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Neurochem., 65, 1250, 10.1046\u002Fj.1471-4159.1995.65031250.x\nGluckman, 2005, Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial, Lancet, 365, 663, 10.1016\u002FS0140-6736(05)17946-X\nHachimi-Idrissi, 2004, Postischemic mild hypothermia reduces neurotransmitter release and astroglial cell proliferation during reperfusion after asphyxial cardiac arrest in rats, Brain Res., 1019, 217, 10.1016\u002Fj.brainres.2004.06.013\nHolopainen, 2005, Organotypic hippocampal slice cultures: A model system to study basic cellular and molecular mechanisms of neuronal cell death, neuroprotection, and synaptic plasticity, Neurochem. Res., 30, 1521, 10.1007\u002Fs11064-005-8829-5\nHypothermia after Cardiac Arrest Study Group, 2002, Mild therapeutic hypothermia to improve neurologic outcome after cardiac arrest, N. Engl. J. Med., 346, 549, 10.1056\u002FNEJMoa012689\nIllievich, 1994, Effects of hypothermic metabolic suppression on hippocampal glutamate concentrations after transient global cerebral ischemia, Anesth. Analg., 78, 905, 10.1213\u002F00000539-199405000-00012\nJacobs, S., Hunt, R., Tarnow-Mordi, W., Inder, T., Davis, P., 2007. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst. Rev. CD003311\nJanata, 2009, Hypothermia after cardiac arrest, Prog. Cardiovasc. Dis., 52, 168, 10.1016\u002Fj.pcad.2009.07.001\nJin, 2001, Neurogenesis in the dentate sub-granular zone and rostral subventricular zone after focal cerebral ischemia in the rat, Proc. Natl. Acad. Sci. USA, 98, 4710, 10.1073\u002Fpnas.081011098\nKaplan, 1977, Neurogenesis in the adult rat: electron microscopy analysis of light radioautographs, Science, 197, 1092, 10.1126\u002Fscience.887941\nKriz, 2006, Inflammation in ischemic brain injury: timing is important, Crit. Rev. Neurobiol., 18, 145, 10.1615\u002FCritRevNeurobiol.v18.i1-2.150\nLaake, 1999, A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence, Brain Res. Protoc., 4, 173, 10.1016\u002FS1385-299X(99)00021-5\nLasarzik, 2009, Mild hypothermia has no long-term impact on postischemic neurogenesis in rats, Anesth. Analg., 109, 1632, 10.1213\u002FANE.0b013e3181bab451\nLaywell, 2000, Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain, Proc. Nat. Acad. Sci. USA, 97, 13883, 10.1073\u002Fpnas.250471697\nLee, 2002, Hypothermia inhibits cell proliferation and nitric oxide synthase expression in rats, Neurosci. Lett., 329, 53, 10.1016\u002FS0304-3940(02)00591-8\nLiu, 1998, Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils, J. Neurosci., 18, 7768, 10.1523\u002FJNEUROSCI.18-19-07768.1998\nMorino, 2008, Microglia inhibition is a target of mild hypothermic treatment after the spinal cord injury, Spinal Cord, 46, 425, 10.1038\u002Fsj.sc.3102163\nRaineteau, 2006, Conditional labeling of newborn granule cells to visualize their integration into established circuits in hippocampal slice cultures, Mol. Cell. Neurosci., 32, 344, 10.1016\u002Fj.mcn.2006.05.006\nRaval, 2003, Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice, J. Neurosci., 23, 384, 10.1523\u002FJNEUROSCI.23-02-00384.2003\nRice, 1981, The influence of immaturity on hypoxia-ischemic brain damage in the rat, Ann. Neurol., 9, 131, 10.1002\u002Fana.410090206\nSahuquillo, 2007, Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury, Curr. Pharm. Des., 22, 2310, 10.2174\u002F138161207781368756\nSchlessinger, 1975, An autoradiographic study of the time of oritin and pattern of granule cell migration in the dentate gyrus of the rat, J. Comp. Neurol., 159, 149, 10.1002\u002Fcne.901590202\nSeki, 2002, Expression patterns of immature neuronal markers PSA-NCAM, CRMP-4, and NeuroD in the hippocampus of young adult and aged rodents, J. Neurosci., 70, 327, 10.1002\u002Fjnr.10387\nSeress, 2001, Cell formation in the human hippocampal formation from mid-gestation to the late postnatal period, Neuroscience, 105, 831, 10.1016\u002FS0306-4522(01)00156-7\nStoppini, 1991, Interface organotypic hippocampal slice cultures, J. Neurosci. Methods, 37, 173, 10.1016\u002F0165-0270(91)90128-M\nXiong, 2009, Post-ischemic hypothermia for 24h in P7 rats rescues hippocampal neuron: association with decreased astrocyte activation and inflammatory cytokine expression, Brain Res. 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2009\nAmon, 2012, The effect of a sleep high-train low regimen on the finger cold-induced vasodilation response, High. Alt. Med. Biol., 13, 32, 10.1089\u002Fham.2011.1044\nCastellani, 2002, Physiological responses to cold exposure in men: a disabled submarine study, Undersea Hyperb. Med., 29, 189\nCheung, 2007, Cold-induced vasodilatation is not homogenous or generalizable across the hand and feet, Eur. J. Appl. Physiol., 99, 701, 10.1007\u002Fs00421-006-0383-6\nCheung, 2012, Dynamic adaptation of the peripheral circulation to cold exposure, Microcirculation, 19, 65, 10.1111\u002Fj.1549-8719.2011.00126.x\nDaanen, 2000, Cold-induced peripheral vasodilation at high altitudes--a field study, High. Alt. Med. Biol., 1, 323, 10.1089\u002F15270290050502390\nDaanen, 2012, Trainability of cold induced vasodilatation in fingers and toes, Eur. J. Appl. Physiol., 112, 2595, 10.1007\u002Fs00421-011-2233-4\nFelicijan, 2008, Enhancement of cold-induced vasodilatation following acclimatization to altitude, Eur. J. Appl. Physiol., 104, 201, 10.1007\u002Fs00421-008-0720-z\nIriki, 1983, Regional differentiation of sympathetic efferents during thermal stimulation, J. Therm. Biol., 8, 225, 10.1016\u002F0306-4565(83)90109-2\nKeramidas, 2010, Enhancement of the finger cold-induced vasodilation response with exercise training, Eur. J. Appl. Physiol., 109, 133, 10.1007\u002Fs00421-010-1374-1\nKeramidas, 2014, Acute effects of normobaric hypoxia on hand-temperature responses during and after local cold stress, High. Alt. Med. Biol., 15, 183, 10.1089\u002Fham.2013.1131\nKeramidas, 2015, Hand temperature responses to local cooling after a 10-day confinement to normobaric hypoxia with and without exercise, Scand. J. Med. Sci. Sports, 25, 650, 10.1111\u002Fsms.12291\nKeramidas, 2015, Effects of two short-term, intermittent hypoxic training protocols on sea-level local cold tolerance, High. Alt. Med. Biol., 6, 51\nKounalakis, 2013, Peak oxygen uptake and regional oxygenation in response to a 10-day confinement to normobaric hypoxia, Scand. J. Med. Sci. Sports, 23, e233, 10.1111\u002Fsms.12067\nLaunay, 2006, Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level, Aviat. Space Environ. Med., 77, 1230\nLivingstone, 1976, Changes in cold-induced vasodilation during Arctic exercises, J. Appl. Physiol., 40, 455, 10.1152\u002Fjappl.1976.40.3.455\nMathew, 1977, Cold-induced vasodilatation and peripheral blood flow under local cold stress in man at altitude, Aviat. Space Environ. Med., 48, 497\nMeeuwsen, T., van Es, E.M., Smeets, B., Layden, J.D., Simons, R., Daanen, H.A.M., 2009. Reduced cold-induced vasodilation at altitude: Due to hypoxic or hypobaric circumstances? In Proceedings of the 13th International Conference on Environmental Ergonomics. Boston (USA). pp: 540–543.\nMekjavic, 2008, The trainability and contralateral response of cold-induced vasodilatation in the fingers following repeated cold exposure, Eur. J. Appl. Physiol., 104, 193, 10.1007\u002Fs00421-008-0727-5\nMekjavic, 2016, The Effect of normobaric hypoxic confinement on metabolism, gut hormones, and body composition, Front. Physiol., 7, 202, 10.3389\u002Ffphys.2016.00202\nO'Brien, 2015, Acute hypobaric hypoxia effects on finger temperature during and after local cold exposure, High. Alt. Med. Biol., 16, 244, 10.1089\u002Fham.2015.0024\nPurkayastha, 1992, Peripheral vascular response to local cold stress of tropical men during sojourn in the arctic cold region, Jpn. J. Physiol., 42, 877, 10.2170\u002Fjjphysiol.42.877\nReynolds, 2007, Cold-induced vasodilatation in the foot is not homogenous or trainable over repeated cold exposure, Eur. J. Appl. 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Steinernema feltiae, PLoS One, 11, 10.1371\u002Fjournal.pone.0156502\nBiggar, 2013, Expression of freeze-responsive proteins, Fr10 and Li16, from freeze-tolerant frogs enhances freezing survival of BmN insect cells, FASEB J., 27, 3376, 10.1096\u002Ffj.13-230573\nBischof, 2005, Thermal stability of proteins, Ann. N. Y. Acad. Sci., 2066, 12, 10.1196\u002Fannals.1363.003\nBraslavsky, 2013, LabVIEW-operated novel nanoliter osmometer for ice binding protein investigations, J. Vis. Exp., 4189\nCai, 1997, Upregulation of a novel gene by freezing exposure in the freeze-tolerant wood frog (Rana sylvatica), Gene, 198, 305, 10.1016\u002FS0378-1119(97)00332-6\nCapicciotti, 2013\nCapicciotti, 2016, O-Aryl-Glycoside ice recrystallization inhibitors as novel cryoprotectants: a structure–function study, ACS Omega, 1, 656, 10.1021\u002Facsomega.6b00163\nCostanzo, 1993, Glucose concentration regulates freeze tolerance in the wood frog Rana sylvatica, J. Exp. Biol., 181, 245, 10.1242\u002Fjeb.181.1.245\nCostanzo, 2013, Hibernation physiology, freezing adaptation and extreme freeze tolerance in a northern population of the wood frog, J. Exp. Biol., 216, 3461, 10.1242\u002Fjeb.089342\nDeng, 1998, Isolation and characterization of an antifreeze from the longhorn sculpin, Myoxocephalus octodecimspinosus, Biochim. Biophys. Acta., 1388, 305, 10.1016\u002FS0167-4838(98)00180-0\nDeng, 1997, Amino acid sequence of a new type of antifreeze protein, from the longhorn sculpin Myoxocephalus octodecimspinosis, FEBS Lett., 402, 17, 10.1016\u002FS0014-5793(96)01466-4\nDuman, 2015, Animal ice-binding (antifreeze) proteins and glycolipids: an overview with emphasis on physiological function, J. Exp. Biol., 218, 1846, 10.1242\u002Fjeb.116905\nGaede-Koehler, 2012, Direct measurement of the thermal hysteresis of antifreeze proteins (AFPs) using sonocrystallization, Anal. Chem., 84, 10229, 10.1021\u002Fac301946w\nGauthier, 2008, A re-evaluation of the role of type IV antifreeze protein, Cryobiology, 57, 292, 10.1016\u002Fj.cryobiol.2008.10.122\nKim, 2017, Marine antifreeze proteins: structure, function, and application to cryopreservation as a potential cryoprotectant, Mar. Drugs, 15, 1, 10.3390\u002Fmd15020027\nMangiagalli, 2016, Cryo-protective effect of an ice-binding protein derived from antarctic bacteria, FEBS J., 284, 163, 10.1111\u002Ffebs.13965\nMarshall, 2016, Ice-shell purification of ice-binding proteins, Cryobiology, 72, 258, 10.1016\u002Fj.cryobiol.2016.03.009\nMitchell, 2015, Gold nanoparticle aggregation as a probe of antifreeze (glyco) protein-inspired ice recrystallization inhibition and identification of new IRI active macromolecules, Sci. Rep., 5, 15716, 10.1038\u002Fsrep15716\nNowshari, 1998, Effect of cryoprotectants and their concentration on post-thaw survival and development of expanded mouse blastocysts frozen by a simple rapid-freezing procedure, Theriogenology, 50, 1001, 10.1016\u002FS0093-691X(98)00203-9\nOlijve, 2016, A simple and quantitative method to evaluate ice recrystallization kinetics using the circle, Hough Transform Algorithm, 16, 4190\nStorey, 2004, Strategies for exploration of freeze responsive gene expression: advances in vertebrate freeze tolerance, Cryobiology, 48, 134, 10.1016\u002Fj.cryobiol.2003.10.008\nStorey, 1988, Freeze tolerance in animals, Physiol. Rev., 68, 27, 10.1152\u002Fphysrev.1988.68.1.27\nStorey, 1992, Natural freeze tolerance in ectothermic vertebrates, Annu. Rev. Physiol., 54, 619, 10.1146\u002Fannurev.ph.54.030192.003155\nStorey, 2017, Molecular physiology of freeze tolerance in vertebrates, Physiol. 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Res. Commun., 157, 611, 10.1016\u002FS0006-291X(88)80294-8\nBorrelli, 1989, Evidence that the feeder effect in mammalian cells is mediated by a diffusible substance, Int. J. Hyperthermia, 5, 99, 10.3109\u002F02656738909140436\nChang, 1990, Involvement of protein synthesis in the development of thermotolerance using a CHO temperature-sensitive mutant, Int. J. Hyperthermia, 6, 105, 10.3109\u002F02656739009140808\nElder, 1984, Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide, 81, 7476\nForsdyke, 1984, Rapid qualitative changes in mRNA populations in cultured human lymphocytes: comparison of the effects of cycloheximide and concanavalin A, Can. J. Biochem. cell. Biol., 62, 859, 10.1139\u002Fo84-110\nGoldberg, 1976, Intracellular protein degradation in mammalian and bacterial cells, A. Rev. 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Hyperthermia, 6, 591, 10.3109\u002F02656739009140955\nLepock, 1990, Thermal denaturation of nuclear proteins, 35\nLepock, 1990, Increased thermostability of thermotolerant CHL V79 cells as determined by differential scanning calorimetry, J. cell. Physiol., 142, 628, 10.1002\u002Fjcp.1041420324\nLi, 1985, Elevated levels of 70,000 dalton heat shock protein in transiently thermotolerant Chinese hamster fibroblasts and in their stable heat resistant varients, Int. J. Radiat. Oncol. Biol. Phys., 11, 165, 10.1016\u002F0360-3016(85)90376-1\nLi, 1980, A proposed operational model of thermotolerance based on effects of nutrients and the initial treatment temperature, Cancer Res., 40, 4501\nLi, 1985, Induction of heat shock protein synthesis in murine tumors during the development of thermotolerance, Cancer Res., 45, 3816\nLi, 1982, Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts, 79, 3218\nLin, 1984, Modification of membrane function, protein synthesis, and heat killing effect in cultured Chinese hamster cells by glycerol and D2O, Cancer Res., 44, 5776\nLowry, 1951, Protein measurement with the Folin phenol reagent, J. biol. Chem., 193, 265, 10.1016\u002FS0021-9258(19)52451-6\nMakino, 1984, C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment, Nature (London), 310, 697, 10.1038\u002F310697a0\nMinton, 1982, Nonspecific stabilization of stress-susceptible proteins by stress-resistant proteins: a model for the biological role of heat shock proteins, 79, 7107\nPalzer, 1973, Studies on the quantitative biology of hyperthermic killing of HeLa cells, Cancer Res., 33, 415\nPelham, 1986, Speculating on the functions of the major heat shock and glucose-regulated proteins, Cell, 46, 959, 10.1016\u002F0092-8674(86)90693-8\nPrzybytkowski, 1986, Thermal adaptation in CHO cells at 40°C; the influence of growth conditions and the role of heat shock proteins, Radiat. Res., 107, 317, 10.2307\u002F3576836\nRoti Roti, 1984, Effect of alcohols, procain and hyperthermia on protein contents of nuclei and chromatin, Int. J. Radiat. 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1988, Effects of long-term heat exposure on the auditory nerve-brainstem evoked responses, J. therm. 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Neurophysiol., 47, 191, 10.1016\u002F0013-4694(79)90164-0\nGerauld, 1982, Brainstem auditory evoked potentials in multiple sclerosis, Influence of body temperature increase, 501\nGold, 1985, Effects of body temperature elevation on auditory nerve-brain-stem evoked responses and EEGs in rats, Electroenceph. clin. Neurophysiol., 60, 146, 10.1016\u002F0013-4694(85)90021-5\nHayward, 1986, Effect of mesomorphy on hyperthermia during exercise in warm, humid environment, Am. J. Phys. Anthropol., 70, 11, 10.1002\u002Fajpa.1330700104\nLiang, 1986, Longitudinal data analysis using generalized linear models, Biometrika, 73, 13, 10.1093\u002Fbiomet\u002F73.1.13\nMarshall, 1981, Circadian variation in the latency of brainstem responses and its relation to body temperature, Science, 212, 356, 10.1126\u002Fscience.7209538\nMustafa, 1988, Effect of hyperthermia on brain auditory evoked potentials in the conscious sheep, Electroenceph. clin. Neurophysiol., 71, 133, 10.1016\u002F0168-5597(88)90071-8\nPhillips, 1983, Multimodality evoked potentials and neurophysiological tests in multiple sclerosis, 40, 159\nRoberts, 1977, Skin blood flow and sweating changes following exercise training and heat acclimation, J. appl. Physiol., 43, 133, 10.1152\u002Fjappl.1977.43.1.133\nRuss, 1984, Effect of hypothermia on visual evoked potentials (VEP) in huamns, Anesthes., 61, 207, 10.1097\u002F00000542-198408000-00018\nShapiro, 1990, Field and clinical observations of exertional heat stroke patients, Med. Sci. Sport Exerc., 22, 6, 10.1249\u002F00005768-199002000-00003\nShibolet, 1967, Heatstroke, 36, 525\nShibolet, 1976, Heat stroke, A Review, Aviat. Space Environ Med., 47, 280\nSohmer, 1989, Effects of hypothermia on auditory brain-stem and somatosensory evoked responses, 74, 50\nStarr, 1975, Auditory brainstem responses in neurological disease, Arch. 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