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Cancer 67:1954–1959\nMcInnes JA, Knobf MT (2001) Weight gain and quality of life in women treated with adjuvant chemotherapy for early-stage breast cancer. Oncol Nurs Forum 28:675–684\nDemark-Wahnefried W, Peterson B, McBride C et al (2000) Current health behaviors and readiness to pursue life-style changes among men and women diagnosed with early stage prostate and breast carcinomas. Cancer 88:674–684\nLoprinzi CL, Athmann LM, O’Fallon J et al (1996) Randomized trial of dietician counseling to try to prevent weight gain associated with breast cancer adjuvant chemotherapy. Oncology 53:228–232\nThomson CA, Rock CL, Giuliano AR et al (2005) Longitudinal changes in body weight and body composition among women previously treated for breast cancer consuming a high-vegetable, fruit and fiber, low-fat diet. Eur J Nutr 44:18–25\nHebert JR, Ebbeling CB, Olendzki BC et al (2001) Change in women’s diet and body mass following intensive intervention for early-stage breast cancer. J Am Diet Assoc 101:421–431\nDansinger ML, Gleason JA, Griffith JL et al (2005) Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 293:43–53\nDe Waard F, Ramlau R, Mulders Y et al (1993) A feasibility study on weight reduction in obese postmenopausal breast cancer patients. Eur J Cancer Prev 2:233–238\nGoldstein DJ (1992) Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord 16:397–415\nPasanisi F, Contaldo F, De Simone G, Mancini M (2001) Benefits of sustained moderate weight loss in obesity. Nutr Metab Cardiovasc Dis 11:401–406\nNational Heart Lung and Blood Institute, National Institutes of Health (1998) Clinical guidelines on the identification, evaluation and treatment of overweight and obesity adults — the evidence report. Obes Res 6:51S–209S\nChlebowski RT, Blackburn GL, Thomson CA et al (2006) Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women’s Intervention Nutrition Study. J Natl Cancer Inst 98:1767–1776\nDalle Grave R, Calugi S, Molinari E et al; the QUOVADIS Study Group (2005) Weight loss expectations in obese patients and treatment attrition: an observational multicenter study. Obesity Res 13:1961–1969\n— (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP ATP-III) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486–2497\nSinagra D, Amato C, Scarpita AM et al (2002) Metabolic syndrome and breast cancer risk. Eur Rev Med Pharmacol Sci 6:55–59",{"EN":757},"Today breast cancer (BC) patients can expect more prolonged survival than in the past, but obesity at diagnosis and\u002For weight gain during adjuvant therapies increase the risk of recurrences as well as of weight-related disorders (diabetes, cardiovascular disease…). Therefore lifestyle intervention might offer a valuable approach to positively influence the prognosis of survivors. The charts of 189 overweight\u002Fobese outpatients with “early-stage BC” were reviewed to evaluate the effects of nutritional intervention on weight, body mass index (BMI), waist circumference and metabolic parameters. After the first clinical evaluation, in 97 subjects (education group), dieting therapy and periodical medical examinations were connected with brief individual sessions of nutritional education. Instead, 92 patients (no-education group) were treated only with diet and routine visits. At baseline and after nearly 1 year of treatment, data (weight, waist circumference, BMI, systolic and diastolic pressure, metabolic parameters and results of a battery of self-administered questionnaires to assess Nutritional Knowledge (NK), Physical Functioning (PF) and Quality Of Life (QOL) of patients) were collected and compared. Ninety-two (48.7%) patients completed a oneyear follow-up. The dropout rate was higher (73.2%) in traditionally treated women (no-education group) than in education group patients (22.8%); these data highlight that more educated patients completed the programme than non-educated patients (ODs 9.2, p \u003C 0.000). The low follow-up rate makes any comparison between the 2 types of treatment impossible since the weight and metabolic changes of the vast majority of the non-educated subjects remain unknown. Anyway, the education group patients, in active follow-up at 1 year, showed significant weight loss (−6.6 kg, SD 3.7) and improvements of metabolic parameters and questionnaire scores. Data from the study show the usefulness of this simple nutritional education intervention, which appears to increase the adherence to a weight loss programme. 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J Agric Food Chem 50:5870–5877",{"doi":1366},"10.1021\u002Fjf0256135",{"id":22,"text":1368,"url":22,"identifiers":1369},"Frankel S, Robinson GE, Berenbaum MR (1998) Antioxidant capacity and correlated characteristics of 14 unifloral honeys. J Apic Res 37:27–31",{"doi":1370},"10.1080\u002F00218839.1998.11100951",{"id":22,"text":1372,"url":22,"identifiers":1373},"Aljadi AM, Kamaruddin MY (2004) Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys. Food Chem 85:513–518",{"doi":1374},"10.1016\u002FS0308-8146(02)00596-4",{"id":22,"text":1376,"url":22,"identifiers":1377},"Inoue K, Murayarna S, Seshimo F et al (2005) Identification of phenolic compound in manuka honey as specific superoxide anion radical scavenger using electron spin resonance (ESR) and liquid chromatography with coulometric array detection. J Sci Food Agric 85:872–878",{"doi":1378},"10.1002\u002Fjsfa.1952",{"id":22,"text":1380,"url":22,"identifiers":1381},"Blasa M, Candiracci M, Accorsi A (2006) Raw Millefiori honey is packed full of antioxidants. Food Chem 97:217–222",{"doi":1382},"10.1016\u002Fj.foodchem.2005.03.039",{"id":22,"text":1384,"url":22,"identifiers":1385},"Nagai T, Inoue R, Kanamori N et al (2006) Characterization of honey from different floral sources. Its functional properties and effects of honey species on storage of meat. Food Chem 97:256–262",{"doi":1386},"10.1016\u002Fj.foodchem.2005.03.045",{"id":22,"text":1388,"url":22,"identifiers":1389},"Al-Waili NS (2003) Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. J Med Food 6:135–140",{"doi":1390},"10.1089\u002F109662003322233549",{"id":22,"text":1392,"url":22,"identifiers":1393},"Meda A, Lamien CE, Romito M et al (2005) Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem 91:571–577",{"doi":1394},"10.1016\u002Fj.foodchem.2004.10.006",{"id":22,"text":1396,"url":22,"identifiers":1397},"McKibben J, Engeseth NJ (2002) Honey as a protective agent against lipid oxidation in ground turkey. J. Agric Food Chem 50:592–595",{"doi":1398},"10.1021\u002Fjf010820a",{"id":22,"text":1372,"url":22,"identifiers":1400},{"doi":1374},{"id":22,"text":1402,"url":22,"identifiers":1403},"Bertoncelj J, Dobersěk U, Jamnik M, Golob T (2007) Evaluation of the phenolic content, antioxidant activity and colour of Slovenian honey. Food Chem 105:822–828",{"doi":1404},"10.1016\u002Fj.foodchem.2007.01.060",{"id":22,"text":1406,"url":22,"identifiers":1407},"Baltrušaitė V, Rimantas P, Čksterytė V (2007) Radical scavenging activity of different floral origin honey and beebread phenolic extracts. Food Chem 101:502–514",{"doi":1408},"10.1016\u002Fj.foodchem.2006.02.007",{"id":22,"text":1410,"url":22,"identifiers":1411},"Schramm DD, Karim M, Schrader HR et al (2003) Honey with high levels of antioxidants can provide protection to healthy human subjects. J Agric Food Chem 51:1732–1735",{"doi":1412},"10.1021\u002Fjf025928k",{"id":22,"text":1414,"url":22,"identifiers":1415},"Beretta G, Orioli M, Facino RM (2007) Antioxidant and radical scavenging activity of honey in endothelial cell culture (EA.hy926). Planta Med 73:1182–1189.",{"doi":1416},"10.1055\u002Fs-2007-981598",{"id":22,"text":1418,"url":22,"identifiers":1419},"Molan PC (2001) Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2:9–13",{"doi":1420},"10.2165\u002F00128071-200102010-00003",{"id":22,"text":1422,"url":22,"identifiers":1423},"Hamzaoglu I, Saribeyoglu K, Durak H et al (2000) Protective covering of surgical wounds with honey impedes tumor implantation. Arch Surg 135–142",{"doi":1424},"10.1001\u002Farchsurg.135.12.1414",{"id":22,"text":1426,"url":22,"identifiers":1427},"Mobarok Ali ATM, Al-Swayeh AO (1997) Natural honey prevents ethanol.induced increased vascular permeability changes in the rat stomach. J Ethnopharmacol 55:231–239",{"doi":1428},"10.1016\u002FS0378-8741(96)01504-8",{"id":22,"text":1430,"url":22,"identifiers":1431},"Bang LM, Buntting C, Molan P (2003) The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Altern Compl Med 9:267–273",{"doi":1432},"10.1089\u002F10755530360623383",{"id":22,"text":1434,"url":22,"identifiers":1435},"Lopez-Lazaro M (2006) Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. Cancer Lett 252:1–8",{"doi":1436},"10.1016\u002Fj.canlet.2006.10.029",{"id":22,"text":1438,"url":22,"identifiers":1439},"Facino RM (2001) Honey in tumor surgery. Arch Surg 136:600",{"doi":1440},"10.1001\u002Farchsurg.136.5.600",{"id":22,"text":1442,"url":22,"identifiers":1443},"Michaluart P, Masferrer JL, Carothers AM et al (1999) Inhibitory effects of caffeic acid phenethyl esther on the activity and expression of cyclooxygenase-2 in human oral epithelial cell and in rat model of inflammation. Cancer Res 59:2347–2352",{},{"id":22,"text":1445,"url":22,"identifiers":1446},"Greten FR, Eckmann L, Greten TF et al (2004) IKK links inflammation and tumorigenesis in mouse model of colitis associated cancer. Cell 118:285–296",{"doi":1447},"10.1016\u002Fj.cell.2004.07.013",{"id":22,"text":1449,"url":22,"identifiers":1450},"Wang XH, Andrae L, Engeseth NJ (2002) Antimutagenic effect of various honeys and sugars against Trp-p-1. J Agric Food Chem 50:6923–6928",{"doi":1451},"10.1021\u002Fjf025641n",{"id":22,"text":1453,"url":22,"identifiers":1454},"Orsolic N, Basic I (2004) Honey as a cancer-preventive agent. Periodicum Biolog 106:397–401",{},{"id":22,"text":1456,"url":22,"identifiers":1457},"Swellam T, Miyanaga N, Onozawa M et al (2003) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. Int J Urol 10:213–219",{"doi":1458},"10.1046\u002Fj.0919-8172.2003.00602.x",{"id":22,"text":1460,"url":22,"identifiers":1461},"Al-Waili NS, Boni NS (2003) Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food 6:129–133",{"doi":1462},"10.1089\u002F109662003322233530",{"id":22,"text":1464,"url":22,"identifiers":1465},"Bilsel Y, Bugra D, Yamaner S et al (2002) Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Dig Surg 19:306–311",{"doi":1466},"10.1159\u002F000064580",{"id":22,"text":1468,"url":22,"identifiers":1469},"Jeddar A, Kharsany A, Ramsaroop UG et al (1985) The antibacterial action of honey: an in vitro study. S Afr Med J 67:257–258",{},{"id":22,"text":1471,"url":22,"identifiers":1472},"Osato MS, Reddy SG, Graham DY (1999) Osmotic effect of honey on growth and viability of Helicobacter pylori. Dig Dis Sci 44:462–464",{"doi":1473},"10.1023\u002FA:1026676517213",{"id":22,"text":1475,"url":22,"identifiers":1476},"Ali AT, Chowdhury MN, Al-Humayyd MS (1999) Inhibitory effect of natural honey on Helicobacter pylori. Tropical Gastroenterol 12:139–143",{},{"id":22,"text":1478,"url":22,"identifiers":1479},"Salem SN (1981) Treatment of gastroenteritis by the use of honey. Islam Med 1:358–362",{},{"id":22,"text":1481,"url":22,"identifiers":1482},"Haffejee IE, Moosa A (1985) Honey in the treatment of infantile gastroenteritis. Br Med J 290:1866–1867",{"doi":1483},"10.1136\u002Fbmj.290.6485.1866",{"id":22,"text":1485,"url":22,"identifiers":1486},"World Health Organisation (1976) Treatment and prevention of dehydration in diarrhoeal diseases. A guide for use at the primary level. WHO, Geneva, pp 1–13",{},{"id":22,"text":1488,"url":22,"identifiers":1489},"Chatterjee A, Mahalanabis D, Jalan KN (1978) Oral rehydration in infantile diarrhea. Controlled trial of a low sodium glucose electrolyte solution. Arch Dis Child 53:284–289",{"doi":1490},"10.1136\u002Fadc.53.4.284",{"id":22,"text":1492,"url":22,"identifiers":1493},"Sanz ML, Polemis N, Morales V et al (2005) In vitro investigation into the potential prebiotic activity of honey oligosaccharides. J Agric Food Chem 53:2914–2921",{"doi":1494},"10.1021\u002Fjf0500684",{"id":22,"text":1496,"url":22,"identifiers":1497},"Yun YW (1996) Fructooligosaccharides: occurrence, preparation and application. Enzyme Microb Technol 19:107–117",{"doi":1498},"10.1016\u002F0141-0229(95)00188-3",{"id":22,"text":1500,"url":22,"identifiers":1501},"Kajiwara S, Gandhi H, Ustunol Z (2002) Effect of honey on the growth of and acid production by human intestinal Bifidobacterium spp: an in vitro comparison with commercial oligosaccharides and inulin. 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Adv Clin Chem 24:217–298\nAssmann G, Nofer JR (2003) Atheroprotective effects of high density lipoproteins. Annu Rev Med 54:321–341\nQiao Q, Gao W, Zhang L et al (2007) Metabolic syndrome and cardiovascular disease. Ann Clin Biochem 44:232–263\nFerretti G, Bacchetti T, Busni D et al (2004) Protective effect of paraoxonase activity in high-density lipoproteins against erythrocyte membranes peroxidation: a comparison between healthy subjects and type 1 diabetic patients. J Clin Endocrinol Metab 89:2957–2962\nQuijada Z, Paoli M, Zerpa Y et al (2008) The triglyceride\u002FHDL-cholesterol ratio as a marker of cardiovascular risk in obese children; association with traditional and emergent risk factors. Pediatr Diabetes 9:464–471\nGenest J, McNamara J, Salem D, Schaefer E (1991) Prevalence of risk factors in men with premature coronary artery disease. Am J Cardiol 67:1185–1189\nNegre-Salvayre A, Dousset N, Ferretti G et al (2006) Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells. Free Radic Biol Med 41:1031–1040\nNavab M, Yu R, Gharavi N et al (2007) High-density lipoprotein: antioxidant and anti-inflammatory properties. Curr Atheroscler Rep 9:244–248\nYoshikawa M, Sakuma N, Hibino T et al (1997) HDL3 exerts more powerful anti-oxidative, protective effects against copper-catalyzed LDL oxidation than HDL2. Clin Biochem 30:221–225\nKlimov AN, Gurevich VS, Nikiforova AA et al (1993) Antioxidative activity of high density lipoproteins in vivo. Atherosclerosis 100:13–18\nMackness MI, Arrol S, Abbott C, Durrington PN (1993) Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis 104:129–135\nMackness MI, Durrington PN (1995) HDL, its enzymes and its potential to influence lipid peroxidation. Atherosclerosis 115:243–253\nWatson AD, Berliner JA, Hama SY et al (1995) Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Invest 96:2882–2891\nAviram M, Rosenblat M (2005) Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences. Curr Opin Lipidol 16:393–399\nFerretti G, Bacchetti T, Moroni C et al (2005) Paraoxonase activity in high-density lipoproteins: a comparison between healthy and obese females. J Clin Endocrinol Metab 90:1728–1733\nMackness MI, Harty D, Bhatnagar D et al (1991) Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus. Atherosclerosis 86:193–199\nFerretti G, Bacchetti T, Masciangelo S, Pallotta G (2008) Lipid peroxidation in hemodialysis patients: effect of vitamin C supplementation. Clin Biochem 41:381–386\nAyub A, Mackness MI, Arrol S et al (1999) Serum paraoxonase after myocardial infarction. Arterioscler Thromb Vasc Biol 19:330–335\nFerretti G, Bacchetti T, Principi F et al (2005) Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity. Mult Scler 11:677–682\nShih DM, Gu L, Xia YR et al (1998) Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 394:284–287\nTward A, Xia YR, Wang XP et al (2002) Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation 106:484–490\nvan Himbergen TM, van der Schouw YT, Voorbij HA et al (2008) Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch women. Atherosclerosis 199:408–414\nSentürk T, Sarandöl E, Güllülü S et al (2008) Association between paraoxonase 1 activity and severity of coronary artery disease in patients with acute coronary syndromes. Acta Cardiol 63:361–367\nKlimov AN, Kozhevnikova KA, Kuzmin AA et al (2001) On the ability of high density lipoproteins to remove phospholipid peroxidation products from erythrocyte membranes. Biochemistry (Mosc) 66:300–304\nFerretti G, Bacchetti T, Moroni C et al (2003) Copper-induced oxidative damage on astrocytes: protective effect exerted by human high density lipoproteins. Biochim Biophys Acta 1635:48–54\nRosenblat M, Vaya J, Shih D, Aviram M (2005) Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine. Atherosclerosis 179:69–77\nEfrat M, Aviram M (2008) Macrophage paraoxonase 1 (PON1) binding sites. Biochem Biophys Res Commun 376:105–110\nBowry VW, Stanley KK, Stocker R (2002) High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors. Proc Natl Acad Sci U S A 89:10316–10320\nJakubowski H (2000) Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation. J Biol Chem 275:3957–3962\nJakubowski H (2002) Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease. J Biol Chem 277:30425–30428\nFerretti G, Bacchetti T, Moroni C et al (2004) Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells. J Cell Biochem 92:351–360",{"EN":1521},"High-density lipoproteins (HDL) plasma levels are inversely correlated with the risk of atherosclerosis and coronary heart disease. The protective effect of HDL has been related to their role in the cholesterol reverse transport and to their ability to inhibit oxidation of low-density lipoproteins (LDL). Several lines of evidence suggest that the protective effect of HDL is at least partially related to the enzyme paraoxonase (PON1), a calcium-dependent esterase associated with the HDL surface. It has been hypothesised that PON1 may have two independent antiatherogenic roles: (a) by preventing the accumulation of oxidised lipids from oxidised lipoproteins (LDL and HDL) and thereby inhibiting the atherogenic and inflammatory response induced by lipid peroxidation products; (b) by detoxifying homocysteine thiolactone (HTL), a toxic metabolite of homocysteine. Recently, it has been reported that HDL-associated PON1 could also play a regulatory role in HDL binding to cell membranes and in HDL-mediated cholesterol efflux in macrophages. 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MSc Thesis, Food Technology Department Faculty of Agriculture, Suez Canal University, Ismailia, Egypt\nProdanov M, Sierra I, Vidal-Valverde C (2004) Influence of soaking and cooking on the thiamin, riboflavin and niacin contents of legumes. Food Chem 84:271–277\nKhatoon N, Prakash J (2006) Nutrient retention in microwave cooked germinated legumes. Food Chem 97:115–121\nVidal-Valverde C, Sierra I, Frias J et al (2002) Nutritional evaluation of lentil flours obtained after short-time soaking process. Eur Food Res Technol 215:138–144\nKhan MA, Ghafoor A (1978) The effect of soaking, germination and cooking on the protein quality of mash beans (Phaseolus mungo). J Sci Food Agric 29:461–464\nSharma J (2006) Effect of processing methods on the quality of cereal and legume products. PhD Thesis, Centre for Rural Development & Technology, Indian Institute of Technology Delhi, New Delhi, India\nSangronis E, Machado CJ (2007) Influence of germination on the nutritional quality of Phaseolus vulgaris and Cajanus cajan. LWT Food Sci Technol 40:116–120\nEl-Adawy TA (2002) Nutritional composition and antinutritional factors of chickpeas (Cicer arietinum L.) undergoing different cooking methods and germination. Plant Foods Hum Nutr 57:83–97\nJood S, Chauhan BM, Kapoor AC (1988) Contents and digestibility of carbohydrates of chickpea and black gram as affected by domestic processing and cooking. Food Chem 30:113–127\nRehinan Z, Rashid M, Shah WH (2004) Insoluble dietary fibre components of food legumes as affected by soaking and cooking processes. Food Chem 85:245–249\nSomogyi M (1952) A new method for the estimation of sugars. J Biol Chem 200:245\nHedge JE, Hofreiter BT (1962) In: Whistler RL, Be Miller JN (eds) Carbohydrate chemistry 17. Academic Press, New York\nZhang Z-W, Watanabe T, Shimbo S et al (1998) Lead and cadmium contents in cereals and pulses in north-eastern China. Sci Total Environ 220:137–145\nBennett JP, Chiriboga E, Coleman J, Waller DM (2000) Heavy metals in wild rice from northern Wisconsin. Sci Total Environ 246:261–269\nRoche Vitamins & Fine Chemicals Division (1995). Analytical methods for vitamins in food\u002Fpharma premixes. F. Hoffmann-La Roche Ltd., CH-4002 Basel, Switzerland, pp 17–20\nAOAC (1990) Official methods of analysis of the association of official analytical chemist, 15th edn. AOAC, Washington, DC\nSilva HC, Braga G (1982) Effect of soaking on the oligosaccharides content of dry beans (Phaseolus vulgaris). J Food Sci 47:924–929\nLee CK, Karunanaithy R (1990) Effects of germination on the chemical composition of Glycine and Phaseolus beans. J Sci Food Agric 51:437–445\nBau H, Villaume C, Nicolas J, Mejean L (1997) Effect of germination on chemical composition, biochemical constituents and antinutritional factors of soya bean (Glycine max) seeds. J Sci Food Agric 73:1–9\nKumar KG, Venkataraman LV (1976) Studies on the in vitro digestibility of starch in some legumes before and after germination. Nutr Rep Int 13:115–120\nMostafa MM, Rahma EH (1987) Chemical and nutritional changes in soybean during germination. Food Chem 23:257–275\nChandrasiri V, Bau HM, Villaume C et al (1987) Effect de la germination de la graine de soja sur la composition et la valeur nutritionnelle de sa farine. Sciences des Aliments 7 (thers seric):139–150\nFordham JR, Wells GE, Chan LH (1975) Sprouting of seeds and nutrient composition of seeds and sprouts. J Food Sci 40:552–556\nOsborn TW (1977) Elemental composition of soybean meal and interlaboratory performance. J Agric Food Chem 25:229–232\nBau HM, Debry G (1979) Germinated soybean protein products: chemical and nutritional evaluation. J Am Oil Chem Soc 56:160–162\nTrugo L, Donangelo N, Trugo M, Bach K (2000) Effect of heat treatment on nutritional quality of germinated legume seeds. J Agric Food Chem 48:2082–2086\nAugustin J, Klein B (1989) Nutrient composition of raw, cooked, canned and sprouted legumes. In: Legumes, chemistry, technology and human nutrition. Marcel Dekker, New York, pp 187–217\nAlexander JC (1983) Sprouts in our muffins: nutrient content and quality of germinated cereals. Ontario Ministry Agric Food Canada (Highlights) 6:1–3\nRahman AHYA (1984) Improvement of nutritive value in corn for human nutrition. Food Chem 13:17–23\nSattar A, Durrani SK, Mahmood F et al (1989) Effect of soaking and germination temperatures on selected nutrients and antinutrients of mungbean. Food Chem 34:111–120\nNnanna IA, Phillips RD (1989) Amino acid composition protein quality and water-soluble vitamin content of germinated cowpeas (Vigna unguiculata). Plant Foods Hum Nutr 39:187–200\nKhalil AH, Mansour EH (1995) The effect of cooking, autoclaving and germination on the nutritional quality of faba beans. Food Chem 54:177–182\nAhmad S, Pathak DK (2000) Nutritional changes in soybean during germination. J Food Sci Technol 37:665–666\nXu M-J, Dong J-F, Zhu M-Y (2005) Effects of germination conditions on ascorbic acid level and yield of soybean sprouts. J Sci Food Agric 85:943–947\nWang N, Hatcher DW, Toews R, Gawalko EJ (2009) Influence of cooking and dehulling on nutritional composition of several varieties of lentils (Lens culinaris). LWT Food Sci Technol 42:842–848\nEl-Tinay AH, Mahgoub SO, Mohamed BE, Hamad MA (1989) Proximate composition and mineral and phytate contents of legumes grown in Sudan. J Food Compos Anal 2:69–78\nHaytowitz DB, Matthews RH (1983) Effect of cooking on nutritive retention of legumes. Cereal Food World 28:326–364\nLonge OG (1983) Varietal differences in chemical characteristics related to cooking quality of cowpea. J Food Process Pres 7:143–150\nSalama AM, Ragab GH (1997) Composition of conventional and microwave cooking of kidney beans and carrot in relation to chemical composition, nutritive value and sensory characteristics. J Home Econ - Menoufia Uni 7:213–225\nUherova R, Hozova B, Smirnov V (1993) The effect of microwave heating on retention of some B-vitamins. Food Chem 46:293–295\nSood M, Malhotra SR (2001) Effects of processing and cooking on ascorbic acid content of chickpea (Cicer arietinum L) varieties. J Sci Food Agric 82:65–68",{"EN":1623},"Food legumes are widely consumed all over the world as these are good sources of dietary proteins, carbohydrates and minerals. Common domestic processing techniques like soaking, germination and cooking enhance the digestibility and nutritive value of legumes. The effects of soaking, germination (1, 2 and 3 day) and cooking (microwave, pressure and ordinary cooking) were studied on the carbohydrates, crude protein, mineral and vitamin content of soybean. Germination (2nd day) leads to significant increases in the sugar, crude protein, Ca, Cu, Mn, Zn, riboflavin, niacin and ascorbic acid content. Microwave cooking resulted in greater retention of minerals and vitamins as compared to pressure cooking and ordinary cooking. Based on the results, germination (day 2) for soybean should be popularised as a simple process for naturally fortifying food with essential minerals and vitamins. While amongst cooking methods, microwave cooking could be suggested for soybean preparation.",{"EN":1625},"Effect of domestic processing techniques on the nutritional quality of the soybean",{"VOID":1627},"10.1007\u002Fs12349-009-0079-7","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12349-009-0079-7",[1630,1645,1657],{"id":1631,"sortIndex":176,"researcher":22,"roles":1632,"affiliations":1633,"properties":1642},"d340f8d9-5677-4487-8576-7ebb2118792a",[767],[1634],{"id":22,"sortIndex":23,"affiliation":1635,"properties":22},{"id":1636,"createTime":1637,"updateTime":1637,"relativeEntities":1638,"slug":22,"properties":1639,"entityType":59,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"3b604384-2fab-4fe7-a2cb-75247d17afbf","2024-01-16T03:01:42.872+00:00",[],{"title":1640},{"VI":1641},"Centre for Rural Development & Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India",{"title":1643},{"VI":1644},"S.N. Naik",{"id":1646,"sortIndex":156,"researcher":22,"roles":1647,"affiliations":1648,"properties":1654},"4da103c3-7a21-455b-8fd8-83102692db71",[767],[1649],{"id":22,"sortIndex":23,"affiliation":1650,"properties":22},{"id":1636,"createTime":1637,"updateTime":1637,"relativeEntities":1651,"slug":22,"properties":1652,"entityType":59,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1653},{"VI":1641},{"title":1655},{"VI":1656},"Santosh Satya",{"id":1658,"sortIndex":23,"researcher":22,"roles":1659,"affiliations":1660,"properties":1666},"b13351da-4877-439b-a994-10dbd1818301",[767],[1661],{"id":22,"sortIndex":23,"affiliation":1662,"properties":22},{"id":1636,"createTime":1637,"updateTime":1637,"relativeEntities":1663,"slug":22,"properties":1664,"entityType":59,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1665},{"VI":1641},{"title":1667},{"VI":1668},"Geetanjali Kaushik",{"url":1628,"publisher":1670,"properties":1699},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1671,"slug":10,"properties":1672,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1677,"manageAffiliations":1678,"indexDatabases":1679,"url":22,"thumbnailPath":22,"statistic":1694,"gsStatistic":22,"type":125,"analyzePriority":22},[],{"issn":1673,"eissn":1674,"title":1675,"url":1676},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1680,1687],{"id":74,"indexDatabase":1681,"url":89,"indexYears":22,"academicFieldIds":1686,"indexDatabaseRanking":22},{"id":76,"createTime":77,"updateTime":78,"relativeEntities":1682,"label":1683,"description":1684,"key":85,"publicationTags":1685,"standard":22},[],{"EN":81,"VI":81},{"VI":83,"EN":84},[87,88],[91],{"id":93,"indexDatabase":1688,"url":106,"indexYears":107,"academicFieldIds":1693,"indexDatabaseRanking":112},{"id":95,"createTime":96,"updateTime":97,"relativeEntities":1689,"label":1690,"description":1691,"key":103,"publicationTags":1692,"standard":22},[],{"EN":100,"VI":100},{"EN":100,"VI":102},[105],[109,110,111],{"impactFactor":23,"impactFactorByYear":1695,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":115,"totalPublicationByYear":1696,"totalCitation":23,"totalCitationByYear":1697,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":1698,"hindexLast5Year":23,"hindex":23},{},{"2008":117,"2009":118,"2010":119,"2011":120,"2012":121,"2013":122},{},{},{"volume":1700,"pages":1701},{"VOID":603},{"VOID":1702},"39-46","2010-02-04",{"id":1705,"createTime":1706,"updateTime":1707,"relativeEntities":1708,"slug":1709,"properties":1710,"entityType":147,"verifyStatus":148,"verifyTime":1723,"verifyNote":149,"syncStatus":21,"languages":22,"translateLanguages":1724,"viewCount":23,"primaryUrl":1726,"fullTextUrl":22,"authors":1727,"publicationType":217,"publisherRelationship":1822,"citationCount":22,"citationInfo":22,"publishDate":1857,"publishYear":1858,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":366},"911ab964-dcae-4ab4-a870-993bb56a8571","2024-01-21T16:00:01.066+00:00","2025-02-11T22:36:29.166+00:00",[],"Food-craving-is-associated-with-multiple-weight-loss-attempts",{"references":1711,"abstract":1713,"title":1716,"doi":1719,"keywords":1721},{"VOID":1712},"Eckardt K, Taube A, Eckel J (2011) Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity. Rev Endocr Metab Disord 12:163–172\nWing RR, Hill JO (2001) Successful weight loss maintenance. Annu Rev Nutr 21:323–341\nKarhunen L, Lyly M, Lapvetelainen A, Kolehmainen M, Laaksonen DE, Lahteenmaki L, Poutanen K (2012) Psychobehavioural factors are more strongly associated with successful weight management than predetermined satiety effect or other characteristics of diet. J Obes 2012:274068\nWang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W, Netusil N, Fowler JS (2001) Brain dopamine and obesity. Lancet 357:354–357\nStice E, Yokum S, Blum K, Bohon C (2010) Weight gain is associated with reduced striatal response to palatable food. J Neurosci 30:13105–13109\nVolkow ND, Wang GJ, Fowler JS, Tomasi D, Baler R (2011) Food and drug reward: overlapping circuits in human obesity and addiction. Curr Top Behav Neurosci 11:1–24\nWhite MA, Whisenhunt BL, Williamson DA, Greenway FL, Netemeyer RG (2002) Development and validation of the food-craving inventory. Obes Res 10:107–114\nvon Deneen KM, Liu Y (2011) Obesity as an addiction: why do the obese eat more? Maturitas 68:342–345\nVolkow ND, Wise RA (2005) How can drug addiction help us understand obesity? Nat Neurosci 8:555–560\nGearhardt AN, Yokum S, Orr PT, Stice E, Corbin WR, Brownell KD (2011) Neural correlates of food addiction. Arch Gen Psychiatry 68:808–816\nGreen MW, Rogers PJ, Elliman NA (2000) Dietary restraint and addictive behaviors: the generalizability of Tiffany’s cue reactivity model. Int J Eat Disord 27:419–427\nBlum K, Braverman ER, Holder JM, Lubar JF, Monastra VJ, Miller D, Lubar JO, Chen TJ, Comings DE (2000) Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoactive Drugs 32(Suppl: i–iv):1–112\nFranz MJ, VanWormer JJ, Crain AL, Boucher JL, Histon T, Caplan W, Bowman JD, Pronk NP (2007) Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. J Am Diet Assoc 107:1755–1767\nSvetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, Vollmer WM, Gullion CM, Funk K, Smith P, Samuel-Hodge C, Myers V, Lien LF, Laferriere D, Kennedy B, Jerome GJ, Heinith F, Harsha DW, Evans P, Erlinger TP, Dalcin AT, Coughlin J, Charleston J, Champagne CM, Bauck A, Ard JD, Aicher K (2008) Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA 299:1139–1148\nElfhag K, Rossner S (2005) Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain. Obes Rev 6:67–85\nOdom J, Zalesin KC, Washington TL, Miller WW, Hakmeh B, Zaremba DL, Altattan M, Balasubramaniam M, Gibbs DS, Krause KR, Chengelis DL, Franklin BA, McCullough PA (2010) Behavioral predictors of weight regain after bariatric surgery. Obes Surg 20:349–356\nJakicic JM (2009) The effect of physical activity on body weight. Obesity 17(Suppl 3):S34–S38\nPepino MY, Finkbeiner S, Mennella JA (2009) Similarities in food cravings and mood states between obese women and women who smoke tobacco. Obesity 17:1158–1163\nFabbricatore M, Imperatori C, Morgia A, Contardi A, Tamburello S, Tamburello A, Innamorati M (2011) Food craving and personality dimensions in overweight and obese patients attending low energy diet therapy. Obe Metab 7:e28–e34\nMoreno S, Rodriguez S, Fernandez MC, Tamez J, Cepeda-Benito A (2008) Clinical validation of the trait and state versions of the Food Craving Questionnaire. Assessment 15:375–387\nWhite MA, Grilo CM (2005) Psychometric properties of the Food Craving Inventory among obese patients with binge eating disorder. Eat Behav 6:239–245\nFabbricatore M, Imperatori C, Pecchioli C, Micarelli T, Contardi A, Tamburello S, Innamorati M, Tamburello A (2011) Binge eating and BIS\u002FBAS activity in obese patients with intense food craving who attend weight control programs. Obe Metab 7:e21–e27\nJarosz PA, Dobal MT, Wilson FL, Schram CA (2007) Disordered eating and food cravings among urban obese African American women. Eat Behav 8:374–381\nVander Wal JS, Johnston KA, Dhurandhar NV (2007) Psychometric properties of the State and Trait Food Cravings Questionnaires among overweight and obese persons. Eat Behav 8:211–223\nWing RR, Phelan S (2005) Long-term weight loss maintenance. Am J Clin Nutr 82:222S–225S\nCepeda-Benito A, Gleaves DH, Fernandez MC, Vila J, Williams TL, Reynoso J (2000) The development and validation of Spanish versions of the State and Trait Food Cravings Questionnaires. Behav Res Ther 38:1125–1138\nCepeda-Benito A, Fernandez MC, Moreno S (2003) Relationship of gender and eating disorder symptoms to reported cravings for food: construct validation of state and trait craving questionnaires in Spanish. Appetite 40:47–54\nMarlatt GA, Gordon JR (1985) Relapse prevention: maintenance strategies in the treatment of addictive behaviors. Guilford Press, New York\nKaplan GB, Heinrichs SC, Carey RJ (2011) Treatment of addiction and anxiety using extinction approaches: neural mechanisms and their treatment implications. Pharmacol Biochem Behav 97:619–625\nWise RA (2009) Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction. Trends Neurosci 32:517–524\nHogarth L (2011) The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity. Psychopharmacology 215:567–580\nPenas-Lledo EM, Loeb KL, Martin L, Fan J (2007) Anterior cingulate activity in bulimia nervosa: a fMRI case study. Eat Weight Disord 12:e78–e82\nMathes WF, Brownley KA, Mo X, Bulik CM (2009) The biology of binge eating. Appetite 52:545–553\nVolkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F (2011) Quantification of behavior sackler colloquium: addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci USA 108:15037–15042\nCoelho JS, Polivy J, Herman CP (2006) Selective carbohydrate or protein restriction: effects on subsequent food intake and cravings. Appetite 47:352–360\nMartin CK, O’Neil PM, Tollefson G, Greenway FL, White MA (2008) The association between food cravings and consumption of specific foods in a laboratory taste test. Appetite 51:324–326\nMeule A, Lutz A, Vogele C, Kubler A (2012) Food cravings discriminate differentially between successful and unsuccessful dieters and non-dieters. Validation of the Food Cravings Questionnaires in German. Appetite 58:88–97\nBudak AR, Thomas SE (2009) Food craving as a predictor of “relapse” in the bariatric surgery population: a review with suggestions. Bariatric Nursing and Surgical Patient Care 4:115–121\nGoldman RL, Borckardt JJ, Frohman HA, O’Neil PM, Madan A, Campbell LK, Budak A, George MS (2011) Prefrontal cortex transcranial direct current stimulation (tDCS) temporarily reduces food cravings and increases the self-reported ability to resist food in adults with frequent food craving. Appetite 56:741–746\nAlberts HJ, Mulkens S, Smeets M, Thewissen R (2010) Coping with food cravings. Investigating the potential of a mindfulness-based intervention. Appetite 55:160–163",{"EN":1714,"VI":1715},"The aim of the study was to investigate the association between food craving and lifetime number of weight-loss attempts, as a proxy index of difficulties in weight-loss maintenance. The participants were 100 adult out-patients with BMI ≥ 25 admitted at three medical centers for the treatment of obesity and excess weight in Rome (Italy). The patients were administered the State and Trait Food Cravings Questionnaire, trait version (FCQ-T). The patients with five or more weight loss episodes (compared to those with four treatments or less) differed in all the dimensions of the FCQ-T. Food craving is associated with more difficulties in weight-loss maintenance after weight-loss interventions.","Mục tiêu của nghiên cứu này là điều tra mối liên hệ giữa cảm giác thèm ăn và số lần cố gắng giảm cân trong suốt cuộc đời, như một chỉ số thay thế cho những khó khăn trong việc duy trì cân nặng sau khi giảm. Các tham gia nghiên cứu gồm 100 bệnh nhân ngoại trú từ 25 tuổi trở lên với chỉ số khối cơ thể (BMI) ≥ 25, được nhập viện tại ba trung tâm y tế để điều trị béo phì và thừa cân ở Rome (Ý). Những bệnh nhân này được yêu cầu điền vào Bảng hỏi Cảm giác Thèm ăn Đặc điểm và Tình trạng (FCQ-T). Những bệnh nhân đã có năm lần hoặc nhiều hơn trong các đợt giảm cân (so với những bệnh nhân có bốn đợt điều trị hoặc ít hơn) đã có sự khác biệt ở tất cả các khía cạnh của FCQ-T. Cảm giác thèm ăn có liên quan đến những khó khăn hơn trong việc duy trì giảm cân sau các can thiệp giảm cân.",{"EN":1717,"VI":1718},"Food craving is associated with multiple weight loss attempts","Cảm giác thèm ăn liên quan đến nhiều lần cố gắng giảm cân",{"VOID":1720},"10.1007\u002Fs12349-012-0115-x",{"VI":1722},"cảm giác thèm ăn, giảm cân, duy trì cân nặng, nghiên cứu y học","2025-02-05T18:33:19.947+00:00",[1725],"VI","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12349-012-0115-x",[1728,1753,1765,1784,1803],{"id":1729,"sortIndex":494,"researcher":22,"roles":1730,"affiliations":1731,"properties":1750},"c9220a66-5be5-4c47-8357-80ddcd19d1fd",[767],[1732,1742],{"id":1733,"sortIndex":156,"affiliation":1734,"properties":1741},"d8f5775c-9168-4e9b-939b-5c7990ca43a0",{"id":1735,"createTime":1736,"updateTime":1736,"relativeEntities":1737,"slug":22,"properties":1738,"entityType":59,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"68ba0723-ff63-436c-9a9d-cc1b82af0b17","2024-01-21T14:40:33.376+00:00",[],{"title":1739},{"VI":1740},"Istituto Skinner, Rome\u002FNaples, 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PL (1985) Proprietès physico-chimiques nutritionalles et chimiques (physico-chemical properties). In: Luquet FM (ed) Laits et produits latieres. Vache. Brevis. Chevre. [Milk and milk products from cows, sheeps and goats]. Apria, Paris, pp 349–367\nPark YW (1994) Hypo-allergenic and therapeutic significance of goat milk. Small Rumin Res 14:151–161\nScolozzi C, Martini M, Abramo F (2003) A method for identification and characterization of ewe’s milk fat globules. Milchwissensch 58:490–493\nHaenlein GFW (1996) Nutritional value of dairy products of ewe and goat milk. In: Anifantakis EM (ed) Proceedings of the IDF\u002FCIRVAL Seminar on the Production, Utilization of Ewe, Goat, Milk. International Diary Federation, Brussels, 9603, pp 159–179\nHaenlein GFW (2001) Past, present and future perspectives of small ruminant research. J Dairy Sci 84:2097–2115\nHaenlein GFW (2004) Goat milk in human nutrition. Small Rum Res 9:27–36\nBoza J, Sanz Sampelayo MR (1997) Aspectos nutricionales de la leche de chabra [Nutritional aspects of goat milk]. Ann Acad Cienc Vet Andalucìa Oriental 10:109–139\nSehat N, Rickert R, Massoba MM et al (1999) Improved separation of conjugated fatty acid methyl esters by silver ion-high-performance liquid chromatography. Lipids 34:407–413\nCabiddu A, Decandia M, Addis M et al (2005) Managing mediterranean pastures in order to enhance the level of beneficial fatty acids in sheep milk. Small Rum Res 59:169–180\nSanz Sampelayo MR, Chilliard Y, Schmidely CH, Boza J (2007) Influence of type of diet on the fat constituents of goat and sheep milk. Small Rum Res 68:42–63\nAOAC (1999) Official methods of analysis, 16th Edn. Association of Official Analytical Chemists, Gaithersburg, MD\nKonings AWT (1984) Lipid peroxidation in liposomes. In: Gregoriadis G (ed.) Liposomes technology. CRC Press, Boca Raton, FL, pp 139–161\nFolch J, Less M, Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:466–468\nSearcy RL, Bergquist LM (1960) A new color reaction for the quantitation of serum cholesterol. Clin Chim Acta 5:192–199\nMorand-Fehr P, Fedele V, Decandia M, Le Frileux Y (2007) Influence of farming and feeding systems on composition and quality of goat and sheep milk. Small Rum Res 68:20–34\nLoor JJ, Herbein JH (1998) Exogenous conjugated linoleic acid isomers reduce bovine milk fat concentration and yield by inhibiting de novo fatty acid synthesis. J Nutr 128:2411–2419\nKriss-Etherton PM (1999) Monounsaturated fatty acids and risk of cardiovascular disease. Circulation 100:1253–1258\nMcGuire MA, McGuire MK (2000) Conjugated linoleic acid (CLA): a ruminant fatty acid with benefical effects on human health. J Anim Sci 77:1–8\nPariza MW, Park Y, Cook ME (2001) The biologically active isomers of conjugated linoleic acid. Progr Lipid Res 40:283–298\nRiserus W, Vessby B, Arnlov J, Basw S (2004) Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory marker in obese man. Am J Clin Nutr 80:279–283\nNagao K, Yanagita T (2005) Conjugated fatty acids in food and their health benefits. J Biosci Bioeng 100:152–157\nPark Y, Storkson JM, Albright KJ et al (1999) Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34:235–241\nSugano M, Tsujita A, Yamasaki M (1997) Lymphatic recovery, tissue distribution, and metaboliceffects of conjugated linoleic acid in rats. J Nutr Biochem 8:38–43\nIversen SA, Cawood P, Madigan MJ et al (1984) Identification of a diene conjugated component of human lipid as octadeca-9,11-dienoic acid. FEBS Lett 171:320–324\nBadinga L, Greene ES (2006) Physiological properties of conjugated linoleic acid and implications for human health. Nutr Clin Pract 21:367–373\nTricon S, Yaqoob P (2006) Conjugated linoleic acid and human health: a critical evaluation of the evidence. Curr Opin Clin Nutr Metab Care 9:105–110\nDhiman TR, Nam SH, Ure AL (2005) Factors affecting conjugated linoleic acid content in milk and meat. Crit Rev Food Sci Nutr 45:463–482\nNudda A, Mele M, Battacone G et al (2003) Comparison of conjugated linoleic acid (CLA) content in milk of ewes and goats with the same dietary regimen. Ital J Anim Sci 2[Suppl 1]:515–517",{"EN":1869},"This study was conducted on sheep’s milk to determine the fat composition in flocks of different breeds (Suffolk, Fabrianese, Sopravvissana, Sarda) living in Marche region areas (central Italy). Samples were collected from December to July and the fatty acid profile, cholesterol content and lipid peroxidation status were analysed. The results show high levels of saturated fatty acids (SAT) for each period of the year considered. The amount of monounsaturated fatty acids (MUFA) is three to five times higher than polyunsaturated ones (PUFA). An increase in PUFA content is present in samples collected in May and July. The content of cis-9,trans-11- and trans-10,cis-12-CLA isomers increases in May, reaching the highest values in July. The results reported here are of importance since the conjugated linoleic acids (CLA) content in cheese will depend on the CLA content of milk itself and this should be taken into account due to the beneficial effects of CLA isomers on human health.",{"EN":1871},"Seasonal variation of fat composition in sheep’s milk from areas of central Italy",{"VOID":1873},"10.1007\u002Fs12349-009-0057-0","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12349-009-0057-0",[1876,1891,1903,1918,1935],{"id":1877,"sortIndex":70,"researcher":22,"roles":1878,"affiliations":1879,"properties":1888},"1bb7c7b7-df32-4784-9172-f296c5a7f6e7",[767],[1880],{"id":22,"sortIndex":23,"affiliation":1881,"properties":22},{"id":1882,"createTime":1883,"updateTime":1883,"relativeEntities":1884,"slug":22,"properties":1885,"entityType":59,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"95227e6f-85e6-41bf-a888-79727408dcc0","2024-02-21T21:41:34.476+00:00",[],{"title":1886},{"VI":1887},"Department of M.C.A. 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HM, Bishop KS (1922) On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 56:650–651\nEmerson OH, Emerson GA, Evans HM (1936) The isolation from cottonseed oil of an alcohol resembling alpha tocopherol from wheat germ oil. Science 83:421\nEmerson OH, Emerson GA, Evans HM (1939) The occurrence of gamma tocopherol in corn embryo oil. Science 89:183\nWhittle KJ, Dunphy PJ, Pennock JF (1966) The isolation and properties of delta-tocotrienol from Hevea latex. Biochem J 100:138–145\nPennock JF, Hemming FW, Kerr JD (1964) A reassessment of tocopherol in chemistry. Biochem Biophys Res Commun 17:542–548\nHerrera E, Barbas C (2001) Vitamin E: action, metabolism and perspectives. J Physiol Biochem 57:43–56\nPacker L, Weber SU, Rimbach G (2001) Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J Nutr 131:369S–373S\nBauernfeind JB (1980) Tocopherols in food. Vitamin E. Comprehensive treatise. Marcel Dekker, New York, pp 99–167\nBurton GW, Traber MG (1990) Vitamin E: antioxidant activity, biokinetics, and bioavailability. Annu Rev Nutr 10:357–382\nBirringer M, EyTina JH, Salvatore BA, Neuzil J (2003) Vitamin E analogues as inducers of apoptosis: structure and function relation. Br J Cancer 88:1948–1955\nCerecetto H, López GV (2007) Antioxidants derived from vitamin E: an overview. Mini Rev Med Chem 7:315–338\nBartlett HE, Eperjesi F (2008) Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt 28:503–523\nCatignani GL, Bieri JG (1977) Rat liver alpha-tocopherol binding protein. Biochim Biophys Acta 497:349–357\nHosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H, Inoue K (1997) Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 409:105–108\nKostner GM, Oettl K, Jauhiainen M, Ehnholm C, Esterbauer H, Dieplinger H (1995) Human plasma phospholipid transfer protein accelerates exchange\u002Ftransfer of alpha-tocopherol between lipoproteins and cells. Biochem J 305:659–667\nGoti D, Reicher H, Malle E, Kostner GM, Panzenboeck U, Sattler W (1998) High-density lipoprotein (HDL3)-associated alpha-tocopherol is taken up by HepG2 cells via the selective uptake pathway and resecreted with endogenously synthesized apo-lipoprotein B-rich lipoprotein particles. Biochem J 332:57–65\nFechner H, Schlame M, Guthmann F, Stevens PA, Rustow B (1998) Alpha- and delta-tocopherol induce expression of hepatic alpha-tocopherol-transfer-protein mRNA. Biochem J 331:577–581\nYokota T, Shiojiri T, Gotoda T, Arita M, Arai H, Ohga T, Kanda T, Suzuki J, Imai T, Matsumoto H, Harino S, Kiyosawa M, Mizusawa H, Inoue K (1997) Friedreich-like ataxia with retinitis pigmentosa caused by the His101Gln mutation of the alpha-tocopherol transfer protein gene. Ann Neurol 41:826–832\nRoxborough HE, Burton GW, Kelly FJ (2000) Inter- and intra-individual variation in plasma and red blood cell vitamin E after supplementation. Free Radic Res 33:437–445\nBrigelius-Flohe R, Kelly FJ, Salonen JT, Neuzil J, Zingg JM, Azzi A (2002) The European perspective on vitamin E: current knowledge and future research. Am J Clin Nutr 76:703–716\nDrevon CA (1991) Absorption, transport and metabolism of vitamin E. Free Radic Res Commun 14:229–246\nCopp RP, Wisniewski T, Hentati F, Larnaout A, Ben Hamida M, Kayden HJ (1999) Localization of alphatocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders. Brain Res 822:80–87\nTamaru Y, Hirano M, Kusaka H, Ito H, Imai T, Ueno S (1997) Alpha-tocopherol transfer protein gene: exon skipping of all transcripts causes ataxia. Neurology 49:584–588\nDebier C (2007) Vitamin E during pre- and postnatal periods. Vitam Horm 76:357–373\nKempnà P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A (2003) Cloning of novel human SEC14p like proteins: cellular localization, ligand binding and functional properties. Free Radic Biol Med 34:1458–1472\nBrigelius-Flohé R (2006) Bioactivity of vitamin E. Nutr Res Rev 19:174–186\nWang X, Quinn PJ (2000) The location and function of vitamin E in membranes (review). Mol Membr Biol 17:143–156\nFukuzawa K (2008) Dynamics of lipid peroxidation and antioxidation of alpha-tocopherol in membranes. J Nutr Sci Vitaminol 54:273–285\nVivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ (2003) Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361:2017–2023\nMunteanu A, Zingg JM, Azzi A (2004) Anti-atherosclerotic effects of vitamin E—myth or reality? J Cell Mol Med 8:59–76\nWorld Health Organization (2006) WHO definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Cambridge University Press, Cambridge\nWatkins P, Amiel S, Howell S, Turner E (2003) Epidemiology of diabetes. In: Watkins P, Amiel S, Howell S, Turner E (eds) Diabetes and its management. Blackwell Publishing, Oxford, pp 16–22\nHonarbakhsh S, Schachter M (2009) Vitamins and cardiovascular disease. Br J Nutr 101:1113–1131\nGiugliano D, Ceriello A, Paolisso G (1996) Oxidative stress and diabetic vascular complications. Diabetes Care 19:257–265\nLiu S, Lee IM, Song Y, Van Denburgh M, Cook NR, Manson JE, Buring JE (2006) Vitamin E and risk of type 2 diabetes in the women’s health study randomized controlled trial. Diabetes 55:2856–2862\nLee IM, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, Hennekens CH, Buring JE (2005) Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial. JAMA 294:56–65\nWard NC, Wu JH, Clarke MW, Puddey IB, Burke V, Croft KD, Hodgson JM (2007) The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. J Hypertens 25:227–234\nWu JHY, Ward NC, Indrawan AP, Almeida CA, Hodgson JM, Proudfoot JM, Puddey IB, Croft KD (2007) Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes. Clin Chem 53:511–519\nMcSorley PT, Bell PM, Young IS, Atkinson AB, Sheridan B, Fee JP, McCance DR (2005) Endothelial function, insulin action and cardiovascular risk factors in young healthy adult offspring of parents with type 2 diabetes: effect of vitamin E in a randomized double-blind, controlled clinical trial. Diabet Med 22:703–710\nBoshtam M, Rafiei M, Golshadi ID, Ani M, Shirani Z, Rostamshirazi M (2005) Long-term effects of oral vitamin E supplement in type II diabetic patients. Int J Vitam Nutr Res 75:341–346\nBle-Castillo J, Carmona-Diaz E, Mendez J, Larios-Medina F, Mediina-Santillam R, Cleva-Villanueva G, Diaz-Zagoya J (2005) Effect of α-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics. Biomed Pharmacother 59:290–295\nClarke MW, Ward NC, Wu JH, Hodgson JM, Puddey IB, Croft KD (2006) Supplementation with mixed tocopherols increases serum and blood cell gammatocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes. Am J Clin Nutr 83:95–102\nUlker S, McMaster D, McKeown PP, Bayraktutan U (2004) Antioxidant vitamins C and E ameliorate hyperglycemia-induced oxidative stress in coronary endothelial cells. Diabetes Obes Metab 6:442–451\nCinar MG, Ulker S, Alper G, Evinc A (2001) Effect of dietary vitamin E supplementation on vascular reactivity of the thoracic aorta in streptozotocin-diabetic rats. Pharmacology 62:56–64\nGocmen C, Secilmis A, Kumcu EK, Ertug PU, Onder S, Dikmen A, Baysal F (2000) Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. Eur J Pharmacol 398:93–98\nKeegan A, Walbank H, Cotter MA, Cameron NE (1995) Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta. Diabetologia 38:1475–1478\nKunisaki M, Bursell SE, Clermont AC, Ishii H, Ballas LM, Jirousek MR, Umeda F, Nawata H, King GL (1995) Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol 269:E239–E246\nKarasu C, Ozansoy G, Bozkurt O, Erdogan D, Omeroglu S (1997) Antioxidant and triglyceride-lowering effects of vitamin E associated with the prevention of abnormalities in the reactivity and morphology of aorta from streptozotocin diabetic rats. Antioxidants in Diabetes-Induced Complications (ADIC) Study. Metabolism 46:872–879\nKarasu C, Ozansoy G, Bozkurt O, Erdogan D, Omeroglu S (1997) Changes in isoprenaline-induced endothelium-dependent and -independent relaxations of aorta in long-term STZ-diabetic rats: reversal effects of dietary vitamin E. Gen Pharmacol 29:561–567\nDhein S, Kabat A, Olbrich A, Rösen P, Schröder H, Mohr FW (2003) Effect of chronic treatment with vitamin E on endothelial dysfunction in a type I in vivo diabetes mellitus model and in vitro. J Pharmacol Exp Ther 305:114–122\nGutierrez AD, de Serna DG, Robinson I, Schade DS (2009) The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C. Metabolism 58:469–478\nChui MH, Greenwood CE (2008) Antioxidant vitamins reduce acute meal-induced memory deficits in adults with type 2 diabetes. Nutr Res 28:423–429\nRizzo MR, Abbatecola AM, Barbieri M, Vietri MT, Cioffi M, Grella R, Molinari A, Forsey R, Powell J, Paolisso G (2008) Evidence for anti-inflammatory effects of combined administration of vitamin E and C in older persons with impaired fasting glucose: impact on insulin action. J Am Coll Nutr 27:505–511\nClarke MW, Burnett JR, Croft KD (2008) Vitamin E in human health and disease. Crit Rev Clin Lab Sci 45:417–450\nThe Heart Outcomes Prevention Evaluation (HOPE) Study Investigators (2000) Vitamin E supplementation, cardiovascular events in high risk patients. N Engl J Med 342:154–160\nGISSI-Prevenzione Investigators (1999) Dietary supplementation with n-3 polyunsaturated fatty acids, vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354:447–455\nStephens NG, Parsons A, Schofeld PM, Kelly F, Cheeseman K, Mitchinson MJ (1996) Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347:781–786\nFrank M, Lache O, Enav B, Szafranek T, Levy NS, Ricklis RM, Levy AP (2001) Structure\u002Ffunction analysis of the anti-oxidant properties of haptoglobin. Blood 98:3693–3698\nAsleh R, Guetta J, Kalet-Litman S, Miller-Lotan R, Levy AP (2005) Haptoglobin genotype and diabetes dependent differences in iron mediated oxidative stress in vitro and in vivo. Circ Res 96:435–441\nLevy AP, Purosothaman KR, Levy NS, Purosothaman M, Strauss M, Asleh R, Marsh S, Cohen O, Moestrup SK, Moller HJ, Zias EA, Benhayon D, Fuster V, Moreno PR (2007) Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2–2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability. Circ Res 101:106–110\nMilman U, Blum S, Shapira C, Aronson D, Miller-Lotan R, Anbinder Y, Alshiek J, Bennett L, Kostenko M, Landau M, Keidar S, Levy Y, Khemlin A, Radan A, Levy AP (2008) Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2–2 genotype: a prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol 28:341–347\nVignini A, Nanetti L, Moroni C, Testa R, Sirolla C, Marra M, Manfrini S, Fumelli D, Marcheselli F, Mazzanti L, Rabini RA (2008) A study on the action of vitamin E supplementation on plasminogen activator inhibitor type 1 and platelet nitric oxide production in type 2 diabetic patients. Nutr Metab Cardiovasc Dis 18:15–22\nBell SJ, Grochoski GT (2008) How safe is vitamin E supplementation? Crit Rev Food Sci Nutr 48:760–774",{"EN":2040},"Natural vitamin E is a mixture of tocopherols and tocotrienols synthesized only by plants. It is very difficult to determine the optimal dietary intake of vitamin E, but there is a general agreement indicating a level of 8 mg\u002Fday (12–15 IU). This value seems to be sufficient only to prevent deficiency syndromes of vitamin E. In humans, vitamin E is absorbed together with nutritional lipids in the proximal part of the intestine and released in the lymph within chylomicrons. Vitamin E supplementation, as other minerals and vitamins, is able to participate in the decrease of oxidative stress in diabetic patients by improving glycemic control and\u002For by other mechanisms related to its antioxidant activity, therefore cooperating to the control of diabetic complications. Many interventional trials evaluating the effect of antioxidant supplementation on insulin resistance, plasma glucose levels and risk of T2D give inconsistent results. At present, a controversial hypothesis about the role played by vitamin E supplementation still exists. In fact, while laboratory data report great cellular and biochemical beneficial actions, clinical trials have failed to support these claims. Concerning clinical trials, the discrepancies have been attributed to differences in selection of individuals, dosage, chemical forms of vitamin E, duration of treatment, stage of the disease and geographical area. Because of these variables, further studies aimed to clarify the relationship between diabetes, cardiovascular risk factors and vitamin E are necessary.",{"EN":2042},"Vitamin E, diabetes and related diseases: an update",{"VOID":2044},"10.1007\u002Fs12349-010-0006-y","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs12349-010-0006-y",[2047,2062,2074,2085,2097,2109,2121],{"id":2048,"sortIndex":156,"researcher":22,"roles":2049,"affiliations":2050,"properties":2059},"aa69a8a9-5fb0-49e2-ac2b-b2ceef116a2e",[767],[2051],{"id":22,"sortIndex":23,"affiliation":2052,"properties":22},{"id":2053,"createTime":2054,"updateTime":2054,"relativeEntities":2055,"slug":22,"properties":2056,"entityType":59,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"bb4c3545-6094-49c5-b2df-403633e976ac","2023-12-13T21:48:57.487+00:00",[],{"title":2057},{"VI":2058},"Department of Biochemistry, Biology and Genetics, School of Medicine, 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