị Aspergillosis và Aspergilloma bằng Itraconazole, Kết quả lâm sàng của một Nghiên cứu Quốc tế Mở (1982 - 1987)",{"VOID":877},"2849056",{"VOID":879},"10.1111\u002Fj.1439-0507.1988.tb03653.x","2024-10-02T06:35:10.445+00:00",[125],[380],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.1988.tb03653.x",[885,902,917,932,947,962,977,992],{"id":886,"sortIndex":24,"researcher":23,"roles":887,"affiliations":888,"properties":897,"displayName":899,"givenName":23,"familyName":23},"4f8ed6df-9200-485b-a9db-3d5250f8802d",[],[889],{"id":890,"sortIndex":24,"affiliation":891,"properties":23},"a91400f1-891f-45d4-9746-427c5758567f",{"id":890,"createTime":23,"updateTime":23,"relativeEntities":892,"slug":23,"properties":893,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":896,"statistic":23},[],{"title":894},{"EN":895},"Janssen Research Foundation Worldwide, Beerse, Belgium",[],{"title":898,"openalex":900},{"EN":899},"K. 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A., 1987, Experience with itraconazole in deep mycoses in Northern Italy, Mykosen, 30, 23, 10.1111\u002Fj.1439-0507.1987.tb03973.x",{"doi":1096},"10.1111\u002Fj.1439-0507.1987.tb03973.x",{"id":23,"text":1098,"url":23,"identifiers":1099},"10.1007\u002F978-1-4899-3505-2_9",{"doi":1098},{"id":23,"text":1101,"url":23,"identifiers":1102},"Restrepo A., 1988, Aspergillus and aspergillosis, 252",{},{"id":23,"text":1104,"url":23,"identifiers":1105},"10.1007\u002F978-1-4899-3505-2_7",{"doi":1104},{"id":23,"text":1107,"url":23,"identifiers":1108},"10.1007\u002F978-1-4899-3505-2_4",{"doi":1107},{"id":1110,"createTime":1111,"updateTime":1112,"relativeEntities":1113,"slug":1114,"properties":1115,"entityType":121,"verifyStatus":122,"verifyTime":1111,"verifyNote":123,"languages":1132,"translateLanguages":1133,"viewCount":24,"primaryUrl":1134,"fullTextUrl":23,"authors":1135,"publicationType":223,"publisherRelationship":1230,"citationCount":1284,"citationInfo":1285,"publishDate":1288,"publishYear":1286,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":1289,"openAccess":23,"references":1290,"isForceReanalyzing":353},"f0c22510-aae2-4fbe-be8f-8b92d0d6a93a","2024-10-02T06:33:17.848+00:00","2025-02-23T01:42:14.622+00:00",[],"Antifungal-Prophylaxis-with-Itraconazole-in-Prolonged-Neutropenia-Correlation-with-Plasma-Levels",{"mag":1116,"keywords":1118,"openalex":1120,"abstract":1122,"title":1125,"pm":1128,"doi":1130},{"VOID":1117},"2020985135",{"VI":1119},"itraconazole, dự phòng nấm, nhiễm trùng nấm, giảm bạch cầu, bệnh lý huyết học",{"VOID":1121},"W2020985135",{"EN":1123,"VI":1124},"\u003Cjats:p>\u003Cjats:bold>Summary: \u003C\u002Fjats:bold> Seventy‐two patients with haematological malignancies were treated prophylactically with itraconazole during remission induction therapy.\u003C\u002Fjats:p>\u003Cjats:p>The incidence of proven fungal infections was 18 %, of which 12.5 % were fatal. \u003Cjats:italic>Aspergillus, Tomlopsis\u003C\u002Fjats:italic> and \u003Cjats:italic>Candida\u003C\u002Fjats:italic> proved to be major invasive pathogens. Plasma levels of itraconazole were monitored for all patients.\u003C\u002Fjats:p>\u003Cjats:p>The occurrence of fungal infection is significantly greater in the group where no therapeutic plasma levels were obtained during at least two weeks.\u003C\u002Fjats:p>\u003Cjats:p>There is a clear need to obtain quick information on itraconazole plasma levels in order to adapt dosage during prophylactic treatment in immunocompromised patients.\u003C\u002Fjats:p>\u003Cjats:p>The influence of itraconazole on liver function tests could not be separated from concomitant cytostatic or antibiotic treatment. No jaundice directly related to itraconazole could be found.\u003C\u002Fjats:p>\u003Cjats:p>During itraconazole prophylaxis a shift from classic pathogens such as \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> and \u003Cjats:italic>Candida, to Fusarium, Torulopsis\u003C\u002Fjats:italic> and \u003Cjats:italic>Mucor\u003C\u002Fjats:italic>, may be seen.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>Tóm tắt: \u003C\u002Fjats:bold> Bảy mươi hai bệnh nhân mắc các bệnh lý huyết học đã được điều trị dự phòng bằng itraconazole trong quá trình điều trị khởi phát khả năng hồi phục.\u003C\u002Fjats:p>\u003Cjats:p>Tỷ lệ xảy ra nhiễm trùng nấm đã được xác định là 18%, trong đó 12.5% là tử vong. \u003Cjats:italic>Aspergillus, Tomlopsis\u003C\u002Fjats:italic> và \u003Cjats:italic>Candida\u003C\u002Fjats:italic> đã được chứng minh là các tác nhân xâm lấn chính. Nồng độ itraconazole trong huyết thanh đã được theo dõi ở tất cả bệnh nhân.\u003C\u002Fjats:p>\u003Cjats:p>Sự xuất hiện của nhiễm trùng nấm cao hơn đáng kể ở nhóm không đạt được nồng độ huyết thanh điều trị trong ít nhất hai tuần.\u003C\u002Fjats:p>\u003Cjats:p>Có một nhu cầu rõ ràng về việc nhanh chóng thu thập thông tin về nồng độ itraconazole trong huyết thanh để điều chỉnh liều lượng trong điều trị dự phòng cho các bệnh nhân suy giảm miễn dịch.\u003C\u002Fjats:p>\u003Cjats:p>Ảnh hưởng của itraconazole đến các xét nghiệm chức năng gan không thể tách rời khỏi việc điều trị đồng thời bằng hóa trị liệu hoặc kháng sinh. Không có dấu hiệu vàng da nào được tìm thấy mà có liên quan trực tiếp đến itraconazole.\u003C\u002Fjats:p>\u003Cjats:p>Trong suốt giai đoạn dự phòng bằng itraconazole, có thể thấy sự chuyển dịch từ các tác nhân gây bệnh cổ điển như \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> và \u003Cjats:italic>Candida\u003C\u002Fjats:italic> sang \u003Cjats:italic>Fusarium, Torulopsis\u003C\u002Fjats:italic> và \u003Cjats:italic>Mucor\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>",{"EN":1126,"VI":1127},"Antifungal Prophylaxis with Itraconazole in Prolonged Neutropenia: Correlation with Plasma Levels","Dự Phòng Nấm Dựa Trên Itraconazole Trong Tình Trạng Giảm Bạch Cầu Kéo Dài: Mối Liên Hệ Với Nồng Độ Trong Huyết Thanh",{"VOID":1129},"2561181",{"VOID":1131},"10.1111\u002Fj.1439-0507.1989.tb02299.x",[125],[380],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.1989.tb02299.x",[1136,1153,1168,1185,1200,1215],{"id":1137,"sortIndex":24,"researcher":23,"roles":1138,"affiliations":1139,"properties":1148,"displayName":1150,"givenName":23,"familyName":23},"c8716c6c-d5ca-4230-ba61-8392a71d51cb",[],[1140],{"id":1141,"sortIndex":24,"affiliation":1142,"properties":23},"37cedfd4-15ba-42b0-8e14-7b8e82c32a80",{"id":1141,"createTime":23,"updateTime":23,"relativeEntities":1143,"slug":23,"properties":1144,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":1147,"statistic":23},[],{"title":1145},{"EN":1146},"University Hospital, Hematology, Microbiology, Leuven, Belgium",[],{"title":1149,"openalex":1151},{"EN":1150},"Marc Boogaerts",{"VOID":1152},"A5062839406",{"id":1154,"sortIndex":147,"researcher":23,"roles":1155,"affiliations":1156,"properties":1163,"displayName":1165,"givenName":23,"familyName":23},"cb20e4bf-6ea6-492c-a5da-eecf71adc428",[],[1157],{"id":1141,"sortIndex":24,"affiliation":1158,"properties":23},{"id":1141,"createTime":23,"updateTime":23,"relativeEntities":1159,"slug":23,"properties":1160,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":1162,"statistic":23},[],{"title":1161},{"EN":1146},[],{"title":1164,"openalex":1166},{"EN":1165},"G. 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ICAAC, 210",{},{"id":23,"text":1302,"url":23,"identifiers":1303},"10.7326\u002F0003-4819-100-3-345",{"doi":1302},{"id":23,"text":1084,"url":23,"identifiers":1305},{"doi":1086},{"id":23,"text":1307,"url":23,"identifiers":1308},"10.1093\u002Fclinids\u002F9.Supplement_1.S94",{"doi":1307},{"id":23,"text":551,"url":23,"identifiers":1310},{"doi":551},{"id":1312,"createTime":1313,"updateTime":1314,"relativeEntities":1315,"slug":1316,"properties":1317,"entityType":121,"verifyStatus":22,"verifyTime":1313,"verifyNote":1334,"languages":1335,"translateLanguages":1336,"viewCount":24,"primaryUrl":1337,"fullTextUrl":23,"authors":1338,"publicationType":223,"publisherRelationship":1376,"citationCount":1430,"citationInfo":1431,"publishDate":1442,"publishYear":1432,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":1443,"openAccess":23,"references":1444,"isForceReanalyzing":353},"c6596fdc-4428-4e05-ab80-32d86bf92a99","2024-09-11T10:59:33.565+00:00","2025-02-23T01:41:17.607+00:00",[],"-i-Aspergillus-flavus-i-an-emerging-non-i-fumigatus-Aspergillus-i-species-of-significance",{"mag":1318,"keywords":1320,"openalex":1322,"abstract":1324,"title":1327,"pm":1330,"doi":1332},{"VOID":1319},"2069723009",{"VI":1321},"Aspergillus flavus, aspergillosis xâm lấn, vi sinh vật học, độc tính, dịch tễ học",{"VOID":1323},"W2069723009",{"EN":1325,"VI":1326},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Invasive aspergillosis is rare in immunocompetent people but contributes to significant morbidity and mortality in immunosuppressed patients. The majority (approximately 80%) of invasive Aspergillus infections is caused by \u003Cjats:italic>Aspergillus fumigatus\u003C\u002Fjats:italic>. The second most frequent (approximately 15–20%) pathogenic species is \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> and to a lesser extent, \u003Cjats:italic>Aspergillus niger\u003C\u002Fjats:italic> and \u003Cjats:italic>Aspergillus terreus\u003C\u002Fjats:italic>. \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> has emerged as a predominant pathogen in patients with fungal sinusitis and fungal keratitis in several institutions worldwide. To date, there has not been any publication exclusively reviewing the topic of \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> in the literature. This article reviews the microbiology, toxigenicity and epidemiology of \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> as well as describes the clinical characteristics, diagnosis and management of infections caused by this organism.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Bệnh aspergillosis xâm lấn rất hiếm gặp ở những người có hệ miễn dịch bình thường nhưng góp phần gây ra tỷ lệ bệnh tật và tử vong đáng kể ở những bệnh nhân suy giảm miễn dịch. Phần lớn (khoảng 80%) các ca nhiễm nấm \u003Ci>Aspergillus\u003C\u002Fi> xâm lấn là do \u003Cjats:italic>Aspergillus fumigatus\u003C\u002Fjats:italic> gây ra. Loài gây bệnh phổ biến thứ hai (khoảng 15-20%) là \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic>, và một phần nhỏ hơn là \u003Cjats:italic>Aspergillus niger\u003C\u002Fjats:italic> và \u003Cjats:italic>Aspergillus terreus\u003C\u002Fjats:italic>. \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> đã xuất hiện như một tác nhân chủ yếu ở những bệnh nhân bị viêm xoang nấm và viêm giác mạc nấm tại một số cơ sở y tế trên toàn thế giới. Đến nay, chưa có công bố nào độc quyền xem xét chủ đề về \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> trong tài liệu. Bài báo này xem xét về vi sinh vật học, độc tính và dịch tễ học của \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> cũng như mô tả các đặc điểm lâm sàng, chẩn đoán và quản lý các nhiễm trùng do loại sinh vật này gây ra.\u003C\u002Fjats:p>",{"EN":1328,"VI":1329},"\u003Ci>Aspergillus flavus\u003C\u002Fi>: an emerging non‐\u003Ci>fumigatus Aspergillus\u003C\u002Fi> species of significance","\u003Ci>Aspergillus flavus\u003C\u002Fi>: một loài \u003Ci>Aspergillus\u003C\u002Fi> không phải \u003Ci>fumigatus\u003C\u002Fi> đang nổi lên với tầm quan trọng",{"VOID":1331},"19207851",{"VOID":1333},"10.1111\u002Fj.1439-0507.2008.01642.x","Author affiliation is blank",[125],[380],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.2008.01642.x",[1339,1356,1365],{"id":1340,"sortIndex":24,"researcher":23,"roles":1341,"affiliations":1342,"properties":1351,"displayName":1353,"givenName":23,"familyName":23},"87b57a07-81de-469d-9868-5dc00e91b978",[],[1343],{"id":1344,"sortIndex":24,"affiliation":1345,"properties":23},"dea9c52a-2854-4ebe-a4a7-60b4d050e55b",{"id":1344,"createTime":23,"updateTime":23,"relativeEntities":1346,"slug":23,"properties":1347,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":1350,"statistic":23},[],{"title":1348},{"EN":1349},"Division of Infectious Diseases, Wayne State University, John D. Dingell VA Medical Center, Detroit, MI 48201, USA. skrishn@med.wayne.edu",[],{"title":1352,"openalex":1354},{"EN":1353},"Suganthini Krishnan",{"VOID":1355},"A5051900505",{"id":1357,"sortIndex":147,"researcher":23,"roles":1358,"affiliations":1359,"properties":1360,"displayName":1362,"givenName":23,"familyName":23},"90b759c9-c28b-4843-8167-2c8046276fb1",[],[],{"title":1361,"openalex":1363},{"EN":1362},"Elias K. Manavathu",{"VOID":1364},"A5006537567",{"id":1366,"sortIndex":169,"researcher":23,"roles":1367,"affiliations":1368,"properties":1369,"displayName":1373,"givenName":23,"familyName":23},"f1b028fc-74f7-43b9-93a0-682d7ae77cab",[],[],{"orcid":1370,"title":1372,"openalex":1374},{"VOID":1371},"https:\u002F\u002Forcid.org\u002F0000-0003-0774-1058",{"EN":1373},"Pranatharthi Chandrasekar",{"VOID":1375},"A5001375492",{"url":23,"publisher":1377,"properties":1423},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1378,"slug":10,"properties":1379,"entityType":21,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":24,"subjectFields":1384,"manageAffiliations":1397,"indexDatabases":1408,"url":97,"thumbnailPath":23,"statistic":23,"gsStatistic":23,"type":23,"analyzePriority":23},[],{"country":1380,"eissn":1381,"issn":1382,"title":1383},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":10},[1385,1389,1393],{"id":27,"createTime":23,"updateTime":23,"relativeEntities":1386,"label":1387,"description":1388,"parentId":23,"standard":23,"scholarHubFieldId":23},[],{"EN":30},{},{"id":33,"createTime":23,"updateTime":23,"relativeEntities":1390,"label":1391,"description":1392,"parentId":23,"standard":23,"scholarHubFieldId":23},[],{"EN":36},{},{"id":39,"createTime":23,"updateTime":23,"relativeEntities":1394,"label":1395,"description":1396,"parentId":23,"standard":23,"scholarHubFieldId":23},[],{"EN":42},{},[1398,1403],{"id":46,"createTime":23,"updateTime":23,"relativeEntities":1399,"slug":23,"properties":1400,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":1402,"statistic":23},[],{"title":1401},{"EN":50},[],{"id":53,"createTime":23,"updateTime":23,"relativeEntities":1404,"slug":23,"properties":1405,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":1407,"statistic":23},[],{"title":1406},{"EN":57},[],[1409,1416],{"id":61,"indexDatabase":1410,"url":74,"indexYears":23,"academicFieldIds":1415,"indexDatabaseRanking":23},{"id":63,"createTime":23,"updateTime":23,"relativeEntities":1411,"label":1412,"description":1413,"key":70,"publicationTags":1414,"standard":23},[],{"EN":66,"VI":66},{"EN":68,"VI":69},[72,73],[76,77],{"id":79,"indexDatabase":1417,"url":90,"indexYears":91,"academicFieldIds":1422,"indexDatabaseRanking":96},{"id":81,"createTime":23,"updateTime":23,"relativeEntities":1418,"label":1419,"description":1420,"key":87,"publicationTags":1421,"standard":23},[],{"EN":84,"VI":84},{"EN":84,"VI":86},[89],[93,94,95],{"issue":1424,"pages":1426,"volume":1428},{"VOID":1425},"3",{"VOID":1427},"206-222",{"VOID":1429},"52",235,{"total":1430,"publishYear":1432,"statisticByYear":1433},2009,{"2012":1434,"2013":1435,"2014":1436,"2015":721,"2016":1437,"2017":1438,"2018":1434,"2019":1439,"2020":1436,"2021":1436,"2022":1437,"2023":1440,"2024":1441},13,18,14,24,11,19,16,15,"2009-05-01",[96,72],[1445,1449,1452,1455,1458,1461,1465,1468,1471,1474,1477,1480,1484,1487,1491,1494,1497,1500,1503,1506,1509,1512,1515,1518,1521,1524,1527,1530,1533,1536,1539,1542,1545,1548,1552,1555,1559,1562,1565,1568,1571,1574,1577,1580,1583,1586,1589,1592,1595,1598,1601,1604,1607,1611,1614,1617,1620,1623,1626,1630,1633,1636,1639,1642,1645,1648,1651,1654,1657,1660,1663,1666,1669,1672,1675,1678,1681,1684,1687,1690,1693,1696,1699,1702,1705,1708,1711,1714,1717,1720,1723,1726,1729,1732,1735,1738,1741,1743,1746,1749,1752,1755,1758,1761,1764,1767,1770,1773,1776,1779,1782,1785,1788,1791,1794,1797,1800,1803,1806,1809,1812,1815,1818,1821,1824,1827,1830,1833,1836,1839,1842,1845,1848,1851,1854,1857,1860,1863,1866,1869,1872,1875,1878,1881,1884,1887,1890,1893,1896,1899,1902,1905,1908,1911,1914,1917,1920,1923,1927,1930,1933,1936,1939,1942,1945,1948,1951,1954,1957,1961,1965,1968,1970,1973,1976,1979,1982,1985,1988,1991,1994,1997,2000,2003,2005,2007,2010,2013,2016,2019,2022,2025,2028,2031,2033,2036,2039,2042,2045,2048,2051,2054,2057,2060,2063,2066,2069,2072,2075,2078,2081,2084,2087,2090],{"id":23,"text":1446,"url":23,"identifiers":1447},"Corrall 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10.1177\u002F019459988910700606.1",{"doi":1464},"10.1177\u002F019459988910700606.1",{"id":23,"text":1466,"url":23,"identifiers":1467},"10.1016\u002FS0161-6420(03)00861-3",{"doi":1466},{"id":23,"text":1469,"url":23,"identifiers":1470},"10.1097\u002F00003226-200110000-00009",{"doi":1469},{"id":23,"text":1472,"url":23,"identifiers":1473},"10.1016\u002FS0002-9394(00)00406-2",{"doi":1472},{"id":23,"text":1475,"url":23,"identifiers":1476},"10.1097\u002F00003226-200301000-00020",{"doi":1475},{"id":23,"text":1478,"url":23,"identifiers":1479},"10.1097\u002F01.inf.0000157218.37603.84",{"doi":1478},{"id":23,"text":1481,"url":23,"identifiers":1482},"Hetherington SV, 1994, Monoclonal antibodies against a 97‐kilodalton antigen from Aspergillus flavus, Clin Diagn Lab Immunol, 1, 63, 10.1128\u002Fcdli.1.1.63-67.1994",{"doi":1483},"10.1128\u002Fcdli.1.1.63-67.1994",{"id":23,"text":1485,"url":23,"identifiers":1486},"Sutton DA, 1998, Guide to Clinically Significant Fungi",{},{"id":23,"text":1488,"url":23,"identifiers":1489},"Sommer NF, 1976, Aflatoxin and sterigmatocystin contamination of pistachio nuts in orchards, Appl Environ Microbiol, 32, 64, 10.1128\u002Faem.32.1.64-67.1976",{"doi":1490},"10.1128\u002Faem.32.1.64-67.1976",{"id":23,"text":1492,"url":23,"identifiers":1493},"Desai MR, 2003, Occupational exposure to airborne fungi among rice mill workers with special reference to aflatoxin producing A. flavus strains, Ann Agric Environ Med, 10, 159",{},{"id":23,"text":1495,"url":23,"identifiers":1496},"10.1016\u002FS0168-1605(02)00539-1",{"doi":1495},{"id":23,"text":1498,"url":23,"identifiers":1499},"Desai MR, 2003, Aflatoxin related occupational exposure to maize processing workers, Cell Mol Biol (Noisy-le-grand), 49, 529",{},{"id":23,"text":1501,"url":23,"identifiers":1502},"10.4315\u002F0362-028X-67.1.96",{"doi":1501},{"id":23,"text":1504,"url":23,"identifiers":1505},"10.4315\u002F0362-028X-67.1.90",{"doi":1504},{"id":23,"text":1507,"url":23,"identifiers":1508},"10.1016\u002FS0160-4120(03)00103-X",{"doi":1507},{"id":23,"text":1510,"url":23,"identifiers":1511},"Valenton M, 1996, Wound infection after cataract surgery, Jpn J Ophthalmol, 40, 447",{},{"id":23,"text":1513,"url":23,"identifiers":1514},"10.1016\u002Fj.jhin.2004.02.007",{"doi":1513},{"id":23,"text":1516,"url":23,"identifiers":1517},"10.1007\u002FBF01259400",{"doi":1516},{"id":23,"text":1519,"url":23,"identifiers":1520},"10.1001\u002Fjama.284.22.2869",{"doi":1519},{"id":23,"text":1522,"url":23,"identifiers":1523},"Hube B, 1996, Candida albicans secreted aspartyl proteinases, Curr Top Med Mycol, 7, 55",{},{"id":23,"text":1525,"url":23,"identifiers":1526},"10.1128\u002FMMBR.67.3.400-428.2003",{"doi":1525},{"id":23,"text":1528,"url":23,"identifiers":1529},"Yang YL, 2003, Virulence factors of Candida albicans, J Microbiol Immunol Infect, 36, 223",{},{"id":23,"text":1531,"url":23,"identifiers":1532},"10.1016\u002FS1567-1356(03)00205-8",{"doi":1531},{"id":23,"text":1534,"url":23,"identifiers":1535},"10.1016\u002Fj.femsle.2005.02.015",{"doi":1534},{"id":23,"text":1537,"url":23,"identifiers":1538},"10.1016\u002F0732-8893(90)90081-6",{"doi":1537},{"id":23,"text":1540,"url":23,"identifiers":1541},"10.1099\u002Fjmm.0.05248-0",{"doi":1540},{"id":23,"text":1543,"url":23,"identifiers":1544},"10.1159\u002F000024205",{"doi":1543},{"id":23,"text":1546,"url":23,"identifiers":1547},"10.1016\u002F0732-8893(88)90036-3",{"doi":1546},{"id":23,"text":1549,"url":23,"identifiers":1550},"Ramesh MV, 1994, Isolation, characterization, and cloning of cDNA and the gene for an elastinolytic serine proteinase from Aspergillus flavus, Infect Immun, 62, 79, 10.1128\u002Fiai.62.1.79-85.1994",{"doi":1551},"10.1128\u002Fiai.62.1.79-85.1994",{"id":23,"text":1553,"url":23,"identifiers":1554},"10.1006\u002Fbbrc.1999.1093",{"doi":1553},{"id":23,"text":1556,"url":23,"identifiers":1557},"Ramesh MV, 1996, Disruption of the serine proteinase gene (sep) in Aspergillus flavus leads to a compensatory increase in the expression of a metalloproteinase gene (mep20), J Bacteriol, 178, 3899, 10.1128\u002Fjb.178.13.3899-3907.1996",{"doi":1558},"10.1128\u002Fjb.178.13.3899-3907.1996",{"id":23,"text":1560,"url":23,"identifiers":1561},"10.1078\u002F1438-4221-00223",{"doi":1560},{"id":23,"text":1563,"url":23,"identifiers":1564},"Pavlukova EB, 1998, Extracellular proteolytic enzymes of filamentous fungi, Biochemistry (Mosc), 63, 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PE, 1993, Evidence for possible involvement of an elastolytic serine protease in aspergillosis, Infect Immun, 61, 2357, 10.1128\u002Fiai.61.6.2357-2368.1993",{"doi":1610},"10.1128\u002Fiai.61.6.2357-2368.1993",{"id":23,"text":1612,"url":23,"identifiers":1613},"10.1080\u002F02681219480000301",{"doi":1612},{"id":23,"text":1615,"url":23,"identifiers":1616},"10.3109\u002F01902149809041532",{"doi":1615},{"id":23,"text":1618,"url":23,"identifiers":1619},"10.1046\u002Fj.1439-0507.2000.00586.x",{"doi":1618},{"id":23,"text":1621,"url":23,"identifiers":1622},"10.1183\u002F09031936.98.12030607",{"doi":1621},{"id":23,"text":1624,"url":23,"identifiers":1625},"10.1007\u002Fs002849910048",{"doi":1624},{"id":23,"text":1627,"url":23,"identifiers":1628},"Rhodes JC, 1990, Isolation and characterization of an elastinolytic proteinase from Aspergillus flavus, Infect Immun, 58, 2529, 10.1128\u002Fiai.58.8.2529-2534.1990",{"doi":1629},"10.1128\u002Fiai.58.8.2529-2534.1990",{"id":23,"text":1631,"url":23,"identifiers":1632},"10.1080\u002F02681219180000641",{"doi":1631},{"id":23,"text":1634,"url":23,"identifiers":1635},"10.1016\u002F0378-1119(95)00434-8",{"doi":1634},{"id":23,"text":1637,"url":23,"identifiers":1638},"10.1111\u002Fj.1365-280X.1998.00124.x",{"doi":1637},{"id":23,"text":1640,"url":23,"identifiers":1641},"10.1128\u002Fiai.65.12.5110-5117.1997",{"doi":1640},{"id":23,"text":1643,"url":23,"identifiers":1644},"10.1007\u002Fs00284-002-3948-6",{"doi":1643},{"id":23,"text":1646,"url":23,"identifiers":1647},"10.1016\u002FS0300-483X(99)00023-2",{"doi":1646},{"id":23,"text":1649,"url":23,"identifiers":1650},"10.1128\u002FJCM.37.4.1221-1223.1999",{"doi":1649},{"id":23,"text":1652,"url":23,"identifiers":1653},"10.1016\u002F0192-0561(94)90076-0",{"doi":1652},{"id":23,"text":1655,"url":23,"identifiers":1656},"Bis WA, 1990, Studies of immunological activity of Aspergillus flavus Link III. Presence of antibodies against fungal antigens in the sera of persons from selected groups, Med Dosw Mikrobiol, 42, 156",{},{"id":23,"text":1658,"url":23,"identifiers":1659},"Bis WA, 1990, Study of immunological activity of Aspergillus flavus Link II. 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tắt\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:italic>Đại diện phức tạp \u003Ci>Cryptococcus gattii\u003C\u002Fi>\u003C\u002Fjats:italic> đã trở thành một tác nhân gây bệnh trong hai thập kỷ qua, gây nhiễm trùng ở cả những người có hệ miễn dịch khỏe mạnh và những người có hệ miễn dịch suy yếu. Chúng tôi đã tiến hành phân tích các đặc điểm lâm sàng của nhiễm trùng \u003Cjats:styled-content style=\"fixed-case\">CNS\u003C\u002Fjats:styled-content> do \u003Cjats:italic>C. gattii sensu lato\u003C\u002Fjats:italic>, hồ sơ phân tử và độ nhạy với thuốc chống nấm của tác nhân này. Các trường hợp được chẩn đoán mắc bệnh \u003Cjats:styled-content style=\"fixed-case\">CNS\u003C\u002Fjats:styled-content> cryptococcosis đã được đưa vào nghiên cứu. \u003Cjats:italic>Cryptococcus\u003C\u002Fjats:italic> được thu hồi từ mẫu bệnh phẩm của bệnh nhân đã được xác định theo quy trình chuẩn. Xác nhận loài, xác định kiểu giao phối và kiểu phân tử được thực hiện thông qua các phương pháp dựa trên \u003Cjats:styled-content style=\"fixed-case\">PCR\u003C\u002Fjats:styled-content>. Độ nhạy với thuốc chống nấm được thử nghiệm bằng \u003Cjats:styled-content style=\"fixed-case\">VITEK\u003C\u002Fjats:styled-content>2C đối với amphotericin B, 5‐flucytosine, fluconazole và voriconazole. Trong số 199 trường hợp, 20 (10%) là do \u003Cjats:italic>C. gattii\u003C\u002Fjats:italic>, bao gồm 75% trường hợp viêm màng não cryptococcal và 25% trường hợp cryptococcoma. Nam giới trưởng thành trẻ tuổi là nhóm bị ảnh hưởng phổ biến. Đau đầu và buồn nôn là các triệu chứng nổi bật và 50% bệnh nhân có hệ miễn dịch suy yếu. Trong số các mẫu phân lập, 75%, 20% và 5% lần lượt là \u003Cjats:italic>C. tetragattii, C. gattii sensu stricto\u003C\u002Fjats:italic> và \u003Cjats:italic>C. bacillisporus\u003C\u002Fjats:italic>, và tất cả đều có kiểu giao phối α. Bốn (20%) mẫu phân lập của \u003Cjats:italic>C. tetragattii\u003C\u002Fjats:italic> và mẫu phân lập duy nhất của \u003Cjats:italic>C. bacillisporus\u003C\u002Fjats:italic> đều kháng fluconazole. Loài phổ biến nhất được phân lập từ miền Nam Ấn Độ là \u003Cjats:italic>C. tetragattii\u003C\u002Fjats:italic>. Nghiên cứu này đóng góp vào dịch tễ học của \u003Cjats:italic>C. gattii\u003C\u002Fjats:italic> và nhấn mạnh sự cần thiết của việc phân loại gen và thử nghiệm độ nhạy với thuốc chống nấm.\u003C\u002Fjats:p>","\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:italic>Cryptococcus gattii\u003C\u002Fjats:italic> species complex has evolved as a pathogen in the last two decades causing infection among both immunocompetent and immunocompromised hosts. We aimed to analyse the clinical features of \u003Cjats:styled-content style=\"fixed-case\">CNS\u003C\u002Fjats:styled-content> infection caused by \u003Cjats:italic>C. gattii sensu lato\u003C\u002Fjats:italic>, molecular and antifungal susceptibility profile of this pathogen. Cases diagnosed to have \u003Cjats:styled-content style=\"fixed-case\">CNS\u003C\u002Fjats:styled-content> cryptococcosis were included in the study. \u003Cjats:italic>Cryptococcus\u003C\u002Fjats:italic> recovered from patient's specimen was identified by standard protocol. Species confirmation, mating type and molecular type determination were performed by \u003Cjats:styled-content style=\"fixed-case\">PCR\u003C\u002Fjats:styled-content> based methods. Antifungal susceptibility was tested in \u003Cjats:styled-content style=\"fixed-case\">VITEK\u003C\u002Fjats:styled-content>2C to amphotericin B, 5‐flucytosine, fluconazole and voriconazole. Among 199 cases, 20 (10%) were due to \u003Cjats:italic>C. gattii\u003C\u002Fjats:italic>, comprising of 75% cryptococcal meningitis and 25% cryptococcoma cases. Young adult males were commonly affected. Headache and vomiting were prominent symptoms and 50% were immunocompromised. Among the isolates, 75%, 20% and 5% were \u003Cjats:italic>C. tetragattii, C. gattii sensu stricto\u003C\u002Fjats:italic> and \u003Cjats:italic>C. bacillisporus\u003C\u002Fjats:italic> respectively and all had mating type α. Four (20%) isolates of \u003Cjats:italic>C. tetragattii\u003C\u002Fjats:italic> and the only isolate of \u003Cjats:italic>C. bacillisporus\u003C\u002Fjats:italic> were resistant to fluconazole. The most common species isolated from south India is \u003Cjats:italic>C. tetragattii\u003C\u002Fjats:italic>. The study contributes to the epidemiology of \u003Cjats:italic>C. gattii\u003C\u002Fjats:italic> and reiterates the need for genotyping and antifungal susceptibility testing.\u003C\u002Fjats:p>",{"EN":2109,"VI":2110},"Central nervous system infection due to \u003Ci>Cryptococcus gattii sensu lato\u003C\u002Fi> in India: Analysis of clinical features, molecular profile and antifungal susceptibility","Nhiễm trùng hệ thần kinh trung ương do \u003Ci>Cryptococcus gattii sensu lato\u003C\u002Fi> tại Ấn Độ: Phân tích các đặc điểm lâm sàng, hồ sơ phân tử và độ nhạy với thuốc chống n nấm",{"VOID":2112},"28736880",{"VOID":2114},"10.1111\u002Fmyc.12656",[125],[380],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fmyc.12656",[2119,2138,2153,2172,2189,2204,2223,2238],{"id":2120,"sortIndex":24,"researcher":23,"roles":2121,"affiliations":2122,"properties":2131,"displayName":2135,"givenName":23,"familyName":23},"0f7dfb05-23ce-44a6-a091-0405ca22080b",[],[2123],{"id":2124,"sortIndex":24,"affiliation":2125,"properties":23},"3917c458-3ce1-4a1e-95a7-f2b0830ec5bb",{"id":2124,"createTime":23,"updateTime":23,"relativeEntities":2126,"slug":23,"properties":2127,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":2130,"statistic":23},[],{"title":2128},{"VI":2129},"Department of Neuromicrobiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India",[],{"orcid":2132,"title":2134,"openalex":2136},{"VOID":2133},"https:\u002F\u002Forcid.org\u002F0000-0001-6918-2269",{"EN":2135},"Shayanki Lahiri",{"VOID":2137},"A5045930434",{"id":2139,"sortIndex":147,"researcher":23,"roles":2140,"affiliations":2141,"properties":2148,"displayName":2150,"givenName":23,"familyName":23},"ee657109-771b-4f35-9e63-956353643963",[],[2142],{"id":2124,"sortIndex":24,"affiliation":2143,"properties":23},{"id":2124,"createTime":23,"updateTime":23,"relativeEntities":2144,"slug":23,"properties":2145,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":2147,"statistic":23},[],{"title":2146},{"VI":2129},[],{"title":2149,"openalex":2151},{"EN":2150},"Veenakumari H. 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tắt\u003C\u002Fjats:title>\u003Cjats:p>Các proteinase aspartyl được tiết ra (Saps) của \u003Cjats:italic>Candida albicans\u003C\u002Fjats:italic> đã được xác định là các kháng nguyên miễn dịch áp đảo và yếu tố virulence liên quan đến khả năng bám dính và xâm nhập vào mô. Một phage lai hiển thị epitop Sap VKYTS đã được chế tạo bằng cách nhân bản các đoạn DNA tương ứng vào vec tơ pfd88. Tương tự như Sap bản địa, epitop được hiển thị bởi phage đã cho thấy khả năng phản ứng với huyết thanh từ chuột và bệnh nhân bị nhiễm \u003Cjats:italic>C. albicans\u003C\u002Fjats:italic> hệ thống, nhưng không phản ứng với những người mắc bệnh nấm miệng họng và những cá nhân khỏe mạnh trong thử nghiệm Western blot. Hơn nữa, một xét nghiệm miễn dịch liên kết enzyme mới đã được phát triển để phát hiện kháng thể chống Sap với phage lai hiển thị epitop Sap VKYTS mà có thể được nhận biết bởi các kháng thể chống Sap. Huyết thanh mẫu thu được tuần tự từ bệnh nhân và chuột mắc bệnh nấm toàn thân và nấm miệng họng, cũng như mẫu huyết thanh từ những cá nhân khỏe mạnh cũng đã được đưa vào nghiên cứu. Độ nhạy và độ đặc hiệu lần lượt là 77% và 88.3% đối với chuột thí nghiệm. Các giá trị này đạt 60% và 85% đối với bệnh nhân người. Những dữ liệu này cho thấy epitop được hiển thị bằng phage này như một tá chất hiệu quả và ít tốn kém sẽ là một công cụ quý giá để phát hiện kháng thể cụ thể đối với Sap trong huyết thanh của bệnh nhân và chuột bị nhiễm \u003Cjats:italic>C. albicans\u003C\u002Fjats:italic> hệ thống.\u003C\u002Fjats:p>","\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>The secreted aspartyl proteinases (Saps) of \u003Cjats:italic>Candida albicans\u003C\u002Fjats:italic> have been implicated as immunodominant antigens and virulence factors associated with adherence and tissue invasion. A hybrid phage displaying the Sap epitope VKYTS was constructed by cloning the corresponding DNA fragments into the pfd88 vector. Similar to native Sap, the phage‐displayed epitope showed reactivity to sera from mice and patients with systemic \u003Cjats:italic>C. albicans\u003C\u002Fjats:italic> infection but not from those with oropharyngeal candidiasis and healthy individuals on Western blot. Furthermore, a new enzyme‐linked immunosorbent assay was developed to detect the anti‐Sap antibody with hybrid phage displaying Sap epitope VKYTS that can be recognised by anti‐Sap antibodies. Sequential sera were tested from patients and mice with systemic candidiasis and oropharyngeal candidiasis, and serum samples from healthy individuals were also included. The sensitivity and specificity were 77% and 88.3% for experimental mice, respectively. These values reached 60% and 85%, respectively, for human patients. These data indicate this phage‐displayed epitope as an effective and less expensive reagent would be a valuable probe for the detection of specific Sap antibody in the sera of patients and mice with systemic \u003Cjats:italic>C. albicans\u003C\u002Fjats:italic> infection.\u003C\u002Fjats:p>",{"EN":2465,"VI":2466},"Production of hybrid phage displaying secreted aspartyl proteinase epitope of \u003Ci>Candida albicans\u003C\u002Fi> and its application for the diagnosis of disseminated candidiasis","Sản xuất phage lai hiển thị epitop proteinase aspartyl được tiết ra của \u003Ci>Candida albicans\u003C\u002Fi> và ứng dụng của nó trong chẩn đoán căn bệnh nhiễm nấm toàn 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tắt\u003C\u002Fjats:title>\u003Cjats:p>Các tác nhân chống nấm triazole và imidazole ức chế quá trình chuyển hóa của vincristine, dẫn đến việc phơi nhiễm quá mức với các alkaloid vinca và các tác động độc thần kinh nghiêm trọng. Các báo cáo gần đây về những tương tác làm suy nhược giữa vincristine và itraconazole, cũng như posaconazole, voriconazole và ketoconazole nhấn mạnh sự cần thiết phải nâng cao nhận thức y học về sự kết hợp bất lợi này. Vì vậy, chúng tôi đã thực hiện một phân tích toàn diện các báo cáo về tương tác thuốc bất lợi (ADI) với sự kết hợp giữa vincristine và các tác nhân chống nấm azole, thiết lập một phân loại mới và cung cấp một tóm tắt chi tiết về các độc tính này. Trong số những bệnh nhân có đủ dữ liệu để phân tích, 47 cá nhân đã được xác định có ADI với sự kết hợp của vincristine và các azole chống nấm. Tuổi trung bình là 8 năm (1,3–68 năm), trong đó 33 (70%) có chẩn đoán bệnh bạch cầu lymphoblast cấp tính. Thời gian trung vị đến ADI với vincristine là 9,5 ngày với itraconazole, 13,5 ngày với posaconazole và 30 ngày với voriconazole. Số lượng vincristine được tiêm trước khi có ADI trung vị là 2 liều với itraconazole, 3 liều với posaconazole và 2 liều với voriconazole. Các ADI nghiêm trọng phổ biến nhất bao gồm độc tính đường tiêu hóa, bệnh thần kinh ngoại biên, hạ natri máu\u002FSIADH, bệnh thần kinh tự chủ và co giật. Sự hồi phục từ các ADI này xảy ra ở 80,6% bệnh nhân. Chúng tôi khuyến cáo sử dụng các tác nhân chống nấm thay thế nếu có thể ở những bệnh nhân nhận vincristine để tránh tương tác thuốc nghiêm trọng và có khả năng đe dọa tính mạng này.\u003C\u002Fjats:p>","\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Triazole and imidazole antifungal agents inhibit metabolism of vincristine, leading to excess vinca alkaloid exposure and severe neurotoxicity. Recent reports of debilitating interactions between vincristine and itraconazole, as well as posaconazole, voriconazole and ketoconazole underscore the need to improve medical awareness of this adverse combination. We, therefore, undertook a comprehensive analysis of reports of adverse drug interactions (ADIs) with the combination of vincristine and azole antifungal agents, established a new classification, and provided a detailed summary of these toxicities. In patients who had sufficient data for analysis, 47 individuals were identified who had an ADI with the combination of vincristine and antifungal azoles. Median age was 8 years (1.3–68 years) with 33(70%) having a diagnosis of acute lymphoblastic leukaemia. Median time to ADI with vincristine was 9.5 days with itraconazole, 13.5 days posaconazole and 30 days voriconazole. The median number of vincristine doses preceding the ADI was 2 doses with itraconazole, 3 doses posaconazole and 2 doses voriconazole. The most common severe ADIs included gastrointestinal toxicity, peripheral neuropathy, hyponatremia\u002FSIADH, autonomic neuropathy and seizures. Recovery from these ADIs occurred in 80.6% of patients. We recommend using alternative antifungal agents if possible in patients receiving vincristine to avoid this serious and potentially life‐threatening drug interaction.\u003C\u002Fjats:p>",{"EN":2727,"VI":2728},"Adverse interactions between antifungal azoles and vincristine: review and analysis of cases","Các tương tác bất lợi giữa azoles thuốc chống nấm và vincristine: đánh giá và phân tích các trường hợp",{"VOID":2730},"22126626",{"VOID":2732},"10.1111\u002Fj.1439-0507.2011.02158.x",[125],[380],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.2011.02158.x",[2737,2754,2769,2786,2803,2818,2833],{"id":2738,"sortIndex":24,"researcher":23,"roles":2739,"affiliations":2740,"properties":2749,"displayName":2751,"givenName":23,"familyName":23},"03aaf8a2-6151-4b5b-9db0-674b4b38d7b8",[],[2741],{"id":2742,"sortIndex":24,"affiliation":2743,"properties":23},"01a9d74d-91d7-4bf6-a0dd-d446eee0eebc",{"id":2742,"createTime":23,"updateTime":23,"relativeEntities":2744,"slug":23,"properties":2745,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":2748,"statistic":23},[],{"title":2746},{"EN":2747},"NIH Clinical Center Pharmacy Department, Bethesda, MD, USA.",[],{"title":2750,"openalex":2752},{"EN":2751},"Brad Moriyama",{"VOID":2753},"A5084097374",{"id":2755,"sortIndex":147,"researcher":23,"roles":2756,"affiliations":2757,"properties":2764,"displayName":2766,"givenName":23,"familyName":23},"2ff2d958-2378-4aba-96ab-b509a5b50ab0",[],[2758],{"id":2742,"sortIndex":24,"affiliation":2759,"properties":23},{"id":2742,"createTime":23,"updateTime":23,"relativeEntities":2760,"slug":23,"properties":2761,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":2763,"statistic":23},[],{"title":2762},{"EN":2747},[],{"title":2765,"openalex":2767},{"EN":2766},"Stacey A. 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tắt\u003C\u002Fjats:title>\u003Cjats:p>Bệnh nấm móng là bệnh móng thường gặp nhất và có thể khó chẩn đoán cũng như điều trị. Mục tiêu của nghiên cứu này là xác định tỷ lệ mắc bệnh, đặc điểm lâm sàng và vi nấm học của bệnh nấm móng ở miền Trung Tunisia. Đây là một nghiên cứu hồi cứu được thực hiện trong khoảng thời gian 22 năm (1986–2007). Nghiên cứu bao gồm 7151 bệnh nhân (4709 phụ nữ và 2442 nam giới) có triệu chứng nấm móng tay và\u002Fhoặc nấm móng chân. Các bệnh nhân đã được chuyển đến Phòng thí nghiệm Vi nấm - Ký sinh trùng của bệnh viện Farhat Hached ở Sousse để được khám vi nấm. Kỹ thuật vi phẫu trực tiếp và nuôi cấy vật liệu từ móng đã được thực hiện để chẩn đoán và xác định loài nấm gây bệnh. Bệnh nấm móng được xác nhận ở 78.6% bệnh nhân được khảo sát (5624\u002F7151). Tỷ lệ dương tính cao hơn ở phụ nữ so với nam giới. Cả ở nam và nữ, móng tay thường bị ảnh hưởng nhiều hơn so với móng chân. Không có mối liên hệ đáng kể nào được tìm thấy giữa giới tính và nấm móng chân, trong khi móng tay thường bị ảnh hưởng nhiều ở phụ nữ. Về các tác nhân gây bệnh, nấm dermatophyte, nấm men và nấm mốc chịu trách nhiệm cho 49.9%, 47.4% và 2.7% các trường hợp nấm móng tương ứng. Trong các trường hợp nhiễm nấm móng tay, nấm men là loại nấm phổ biến nhất (83.6%), trong đó \u003Cjats:italic>Candida albicans\u003C\u002Fjats:italic> là loài chủ yếu (51.6%). Ngược lại, trong nhiễm nấm móng chân, nấm dermatophyte phổ biến hơn (74.1%). \u003Cjats:italic>Trichophyton rubrum\u003C\u002Fjats:italic> là loài chiếm ưu thế nhất (88.1%). Nấm men thường thấy nhiều hơn ở phụ nữ trong khi nấm dermatophyte thì phổ biến hơn ở nam giới. Nấm mốc có liên quan trong 4.2% các trường hợp. Các loại nấm phổ biến nhất là \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> sp. và \u003Cjats:italic>Chrysosporium\u003C\u002Fjats:italic> sp. Bệnh nấm móng là một bệnh thường gặp ở miền Trung Tunisia. \u003Cjats:italic>T. rubrum\u003C\u002Fjats:italic> là tác nhân chiếm ưu thế trong nhiễm nấm móng chân và nấm men, chủ yếu là \u003Cjats:italic>C. albicans\u003C\u002Fjats:italic>, trong bệnh nấm móng tay.\u003C\u002Fjats:p>","\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Onychomycosis is the most frequently encountered nail disease and may be difficult to diagnose and treat. The objective of this study was to determine the prevalence, the clinical and mycological characteristics of onychomycosis in central Tunisia. It is a retrospective study performed over a 22‐year period (1986–2007). It included 7151 patients (4709 women and 2442 men) with suspected fingernails and\u002For toenails onychomycosis. The patients were referred to the Mycology‐Parasitology Laboratory of Farhat Hached hospital in Sousse for mycological examination. Both direct microscopy and culture of the nail material were performed to diagnose and identify the causative fungal species. Onychomycosis was confirmed in 78.6% of investigated patients (5624\u002F7151). The positivity rate was higher in women as compared with men. In both men and women, fingernails were most frequently involved than toenails. No significant relation was found between gender and toenails onychomycosis, whereas fingernails were frequently involved in women. As far as aetiological agents are considered, dermatophytes, yeast and moulds were responsible for 49.9%, 47.4% and 2.7% of onyxis cases respectively. In fingernail infections, yeast were the most frequent fungi (83.6%), \u003Cjats:italic>Candida albicans\u003C\u002Fjats:italic> being the leading species (51.6%). In contrast, in toenail infections, dermatophytes were more frequent (74.1%). \u003Cjats:italic>Trichophyton rubrum\u003C\u002Fjats:italic> was by far the dominant species (88.1%). Yeast were observed more frequently in women whereas dermatophytes were more common in men. Moulds were involved in 4.2% of cases. The most frequent species were \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> sp. and \u003Cjats:italic>Chrysosporium\u003C\u002Fjats:italic> sp. Onychomycosis is a frequent disease in central Tunisia. \u003Cjats:italic>T. rubrum\u003C\u002Fjats:italic> is the predominant agent in toenails infection and yeast, mainly \u003Cjats:italic>C. albicans\u003C\u002Fjats:italic>, in fingernails onychomycosis.\u003C\u002Fjats:p>",{"EN":3050,"VI":3051},"Clinical and mycological features of onychomycosis in central Tunisia: a 22 years retrospective study (1986–2007)","Đặc điểm lâm sàng và vi nấm học của bệnh nấm móng ở miền Trung Tunisia: Nghiên cứu hồi cứu 22 năm (1986–2007)",{"VOID":3053},"23094998",{"VOID":3055},"10.1111\u002Fmyc.12016","2025-01-06T09:10:05.142+00:00",[125],[380],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fmyc.12016",[3061,3078,3095,3110,3127,3144],{"id":3062,"sortIndex":24,"researcher":23,"roles":3063,"affiliations":3064,"properties":3073,"displayName":3075,"givenName":23,"familyName":23},"e8d5eea5-c7b8-4cde-aba5-2b8d7ac76b1a",[],[3065],{"id":3066,"sortIndex":24,"affiliation":3067,"properties":23},"a96a855b-208b-4953-8517-bc4d59d9cd05",{"id":3066,"createTime":23,"updateTime":23,"relativeEntities":3068,"slug":23,"properties":3069,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":3072,"statistic":23},[],{"title":3070},{"EN":3071},"Parasitology-Mycology Laboratory, Farhat Hached Hospital, Sousse, Tunisie",[],{"title":3074,"openalex":3076},{"EN":3075},"Imen Dhib",{"VOID":3077},"A5022009680",{"id":3079,"sortIndex":147,"researcher":23,"roles":3080,"affiliations":3081,"properties":3088,"displayName":3092,"givenName":23,"familyName":23},"fddea28f-c304-4640-9c16-892e6eb48430",[],[3082],{"id":3066,"sortIndex":24,"affiliation":3083,"properties":23},{"id":3066,"createTime":23,"updateTime":23,"relativeEntities":3084,"slug":23,"properties":3085,"entityType":23,"verifyStatus":23,"verifyTime":23,"verifyNote":23,"languages":23,"translateLanguages":23,"viewCount":23,"url":23,"parentIds":3087,"statistic":23},[],{"title":3086},{"EN":3071},[],{"orcid":3089,"title":3091,"openalex":3093},{"VOID":3090},"https:\u002F\u002Forcid.org\u002F0000-0002-4613-6689",{"EN":3092},"A. 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A Mexican survey, Europ J Dermatol, 20, 611",{},{"id":23,"text":3232,"url":23,"identifiers":3233},"10.1111\u002Fj.1346-8138.2007.00262.x",{"doi":3232},{"id":23,"text":3235,"url":23,"identifiers":3236},"10.1111\u002Fj.1439-0507.2008.01651.x",{"doi":3235},{"id":23,"text":3238,"url":23,"identifiers":3239},"10.1007\u002Fs11046-008-9100-9",{"doi":3238},{"id":23,"text":3241,"url":23,"identifiers":3242},"10.1111\u002Fj.1365-4632.2009.04126.x",{"doi":3241},{"id":23,"text":3244,"url":23,"identifiers":3245},"Makni F, 1998, Les onychomycoses à Sfax (Tunisie), J Mycol Méd, 8, 108",{},{"id":23,"text":3247,"url":23,"identifiers":3248},"10.1111\u002Fj.1440-0960.2010.00678.x",{"doi":3247},{"id":23,"text":3250,"url":23,"identifiers":3251},"10.1016\u002FS1130-1406(07)70024-4",{"doi":3250},{"id":23,"text":3253,"url":23,"identifiers":3254},"Bouratbine A, 1997, Topographie et Etiologie des Mycoses Superficielles dans une population non hospitalière de la région de Tunis (Tunisie), J Mycol Méd, 7, 199",{},{"id":23,"text":3256,"url":23,"identifiers":3257},"10.1007\u002Fs11046-009-9209-5",{"doi":3256},{"id":23,"text":3259,"url":23,"identifiers":3260},"Miklic P, 2010, The frequency of superficial mycoses according to agents isolated during a ten‐year period (1999–2008) in Zagreb area, Croatia, Acta Dermatovenerol Croat, 18, 92",{},{"id":23,"text":3262,"url":23,"identifiers":3263},"10.3314\u002Fjjmm.51.23",{"doi":3262},{"id":23,"text":3265,"url":23,"identifiers":3266},"10.1111\u002Fj.1365-4632.2008.03563.x",{"doi":3265},{"id":23,"text":3268,"url":23,"identifiers":3269},"10.1111\u002Fj.1439-0507.2004.01066.x",{"doi":3268},{"id":23,"text":3271,"url":23,"identifiers":3272},"10.1007\u002Fs11046-009-9210-z",{"doi":3271},{"id":23,"text":3274,"url":23,"identifiers":3275},"10.4103\u002F0255-0857.40522",{"doi":3274},{"id":23,"text":3277,"url":23,"identifiers":3278},"Guibal F, Epidémiologie et prise en charge des onychomycoses pratique dermatologique libérale en France, Ann Dermatol Vener, 135, 561, 10.1016\u002Fj.annder.2008.05.004",{"doi":3279},"10.1016\u002Fj.annder.2008.05.004",{"id":23,"text":3281,"url":23,"identifiers":3282},"Simonnet C, 2011, Epidemiology of superficial fungal diseases in French Guiana: a three‐year retrospective analysis, Med Mycol, 49, 608",{},{"id":23,"text":3284,"url":23,"identifiers":3285},"10.1016\u002Fj.mycmed.2010.03.004",{"doi":3284},{"id":23,"text":3287,"url":23,"identifiers":3288},"Adefemi SA, 2010, Superficial fungal infections seen at a tertiary health centre: clinical and mycological studies, West Afr J Med, 29, 267",{},{"id":23,"text":3290,"url":23,"identifiers":3291},"Boukachabine K, 2005, Onychomycosis in Morocco: experience of the parasitology and medical mycology laboratory from Rabat children hospital (1982–2003), Ann Biol Clin, 63, 639",{},{"id":23,"text":3293,"url":23,"identifiers":3294},"10.1111\u002Fj.1439-0507.2006.01230.x",{"doi":3293},{"id":23,"text":3296,"url":23,"identifiers":3297},"10.1016\u002Fj.mycmed.2011.04.002",{"doi":3296},{"id":23,"text":3299,"url":23,"identifiers":3300},"10.1128\u002FCMR.11.3.415",{"doi":3299},{"id":23,"text":3302,"url":23,"identifiers":3303},"10.1007\u002Fs11046-010-9360-z",{"doi":3302},{"id":23,"text":3305,"url":23,"identifiers":3306},"10.1016\u002Fj.mycmed.2006.11.001",{"doi":3305},{"id":23,"text":3308,"url":23,"identifiers":3309},"Hammadi K, 2007, Dermatophytes in North West of algeria a prospective study, Middle-East J Sci Res, 2, 104",{},{"id":23,"text":3311,"url":23,"identifiers":3312},"Pau M, 2010, Epidemiology of Tinea pedis in Cagliari, Italy, Giorn Ita Dermatol Vener, 145, 1",{}]