[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_491bcff8-27b9-489f-8fad-78f7bf0ecd95":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:491bcff8-27b9-489f-8fad-78f7bf0ecd95,\"}":108},{"code":4,"data":5,"meta":24},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":26,"manageAffiliations":35,"indexDatabases":57,"url":96,"thumbnailPath":24,"statistic":97,"gsStatistic":24,"type":24,"analyzePriority":24},"491bcff8-27b9-489f-8fad-78f7bf0ecd95","2023-05-29T10:45:24.032+00:00","2025-11-21T09:49:56.521+00:00",[],"Journal-of-Orthopaedic-Research",{"country":12,"issn":14,"introduce":16,"eissn":18,"title":20},{"VOID":13},"US",{"VOID":15},"1554527X",{"EN":17},"The Journal of Orthopaedic Research is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.",{"VOID":19},"07360266",{"EN":21},"Journal of Orthopaedic Research","PUBLISHER","PENDING",null,0,[27],{"id":28,"createTime":29,"updateTime":30,"relativeEntities":31,"label":32,"description":34,"parentId":24,"standard":24,"scholarHubFieldId":24},"ec15501b-858e-4c8d-8fba-f700ce418e56","2023-05-29T10:24:30.724+00:00","2023-11-21T08:02:49.950+00:00",[],{"EN":33},"Orthopedics and Sports Medicine",{},[36,47],{"id":37,"createTime":38,"updateTime":39,"relativeEntities":40,"slug":41,"properties":42,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":45,"url":24,"parentIds":46,"statistic":24},"b89d4fd0-cd7c-45fd-97a1-ec784c5e5841","2023-05-29T10:24:10.269+00:00","2025-11-21T10:07:36.335+00:00",[],"Wiley-Blackwell",{"title":43},{"EN":41},"AFFILIATION",8,[],{"id":48,"createTime":49,"updateTime":50,"relativeEntities":51,"slug":52,"properties":53,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":55,"url":24,"parentIds":56,"statistic":24},"43d4a537-d044-4372-8544-ca45c3bea38f","2023-05-29T12:06:07.474+00:00","2024-02-13T10:28:57.921+00:00",[],"WILEY",{"title":54},{"EN":52},6,[],[58,77],{"id":59,"indexDatabase":60,"url":74,"indexYears":24,"academicFieldIds":75,"indexDatabaseRanking":24},"2d56b58c-2b7e-429b-8f1d-89a7b6a1b049",{"id":61,"createTime":62,"updateTime":63,"relativeEntities":64,"label":65,"description":67,"key":70,"publicationTags":71,"standard":24},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":66,"VI":66},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":68,"EN":69},"Cơ sở dữ liệu SCIE","SCIE database","scie",[72,73],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0736-0266",[76],"aad2b288-5be2-4585-9802-9a6efd9082d4",{"id":78,"indexDatabase":79,"url":91,"indexYears":92,"academicFieldIds":93,"indexDatabaseRanking":95},"c056ef75-f290-417f-a13e-0262ad6ed736",{"id":80,"createTime":81,"updateTime":82,"relativeEntities":83,"label":84,"description":86,"key":88,"publicationTags":89,"standard":24},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":85,"VI":85},"Scopus - Elsevier",{"EN":85,"VI":87},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[90],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F12239","1983-2025",[94],"8a3f8173-2909-4058-aff2-7b13da6d64d8","SCOPUS__Q1","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fjournal\u002F1554527x",{"impactFactor":25,"impactFactorByYear":98,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":100,"totalCitation":25,"totalCitationByYear":106,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":107,"hindexLast5Year":25,"hindex":25},{},429,{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},76,93,89,80,91,{},{},{"meta":109,"data":111},{"total":110},"600",[112,224,612,748,876,1042,1281,1431,1535,1691],{"id":113,"createTime":114,"updateTime":114,"relativeEntities":115,"slug":24,"properties":116,"entityType":123,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":124,"fullTextUrl":24,"authors":125,"publicationType":184,"publisherRelationship":185,"citationCount":24,"citationInfo":24,"publishDate":221,"publishYear":222,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"968b4408-4e6e-42c6-b83d-443cbf70639d","2023-12-28T23:59:48.459+00:00",[],{"references":117,"title":119,"doi":121},{"VOID":118},"Cummings, 1993, Lancet, 341, 72, 10.1016\u002F0140-6736(93)92555-8\nD'Antonio, 1993, Clin Orthop, 296, 133, 10.1097\u002F00003086-199311000-00025\nD'Antonio, 1989, Clin Orthop, 243, 126, 10.1097\u002F00003086-198906000-00019\nDawson, 2000, Stroke, 31, 463, 10.1161\u002F01.STR.31.2.463\nDevane, 1999, Clin Orthop, 369, 59, 10.1097\u002F00003086-199912000-00007\nDowd, 2000, J Bone Joint Surg, 82-A, 1102, 10.2106\u002F00004623-200008000-00006\nDumbleton, 2002, J Arthroplasty, 17, 649, 10.1054\u002Farth.2002.33664\nFurnes, 2001, J Bone Joint Surg, 83--B, 579, 10.1302\u002F0301-620X.83B4.0830579\nGordon, 2003, Calcif Tissue Int, 72, 259\nHarris, 2003, J Arthroplasty, 18, 506, 10.1016\u002FS0883-5403(03)00153-0\nHarris, 1986, J Bone Joint Surg, 68-A, 1064, 10.2106\u002F00004623-198668070-00014\nHarris, 1987, J Bone Joint Surg, 69-A, 1140, 10.2106\u002F00004623-198769080-00005\nHui, 2003, J Bone Joint Surg, 85-A, 505, 10.2106\u002F00004623-200303000-00017\nKarrholm, 1994, J Bone Joint Surg, 76-B, 912, 10.1302\u002F0301-620X.76B6.7983118\nKesteris, 2003, J Arthroplasty, 18, 10, 10.1054\u002Farth.2003.50011\nKobayashi, 1997, J Bone Joint Surg, 79-A, 1618, 10.2106\u002F00004623-199711000-00002\nMartell, 2003, J Bone Joint Surg, 85-A, 1111, 10.2106\u002F00004623-200306000-00020\nMatthews, 2000, Biomaterials, 21, 2033, 10.1016\u002FS0142-9612(00)00089-2\nNeaton, 1992, Arch Int Med, 152, 56, 10.1001\u002Farchinte.1992.00400130082009\nOparaugo, 2001, Acta Orthop Scand, 72, 22, 10.1080\u002F000164701753606644\nOrishimo, 2003, J Bone Joint Surg, 85-A, 1095, 10.2106\u002F00004623-200306000-00018\nPedersen, 1998, J Orthop Res, 16, 557, 10.1002\u002Fjor.1100160506\nPerez, 1998, J Arthroplasty, 13, 1, 10.1016\u002FS0883-5403(98)90068-7\nSochart, 1999, Clin Orthop, 363, 135, 10.1097\u002F00003086-199906000-00018\nSychterz, 1999, J Bone Joint Surg, 81-A, 821, 10.2106\u002F00004623-199906000-00009\nSychterz, 1999, Clin Orthop, 365, 117, 10.1097\u002F00003086-199908000-00016\nWilkinson, 2002, J Arthroplasty, 17, 910, 10.1054\u002Farth.2002.34530\nWilkinson, 2003, J Bone Miner Res, 18, 1995, 10.1359\u002Fjbmr.2003.18.11.1995\nWroblewski, 1992, Clin Orthop, 285, 45, 10.1097\u002F00003086-199212000-00008",{"EN":120},"Polyethylene wear rate and osteolysis: Critical threshold versus continuous dose-response relationship",{"VOID":122},"10.1016\u002Fj.orthres.2004.11.005","PUBLICATION","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026604002530",[126,143,159,171],{"id":127,"sortIndex":128,"researcher":24,"roles":129,"affiliations":131,"properties":140},"5a4586bb-dbf3-4df6-9479-3622e5869e7c",3,[130],"AUTHOR",[132],{"id":24,"sortIndex":25,"affiliation":133,"properties":24},{"id":134,"createTime":135,"updateTime":135,"relativeEntities":136,"slug":24,"properties":137,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"be9d9bc7-ee8d-4486-9d09-6eaa15f2a4e7","2024-01-16T03:11:00.057+00:00",[],{"title":138},{"VI":139},"Academic Unit of Bone Metabolism, Division of Clinical Sciences (North), University of Sheffield, Sheffield, United Kingdom",{"title":141},{"VI":142},"Richard Eastell",{"id":144,"sortIndex":145,"researcher":24,"roles":146,"affiliations":147,"properties":156},"eb8672fd-57a6-42cd-b86b-e5dfdc1c0315",2,[130],[148],{"id":24,"sortIndex":25,"affiliation":149,"properties":24},{"id":150,"createTime":151,"updateTime":151,"relativeEntities":152,"slug":24,"properties":153,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"4efd231e-bc35-42db-853f-3c26682bf430","2023-12-28T23:59:48.493+00:00",[],{"title":154},{"VI":155},"Lower Limb Arthroplasty Unit, Department of Orthopaedics, Northern General Hospital, Herries Road, Sheffield, S5 7AU, United Kingdom",{"title":157},{"VI":158},"Ian Stockley",{"id":160,"sortIndex":25,"researcher":24,"roles":161,"affiliations":162,"properties":168},"808ca6a8-ac5b-41d1-a13a-5315f6658541",[130],[163],{"id":24,"sortIndex":25,"affiliation":164,"properties":24},{"id":150,"createTime":151,"updateTime":151,"relativeEntities":165,"slug":24,"properties":166,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":167},{"VI":155},{"title":169},{"VI":170},"J. Mark Wilkinson",{"id":172,"sortIndex":173,"researcher":24,"roles":174,"affiliations":175,"properties":181},"6ed68bb5-cd2a-4783-b56c-65e933f25607",1,[130],[176],{"id":24,"sortIndex":25,"affiliation":177,"properties":24},{"id":150,"createTime":151,"updateTime":151,"relativeEntities":178,"slug":24,"properties":179,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":180},{"VI":155},{"title":182},{"VI":183},"Andrew J. Hamer","ARTICLE",{"url":124,"publisher":186,"properties":216},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":187,"slug":10,"properties":188,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":194,"manageAffiliations":195,"indexDatabases":196,"url":96,"thumbnailPath":24,"statistic":211,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":189,"issn":190,"introduce":191,"eissn":192,"title":193},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[197,204],{"id":59,"indexDatabase":198,"url":74,"indexYears":24,"academicFieldIds":203,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":199,"label":200,"description":201,"key":70,"publicationTags":202,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":205,"url":91,"indexYears":92,"academicFieldIds":210,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":206,"label":207,"description":208,"key":88,"publicationTags":209,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":212,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":213,"totalCitation":25,"totalCitationByYear":214,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":215,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":217,"pages":219},{"VOID":218},"23",{"VOID":220},"520-525","2005-05-01",2005,false,{"id":225,"createTime":226,"updateTime":226,"relativeEntities":227,"slug":228,"properties":229,"entityType":123,"verifyStatus":244,"verifyTime":245,"verifyNote":246,"syncStatus":23,"languages":247,"translateLanguages":24,"viewCount":25,"primaryUrl":249,"fullTextUrl":24,"authors":250,"publicationType":184,"publisherRelationship":407,"citationCount":445,"citationInfo":446,"publishDate":450,"publishYear":451,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":452,"isForceReanalyzing":223},"307210cd-f71a-4f63-88a9-2f3c9a5bd8f3","2024-09-17T23:56:44.489+00:00",[],"Role-of-miR-155-in-the-regulation-of-MMP-16-expression-in-intervertebral-disc-degeneration",{"mag":230,"keywords":232,"pmc":233,"openalex":235,"abstract":237,"title":238,"pm":240,"doi":242},{"VOID":231},"2411466513",{},{"VOID":234},"5485035",{"VOID":236},"W2411466513",{},{"EN":239},"Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration",{"VOID":241},"27227700",{"VOID":243},"10.1002\u002Fjor.23313","VERIFIED","2024-09-17T23:56:44.488+00:00","Auto Verify",[248],"EN","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjor.23313",[251,272,287,309,327,348,369,384],{"id":252,"sortIndex":55,"researcher":24,"roles":253,"affiliations":254,"properties":265},"8fe08767-93c2-449b-9407-751967e11fb8",[],[255],{"id":256,"sortIndex":25,"affiliation":257,"properties":24},"25fcda27-52b0-4e73-8ec1-184d7adcfd30",{"id":258,"createTime":259,"updateTime":259,"relativeEntities":260,"slug":261,"properties":262,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7404a49b-33cd-473f-82b1-88e5ae834fd6","2024-09-17T23:56:44.525+00:00",[],"Department-of-Orthopedics-The-First-Hospital-of-China-Medical-University-155-North-Nanjing-Street-Shenyang-110001-Liaoning-China",{"title":263},{"EN":264},"Department of Orthopedics, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, Liaoning, China",{"openalex":266,"orcid":268,"title":270},{"VOID":267},"A5004884157",{"VOID":269},"https:\u002F\u002Forcid.org\u002F0000-0003-4304-7661",{"EN":271},"Maowei Yang",{"id":273,"sortIndex":145,"researcher":24,"roles":274,"affiliations":275,"properties":282},"b728b0e8-1fef-436e-8048-321ff20fdee8",[],[276],{"id":277,"sortIndex":25,"affiliation":278,"properties":24},"50bba992-b8b9-45a6-86b5-195bd925d905",{"id":258,"createTime":259,"updateTime":259,"relativeEntities":279,"slug":261,"properties":280,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":281},{"EN":264},{"openalex":283,"title":285},{"VOID":284},"A5030300902",{"EN":286},"Hong‐Zheng Meng",{"id":288,"sortIndex":289,"researcher":24,"roles":290,"affiliations":291,"properties":302},"72659e59-7047-4091-8307-5f22d60a5277",7,[],[292],{"id":293,"sortIndex":25,"affiliation":294,"properties":24},"d44c9783-e773-4a9a-bf3f-68f97a690545",{"id":295,"createTime":296,"updateTime":296,"relativeEntities":297,"slug":298,"properties":299,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7a643300-afe7-4b6d-8c19-e1ce035133c6","2024-09-17T23:56:44.515+00:00",[],"Department-of-Orthopaedics-Xijing-Hospital-Fourth-Military-Medical-University-127-Changle-Western-Road-Xi-an-710032-China",{"title":300},{"EN":301},"Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, Xi'an 710032, China",{"openalex":303,"orcid":305,"title":307},{"VOID":304},"A5090371252",{"VOID":306},"https:\u002F\u002Forcid.org\u002F0000-0002-0671-8553",{"EN":308},"Zhuojing Luo",{"id":310,"sortIndex":311,"researcher":24,"roles":312,"affiliations":313,"properties":320},"df63700a-1705-41d0-aaaf-49c5701ebb30",5,[],[314],{"id":315,"sortIndex":25,"affiliation":316,"properties":24},"8d87e247-910d-484c-85f1-ba775b759de0",{"id":295,"createTime":296,"updateTime":296,"relativeEntities":317,"slug":298,"properties":318,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":319},{"EN":301},{"openalex":321,"orcid":323,"title":325},{"VOID":322},"A5027190239",{"VOID":324},"https:\u002F\u002Forcid.org\u002F0000-0002-7752-6217",{"EN":326},"Hai‐Qiang Wang",{"id":328,"sortIndex":329,"researcher":24,"roles":330,"affiliations":331,"properties":343},"a7376453-b6fe-4f43-b94e-a49b0da8d1bb",4,[],[332],{"id":333,"sortIndex":25,"affiliation":334,"properties":24},"ce9775ab-2697-4f3f-a1fa-e61b259fc8c7",{"id":335,"createTime":336,"updateTime":337,"relativeEntities":338,"slug":339,"properties":340,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"6e1be5db-1ef3-4dcb-b600-7675a01f362d","2024-01-15T21:59:11.368+00:00","2024-09-17T23:56:44.623+00:00",[],"Institute-of-Medical-Information-Chinese-Academy-of-Medical-Sciences-Beijing-China",{"title":341},{"VI":342},"Institute of Medical Information, Chinese Academy of Medical Sciences, Beijing, China",{"openalex":344,"title":346},{"VOID":345},"A5031638453",{"EN":347},"Guan-Nan Luan",{"id":349,"sortIndex":173,"researcher":24,"roles":350,"affiliations":351,"properties":362},"c2196160-396b-4dcc-be61-71c57291346c",[],[352],{"id":353,"sortIndex":25,"affiliation":354,"properties":24},"d1b0a9e3-a7fa-4a6a-8a21-4f25e021aa04",{"id":355,"createTime":356,"updateTime":356,"relativeEntities":357,"slug":358,"properties":359,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"746dfbb7-5778-4b82-bd08-1379e4d91675","2024-09-17T23:56:44.555+00:00",[],"Department-of-Orthopaedics-Air-Force-General-Hospital-PLA-Beijing-China",{"title":360},{"EN":361},"Department of Orthopaedics, Air Force General Hospital, PLA, Beijing, China",{"openalex":363,"orcid":365,"title":367},{"VOID":364},"A5100411557",{"VOID":366},"https:\u002F\u002Forcid.org\u002F0000-0003-3224-5662",{"EN":368},"Yufei Chen",{"id":370,"sortIndex":128,"researcher":24,"roles":371,"affiliations":372,"properties":379},"0bfb7ad9-668e-4308-9281-ad0f9f6e230a",[],[373],{"id":374,"sortIndex":25,"affiliation":375,"properties":24},"427f6c0d-c5cf-4f88-803e-af99f24ad18f",{"id":355,"createTime":356,"updateTime":356,"relativeEntities":376,"slug":358,"properties":377,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":378},{"EN":361},{"openalex":380,"title":382},{"VOID":381},"A5100535819",{"EN":383},"Junjie Du",{"id":385,"sortIndex":25,"researcher":24,"roles":386,"affiliations":387,"properties":400},"cf52a6ea-362c-46ba-8638-4d16d5a14e24",[],[388,394],{"id":389,"sortIndex":25,"affiliation":390,"properties":24},"59523eff-077e-4032-997a-280aec6b2f1b",{"id":295,"createTime":296,"updateTime":296,"relativeEntities":391,"slug":298,"properties":392,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":393},{"EN":301},{"id":395,"sortIndex":173,"affiliation":396,"properties":24},"215359f6-0b7a-4fa5-96bb-ee557265c38f",{"id":258,"createTime":259,"updateTime":259,"relativeEntities":397,"slug":261,"properties":398,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":399},{"EN":264},{"openalex":401,"orcid":403,"title":405},{"VOID":402},"A5100680394",{"VOID":404},"https:\u002F\u002Forcid.org\u002F0000-0001-8618-8144",{"EN":406},"Weilin Zhang",{"url":24,"publisher":408,"properties":438},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":409,"slug":10,"properties":410,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":416,"manageAffiliations":417,"indexDatabases":418,"url":96,"thumbnailPath":24,"statistic":433,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":411,"issn":412,"introduce":413,"eissn":414,"title":415},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[419,426],{"id":59,"indexDatabase":420,"url":74,"indexYears":24,"academicFieldIds":425,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":421,"label":422,"description":423,"key":70,"publicationTags":424,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":427,"url":91,"indexYears":92,"academicFieldIds":432,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":428,"label":429,"description":430,"key":88,"publicationTags":431,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":434,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":435,"totalCitation":25,"totalCitationByYear":436,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":437,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":439,"pages":441,"issue":443},{"VOID":440},"35",{"VOID":442},"1323-1334",{"VOID":444},"6",45,{"total":445,"publishYear":24,"statisticByYear":447},{"2017":128,"2018":128,"2019":55,"2020":448,"2021":45,"2022":449,"2023":128,"2024":145},11,9,"2017-06-01",2017,[453,457,461,465,469,473,477,481,485,489,493,497,501,505,509,513,517,521,525,529,533,537,541,545,549,553,557,561,565,569,573,577,581,585,589,593,597,601,605,608],{"id":24,"text":454,"url":24,"identifiers":455},"Waddell, 1996, Low back pain: a twentieth century health care enigma, Spine, 21, 2820, 10.1097\u002F00007632-199612150-00002",{"doi":456},"10.1097\u002F00007632-199612150-00002",{"id":24,"text":458,"url":24,"identifiers":459},"Maniadakis, 2000, The economic burden of back pain in the UK, Pain, 84, 95, 10.1016\u002FS0304-3959(99)00187-6",{"doi":460},"10.1016\u002FS0304-3959(99)00187-6",{"id":24,"text":462,"url":24,"identifiers":463},"Andersson, 1999, Epidemiological features of chronic low-back pain, Lancet, 354, 581, 10.1016\u002FS0140-6736(99)01312-4",{"doi":464},"10.1016\u002FS0140-6736(99)01312-4",{"id":24,"text":466,"url":24,"identifiers":467},"Urban, 2003, Degeneration of the intervertebral disc, Arthritis Res Ther, 5, 120, 10.1186\u002Far629",{"doi":468},"10.1186\u002Far629",{"id":24,"text":470,"url":24,"identifiers":471},"Eyre, 1977, Quantitative analysis of types I and II collagens in human intervertebral discs at various ages, Biochim Biophys Acta, 492, 29, 10.1016\u002F0005-2795(77)90211-2",{"doi":472},"10.1016\u002F0005-2795(77)90211-2",{"id":24,"text":474,"url":24,"identifiers":475},"Urban, 1979, Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues, Biorheology, 16, 447, 10.3233\u002FBIR-1979-16609",{"doi":476},"10.3233\u002FBIR-1979-16609",{"id":24,"text":478,"url":24,"identifiers":479},"Weiler, 2002, 2002 SSE award competition in basic science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption, Eur Spine J, 11, 308, 10.1007\u002Fs00586-002-0472-0",{"doi":480},"10.1007\u002Fs00586-002-0472-0",{"id":24,"text":482,"url":24,"identifiers":483},"d'Ortho, 1997, Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases, Eur J Biochem, 250, 751, 10.1111\u002Fj.1432-1033.1997.00751.x",{"doi":484},"10.1111\u002Fj.1432-1033.1997.00751.x",{"id":24,"text":486,"url":24,"identifiers":487},"Jung, 2009, Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation, Cell Tissue Res, 336, 79, 10.1007\u002Fs00441-009-0755-4",{"doi":488},"10.1007\u002Fs00441-009-0755-4",{"id":24,"text":490,"url":24,"identifiers":491},"Roberts, 2000, Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc, Spine, 25, 3005, 10.1097\u002F00007632-200012010-00007",{"doi":492},"10.1097\u002F00007632-200012010-00007",{"id":24,"text":494,"url":24,"identifiers":495},"Rutges, 2008, Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels, J Pathol, 214, 523, 10.1002\u002Fpath.2317",{"doi":496},"10.1002\u002Fpath.2317",{"id":24,"text":498,"url":24,"identifiers":499},"Yurube, 2012, Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration, Arthritis Res Ther, 14, R51, 10.1186\u002Far3764",{"doi":500},"10.1186\u002Far3764",{"id":24,"text":502,"url":24,"identifiers":503},"Rastogi, 2013, MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc, Arthritis Res Ther, 15, R57, 10.1186\u002Far4224",{"doi":504},"10.1186\u002Far4224",{"id":24,"text":506,"url":24,"identifiers":507},"Worm, 2009, Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c\u002Febp Beta and down-regulation of G-CSF, Nucl Acids Res, 37, 5784, 10.1093\u002Fnar\u002Fgkp577",{"doi":508},"10.1093\u002Fnar\u002Fgkp577",{"id":24,"text":510,"url":24,"identifiers":511},"Teng, 2009, Shhh! Silencing by microRNA-155, Philos Trans R Soc Lond B Biol Sci, 364, 631, 10.1098\u002Frstb.2008.0209",{"doi":512},"10.1098\u002Frstb.2008.0209",{"id":24,"text":514,"url":24,"identifiers":515},"Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016\u002FS0092-8674(04)00045-5",{"doi":516},"10.1016\u002FS0092-8674(04)00045-5",{"id":24,"text":518,"url":24,"identifiers":519},"Wang, 2011, Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3, J Pathol, 225, 232, 10.1002\u002Fpath.2931",{"doi":520},"10.1002\u002Fpath.2931",{"id":24,"text":522,"url":24,"identifiers":523},"Clowry, 2000, The successful use of fentanyl\u002Ffluanisone (‘Hypnorm’) as an anaesthetic for intracranial surgery in neonatal rats, Lab Anim, 34, 260, 10.1258\u002F002367700780384771",{"doi":524},"10.1258\u002F002367700780384771",{"id":24,"text":526,"url":24,"identifiers":527},"Masuda, 2006, Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model, Spine, 31, 742, 10.1097\u002F01.brs.0000206358.66412.7b",{"doi":528},"10.1097\u002F01.brs.0000206358.66412.7b",{"id":24,"text":530,"url":24,"identifiers":531},"Walsh, 2004, In vivo growth factor treatment of degenerated intervertebral discs, Spine, 29, 156, 10.1097\u002F01.BRS.0000107231.67854.9F",{"doi":532},"10.1097\u002F01.BRS.0000107231.67854.9F",{"id":24,"text":534,"url":24,"identifiers":535},"Nomura, 2001, Nucleus pulposus allograft retards intervertebral disc degeneration, Clin Orthop Relat Res, 389, 94, 10.1097\u002F00003086-200108000-00015",{"doi":536},"10.1097\u002F00003086-200108000-00015",{"id":24,"text":538,"url":24,"identifiers":539},"Sive, 2002, Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs, Mol Pathol, 55, 91, 10.1136\u002Fmp.55.2.91",{"doi":540},"10.1136\u002Fmp.55.2.91",{"id":24,"text":542,"url":24,"identifiers":543},"Obernosterer, 2007, Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections, Nat Protoc, 2, 1508, 10.1038\u002Fnprot.2007.153",{"doi":544},"10.1038\u002Fnprot.2007.153",{"id":24,"text":546,"url":24,"identifiers":547},"Silahtaroglu, 2007, Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification, Nat Protoc, 2, 2520, 10.1038\u002Fnprot.2007.313",{"doi":548},"10.1038\u002Fnprot.2007.313",{"id":24,"text":550,"url":24,"identifiers":551},"Nuovo, 2009, A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets, Nat Protoc, 4, 107, 10.1038\u002Fnprot.2008.215",{"doi":552},"10.1038\u002Fnprot.2008.215",{"id":24,"text":554,"url":24,"identifiers":555},"Meng, 2015, Advanced glycation end products affect osteoblast proliferation and function by modulating autophagy via the receptor of advanced glycation end products\u002FRaf protein\u002Fmitogen-activated protein kinase\u002Fextracellular signal-regulated kinase kinase\u002Fextracellular signal-regulated kinase (RAGE\u002FRaf\u002FMEK\u002FERK) pathway, J Biol Chem, 290, 28189, 10.1074\u002Fjbc.M115.669499",{"doi":556},"10.1074\u002Fjbc.M115.669499",{"id":24,"text":558,"url":24,"identifiers":559},"Lotz, 1998, Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study, Spine, 23, 2493, 10.1097\u002F00007632-199812010-00004",{"doi":560},"10.1097\u002F00007632-199812010-00004",{"id":24,"text":562,"url":24,"identifiers":563},"Yang, 2009, Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse, J Pathol, 218, 113, 10.1002\u002Fpath.2519",{"doi":564},"10.1002\u002Fpath.2519",{"id":24,"text":566,"url":24,"identifiers":567},"Haughton, 2004, Medical imaging of intervertebral disc degeneration: current status of imaging, Spine, 29, 2751, 10.1097\u002F01.brs.0000148475.04738.73",{"doi":568},"10.1097\u002F01.brs.0000148475.04738.73",{"id":24,"text":570,"url":24,"identifiers":571},"Freemont, 2002, Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy, J Pathol, 196, 374, 10.1002\u002Fpath.1050",{"doi":572},"10.1002\u002Fpath.1050",{"id":24,"text":574,"url":24,"identifiers":575},"Bail, 2010, Differential regulation of microRNA stability, RNA, 16, 1032, 10.1261\u002Frna.1851510",{"doi":576},"10.1261\u002Frna.1851510",{"id":24,"text":578,"url":24,"identifiers":579},"Raj, 2008, Intervertebral disc: anatomy-physiology-pathophysiology-treatment, Pain Pract, 8, 18, 10.1111\u002Fj.1533-2500.2007.00171.x",{"doi":580},"10.1111\u002Fj.1533-2500.2007.00171.x",{"id":24,"text":582,"url":24,"identifiers":583},"Eser, 2011, Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients, Genet Mol Res, 10, 1923, 10.4238\u002Fvol10-3gmr1222",{"doi":584},"10.4238\u002Fvol10-3gmr1222",{"id":24,"text":586,"url":24,"identifiers":587},"Lu, 2004, Safe two-plasmid production for the first clinical lentivirus vector that achieves >99% transduction in primary cells using a one-step protocol, J Gene Med, 6, 963, 10.1002\u002Fjgm.593",{"doi":588},"10.1002\u002Fjgm.593",{"id":24,"text":590,"url":24,"identifiers":591},"Davis, 2004, ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells, Blood, 104, 364, 10.1182\u002Fblood-2003-07-2363",{"doi":592},"10.1182\u002Fblood-2003-07-2363",{"id":24,"text":594,"url":24,"identifiers":595},"Reichenbach, 2010, Germ-line transmission of lentiviral PGK-EGFP integrants in transgenic cattle: new perspectives for experimental embryology, Transgenic Res, 19, 549, 10.1007\u002Fs11248-009-9333-5",{"doi":596},"10.1007\u002Fs11248-009-9333-5",{"id":24,"text":598,"url":24,"identifiers":599},"Deng, 2015, Expression profiles of MMP-1 and TIMP-1 in lumbar intervertebral disc degeneration, Genet Mol Res, 14, 19080, 10.4238\u002F2015.December.29.16",{"doi":600},"10.4238\u002F2015.December.29.16",{"id":24,"text":602,"url":24,"identifiers":603},"Vo, 2013, Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration, Spine J, 13, 331, 10.1016\u002Fj.spinee.2012.02.027",{"doi":604},"10.1016\u002Fj.spinee.2012.02.027",{"id":24,"text":606,"url":24,"identifiers":607},"David, 2011, Impact of changes in extracellular matrix in the lumbar degenerative disc, J Med Life, 4, 269",{},{"id":24,"text":609,"url":24,"identifiers":610},"Malfait, 2002, Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage, J Biol Chem, 277, 22201, 10.1074\u002Fjbc.M200431200",{"doi":611},"10.1074\u002Fjbc.M200431200",{"id":613,"createTime":614,"updateTime":615,"relativeEntities":616,"slug":617,"properties":618,"entityType":123,"verifyStatus":244,"verifyTime":615,"verifyNote":246,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":623,"fullTextUrl":24,"authors":624,"publicationType":184,"publisherRelationship":712,"citationCount":24,"citationInfo":24,"publishDate":747,"publishYear":222,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"88fb85e4-0825-44ae-9cc0-526fa0b1af39","2024-02-10T08:33:31.379+00:00","2025-01-16T23:54:21.419+00:00",[],"Cellular-basis-for-age-related-changes-in-fracture-repair",{"title":619,"doi":621},{"EN":620},"Cellular basis for age-related changes in fracture repair",{"VOID":622},"10.1016\u002Fj.orthres.2005.04.003","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS073602660500104X",[625,640,652,664,676,688,700],{"id":626,"sortIndex":329,"researcher":24,"roles":627,"affiliations":628,"properties":637},"9ab94c40-6c06-472f-8233-56e5d21a0096",[130],[629],{"id":24,"sortIndex":25,"affiliation":630,"properties":24},{"id":631,"createTime":632,"updateTime":632,"relativeEntities":633,"slug":24,"properties":634,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"fcbea7b7-9be2-4af8-85d2-fea750eae65b","2024-02-10T08:33:31.435+00:00",[],{"title":635},{"VI":636},"Department of Orthopaedic Surgery, San Francisco General Hospital, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA",{"title":638},{"VI":639},"Kathy Tsui",{"id":641,"sortIndex":128,"researcher":24,"roles":642,"affiliations":643,"properties":649},"4b0d7b57-b73a-4409-93b3-d914d7ddb5e9",[130],[644],{"id":24,"sortIndex":25,"affiliation":645,"properties":24},{"id":631,"createTime":632,"updateTime":632,"relativeEntities":646,"slug":24,"properties":647,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":648},{"VI":636},{"title":650},{"VI":651},"Erik Hansen",{"id":653,"sortIndex":173,"researcher":24,"roles":654,"affiliations":655,"properties":661},"1aad7804-61f2-4a39-8221-626a5ab3f614",[130],[656],{"id":24,"sortIndex":25,"affiliation":657,"properties":24},{"id":631,"createTime":632,"updateTime":632,"relativeEntities":658,"slug":24,"properties":659,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":660},{"VI":636},{"title":662},{"VI":663},"Theodore Miclau",{"id":665,"sortIndex":25,"researcher":24,"roles":666,"affiliations":667,"properties":673},"97707510-3d3a-4d9f-b5ca-742863011d77",[130],[668],{"id":24,"sortIndex":25,"affiliation":669,"properties":24},{"id":631,"createTime":632,"updateTime":632,"relativeEntities":670,"slug":24,"properties":671,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":672},{"VI":636},{"title":674},{"VI":675},"Chuanyong Lu",{"id":677,"sortIndex":145,"researcher":24,"roles":678,"affiliations":679,"properties":685},"3a0327b4-d7b5-426a-90df-4246af37a536",[130],[680],{"id":24,"sortIndex":25,"affiliation":681,"properties":24},{"id":631,"createTime":632,"updateTime":632,"relativeEntities":682,"slug":24,"properties":683,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":684},{"VI":636},{"title":686},{"VI":687},"Diane Hu",{"id":689,"sortIndex":311,"researcher":24,"roles":690,"affiliations":691,"properties":697},"0a3250ee-b786-4deb-9f56-a26e884e38cb",[130],[692],{"id":24,"sortIndex":25,"affiliation":693,"properties":24},{"id":631,"createTime":632,"updateTime":632,"relativeEntities":694,"slug":24,"properties":695,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":696},{"VI":636},{"title":698},{"VI":699},"Christian Puttlitz",{"id":701,"sortIndex":55,"researcher":24,"roles":702,"affiliations":703,"properties":709},"6348a2f9-078f-45f8-bc08-4cbf4a06f375",[130],[704],{"id":24,"sortIndex":25,"affiliation":705,"properties":24},{"id":631,"createTime":632,"updateTime":632,"relativeEntities":706,"slug":24,"properties":707,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":708},{"VI":636},{"title":710},{"VI":711},"Ralph S. Marcucio",{"url":623,"publisher":713,"properties":743},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":714,"slug":10,"properties":715,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":721,"manageAffiliations":722,"indexDatabases":723,"url":96,"thumbnailPath":24,"statistic":738,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":716,"issn":717,"introduce":718,"eissn":719,"title":720},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[724,731],{"id":59,"indexDatabase":725,"url":74,"indexYears":24,"academicFieldIds":730,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":726,"label":727,"description":728,"key":70,"publicationTags":729,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":732,"url":91,"indexYears":92,"academicFieldIds":737,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":733,"label":734,"description":735,"key":88,"publicationTags":736,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":739,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":740,"totalCitation":25,"totalCitationByYear":741,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":742,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":744,"pages":745},{"VOID":218},{"VOID":746},"1300-1307","2005-11-01",{"id":749,"createTime":750,"updateTime":751,"relativeEntities":752,"slug":753,"properties":754,"entityType":123,"verifyStatus":244,"verifyTime":751,"verifyNote":246,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":763,"fullTextUrl":24,"authors":764,"publicationType":184,"publisherRelationship":838,"citationCount":24,"citationInfo":24,"publishDate":874,"publishYear":875,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"9ea1e46c-c151-4417-a922-177cf3d447e9","2023-12-13T01:40:01.688+00:00","2025-02-06T23:52:44.008+00:00",[],"Effects-of-hydroxyapatite-participate-debris-on-the-production-of-cytokines-and-proteases-in-human-fibroblasts",{"references":755,"abstract":757,"title":759,"doi":761},{"VOID":756},"BauerTW TaylorSK JiangM MedendorpSV. An indirect comparison of third‐body wear in retrieved hydroxyapatite‐coated porous and cemented femoral components.Clin Orthop1994;11–8.\nElaine TA, 1996, Increased levels of tumor necrosis factor‐alpha and interleukin‐6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles, J Bone Joint Surg Am, 78, 1181, 10.2106\u002F00004623-199608000-00008\nBloebaumRD BeeksD DorrLD SavoryCG DuPontJA HofmannAA. Complications with hydroxyapatite particulate separation in total hip arthoplasty.Clin Orthop1994;19–26.\n10.1016\u002FS0883-5403(09)80013-2\nBloebaumRD ZouL BachusKN SheaKG HofmannAA DunnHK. Analysis of particles in acetabular components from patients with osteolysis.Clin Orthop1997;109–18.\n10.1007\u002FBF02555703\nCapello WN, 1994, Hydroxyapatite in total hip arthroplasty: five‐year clinical experience, Orthopedics, 17, 781, 10.3928\u002F0147-7447-19940901-12\n10.2106\u002F00004623-199707000-00008\n10.1007\u002FBF01665905\n10.1002\u002Fart.1780270610\n10.1016\u002FS1063-4584(97)80009-X\n10.1002\u002Fart.1780241102\n10.3181\u002F00379727-173-41628\n10.1016\u002F0014-4827(85)90152-1\nCheung HS, 1988, Mechanisms of connective tissue damage by crystals containing calcium, Rheum Dis Clin North Am, 14, 365, 10.1016\u002FS0889-857X(21)00970-4\n10.1002\u002Fart.1780270610\n10.1016\u002F0003-2697(87)90021-2\n10.1016\u002F0883-5403(94)90117-1\nDavisL DibnerM BatteyJ.Basic Methods Mol Biol1986;143–6.\n10.1007\u002FBF02405384\n10.1016\u002F0003-2697(83)90418-9\nGeesink R, 1997, Eight years results of HA‐coated primary total hip replacement, Acta Orthop Belg, 63, 72\n10.1302\u002F0301-620X.77B4.7615595\n10.1002\u002Fjbmr.5650081003\n10.1074\u002Fjbc.271.18.10984\nHalversonPB CheungHS JohnsonR StruveJ. Simultaneous occurrence of calcium pyrophosphate dihydrate and basic calcium phosphate (hydroxyapatite) crystals in a knee.Clin Orthop1990;162–5.\n10.1016\u002F0049-0172(84)90007-6\n10.1002\u002Fart.1780330312\n10.1007\u002FBF00572908\nJaDas CapelloWN ManleyMT FeinbergJ. Hydroxyapatite coated implants. Total hip arthroplasty in the young patient and patients with avascular necrosis.Clin Orthop1997;124–38.\n10.2106\u002F00004623-199612000-00018\n10.2106\u002F00004623-199306000-00005\n10.2106\u002F00004623-199509000-00002\n10.1002\u002Fjor.1100140317\n10.1002\u002Fjcp.1041530118\n10.1302\u002F0301-620X.80B2.8316\nRothman RH, 1996, Hydroxy‐apatite‐coated femoral stems. A matched‐pair analysis of coated and uncoated implants, J Bone Joint Surg Am, 78, 319, 10.2106\u002F00004623-199603000-00001\nShanbhaag AS, 1994, Composition and morphology of wear debris in failed uncemented total hip replacement, J Bone Joint Surg Br, 76, 60, 10.1302\u002F0301-620X.76B1.8300684\n10.1177\u002F00220345940730050801\nToth J, 1995, Mechanical and biological characterization of calcium phosphates for use as biomaterials, Encyclopedic handbook of biomaterials and bioengineering, 2, 1465\n10.1002\u002Fjab.770020106\n10.1093\u002Fnar\u002F13.7.2485\nVan De Motter R, 1999, Adherent endotoxin exists on orthopaedic implant surfaces and wear particles, Trans Orthop Res Soc, 24\nWeinbergJ. Endotoxin contamination and in vitro monocyte‐macrophage function: methods of detecting detoxyfying and eliminating endotoxin.Methods Studying Mononuclear Phagocytes1981;139–54.",{"EN":758},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Cytokines and proteases are secreted by fibroblasts in response to particulate wear debris, and these proteins are felt to play an important role in the development of osteolysis and implant loosening. Although metallic and polyethlyene debris have been studied extensively, little is known about the cellular responses to hydroxyapatite, despite the wide clinical use of these materials. Therefore, the effects of hydroxyapatite (HA) and hydroxyapatite\u002Fβ‐tricalciumphosphate (HA\u002FTCP) on cellular proliferation, cytokine gene expression and protein secretion, protease synthesis, and gelatinolytic activity were investigated in human fibroblasts.\u003C\u002Fjats:p>\u003Cjats:p>HA and HA\u002FTCP particles were synthesized, and their effects were compared to the responses elicited by titanium and cobalt chromium. Sample characterization by scanning electron microscopy and Coulter Counter demonstrated that the materials had a mean particle size of less than 10 μm, and all of the particles were compared using the same concentration ranges.\u003C\u002Fjats:p>\u003Cjats:p>Aliquots of particle suspensions were added to human fibroblasts maintained in tissue culture, and dose‐response and time‐course experiments were performed. Effects of the particles on fibroblast proliferation were assessed, and alterations in cytokine levels were determined by specific enzyme linked immunosorbent assays (ELISA). Cytokines that were evaluated included inter‐leukin‐1 (IL‐β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α), all of which have been demonstrated to enhance bone resorption and are associated with osteolysis and implant loosening. Gene expression was determined using Northern blot analysis with cytokine‐specific probes, while secretion of the proteases collagenase and stromelysin was determined by Western blot analysis. Functional gelatinolytic assay was assessed using zymogram gels.\u003C\u002Fjats:p>\u003Cjats:p>The particles were evaluated in a concentration range from 0.000021 to 0.021 vol%. All of the particles produced increases in cellular proliferation up to 0.0021 vol%, with the largest increases being seen at 0.021 vol% with HA\u002FTCP and titanium. At the highest concentration, both cobalt chromium and HA samples decreased cellular proliferation relative to lower doses, possibly representing cytotoxicity.\u003C\u002Fjats:p>\u003Cjats:p>Hydroxyapatite particles yielded a 30‐fold increase in interleukin‐6 secretion compared to unstimulated controls, which was also greater than three times the levels produced by cobalt chromium, titanium, or HA\u002FTCP. HA particles also tripled the secretion of IL‐1β at 0.00021 vol%, and doubled TNF‐α secretion at 0.021 vol%. Addition of conditioned media prepared by incubation of the particles in culture medium in the absence of cells did not alter the secretion of any of the cytokines. Northern blot analysis using IL‐6 probes also demonstrated strong increases with HA compared to the other materials, suggesting that the action of the HA particles was at the level of transcription. Secretion of the protease collagenase was increased by all of the samples including HA when compared to unstimulated controls. Stromelysin secretion into the culture medium was decreased by cobalt chromium, but increased by titanium, HA, and HA\u002FTCP. All of the particles including HA increased the gelatinolytic activity of the fibroblasts.\u003C\u002Fjats:p>\u003Cjats:p>These findings demonstrate that HA and HA\u002FTCP particles are capable of stimulating the expression and secretion of cytokines and proteases that enhance bone resorption, and suggest that particulate debris from implants using these coatings may also increase osteolysis and loosening. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.\u003C\u002Fjats:p>",{"EN":760},"Effects of hydroxyapatite participate debris on the production of cytokines and proteases in human fibroblasts",{"VOID":762},"10.1016\u002Fs0736-0266(00)00061-9","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026600000619",[765,790,802,814,826],{"id":766,"sortIndex":329,"researcher":24,"roles":767,"affiliations":768,"properties":787},"083d40cf-e1be-47d4-b2ff-5db41a8a552f",[130],[769,779],{"id":770,"sortIndex":173,"affiliation":771,"properties":778},"a234c7c6-f50d-4d15-9c96-12d4fa6999de",{"id":772,"createTime":773,"updateTime":773,"relativeEntities":774,"slug":24,"properties":775,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"3f0bfa43-ad46-4c17-83bb-2206a2686070","2023-12-13T01:39:51.836+00:00",[],{"title":776},{"VI":777},"Concord Research Center, Concord, OH, USA",{},{"id":24,"sortIndex":25,"affiliation":780,"properties":24},{"id":781,"createTime":782,"updateTime":782,"relativeEntities":783,"slug":24,"properties":784,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"c557d24c-609b-43dd-aa71-8805500012a0","2023-12-13T01:39:51.785+00:00",[],{"title":785},{"VI":786},"Department of Orthopaedic Surgery, Medical College of Wisconsin, FMLH East, 9200 West Wisconsin Avenue, Milwaukee, WI, USA",{"title":788},{"VI":789},"Kevin E. Crosby",{"id":791,"sortIndex":145,"researcher":24,"roles":792,"affiliations":793,"properties":799},"04db0e55-3aec-451e-bf53-b004a7787b26",[130],[794],{"id":24,"sortIndex":25,"affiliation":795,"properties":24},{"id":781,"createTime":782,"updateTime":782,"relativeEntities":796,"slug":24,"properties":797,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":798},{"VI":786},{"title":800},{"VI":801},"Cary T. Stelloh",{"id":803,"sortIndex":128,"researcher":24,"roles":804,"affiliations":805,"properties":811},"6a370832-fbf0-444a-8e46-25ffbb6d3222",[130],[806],{"id":24,"sortIndex":25,"affiliation":807,"properties":24},{"id":781,"createTime":782,"updateTime":782,"relativeEntities":808,"slug":24,"properties":809,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":810},{"VI":786},{"title":812},{"VI":813},"Jeffrey M. Toth",{"id":815,"sortIndex":25,"researcher":24,"roles":816,"affiliations":817,"properties":823},"b5582149-88e2-4c0c-a4b5-a9bb11d96aaa",[130],[818],{"id":24,"sortIndex":25,"affiliation":819,"properties":24},{"id":781,"createTime":782,"updateTime":782,"relativeEntities":820,"slug":24,"properties":821,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":822},{"VI":786},{"title":824},{"VI":825},"James T. Ninomiya",{"id":827,"sortIndex":173,"researcher":24,"roles":828,"affiliations":829,"properties":835},"4fade1dd-96dc-4de8-be37-a9823384f5c0",[130],[830],{"id":24,"sortIndex":25,"affiliation":831,"properties":24},{"id":781,"createTime":782,"updateTime":782,"relativeEntities":832,"slug":24,"properties":833,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":834},{"VI":786},{"title":836},{"VI":837},"Janine A. Struve",{"url":763,"publisher":839,"properties":869},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":840,"slug":10,"properties":841,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":847,"manageAffiliations":848,"indexDatabases":849,"url":96,"thumbnailPath":24,"statistic":864,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":842,"issn":843,"introduce":844,"eissn":845,"title":846},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[850,857],{"id":59,"indexDatabase":851,"url":74,"indexYears":24,"academicFieldIds":856,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":852,"label":853,"description":854,"key":70,"publicationTags":855,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":858,"url":91,"indexYears":92,"academicFieldIds":863,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":859,"label":860,"description":861,"key":88,"publicationTags":862,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":865,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":866,"totalCitation":25,"totalCitationByYear":867,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":868,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":870,"pages":872},{"VOID":871},"19",{"VOID":873},"621-628","2001-07-01",2001,{"id":877,"createTime":878,"updateTime":879,"relativeEntities":880,"slug":881,"properties":882,"entityType":123,"verifyStatus":244,"verifyTime":879,"verifyNote":246,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":891,"fullTextUrl":24,"authors":892,"publicationType":184,"publisherRelationship":1004,"citationCount":24,"citationInfo":24,"publishDate":1040,"publishYear":1041,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"6d0f6937-eb32-41b9-b071-7db70c811c6a","2023-12-06T15:55:58.885+00:00","2025-02-18T23:50:51.671+00:00",[],"Smad6-is-induced-by-BMP-2-and-modulates-chondrocyte-differentiation",{"references":883,"abstract":885,"title":887,"doi":889},{"VOID":884},"10.1006\u002Fbbrc.1998.9170\nBallock RT, 2000, Thyroid hormone regulates terminal differentiation of growth plate chondrocytes through local induction of bone morphogenetic proteins, Trans Orthop Res Soc, 25, 160\n10.1359\u002Fjbmr.1999.14.11.1805\n10.1210\u002Fendo.138.7.5125\n10.1097\u002F00003086-199810001-00013\n10.1002\u002Fjbmr.5650100310\n10.1002\u002F(SICI)1097-4644(20000615)77:4\u003C678::AID-JCB15>3.0.CO;2-P\n10.1210\u002Fendo.141.12.7848\n10.1006\u002Fbcmd.2002.0487\n10.1038\u002F72835\n10.1089\u002F108729000421448\n10.1002\u002Fjor.1100160212\n10.1359\u002Fjbmr.1999.14.4.475\n10.1002\u002F1097-4644(20010501)81:2\u003C284::AID-JCB1043>3.0.CO;2-D\n10.1083\u002Fjcb.200106023\n10.1016\u002FS0092-8674(00)80303-7\n10.1038\u002F39355\n10.1074\u002Fjbc.275.9.6075\n10.1074\u002Fjbc.274.19.13637\n10.1074\u002Fjbc.C000580200\n10.1089\u002Foli.1.1996.6.169\n10.1006\u002Fdbio.1998.9181\n10.1002\u002Fmrd.10202\n10.1074\u002Fjbc.273.39.25364\n10.1007\u002Fs003350010032\n10.1006\u002Fbbrc.1998.8200\n10.1359\u002Fjbmr.1998.13.10.1521\n10.1126\u002Fscience.273.5275.613\n10.1083\u002Fjcb.148.4.679\n10.1016\u002FS0092-8674(00)81556-1\nWrana JL, 1992, TGF‐beta signals through a heteromeric protein kinase receptor complex, Cell, 71, 1002, 10.1016\u002F0092-8674(92)90395-S\n10.1006\u002Fdbio.1999.9419\n10.1002\u002Fjbm.1289\n10.1073\u002Fpnas.98.3.974",{"EN":886},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>BMPs regulate cartilage differentiation and have been approved for clinical use as stimulators of bone repair. BMP signaling is complex and there are multiple potential points of regulation, including modulation of Smad signaling, which is inhibited by both Smad6 and Smad7. In the current manuscript we assessed the expression and biological function of Smad6 during chondrocyte differentiation. We found that the induction of chondrocyte differentiation by BMP‐2 in chicken sternal embryonic chondrocytes was accompanied by a marked increase in Smad6 mRNA and protein levels. A morpholino antisense oligonucleotide complementary to \u003Cjats:italic>Smad6\u003C\u002Fjats:italic> reduced the expression of Smad6 protein and enhanced the stimulatory effect of BMP‐2 on both \u003Cjats:italic>colX\u003C\u002Fjats:italic> and alkaline phosphatase activity. In contrast, over‐expression of Smad6 blocked BMP‐2 mediated induction of the type X collagen promoter, b2‐640 Luc. Therefore, expression studies as well as gain and loss of function experiments suggest that Smad6 participates in an important negative feedback loop whereby BMP‐2 mediated effects on chondrocyte differentiation are reduced by induction of \u003Cjats:italic>Smad6\u003C\u002Fjats:italic>. Additional studies are required to determine the extent to which this pathway participates in pathologic processes involving cartilage. © 2003 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.\u003C\u002Fjats:p>",{"EN":888},"Smad6 is induced by BMP‐2 and modulates chondrocyte differentiation",{"VOID":890},"10.1016\u002Fs0736-0266(03)00008-1","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026603000081",[893,908,920,932,944,956,968,980,992],{"id":894,"sortIndex":45,"researcher":24,"roles":895,"affiliations":896,"properties":905},"e03fa3f5-3240-4cbf-8733-0864b925b21d",[130],[897],{"id":24,"sortIndex":25,"affiliation":898,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":901,"slug":24,"properties":902,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"cfbe17bf-8eb0-4af6-8b57-a85598b2a099","2023-12-06T15:56:04.518+00:00",[],{"title":903},{"VI":904},"Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA",{"title":906},{"VI":907},"Regis J O’Keefe",{"id":909,"sortIndex":329,"researcher":24,"roles":910,"affiliations":911,"properties":917},"b57e2e7f-537e-410e-980c-ad6c54df1552",[130],[912],{"id":24,"sortIndex":25,"affiliation":913,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":914,"slug":24,"properties":915,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":916},{"VI":904},{"title":918},{"VI":919},"Hicham Drissi",{"id":921,"sortIndex":145,"researcher":24,"roles":922,"affiliations":923,"properties":929},"2f25565a-9be6-494c-a015-1f75f1467d24",[130],[924],{"id":24,"sortIndex":25,"affiliation":925,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":926,"slug":24,"properties":927,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":928},{"VI":904},{"title":930},{"VI":931},"Edward M Schwarz",{"id":933,"sortIndex":289,"researcher":24,"roles":934,"affiliations":935,"properties":941},"af088660-1a88-4d66-a4c3-dd02bcfab802",[130],[936],{"id":24,"sortIndex":25,"affiliation":937,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":938,"slug":24,"properties":939,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":940},{"VI":904},{"title":942},{"VI":943},"Michael J Zuscik",{"id":945,"sortIndex":25,"researcher":24,"roles":946,"affiliations":947,"properties":953},"d3fa8edf-8199-4dc7-b406-60f7d7b1d092",[130],[948],{"id":24,"sortIndex":25,"affiliation":949,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":950,"slug":24,"properties":951,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":952},{"VI":904},{"title":954},{"VI":955},"Xeufeng Li",{"id":957,"sortIndex":311,"researcher":24,"roles":958,"affiliations":959,"properties":965},"d2213fdc-2c1d-4c7a-af67-0ce3a1bca11d",[130],[960],{"id":24,"sortIndex":25,"affiliation":961,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":962,"slug":24,"properties":963,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":964},{"VI":904},{"title":966},{"VI":967},"J.Edward Puzas",{"id":969,"sortIndex":128,"researcher":24,"roles":970,"affiliations":971,"properties":977},"96fcd912-2c59-4d36-a18b-4cb4d4e3ffa2",[130],[972],{"id":24,"sortIndex":25,"affiliation":973,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":974,"slug":24,"properties":975,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":976},{"VI":904},{"title":978},{"VI":979},"Xinping Zhang",{"id":981,"sortIndex":55,"researcher":24,"roles":982,"affiliations":983,"properties":989},"690b2fec-3487-4adb-a480-5ad78ca493bb",[130],[984],{"id":24,"sortIndex":25,"affiliation":985,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":986,"slug":24,"properties":987,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":988},{"VI":904},{"title":990},{"VI":991},"Randy N Rosier",{"id":993,"sortIndex":173,"researcher":24,"roles":994,"affiliations":995,"properties":1001},"a3906bef-39ba-49a0-a965-2263e83edf27",[130],[996],{"id":24,"sortIndex":25,"affiliation":997,"properties":24},{"id":899,"createTime":900,"updateTime":900,"relativeEntities":998,"slug":24,"properties":999,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1000},{"VI":904},{"title":1002},{"VI":1003},"Andreia M Ionescu",{"url":891,"publisher":1005,"properties":1035},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1006,"slug":10,"properties":1007,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1013,"manageAffiliations":1014,"indexDatabases":1015,"url":96,"thumbnailPath":24,"statistic":1030,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1008,"issn":1009,"introduce":1010,"eissn":1011,"title":1012},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1016,1023],{"id":59,"indexDatabase":1017,"url":74,"indexYears":24,"academicFieldIds":1022,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1018,"label":1019,"description":1020,"key":70,"publicationTags":1021,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":1024,"url":91,"indexYears":92,"academicFieldIds":1029,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1025,"label":1026,"description":1027,"key":88,"publicationTags":1028,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":1031,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":1032,"totalCitation":25,"totalCitationByYear":1033,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":1034,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":1036,"pages":1038},{"VOID":1037},"21",{"VOID":1039},"908-913","2003-09-01",2003,{"id":1043,"createTime":1044,"updateTime":1045,"relativeEntities":1046,"slug":1047,"properties":1048,"entityType":123,"verifyStatus":244,"verifyTime":1057,"verifyNote":246,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":1058,"fullTextUrl":24,"authors":1059,"publicationType":184,"publisherRelationship":1150,"citationCount":1186,"citationInfo":1187,"publishDate":1190,"publishYear":1188,"citationAnalyzeStatus":23,"lastCitationAnalyze":1191,"indexDatabases":24,"openAccess":24,"references":1192,"isForceReanalyzing":223},"c36d9c3b-6dc5-4951-8084-333e9e1f5171","2023-12-29T11:07:38.499+00:00","2026-04-11T23:35:19.211+00:00",[],"A-quantitative-method-to-measure-maximal-workspace-of-the-trapeziometacarpal-joint-normal-model-development",{"abstract":1049,"title":1051,"doi":1053,"gsPaper":1055},{"EN":1050},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>\u003Cjats:italic>Introduction\u003C\u002Fjats:italic>: A reliable and quantitative method for measuring motion of the thumb is lacking. In particular, review of the previous methods of motion analysis of the thumb joints shows that there is no objective method for clinicians to assess the impairment of the thumb trapeziometacarpal (TMC) joint. Based on the concept of the three‐dimensional (3‐D) space within which the first metacarpal can move relative to the trapezium (a concept of defining and measuring the workspace of the TMC motion), we present a quantitative method for measuring motion and impairment (loss of function) of the TMC joint.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:italic>Methods\u003C\u002Fjats:italic>: Twenty normal subjects were recruited in this study. An electromagnetic device was placed over the thumb metacarpal and long finger metacarpal, the 3‐D relationship between them previously established. We measured the position and orientation of the TMC motion in space. Maximum movements of the thumb TMC joint in circumduction, flexion–extension and abduction–adduction were used to construct the 3‐D maximal workspace of the TMC joint. Mathematical methods were used to verify the model and calculate the maximal workspace.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:italic>Results\u003C\u002Fjats:italic>: The results of this study demonstrate accurate and repeatable measurement of 3‐D TMC motion with high statistical reliability and low variability of the maximal TMC workspace. A statistically significant linear correlation between the maximal surface area and the square of the first metacarpal length was obtained.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:italic>Conclusion\u003C\u002Fjats:italic>: We conclude that a quantitatively comparative measurement of the range of motion of the TMC joint can be obtained with potential to measure motion in joints affected by arthritis or trauma and measured in both dynamic and static positions of the thumb. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.\u003C\u002Fjats:p>",{"EN":1052},"A quantitative method to measure maximal workspace of the trapeziometacarpal joint—normal model development",{"VOID":1054},"10.1016\u002Fj.orthres.2003.08.016",{"VOID":1056},"[\"12716053537011351495\"]","2024-05-05T01:36:38.941+00:00","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026603002146",[1060,1075,1100,1112,1124,1136],{"id":1061,"sortIndex":329,"researcher":24,"roles":1062,"affiliations":1063,"properties":1072},"27312030-1065-4f34-a13d-9025aed12515",[130],[1064],{"id":24,"sortIndex":25,"affiliation":1065,"properties":24},{"id":1066,"createTime":1067,"updateTime":1067,"relativeEntities":1068,"slug":24,"properties":1069,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7500aaef-f494-438b-b3b1-532be5974459","2023-12-29T11:07:38.591+00:00",[],{"title":1070},{"VI":1071},"Biomechanics Laboratory, Department of Orthopedics, Guggenheim 128, Mayo Clinic, Rochester, MN 55905, USA",{"title":1073},{"VI":1074},"Fong-Chin Su",{"id":1076,"sortIndex":25,"researcher":24,"roles":1077,"affiliations":1078,"properties":1095},"98dc22de-0e4d-42c6-b88b-38b3f9dc30da",[130],[1079,1084],{"id":24,"sortIndex":25,"affiliation":1080,"properties":24},{"id":1066,"createTime":1067,"updateTime":1067,"relativeEntities":1081,"slug":24,"properties":1082,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1083},{"VI":1071},{"id":1085,"sortIndex":173,"affiliation":1086,"properties":24},"7d7e06d8-b1cd-453c-b97f-71661b59e230",{"id":1087,"createTime":1088,"updateTime":1089,"relativeEntities":1090,"slug":1091,"properties":1092,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0f0084a9-034e-49f1-a33d-1c696934f5ad","2024-01-12T20:59:08.581+00:00","2024-09-20T18:43:50.477+00:00",[],"Institute-of-Biomedical-Engineering-National-Cheng-Kung-University-Tainan-Taiwan",{"title":1093},{"VI":1094},"Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan",{"title":1096,"gsAuthor":1098},{"VI":1097},"Li-Chieh Kuo",{"VOID":1099},"[\"rsbbFGwAAAAJ\"]",{"id":1101,"sortIndex":311,"researcher":24,"roles":1102,"affiliations":1103,"properties":1109},"096b6e30-e054-48e2-9288-486fb3746cc4",[130],[1104],{"id":24,"sortIndex":25,"affiliation":1105,"properties":24},{"id":1066,"createTime":1067,"updateTime":1067,"relativeEntities":1106,"slug":24,"properties":1107,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1108},{"VI":1071},{"title":1110},{"VI":1111},"Kai-Nan An",{"id":1113,"sortIndex":128,"researcher":24,"roles":1114,"affiliations":1115,"properties":1121},"d66c0058-0a8e-4ce1-993e-312b14082179",[130],[1116],{"id":24,"sortIndex":25,"affiliation":1117,"properties":24},{"id":1066,"createTime":1067,"updateTime":1067,"relativeEntities":1118,"slug":24,"properties":1119,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1120},{"VI":1071},{"title":1122},{"VI":1123},"Qing-Shan Chen",{"id":1125,"sortIndex":173,"researcher":24,"roles":1126,"affiliations":1127,"properties":1133},"a4763191-a75c-4e7c-92ab-af1f834942c5",[130],[1128],{"id":24,"sortIndex":25,"affiliation":1129,"properties":24},{"id":1066,"createTime":1067,"updateTime":1067,"relativeEntities":1130,"slug":24,"properties":1131,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1132},{"VI":1071},{"title":1134},{"VI":1135},"William P Cooney",{"id":1137,"sortIndex":145,"researcher":24,"roles":1138,"affiliations":1139,"properties":1145},"32088614-3e43-428e-a4af-d87d0694b982",[130],[1140],{"id":24,"sortIndex":25,"affiliation":1141,"properties":24},{"id":1066,"createTime":1067,"updateTime":1067,"relativeEntities":1142,"slug":24,"properties":1143,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1144},{"VI":1071},{"title":1146,"gsAuthor":1148},{"VI":1147},"Kenton R Kaufman",{"VOID":1149},"[\"_41x-KoAAAAJ\"]",{"url":1058,"publisher":1151,"properties":1181},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1152,"slug":10,"properties":1153,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1159,"manageAffiliations":1160,"indexDatabases":1161,"url":96,"thumbnailPath":24,"statistic":1176,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1154,"issn":1155,"introduce":1156,"eissn":1157,"title":1158},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1162,1169],{"id":59,"indexDatabase":1163,"url":74,"indexYears":24,"academicFieldIds":1168,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1164,"label":1165,"description":1166,"key":70,"publicationTags":1167,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":1170,"url":91,"indexYears":92,"academicFieldIds":1175,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1171,"label":1172,"description":1173,"key":88,"publicationTags":1174,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":1177,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":1178,"totalCitation":25,"totalCitationByYear":1179,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":1180,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":1182,"pages":1184},{"VOID":1183},"22",{"VOID":1185},"600-606",50,{"total":1186,"publishYear":1188,"statisticByYear":1189},2004,{"2005":173,"2006":329,"2007":329,"2008":329,"2009":329,"2010":311,"2011":145,"2012":145,"2013":145,"2014":311,"2015":173,"2016":329,"2017":173,"2018":145,"2019":173,"2021":145,"2022":173,"2023":173,"2024":145,"2025":173},"2004-05-01","2026-04-11T23:35:19.210+00:00",[1193,1199,1204,1210,1213,1216,1222,1228,1233,1238,1241,1246,1251,1254,1257,1263,1267,1273,1276],{"id":1194,"text":1195,"url":1196,"identifiers":1197},"4c68646b-0035-4279-8000-0006b275d4fa","1990, A guide to the evaluation of permanent impairment","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":1198},"10.1007\u002Fs10440-022-00541-7",{"id":1200,"text":1201,"url":1202,"identifiers":1203},"89f3a72d-29ba-4f01-9b82-109b8769b902","10.1016\u002F0021-9290(88)90225-4","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0021929088902254",{"doi":1201},{"id":1205,"text":1206,"url":1207,"identifiers":1208},"66f5f9d7-4dfd-4cc9-a161-c616b71cc2dd","Boyes J, 1950, Flexor‐tendon grafts in the fingers and thumb. An evaluation of the end results, J Bone Joint Surg, 32, 489, 10.2106\u002F00004623-195032030-00002","http:\u002F\u002Fjournals.lww.com\u002F00004623-195032030-00002",{"doi":1209},"10.2106\u002F00004623-195032030-00002",{"id":24,"text":1211,"url":24,"identifiers":1212},"10.1016\u002FS0363-5023(86)80137-X",{"doi":1211},{"id":24,"text":1214,"url":24,"identifiers":1215},"10.1016\u002FS0363-5023(84)80048-9",{"doi":1214},{"id":1217,"text":1218,"url":1219,"identifiers":1220},"e2d2c3dc-fcf6-42ff-8a5d-7367b525aabb","Cooney WP, 1987, Total arthroplasty of the thumb TMC joint, Clin Orthop, 220, 35, 10.1097\u002F00003086-198707000-00006","http:\u002F\u002Fjournals.lww.com\u002F00003086-198707000-00006",{"doi":1221},"10.1097\u002F00003086-198707000-00006",{"id":1223,"text":1224,"url":1225,"identifiers":1226},"4dc2b0a4-ceb9-4676-aa03-cd3ac72cdc30","Cooney WPMJL, 1981, The kinesiology of the thumb trapeziometacarpal joint, J Bone Joint Surg—Am, 63, 1371, 10.2106\u002F00004623-198163090-00002","http:\u002F\u002Fjournals.lww.com\u002F00004623-198163090-00002",{"doi":1227},"10.2106\u002F00004623-198163090-00002",{"id":1229,"text":1230,"url":1231,"identifiers":1232},"d631721d-4ee2-4564-81b9-0300473538f7","10.3109\u002F17453676608989403","https:\u002F\u002Factaorthop.org\u002Factao\u002Farticle\u002Fview\u002F30200",{"doi":1230},{"id":1234,"text":1235,"url":1236,"identifiers":1237},"5f463ada-49b4-476e-9d22-01502e1a6c04","10.1002\u002Fjor.1100100319","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjor.1100100319",{"doi":1235},{"id":24,"text":1239,"url":24,"identifiers":1240},"10.1016\u002FS0363-5023(96)80002-5",{"doi":1239},{"id":1242,"text":1243,"url":1244,"identifiers":1245},"7048efc1-0d4b-4b67-bc2c-7b4842dc6af8","10.1002\u002Fjor.1100120209","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjor.1100120209",{"doi":1243},{"id":1247,"text":1248,"url":1249,"identifiers":1250},"2856daa2-a3c8-4ebe-99f8-fa2037ca9bfc","10.1002\u002Fjor.1100120208","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fjor.1100120208",{"doi":1248},{"id":24,"text":1252,"url":24,"identifiers":1253},"Kapanji I, 1981, The hand",{},{"id":24,"text":1255,"url":24,"identifiers":1256},"10.2307\u002F2683704",{"doi":1255},{"id":1258,"text":1259,"url":1260,"identifiers":1261},"612b40a5-1c45-49f6-a745-107c3a099fb4","Litchman H, 1974, Determination of finger‐motion impairment by linear measurement. Description of method and comparison with angular measurement, J Bone Joint Surg—Am, 56, 85, 10.2106\u002F00004623-197456010-00010","http:\u002F\u002Fjournals.lww.com\u002F00004623-197456010-00010",{"doi":1262},"10.2106\u002F00004623-197456010-00010",{"id":24,"text":1264,"url":24,"identifiers":1265},"Marzke M, 1992, Evolutionary development of the human thumb, Hand Clinics, 8, 1, 10.1016\u002FS0749-0712(21)00687-9",{"doi":1266},"10.1016\u002FS0749-0712(21)00687-9",{"id":1268,"text":1269,"url":1270,"identifiers":1271},"e4ec4ad8-9fcf-4a27-89aa-31d0d52a51dc","Strickland J, 1985, Results of flexor tendon surgery in zone II, Hand Clinics, 1, 167, 10.1016\u002FS0749-0712(21)01341-X","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS074907122101341X",{"doi":1272},"10.1016\u002Fs0749-0712(21)01341-x",{"id":24,"text":1274,"url":24,"identifiers":1275},"10.1016\u002FS0363-5023(83)80253-6",{"doi":1274},{"id":1277,"text":1278,"url":1279,"identifiers":1280},"6a03f3f2-44d2-4f5d-9ade-e3363eedb317","10.1053\u002Fjhsu.1999.0483","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0363502399985738",{"doi":1278},{"id":1282,"createTime":1283,"updateTime":1284,"relativeEntities":1285,"slug":1286,"properties":1287,"entityType":123,"verifyStatus":244,"verifyTime":1284,"verifyNote":246,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":1296,"fullTextUrl":24,"authors":1297,"publicationType":184,"publisherRelationship":1395,"citationCount":24,"citationInfo":24,"publishDate":1430,"publishYear":1188,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"12325926-4dbf-4571-ad78-5ca61cfbd84e","2023-12-03T13:04:56.924+00:00","2025-02-13T23:30:33.754+00:00",[],"Early-osteoblastic-differentiation-induced-by-dexamethasone-enhances-adenoviral-gene-delivery-to-marrow-stromal-cells",{"references":1288,"abstract":1290,"title":1292,"doi":1294},{"VOID":1289},"10.1002\u002F1097-4644(20010315)80:4\u003C532::AID-JCB1007>3.0.CO;2-B\n10.1002\u002F(SICI)1097-4644(199702)64:2\u003C278::AID-JCB11>3.0.CO;2-F\n10.2106\u002F00004623-199807000-00007\n10.1002\u002Fjor.1100160202\n10.1002\u002F(SICI)1097-4644(20000501)77:2\u003C265::AID-JCB9>3.0.CO;2-6\n10.1002\u002F(SICI)1097-4644(19960501)61:2\u003C182::AID-JCB3>3.0.CO;2-Q\nGoshimaJ GoldbergVM CaplanAI. The osteogenic potential of culture‐expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks.Clin Orthop1991;298–311.\n10.1038\u002Fsj.gt.3301772\n10.1002\u002F(SICI)1097-4644(199702)64:2\u003C295::AID-JCB12>3.0.CO;2-I\n10.1016\u002FS0963-6897(96)00279-5\n10.1016\u002FS0169-409X(00)00078-8\n10.1002\u002F(SICI)1097-4636(20000305)49:3\u003C328::AID-JBM5>3.0.CO;2-Q\n10.1089\u002F10430340050015248\n10.1097\u002F00007890-199811270-00002\n10.2106\u002F00004623-199907000-00002\n10.1002\u002Fjcp.1041580322\n10.1007\u002FBF00225804\n10.1128\u002FJVI.68.10.6811-6814.1994\n10.3109\u002F17453679008993556\n10.1002\u002Fjcb.1106\n10.1002\u002F(SICI)1097-4644(19981001)71:1\u003C55::AID-JCB6>3.0.CO;2-0\n10.1038\u002Fnbt0398-247\n10.1002\u002Fjor.1100170217\n10.1210\u002Fen.130.3.1318\n10.3181\u002F00379727-211-43970\n10.1002\u002F(SICI)1097-4636(19980915)41:4\u003C568::AID-JBM8>3.0.CO;2-A",{"EN":1291},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>We investigated the implications of induced osteogenic differentiation on gene delivery in multipotent rat marrow stromal cells (MSCs). Prior to genetic manipulation cells were cultured with or without osteogenic supplements (5 ± 10\u003Cjats:sup>−8\u003C\u002Fjats:sup> M dexamethasone, 160 μM l‐ascorbic acid 2‐phosphate, and 10 mM β‐glycerophosphate). Comparison of liposome, retroviral, and adenoviral vectors demonstrated that all three vectors could mediate gene delivery to primary rat MSCs. When these vectors were applied in the absence or presence of osteogenic supplements, we found that MSCs differentiated prior to transduction with adenovirus type 5 vectors produced a 300% increase in transgene expression compared to MSCs that were not exposed to osteogenic supplements. This differentiation effect appeared specific to adenoviral mediated gene delivery, since there was minimal increase in retroviral gene delivery and no increase in liposome gene delivery when MSCs were treated with osteogenic supplements. In addition, we also determined this increase in transgene production to occur at a higher concentration of dexamethasone (5 ± 10\u003Cjats:sup>−8\u003C\u002Fjats:sup> M) in the culture medium of MSCs prior to adenoviral transduction. We found that this increased transgene production could be extended to the osteogenic protein, human bone morphogenetic protein 2 (hBMP‐2). When delivered by an adenoviral vector, hBMP‐2 transgene production could be increased from 1.4 ng\u002F10\u003Cjats:sup>5\u003C\u002Fjats:sup> cells\u002F3 days to 4.3 ng\u002F10\u003Cjats:sup>5\u003C\u002Fjats:sup> cells\u002F3 days by culture of MSCs with osteogenic supplements prior to transduction. These results indicate that the utility of MSCs as a therapeutic protein delivery mechanism through genetic manipulation can be enhanced by pre‐culture of these cells with dexamethasone. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.\u003C\u002Fjats:p>",{"EN":1293},"Early osteoblastic differentiation induced by dexamethasone enhances adenoviral gene delivery to marrow stromal cells",{"VOID":1295},"10.1016\u002Fj.orthres.2003.08.006","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026603002055",[1298,1315,1368,1380],{"id":1299,"sortIndex":145,"researcher":24,"roles":1300,"affiliations":1301,"properties":1312},"0ff850a1-a8e8-4e23-90e9-5bf70447dac8",[130],[1302],{"id":24,"sortIndex":25,"affiliation":1303,"properties":24},{"id":1304,"createTime":1305,"updateTime":1306,"relativeEntities":1307,"slug":1308,"properties":1309,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"93f00a12-7ef2-48a2-9d8c-dfe0cb413cff","2024-01-26T14:52:06.503+00:00","2024-10-03T01:28:24.055+00:00",[],"Department-of-Bioengineering-Rice-University-Houston-TX-USA",{"title":1310},{"VI":1311},"Department of Bioengineering Rice University Houston TX USA",{"title":1313},{"VI":1314},"Antonios G Mikos",{"id":1316,"sortIndex":128,"researcher":24,"roles":1317,"affiliations":1318,"properties":1365},"fde85e8e-c56e-47a5-baf2-459b104ca0ed",[130],[1319,1329,1339,1353],{"id":1320,"sortIndex":173,"affiliation":1321,"properties":1328},"990ca3f3-af67-4638-9f70-ba318d20fbeb",{"id":1322,"createTime":1323,"updateTime":1323,"relativeEntities":1324,"slug":24,"properties":1325,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"cb994b45-a97a-487c-883c-0e647134be31","2023-12-03T13:04:56.943+00:00",[],{"title":1326},{"VI":1327},"Department of Immunology, Baylor College of Medicine, Houston, TX, USA",{},{"id":1330,"sortIndex":145,"affiliation":1331,"properties":1338},"7eeb296e-dd70-4c65-84c9-0ea6d4d16568",{"id":1332,"createTime":1333,"updateTime":1333,"relativeEntities":1334,"slug":24,"properties":1335,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"1640fdae-9130-4f5b-9d8b-ae1d6b82775f","2023-12-04T08:14:16.611+00:00",[],{"title":1336},{"VI":1337},"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA",{},{"id":1340,"sortIndex":128,"affiliation":1341,"properties":1350},"f6956231-3a33-4cf9-80dc-83dce77c3437",{"id":1342,"createTime":1343,"updateTime":1344,"relativeEntities":1345,"slug":1346,"properties":1347,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0a9bbeaf-c60c-479f-880e-620d14e06f0b","2023-12-12T06:53:37.723+00:00","2025-06-11T23:30:34.495+00:00",[],"Department-of-Molecular-and-Human-Genetics-Baylor-College-of-Medicine-Houston-TX-United-States",{"title":1348},{"VI":1349},"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States",{"title":1351},{"VI":1352},"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA",{"id":1354,"sortIndex":25,"affiliation":1355,"properties":1362},"16d8dd7f-3b05-4c3f-be51-c354749133f9",{"id":1356,"createTime":1357,"updateTime":1357,"relativeEntities":1358,"slug":24,"properties":1359,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"0e433c42-9785-42f3-b24f-f7316fba8730","2023-12-31T10:37:39.258+00:00",[],{"title":1360},{"VI":1361},"Department of Bioengineering, Rice University, Houston, TX, United States",{"title":1363},{"VI":1364},"Department of Bioengineering, Rice University, Houston, TX, USA",{"title":1366},{"VI":1367},"Michael A Barry",{"id":1369,"sortIndex":173,"researcher":24,"roles":1370,"affiliations":1371,"properties":1377},"a31a8a24-e796-4b2d-8f72-98bfb86da999",[130],[1372],{"id":24,"sortIndex":25,"affiliation":1373,"properties":24},{"id":1322,"createTime":1323,"updateTime":1323,"relativeEntities":1374,"slug":24,"properties":1375,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1376},{"VI":1327},{"title":1378},{"VI":1379},"M Brandon Parrott",{"id":1381,"sortIndex":25,"researcher":24,"roles":1382,"affiliations":1383,"properties":1392},"28fb924f-4628-4eaf-9e9e-d5323fa55d33",[130],[1384],{"id":1385,"sortIndex":25,"affiliation":1386,"properties":1390},"82720564-7885-4457-b8e0-ce14244efc74",{"id":1356,"createTime":1357,"updateTime":1357,"relativeEntities":1387,"slug":24,"properties":1388,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1389},{"VI":1361},{"title":1391},{"VI":1364},{"title":1393},{"VI":1394},"Jeremy S Blum",{"url":1296,"publisher":1396,"properties":1426},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1397,"slug":10,"properties":1398,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1404,"manageAffiliations":1405,"indexDatabases":1406,"url":96,"thumbnailPath":24,"statistic":1421,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1399,"issn":1400,"introduce":1401,"eissn":1402,"title":1403},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1407,1414],{"id":59,"indexDatabase":1408,"url":74,"indexYears":24,"academicFieldIds":1413,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1409,"label":1410,"description":1411,"key":70,"publicationTags":1412,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":1415,"url":91,"indexYears":92,"academicFieldIds":1420,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1416,"label":1417,"description":1418,"key":88,"publicationTags":1419,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":1422,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":1423,"totalCitation":25,"totalCitationByYear":1424,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":1425,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":1427,"pages":1428},{"VOID":1183},{"VOID":1429},"411-416","2004-03-01",{"id":1432,"createTime":1433,"updateTime":1434,"relativeEntities":1435,"slug":1436,"properties":1437,"entityType":123,"verifyStatus":244,"verifyTime":1434,"verifyNote":246,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":1446,"fullTextUrl":24,"authors":1447,"publicationType":184,"publisherRelationship":1499,"citationCount":24,"citationInfo":24,"publishDate":1534,"publishYear":875,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"c27227f6-8d78-4d36-8838-7ce2239fa5a0","2024-01-29T22:46:56.937+00:00","2024-12-13T23:29:03.246+00:00",[],"Molecular-aspects-of-healing-in-stabilized-and-non-stabilized-fractures",{"references":1438,"abstract":1440,"title":1442,"doi":1444},{"VOID":1439},"Albrecht UEG, 1997, Molecular and cellular methods in developmental toxicology, 23\n10.1007\u002FBF00308311\n10.1098\u002Frstb.1986.0038\nAshhurst DE, 1994, Bone, 61\n10.1006\u002Fdbio.1995.0010\n10.1002\u002Fjor.1100020115\nBourque WT, 1993, Expression of four growth factors during fracture repair, Int J Dev Biol, 37, 573\nBourque WT, 1992, A reproducible method for producing and quantifying the stages of fracture repair, Lab Anim Sci, 42, 369\n10.1097\u002F00005131-199705000-00002\n10.1016\u002FS0749-0712(21)00281-X\nCaplan AI, 1988, Bone development, Ciba Found Symp, 136, 3\n10.1002\u002Fjor.1100060517\n10.1016\u002F8756-3282(95)00373-8\n10.1016\u002F0021-9290(91)90373-U\n10.1016\u002FS0925-4773(99)00142-2\n10.1111\u002Fj.1749-6632.1998.tb10105.x\n10.1002\u002Fjor.1100110219\n10.1016\u002FS0925-4773(97)00145-7\n10.1006\u002Fdbio.1996.0300\n10.1002\u002Fjbmr.5650090510\n10.1006\u002Fdbio.1998.9181\nSchneider RA, 1998, Development and regeneration of the musculoskeletal system, Curr Opinion Orthop, 9, 20, 10.1097\u002F00001433-199812000-00004\n10.1126\u002Fscience.273.5275.613\n10.1016\u002FS0925-4773(97)00203-7\n10.1126\u002Fscience.7684161",{"EN":1441},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>Bone formation is a continuous process that is initiated during fetal development and persists in adults in the form of bone regeneration and remodeling. These latter two aspects of bone formation are clearly influenced by the mechanical environment. In this study we tested the hypothesis that alterations in the mechanical environment regulate the program of mesenchymal cell differentiation, and thus the formation of a cartilage or bony callus, at the site of injury. As a first step in testing this hypothesis we produced stabilized and non‐stabilized tibial fractures in a mouse model, then used molecular and cellular methods to examine the stage of healing. Using the “molecular map” of the fracture callus, we divided our analyzes into three phases of fracture healing: the inflammatory or initial phase of healing, the soft callus or intermediate stage, and the hard callus stage. Our results show that \u003Cjats:italic>indian hedgehog(ihh)\u003C\u002Fjats:italic>, which regulates aspects of chondrocyte maturation during fetal and early postnatal skeletogenesis, was expressed earlier in an non‐stabilized fracture callus as compared to a stabilized callus, \u003Cjats:italic>ihh\u003C\u002Fjats:italic> persisted in the non‐stabilized fracture whereas its expression was down‐regulated in the stabilized bone. IHH exerts its effects on chondrocyte maturation through a feedback loop that may involve bone morphogenetic protein 6 [\u003Cjats:italic>bmp6\u003C\u002Fjats:italic>; (S. Pathi, J.B. Rutenberg, R.L. Johnson, A. Vortkamp, Developmental Biology 209 (1999) 239–253)] and the transcription factor \u003Cjats:italic>gli3, bmp6\u003C\u002Fjats:italic> and \u003Cjats:italic>gli3\u003C\u002Fjats:italic> were re‐induced in domain adjacent to the \u003Cjats:italic>ihh\u003C\u002Fjats:italic>‐positive cells during the soft and hard callus stages of healing. Thus, stabilizing the fracture, which circumvents or decreases the cartilaginous phase of bone repair, correlates with a decrease in \u003Cjats:italic>ihh\u003C\u002Fjats:italic> signaling in the fracture callus. Collectively, our results illustrate that the \u003Cjats:italic>ihh\u003C\u002Fjats:italic> signaling pathway participates in fracture repair, and that the mechanical environment affects the temporal induction of \u003Cjats:italic>ihh\u003C\u002Fjats:italic>, \u003Cjats:italic>bmp6\u003C\u002Fjats:italic> and \u003Cjats:italic>gli3.\u003C\u002Fjats:italic> These data support the hypothesis that mechanical influences affect mesenchymal cell differentiation to bone. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.\u003C\u002Fjats:p>",{"EN":1443},"Molecular aspects of healing in stabilized and non‐stabilized fractures",{"VOID":1445},"10.1016\u002Fs0736-0266(00)00006-1","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026600000061",[1448,1463,1475,1487],{"id":1449,"sortIndex":25,"researcher":24,"roles":1450,"affiliations":1451,"properties":1460},"af38306a-a33e-4f0a-98e6-0ec817f760e3",[130],[1452],{"id":24,"sortIndex":25,"affiliation":1453,"properties":24},{"id":1454,"createTime":1455,"updateTime":1455,"relativeEntities":1456,"slug":24,"properties":1457,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"43e3cd0f-d4ad-4b99-a74f-6246ed8ac4ba","2024-01-29T22:46:57.141+00:00",[],{"title":1458},{"VI":1459},"Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143-0514, USA",{"title":1461},{"VI":1462},"A.X Le",{"id":1464,"sortIndex":173,"researcher":24,"roles":1465,"affiliations":1466,"properties":1472},"9ab370f7-ebbe-49c2-9eae-4732c55903fa",[130],[1467],{"id":24,"sortIndex":25,"affiliation":1468,"properties":24},{"id":1454,"createTime":1455,"updateTime":1455,"relativeEntities":1469,"slug":24,"properties":1470,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1471},{"VI":1459},{"title":1473},{"VI":1474},"T Miclau",{"id":1476,"sortIndex":145,"researcher":24,"roles":1477,"affiliations":1478,"properties":1484},"7cc5c9d8-48ae-49e1-aa3f-e561da84f0e6",[130],[1479],{"id":24,"sortIndex":25,"affiliation":1480,"properties":24},{"id":1454,"createTime":1455,"updateTime":1455,"relativeEntities":1481,"slug":24,"properties":1482,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1483},{"VI":1459},{"title":1485},{"VI":1486},"D Hu",{"id":1488,"sortIndex":128,"researcher":24,"roles":1489,"affiliations":1490,"properties":1496},"af7e4fea-a26f-488b-8185-563046bbd261",[130],[1491],{"id":24,"sortIndex":25,"affiliation":1492,"properties":24},{"id":1454,"createTime":1455,"updateTime":1455,"relativeEntities":1493,"slug":24,"properties":1494,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1495},{"VI":1459},{"title":1497},{"VI":1498},"J.A Helms",{"url":1446,"publisher":1500,"properties":1530},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1501,"slug":10,"properties":1502,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1508,"manageAffiliations":1509,"indexDatabases":1510,"url":96,"thumbnailPath":24,"statistic":1525,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1503,"issn":1504,"introduce":1505,"eissn":1506,"title":1507},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1511,1518],{"id":59,"indexDatabase":1512,"url":74,"indexYears":24,"academicFieldIds":1517,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1513,"label":1514,"description":1515,"key":70,"publicationTags":1516,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":1519,"url":91,"indexYears":92,"academicFieldIds":1524,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1520,"label":1521,"description":1522,"key":88,"publicationTags":1523,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":1526,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":1527,"totalCitation":25,"totalCitationByYear":1528,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":1529,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":1531,"pages":1532},{"VOID":871},{"VOID":1533},"78-84","2001-01-01",{"id":1536,"createTime":1537,"updateTime":1537,"relativeEntities":1538,"slug":24,"properties":1539,"entityType":123,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":1548,"fullTextUrl":24,"authors":1549,"publicationType":184,"publisherRelationship":1655,"citationCount":24,"citationInfo":24,"publishDate":1690,"publishYear":1041,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"fc2a3405-7324-452b-b5e1-7b227e898157","2023-12-22T23:28:53.338+00:00",[],{"references":1540,"abstract":1542,"title":1544,"doi":1546},{"VOID":1541},"Behiri JC, 1987, Biomechanics: basic and applied research\n10.1016\u002F0021-9290(83)90107-0\nBonfield W, 1989, Applications of fracture mechanics to composite materials, 615, 10.1016\u002FB978-0-444-87286-9.50019-X\n10.1016\u002F0021-9290(88)90132-7\n10.1002\u002Fjbm.820070324\nCorandon G, 1986, A fractographic study of human long bone, J Biomech, 19, 207, 10.1016\u002F0021-9290(86)90153-3\nDaviesHMS McCarthyRN JeffcottLB. Surface strain on the dorsal metacarpus of thoroughbreds at different speeds and gaits. Acta Anatomica1993:146–53.\nGibson VA, 2000, Fatigue behavior of equine third metacarpal bone tissue\n10.1002\u002Fjor.1100130609\n10.1016\u002F0021-9290(92)90044-2\n10.1002\u002Fjbmr.5650080902\n10.1016\u002F8756-3282(96)00167-6\n10.1016\u002FS0021-9290(96)00113-3\n10.1016\u002FS0021-9290(96)80002-9\n10.1002\u002Fjor.1100140517\n10.1016\u002F0021-9290(78)90055-6\n10.1016\u002F0021-9290(84)90011-3\nNunamaker DM, 1991, In vitro comparison of Thoroughbred and Standardbred racehorses with regard to local fatigue failure of the third metacarpal bone, Am J Vet Res, 52, 97\n10.1002\u002Fjor.1100080417\nPiekarski K, 1984, Nat living biomater\n10.1063\u002F1.1658323\nPopeMH MurphyMC. Fracture energy of bone in a shear mode. Med Biol Eng1974;12.\n10.1016\u002F0021-9290(72)90004-8\n10.1016\u002F0021-9290(74)90070-0\nStover SM, 1992, Histologic features of the dorsal cortex of the third metacarpal bone mid‐diaphysis during postnatal growth in Thoroughbred horses, J Anat, 181, 455",{"EN":1543},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:p>An important concept in bone mechanics is that osteons influence mechanical properties in several ways, including contributing to toughness and fatigue strength by debonding from the interstitial matrix so as to „bridge”︁ developing cracks. Observations of „pulled out„ osteons on fracture surfaces are thought to be indicative of such behavior. We tested the hypothesis that osteon pullout varies with mode of loading (fatigue vs. monotonic), cortical region, elastic modulus, and fatigue life. Mid‐diaphseal beams from the dorsal, medial, and lateral regions of the equine third metacarpal bone were fractured in four point bending by monotonic loading to failure under deflection control, with or without 10\u003Cjats:sup>5\u003C\u002Fjats:sup> cycles of previous fatigue loading producing 5000 microstrain (15–20% of the expected failure strain) on the first cycle; or sinusoidal fatigue loading to failure, under load or deflection control, with the initial cycle producing 10,000 microstrain (30–40% of the expected failure strain). Using scanning electron microscopy, percent fracture surface area exhibiting osteon pullout (%OP.Ar) was measured. Monotonically loaded specimens and the compression side of fatigue fracture surfaces exhibited no osteon pullout. In load‐controlled fatigue, pullout was present on the tension side of fracture surfaces, was regionally dependent (occurring to a greater amount dorsally), and was correlated negatively with elastic modulus and positively with fatigue life. Regional variation in %OP.Ar was also significant for the pooled (load and deflection controlled) fatigue specimens. %OP.Ar was nearly significantly greater in deflection controlled fatigue specimens than in load‐controlled specimens (\u003Cjats:italic>p\u003C\u002Fjats:italic> < 0.059). The data suggest that tensile fatigue loading of cortical bone eventually introduces damage that results in osteonal debonding and pullout, which is also associated with increased fatigue life via mechanisms that are not yet clear.\u003C\u002Fjats:p>\u003Cjats:p>© 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.\u003C\u002Fjats:p>",{"EN":1545},"Osteon pullout in the equine third metacarpal bone: Effects of ex vivo fatigue",{"VOID":1547},"10.1016\u002Fs0736-0266(02)00232-2","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026602002322",[1550,1565,1577,1589,1601,1616,1631,1643],{"id":1551,"sortIndex":329,"researcher":24,"roles":1552,"affiliations":1553,"properties":1562},"be9f21c6-458c-477a-bb24-6a3e99afef13",[130],[1554],{"id":24,"sortIndex":25,"affiliation":1555,"properties":24},{"id":1556,"createTime":1557,"updateTime":1557,"relativeEntities":1558,"slug":24,"properties":1559,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"23da1646-6273-4525-8022-5381f8483475","2023-12-22T23:28:53.537+00:00",[],{"title":1560},{"VI":1561},"Orthopaedic Research Laboratories, School of Medicine, University of California at Davis, Davis, CA 95616, USA",{"title":1563},{"VI":1564},"C.S. Prater",{"id":1566,"sortIndex":25,"researcher":24,"roles":1567,"affiliations":1568,"properties":1574},"386b5302-7640-47ac-bc66-ea16a8e75a93",[130],[1569],{"id":24,"sortIndex":25,"affiliation":1570,"properties":24},{"id":1556,"createTime":1557,"updateTime":1557,"relativeEntities":1571,"slug":24,"properties":1572,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1573},{"VI":1561},{"title":1575},{"VI":1576},"L.P. Hiller",{"id":1578,"sortIndex":311,"researcher":24,"roles":1579,"affiliations":1580,"properties":1586},"e05ce53b-604e-4b25-b291-4438f4b9b28d",[130],[1581],{"id":24,"sortIndex":25,"affiliation":1582,"properties":24},{"id":1556,"createTime":1557,"updateTime":1557,"relativeEntities":1583,"slug":24,"properties":1584,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1585},{"VI":1561},{"title":1587},{"VI":1588},"S.J. Hazelwood",{"id":1590,"sortIndex":289,"researcher":24,"roles":1591,"affiliations":1592,"properties":1598},"0ea5a65c-eb2e-46df-be6c-4d44113b29b6",[130],[1593],{"id":24,"sortIndex":25,"affiliation":1594,"properties":24},{"id":1556,"createTime":1557,"updateTime":1557,"relativeEntities":1595,"slug":24,"properties":1596,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1597},{"VI":1561},{"title":1599},{"VI":1600},"R.B. Martin",{"id":1602,"sortIndex":173,"researcher":24,"roles":1603,"affiliations":1604,"properties":1613},"7bcceb9f-c09d-4645-ab36-9e46d912ed5f",[130],[1605],{"id":24,"sortIndex":25,"affiliation":1606,"properties":24},{"id":1607,"createTime":1608,"updateTime":1608,"relativeEntities":1609,"slug":24,"properties":1610,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b0bb265b-e024-4ec1-8e80-aecaaed04d4c","2024-01-15T09:17:31.071+00:00",[],{"title":1611},{"VI":1612},"J.D. Wheat Veterinary Orthopedic Research Laboratory, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA",{"title":1614},{"VI":1615},"S.M. Stover",{"id":1617,"sortIndex":128,"researcher":24,"roles":1618,"affiliations":1619,"properties":1628},"98d8335e-37bb-4a8e-822c-292adbdd991f",[130],[1620],{"id":24,"sortIndex":25,"affiliation":1621,"properties":24},{"id":1622,"createTime":1623,"updateTime":1623,"relativeEntities":1624,"slug":24,"properties":1625,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"a0252583-febf-422e-aab7-d2ff555ac815","2024-01-15T09:17:31.060+00:00",[],{"title":1626},{"VI":1627},"Department of Chemical Engineering and Materials Science, College of Engineering, University of California at Davis, Davis, CA 95616, USA",{"title":1629},{"VI":1630},"J.C. Gibeling",{"id":1632,"sortIndex":55,"researcher":24,"roles":1633,"affiliations":1634,"properties":1640},"f39abaa5-59ab-4e7f-8a8d-4c225196c7e3",[130],[1635],{"id":24,"sortIndex":25,"affiliation":1636,"properties":24},{"id":1556,"createTime":1557,"updateTime":1557,"relativeEntities":1637,"slug":24,"properties":1638,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1639},{"VI":1561},{"title":1641},{"VI":1642},"O.C. Yeh",{"id":1644,"sortIndex":145,"researcher":24,"roles":1645,"affiliations":1646,"properties":1652},"e7126318-b2f1-4661-b225-894991466a46",[130],[1647],{"id":24,"sortIndex":25,"affiliation":1648,"properties":24},{"id":1556,"createTime":1557,"updateTime":1557,"relativeEntities":1649,"slug":24,"properties":1650,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1651},{"VI":1561},{"title":1653},{"VI":1654},"V.A. Gibson",{"url":1548,"publisher":1656,"properties":1686},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1657,"slug":10,"properties":1658,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1664,"manageAffiliations":1665,"indexDatabases":1666,"url":96,"thumbnailPath":24,"statistic":1681,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1659,"issn":1660,"introduce":1661,"eissn":1662,"title":1663},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1667,1674],{"id":59,"indexDatabase":1668,"url":74,"indexYears":24,"academicFieldIds":1673,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1669,"label":1670,"description":1671,"key":70,"publicationTags":1672,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":1675,"url":91,"indexYears":92,"academicFieldIds":1680,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1676,"label":1677,"description":1678,"key":88,"publicationTags":1679,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":1682,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":1683,"totalCitation":25,"totalCitationByYear":1684,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":1685,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":1687,"pages":1688},{"VOID":1037},{"VOID":1689},"481-488","2003-05-01",{"id":1692,"createTime":1693,"updateTime":1694,"relativeEntities":1695,"slug":1696,"properties":1697,"entityType":123,"verifyStatus":244,"verifyTime":1694,"verifyNote":246,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"primaryUrl":1702,"fullTextUrl":24,"authors":1703,"publicationType":184,"publisherRelationship":1761,"citationCount":24,"citationInfo":24,"publishDate":747,"publishYear":222,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":24,"isForceReanalyzing":223},"c6bfca61-d811-4a20-8ab2-9037a05938b1","2023-12-11T22:54:23.102+00:00","2024-12-17T23:26:50.399+00:00",[],"Differences-in-stability-and-bone-remodeling-between-a-customized-uncemented-hydroxyapatite-coated-and-a-standard-cemented-femoral-stemA-randomized-study-with-use-of-radiostereometry-and-bone-densitometry",{"title":1698,"doi":1700},{"EN":1699},"Differences in stability and bone remodeling between a customized uncemented hydroxyapatite coated and a standard cemented femoral stemA randomized study with use of radiostereometry and bone densitometry",{"VOID":1701},"10.1016\u002Fj.orthres.2005.03.016","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0736026605001038",[1704,1719,1734,1746],{"id":1705,"sortIndex":173,"researcher":24,"roles":1706,"affiliations":1707,"properties":1716},"1eb8ff5c-2cc2-42a8-a2cc-71572edf898a",[130],[1708],{"id":24,"sortIndex":25,"affiliation":1709,"properties":24},{"id":1710,"createTime":1711,"updateTime":1711,"relativeEntities":1712,"slug":24,"properties":1713,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"738d7220-f108-43fa-ae5d-6b167d59e744","2023-12-29T18:40:10.520+00:00",[],{"title":1714},{"VI":1715},"Department of Orthopaedic Surgery, Trondheim University Hospital, Trondheim, Norway",{"title":1717},{"VI":1718},"Arild Aamodt",{"id":1720,"sortIndex":25,"researcher":24,"roles":1721,"affiliations":1722,"properties":1731},"e595e195-4ca1-41f7-8641-409d96f063da",[130],[1723],{"id":24,"sortIndex":25,"affiliation":1724,"properties":24},{"id":1725,"createTime":1726,"updateTime":1726,"relativeEntities":1727,"slug":24,"properties":1728,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7eb288a7-d20c-4dc8-be87-f36c0946e511","2023-12-11T22:54:23.120+00:00",[],{"title":1729},{"VI":1730},"Orthopaedic Centre, Ullevål University Hospital, Kirkeveien 166, N-0407 Oslo, Norway",{"title":1732},{"VI":1733},"Peter Grant",{"id":1735,"sortIndex":128,"researcher":24,"roles":1736,"affiliations":1737,"properties":1743},"5b45a022-f71b-44a8-9d5d-1778035fb63b",[130],[1738],{"id":24,"sortIndex":25,"affiliation":1739,"properties":24},{"id":1725,"createTime":1726,"updateTime":1726,"relativeEntities":1740,"slug":24,"properties":1741,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1742},{"VI":1730},{"title":1744},{"VI":1745},"Lars Nordsletten",{"id":1747,"sortIndex":145,"researcher":24,"roles":1748,"affiliations":1749,"properties":1758},"9293fd31-e797-4dd1-8036-2fda775ee791",[130],[1750],{"id":24,"sortIndex":25,"affiliation":1751,"properties":24},{"id":1752,"createTime":1753,"updateTime":1753,"relativeEntities":1754,"slug":24,"properties":1755,"entityType":44,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"d79341d4-1093-4b16-8cc8-b65974b8a7f1","2023-12-11T22:54:23.152+00:00",[],{"title":1756},{"VI":1757},"Center of Endocrinology, Aker University Hospital, Oslo, Norway",{"title":1759},{"VI":1760},"Jan A. Falch",{"url":1702,"publisher":1762,"properties":1792},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1763,"slug":10,"properties":1764,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1770,"manageAffiliations":1771,"indexDatabases":1772,"url":96,"thumbnailPath":24,"statistic":1787,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1765,"issn":1766,"introduce":1767,"eissn":1768,"title":1769},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1773,1780],{"id":59,"indexDatabase":1774,"url":74,"indexYears":24,"academicFieldIds":1779,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1775,"label":1776,"description":1777,"key":70,"publicationTags":1778,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"id":78,"indexDatabase":1781,"url":91,"indexYears":92,"academicFieldIds":1786,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1782,"label":1783,"description":1784,"key":88,"publicationTags":1785,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"impactFactor":25,"impactFactorByYear":1788,"i10Index":25,"i10IndexLast5Year":25,"totalPublication":99,"totalPublicationByYear":1789,"totalCitation":25,"totalCitationByYear":1790,"totalCitationPerPublication":25,"totalCitationPerPublicationByYear":1791,"hindexLast5Year":25,"hindex":25},{},{"2001":101,"2002":102,"2003":103,"2004":104,"2005":105},{},{},{"volume":1793,"pages":1794},{"VOID":218},{"VOID":1795},"1280-1285"]