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Enzymatic and structural properties, Eur J Biochem, 60, 9, 10.1111\u002Fj.1432-1033.1975.tb20969.x\nBertino, 1964, Studies on the inhibition of dihydrofolate reductase by the folate antagonists, J Biol Chem, 239, 479, 10.1016\u002FS0021-9258(18)51705-1\nBlakley, 1957, The reactive intermediate formed by formaldehyde and tetrahydropteroyl glutamate, Biochim Biophys Acta, 23, 654, 10.1016\u002F0006-3002(57)90395-5\nBleyer, 1978, The clinical pharmacology of methotrexate—New application of an old drug, Cancer, 41, 36, 10.1002\u002F1097-0142(197801)41:1\u003C36::AID-CNCR2820410108>3.0.CO;2-I\nBrooks, 1978, Use of dihydrofolate reductase from bovine liver, rather than from L. casei, for determining methotrexate, Clin Chem, 24, 518, 10.1093\u002Fclinchem\u002F24.3.518\nBrown, 1980, Enzymatic inhibition assay for methotrexate with a discrete analyzer the ABA-100, Clin Chem, 26, 335, 10.1093\u002Fclinchem\u002F26.2.335\nDawson, 1969, Vitamins and coenzymes\nDePorceri-Morton, 1978, Performance evaluation of the EMIT methotrexate assay\nDjerassi, 1975, High-dose methotrexate (NSC-740) and citrovorum factor (NSC-3590) rescue: Background and rationale, Cancer Treat Rep, 6, 3\nDonehower, 1979, Presence of 2,4-diamino-N10-methylpteroic acid after high-dose methotrexate, Clin Pharmacol Ther, 26, 63, 10.1002\u002Fcpt197926163\nEastham, 1977\nEpstein, 1976, Monitoring the administration of methotrexate in antimetabolite therapy, Ann Clin Lab Sci, 6, 312\nFalk, 1976, Enzymatic assay for methotrexate in serum and cerebrospinal fluid, Clin Chem, 22, 785, 10.1093\u002Fclinchem\u002F22.6.785\nFarber, 1949, Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer, Blood, 4, 160, 10.1182\u002Fblood.V4.2.160.160\nFinley, 1977, Methotrexate assay by enzymatic inhibition, with use of a centrifugal analyzer, Clin Chem, 23, 2139, 10.1093\u002Fclinchem\u002F23.11.2139\nHillcoat, 1967, Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase, Anal Biol, 21, 178, 10.1016\u002F0003-2697(67)90179-0\nJacobs, 1976, 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high-dose methotrexate, J Clin Invest, 57, 534, 10.1172\u002FJCI108308\nPersijn, 1979, A rapid enzymatic assay for methotrexate in serum, J Clin Chem Clin Biochem, 17, 235\nRowe, 1973, Dihydrofolate reductase: Studies on the activation of the bovine liver enzyme, J Biol Chem, 248, 984, 10.1016\u002FS0021-9258(19)44361-5\nScheufler, 1981, Improved enzymatic assay for methotrexate: Shape of standard curve, stability of reagents, sensitivity, Clin Chim Acta, 111, 113, 10.1016\u002F0009-8981(81)90429-0\nStoller, 1977, Use of plasma pharmacokinetics to prevent methotrexate toxicity, N Engl J Med, 297, 630, 10.1056\u002FNEJM197709222971203\nVon Hoff, 1977, Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration, Cancer Treat Rep, 61, 745\nWerkheiser, 1962, Assay for 4-amino folic acid analogues by inhibition of folic acid reductase, J Pharmacol Exp Ther, 137, 162\nWhiteley, 1968, Synthesis of 2-amino-4-hydroxy-6-formyl-7,8-dihydropteridine and its identification as a degradation product of dihydrofolate, Arch Biochem Biophys, 126, 955, 10.1016\u002F0003-9861(68)90490-6",{"EN":104},"Rapid and inexpensive enzyme inhibition assay of methotrexate",{"VOID":106},"10.1016\u002F0160-5402(86)90019-7","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0160540286900197",[109,124],{"id":110,"sortIndex":43,"researcher":18,"roles":111,"affiliations":112,"properties":121},"5e179844-dab4-4a22-9c8c-e1ec1900639c",[50],[113],{"id":18,"sortIndex":43,"affiliation":114,"properties":18},{"id":115,"createTime":116,"updateTime":116,"relativeEntities":117,"slug":18,"properties":118,"entityType":60,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":43},"78f3e1cf-3600-46fd-9fd1-6a5ff8381daa","2024-02-13T01:38:36.039+00:00",[],{"title":119},{"VI":120},"Radiation Science Laboratories, Velindre Hospital, Whitchurch, Cardiff CF4 7XL United Kingdom",{"title":122},{"VI":123},"Alan K.L. 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Symptomatic and prophylactic action in migraine, 65\nGoldberg, 1972, Cardiovascular and renal actions of dopamine: potential clinical application, Pharmacol Rev, 24, 1\nGriesemer, 1953, Potentiating effect of iproniazid on the pharmacological action of sympathomimetic amines, 84, 699\nInnes, 1962, An action of 5-hydroxytryptamine on adrenaline receptors, Brit J Pharmacol, 19, 427\nJarratt, 1971, Changes in monoamine oxidase and catechol-o-methyl transferase activities after denervation of the nictitating membrane of the cat, J Physiol (Lond), 212, 549, 10.1113\u002Fjphysiol.1971.sp009341\nKaiser, 1964, Alpha- and beta-adrenergic mechanism in the systemic venous bed, J Pharmacol Exp Ther, 144, 156\nMiller, 1975, Sensitivity of subcutaneous small arteries and veins to norepinephrine and epinephrine and isoproterenol in the unanesthetized cat, Microvascular Res, 10, 340, 10.1016\u002F0026-2862(75)90037-0\nNachev, 1971, Simplified method for measuring compliance of superficial hand veins, Cardiovasc Res, 5, 147, 10.1093\u002Fcvr\u002F5.1.147\nPerez-Reyes, 1963, Tachyphylaxis to epinephrine and its modification by cocaine, PSEBM, 112, 181\nPluchino, 1972, Direct and indirect effects of 5-hydroxytryptamine and tyramine on cat smooth muscle, Nauyn-Schmiedeberg's Arch Parmacol, 272, 189, 10.1007\u002FBF00508769\nPluchino, 1968, The influence of denervation and of decentralization on the alpha and beta effects of isoproterenol on the nictitating membrane of the pithed cat, J Pharmacol Exp Ther, 163, 257\nRumbolt, 1975, Farmacologia clinica del pindololo sui recettori venomotori, Boll Soc Ital Biol Sperim, 51, 895\nSandler, 1970, The role of tyramine in migraine: some possible biochemical mechanism, 103\nSchönbaum, 1975, An unexpected effect of serotonin antagonists on the canine nasal circulation, 15, 180\nSicuteri, 1971, Pain Syndrome in man following treatment with p-chlorophenylalanine, Pharm Res Comm, 3, 401, 10.1016\u002F0031-6989(71)90012-9\nSicuteri, 1976, Headache: disruption of pain modulation, Vol 1, 871\nSicuteri, 1977, Headache as metonymy of non organic pain, 18\nSicuteri, 1973, 5-hydroxytryptamine supersensitivity as a new theory of headache and central pain: a clinical pharmacological approach with p-chlorophenylalanine, Psychopharmacologia (Berlin), 29, 347, 10.1007\u002FBF00429282\nSicuteri, 1971, Monoamine oxidase activity in migraine and arterial hypertension, 195\nSicuteri, 1966, Variazioni di sensibilità alla 5-HT e alle catecolamine durante l'attacco emicranico. Test della venocostrizione, Boll Soc Ital Biol Sperim, 42, 843\nSicuteri, 1964, II test della venocostrizione per la misura della sensibilità alla 5-idrossitriptamina ed alle catecolamine nell'uomo, Boll Soc Ital Biol Sperim, 40, 1148\nSicuteri, 1965, Variata reattività alla 5-idrossitriptamina ed alla nor-adren-alina da antimonoaminossidasici nell'uomo, Boll Soc Ital Biol Sperim, 41, 467\nSicuteri, 1966, Alpha and Beta adrenergic receptors in human veins; activity of a new beta blocking agent, Med Pharmacol Exp, 15, 73\nSicuteri, 1964, Inibizione della venocostrizione da 5-idrossitriptamina da parte del metisergide (UML-491) e di altri antiserotoninici, Boll Soc Ital Biol Sperim, 40, 1151\nSicuteri, 1975, Sulla tachifilassi alla adrenalina: uno studio di farmacologia umana sui recettori venosi beta-adrenergici, Boll Soc Ital Biol Sperim, 51, 889\nSicuteri, 1966, Antagonismo sulla 5-HT, sulla istamina e sulla acetilcolina di un antiaminico nell'uomo. 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Part I: interaction of one or two compounds with one receptor system, Arzneim-Forsch, 6, 282\nArunlakshana, 1959, Some quantitative uses of drug antagonists, Br J Pharmacol, 14, 48\nKaumann, 1980, β-Adrenoceptor blocking agents as partial agonists in isolated heart muscle: Dissociation of stimulation and blockade, Naunyn-Schmiedeberg Arch Pharmacol, 311, 237, 10.1007\u002FBF00569403\nKukovetz, 1976, Wirkung von Fendilin auf Herz und glatte Muskulatur, Arzneim-Forsch, 26, 1321\nLevy, 1967, A comparison of the adrenergic receptor blocking properties of 1-(4'-methyl-phenyl)-2-isopropylamino-propanol-HCl and propranolol, J Pharmacol Exp Ther, 156, 452\nMüller-Schweinitzer, 1974, Investigations on the mode of action of ergotamine in the isolated femoral vein of the dog, Br J Pharmacol, 51, 441, 10.1111\u002Fj.1476-5381.1974.tb10680.x\nPöch, 1981, Quantitative Ermittlung potenzierender oder hemmender Kombinationswirkungen gleichsinnig wirkender Pharmaka. Vorteile einer Dosis-Wirkungs-Kurven-Methode gegenüber der Isobolen-Methode, Arzneim-Forsch, 31, 1135\nPöch, 1980, Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, additive dose-response curves, J Pharmacol Meth, 4, 179, 10.1016\u002F0160-5402(80)90036-4\n(Erratum 5:183).\nPöch, 1986, Simple pA2-estimation of partial agonists, Naunyn-Schmiedeberg Arch Pharmacol, 322, R1\nVan den Brink, 1977, General theory of drug-receptor interactions. Drug-receptor interaction models. 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