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Cockayne syndrome",{"VOID":305},"[\"7019850325285995156\"]",{"VOID":307},"Aamann, 2010, Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane, FASEB Journal, 24, 2334, 10.1096\u002Ffj.09-147991\nAngle, 2008, Risk of sudden death and acute life-threatening events in patients with glutaric acidemia type II, Molecular Genetics and Metabolism, 93, 36, 10.1016\u002Fj.ymgme.2007.09.015\nAnindya, 2010, A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair, Molecular Cell, 38, 637, 10.1016\u002Fj.molcel.2010.04.017\nAoyama, 1995, Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients, Journal of Clinical Investigation, 95, 2465, 10.1172\u002FJCI117947\nArnold, 2012, Human mitochondrial RNA polymerase: structure–function, mechanism and inhibition, Biochimica et Biophysica Acta, 1819, 948, 10.1016\u002Fj.bbagrm.2012.04.002\nBalaban, 2005, Mitochondria, oxidants, and aging, Cell, 120, 483, 10.1016\u002Fj.cell.2005.02.001\nBaloh, 2007, Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle, Archives of Neurology, 64, 998, 10.1001\u002Farchneur.64.7.998\nBennett, 1996, Mitochondrial short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency: a new defect of fatty acid oxidation, Pediatric Research, 39, 185, 10.1203\u002F00006450-199601000-00031\nBerquist, 2012, Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation, Nucleic Acids Research, 40, 8392, 10.1093\u002Fnar\u002Fgks565\nBerquist, 2009, Nucleic acid binding activity of human Cockayne syndrome B protein and identification of Ca(2+) as a novel metal cofactor, Journal of Molecular Biology, 391, 820, 10.1016\u002Fj.jmb.2009.06.078\nBourdon, 2007, Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion, Nature Genetics, 39, 776, 10.1038\u002Fng2040\nBove, 2011, Fighting neurodegeneration with rapamycin: mechanistic insights, Nature Reviews Neuroscience, 12, 437, 10.1038\u002Fnrn3068\nBradsher, 2002, CSB is a component of RNA pol I transcription, Molecular Cell, 10, 819, 10.1016\u002FS1097-2765(02)00678-0\nCamm, 1987, Dental treatment of a patient with Friedreich's ataxia, Special Care in Dentistry, 7, 117, 10.1111\u002Fj.1754-4505.1987.tb00619.x\nCarrozzo, 2007, SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness, Brain, 130, 862, 10.1093\u002Fbrain\u002Fawl389\nChristopher, 1977, Comparative studies of glucose-fed and glucose-starved hamster cell cultures: responses in galactose metabolism, Journal of Cellular Physiology, 90, 387, 10.1002\u002Fjcp.1040900303\nClayton, 1974, The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria, Proceedings of the National Academy of Sciences of the United States of America, 71, 2777, 10.1073\u002Fpnas.71.7.2777\nCompe, 2012, TFIIH: when transcription met DNA repair, Nature Reviews Molecular Cell Biology, 13, 343, 10.1038\u002Fnrm3350\nCorral-Debrinski, 1992, Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age, Nature Genetics, 2, 324, 10.1038\u002Fng1292-324\nde Vries, 2007, Multiple oxidative phosphorylation deficiencies in severe childhood multi-system disorders due to polymerase gamma (POLG1) mutations, European Journal of Pediatrics, 166, 229, 10.1007\u002Fs00431-006-0234-9\nDello, 2012, mTOR kinase, a key player in the regulation of glial functions: relevance for the therapy of multiple sclerosis, Glia, 61, 301, 10.1002\u002Fglia.22433\nDi, 2009, The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency, American Journal 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Investig., 3, 3, 10.1016\u002F1071-5576(95)00041-0\nVaziri, 1993, Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes, Am. J. Hum. Genet., 52, 661\nWarburton, 1989, The effect of maternal age on the frequency of trisomy: change in meiosis or in utero selection?, Prog. Clin. Biol. Res., 311, 165\nWenger, 2014, Decreased telomere length in metaphase and interphase cells from new borns with trisomy 21, Gene, 542, 87, 10.1016\u002Fj.gene.2014.03.019\nWright, 1996, Telomerase activity in human germline and embryonic tissues and cells, Dev. Genet., 18, 173, 10.1002\u002F(SICI)1520-6408(1996)18:2\u003C173::AID-DVG10>3.0.CO;2-3\nYamada-Fukunaga, 2013, Age-associated telomere shortening in mouse oocytes, Reprod Biol. Endocrinol., 11, 108, 10.1186\u002F1477-7827-11-108\nYoon, 1996, Advanced maternal age and the risk of Down syndrome characterized by meiotic stage of chromosomal error: a population-based study, Am. J. Hum. Genet., 58, 628\nYounis, 2011, Ovarian aging: latest thoughts on assessment and management, Curr. Opin. Obstet. Gynecol., 23, 427, 10.1097\u002FGCO.0b013e32834b92b0\nZhao, 2011, Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome, Dement. Geriatr. Cogn. Disord., 32, 241, 10.1159\u002F000334522\nZigman, 2013, Atypical aging in Down syndrome, Dev. Disabil. Res. 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Nat., 57, 153, 10.1086\u002F279913","https:\u002F\u002Fdoi.org\u002F10.1086\u002F279913",{"mag":1348,"openalex":1349,"doi":1350},"2075910541","W2075910541","10.1086\u002F279913",{"id":1352,"text":1353,"url":1354,"identifiers":1355},"78aeebe3-423a-4838-8094-0f60045db3bd","Hall, 1969, Age-dependent enzyme changes in Drosophila melanogaster, Exp. Gerontol., 4, 207, 10.1016\u002F0531-5565(69)90009-6","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0531556569900096",{"doi":1356},"10.1016\u002F0531-5565(69)90009-6",{"id":1358,"text":1359,"url":1360,"identifiers":1361},"d154531c-8152-419f-acfa-d48c6dd0e5fd","Ganetzky, 1978, On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster, Exp. 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Biol., 53, 481, 10.1016\u002FS0022-5193(75)80018-X","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS002251937580018X",{"doi":1415},"10.1016\u002Fs0022-5193(75)80018-x",{"id":1417,"createTime":1418,"updateTime":1419,"relativeEntities":1420,"slug":1421,"properties":1422,"entityType":95,"verifyStatus":96,"verifyTime":1431,"verifyNote":98,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1432,"fullTextUrl":18,"authors":1433,"publicationType":131,"publisherRelationship":1501,"citationCount":1542,"citationInfo":1543,"publishDate":1546,"publishYear":1544,"citationAnalyzeStatus":1027,"lastCitationAnalyze":1547,"indexDatabases":1548,"openAccess":18,"references":18,"isForceReanalyzing":294},"d0fcb263-2f35-409d-80a4-96cf31fbb897","2024-02-13T19:59:44.686+00:00","2026-07-23T18:29:30.390+00:00",[],"Is-aging-preprogrammed-Observations-from-the-brain-gut-axis",{"title":1423,"gsPaper":1425,"references":1427,"doi":1429},{"EN":1424},"Is aging preprogrammed? Observations from the brain\u002Fgut axis",{"VOID":1426},"[\"10879356956854171994\"]",{"VOID":1428},"Seshadri, 1990, Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts, Science, 247, 205, 10.1126\u002Fscience.2104680\nStein, 1990, Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts, Science, 249, 666, 10.1126\u002Fscience.2166342\nDeCaprio, 1989, The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element, Cell, 58, 1085, 10.1016\u002F0092-8674(89)90507-2\nScarpa, 1987, Age dependence of the level of the enzymes involved in the protection against active oxygen species in the rat brain, 185, 129\nHayflick, 1985, Theories of biological aging, Exp. Gerontol., 20, 145, 10.1016\u002F0531-5565(85)90032-4\nDawkins, 1979\nFriedman, 1985, Differential expression of the mouse cholecystokinin gene during brain and gut development, Proc. Natl. Acad. Sci. 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Neurochem., 24, 337, 10.1111\u002Fj.1471-4159.1975.tb11885.x\nBaker, 1989, Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas, Science, 244, 217, 10.1126\u002Fscience.2649981",{"VOID":1430},"10.1016\u002F0047-6374(91)90010-w","2024-05-07T07:00:29.455+00:00","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F004763749190010W",[1434,1458,1473,1486],{"id":1435,"sortIndex":19,"researcher":18,"roles":1436,"affiliations":1437,"properties":1455,"displayName":1457,"givenName":18,"familyName":18},"d1c9d752-64f9-4841-b196-e60562075d6f",[104],[1438,1446],{"id":1439,"sortIndex":19,"affiliation":1440,"properties":18},"705bc2bb-623c-4bce-8930-c3c55d642294",{"id":1439,"createTime":18,"updateTime":18,"relativeEntities":1441,"slug":18,"properties":1442,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1445,"statistic":18},[],{"title":1443},{"VI":1444},"Department of Surgery, Mount Sinai School of Medicine, New York, NY U.S.A.",[],{"id":1447,"sortIndex":119,"affiliation":1448,"properties":1454},"34be3877-4510-4f08-9a25-9c2b7e8afff5",{"id":1447,"createTime":18,"updateTime":18,"relativeEntities":1449,"slug":18,"properties":1450,"entityType":18,"verifyStatus":18,"verifyTime":18,"verifyNote":18,"languages":18,"translateLanguages":18,"viewCount":18,"url":18,"parentIds":1453,"statistic":18},[],{"title":1451},{"VI":1452},"Solomon A. 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Commun., 243, 416, 10.1006\u002Fbbrc.1997.7975\nMigliaccio, 1999, The p66Shc adaptor protein controls oxidative stress response and life span in mammals, Nature, 402, 309, 10.1038\u002F46311\nMooijaart, 2004, Variation in the SHC1 gene and longevity in humans, Exp. Gerontol., 39, 263, 10.1016\u002Fj.exger.2003.10.001\nNapoli, 2003, Deletion of the p66shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet, Proc. Natl. Acad. Sci. U.S.A., 100, 2112, 10.1073\u002Fpnas.0336359100\nPacini, 2004, p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells, Mol. Cell. Biol., 24, 1747, 10.1128\u002FMCB.24.4.1747-1757.2004\nPelicci, 1996, A family of Shc related proteins with conserved PTB, CH1 and SH2 regions, Oncogene, 13, 633\nPelicci, 1992, A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction, Cell, 70, 93, 10.1016\u002F0092-8674(92)90536-L\nRichardson, 2003, Impact of aging on DNA methylation, Ageing Res. Rev., 2, 245, 10.1016\u002FS1568-1637(03)00010-2\nTrinei, 2002, A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis, Oncogene, 21, 3872, 10.1038\u002Fsj.onc.1205513\nVentura, 2002, The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter, J. Biol. 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