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PLINK: a tool set for whole-genome association and population-based linkage analyses., Am J Hum Genet, 81, 559, 10.1086\u002F519795",{"doi":1714},"10.1086\u002F519795",{"id":1716,"createTime":1717,"updateTime":1717,"relativeEntities":1718,"slug":1719,"properties":1720,"entityType":139,"verifyStatus":140,"verifyTime":1717,"verifyNote":141,"languages":1731,"translateLanguages":24,"viewCount":25,"primaryUrl":1732,"fullTextUrl":24,"authors":1733,"publicationType":307,"publisherRelationship":1824,"citationCount":1878,"citationInfo":1879,"publishDate":1881,"publishYear":726,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1882,"openAccess":24,"references":1883,"isForceReanalyzing":529},"18135aca-c3c0-4e75-8dda-be66b243fd14","2025-01-28T11:48:13.927+00:00",[],"Analysis-of-a-Previously-Identified-Pain-Protective-Haplotype-and-Individual-Polymorphisms-in-the-GCH1-Gene-in-Africans-With-HIV-Associated-Sensory-Neuropathy",{"openalex":1721,"mag":1723,"title":1725,"pm":1727,"doi":1729},{"VOID":1722},"W2037890420",{"VOID":1724},"2037890420",{"EN":1726},"Analysis of a Previously Identified “Pain-Protective” Haplotype and Individual Polymorphisms in the GCH1 Gene in Africans With HIV-Associated Sensory Neuropathy",{"VOID":1728},"22293547",{"VOID":1730},"10.1097\u002Fqai.0b013e31824bcc17",[143],"https:\u002F\u002Fjournals.lww.com\u002F00126334-201205010-00004",[1734,1756,1772,1791,1810],{"id":1735,"sortIndex":25,"researcher":24,"roles":1736,"affiliations":1737,"properties":1752,"displayName":1560,"givenName":24,"familyName":24},"d1b37c32-788f-4fc3-ad83-adc0d22d26b7",[],[1738,1746],{"id":1739,"sortIndex":25,"affiliation":1740,"properties":24},"99bdc647-3728-48fc-85e0-46f50e7cccb2",{"id":1739,"createTime":24,"updateTime":24,"relativeEntities":1741,"slug":24,"properties":1742,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1745,"statistic":24},[],{"title":1743},{"EN":1744},"Antonia L. 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Cherry",{"VOID":1790},"A5009731100",{"id":1792,"sortIndex":201,"researcher":24,"roles":1793,"affiliations":1794,"properties":1803,"displayName":1807,"givenName":24,"familyName":24},"5407eb27-6c5a-40d2-8ecd-97f1e34cbe86",[],[1795],{"id":1796,"sortIndex":25,"affiliation":1797,"properties":24},"81058f51-5cae-43c3-a3ce-613fbfa7ee6b",{"id":1796,"createTime":24,"updateTime":24,"relativeEntities":1798,"slug":24,"properties":1799,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1802,"statistic":24},[],{"title":1800},{"VI":1801},"School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia",[],{"orcid":1804,"title":1806,"openalex":1808},{"VOID":1805},"https:\u002F\u002Forcid.org\u002F0000-0003-3078-4451",{"EN":1807},"Patricia Price",{"VOID":1809},"A5023231822",{"id":1811,"sortIndex":219,"researcher":24,"roles":1812,"affiliations":1813,"properties":1820,"displayName":1577,"givenName":24,"familyName":24},"f8dcad17-c0e7-4084-8120-3d7558a0119b",[],[1814],{"id":1549,"sortIndex":25,"affiliation":1815,"properties":24},{"id":1549,"createTime":24,"updateTime":24,"relativeEntities":1816,"slug":24,"properties":1817,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1819,"statistic":24},[],{"title":1818},{"VI":1554},[],{"orcid":1821,"title":1822,"openalex":1823},{"VOID":1575},{"EN":1577},{"VOID":1579},{"url":24,"publisher":1825,"properties":1872},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1826,"slug":10,"properties":1827,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1832,"manageAffiliations":1841,"indexDatabases":1852,"url":91,"thumbnailPath":24,"statistic":1867,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1828,"eissn":1829,"issn":1830,"title":1831},{"VOID":13},{"VOID":15},{"VOID":17},{"EN":19},[1833,1837],{"id":28,"createTime":24,"updateTime":24,"relativeEntities":1834,"label":1835,"description":1836,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":31},{},{"id":34,"createTime":24,"updateTime":24,"relativeEntities":1838,"label":1839,"description":1840,"parentId":24,"standard":24,"scholarHubFieldId":24},[],{"EN":37},{},[1842,1847],{"id":41,"createTime":24,"updateTime":24,"relativeEntities":1843,"slug":24,"properties":1844,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1846,"statistic":24},[],{"title":1845},{"EN":45},[],{"id":48,"createTime":24,"updateTime":24,"relativeEntities":1848,"slug":24,"properties":1849,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1851,"statistic":24},[],{"title":1850},{"EN":52},[],[1853,1860],{"id":56,"indexDatabase":1854,"url":67,"indexYears":68,"academicFieldIds":1859,"indexDatabaseRanking":72},{"id":58,"createTime":24,"updateTime":24,"relativeEntities":1855,"label":1856,"description":1857,"key":64,"publicationTags":1858,"standard":24},[],{"EN":61,"VI":61},{"EN":61,"VI":63},[66],[70,71],{"id":74,"indexDatabase":1861,"url":87,"indexYears":24,"academicFieldIds":1866,"indexDatabaseRanking":24},{"id":76,"createTime":24,"updateTime":24,"relativeEntities":1862,"label":1863,"description":1864,"key":83,"publicationTags":1865,"standard":24},[],{"EN":79,"VI":79},{"EN":81,"VI":82},[85,86],[89,90],{"impactFactor":25,"impactFactorByYear":1868,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":100,"totalPublicationByYear":1869,"totalCitation":104,"totalCitationByYear":1870,"totalCitationPerPublication":113,"totalCitationPerPublicationByYear":1871,"hindexLast5Year":100,"hindex":100},{"2012":94,"2013":95,"2014":96,"2016":97,"2017":98,"2018":99},{"2004":102,"2005":102,"2007":102,"2011":102,"2012":102,"2015":102,"2016":103},{"2004":106,"2005":107,"2007":108,"2011":109,"2012":110,"2015":111,"2016":112},{"2004":106,"2005":107,"2007":108,"2011":109,"2012":110,"2015":111,"2016":115},{"issue":1873,"pages":1874,"volume":1876},{"VOID":721},{"VOID":1875},"20-23",{"VOID":1877},"60",18,{"total":1878,"publishYear":726,"statisticByYear":1880},{"2012":103,"2013":103,"2014":201,"2015":103,"2017":219,"2018":201,"2019":102,"2024":102},"2012-05-01",[85,72],[1884,1887,1891,1893,1897,1901,1905,1908,1910,1912,1916,1918,1920,1922,1926,1928,1932,1936,1940,1944,1948,1950,1954,1958,1962,1966,1969,1972],{"id":24,"text":1885,"url":24,"identifiers":1886},"Affandi, 2008, Imran D, et al.., Can we predict neuropathy risk before stavudine prescription in a resource-limited setting AIDS Res Hum Retroviruses, 24, 1281",{},{"id":24,"text":1888,"url":24,"identifiers":1889},"van Oosterhout, 2005, . Evaluation of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi., Trop Med Int Health, 10, 464, 10.1111\u002Fj.1365-3156.2005.01409.x",{"doi":1890},"10.1111\u002Fj.1365-3156.2005.01409.x",{"id":24,"text":1653,"url":24,"identifiers":1892},{"doi":1655},{"id":24,"text":1894,"url":24,"identifiers":1895},"Smyth, 2007, . Prevalence of and risk factors for HIV-associated neuropathy in Melbourne, Australia 1993-2006., HIV Med, 8, 367, 10.1111\u002Fj.1468-1293.2007.00478.x",{"doi":1896},"10.1111\u002Fj.1468-1293.2007.00478.x",{"id":24,"text":1898,"url":24,"identifiers":1899},"Maritz, 2010, . HIV neuropathy in South Africans: frequency, characteristics, and risk factors., Muscle Nerve, 41, 599, 10.1002\u002Fmus.21535",{"doi":1900},"10.1002\u002Fmus.21535",{"id":24,"text":1902,"url":24,"identifiers":1903},"Doth, 2010, . The burden of neuropathic pain: A systematic review and meta-analysis of health utilities., Pain, 149, 338, 10.1016\u002Fj.pain.2010.02.034",{"doi":1904},"10.1016\u002Fj.pain.2010.02.034",{"id":24,"text":1906,"url":24,"identifiers":1907},"Phillips, 2010, . Pharmacological treatment of painful HIV-associated sensory neuropathy: A systematic review and meta-analysis of randomised controlled trials., PLoS One, 5, e14433, 10.1371\u002Fjournal.pone.0014433",{"doi":1647},{"id":24,"text":1669,"url":24,"identifiers":1909},{"doi":1671},{"id":24,"text":1673,"url":24,"identifiers":1911},{"doi":1675},{"id":24,"text":1913,"url":24,"identifiers":1914},"Tegeder, 2008, . Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype., Eur J Pain, 12, 1069, 10.1016\u002Fj.ejpain.2008.02.004",{"doi":1915},"10.1016\u002Fj.ejpain.2008.02.004",{"id":24,"text":1677,"url":24,"identifiers":1917},{"doi":1679},{"id":24,"text":1681,"url":24,"identifiers":1919},{"doi":1683},{"id":24,"text":1693,"url":24,"identifiers":1921},{"doi":1695},{"id":24,"text":1923,"url":24,"identifiers":1924},"Miller, 1988, A simple salting out procedure for extracting DNA from human nucleated cells., Nucleic Acids Res, 16, 1215, 10.1093\u002Fnar\u002F16.3.1215",{"doi":1925},"10.1093\u002Fnar\u002F16.3.1215",{"id":24,"text":1712,"url":24,"identifiers":1927},{"doi":1714},{"id":24,"text":1929,"url":24,"identifiers":1930},"Clarke, 2011, . Basic statistical analysis in genetic case-control studies., Nat Protoc, 6, 121, 10.1038\u002Fnprot.2010.182",{"doi":1931},"10.1038\u002Fnprot.2010.182",{"id":24,"text":1933,"url":24,"identifiers":1934},"Aouizerat, 2010, . Risk factors and symptoms associated with pain in HIV-infected adults., J Assoc Nurses AIDS Care, 21, 125, 10.1016\u002Fj.jana.2009.10.003",{"doi":1935},"10.1016\u002Fj.jana.2009.10.003",{"id":24,"text":1937,"url":24,"identifiers":1938},"Dieleman, 2008, . Incidence rates and treatment of neuropathic pain conditions in the general population., Pain, 137, 681, 10.1016\u002Fj.pain.2008.03.002",{"doi":1939},"10.1016\u002Fj.pain.2008.03.002",{"id":24,"text":1941,"url":24,"identifiers":1942},"Polydefkis, 2002, . Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy., Neurology, 58, 115, 10.1212\u002FWNL.58.1.115",{"doi":1943},"10.1212\u002FWNL.58.1.115",{"id":24,"text":1945,"url":24,"identifiers":1946},"Barrett, 2005, . Haploview: analysis and visualization of LD and haplotype maps., Bioinformatics, 21, 263, 10.1093\u002Fbioinformatics\u002Fbth457",{"doi":1947},"10.1093\u002Fbioinformatics\u002Fbth457",{"id":24,"text":1689,"url":24,"identifiers":1949},{"doi":1691},{"id":24,"text":1951,"url":24,"identifiers":1952},"Campbell, 2008, African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping., Annu Rev Genomics Hum Genet, 9, 403, 10.1146\u002Fannurev.genom.9.081307.164258",{"doi":1953},"10.1146\u002Fannurev.genom.9.081307.164258",{"id":24,"text":1955,"url":24,"identifiers":1956},"Campbell, 2009, . Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain., Pain, 141, 114, 10.1016\u002Fj.pain.2008.10.023",{"doi":1957},"10.1016\u002Fj.pain.2008.10.023",{"id":24,"text":1959,"url":24,"identifiers":1960},"Edwards, 2006, Genetic predictors of acute and chronic pain., Curr Rheumatol Rep, 8, 411, 10.1007\u002Fs11926-006-0034-2",{"doi":1961},"10.1007\u002Fs11926-006-0034-2",{"id":24,"text":1963,"url":24,"identifiers":1964},"Kim, 2009, Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research., J Pain, 10, 663, 10.1016\u002Fj.jpain.2009.04.001",{"doi":1965},"10.1016\u002Fj.jpain.2009.04.001",{"id":24,"text":1967,"url":24,"identifiers":1968},"Lazarev, 2008, Barmada MM, et al.., Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis Mol Pain, 4, 58",{},{"id":24,"text":1970,"url":24,"identifiers":1971},"Holliday, 2009, Macfarlane GJ, et al.., Do genetic predictors of pain sensitivity associate with persistent widespread pain Mol Pain, 5, 56",{},{"id":24,"text":1973,"url":24,"identifiers":1974},"Tishkoff, 2002, Genetic analysis of African populations: human evolution and complex disease., Nat Rev Genet, 3, 611, 10.1038\u002Fnrg865",{"doi":1975},"10.1038\u002Fnrg865",{"id":1977,"createTime":1978,"updateTime":1979,"relativeEntities":1980,"slug":1981,"properties":1982,"entityType":139,"verifyStatus":140,"verifyTime":2001,"verifyNote":141,"languages":2002,"translateLanguages":2003,"viewCount":25,"primaryUrl":2005,"fullTextUrl":24,"authors":2006,"publicationType":307,"publisherRelationship":2100,"citationCount":2154,"citationInfo":2155,"publishDate":2162,"publishYear":2156,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2163,"openAccess":24,"references":2164,"isForceReanalyzing":529},"07f9d496-74a3-4960-a4c3-455eee7d291a","2024-09-24T00:50:35.930+00:00","2025-01-24T13:16:38.890+00:00",[],"Global-Epidemiology-of-HIV-Infection-and-Related-Syndemics-Affecting-Transgender-People",{"mag":1983,"keywords":1985,"pmc":1987,"openalex":1989,"abstract":1991,"title":1994,"pm":1997,"doi":1999},{"VOID":1984},"2461527608",{"VI":1986},"",{"VOID":1988},"4969059",{"VOID":1990},"W2461527608",{"VI":1992,"EN":1993},"\u003Cjats:sec>\n            \u003Cjats:title>Giới thiệu:\u003C\u002Fjats:title>\n            \u003Cjats:p>Các quần thể người chuyển giới đã bị thiếu vắng trong các nghiên cứu dịch tễ học về HIV và do đó cũng thiếu thốn trong các chương trình phòng ngừa, chăm sóc và điều trị HIV. Từ năm 2012, đã có sự gia tăng đáng kể trong nghiên cứu tập trung vào người chuyển giới. Các nghiên cứu làm nổi bật gánh nặng của bệnh HIV và những yếu tố nguy cơ, bao gồm các định kiến giao thoa, như là động lực của các tình trạng đồng hiện trong các quần thể người chuyển giới. Bài tổng quan này tổng hợp dịch tễ học HIV toàn cầu gần đây và mô tả những khoảng trống hiện tại trong nghiên cứu và can thiệp để thông tin hóa việc ưu tiên nghiên cứu HIV cho các quần thể người chuyển giới.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Phương pháp:\u003C\u002Fjats:title>\n            \u003Cjats:p>Một cuộc tổng quan có hệ thống đã được thực hiện đối với tài liệu y khoa được công bố giữa ngày 1 tháng 1 năm 2012 và ngày 30 tháng 11 năm 2015. Dữ liệu tập trung vào tỷ lệ nhiễm HIV, các yếu tố nguy cơ và các tình trạng đồng hiện trong các quần thể người chuyển giới.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả:\u003C\u002Fjats:title>\n            \u003Cjats:p>Các ước tính thay đổi đáng kể theo vị trí địa lý và tiểu quần thể. Những cá nhân chuyển nữ có tỷ lệ nhiễm HIV tập trung cao nhất trên thế giới với tỷ lệ xác nhận trong phòng thí nghiệm lên tới 40%. Dữ liệu khá hiếm về các cá nhân chuyển nam; tuy nhiên, chúng cho thấy khả năng có nguy cơ cao hơn cho nam chuyển giới có quan hệ tình dục với nam (MSM). Không có dữ liệu về tỷ lệ nhiễm bệnh cho người chuyển giới ở khu vực châu Phi hạ Sahara hoặc đông Âu\u002Ftrung Á. Các dữ liệu mới nổi liên tục hỗ trợ mối liên hệ của các điều kiện đồng hiện với nguy cơ HIV trong các quần thể người chuyển giới.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Thảo luận:\u003C\u002Fjats:title>\n            \u003Cjats:p>Giải quyết các điều kiện đồng hiện và những thách thức đặc thù về giới tính là rất quan trọng để đảm bảo sự tham gia và duy trì trong phòng ngừa HIV bởi các quần thể người chuyển giới. Nghiên cứu trong tương lai nên ưu tiên: lấp đầy các khoảng trống kiến thức trong dịch tễ học HIV; làm rõ cách thức mà định kiến hình thành các yếu tố đồng hiện để tạo ra HIV và những tác động tiêu cực khác đến sức khỏe của người chuyển giới; và hiểu cách thức để thực hiện hiệu quả các can thiệp HIV cho người chuyển giới.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:sec>\n            \u003Cjats:title>Introduction:\u003C\u002Fjats:title>\n            \u003Cjats:p>Transgender populations have been underrepresented in HIV epidemiologic studies and consequently in HIV prevention, care, and treatment programs. Since 2012, there has been a dramatic increase in research focused on transgender people. Studies highlight the burden of HIV and risk determinants, including intersecting stigmas, as drivers of syndemics among transgender populations. This review synthesizes the most recent global epidemiology of HIV infection and describes current gaps in research and interventions to inform prioritization of HIV research for transgender populations.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods:\u003C\u002Fjats:title>\n            \u003Cjats:p>A systematic review was conducted of the medical literature published between January 1, 2012 and November 30, 2015. The data focused on HIV prevalence, determinants of risk, and syndemics among transgender populations.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results:\u003C\u002Fjats:title>\n            \u003Cjats:p>Estimates varied dramatically by location and subpopulation. Transfeminine individuals have some of the highest concentrated HIV epidemics in the world with laboratory-confirmed prevalence up to 40%. Data were sparse among trans masculine individuals; however, they suggest potential increased risk for trans masculine men who have sex with men (MSM). No prevalence data were available for transgender people across Sub-Saharan Africa or Eastern Europe\u002FCentral Asia. Emerging data consistently support the association of syndemic conditions with HIV risk in transgender populations.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Discussion:\u003C\u002Fjats:title>\n            \u003Cjats:p>Addressing syndemic conditions and gender-specific challenges is critical to ensure engagement and retention in HIV prevention by transgender populations. Future research should prioritize: filling knowledge gaps in HIV epidemiology; elucidating how stigma shapes syndemic factors to produce HIV and other deleterious effects on transgender health; and understanding how to effectively implement HIV interventions for transgender people.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":1995,"VI":1996},"Global Epidemiology of HIV Infection and Related Syndemics Affecting Transgender People","Đại dịch toàn cầu về nhiễm virus HIV và các điều kiện đồng hiện liên quan đến sự ảnh hưởng của người chuyển giới",{"VOID":1998},"27429185",{"VOID":2000},"10.1097\u002Fqai.0000000000001087","2024-09-24T00:50:35.929+00:00",[143],[2004],"VI","https:\u002F\u002Fjournals.lww.com\u002F00126334-201608151-00002",[2007,2026,2045,2064,2083],{"id":2008,"sortIndex":25,"researcher":24,"roles":2009,"affiliations":2010,"properties":2019,"displayName":2023,"givenName":24,"familyName":24},"b58144f0-782a-4f60-bf7c-e884647a0da5",[],[2011],{"id":2012,"sortIndex":25,"affiliation":2013,"properties":24},"1696cd30-7c26-4d84-9f57-e2a0a832efbd",{"id":2012,"createTime":24,"updateTime":24,"relativeEntities":2014,"slug":24,"properties":2015,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2018,"statistic":24},[],{"title":2016},{"VI":2017},"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD",[],{"orcid":2020,"title":2022,"openalex":2024},{"VOID":2021},"https:\u002F\u002Forcid.org\u002F0000-0001-6541-3787",{"EN":2023},"Tonia Poteat",{"VOID":2025},"A5054463066",{"id":2027,"sortIndex":102,"researcher":24,"roles":2028,"affiliations":2029,"properties":2038,"displayName":2042,"givenName":24,"familyName":24},"e9a02bc4-52ea-42fb-b4e4-93e1c538e349",[],[2030],{"id":2031,"sortIndex":25,"affiliation":2032,"properties":24},"97781e37-8195-44c1-8c86-1146660ae1ac",{"id":2031,"createTime":24,"updateTime":24,"relativeEntities":2033,"slug":24,"properties":2034,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2037,"statistic":24},[],{"title":2035},{"VI":2036},"Department of Epidemiology and Biostatistics, Western University, London, Canada",[],{"orcid":2039,"title":2041,"openalex":2043},{"VOID":2040},"https:\u002F\u002Forcid.org\u002F0000-0001-8498-9829",{"EN":2042},"Ayden I. 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           \u003Cjats:title>Thông Tin Nền:\u003C\u002Fjats:title>\n            \u003Cjats:p>Chưa có thông tin về việc khoảng cách sống còn giữa những người bị nhiễm HIV và những người không bị nhiễm HIV có quyền truy cập dịch vụ chăm sóc có còn tồn tại hay không.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Phương Pháp:\u003C\u002Fjats:title>\n            \u003Cjats:p>Chúng tôi đã tiến hành một nghiên cứu đoàn hệ trong khuôn khổ Kaiser Permanente California trong giai đoạn 1996–2011, sử dụng bảng tuổi thọ tạm thời để ước lượng số năm sống còn mong đợi (“tuổi thọ”) ở tuổi 20.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết Quả:\u003C\u002Fjats:title>\n            \u003Cjats:p>Trong số 24,768 người bị nhiễm HIV và 257,600 người không bị nhiễm HIV, có 2229 và 4970 trường hợp tử vong, tương ứng với tỷ lệ tử vong là 1827 và 326 trên 100,000 năm người. Trong giai đoạn 1996–1997, tuổi thọ mong đợi ở tuổi 20 cho những người bị nhiễm HIV và không bị nhiễm HIV lần lượt là 19.1 và 63.4 năm, với khoảng cách là 44.3 năm (khoảng tin cậy 95%: 38.4 đến 50.2). Tuổi thọ mong đợi ở tuổi 20 cho những người bị nhiễm HIV đã tăng lên 47.1 năm vào năm 2008 và 53.1 năm vào năm 2011, thu hẹp khoảng cách xuống còn 11.8 năm (8.9–14.8 năm) vào năm 2011. Trong giai đoạn 2008–2011, tuổi thọ mong đợi ở tuổi 20 cho những người bị nhiễm HIV dao động từ mức thấp nhất là 45.8 năm đối với người da đen và 46.0 năm đối với những người có tiền sử sử dụng thuốc tiêm cho đến mức cao nhất là 52.2 năm đối với người Latinh. Những người bị nhiễm HIV bắt đầu điều trị kháng retrovirus với số CD4 ≥500 tế bào trên một microlit có tuổi thọ mong đợi ở tuổi 20 là 54.5 năm trong giai đoạn 2008–2011, thu hẹp khoảng cách so với những người không bị nhiễm HIV xuống còn 7.9 năm (5.1–10.6 năm). Đối với những người bị nhiễm HIV này, khoảng cách còn thu hẹp thêm ở các nhóm phụ không có tiền sử nhiễm virus viêm gan B hoặc C, hút thuốc, lạm dụng thuốc\u002Falcohol, hoặc bất kỳ yếu tố nguy cơ nào trong số này.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết Luận:\u003C\u002Fjats:title>\n            \u003Cjats:p>Ngay cả khi được điều trị sớm và có quyền truy cập vào dịch vụ chăm sóc, vẫn tồn tại một khoảng cách 8 năm về tuổi thọ giữa những người bị nhiễm HIV so với những người không bị nhiễm HIV.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:sec>\n            \u003Cjats:title>Background:\u003C\u002Fjats:title>\n            \u003Cjats:p>It is unknown if a survival gap remains between HIV-infected and HIV-uninfected individuals with access to care.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods:\u003C\u002Fjats:title>\n            \u003Cjats:p>We conducted a cohort study within Kaiser Permanente California during 1996–2011, using abridged life tables to estimate the expected years of life remaining (“life expectancy”) at age 20.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results:\u003C\u002Fjats:title>\n            \u003Cjats:p>Among 24,768 HIV-infected and 257,600 HIV-uninfected individuals, there were 2229 and 4970 deaths, with mortality rates of 1827 and 326 per 100,000 person-years, respectively. In 1996–1997, life expectancies at age 20 for HIV-infected and HIV-uninfected individuals were 19.1 and 63.4 years, respectively, corresponding with a gap of 44.3 years (95% confidence interval: 38.4 to 50.2). Life expectancy at age 20 for HIV-infected individuals increased to 47.1 years in 2008 and 53.1 years by 2011, narrowing the gap to 11.8 years (8.9–14.8 years) in 2011. In 2008–2011, life expectancies at age 20 for HIV-infected individuals ranged from a low of 45.8 years for blacks and 46.0 years for those with a history of injection drug use to a high of 52.2 years for Hispanics. HIV-infected individuals who initiated antiretroviral therapy with CD4 ≥500 cells per microliter had a life expectancy at age 20 of 54.5 years in 2008–2011, narrowing the gap relative to HIV-uninfected individuals to 7.9 years (5.1–10.6 years). For these HIV-infected individuals, the gap narrowed further in subgroups with no history of hepatitis B or C infection, smoking, drug\u002Falcohol abuse, or any of these risk factors.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions:\u003C\u002Fjats:title>\n            \u003Cjats:p>Even with early treatment and access to care, an 8-year gap in life expectancy remains for HIV-infected compared with HIV-uninfected individuals.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":2556,"VI":2557},"Narrowing the Gap in Life Expectancy Between HIV-Infected and HIV-Uninfected Individuals With Access to Care","Giảm Thiểu Khoảng Cách Về Tuổi Thọ Giữa Những Người Bị Nhiễm HIV và Những Người Không Bị Nhiễm HIV Có Quyền Truy Cập Dịch Vụ Chăm Sóc",{"VOID":2559},"27028501",{"VOID":2561},"10.1097\u002Fqai.0000000000001014",[143],[2004],"https:\u002F\u002Fjournals.lww.com\u002F00126334-201609010-00006",[2566,2585,2604,2621,2636,2653,2672,2691,2710],{"id":2567,"sortIndex":25,"researcher":24,"roles":2568,"affiliations":2569,"properties":2578,"displayName":2582,"givenName":24,"familyName":24},"6df652a1-0d9b-4a7e-a9d4-c961eb1f7aae",[],[2570],{"id":2571,"sortIndex":25,"affiliation":2572,"properties":24},"747d926e-d9d4-41fa-824d-61c912d2ccf0",{"id":2571,"createTime":24,"updateTime":24,"relativeEntities":2573,"slug":24,"properties":2574,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2577,"statistic":24},[],{"title":2575},{"VI":2576},"Division of Research, Kaiser Permanente Northern California, Oakland, CA",[],{"orcid":2579,"title":2581,"openalex":2583},{"VOID":2580},"https:\u002F\u002Forcid.org\u002F0000-0002-8552-414X",{"EN":2582},"Julia L. 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2008, Changes in the risk of death after HIV seroconversion compared with mortality in the general population, JAMA, 300, 51, 10.1001\u002Fjama.300.1.51",{"doi":2796},"10.1001\u002Fjama.300.1.51",{"id":24,"text":2798,"url":24,"identifiers":2799},"Lima, 2007, Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy, AIDS, 21, 685, 10.1097\u002FQAD.0b013e32802ef30c",{"doi":2800},"10.1097\u002FQAD.0b013e32802ef30c",{"id":24,"text":2802,"url":24,"identifiers":2803},"Samji, 2013, Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada, PLoS One, 8, e81355, 10.1371\u002Fjournal.pone.0081355",{"doi":2804},"10.1371\u002Fjournal.pone.0081355",{"id":24,"text":2806,"url":24,"identifiers":2807},"2008, Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies, Lancet, 372, 293, 10.1016\u002FS0140-6736(08)61113-7",{"doi":2808},"10.1016\u002FS0140-6736(08)61113-7",{"id":24,"text":2810,"url":24,"identifiers":2811},"Lohse, 2007, Survival of persons with and without HIV infection in Denmark, 1995–2005, Ann Intern Med., 146, 87, 10.7326\u002F0003-4819-146-2-200701160-00003",{"doi":2812},"10.7326\u002F0003-4819-146-2-200701160-00003",{"id":24,"text":2814,"url":24,"identifiers":2815},"Patterson, 2015, Life expectancy of HIV-positive individuals on combination antiretroviral therapy in Canada, BMC Infect Dis., 15, 274, 10.1186\u002Fs12879-015-0969-x",{"doi":2816},"10.1186\u002Fs12879-015-0969-x",{"id":24,"text":2818,"url":24,"identifiers":2819},"Harrison, 2010, Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States, J Acquir Immune Defic Syndr., 53, 124, 10.1097\u002FQAI.0b013e3181b563e7",{"doi":2820},"10.1097\u002FQAI.0b013e3181b563e7",{"id":24,"text":2822,"url":24,"identifiers":2823},"May, 2011, Impact of late 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services utilization study, J Stud Alcohol., 63, 179, 10.15288\u002Fjsa.2002.63.179",{"doi":2836},"10.15288\u002Fjsa.2002.63.179",{"id":24,"text":2838,"url":24,"identifiers":2839},"Mimiaga, 2013, Substance use among HIV-infected patients engaged in primary care in the United States: findings from the centers for AIDS research network of integrated clinical systems cohort, Am J Public Health., 103, 1457, 10.2105\u002FAJPH.2012.301162",{"doi":2840},"10.2105\u002FAJPH.2012.301162",{"id":24,"text":2842,"url":24,"identifiers":2843},"Alter, 2006, Epidemiology of viral hepatitis and HIV co-infection, J Hepatol., 44, S6, 10.1016\u002Fj.jhep.2005.11.004",{"doi":2844},"10.1016\u002Fj.jhep.2005.11.004",{"id":24,"text":2846,"url":24,"identifiers":2847},"Mdodo, 2015, Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys, Ann Intern Med., 162, 335, 10.7326\u002FM14-0954",{"doi":2848},"10.7326\u002FM14-0954",{"id":24,"text":2850,"url":24,"identifiers":2851},"Patel, 2008, Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003, Ann Intern Med., 148, 728, 10.7326\u002F0003-4819-148-10-200805200-00005",{"doi":2852},"10.7326\u002F0003-4819-148-10-200805200-00005",{"id":24,"text":2854,"url":24,"identifiers":2855},"Weber, 2006, Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study, Arch Intern Med., 166, 1632, 10.1001\u002Farchinte.166.15.1632",{"doi":2856},"10.1001\u002Farchinte.166.15.1632",{"id":24,"text":2858,"url":24,"identifiers":2859},"Wada, 2013, Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984–2008, Am J Epidemiol., 177, 116, 10.1093\u002Faje\u002Fkws321",{"doi":2860},"10.1093\u002Faje\u002Fkws321",{"id":24,"text":2862,"url":24,"identifiers":2863},"Silverberg, 2011, HIV infection, immunodeficiency, viral replication, and the risk of cancer, Cancer Epidemiol Biomarkers Prev., 20, 2551, 10.1158\u002F1055-9965.EPI-11-0777",{"doi":2864},"10.1158\u002F1055-9965.EPI-11-0777",{"id":24,"text":2866,"url":24,"identifiers":2867},"Marcus, 2015, Differences in response to antiretroviral therapy by sex and hepatitis C infection status, AIDS Patient Care STDS., 29, 370, 10.1089\u002Fapc.2015.0040",{"doi":2868},"10.1089\u002Fapc.2015.0040",{"id":24,"text":2870,"url":24,"identifiers":2871},"Lee, 2012, Analysis of overdispersed count data: application to the human Papillomavirus infection in men (HIM) study, Epidemiol Infect., 140, 1087, 10.1017\u002FS095026881100166X",{"doi":2872},"10.1017\u002FS095026881100166X",{"id":24,"text":2874,"url":24,"identifiers":2875},"Arias, 2014, United States life tables, 2010, Natl Vital Stat 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