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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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This property determines to a large extent the pharmacokinetics of itraconazole and differentiates it from the hydrophilic triazole antifungal fluconazole.\u003C\u002Fjats:p>\u003Cjats:p>The pharmacokinetics of itraconazole in man are characterized by a good oral absorption, an extensive tissue distribution with tissue concentrations many times higher than in plasma, a relatively long elimination half‐life of about one day and a biotransformation into a large number of metabolites. One of them, hydroxy‐itraconazole, is antifungally active and explains why antifungal plasma levels, when measured by bioassay, are about three times the itraconazole levels measured by a specific HPLC‐method.\u003C\u002Fjats:p>\u003Cjats:p>Distribution studies have shown that therapeutically active levels of itraconazole are maintained much longer in some infected tissues than in plasma. For instance, active levels persist for four days in the vaginal epithelium after a one‐day treatment and for 3 weeks in the stratum cor‐neum of the skin after treatment has been stopped. Unlike fluconazole, itraconazole does not interfere with mammalian drug metabolizing enzymes, minimizing the risk of interaction with concomitantly administered drugs. These pharmacokinetic properties may contribute to the high eficacy and safety of itraconazole in patients with various mycotic infections. New pharmaceutical formulations are being explored in order to broaden the application field of itraconazole to intravenous and oral therapy of patients with malabsorption.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>Tóm tắt: \u003C\u002Fjats:bold> Itraconazole (R 51211) là nguyên mẫu của một nhóm thuốc chống nấm triazole có tính chất ưa mỡ cao. Tính chất này quyết định phần lớn dược động học của itraconazole và làm nó khác biệt so với thuốc chống nấm triazole ưa nước fluconazole.\u003C\u002Fjats:p>\u003Cjats:p>Dược động học của itraconazole ở người được đặc trưng bởi sự hấp thu qua đường uống tốt, phân bố rộng khắp trong mô với nồng độ mô cao gấp nhiều lần trong huyết tương, thời gian bán hủy bài tiết tương đối dài khoảng một ngày và sự chuyển hóa thành một số lượng lớn các chất chuyển hóa. Một trong số đó, hydroxy-itraconazole, có hoạt động chống nấm và giải thích tại sao mức nồng độ chống nấm trong huyết tương, khi đo bằng phương pháp sinh học, cao gấp khoảng ba lần so với mức nồng độ itraconazole đo bằng phương pháp HPLC đặc hiệu.\u003C\u002Fjats:p>\u003Cjats:p>Các nghiên cứu phân bố đã chỉ ra rằng các mức độ hoạt động điều trị của itraconazole được duy trì lâu hơn nhiều trong một số mô nhiễm bệnh so với trong huyết tương. Ví dụ, mức độ hoạt động tồn tại trong bốn ngày ở biểu mô âm đạo sau khi điều trị một ngày và trong ba tuần ở lớp bì của da sau khi ngừng điều trị. Khác với fluconazole, itraconazole không can thiệp vào các enzym chuyển hóa thuốc ở động vật có vú, giảm thiểu nguy cơ tương tác với các thuốc được dùng đồng thời. Những tính chất dược động học này có thể góp phần vào hiệu quả và an toàn cao của itraconazole đối với bệnh nhân mắc các nhiễm trùng do nấm khác nhau. Các dạng bào chế mới đang được khám phá để mở rộng phạm vi ứng dụng của itraconazole cho liệu pháp tiêm tĩnh mạch và đường uống ở bệnh nhân mắc chứng kém hấp thu.\u003C\u002Fjats:p>",{"EN":972,"VI":973},"The Clinical Pharmacokinetics of Itraconazole: An Overview","Dược động học lâm sàng của Itraconazole: Tổng quan",{"VOID":975},"2561187",{"VOID":977},"10.1111\u002Fj.1439-0507.1989.tb02296.x","PUBLICATION","Auto Verify",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.1989.tb02296.x",[984,1001,1016,1031,1048,1063,1078,1093,1110],{"id":985,"sortIndex":32,"researcher":28,"roles":986,"affiliations":987,"properties":996,"displayName":998,"givenName":28,"familyName":28},"827a6f44-acb3-4936-846e-5e528078cf09",[],[988],{"id":989,"sortIndex":32,"affiliation":990,"properties":28},"bffc0858-e2b3-4784-b1b1-8c5382cde22b",{"id":989,"createTime":28,"updateTime":28,"relativeEntities":991,"slug":28,"properties":992,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":995,"statistic":28},[],{"title":993},{"EN":994},"Departments of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Beerse, Belgium",[],{"title":997,"openalex":999},{"EN":998},"Jos Heykants",{"VOID":1000},"A5064352837",{"id":1002,"sortIndex":40,"researcher":28,"roles":1003,"affiliations":1004,"properties":1011,"displayName":1013,"givenName":28,"familyName":28},"96d40b66-3637-4876-9a3d-eaf0ce15102c",[],[1005],{"id":989,"sortIndex":32,"affiliation":1006,"properties":28},{"id":989,"createTime":28,"updateTime":28,"relativeEntities":1007,"slug":28,"properties":1008,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1010,"statistic":28},[],{"title":1009},{"EN":994},[],{"title":1012,"openalex":1014},{"EN":1013},"Achiel Van Peer",{"VOID":1015},"A5008196740",{"id":1017,"sortIndex":123,"researcher":28,"roles":1018,"affiliations":1019,"properties":1026,"displayName":1028,"givenName":28,"familyName":28},"2edfc5fd-d80d-4b80-8218-22524dad1047",[],[1020],{"id":989,"sortIndex":32,"affiliation":1021,"properties":28},{"id":989,"createTime":28,"updateTime":28,"relativeEntities":1022,"slug":28,"properties":1023,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1025,"statistic":28},[],{"title":1024},{"EN":994},[],{"title":1027,"openalex":1029},{"EN":1028},"Vera Van de Velde",{"VOID":1030},"A5016292547",{"id":1032,"sortIndex":42,"researcher":28,"roles":1033,"affiliations":1034,"properties":1043,"displayName":1045,"givenName":28,"familyName":28},"03652ce2-998d-4f7e-8eb4-9dffd07ac00e",[],[1035],{"id":1036,"sortIndex":32,"affiliation":1037,"properties":28},"6c32bf4a-c8f3-48e3-8630-1ac2461e2dfe",{"id":1036,"createTime":28,"updateTime":28,"relativeEntities":1038,"slug":28,"properties":1039,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1042,"statistic":28},[],{"title":1040},{"EN":1041},"Departments of Clinical Pharmacology, Janssen Research Foundation, Beerse, Belgium",[],{"title":1044,"openalex":1046},{"EN":1045},"P. 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E.Chwetzoff P.Stéphan D.Gluck‐man(1986):Etude des concentrations plas‐matiques de l'itraconazole en traitement prophy‐lactique des greffes de moelle pendant 5 semaines. Clinical Research Report R 51211 Laboratoires Janssen France.",{},{"id":28,"text":1276,"url":28,"identifiers":1277},"Levron J.C. P.Stéphan&G.Sanz(1985):Essai d'intéraction entre l'itraconazole et un anticoagu‐lantl antivitamine KI (acénocoumarol). Preclini‐cal Research Report R 51211 Laboratoires Janssen France.",{},{"id":28,"text":1279,"url":28,"identifiers":1280},"Meuldermans W. J.Hendrickx A.VanPeer E.Mostmans M.Bockx D.Roelant R.Woesten‐borghs R.Gasparini W.Lauwers J.VanCutsem&J.Heykants(1986):Absportion excretion and metabolism of itraconazole in volunteers after a single oral dose. 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Clinical Research Report R. 51211 Janssen U.K.",{},{"id":28,"text":1333,"url":28,"identifiers":1334},"10.1016\u002F0378-4347(87)80249-9",{"doi":1333},false,{"id":1337,"createTime":1338,"updateTime":1339,"relativeEntities":1340,"slug":1341,"properties":1342,"entityType":978,"verifyStatus":883,"verifyTime":1338,"verifyNote":1359,"languages":1360,"translateLanguages":1361,"viewCount":32,"primaryUrl":1362,"fullTextUrl":28,"authors":1363,"publicationType":1127,"publisherRelationship":1401,"citationCount":1455,"citationInfo":1456,"publishDate":1459,"publishYear":1457,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":1460,"openAccess":28,"references":1461,"isForceReanalyzing":1335},"c6596fdc-4428-4e05-ab80-32d86bf92a99","2024-09-11T10:59:33.565+00:00","2025-02-23T01:41:17.607+00:00",[],"-i-Aspergillus-flavus-i-an-emerging-non-i-fumigatus-Aspergillus-i-species-of-significance",{"mag":1343,"keywords":1345,"openalex":1347,"abstract":1349,"title":1352,"pm":1355,"doi":1357},{"VOID":1344},"2069723009",{"VI":1346},"Aspergillus flavus, aspergillosis xâm lấn, vi sinh vật học, độc tính, dịch tễ học",{"VOID":1348},"W2069723009",{"EN":1350,"VI":1351},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Invasive aspergillosis is rare in immunocompetent people but contributes to significant morbidity and mortality in immunosuppressed patients. The majority (approximately 80%) of invasive Aspergillus infections is caused by \u003Cjats:italic>Aspergillus fumigatus\u003C\u002Fjats:italic>. The second most frequent (approximately 15–20%) pathogenic species is \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> and to a lesser extent, \u003Cjats:italic>Aspergillus niger\u003C\u002Fjats:italic> and \u003Cjats:italic>Aspergillus terreus\u003C\u002Fjats:italic>. \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> has emerged as a predominant pathogen in patients with fungal sinusitis and fungal keratitis in several institutions worldwide. To date, there has not been any publication exclusively reviewing the topic of \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> in the literature. This article reviews the microbiology, toxigenicity and epidemiology of \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> as well as describes the clinical characteristics, diagnosis and management of infections caused by this organism.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Bệnh aspergillosis xâm lấn rất hiếm gặp ở những người có hệ miễn dịch bình thường nhưng góp phần gây ra tỷ lệ bệnh tật và tử vong đáng kể ở những bệnh nhân suy giảm miễn dịch. Phần lớn (khoảng 80%) các ca nhiễm nấm \u003Ci>Aspergillus\u003C\u002Fi> xâm lấn là do \u003Cjats:italic>Aspergillus fumigatus\u003C\u002Fjats:italic> gây ra. Loài gây bệnh phổ biến thứ hai (khoảng 15-20%) là \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic>, và một phần nhỏ hơn là \u003Cjats:italic>Aspergillus niger\u003C\u002Fjats:italic> và \u003Cjats:italic>Aspergillus terreus\u003C\u002Fjats:italic>. \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> đã xuất hiện như một tác nhân chủ yếu ở những bệnh nhân bị viêm xoang nấm và viêm giác mạc nấm tại một số cơ sở y tế trên toàn thế giới. Đến nay, chưa có công bố nào độc quyền xem xét chủ đề về \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> trong tài liệu. Bài báo này xem xét về vi sinh vật học, độc tính và dịch tễ học của \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> cũng như mô tả các đặc điểm lâm sàng, chẩn đoán và quản lý các nhiễm trùng do loại sinh vật này gây ra.\u003C\u002Fjats:p>",{"EN":1353,"VI":1354},"\u003Ci>Aspergillus flavus\u003C\u002Fi>: an emerging non‐\u003Ci>fumigatus Aspergillus\u003C\u002Fi> species of significance","\u003Ci>Aspergillus flavus\u003C\u002Fi>: một loài \u003Ci>Aspergillus\u003C\u002Fi> không phải \u003Ci>fumigatus\u003C\u002Fi> đang nổi lên với tầm quan trọng",{"VOID":1356},"19207851",{"VOID":1358},"10.1111\u002Fj.1439-0507.2008.01642.x","Author affiliation is blank",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.2008.01642.x",[1364,1381,1390],{"id":1365,"sortIndex":32,"researcher":28,"roles":1366,"affiliations":1367,"properties":1376,"displayName":1378,"givenName":28,"familyName":28},"87b57a07-81de-469d-9868-5dc00e91b978",[],[1368],{"id":1369,"sortIndex":32,"affiliation":1370,"properties":28},"dea9c52a-2854-4ebe-a4a7-60b4d050e55b",{"id":1369,"createTime":28,"updateTime":28,"relativeEntities":1371,"slug":28,"properties":1372,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1375,"statistic":28},[],{"title":1373},{"EN":1374},"Division of Infectious Diseases, Wayne State University, John D. 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647",{},{"id":28,"text":1824,"url":28,"identifiers":1825},"10.1086\u002F317452",{"doi":1824},{"id":28,"text":1827,"url":28,"identifiers":1828},"10.1378\u002Fchest.114.1.251",{"doi":1827},{"id":28,"text":1830,"url":28,"identifiers":1831},"10.1378\u002Fchest.114.1.131",{"doi":1830},{"id":28,"text":1833,"url":28,"identifiers":1834},"10.1016\u002F0002-9343(93)90258-Q",{"doi":1833},{"id":28,"text":1836,"url":28,"identifiers":1837},"10.1093\u002Finfdis\u002F167.4.905",{"doi":1836},{"id":28,"text":1839,"url":28,"identifiers":1840},"10.1093\u002Fclinids\u002F17.3.344",{"doi":1839},{"id":28,"text":1842,"url":28,"identifiers":1843},"Wrzolek MA, 1995, Opportunistic infections of the central nervous system in children with HIV infection: report of 9 autopsy cases and review of literature, Clin Neuropathol, 14, 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BT, 1990, Aspergillar osteomyelitis of the acetabulum. A case report and review of the literature, Orthop Rev, 19, 58",{},{"id":28,"text":1917,"url":28,"identifiers":1918},"Olle JE, 1990, Aspergillus osteomyelitis of the sternum description of a case and review of the literature, Enferm Infecc Microbiol Clin, 8, 94",{},{"id":28,"text":1920,"url":28,"identifiers":1921},"10.1007\u002FBF01704898",{"doi":1920},{"id":28,"text":1923,"url":28,"identifiers":1924},"Chi CY, 2003, Aspergillus flavus epidural abscess and osteomyelitis in a diabetic patient, J Microbiol Immunol Infect, 36, 145",{},{"id":28,"text":1926,"url":28,"identifiers":1927},"Cortet B, 1994, Aspergillus spondylodiscitis: successful conservative treatment in 9 cases, J Rheumatol, 21, 1287",{},{"id":28,"text":1929,"url":28,"identifiers":1930},"10.1086\u002F342699",{"doi":1929},{"id":28,"text":1932,"url":28,"identifiers":1933},"10.1309\u002FEXBVYAUPENBM285Y",{"doi":1932},{"id":28,"text":1935,"url":28,"identifiers":1936},"10.1001\u002Farchinte.144.7.1462",{"doi":1935},{"id":28,"text":1938,"url":28,"identifiers":1939},"10.1136\u002Fjcp.49.10.798",{"doi":1938},{"id":28,"text":1941,"url":28,"identifiers":1942},"Chumpitazi BF, 2000, Aspergillus fumigatus antigen detection in sera from patients at risk for invasive aspergillosis, J Clin Microbiol, 38, 438, 10.1128\u002FJCM.38.1.438-443.2000",{"doi":1943},"10.1128\u002FJCM.38.1.438-443.2000",{"id":28,"text":1945,"url":28,"identifiers":1946},"10.1128\u002FJCM.35.9.2206-2209.1997",{"doi":1945},{"id":28,"text":1948,"url":28,"identifiers":1949},"10.1128\u002FJCM.40.11.4382-4387.2002",{"doi":1948},{"id":28,"text":1951,"url":28,"identifiers":1952},"10.1053\u002Fjinf.2001.0883",{"doi":1951},{"id":28,"text":1954,"url":28,"identifiers":1955},"10.1128\u002FJCM.40.6.2224-2227.2002",{"doi":1954},{"id":28,"text":1957,"url":28,"identifiers":1958},"10.1007\u002Fs11046-005-4996-9",{"doi":1957},{"id":28,"text":1960,"url":28,"identifiers":1961},"10.1128\u002FJCM.43.1.299-305.2005",{"doi":1960},{"id":28,"text":1963,"url":28,"identifiers":1964},"10.1128\u002FJCM.38.4.1510-1515.2000",{"doi":1963},{"id":28,"text":1966,"url":28,"identifiers":1967},"10.1097\u002F00019606-199710000-00002",{"doi":1966},{"id":28,"text":1969,"url":28,"identifiers":1970},"10.1128\u002FJCM.38.11.4186-4192.2000",{"doi":1969},{"id":28,"text":1972,"url":28,"identifiers":1973},"10.1128\u002FJCM.42.8.3495-3504.2004",{"doi":1972},{"id":28,"text":1975,"url":28,"identifiers":1976},"Martin 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10.1128\u002FJCM.38.10.3612-3618.2000",{"doi":1981},"10.1128\u002FJCM.38.10.3612-3618.2000",{"id":28,"text":1983,"url":28,"identifiers":1984},"10.1099\u002Fjmm.0.45856-0",{"doi":1983},{"id":28,"text":1972,"url":28,"identifiers":1986},{"doi":1972},{"id":28,"text":1988,"url":28,"identifiers":1989},"10.1080\u002F13693780310001656786",{"doi":1988},{"id":28,"text":1991,"url":28,"identifiers":1992},"10.1093\u002Fjac\u002F42.6.741",{"doi":1991},{"id":28,"text":1994,"url":28,"identifiers":1995},"10.1016\u002F0002-9343(89)90475-0",{"doi":1994},{"id":28,"text":1997,"url":28,"identifiers":1998},"10.1067\u002Fmjd.2002.120627",{"doi":1997},{"id":28,"text":2000,"url":28,"identifiers":2001},"10.1093\u002Fjac\u002Fdkg434",{"doi":2000},{"id":28,"text":2003,"url":28,"identifiers":2004},"10.1128\u002FAAC.44.8.2017-2022.2000",{"doi":2003},{"id":28,"text":2006,"url":28,"identifiers":2007},"10.1128\u002FAAC.48.10.3690-3696.2004",{"doi":2006},{"id":28,"text":2009,"url":28,"identifiers":2010},"10.1016\u002Fj.drup.2006.01.001",{"doi":2009},{"id":28,"text":2012,"url":28,"identifiers":2013},"10.1053\u002Fjinf.2000.0747",{"doi":2012},{"id":28,"text":2015,"url":28,"identifiers":2016},"Varanasi NL, 2001, In Vitro Susceptibility and Azole Resistance Among Clinical and Laboratory‐Selected Isolates of Aspergillus Flavus Obtained From Three Continents",{},{"id":28,"text":2018,"url":28,"identifiers":2019},"10.1128\u002FAAC.49.2.512-517.2005",{"doi":2018},{"id":28,"text":2000,"url":28,"identifiers":2021},{"doi":2000},{"id":28,"text":1997,"url":28,"identifiers":2023},{"doi":1997},{"id":28,"text":2025,"url":28,"identifiers":2026},"10.1016\u002FS0732-8893(98)00102-3",{"doi":2025},{"id":28,"text":2028,"url":28,"identifiers":2029},"10.1093\u002Fjac\u002F46.2.229",{"doi":2028},{"id":28,"text":2031,"url":28,"identifiers":2032},"10.1111\u002Fj.1348-0421.1999.tb01231.x",{"doi":2031},{"id":28,"text":2034,"url":28,"identifiers":2035},"Rose HD, 1979, Filtering hospital air decreases Aspergillus spore counts, Am Rev Respir Dis, 119, 511",{},{"id":28,"text":2037,"url":28,"identifiers":2038},"Sarubbi FA, 1982, Increased recovery of Aspergillus flavus from respiratory specimens during hospital construction, Am Rev Respir Dis, 125, 33",{},{"id":28,"text":2040,"url":28,"identifiers":2041},"10.1086\u002F502101",{"doi":2040},{"id":28,"text":2043,"url":28,"identifiers":2044},"10.1016\u002Fj.jhin.2006.02.014",{"doi":2043},{"id":28,"text":2046,"url":28,"identifiers":2047},"10.1128\u002FJCM.38.6.2419-2422.2000",{"doi":2046},{"id":28,"text":1981,"url":28,"identifiers":2049},{"doi":1981},{"id":28,"text":2051,"url":28,"identifiers":2052},"10.1128\u002Fjcm.34.2.345-351.1996",{"doi":2051},{"id":28,"text":2054,"url":28,"identifiers":2055},"10.1007\u002Fs10295-005-0226-1",{"doi":2054},{"id":28,"text":2057,"url":28,"identifiers":2058},"10.1093\u002Fclinids\u002F21.1.210",{"doi":2057},{"id":28,"text":2060,"url":28,"identifiers":2061},"10.3109\u002F02688699409002390",{"doi":2060},{"id":28,"text":2063,"url":28,"identifiers":2064},"10.1136\u002Fjnnp.56.2.188",{"doi":2063},{"id":28,"text":2066,"url":28,"identifiers":2067},"10.1053\u002Fjinf.2000.0786",{"doi":2066},{"id":28,"text":2069,"url":28,"identifiers":2070},"10.1128\u002FJCM.42.2.665-669.2004",{"doi":2069},{"id":28,"text":2072,"url":28,"identifiers":2073},"10.3314\u002Fjjmm.39.167",{"doi":2072},{"id":28,"text":2075,"url":28,"identifiers":2076},"10.1111\u002Fj.1439-0507.2004.00980.x",{"doi":2075},{"id":28,"text":2078,"url":28,"identifiers":2079},"10.1053\u002Fjinf.2000.0637",{"doi":2078},{"id":28,"text":2081,"url":28,"identifiers":2082},"Demaria RG, 2000, Aspergillus flavus mitral valve endocarditis after lung abscess, J Heart Valve Dis, 9, 786",{},{"id":28,"text":2084,"url":28,"identifiers":2085},"10.1067\u002Fmjd.2001.107776",{"doi":2084},{"id":28,"text":2087,"url":28,"identifiers":2088},"10.1055\u002Fs-2007-1013214",{"doi":2087},{"id":28,"text":2090,"url":28,"identifiers":2091},"10.1093\u002Fclinids\u002F20.4.1052",{"doi":2090},{"id":28,"text":2093,"url":28,"identifiers":2094},"Drakos PE, 1993, Invasive fungal sinusitis in patients undergoing bone marrow transplantation, Bone Marrow Transplant, 12, 203",{},{"id":28,"text":2096,"url":28,"identifiers":2097},"10.3109\u002F08880019309016552",{"doi":2096},{"id":28,"text":2099,"url":28,"identifiers":2100},"10.1016\u002FS0190-9622(08)81879-8",{"doi":2099},{"id":28,"text":2102,"url":28,"identifiers":2103},"10.1078\u002F1438-4221-00196",{"doi":2102},{"id":28,"text":2105,"url":28,"identifiers":2106},"10.1099\u002Fjmm.0.05421-0",{"doi":2105},{"id":28,"text":2108,"url":28,"identifiers":2109},"10.1016\u002FS1087-1845(02)00526-1",{"doi":2108},{"id":2111,"createTime":2112,"updateTime":2113,"relativeEntities":2114,"slug":2115,"properties":2116,"entityType":978,"verifyStatus":26,"verifyTime":2112,"verifyNote":979,"languages":2133,"translateLanguages":2134,"viewCount":32,"primaryUrl":2135,"fullTextUrl":28,"authors":2136,"publicationType":1127,"publisherRelationship":2233,"citationCount":570,"citationInfo":2285,"publishDate":1186,"publishYear":1184,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":2287,"openAccess":28,"references":2288,"isForceReanalyzing":1335},"f0c22510-aae2-4fbe-be8f-8b92d0d6a93a","2024-10-02T06:33:17.848+00:00","2025-02-23T01:42:14.622+00:00",[],"Antifungal-Prophylaxis-with-Itraconazole-in-Prolonged-Neutropenia-Correlation-with-Plasma-Levels",{"mag":2117,"keywords":2119,"openalex":2121,"abstract":2123,"title":2126,"pm":2129,"doi":2131},{"VOID":2118},"2020985135",{"VI":2120},"itraconazole, dự phòng nấm, nhiễm trùng nấm, giảm bạch cầu, bệnh lý huyết học",{"VOID":2122},"W2020985135",{"EN":2124,"VI":2125},"\u003Cjats:p>\u003Cjats:bold>Summary: \u003C\u002Fjats:bold> Seventy‐two patients with haematological malignancies were treated prophylactically with itraconazole during remission induction therapy.\u003C\u002Fjats:p>\u003Cjats:p>The incidence of proven fungal infections was 18 %, of which 12.5 % were fatal. \u003Cjats:italic>Aspergillus, Tomlopsis\u003C\u002Fjats:italic> and \u003Cjats:italic>Candida\u003C\u002Fjats:italic> proved to be major invasive pathogens. Plasma levels of itraconazole were monitored for all patients.\u003C\u002Fjats:p>\u003Cjats:p>The occurrence of fungal infection is significantly greater in the group where no therapeutic plasma levels were obtained during at least two weeks.\u003C\u002Fjats:p>\u003Cjats:p>There is a clear need to obtain quick information on itraconazole plasma levels in order to adapt dosage during prophylactic treatment in immunocompromised patients.\u003C\u002Fjats:p>\u003Cjats:p>The influence of itraconazole on liver function tests could not be separated from concomitant cytostatic or antibiotic treatment. No jaundice directly related to itraconazole could be found.\u003C\u002Fjats:p>\u003Cjats:p>During itraconazole prophylaxis a shift from classic pathogens such as \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> and \u003Cjats:italic>Candida, to Fusarium, Torulopsis\u003C\u002Fjats:italic> and \u003Cjats:italic>Mucor\u003C\u002Fjats:italic>, may be seen.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>Tóm tắt: \u003C\u002Fjats:bold> Bảy mươi hai bệnh nhân mắc các bệnh lý huyết học đã được điều trị dự phòng bằng itraconazole trong quá trình điều trị khởi phát khả năng hồi phục.\u003C\u002Fjats:p>\u003Cjats:p>Tỷ lệ xảy ra nhiễm trùng nấm đã được xác định là 18%, trong đó 12.5% là tử vong. \u003Cjats:italic>Aspergillus, Tomlopsis\u003C\u002Fjats:italic> và \u003Cjats:italic>Candida\u003C\u002Fjats:italic> đã được chứng minh là các tác nhân xâm lấn chính. Nồng độ itraconazole trong huyết thanh đã được theo dõi ở tất cả bệnh nhân.\u003C\u002Fjats:p>\u003Cjats:p>Sự xuất hiện của nhiễm trùng nấm cao hơn đáng kể ở nhóm không đạt được nồng độ huyết thanh điều trị trong ít nhất hai tuần.\u003C\u002Fjats:p>\u003Cjats:p>Có một nhu cầu rõ ràng về việc nhanh chóng thu thập thông tin về nồng độ itraconazole trong huyết thanh để điều chỉnh liều lượng trong điều trị dự phòng cho các bệnh nhân suy giảm miễn dịch.\u003C\u002Fjats:p>\u003Cjats:p>Ảnh hưởng của itraconazole đến các xét nghiệm chức năng gan không thể tách rời khỏi việc điều trị đồng thời bằng hóa trị liệu hoặc kháng sinh. Không có dấu hiệu vàng da nào được tìm thấy mà có liên quan trực tiếp đến itraconazole.\u003C\u002Fjats:p>\u003Cjats:p>Trong suốt giai đoạn dự phòng bằng itraconazole, có thể thấy sự chuyển dịch từ các tác nhân gây bệnh cổ điển như \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> và \u003Cjats:italic>Candida\u003C\u002Fjats:italic> sang \u003Cjats:italic>Fusarium, Torulopsis\u003C\u002Fjats:italic> và \u003Cjats:italic>Mucor\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>",{"EN":2127,"VI":2128},"Antifungal Prophylaxis with Itraconazole in Prolonged Neutropenia: Correlation with Plasma Levels","Dự Phòng Nấm Dựa Trên Itraconazole Trong Tình Trạng Giảm Bạch Cầu Kéo Dài: Mối Liên Hệ Với Nồng Độ Trong Huyết Thanh",{"VOID":2130},"2561181",{"VOID":2132},"10.1111\u002Fj.1439-0507.1989.tb02299.x",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.1989.tb02299.x",[2137,2154,2169,2186,2201,2216],{"id":2138,"sortIndex":32,"researcher":28,"roles":2139,"affiliations":2140,"properties":2149,"displayName":2151,"givenName":28,"familyName":28},"c8716c6c-d5ca-4230-ba61-8392a71d51cb",[],[2141],{"id":2142,"sortIndex":32,"affiliation":2143,"properties":28},"37cedfd4-15ba-42b0-8e14-7b8e82c32a80",{"id":2142,"createTime":28,"updateTime":28,"relativeEntities":2144,"slug":28,"properties":2145,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2148,"statistic":28},[],{"title":2146},{"EN":2147},"University Hospital, Hematology, Microbiology, Leuven, Belgium",[],{"title":2150,"openalex":2152},{"EN":2151},"Marc Boogaerts",{"VOID":2153},"A5062839406",{"id":2155,"sortIndex":40,"researcher":28,"roles":2156,"affiliations":2157,"properties":2164,"displayName":2166,"givenName":28,"familyName":28},"cb20e4bf-6ea6-492c-a5da-eecf71adc428",[],[2158],{"id":2142,"sortIndex":32,"affiliation":2159,"properties":28},{"id":2142,"createTime":28,"updateTime":28,"relativeEntities":2160,"slug":28,"properties":2161,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2163,"statistic":28},[],{"title":2162},{"EN":2147},[],{"title":2165,"openalex":2167},{"EN":2166},"G. 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De Beule",{"VOID":2232},"A5043432216",{"url":28,"publisher":2234,"properties":2280},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":2235,"slug":872,"properties":2236,"entityType":25,"verifyStatus":883,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":2241,"manageAffiliations":2254,"indexDatabases":2265,"url":950,"thumbnailPath":28,"statistic":28,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"country":2237,"eissn":2238,"issn":2239,"title":2240},{"VOID":875},{"VOID":877},{"VOID":879},{"EN":872},[2242,2246,2250],{"id":886,"createTime":28,"updateTime":28,"relativeEntities":2243,"label":2244,"description":2245,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":889},{},{"id":892,"createTime":28,"updateTime":28,"relativeEntities":2247,"label":2248,"description":2249,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":895},{},{"id":898,"createTime":28,"updateTime":28,"relativeEntities":2251,"label":2252,"description":2253,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":901},{},[2255,2260],{"id":905,"createTime":28,"updateTime":28,"relativeEntities":2256,"slug":28,"properties":2257,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2259,"statistic":28},[],{"title":2258},{"EN":909},[],{"id":912,"createTime":28,"updateTime":28,"relativeEntities":2261,"slug":28,"properties":2262,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2264,"statistic":28},[],{"title":2263},{"EN":916},[],[2266,2273],{"id":920,"indexDatabase":2267,"url":932,"indexYears":28,"academicFieldIds":2272,"indexDatabaseRanking":28},{"id":922,"createTime":28,"updateTime":28,"relativeEntities":2268,"label":2269,"description":2270,"key":929,"publicationTags":2271,"standard":28},[],{"EN":925,"VI":925},{"EN":927,"VI":928},[931,813],[934,935],{"id":937,"indexDatabase":2274,"url":943,"indexYears":944,"academicFieldIds":2279,"indexDatabaseRanking":949},{"id":775,"createTime":28,"updateTime":28,"relativeEntities":2275,"label":2276,"description":2277,"key":781,"publicationTags":2278,"standard":28},[],{"EN":778,"VI":778},{"EN":778,"VI":780},[783],[946,947,948],{"issue":2281,"pages":2282,"volume":2284},{"VOID":1177},{"VOID":2283},"103-108",{"VOID":1181},{"total":570,"publishYear":1184,"statisticByYear":2286},{"2012":45,"2013":48,"2014":48,"2015":123,"2016":123,"2017":40,"2018":123,"2019":123,"2020":46,"2021":42,"2023":40,"2024":40},[949,931],[2289,2292,2296,2299,2302,2306,2308],{"id":28,"text":2290,"url":28,"identifiers":2291},"Boogaerts M.A., 1988, Problems of infection treatment in immunocomuromised Datients, Res. Clin. Forums, 10, 10",{},{"id":28,"text":2293,"url":28,"identifiers":2294},"Booaaerts M.A., 1989, Risks of selective decontamination of the digesthe tract, Acta Clinica Belgica, 44, 83, 10.1080\u002F17843286.1989.11717994",{"doi":2295},"10.1080\u002F17843286.1989.11717994",{"id":28,"text":2297,"url":28,"identifiers":2298},"Boogaerts M.A., 1988, Itraconazole prophylaxis of invasive fungal infection in prolonged neutropenia, Proc. ICAAC, 210",{},{"id":28,"text":2300,"url":28,"identifiers":2301},"10.7326\u002F0003-4819-100-3-345",{"doi":2300},{"id":28,"text":2303,"url":28,"identifiers":2304},"Hawkins C., 1984, Fungal infections in the immunocompromised host, Clin. Haematol., 13, 599, 10.1016\u002FS0308-2261(21)00447-1",{"doi":2305},"10.1016\u002FS0308-2261(21)00447-1",{"id":28,"text":1306,"url":28,"identifiers":2307},{"doi":1306},{"id":28,"text":2309,"url":28,"identifiers":2310},"10.1128\u002FAAC.26.4.527",{"doi":2309},{"id":2312,"createTime":2313,"updateTime":2314,"relativeEntities":2315,"slug":2316,"properties":2317,"entityType":978,"verifyStatus":26,"verifyTime":2334,"verifyNote":979,"languages":2335,"translateLanguages":2336,"viewCount":32,"primaryUrl":2337,"fullTextUrl":28,"authors":2338,"publicationType":1127,"publisherRelationship":2457,"citationCount":359,"citationInfo":2511,"publishDate":2514,"publishYear":2512,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":2515,"openAccess":28,"references":2516,"isForceReanalyzing":1335},"c423241d-4210-4567-83ab-1bfdf74bb86e","2024-10-02T06:35:10.446+00:00","2025-02-23T01:43:14.170+00:00",[],"The-Treatment-of-Aspergillosis-and-Aspergilloma-with-Itraconazole-Clinical-Results-of-an-Open-International-Study-1982-1987-Die-Behandlung-der-Aspergillose-und-des-Aspergilloms-mit-Itraconazol-Klinische-Ergebnisse-einer-offenen-internationalen-Studie-1982-1987-",{"mag":2318,"keywords":2320,"openalex":2322,"abstract":2324,"title":2327,"pm":2330,"doi":2332},{"VOID":2319},"2153515355",{"VI":2321},"",{"VOID":2323},"W2153515355",{"EN":2325,"VI":2326},"\u003Cjats:p>\u003Cjats:bold>Summary:\u003C\u002Fjats:bold>A total of 137 patients with aspergillosis or aspergilloma has been treated with 50 to 400 mg itraconazole daily during 11 to 780 days.\u003C\u002Fjats:p>\u003Cjats:p>The global assessments »markedly improved« and »cured« were given to 60% of the treatments in invasive aspergillosis (n = 35) and reached 66% in chronic necrotising pulmonary aspergillosis (n = 44). These response rates are sufficiently high regarding the limited number of antifungal agents useful in aspergillosis. Sixty‐two percent of the chronic pulmonary aspergilloma cases (n = 42) showed symptomatic improvement and the radiological picture had improved in 30%. In one patient, the fungus ball disappeared during long‐term treatment. The results in five allergic bronchopulmonary aspergillosis (ABPA) patients indicate a possible role for itraconazole as complementary treatment to corticosteroids. All seven patients with cutaneous aspergillosis were mycologically and clinically cured after a maximum of 158 days of treatment. Two out of three biopsy proven cases of bone aspergillosis responded to itraconazole therapy. These long‐term treatments with itraconazole were well tolerated. The reported side effects were merely of gastro‐intestinal origin and there was no effect on the most important biochemical and haematological parameters.\u003C\u002Fjats:p>\u003Cjats:p>Itraconazole appears to be a valuable new tool in the treatment of aspergillosis.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Zusammenfassung:\u003C\u002Fjats:bold>Eine Gesamtzahl von 137 Aspergillose‐ und Aspergillom‐Patienten wurde mit 50–400 mg Itraconazol täglich über Perioden zwischen 11 und 780 Tagen behandelt.\u003C\u002Fjats:p>\u003Cjats:p>Das Globalurteil »wesentlich gebessert« oder »geheilt« erhielten 60% der Behandelten mit invasiver Aspergillose (n = 35) und 66% der Patienten mit chronisch nekrotisierender Lungenaspergillose (n = 44). Diese Ansprechquoten sind recht hoch, wenn man die beschränkte Anzahl der bei Aspergillose wirksamen Antimykotika berücksichtigt. Bei 62% der Fälle mit chronischem Lungenaspergillom (n = 42) wurde eine symptomatische Besserung erzielt, bei 30% besserte sich das radiologische Bild. Bei einem Patienten verschwand der Fungusball während Langzeitbehandlung. Die Ergebnisse von 5 Patienten mit allergischer bronchopulmonaler Aspergilose (ABPA) deuten auf die mögliche Rolle von Itraconazol bei einer Kombinationsbehandlung mit Kortikosteroiden. Alle 7 Patienten mit kutaner Aspergillose waren nach einer maximalen Behandlungsdauer von 158 Tagen mykologisch und klinisch geheilt. Zwei von 3 bioptisch nachgewiesenen Fällen mit Knochenaspergillose sprachen auf Itraconazol‐Behandlung an. Die Langzeitbehandlung mit Itraconazol war gut verträglich. Die angegebenen Nebenwirkungen waren meist gastrointestinalen Ursprunges, die wesentlichsten biochemischen und hämatologischen Parameter blieben unbeeinflußt. Damit erweist sich Itraconazol als ein wertvolles neues Medikament bei der Behandlung der Aspergillose.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>Tóm tắt:\u003C\u002Fjats:bold>Tổng cộng có 137 bệnh nhân mắc bệnh aspergillosis hoặc aspergilloma đã được điều trị bằng Itraconazole liều 50 đến 400 mg mỗi ngày trong khoảng thời gian từ 11 đến 780 ngày.\u003C\u002Fjats:p>\u003Cjats:p>Các đánh giá tổng quát \"cải thiện đáng kể\" và \"được chữa khỏi\" đã được đưa ra cho 60% các trường hợp điều trị mắc aspergillosis xâm lấn (n = 35) và đạt 66% trong trường hợp aspergillosis phổi hoại tử mãn tính (n = 44). Tỷ lệ phản ứng này là khá cao xét về số lượng thuốc chống nấm hạn chế hữu ích trong việc điều trị aspergillosis. Sáu mươi hai phần trăm các trường hợp tổn thương phổi mãn tính do aspergilloma (n = 42) đã cho thấy sự cải thiện triệu chứng và hình ảnh học đã cải thiện ở 30%. Ở một bệnh nhân, khối nấm đã biến mất trong suốt quá trình điều trị dài hạn. Kết quả ở năm bệnh nhân mắc bệnh dị ứng phế quản phổi do aspergillosis (ABPA) cho thấy một vai trò có thể của Itraconazole như một liệu pháp bổ sung cho corticosteroid. Tất cả bảy bệnh nhân mắc bệnh aspergillosis da đã được chữa khỏi mycologically và lâm sàng sau tối đa 158 ngày điều trị. Hai trong số ba trường hợp đã được sinh thiết xem là có bệnh aspergillosis xương đã phản ứng tích cực với liệu pháp Itraconazole. Các liệu pháp điều trị dài hạn bằng Itraconazole đều được dung nạp tốt. Các tác dụng phụ được báo cáo chủ yếu có nguồn gốc từ đường tiêu hóa và không có tác động đến các chỉ số sinh hóa và huyết học quan trọng nhất.\u003C\u002Fjats:p>\u003Cjats:p>Itraconazole dường như là một công cụ mới có giá trị trong việc điều trị aspergillosis.\u003C\u002Fjats:p>",{"EN":2328,"VI":2329},"The Treatment of Aspergillosis and Aspergilloma with Itraconazole, Clinical Results of an Open International Study (1982 ‐ 1987)\u002FDie Behandlung der Aspergillose und des Aspergilloms mit Itraconazol, Klinische Ergebnisse einer offenen internationalen Studie (1982 ‐ 1987)","Điều trị Aspergillosis và Aspergilloma bằng Itraconazole, Kết quả lâm sàng của một Nghiên cứu Quốc tế Mở (1982 - 1987)",{"VOID":2331},"2849056",{"VOID":2333},"10.1111\u002Fj.1439-0507.1988.tb03653.x","2024-10-02T06:35:10.445+00:00",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.1988.tb03653.x",[2339,2354,2369,2382,2397,2412,2427,2442],{"id":2340,"sortIndex":32,"researcher":28,"roles":2341,"affiliations":2342,"properties":2351,"displayName":2230,"givenName":28,"familyName":28},"4f8ed6df-9200-485b-a9db-3d5250f8802d",[],[2343],{"id":2344,"sortIndex":32,"affiliation":2345,"properties":28},"a91400f1-891f-45d4-9746-427c5758567f",{"id":2344,"createTime":28,"updateTime":28,"relativeEntities":2346,"slug":28,"properties":2347,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2350,"statistic":28},[],{"title":2348},{"EN":2349},"Janssen Research Foundation Worldwide, Beerse, Belgium",[],{"title":2352,"openalex":2353},{"EN":2230},{"VOID":2232},{"id":2355,"sortIndex":40,"researcher":28,"roles":2356,"affiliations":2357,"properties":2364,"displayName":2366,"givenName":28,"familyName":28},"d2c289a7-776e-468b-b0e9-30b49517c1e0",[],[2358],{"id":2344,"sortIndex":32,"affiliation":2359,"properties":28},{"id":2344,"createTime":28,"updateTime":28,"relativeEntities":2360,"slug":28,"properties":2361,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2363,"statistic":28},[],{"title":2362},{"EN":2349},[],{"title":2365,"openalex":2367},{"EN":2366},"Piet De Doncker",{"VOID":2368},"A5001320577",{"id":2370,"sortIndex":123,"researcher":28,"roles":2371,"affiliations":2372,"properties":2379,"displayName":1124,"givenName":28,"familyName":28},"f97e9e9e-f564-45ae-a255-d700b7f5c043",[],[2373],{"id":2344,"sortIndex":32,"affiliation":2374,"properties":28},{"id":2344,"createTime":28,"updateTime":28,"relativeEntities":2375,"slug":28,"properties":2376,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2378,"statistic":28},[],{"title":2377},{"EN":2349},[],{"title":2380,"openalex":2381},{"EN":1124},{"VOID":1126},{"id":2383,"sortIndex":42,"researcher":28,"roles":2384,"affiliations":2385,"properties":2392,"displayName":2394,"givenName":28,"familyName":28},"133914a2-0056-4aa1-8244-a98645dc4fa7",[],[2386],{"id":2344,"sortIndex":32,"affiliation":2387,"properties":28},{"id":2344,"createTime":28,"updateTime":28,"relativeEntities":2388,"slug":28,"properties":2389,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2391,"statistic":28},[],{"title":2390},{"EN":2349},[],{"title":2393,"openalex":2395},{"EN":2394},"M. 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A., 1987, Experience with itraconazole in deep mycoses in Northern Italy, Mykosen, 30, 23, 10.1111\u002Fj.1439-0507.1987.tb03973.x",{"doi":2546},"10.1111\u002Fj.1439-0507.1987.tb03973.x",{"id":28,"text":2548,"url":28,"identifiers":2549},"10.1007\u002F978-1-4899-3505-2_9",{"doi":2548},{"id":28,"text":2551,"url":28,"identifiers":2552},"Restrepo A., 1988, Aspergillus and aspergillosis, 252",{},{"id":28,"text":2554,"url":28,"identifiers":2555},"10.1007\u002F978-1-4899-3505-2_7",{"doi":2554},{"id":28,"text":2557,"url":28,"identifiers":2558},"10.1007\u002F978-1-4899-3505-2_4",{"doi":2557},{"id":2560,"createTime":2561,"updateTime":2562,"relativeEntities":2563,"slug":2564,"properties":2565,"entityType":978,"verifyStatus":26,"verifyTime":2561,"verifyNote":979,"languages":2583,"translateLanguages":2584,"viewCount":32,"primaryUrl":2585,"fullTextUrl":28,"authors":2586,"publicationType":1127,"publisherRelationship":2702,"citationCount":2756,"citationInfo":2757,"publishDate":2760,"publishYear":2758,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":2761,"openAccess":28,"references":2762,"isForceReanalyzing":1335},"aba63e46-8c67-4e1b-91f9-d8d5b7770da0","2024-10-11T05:48:31.960+00:00","2025-02-05T08:26:51.449+00:00",[],"Adverse-interactions-between-antifungal-azoles-and-vincristine-review-and-analysis-of-cases",{"mag":2566,"keywords":2568,"pmc":2569,"openalex":2571,"abstract":2573,"title":2576,"pm":2579,"doi":2581},{"VOID":2567},"2140134181",{"VI":2321},{"VOID":2570},"3345292",{"VOID":2572},"W2140134181",{"VI":2574,"EN":2575},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Các tác nhân chống nấm triazole và imidazole ức chế quá trình chuyển hóa của vincristine, dẫn đến việc phơi nhiễm quá mức với các alkaloid vinca và các tác động độc thần kinh nghiêm trọng. Các báo cáo gần đây về những tương tác làm suy nhược giữa vincristine và itraconazole, cũng như posaconazole, voriconazole và ketoconazole nhấn mạnh sự cần thiết phải nâng cao nhận thức y học về sự kết hợp bất lợi này. Vì vậy, chúng tôi đã thực hiện một phân tích toàn diện các báo cáo về tương tác thuốc bất lợi (ADI) với sự kết hợp giữa vincristine và các tác nhân chống nấm azole, thiết lập một phân loại mới và cung cấp một tóm tắt chi tiết về các độc tính này. Trong số những bệnh nhân có đủ dữ liệu để phân tích, 47 cá nhân đã được xác định có ADI với sự kết hợp của vincristine và các azole chống nấm. Tuổi trung bình là 8 năm (1,3–68 năm), trong đó 33 (70%) có chẩn đoán bệnh bạch cầu lymphoblast cấp tính. Thời gian trung vị đến ADI với vincristine là 9,5 ngày với itraconazole, 13,5 ngày với posaconazole và 30 ngày với voriconazole. Số lượng vincristine được tiêm trước khi có ADI trung vị là 2 liều với itraconazole, 3 liều với posaconazole và 2 liều với voriconazole. Các ADI nghiêm trọng phổ biến nhất bao gồm độc tính đường tiêu hóa, bệnh thần kinh ngoại biên, hạ natri máu\u002FSIADH, bệnh thần kinh tự chủ và co giật. Sự hồi phục từ các ADI này xảy ra ở 80,6% bệnh nhân. Chúng tôi khuyến cáo sử dụng các tác nhân chống nấm thay thế nếu có thể ở những bệnh nhân nhận vincristine để tránh tương tác thuốc nghiêm trọng và có khả năng đe dọa tính mạng này.\u003C\u002Fjats:p>","\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Triazole and imidazole antifungal agents inhibit metabolism of vincristine, leading to excess vinca alkaloid exposure and severe neurotoxicity. Recent reports of debilitating interactions between vincristine and itraconazole, as well as posaconazole, voriconazole and ketoconazole underscore the need to improve medical awareness of this adverse combination. We, therefore, undertook a comprehensive analysis of reports of adverse drug interactions (ADIs) with the combination of vincristine and azole antifungal agents, established a new classification, and provided a detailed summary of these toxicities. In patients who had sufficient data for analysis, 47 individuals were identified who had an ADI with the combination of vincristine and antifungal azoles. Median age was 8 years (1.3–68 years) with 33(70%) having a diagnosis of acute lymphoblastic leukaemia. Median time to ADI with vincristine was 9.5 days with itraconazole, 13.5 days posaconazole and 30 days voriconazole. The median number of vincristine doses preceding the ADI was 2 doses with itraconazole, 3 doses posaconazole and 2 doses voriconazole. The most common severe ADIs included gastrointestinal toxicity, peripheral neuropathy, hyponatremia\u002FSIADH, autonomic neuropathy and seizures. Recovery from these ADIs occurred in 80.6% of patients. 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infants and children, Antimicrob Agents Chemother, 42, 404, 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the present report we reviewed a total of 2397 cases of dermatophytosis from superficial cutaneous lesions between the years 1978 and 1990. The cases included were from the Department of Dermatology at the University Hospital located in the city of Monterrey, México. A total of 726 tinea pedis, 613 tinea unguium, 441 tinea capitis, 395 tinea corporis and 222 tinea cruris cases were observed. The most commonly isolated dermatophyte species was \u003Cjats:italic>Trichophyton rubrum\u003C\u002Fjats:italic> (45%), followed by \u003Cjats:italic>Trichophyton mentagrophytes\u003C\u002Fjats:italic> (23.7%), \u003Cjats:italic>Trichophyton tonsurans\u003C\u002Fjats:italic> (21%), \u003Cjats:italic>Microsporum canis\u003C\u002Fjats:italic> (7.1%) and \u003Cjats:italic>Epidermophyton floccosum\u003C\u002Fjats:italic> (2.5%). Less frequently we isolated \u003Cjats:italic>Microsporum audouinii\u003C\u002Fjats:italic>, \u003Cjats:italic>Microsporum gypseum\u003C\u002Fjats:italic>, \u003Cjats:italic>Trichophyton violaceum\u003C\u002Fjats:italic> and \u003Cjats:italic>Trichophyton verrucosum\u003C\u002Fjats:italic>. Most of the cases were observed in the warmest months of the year (from March to September), and were equally distributed in both genders, except for tinea cruris which was more prevalent in men (3.5 : 1 ratio).\u003C\u002Fjats:p>",{"EN":2894},"Dermatophytoses in Monterrey, México",{"VOID":2896},"16466445",{"VOID":2898},"10.1111\u002Fj.1439-0507.2006.01199.x","2024-10-10T00:34:55.793+00:00",[31],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.2006.01199.x",[2903,2922,2939,2956,2971],{"id":2904,"sortIndex":32,"researcher":28,"roles":2905,"affiliations":2906,"properties":2915,"displayName":2919,"givenName":28,"familyName":28},"d77b8c92-2dcc-49f4-a9c9-dfb5cf0ee2ff",[],[2907],{"id":2908,"sortIndex":32,"affiliation":2909,"properties":28},"666a1d85-cd0d-499a-9403-88b44749594b",{"id":2908,"createTime":28,"updateTime":28,"relativeEntities":2910,"slug":28,"properties":2911,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2914,"statistic":28},[],{"title":2912},{"EN":2913},"Servicio de Dermatología, Hospital Universitario ‘José E. 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R, 1999, Primer Consenso micosis superficiales, Dermatol Rev Mex, 43, 80",{},{"id":28,"text":3055,"url":28,"identifiers":3056},"Mayorga JA, 1995, Dermatofitosis: Estudio epidemiológico en el instituto dermatológico de Jalisco (1984–1993), Dermatol Rev Mex, 39, 18",{},{"id":28,"text":3058,"url":28,"identifiers":3059},"10.1111\u002Fj.1439-0507.1994.tb00285.x",{"doi":3058},{"id":28,"text":3061,"url":28,"identifiers":3062},"10.1111\u002Fj.1365-4362.1974.tb05086.x",{"doi":3061},{"id":28,"text":3064,"url":28,"identifiers":3065},"Kasai T, 2000, 1996 epidemiological survey of dermatophytoses in Japan. Epidemiological Investigation Committee for Human Mycoses in the Japanese Society for Medical Mycology, Nippon Ishinkin Gakkai Zasshi, 41, 187",{},{"id":28,"text":3067,"url":28,"identifiers":3068},"10.1016\u002FS0190-9622(03)02117-0",{"doi":3067},{"id":28,"text":3070,"url":28,"identifiers":3071},"10.1046\u002Fj.1439-0507.2001.00697.x",{"doi":3070},{"id":28,"text":3073,"url":28,"identifiers":3074},"Barisic‐Drusko V, 2003, Epidemiology of dermatomycosis in the eastern Croatia – today and yesterday, Coll Antropol, 27, 11",{},{"id":28,"text":3076,"url":28,"identifiers":3077},"10.1023\u002FB:MYCO.0000003560.65857.cf",{"doi":3076},{"id":28,"text":3079,"url":28,"identifiers":3080},"10.1046\u002Fj.1439-0507.2003.00891.x",{"doi":3079},{"id":28,"text":3082,"url":28,"identifiers":3083},"10.1111\u002Fj.1365-4362.1993.tb00961.x",{"doi":3082},{"id":28,"text":3085,"url":28,"identifiers":3086},"10.1111\u002Fj.0736-8046.2004.21404.x",{"doi":3085},{"id":28,"text":3088,"url":28,"identifiers":3089},"Arenas R, 2002, Dermatophytoses in Mexico, Rev Iberoam Micol, 19, 63",{},{"id":28,"text":3091,"url":28,"identifiers":3092},"Segundo C, 2004, Dermatomicosis por Microsporum canis en humanos y animales, Rev Iberoam Micol, 21, 39",{},{"id":28,"text":3094,"url":28,"identifiers":3095},"10.1016\u002FS0213-9251(03)72743-9",{"doi":3094},{"id":28,"text":3097,"url":28,"identifiers":3098},"Bonifaz A, 1995, Tiña del cuero cabelludo en adultos, Rev Iberoam Micol, 12, 75",{},{"id":28,"text":3100,"url":28,"identifiers":3101},"Bonifaz A, 1996, Estudio clínico‐micológico de 125 casos de tiña de la cabeza, Bol Med Hosp Infant Mex, 53, 72",{},{"id":28,"text":3103,"url":28,"identifiers":3104},"Mayorga J, 1999, Tiña de la cabeza. Observaciones clínico‐micológicas en 30 pacientes, Dermatol Rev Mex, 43, 264",{},{"id":3106,"createTime":3107,"updateTime":3108,"relativeEntities":3109,"slug":3110,"properties":3111,"entityType":978,"verifyStatus":26,"verifyTime":3107,"verifyNote":979,"languages":3127,"translateLanguages":3128,"viewCount":32,"primaryUrl":3129,"fullTextUrl":28,"authors":3130,"publicationType":1127,"publisherRelationship":3282,"citationCount":159,"citationInfo":3335,"publishDate":3337,"publishYear":3043,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":3338,"openAccess":28,"references":3339,"isForceReanalyzing":1335},"715d0960-ce18-40bb-8256-15422e03d1c9","2024-10-01T13:01:02.105+00:00","2025-02-23T01:44:12.636+00:00",[],"Pseudomembranous-and-obstructive-i-Aspergillus-i-tracheobronchitis-optimal-diagnostic-strategy-and-outcome",{"mag":3112,"keywords":3114,"openalex":3115,"abstract":3117,"title":3120,"pm":3123,"doi":3125},{"VOID":3113},"1986528608",{"VI":2321},{"VOID":3116},"W1986528608",{"EN":3118,"VI":3119},"\u003Cjats:title>Summary\u003C\u002Fjats:title>\u003Cjats:p>Pseudomembranous and obstructive \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> tracheobronchitis (PMATB\u002FOATB) are still considered to be refractory to therapy and to have a fatal outcome. To evaluate the optimal diagnostic strategy and to describe factors affecting the outcome of PMATB and OATB. Retrospective analysis of four new cases of PMATB and OATB combined with 16 previously reported cases over a 10‐year period (1995–2004). Among the four new cases reported and the 16 published cases, four patients survived their infection. The mortality rate was significantly higher in the group of ventilated patients [94% (15 of 16 patients)] than in the group of non‐ventilated patients [25% (1 of 4 patients), \u003Cjats:italic>P\u003C\u002Fjats:italic> &lt; 0.05, Fisher's exact test]. In all 20 patients, diagnosis was established by bronchoscopy. Culture examination of mucous plugs was positive in 8 of 10, culture of the tracheobronchial aspirate was positive in 8 of 12, and bronchoalveolar lavage was diagnostic in 7 of 13 patients. All bronchoscopic techniques were complementary in improving the yield of bronchoscopy. However, microscopy of mucous plugs and\u002For necrotic material was the best diagnostic modality [positive in 94% (17 of 18 patients)]. Prognosis of PMATB and OATB remains poor. Microscopy of respiratory specimens is the most sensitive tool to confirm the diagnosis. The characteristic appearance of the disease makes it possible to start antifungal therapy immediately.\u003C\u002Fjats:p>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:p>Tracheobronchitis giả màng và tắc nghẽn do \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> (PMATB\u002FOATB) vẫn được coi là khó điều trị và có thể dẫn đến tử vong. Mục tiêu của nghiên cứu này là đánh giá chiến lược chẩn đoán tối ưu và mô tả các yếu tố ảnh hưởng đến kết quả của PMATB và OATB. Phân tích hồi cứu bốn trường hợp PMATB và OATB mới kết hợp với 16 trường hợp đã được báo cáo trước đó trong khoảng thời gian 10 năm (1995–2004). Trong số bốn trường hợp mới báo cáo và 16 trường hợp đã công bố, có bốn bệnh nhân sống sót sau khi nhiễm bệnh. Tỷ lệ tử vong ở nhóm bệnh nhân thở máy là đáng kể hơn [94% (15 trên 16 bệnh nhân)] so với nhóm bệnh nhân không thở máy [25% (1 trên 4 bệnh nhân), \u003Cjats:italic>P\u003C\u002Fjats:italic> &lt 0.05, kiểm định chính xác Fisher]. Ở tất cả 20 bệnh nhân, chẩn đoán được thiết lập thông qua nội soi phế quản. Xét nghiệm nuôi cấy mảnh nhầy có kết quả dương tính trong 8 trên 10 trường hợp, nuôi cấy dịch rửa khí quản phế quản có kết quả dương tính trong 8 trên 12 trường hợp, và rửa phế quản phế nang có chẩn đoán trong 7 trên 13 bệnh nhân. Tất cả các kỹ thuật nội soi phế quản đều bổ sung cho nhau trong việc cải thiện tỷ lệ chẩn đoán của nội soi phế quản. Tuy nhiên, viễn thị mảnh nhầy và\u002Fhoặc vật liệu hoại tử là phương pháp chẩn đoán tốt nhất [dương tính trong 94% (17 trên 18 bệnh nhân)]. Tiên lượng cho PMATB và OATB vẫn kém. Viễn thị các mẫu bệnh phẩm đường hô hấp là công cụ nhạy nhất để xác nhận chẩn đoán. Đặc điểm hình thái của bệnh cho phép bắt đầu điều trị kháng nấm ngay lập tức.\u003C\u002Fjats:p>",{"EN":3121,"VI":3122},"Pseudomembranous and obstructive \u003Ci>Aspergillus\u003C\u002Fi> tracheobronchitis – optimal diagnostic strategy and outcome","Tracheobronchitis do \u003Ci>Aspergillus\u003C\u002Fi> giả màng và tắc nghẽn – chiến lược chẩn đoán tối ưu và kết quả",{"VOID":3124},"16367817",{"VOID":3126},"10.1111\u002Fj.1439-0507.2005.01180.x",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.2005.01180.x",[3131,3148,3165,3180,3197,3214,3233,3250,3265],{"id":3132,"sortIndex":32,"researcher":28,"roles":3133,"affiliations":3134,"properties":3143,"displayName":3145,"givenName":28,"familyName":28},"0d738e3a-eeaf-43fc-ac0c-8237ac880209",[],[3135],{"id":3136,"sortIndex":32,"affiliation":3137,"properties":28},"a08ab480-2ba8-4cc5-81ed-a8e50d4ec98b",{"id":3136,"createTime":28,"updateTime":28,"relativeEntities":3138,"slug":28,"properties":3139,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3142,"statistic":28},[],{"title":3140},{"VI":3141},"Department of Internal Medicine II",[],{"title":3144,"openalex":3146},{"EN":3145},"Selçuk Tasci",{"VOID":3147},"A5017118136",{"id":3149,"sortIndex":40,"researcher":28,"roles":3150,"affiliations":3151,"properties":3160,"displayName":3162,"givenName":28,"familyName":28},"f60af5d1-a821-4b8c-a602-8abd9cd216a1",[],[3152],{"id":3153,"sortIndex":32,"affiliation":3154,"properties":28},"c0e718e7-0187-4e05-a190-8e3ff4482fe0",{"id":3153,"createTime":28,"updateTime":28,"relativeEntities":3155,"slug":28,"properties":3156,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3159,"statistic":28},[],{"title":3157},{"VI":3158},"Department of Internal Medicine I",[],{"title":3161,"openalex":3163},{"EN":3162},"Axel Glasmacher",{"VOID":3164},"A5065213472",{"id":3166,"sortIndex":123,"researcher":28,"roles":3167,"affiliations":3168,"properties":3175,"displayName":3177,"givenName":28,"familyName":28},"a68ba163-448d-4c30-9d78-418a27e9b112",[],[3169],{"id":3136,"sortIndex":32,"affiliation":3170,"properties":28},{"id":3136,"createTime":28,"updateTime":28,"relativeEntities":3171,"slug":28,"properties":3172,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3174,"statistic":28},[],{"title":3173},{"VI":3141},[],{"title":3176,"openalex":3178},{"EN":3177},"Silvia Lentini",{"VOID":3179},"A5104729067",{"id":3181,"sortIndex":42,"researcher":28,"roles":3182,"affiliations":3183,"properties":3192,"displayName":3194,"givenName":28,"familyName":28},"b4e823c7-4133-45e3-9bae-ff5b4cd1a3ff",[],[3184],{"id":3185,"sortIndex":32,"affiliation":3186,"properties":28},"38b502fb-5dcf-421a-a35f-a4d5122d86be",{"id":3185,"createTime":28,"updateTime":28,"relativeEntities":3187,"slug":28,"properties":3188,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3191,"statistic":28},[],{"title":3189},{"EN":3190},"Department of Pathology; University of Bonn; Bonn",[],{"title":3193,"openalex":3195},{"EN":3194},"K. 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Their Recognition and Identification",{},{"id":28,"text":3591,"url":28,"identifiers":3592},"Kurtzman, 1998, The Yeasts, a Taxonomic Study",{},{"id":28,"text":3594,"url":28,"identifiers":3595},"Koussidou, 2002, Onychomycosis in Northern Greece during 1994â1998, Mycoses, 45, 29, 10.1046\u002Fj.1439-0507.2002.00705.x",{"doi":3596},"10.1046\u002Fj.1439-0507.2002.00705.x",{"id":28,"text":3598,"url":28,"identifiers":3599},"Madhuri, 2002, Onychomychosis: a significant medical problem, Indian J Dermatol Venereol Leprol, 68, 326",{},{"id":28,"text":3601,"url":28,"identifiers":3602},"Ogasawa, 2003, Clinical and mycological study of occult tinea pedis and tinea unguium in dermatological patients from Tokyo, Mycoses, 46, 114, 10.1046\u002Fj.1439-0507.2003.00855.x",{"doi":3603},"10.1046\u002Fj.1439-0507.2003.00855.x",{"id":28,"text":3605,"url":28,"identifiers":3606},"Lopes, 1999, A ten-year survey of onychomycosis in the Central Region of the Rio Grande do Sul, Brazil, Rev Inst Med Trop Sao Paulo, 41, 147, 10.1590\u002FS0036-46651999000300002",{"doi":3607},"10.1590\u002FS0036-46651999000300002",{"id":28,"text":3609,"url":28,"identifiers":3610},"El Sayed, 2006, Onychomychosis in Lebanon: a mycological survey of 772 patients, Mycoses, 49, 216, 10.1111\u002Fj.1439-0507.2006.01224.x",{"doi":3611},"10.1111\u002Fj.1439-0507.2006.01224.x",{"id":28,"text":3613,"url":28,"identifiers":3614},"Sigurgeirsson, 2004, Risk factors associated with onychomycosis, J Eur Acad Dermatol Venereol, 18, 48, 10.1111\u002Fj.1468-3083.2004.00851.x",{"doi":3615},"10.1111\u002Fj.1468-3083.2004.00851.x",{"id":28,"text":3617,"url":28,"identifiers":3618},"Watanabe, 1983, Nail candidiasis, J Dermatol (Tokio), 10, 189, 10.1111\u002Fj.1346-8138.1983.tb01128.x",{"doi":3619},"10.1111\u002Fj.1346-8138.1983.tb01128.x",{"id":28,"text":3621,"url":28,"identifiers":3622},"Ellabib, 2002, Yeasts of genus Candida are dominant cause of onychomycosis in Libian women but not men: results of a 2-year surveillance study, Br J Dermatol, 146, 1038, 10.1046\u002Fj.1365-2133.2002.04688.x",{"doi":3623},"10.1046\u002Fj.1365-2133.2002.04688.x",{"id":28,"text":3625,"url":28,"identifiers":3626},"Rigopoulos, 1998, Epidemiology of onychomycosis in southern Greece, Int J Dermatol, 37, 925, 10.1046\u002Fj.1365-4362.1998.00613.x",{"doi":3627},"10.1046\u002Fj.1365-4362.1998.00613.x",{"id":28,"text":3629,"url":28,"identifiers":3630},"Costa, 1999, Etiologia e epidemiologia das dermatofitoses em GoiÃ¢nia, GO, Brasil, Rev Soc Bras Med Trop, 32, 367, 10.1590\u002FS0037-86821999000400006",{"doi":3631},"10.1590\u002FS0037-86821999000400006",{"id":28,"text":3633,"url":28,"identifiers":3634},"Costa, 2002, Epidemiologia e etiologia das dermatofitoses em GoiÃ¢nia, GO, Brasil, Rev Soc Bras Med Trop, 35, 19, 10.1590\u002FS0037-86822002000100004",{"doi":3635},"10.1590\u002FS0037-86822002000100004",{"id":28,"text":3637,"url":28,"identifiers":3638},"Han, 2000, Onychomycosis and Trichosporon beigelli in Korea, Int J Dermatol, 39, 266, 10.1046\u002Fj.1365-4362.2000.00910.x",{"doi":3639},"10.1046\u002Fj.1365-4362.2000.00910.x",{"id":28,"text":3641,"url":28,"identifiers":3642},"Gupta, 2000, Prevalence and epidemiology of onychomycosis in patients visiting physiciansâ offices: a multicenter Canadian survey of 15â000 patients, J Am Acad Dermatol, 43, 244, 10.1067\u002Fmjd.2000.104794",{"doi":3643},"10.1067\u002Fmjd.2000.104794",{"id":3645,"createTime":3646,"updateTime":3647,"relativeEntities":3648,"slug":3649,"properties":3650,"entityType":978,"verifyStatus":26,"verifyTime":3666,"verifyNote":979,"languages":3667,"translateLanguages":3668,"viewCount":32,"primaryUrl":3669,"fullTextUrl":28,"authors":3670,"publicationType":1127,"publisherRelationship":3735,"citationCount":206,"citationInfo":3788,"publishDate":3790,"publishYear":2512,"citationAnalyzeStatus":883,"lastCitationAnalyze":28,"indexDatabases":3791,"openAccess":28,"references":3792,"isForceReanalyzing":1335},"13355697-8aea-47ad-a8e3-793e5b5b6526","2024-10-02T06:34:59.504+00:00","2025-02-23T01:45:09.545+00:00",[],"Oral-Itraconazole-Therapy-for-Mycotic-Keratitis-Orale-Itraconazol-Therapie-bei-mykotischer-Keratitis",{"mag":3651,"keywords":3653,"openalex":3654,"abstract":3656,"title":3659,"pm":3662,"doi":3664},{"VOID":3652},"1965429232",{"VI":2321},{"VOID":3655},"W1965429232",{"EN":3657,"VI":3658},"\u003Cjats:p>\u003Cjats:bold>Summary: \u003C\u002Fjats:bold> Forty consecutive patients suffering from mycotic keratitis (19 due to \u003Cjats:italic>Fusarium solani\u003C\u002Fjats:italic> and other \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> spp., 15 due to \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> and \u003Cjats:italic>Aspergillus fumigatus\u003C\u002Fjats:italic> and six cases due to other fungi) were treated with itraconazole, a triazole derivative. The compound was administered orally once daily in a dose of 200 mg for a median duration of treatment of 17 days. Progressive corneal ulceration stopped and there was complete resolution of all lesions and eradication of the infecting fungus from the lesions in 22 patients. In five patients, the infecting fungi were eradicated from the lesions but ultimately surgery had to be performed due to incomplete resolution of the lesions. In the remaining 13 patients, progressive corneal ulceration continued and the infecting fungi (\u003Cjats:italic>F. solani\u003C\u002Fjats:italic> and other \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> spp. in nine patients, \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> in two patients, \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> in one and \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> spp. in one patient) were not eradicated from the lesion. Excellent or moderate responsiveness to therapy was observed more frequently in cases of keratitis due to \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> than in cases of keratitis due to \u003Cjats:italic>Fusarium.\u003C\u002Fjats:italic> There was no evidence of serious adverse reactions in any of the patients.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Zusammenfassung: \u003C\u002Fjats:bold> Vierzig Patienten mit mykotischer Keratitis (19 verursacht durch \u003Cjats:italic>Fusarium solani\u003C\u002Fjats:italic> und andere \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>‐Arten, 15 durch \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> und \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> und 6 durch andere Pilze) wurden mit dem Triazol‐Derivat Itraconazol behandelt. Das Mittel wurde einmal täglich in einer Dosis von 200 mg bei einer mittleren Behandlungsdauer von 17 d gegeben. Bei 22 Patienten kam die progrediente Hornhautulzeration zum Still‐stand, es kam zur vollständigen Ausheilung aller Läsionen und zur Eliminierung des Pilzes. Bei 5 Patienten konnte der Pilz eliminiert werden, jedoch mußte wegen der nur unvollständigen Abheilung der Läsionen chirurgisch nachbehandelt werden. Bei den restlichen 13 Patienten schritt die Hornhautulzeration weiter fort und der Erreger (\u003Cjats:italic>F. solani\u003C\u002Fjats:italic> und andere \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>‐Arten bei 9 Patienten, \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> bei 2 und \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> und \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> spec. in je einem Patienten) konnten nicht aus den Läsionen eliminiert werden. Hervorragendes und mäßiges Ansprechen auf die Therapie wurde Öfter bei \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic>‐bedingter als bei \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>‐bedingter Keratitis beobachtet. Ernsthafte Nebenwirkungen wurden bei keinem der Patienten gesehen.\u003C\u002Fjats:p>","\u003Cjats:p>\u003Cjats:bold>Tóm tắt: \u003C\u002Fjats:bold> Bốn mươi bệnh nhân liên tiếp mắc keratitis nấm (19 bệnh nhân do \u003Cjats:italic>Fusarium solani\u003C\u002Fjats:italic> và các loài \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> khác, 15 bệnh nhân do \u003Cjats:italic>Aspergillus flavus\u003C\u002Fjats:italic> và \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> và sáu trường hợp do các nấm khác) đã được điều trị bằng itraconazole, một dẫn xuất triazole. Chất này được dùng đường uống một lần mỗi ngày với liều 200 mg trong thời gian điều trị trung bình là 17 ngày. Sự loét tiến triển của giác mạc đã dừng lại và có sự giải quyết hoàn toàn của tất cả các tổn thương và tiêu diệt nấm gây bệnh khỏi tổn thương ở 22 bệnh nhân. Ở năm bệnh nhân, các nấm gây bệnh đã được tiêu diệt khỏi tổn thương nhưng cuối cùng phải thực hiện phẫu thuật do sự giải quyết chưa hoàn toàn của các tổn thương. Trong 13 bệnh nhân còn lại, sự loét giác mạc tiến triển vẫn tiếp tục và các nấm gây bệnh (\u003Cjats:italic>F. solani\u003C\u002Fjats:italic> và các loài \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic> khác ở chín bệnh nhân, \u003Cjats:italic>A. fumigatus\u003C\u002Fjats:italic> ở hai bệnh nhân, \u003Cjats:italic>A. flavus\u003C\u002Fjats:italic> ở một bệnh nhân và \u003Cjats:italic>Cladosporium\u003C\u002Fjats:italic> spp. ở một bệnh nhân) đã không được tiêu diệt khỏi tổn thương. Đáp ứng hoàn hảo hoặc trung bình đối với liệu pháp được quan sát thấy thường xuyên hơn trong các trường hợp keratitis do \u003Cjats:italic>Aspergillus\u003C\u002Fjats:italic> hơn là do \u003Cjats:italic>Fusarium\u003C\u002Fjats:italic>. Không có bằng chứng nào về các phản ứng phụ nghiêm trọng ở bất kỳ bệnh nhân nào.\u003C\u002Fjats:p>",{"EN":3660,"VI":3661},"Oral Itraconazole Therapy for Mycotic Keratitis\u002FOrale Itraconazol‐Therapie bei mykotischer Keratitis","Liệu pháp Itraconazole đường uống cho Keratitis mycotic",{"VOID":3663},"2843767",{"VOID":3665},"10.1111\u002Fj.1439-0507.1988.tb03986.x","2024-10-02T06:34:59.503+00:00",[31],[30],"https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1439-0507.1988.tb03986.x",[3671,3690,3705,3720],{"id":3672,"sortIndex":32,"researcher":28,"roles":3673,"affiliations":3674,"properties":3683,"displayName":3687,"givenName":28,"familyName":28},"1069020b-38cb-4895-9cc8-cb655c36fbbc",[],[3675],{"id":3676,"sortIndex":32,"affiliation":3677,"properties":28},"6ddf6ad5-19d5-4136-b94e-b4406a4fc302",{"id":3676,"createTime":28,"updateTime":28,"relativeEntities":3678,"slug":28,"properties":3679,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3682,"statistic":28},[],{"title":3680},{"EN":3681},"Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India",[],{"orcid":3684,"title":3686,"openalex":3688},{"VOID":3685},"https:\u002F\u002Forcid.org\u002F0000-0002-0585-0499",{"EN":3687},"Philip A. 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Cure was obtained in all cases after periods of 15–75 days (median 44 days) with total doses between 3.1 and 14.8 g (median 8.4 g). No serious side effects were observed and no relapses occurred in the follow‐up period of between 1 and 26 months (median 14.7). These results show that itraconazole represents a safe and effective drug for the treatment of sporotrichosis. Comparison with other studies leads us to consider a daily dose of 200 mg as the most appropriate. A concomitant warming of the affected limbs should be recommended.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Zusammenfassung. \u003C\u002Fjats:bold> Achtzehn männliche Erwachsene weißer Hautfarbe mit kutaner Sporotrichose wurden nach unterschiedlichen Dosierungsschemata mit Itraconazol behandelt. Eine Heilung wurde in allen Fällen nach einer Behandlungsdauer zwischen 15 und 75 d (Mittel 44 d) mit Gesamtdosen von 3.1 bis 14.8 g (Mittel 8.4 g) erzielt. Bedeutsame Nebenwirkungen wurden nicht beobachtet. In der Nachbeobachtungszeit, die mit einem Mittel von 14.7 Monaten zwischen einem und 26 Monaten lag, traten keine Rück‐fälle auf. Die Ergebnisse belegen, daß Itraconazol ein sicher wirksames Medikament für die Behandlung der Sporotrichose darstellt. Unter Einbeziehung der Ergebnisse anderer Studien erscheint uns eine tägliche Itraconazol‐Dosis von 200 mg als am günstigsten. 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