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Rev. Clin. Oncol., 15, 541, 10.1038\u002Fs41571-018-0035-x\nAntolín, 2015, Circulating miR-200c and miR-141 and outcomes in patients with breast cancer, BMC Canc., 15, 10.1186\u002Fs12885-015-1238-5\nBarbato, 2017, MicroRNAs in oncogenesis and tumor suppression, Int. Rev. Cell Mol. Biol., 333, 229, 10.1016\u002Fbs.ircmb.2017.05.001\nBartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016\u002FS0092-8674(04)00045-5\nBecker, 2015, The role of miR-200a in mammalian epithelial cell transformation, Carcinogenesis, 36, 2, 10.1093\u002Fcarcin\u002Fbgu202\nBhardwaj, 2017, MiRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma, Br. J. Ophthalmol., 101, 536, 10.1136\u002Fbjophthalmol-2016-309460\nBrozovic, 2015, The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells, Mol. Oncol., 9, 1678, 10.1016\u002Fj.molonc.2015.04.015\nByun, 2019, MiR-200c downregulates HIF-1alpha and inhibits migration of lung cancer cells, Cell. Mol. Biol. Lett., 24, 28, 10.1186\u002Fs11658-019-0152-2\nCao, 2014, Clinicopathological and prognostic implications of the miR-200 family in patients with epithelial ovarian cancer, Int. J. Clin. Exp. Pathol., 7, 2392\nChang, 2010, MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer, BMC Canc., 10, 173, 10.1186\u002F1471-2407-10-173\nChao, 2012, Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2, Oncogene, 31, 764, 10.1038\u002Fonc.2011.269\nCheng, 2011, Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis, PLoS One, 6, 10.1371\u002Fjournal.pone.0017745\nCroce, 2005, miRNAs, cancer, and stem cell division, Cell, 122, 6, 10.1016\u002Fj.cell.2005.06.036\nCrossland, 2016, Evaluation of optimal extracellular vesicle small RNA isolation and qRT-PCR normalisation for serum and urine, J. Immunol. Methods, 429, 39, 10.1016\u002Fj.jim.2015.12.011\nDebeb, 2016, miR-141-Mediated regulation of brain metastasis from breast cancer, J. Natl. 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Pract., 2013, 804128, 10.1155\u002F2013\u002F804128\nHumphries, 2017, ARHGAP18 downregulation by mir-200b suppresses metastasis of triple-negative breast cancer by enhancing activation of RhoA, Cancer Res., 77, 4051, 10.1158\u002F0008-5472.CAN-16-3141\nJiao, 2016, MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator, Mol. Med. Rep., 13, 3349, 10.3892\u002Fmmr.2016.4901\nJin, 2017, microRNA-200c\u002F141 upregulates SerpinB2 to promote breast cancer cell metastasis and reduce patient survival, Oncotarget, 8, 32769, 10.18632\u002Foncotarget.15680\nKim, 2014, Expression of microRNA miR-126 and miR-200c is associated with prognosis in patients with non-small cell lung cancer, Virchows Arch. : Int. J. Pathol., 465, 463, 10.1007\u002Fs00428-014-1640-4\nLeskelä, 2011, The miR-200 family controls β-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients, Endocr. Relat. Cancer, 18, 85, 10.1677\u002FERC-10-0148\nLi, 2017, The microRNAs miR-200b-3p and miR-429-5p target the LIMK1\u002FCFL1 pathway to inhibit growth and motility of breast cancer cells, Oncotarget, 8, 85276, 10.18632\u002Foncotarget.19205\nLi, 2019, MiR-141-3p functions as a tumor suppressor through directly targeting ZFR in non-small cell lung cancer, Biochem. Biophys. Res. Commun., 509, 647, 10.1016\u002Fj.bbrc.2018.12.089\nLi, 2013, MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2, Cancer Lett., 329, 84, 10.1016\u002Fj.canlet.2012.10.019\nLi, 2019, MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma, EBioMedicine, 44, 439, 10.1016\u002Fj.ebiom.2019.05.041\nLi, 2015, Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4, Gut, 64, 156, 10.1136\u002Fgutjnl-2013-305715\nLian, 2019, MicroRNA-183 and microRNA-141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma, Oncol. Lett., 17, 1172\nLin, 2017, Phase 2 study of circulating microRNA biomarkers in castration-resistant prostate cancer, Dis. Markers, 116, 1002\nLiu, 2018, Roles of miR-200 family members in lung cancer: more than tumor suppressors, Future Oncol.., 14, 2875, 10.2217\u002Ffon-2018-0155\nLiu, 2018, Correlation between mir-200 family overexpression and cancer prognosis, Dis. Markers, 2018, 6071826, 10.1155\u002F2018\u002F6071826\nLiu, 2012, High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer, Med. Oncol. (Northwood, London, England), 29, 618, 10.1007\u002Fs12032-011-9923-y\nLiu, 2014, MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1, PLoS One, 9\nLu, 2015, Prognostic value of miR-141 downregulation in gastric cancer, Genet. Mol. 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Cancer, 49, 520, 10.1016\u002Fj.ejca.2012.06.026\nMartinez-Ciarpaglini, 2019, Low miR200c expression in tumor budding of invasive front predicts worse survival in patients with localized colon cancer and is related to PD-L1 overexpression, Mod. Pathol., 32, 306, 10.1038\u002Fs41379-018-0124-5\nMeng, 2015, Diagnostic and prognostic potential of serum MIR-7, MIR-16, MIR-25, MIR-93, MIR-182, MIR-376a and MIR-429 in ovarian cancer patients, Br. J. Canc., 113, 1358, 10.1038\u002Fbjc.2015.340\nMeng, 2016, Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer, Oncotarget, 7, 16923, 10.18632\u002Foncotarget.7850\nMoher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, PLoS Med., 6, 10.1371\u002Fjournal.pmed.1000097\nMuralidhar, 2015, The mir-200 family: versatile players in epithelial ovarian cancer, Int. J. Mol. Sci., 16, 16833, 10.3390\u002Fijms160816833\nNing, 2018, miR-200b promotes cell proliferation and invasion in t-cell acute Lymphoblastic leukemia through NOTCH1, J. Biol. Regul. Homeost. Agents, 32, 1467\nPaik, 2015, MicroRNA-200c as a prognostic biomarker for pancreatic cancer, The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 66, 215, 10.4166\u002Fkjg.2015.66.4.215\nPan, 2018, WIPF1 antagonizes the tumor suppressive effect of miR-141\u002F200c and is associated with poor survival in patients with PDAC, J. Exp. Clin. Cancer Res. : CR (Clim. 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Scand., 95, 505, 10.1111\u002Faogs.12883\nSi, 2017, Potential use of microRNA-200c as a prognostic marker in non-small cell lung cancer, Oncol. lett., 14, 4325, 10.3892\u002Fol.2017.6667\nSilva-Santos, 2013, MicroRNA profile: a promising ancillary tool for accurate renal cell tumour diagnosis, Br. J. Canc., 109, 2646, 10.1038\u002Fbjc.2013.552\nSong, 2015, miR-429 determines poor outcome and inhibits pancreatic ductal adenocarcinoma growth by targeting TBK1, Cell. Physiol. Biochem. : Int. J. Exp. Cell. Physiol. Biochem. Pharmacol., 35, 1846, 10.1159\u002F000373995\nSong, 2015, miR-200c inhibits breast cancer proliferation by targeting KRAS, Oncotarget, 6, 34968, 10.18632\u002Foncotarget.5198\nSong, 2014, Integrated microRNA network analyses identify a poor-prognosis subtype of gastric cancer characterized by the miR-200 family, Clin. Cancer Res. : Off. J. Am. Assoc. Canc. Res., 20, 878, 10.1158\u002F1078-0432.CCR-13-1844\nSun, 2014, The role of miR-200a in vasculogenic mimicry and its clinical significance in ovarian cancer, Gynecol. Oncol., 132, 730, 10.1016\u002Fj.ygyno.2014.01.047\nSun, 2016, The potential prognostic value of MicroRNA-429 for human gliomas, Ann. Clin. Lab. Sci., 46, 44\nSun, 2016, Examining plasma microRNA markers for colorectal cancer at different stages, Oncotarget, 7, 11434, 10.18632\u002Foncotarget.7196\nTang, 2015, MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition, Cancer Lett., 364, 33, 10.1016\u002Fj.canlet.2015.04.023\nTejero, 2014, miR-141 and miR-200c as markers of overall survival in early stage non-small cell lung cancer adenocarcinoma, PLoS One, 9, 10.1371\u002Fjournal.pone.0101899\nTierney, 2007, Practical methods for incorporating summary time-to-event data into meta-analysis, Trials, 8, 16, 10.1186\u002F1745-6215-8-16\nToiyama, 2014, Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer, Ann. 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Biochem., 83, 1289, 10.1080\u002F09168451.2019.1606697\nZhang, 2015, MicroRNA-141 is a biomarker for progression of squamous cell carcinoma and adenocarcinoma of the lung: clinical analysis of 125 patients, Tohoku J. Exp. Med., 235, 161, 10.1620\u002Ftjem.235.161\nZhang, 2018, Exosome-mediated miR-200b promotes colorectal cancer proliferation upon TGF-beta1 exposure, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 1135, 10.1016\u002Fj.biopha.2018.07.042\nZhao, 2013, miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4, Mol. Cancer Ther., 12, 2569, 10.1158\u002F1535-7163.MCT-13-0296\nZhao, 2013, MiRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4, Mol. Cancer Ther., 12, 2569, 10.1158\u002F1535-7163.MCT-13-0296\nZhou, 2017, miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K\u002FAkt signaling pathway and inhibites cell migration via targeting ZEB1, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 85, 113, 10.1016\u002Fj.biopha.2016.11.100\nZhou, 2018, Dysregulation of miR-200s clusters as potential prognostic biomarkers in acute myeloid leukemia, J. Transl. Med., 16, 135, 10.1186\u002Fs12967-018-1494-7\nZhu, 2014, Expression of miR-29c, miR-93, and miR-429 as potential biomarkers for detection of early stage non-small lung cancer, PLoS One, 9, 10.1371\u002Fjournal.pone.0087780\nZhu, 2014, Prognostic significance of microRNA-141 expression and its tumor suppressor function in human pancreatic ductal adenocarcinoma, Mol. Cell. 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Medicine, 15, 542, 10.1016\u002F0891-5849(93)90453-2\nGómez-Díaz, 1996, Antioxidant ascorbate is stabilized by NADH-coenzyme Q10 reductase in plasma membrane, Journal of Bioenergetics and Biomembranes\nHockenbery, 1993, Bel-2 functions in an antioxidant pathway to prevent apoptosis, Cell, 75, 241, 10.1016\u002F0092-8674(93)80066-N\nIshizaki, 1995, Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells, Molecular Biology of the Cell, 6, 1443, 10.1091\u002Fmbc.6.11.1443\nKagan, 1996, Coenzyme Q: its role in scavenging and generation of radicals in membranes, 157\nKant, 1972, Cation-impermeable inside-out and right-side-out vesicles from human erythrocyte membranes, Nature, 240, 26\nKobayashi, 1991, Kinetic behavior of the monodedydroascorbate radical studied by pulse radiolysis, Biochemistry, 30, 8310, 10.1021\u002Fbi00098a005\nMinetti, 1992, Iron-induced ascorbate oxidation in plasma as monitored by ascorbate free radical formation, Biochemistry Journal, 282, 459, 10.1042\u002Fbj2820459\nNakamura, 1994, One- and two-electron reduction of quinones by rat liver subcellular fractions, Journal of Biochemistry, 115, 1141, 10.1093\u002Foxfordjournals.jbchem.a124470\nNavarro, 1995, A phospholipid-dependent NADH-coenzyme Q reductase from liver plasma membrane, Biochemistry and Biophysics Research Communication, 212, 138, 10.1006\u002Fbbrc.1995.1947\nNavas, 1990, Role of pyridine nucleotides in the control of cell growth, Vol. I, 225\nPethig, 1985, Enzyme-controlled scavenging of ascorbyl and 2,6-dimethoxysemiquinone free radicals in Ehrlich ascites tunor cells, 82, 1439\nRemacle, 1980, The binding of cytochrome b5 to plasma membranes of rat liver. 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2006, Aquaretic effect of lixivaptan, an oral, non-peptide, selective V2 receptor vasopressin antagonist, in New York Heart Association functional class II and III chronic heart failure patients, J. 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Physiol., 265, F461","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":740},"10.1007\u002Fs10440-022-00541-7",{"id":742,"text":743,"url":744,"identifiers":745},"04c8190d-7d14-4170-9d7e-bbdce7f00d1f","Asahina, 1995, Increased gene expression of water channel in cirrhotic rat kidneys, Hepatology, 21, 169, 10.1002\u002Fhep.1840210128","https:\u002F\u002Fjournals.lww.com\u002F01515467-199501000-00027",{"doi":746},"10.1002\u002Fhep.1840210128",{"id":748,"text":749,"url":750,"identifiers":751},"e84f3bbc-c051-4f21-97c6-eae443aaae7a","Asai, 2003, Pathogenesis of nephrogenic diabetes insipidus by aquaporin-2 C-terminus mutations, Kidney Int., 64, 2, 10.1046\u002Fj.1523-1755.2003.00049.x","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0085253815492865",{"doi":752},"10.1046\u002Fj.1523-1755.2003.00049.x",{"id":754,"text":755,"url":756,"identifiers":757},"5da00034-8c16-49cd-a0db-43d516892852","Babey, 2011, Familial forms of diabetes insipidus: clinical and molecular characteristics, Nat. Rev. Endocrinol., 7, 701, 10.1038\u002Fnrendo.2011.100","https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fnrendo.2011.100",{"doi":758},"10.1038\u002Fnrendo.2011.100",{"id":760,"text":761,"url":762,"identifiers":763},"1dbcc253-6635-4c4f-aa98-bf1fc219bff3","Bai, 1996, Structure of aquaporin-2 vasopressin water channel, J. Biol. Chem., 271, 5171, 10.1074\u002Fjbc.271.9.5171","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0021925818825650",{"doi":764},"10.1074\u002Fjbc.271.9.5171",{"id":18,"text":766,"url":767,"identifiers":768},"Barile, 2005, Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct, Mol. 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Invest., 106, 1115, 10.1172\u002FJCI9594","http:\u002F\u002Fwww.jci.org\u002Farticles\u002Fview\u002F9594",{"doi":785},"10.1172\u002Fjci9594",{"id":787,"text":788,"url":789,"identifiers":790},"32189a32-0d4b-4ac7-9433-674c9eaa5941","Bouley, 2006, Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in ‘endocytosis-resistant’ membrane domains after vasopressin treatment, Biol. Cell, 98, 215, 10.1042\u002FBC20040054","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1042\u002FBC20040054",{"doi":791},"10.1042\u002Fbc20040054",{"id":793,"text":794,"url":795,"identifiers":796},"176da654-efb7-4a1b-9bc7-b8642920d29b","Brown, 2008, Phosphorylation events and the modulation of aquaporin 2 cell surface expression, Curr. Opin. Nephrol. 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Nephrol., 16, 2872, 10.1681\u002FASN.2005010104","https:\u002F\u002Fdoi.org\u002F10.1681\u002Fasn.2005010104",{"mag":814,"openalex":815,"pm":816,"doi":817},"2117889729","W2117889729","16120822","10.1681\u002Fasn.2005010104",{"id":819,"text":820,"url":821,"identifiers":822},"100a5c03-3c2e-459d-abbc-50bfb9aa9da4","Deen, 1995, Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing, J. Clin. Invest., 95, 2291, 10.1172\u002FJCI117920","http:\u002F\u002Fwww.jci.org\u002Farticles\u002Fview\u002F117920",{"doi":823},"10.1172\u002Fjci117920",{"id":825,"text":826,"url":827,"identifiers":828},"73e7d3d3-aa5b-4dec-a164-d003ea6d9cdb","Deen, 1994, Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine, Science, 264, 92, 10.1126\u002Fscience.8140421","https:\u002F\u002Fwww.science.org\u002Fdoi\u002F10.1126\u002Fscience.8140421",{"doi":829},"10.1126\u002Fscience.8140421",{"id":18,"text":831,"url":832,"identifiers":833},"Denker, 1988, Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules, J. Biol. 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