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Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376:2367–75.\nWang J, Chen XY, Zhao Y, Yang Y, Wang W, Wu C, Yang B, Zhang Z, Zhang L, Liu Y, et al. pH-switchable antimicrobial nanofiber networks of hydrogel eradicate biofilm and rescue stalled healing in chronic wounds. ACS Nano. 2019;13:11686–97.\nZhong Y, Seidi F, Wang Y, Zheng L, Jin Y, Xiao H. Injectable chitosan hydrogels tailored with antibacterial and antioxidant dual functions for regenerative wound healing. Carbohydr Polym. 2022;298:120103.\nZhang X, Feng J, Feng W, Xu B, Zhang K, Ma G, Li Y, Yang M, Xu FJ. Glycosaminoglycan-based hydrogel delivery system regulates the wound microenvironment to rescue chronic wound healing. ACS Appl Mater Interfaces. 2022;14:31737–50.\nZhao X, Fu L, Zou H, He Y, Pan Y, Ye L, Huang Y, Fan W, Zhang J, Ma Y, et al. Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of tissue repair. J Nanobiotechnol. 2023;21:176.\nEverett E, Mathioudakis N. Update on management of diabetic foot ulcers. Ann N Y Acad Sci. 2018;1411:153–65.\nLiu X, Gao Q, Wu S, Qin H, Zhang T, Zheng X, Li B. Optically manipulated neutrophils as native microcrafts in vivo. ACS Cent Sci. 2022;8:1017–27.\nKolonics F, Szeifert V, Timár CI, Ligeti E, Lőrincz ÁM. The functional heterogeneity of neutrophil-derived extracellular vesicles reflects the status of the parent cell. Cells. 2020;9.\nTimár CI, Lorincz AM, Csépányi-Kömi R, Vályi-Nagy A, Nagy G, Buzás EI, Iványi Z, Kittel A, Powell DW, McLeish KR, Ligeti E. Antibacterial effect of microvesicles released from human neutrophilic granulocytes. Blood. 2013;121:510–8.\nBian D, Wu Y, Song G, Azizi R, Zamani A. The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review. Stem Cell Res Ther. 2022;13:24.\nQiu X, Liu J, Zheng C, Su Y, Bao L, Zhu B, Liu S, Wang L, Wang X, Wang Y, et al. Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis. Cell Prolif. 2020;53:e12830.\nMarofi F, Alexandrovna KI, Margiana R, Bahramali M, Suksatan W, Abdelbasset WK, Chupradit S, Nasimi M, Maashi MS. MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy. Stem Cell Res Ther. 2021;12:597.\nXie Y, Yu L, Cheng Z, Peng Y, Cao Z, Chen B, Duan Y, Wang Y. Shed-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy. J Nanobiotechnol. 2022;20:239.\nLiang Z, Chi YJ, Lin GQ, Luo SH, Jiang QY, Chen YK. MiRNA-26a promotes angiogenesis in a rat model of cerebral infarction via PI3K\u002FAKT and MAPK\u002FERK pathway. Eur Rev Med Pharmacol Sci. 2018;22:3485–92.\nCho HD, Lee KW, Won YS, Kim JH, Seo KI. Cultivated orostachys japonicus extract inhibits VEGF-induced angiogenesis via regulation of VEGFR2 signaling pathway in vitro and in vivo. J Ethnopharmacol. 2020;256:112664.\nGoswami AG, Basu S, Huda F, Pant J, Ghosh Kar A, Banerjee T, Shukla VK. An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications. Growth Factors. 2022;40:73–88.\nSahoo S, Kariya T, Ishikawa K. Targeted delivery of therapeutic agents to the heart. Nat Rev Cardiol. 2021;18:389–99.\nVader P, Mol EA, Pasterkamp G, Schiffelers RM. Extracellular vesicles for drug delivery. Adv Drug Deliv Rev. 2016;106:148–56.\nNarayanan K, Kumar S, Padmanabhan P, Gulyas B, Wan ACA, Rajendran VM. Lineage-specific exosomes could override extracellular matrix mediated human mesenchymal stem cell differentiation. Biomaterials. 2018;182:312–22.\nChan LK, Leung VY, Tam V, Lu WW, Sze KY, Cheung KM. Decellularized bovine intervertebral disc as a natural scaffold for xenogenic cell studies. Acta Biomater. 2013;9:5262–72.\nFiordalisi M, Silva AJ, Barbosa M, Gonçalves R, Caldeira J. Decellularized scaffolds for intervertebral disc regeneration. Trends Biotechnol. 2020;38:947–51.\nXing H, Zhang Z, Mao Q, Wang C, Zhou Y, Zhou X, Ying L, Xu H, Hu S, Zhang N. Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration. J Nanobiotechnol. 2021;19:264.\nSaldin LT, Cramer MC, Velankar SS, White LJ, Badylak SF. Extracellular matrix hydrogels from decellularized tissues: structure and function. Acta Biomater. 2017;49:1–15.\nQiu P, Li M, Chen K, Fang B, Chen P, Tang Z, Lin X, Fan S. Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis. Biomaterials. 2020;227:119552.\nQiao Y, Xu Z, Yu Y, Hou S, Geng J, Xiao T, Liang Y, Dong Q, Mei Y, Wang B, et al. Single cell derived spheres of umbilical cord mesenchymal stem cells enhance cell stemness properties, survival ability and therapeutic potential on liver failure. Biomaterials. 2020;227:119573.\nZhang J, Guan J, Niu X, Hu G, Guo S, Li Q, Xie Z, Zhang C, Wang Y. Exosomes released from human induced pluripotent stem cells-derived mscs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med. 2015;13:49.\nAlvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341–5.\nWu P, Zhang B, Ocansey DKW, Xu W, Qian H. Extracellular vesicles: a bright star of nanomedicine. Biomaterials. 2021;269:120467.\nMathieu M, Névo N, Jouve M, Valenzuela JI, Maurin M, Verweij FJ, Palmulli R, Lankar D, Dingli F, Loew D, et al. Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9. Nat Commun. 2021;12:4389.\nLauwers E, Wang YC, Gallardo R, Van der Kant R, Michiels E, Swerts J, Baatsen P, Zaiter SS, McAlpine SR, Gounko NV, et al. Hsp90 mediates membrane deformation and exosome release. Mol Cell. 2018;71:689–702e9.\nVillarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F. ISGylation controls exosome secretion by promoting lysosomal degradation of mvb proteins. Nat Commun. 2016;7:13588.\nDe Santis MM, Alsafadi HN, Tas S, Bölükbas DA, Prithiviraj S, Da Silva IAN, Mittendorfer M, Ota C, Stegmayr J, Daoud F, et al. Extracellular-matrix-reinforced bioinks for 3D bioprinting human tissue. Adv Mater. 2021;33:e2005476.\nSakina R, Llucià-Valldeperas A, Henriques Lourenço A, Harichandan A, Gelsomino S, Wieringa P, Mota C, Moroni L. Decellularization of porcine heart tissue to obtain extracellular matrix based hydrogels. Methods Cell Biol. 2020;157:3–21.\nHu Y, Tao R, Chen L, Xiong Y, Xue H, Hu L, Yan C, Xie X, Lin Z, Panayi AC, et al. Exosomes derived from pioglitazone-pretreated mscs accelerate diabetic wound healing through enhancing angiogenesis. J Nanobiotechnol. 2021;19:150.\nRowley AT, Nagalla RR, Wang SW, Liu WF. Extracellular matrix-based strategies for immunomodulatory biomaterials engineering. Adv Healthc Mater. 2019;8:e1801578.\nFan J, Lee CS, Kim S, Chen C, Aghaloo T, Lee M. Generation of small RNA-modulated exosome mimetics for bone regeneration. ACS Nano. 2020;14:11973–84.\nZhang W, Wang L, Guo H, Chen L, Huang X. Dapagliflozin-loaded exosome mimetics facilitate diabetic wound healing by hif-1α-mediated enhancement of angiogenesis. Adv Healthc Mater. 2023;12:e2202751.\nZhang Y, Yue T, Gu W, Liu A, Cheng M, Zheng H, Bao D, Li F, Piao JG. pH-responsive hierarchical H2S-releasing nano-disinfectant with deep-penetrating and anti-inflammatory properties for synergistically enhanced eradication of bacterial biofilms and wound infection. J Nanobiotechnol. 2022;20:55.\nWang Y, Yang Y, Shi Y, Song H, Yu C. Antibiotic-free antibacterial strategies enabled by nanomaterials: progress and perspectives. Adv Mater. 2020;32:e1904106.\nKwak G, Cheng J, Kim H, Song S, Lee SJ, Yang Y, Jeong JH, Lee JE, Messersmith PB, Kim SH. Sustained exosome-guided macrophage polarization using hydrolytically degradable peg hydrogels for cutaneous wound healing: identification of key proteins and miRNAs, and sustained release formulation. Small. 2022;18:e2200060.\nZhang L, Fan C, Hao W, Zhuang Y, Liu X, Zhao Y, Chen B, Xiao Z, Chen Y, Dai J. NSCs migration promoted and drug delivered exosomes-collagen scaffold via a bio-specific peptide for one-step spinal cord injury repair. Adv Healthc Mater. 2021;10:e2001896.\nMartino MM, Briquez PS, Güç E, Tortelli F, Kilarski WW, Metzger S, Rice JJ, Kuhn GA, Müller R, Swartz MA, Hubbell JA. Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Science. 2014;343:885–8.\nHou L, Coller J, Natu V, Hastie TJ, Huang NF. Combinatorial extracellular matrix microenvironments promote survival and phenotype of human induced pluripotent stem cell-derived endothelial cells in hypoxia. Acta Biomater. 2016;44:188–99.\nZhang S, Xiao T, Yu Y, Qiao Y, Xu Z, Geng J, Liang Y, Mei Y, Dong Q, Wang B, et al. The extracellular matrix enriched with membrane metalloendopeptidase and insulin-degrading enzyme suppresses the deposition of amyloid-beta peptide in alzheimer’s disease cell models. J Tissue Eng Regen Med. 2019;13:1759–69.\nFutrega K, King M, Lott WB, Doran MR. Treating the whole not the hole: necessary coupling of technologies for diabetic foot ulcer treatment. Trends Mol Med. 2014;20:137–42.\nBiglari S, Le TYL, Tan RP, Wise SG, Zambon A, Codolo G, De Bernard M, Warkiani M, Schindeler A, Naficy S, et al. Simulating inflammation in a wound microenvironment using a dermal wound-on-a-chip model. Adv Healthc Mater. 2019;8:e1801307.\nCha BH, Shin SR, Leijten J, Li YC, Singh S, Liu JC, Annabi N, Abdi R, Dokmeci MR, Vrana NE et al. Integrin-mediated interactions control macrophage polarization in 3D hydrogels. Adv Healthc Mater. 2017;6.",{"EN":185},"Chronic diabetic wounds are primarily caused by infection, inflammation, and angiogenesis-related disorders. An ideal approach for treating chronic diabetic wounds is by combining anti-infection strategies, immune microenvironment regulation, and angiogenesis promotion. Vascular endothelial growth factor (VEGF) can promote the proliferation and migration of vascular endothelial cells, thereby promoting angiogenesis. However, the low stability and inability to target lesions limit its application. Polymorphonuclear neutrophil-derived exosomes (PMNExo) exhibit good delivery properties and can be used for the therapeutic delivery of VEGF. Furthermore, they retain the antibacterial ability of polymorphonuclear neutrophils (PMNs). Nonetheless, low PMNExo generation impedes its therapeutic applications. In this study, we prepared exosome mimetics (EM) from PMNs using the extrusion process; as a result, exosome yield significantly improved. To increase the residence of exosomes, an extracellular matrix (ECM) hydrogel, a thermosensitive material that can function as an in situ gel in vivo, was used as an exosome carrier. The active peptides in the ECM regulated the immune microenvironment of the wound. In summary, we loaded ECM with VEGF-encapsulated activated neutrophil exosome mimetics (aPMNEM) to develop VEGF–aPMNEM–ECM hybrid hydrogel for treating chronic wounds. The hydrogel accelerates the regeneration of chronic diabetic wounds. Our study provides a prospective therapy platform involving cytokines for treating different diseases. \n                  \n                    \n                  \n                ",{"EN":187},"An injectable, activated neutrophil-derived exosome mimetics\u002Fextracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound 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Medical University, Soochow, China",{},{"id":266,"sortIndex":157,"affiliation":267,"properties":274},"a6051e49-8c1f-46e0-b84e-dca79fa3df3e",{"id":268,"createTime":269,"updateTime":269,"relativeEntities":270,"slug":18,"properties":271,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"f74e1e27-3bd6-4923-bdb1-16bf66a891d3","2024-01-09T23:57:00.379+00:00",[],{"title":272},{"VI":273},"Gusu School, Nanjing Medical University, Soochow, China",{},{"title":276},{"VI":277},"Bingwei 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T, et al. Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. Proc Natl Acad Sci. 2009;106:14990–5.\nGabriel D, Dvir T, Kohane DS. Delivering bioactive molecules as instructive cues to engineered tissues. Expert Opin Drug Deliv. 2012;9:473–92.\nFreeman I, Cohen S. The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization. Biomaterials. 2009;30:2122–31.\nDe la Riva B, et al. Local controlled release of VEGF and PDGF from a combined brushite-chitosan system enhances bone regeneration. J Control Release. 2010;143:45–52.\nFleischer S, Shapira A, Feiner R, Dvir T. Modular assembly of thick multifunctional cardiac patches. Proc Natl Acad Sci USA. 2017;114:1898–903.\nPerets A, et al. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res A. 2003;65:489–97.\nTimko BP, Dvir T, Kohane DS. Remotely triggerable drug delivery systems. Adv Mater. 2010;22:4925–43.\nFeiner R, Fleischer S, Shapira A, Kalish O, Dvir T. Multifunctional degradable electronic scaffolds for cardiac tissue engineering. J Control Release. 2018;281:189–95.\nShapira A, Feiner R, Dvir T. Composite biomaterial scaffolds for cardiac tissue engineering. Int Mater Rev. 2016;61:1–19.\nLim JJ, et al. Development of nano-and microscale chondroitin sulfate particles for controlled growth factor delivery. Acta Biomater. 2011;7:986–95.\nFeiner R, et al. Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function. Nat Mater. 2016;2:90.\nMalki M, Fleischer S, Shapira A, Dvir T. Gold nanorod-based engineered cardiac patch for suture-free engraftment by near IR. Nano Lett. 2018;18:4069–73.\nDvir T, et al. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011;6:720–5.\nZmora S, Glicklis R, Cohen S. Tailoring the pore architecture in 3-D alginate scaffolds by controlling the freezing regime during fabrication. Biomaterials. 2002;23:4087–94.\nFleischer S, Shevach M, Feiner R, Dvir T. Coiled fiber scaffolds embedded with gold nanoparticles improve the performance of engineered cardiac tissues. Nanoscale. 2014;6:9410–4.\nShevach M, Fleischer S, Shapira A, Dvir T. Gold nanoparticle-decellularized matrix hybrids for cardiac tissue engineering. Nano Lett. 2014;14:5792–6.\nShilo M, et al. Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction. Adv Sci. 2021;8:24.\nAiuti A, Webb I, Bleul C, Springer T, Gutierrez-Ramos J. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med. 1997;185:111–20.\nShevach M, et al. Omentum ECM-based hydrogel as a platform for cardiac cell delivery. Biomed Mater. 2015;10:034106.",{"EN":361},"Controlled release systems are often integrated into polymeric scaffolds to supply essential biofactors to trigger physiological processes in engineered tissues. Here, we report the modification of chondroitin sulfate (CS) electroactive polymer with gold nanorods (AuNRs) to create hybrid macroporous scaffolds for enhanced on-demand release of growth factors and cytokines. The mechanical properties, porosity and degradation of the hybrid scaffolds were evaluated, and the viability and functionality of seeded cardiac cells were assessed. Following, the ability to control the release of the enzyme lysozyme, and the cytokine, stromal cell-derived factor 1 (SDF-1) by applying electrical stimulation, was demonstrated. The AuNRs were able to increase the current through the scaffolds, providing an efficient on–off release profile of SDF-1, which resulted in higher migration of cells expressing CXCR4 receptor. Finally, the engineered scaffolds were transplanted in rats and SDF-1 was released daily by electrical stimulation, promoting blood vessel-forming cell infiltration and vascularization. We envision that gold nanoparticles and other conducting nanomaterials can be incorporated into different electroactive materials to improve their capabilities not only for tissue engineering applications, but for a variety of biomedical applications, where enhanced electrical stimulation is needed. \n                  \n                    \n                      \n                    \n                  \n                ",{"EN":363},"Chondroitin sulfate-AuNRs electroactive scaffolds for on-demand release of biofactors",{"VOID":365},"10.1186\u002Fs12951-022-01261-8","VERIFIED","Auto 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kidney injury (AKI) is a common kidney disease associated with excessive reactive oxygen species (ROS). Unfortunately, due to the low kidney targeting and undesired side effects, the existing antioxidant and anti-inflammatory drugs are unavailable for AKI management in clinic. Therefore, it’s essential to develop effective nanodrugs with high renal targeting and biocompatibility for AKI treatment. Herein, we reported a novel nanodrug for AKI treatment, utilizing poly(ursolic acid) (PUA) as a bioactive nanocarrier and resveratrol (RES) as a model drug. The PUA polymer was synthesized form ursolic acid with intrinsic antioxidant and anti-inflammatory activities, and successfully encapsulated RES through a nanoprecipitation method. Subsequently, we systemically investigated the therapeutic potential of RES-loaded PUA nanoparticles (PUA NPs@RES) against AKI. In vitro results demonstrated that PUA NPs@RES effectively scavenged ROS and provided substantial protection against H\u003Cjats:sub>2\u003C\u002Fjats:sub>O\u003Cjats:sub>2\u003C\u002Fjats:sub>-induced cellular damage. In vivo studies revealed that PUA NPs significantly improved drug accumulation in the kidneys and exhibited favorable biocompatibility. Furthermore, PUA NPs alone exhibited additional anti-inflammatory and antioxidant effect, synergistically enhancing therapeutic efficacy in AKI mouse models when combined with RES. Overall, our study successfully developed an effective nanodrug using self-therapeutic nanocarriers, presenting a promising option for the treatment of AKI.\u003C\u002Fjats:p>\n                \u003Cjats:p>\u003Cjats:bold>Graphical abstract\u003C\u002Fjats:bold>\u003C\u002Fjats:p>",{"EN":496},"Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute kidney 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Circulation. 1995;91(9):2488–96.\nChen K, Keaney JF Jr. Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease. Curr Atheroscler Rep. 2012;14(5):476–83.\nNowak WN, Deng J, Ruan XZ, Xu Q. Reactive oxygen species generation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2017;37(5):E41–52.\nWang Y, Li L, Zhao W, Dou Y, An H, Tao H, et al. Targeted therapy of atherosclerosis by a broad-spectrum reactive oxygen species scavenging nanoparticle with intrinsic anti-inflammatory activity. ACS Nano. 2018;12(9):8943–60.\nLibby P. Inflammation in atherosclerosis. Nature. 2002;420(6917):868–74.\nHsiai T, Berliner JA. Oxidative stress as a regulator of murine atherosclerosis. Curr Drug Targets. 2007;8(12):1222–9.\nHansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011;12(3):204–12.\nLibby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105(9):1135–43.\nKattoor AJ, Pothineni NVK, Palagiri D, Mehta JL. Oxidative stress in atherosclerosis. Curr Atheroscler Rep. 2017;19(11):42.\nGrebenyuk AN, Gladkikh VD. Modern condition and prospects for the development of medicines towards prevention and early treatment of radiation damage. Biol Bull. 2019;46(11):1540–55.\nHansson GK, Libby P. The immune response in atherosclerosis: A double-edged sword. Nat Rev Immunol. 2006;6(7):508–19.\nChan CKW, Zhang L, Cheng CK, Yang H, Huang Y, Tian XY, et al. Recent advances in managing atherosclerosis via nanomedicine. Small. 2018;14(4):1702793.\nBejarano J, Navarro-Marquez M, Morales-Zavala F, Morales JO, Garcia-Carvajal I, Araya-Fuentes E, et al. Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches. Theranostics. 2018;8(17):4710–32.\nZhang J, Zu Y, Dhanasekara CS, Li J, Wu D, Fan Z, et al. Detection and treatment of atherosclerosis using nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017;9(1):e1412.\nKim M, Sahu A, Kim GB, Nam GH, Um W, Shin SJ, et al. Comparison of in vivo targeting ability between cRGD and collagen-targeting peptide conjugated nano-carriers for atherosclerosis. J Control Release. 2018;269:337–46.\nSu T, Wang Y-B, Han D, Wang J, Qi S, Gao L, et al. Multimodality imaging of angiogenesis in a rabbit atherosclerotic model by GEBP11 peptide targeted nanoparticles. Theranostics. 2017;7(19):4791–804.\nRuehm SG, Corot C, Vogt P, Kolb S, Debatin JF. Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation. 2001;103(3):415–22.\nZhao J, Gao W, Cai X, Xu J, Zou D, Li Z, et al. Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease. Theranostics. 2019;9(10):2843–55.\nZhao J, Cai X, Gao W, Zhang L, Zou D, Zheng Y, et al. Prussian blue nanozyme with multienzyme activity reduces colitis in mice. ACS Appl Mater Interfaces. 2018;10(31):26108–17.\nZhang W, Hu S, Yin J-J, He W, Lu W, Ma M, et al. Prussian blue nanoparticles as multienzyme mimetics and reactive oxygen species scavengers. J Am Chem Soc. 2016;138(18):5860–5.\nFeng L, Dou C, Xia Y, Li B, Zhao M, Yu P, et al. Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery. ACS Nano. 2021;15(2):2263–80.\nHou W, Ye C, Chen M, Gao W, Xie X, Wu J, et al. Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis. Bioact Mater. 2021;6(8):2439–51.\nTan J, Duan X, Zhang F, Ban X, Mao J, Cao M, et al. Theranostic nanomedicine for synergistic chemodynamic therapy and chemotherapy of orthotopic glioma. Adv Sci. 2020;7(24):2003036.\nChen Q, Liang C, Sun XQ, Chen JW, Yang ZJ, Zhao H, et al. H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay. Proc Natl Acad Sci U S A. 2017;114(21):5343–8.\nJin X, Qu H, Zhu C, Jing L, Yu T. Advances of function of Prussian blue nano-materials in cancer diagnosis and therapy. J Biomed Eng. 2016;33(6):1209–13.\nCai X, Ma M, Chen H, Shi J, Ma M, Chen H, et al. Progress of applications of the Prussian blue in cancer diagnosis and therapy. Sci Technol Rev. 2016;34(2):18–26.\nZhang K, Fang Y, He Y, Yin H, Guan X, Pu Y, et al. Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence. Nat Commun. 2019;10:5380.\nCai X, Zhang K, Xie X, Zhu X, Feng J, Jin Z, et al. Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline. Biomaterials. 2020;231:119678.\nZhang K, Tu M, Gao W, Cai X, Song F, Chen Z, et al. Hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell apoptosis. Nano Lett. 2019;19(5):2812–23.\nXie X, Zhao J, Gao W, Chen J, Hu B, Cai X, et al. Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs\u002FNF-kappa B signaling pathway. Theranostics. 2021;11(7):3213–28.\nGuan X, Yin H-H, Xu X-H, Xu G, Zhang Y, Zhou B-G, et al. Tumor metabolism-engineered composite nanoplatforms potentiate sonodynamic therapy via reshaping tumor microenvironment and facilitating electron-hole pairs’ separation. Adv Funct Mater. 2020;30(27):2000326.\nYin Y, Jiang X, Sun L, Li H, Su C, Zhang Y, et al. Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma. Nano Today. 2021;36:101009.\nZhang K, Cheng Y, Ren W, Sun L, Liu C, Wang D, et al. Coordination-responsive longitudinal relaxation tuning as a versatile MRI sensing protocol for malignancy targets. Adv Sci. 2018;5(9):1800021.\nMi P, Kokuryo D, Cabral H, Wu H, Terada Y, Saga T, et al. A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy. Nat Nanotechnol. 2016;11(8):724–30.",{"EN":893},"As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It has been extensively accepted that oxidative stress and inflammation closely correlate with the evolution of atherosclerotic plaques, and they directly participate in all stages of atherosclerosis. Regarding this, anti-oxidation or anti-inflammation drugs were developed to enable anti-oxidative therapy and anti-inflammation therapy against atherosclerosis. However, current drugs failed to meet clinical demands. Nanomedicine and nanotechnology hold great potential in addressing the issue. In this report, we engineered a simvastatin (Sim)-loaded theranostic agent based on porous manganese-substituted prussian blue (PMPB) analogues. The biomimetic PMPB carrier could scavenge ROS and mitigate inflammation in vitro and in vivo. Especially after combining with Sim, the composite Sim@PMPB NC was expected to regulate the processes of atherosclerosis. As well, Mn2+ release from PMPB was expected to enhance MRI. The composite Sim@PMPB NC performed the best in regulating the hallmarks of atherosclerosis with above twofold decreases, typically such as oxidative stress, macrophage infiltration, plaque density, LDL internalization, fibrous cap thickness and foam cell birth, etc. Moreover, H2O2-induced Mn2+ release from PMPB NC in atherosclerotic inflammation could enhance MRI for visualizing plaques. Moreover, Sim@PMPB exhibited high biocompatibility according to references and experimental results. The biomimetic Sim@PMPB theranostic agent successfully stabilized atherosclerotic plaques and alleviated atherosclerosis, and also localized and magnified atherosclerosis, which enabled the monitoring of H2O2-associated atherosclerosis evolution after treatment. As well, Sim@PMPB was biocompatible, thus holding great potential in clinical translation for treating atherosclerosis. \n                  \n                    \n                      \n                    \n                  \n                ",{"EN":895},"Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis",{"VOID":897},"10.1186\u002Fs12951-021-00897-2","https:\u002F\u002Fjnanobiotechnology.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12951-021-00897-2",[900,917,932,944,956,968,983,995,1007,1019],{"id":901,"sortIndex":158,"researcher":18,"roles":902,"affiliations":903,"properties":914},"a435fccd-7810-4f2b-913f-b686914e05da",[196],[904],{"id":18,"sortIndex":19,"affiliation":905,"properties":18},{"id":906,"createTime":907,"updateTime":908,"relativeEntities":909,"slug":910,"properties":911,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"00977f44-9fcb-43b0-9c2b-6fae24546af0","2024-01-13T07:54:24.219+00:00","2025-06-11T14:05:20.240+00:00",[],"Department-of-Medical-Ultrasound-and-Central-Laboratory-Shanghai-Tenth-People-s-Hospital-Ultrasound-Research-and-Education-Institute-Clinical-Research-Center-for-Interventional-Medicine-Tongji-University-School-of-Medicine-Shanghai-Engineering-Research-Center-of-Ultrasound-Diagnosis-and-Treatment-National-Clinical-Research-Center-for-Interventional-Medicine-Shanghai-People-s-Republic-of-China",{"title":912},{"VI":913},"Department of Medical Ultrasound and Central Laboratory, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Clinical Research Center for Interventional Medicine, Tongji University School of Medicine, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, National Clinical Research Center for Interventional Medicine, Shanghai, People’s Republic of China",{"title":915},{"VI":916},"Haohao Yin",{"id":918,"sortIndex":247,"researcher":18,"roles":919,"affiliations":920,"properties":929},"cf35db84-85bb-41bd-848e-bf5bb56dac82",[196],[921],{"id":18,"sortIndex":19,"affiliation":922,"properties":18},{"id":923,"createTime":924,"updateTime":924,"relativeEntities":925,"slug":18,"properties":926,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"9d0fe889-52df-4e20-958b-aabf53d3bfb2","2023-12-20T14:21:37.694+00:00",[],{"title":927},{"VI":928},"Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, People’s Republic of China",{"title":930},{"VI":931},"Chunxia Su",{"id":933,"sortIndex":159,"researcher":18,"roles":934,"affiliations":935,"properties":941},"b30811f8-3d9f-42a5-89b3-174463b265a8",[196],[936],{"id":18,"sortIndex":19,"affiliation":937,"properties":18},{"id":906,"createTime":907,"updateTime":908,"relativeEntities":938,"slug":910,"properties":939,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":940},{"VI":913},{"title":942},{"VI":943},"Liping Sun",{"id":945,"sortIndex":87,"researcher":18,"roles":946,"affiliations":947,"properties":953},"58fd8422-5528-4a6c-bbf9-900b0dd6b8c2",[196],[948],{"id":18,"sortIndex":19,"affiliation":949,"properties":18},{"id":906,"createTime":907,"updateTime":908,"relativeEntities":950,"slug":910,"properties":951,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":952},{"VI":913},{"title":954},{"VI":955},"Huixiong Xu",{"id":957,"sortIndex":156,"researcher":18,"roles":958,"affiliations":959,"properties":965},"19d9d35e-c7cb-4c89-97a6-5844a536ffa3",[196],[960],{"id":18,"sortIndex":19,"affiliation":961,"properties":18},{"id":906,"createTime":907,"updateTime":908,"relativeEntities":962,"slug":910,"properties":963,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":964},{"VI":913},{"title":966},{"VI":967},"Hongyan Li",{"id":969,"sortIndex":157,"researcher":18,"roles":970,"affiliations":971,"properties":980},"f47efc06-6227-47bb-a123-eb027e40b890",[196],[972],{"id":18,"sortIndex":19,"affiliation":973,"properties":18},{"id":974,"createTime":975,"updateTime":975,"relativeEntities":976,"slug":18,"properties":977,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"358059d3-28c2-4cd1-8bea-dab0c8c74692","2023-12-07T08:03:43.852+00:00",[],{"title":978},{"VI":979},"Department of Radiology, Affiliated Hospital of Guilin Medical University, Guilin, People’s Republic of China",{"title":981},{"VI":982},"Wei Zhang",{"id":984,"sortIndex":613,"researcher":18,"roles":985,"affiliations":986,"properties":992},"5dd8020e-7240-4c92-a670-f45b533c9b4a",[196],[987],{"id":18,"sortIndex":19,"affiliation":988,"properties":18},{"id":906,"createTime":907,"updateTime":908,"relativeEntities":989,"slug":910,"properties":990,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":991},{"VI":913},{"title":993},{"VI":994},"Kun 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Yin",{"id":1008,"sortIndex":155,"researcher":18,"roles":1009,"affiliations":1010,"properties":1016},"22b08fa1-6c54-4b07-b0a6-05067021408a",[196],[1011],{"id":18,"sortIndex":19,"affiliation":1012,"properties":18},{"id":906,"createTime":907,"updateTime":908,"relativeEntities":1013,"slug":910,"properties":1014,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1015},{"VI":913},{"title":1017},{"VI":1018},"Taixia Wang",{"id":1020,"sortIndex":19,"researcher":18,"roles":1021,"affiliations":1022,"properties":1028},"8f442776-8c00-4917-9a6a-e6c1750db313",[196],[1023],{"id":18,"sortIndex":19,"affiliation":1024,"properties":18},{"id":906,"createTime":907,"updateTime":908,"relativeEntities":1025,"slug":910,"properties":1026,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1027},{"VI":913},{"title":1029},{"VI":1030},"Yan Zhang",{"url":898,"publisher":1032,"properties":1059},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1033,"slug":10,"properties":1034,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1037,"manageAffiliations":1038,"indexDatabases":1039,"url":146,"thumbnailPath":18,"statistic":1054,"gsStatistic":18,"type":172,"analyzePriority":18},[],{"issn":1035,"title":1036},{"VOID":13},{"EN":15},[],[],[1040,1047],{"id":127,"indexDatabase":1041,"url":142,"indexYears":18,"academicFieldIds":1046,"indexDatabaseRanking":18},{"id":129,"createTime":130,"updateTime":131,"relativeEntities":1042,"label":1043,"description":1044,"key":138,"publicationTags":1045,"standard":18},[],{"EN":134,"VI":134},{"VI":136,"EN":137},[140,141],[144,145],{"id":102,"indexDatabase":1048,"url":115,"indexYears":116,"academicFieldIds":1053,"indexDatabaseRanking":125},{"id":104,"createTime":105,"updateTime":106,"relativeEntities":1049,"label":1050,"description":1051,"key":112,"publicationTags":1052,"standard":18},[],{"EN":109,"VI":109},{"EN":109,"VI":111},[114],[118,119,120,121,122,123,124],{"impactFactor":19,"impactFactorByYear":1055,"i10Index":98,"i10IndexLast5Year":19,"totalPublication":153,"totalPublicationByYear":1056,"totalCitation":160,"totalCitationByYear":1057,"totalCitationPerPublication":166,"totalCitationPerPublicationByYear":1058,"hindexLast5Year":98,"hindex":98},{"2012":149,"2013":150,"2014":150,"2015":151,"2016":152},{"2003":150,"2004":155,"2007":156,"2010":156,"2011":157,"2013":155,"2014":157,"2015":150,"2017":150,"2019":150,"2020":157,"2021":155,"2022":158,"2023":159,"2024":150},{"2007":162,"2010":163,"2011":159,"2013":164,"2014":165},{"2007":168,"2010":169,"2011":156,"2013":170,"2014":171},{"volume":1060,"pages":1062},{"VOID":1061},"19",{"VOID":1063},"1-13","2021-05-31",2021,{"id":1067,"createTime":1068,"updateTime":1069,"relativeEntities":1070,"slug":1071,"properties":1072,"entityType":190,"verifyStatus":17,"verifyTime":1069,"verifyNote":1081,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1082,"fullTextUrl":18,"authors":1083,"publicationType":314,"publisherRelationship":1190,"citationCount":18,"citationInfo":18,"publishDate":1222,"publishYear":1223,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":350},"9c71c2c9-3ccd-4817-8eed-890f512cee8d","2024-02-21T10:45:33.755+00:00","2024-12-24T23:54:22.013+00:00",[],"N-hexanoyl-chitosan-stabilized-magnetic-nanoparticles-Implication-for-cellular-labeling-and-magnetic-resonance-imaging",{"references":1073,"abstract":1075,"title":1077,"doi":1079},{"VOID":1074},"Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, Wu MT, Shieh DB: Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications. Biomaterials. 2005, 26: 729-738. 10.1016\u002Fj.biomaterials.2004.03.016.\nPankhurst QA, Connolly J, Jones SK, Dobson J: Applications of magnetic nanoparticles in biomedicine. J Phys D-Appl Phys. 2003, 36: 167-181. 10.1088\u002F0022-3727\u002F36\u002F13\u002F201.\nKhor E, Lim LY: Implantable applications of chitin and chitosan. Biomaterials. 2003, 24: 2339-2349. 10.1016\u002FS0142-9612(03)00026-7.\nGupta AK, Berry C, Gupta M, Curtis A: Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis. IEEE Trans Nanobiosci. 2003, 2: 256-261. 10.1109\u002FTNB.2003.820279.\nWoo K, Hong J, Choi S, Lee HW, Ahn JP, Kim CS, Lee SW: Easy synthesis and magnetic properties of iron oxide nanoparticles. Chem Mater. 2004, 16: 2814-2818. 10.1021\u002Fcm049552x.\nLee HS, Kim EH, Shao H, Kwak BK: Synthesis of SPIO-chitosan microspheres for MRI-detectable embolotherapy. J Magn Magn Mater. 2005, 293: 102-105. 10.1016\u002Fj.jmmm.2005.01.049.\nRemant Bahadur KC, Aryal S, Bhattarai SR, Bhattarai N, Kim CH, Kim HY: Stabilization of gold nanoparticles by hydrophobically-modified polycations. J Biomater Sci Polym Ed. 2006, 17 (5): 579-589. 10.1163\u002F156856206776986279.\nBhattarai SR, Kc RB, Aryal S, Bhattarai N, Kim SY, Lee HY, Hwang PH, Kim HY: Hydrophobically modified chitoan\u002Fgold nanoparticles for DNA delivery. J Nanopart Res. 2008, 10: 151-162. 10.1007\u002Fs11051-007-9233-7.\nBhattarai SR, Kc RB, Aryal S, Khil MS, Kim HY: N-Acylated chitosan stabilized iron oxide nanoparticles as a novel nano-matrix and ceramic modification. Carbo Polym. 2007, 69: 467-477. 10.1016\u002Fj.carbpol.2007.01.006.\nKim DK, Mikhaylova M, Zhang Y, Muhammed M: Protective coating of superparamagnetic iron oxide nanoparticles. Chem Mater. 2003, 15: 1617-1627. 10.1021\u002Fcm021349j.\nArbab AS, Wilson BL, Ashari P, Jordan EK, Lewis BK, Frank JA: A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging. NMR Biomed. 2005, 18: 383-389. 10.1002\u002Fnbm.970.\nBhattarai SR, Kim SY, Jang KY, Yi HK, Lee YH, Bhattarai N, Nam SY, Lee DY, Kim HY, Hwang PH: Amphiphilic Triblock Copolymer Poly (p-Dioxanone-co-L-Lactide)-block-Poly (ethylene glycol), Enhancement of Gene Expression and Inhibition of Lung Metastasis by Aerosol Delivery. Gene Ther. 2007, 14: 476-483. 10.1038\u002Fsj.gt.3302876.\nBhattarai SR, Yi HK, Bhattarai N, Hwang PH, Kim HY: Novel Block Copolymer (PDO\u002FLLA-b-PEG-); Enhancement of DNA Uptake and Cell Transfection. Acta Biomaterialia. 2006, 2: 207-212. 10.1016\u002Fj.actbio.2005.10.007.",{"EN":1076},"This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37°C. Nearly 8.53 ± 0.31 pg iron\u002Fcell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields.",{"EN":1078},"N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging",{"VOID":1080},"10.1186\u002F1477-3155-6-1","Author affiliation is blank","https:\u002F\u002Fjnanobiotechnology.biomedcentral.com\u002Farticles\u002F10.1186\u002F1477-3155-6-1",[1084,1091,1106,1121,1136,1151,1163,1178],{"id":1085,"sortIndex":158,"researcher":18,"roles":1086,"affiliations":1087,"properties":1088},"7e596a5f-7e3a-4fc6-ba24-4e87a5216e1c",[196],[],{"title":1089},{"VI":1090},"Pyoung H Hwang",{"id":1092,"sortIndex":247,"researcher":18,"roles":1093,"affiliations":1094,"properties":1103},"4eff8941-bcde-4c1d-83db-c7423483b452",[196],[1095],{"id":18,"sortIndex":19,"affiliation":1096,"properties":18},{"id":1097,"createTime":1098,"updateTime":1098,"relativeEntities":1099,"slug":18,"properties":1100,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"801e1dd3-9459-411b-ad7e-6379307a46b9","2024-02-21T10:45:33.828+00:00",[],{"title":1101},{"VI":1102},"Department of Textile Engineering, Chonbuk National Univiversity, Jeonju, South Korea",{"title":1104},{"VI":1105},"Hak Y Kim",{"id":1107,"sortIndex":150,"researcher":18,"roles":1108,"affiliations":1109,"properties":1118},"76f4c86a-7b2b-41e8-ab53-eabe08d5443b",[196],[1110],{"id":18,"sortIndex":19,"affiliation":1111,"properties":18},{"id":1112,"createTime":1113,"updateTime":1113,"relativeEntities":1114,"slug":18,"properties":1115,"entityType":86,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"5024be5e-3d25-49a6-8737-75c5060e79b7","2024-02-21T10:45:33.780+00:00",[],{"title":1116},{"VI":1117},"Department of Bionanosystem Engineering, Chonbuk National Univiversity, Jeonju, South Korea",{"title":1119},{"VI":1120},"Remant B 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ME, Mallampalli RK, Horowitz JC. Pathogenesis of pneumonia and acute lung injury. Clin Sci. 2022;136:747–69.\nBice T, Li G, Malinchoc M, Lee AS, Gajic O. Incidence and risk factors of recurrent acute lung injury. Crit Care Med. 2011;39:1069–73.\nDushianthan A, Grocott MP, Postle AD, Cusack R. Acute respiratory distress syndrome and acute lung injury. Postgrad Med J. 2011;87:612–22.\nMatthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Investig. 2012;122:2731–40.\nMatthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5:18.\nHabashi NM, Camporota L, Gatto LA, Nieman G. Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications. J Appl Physiol (1985). 2021;130:877–91.\nTimin AS, Postovalova AS, Karpov TE, Antuganov D, Bukreeva AS, Akhmetova DR, Rogova AS, Muslimov AR, Rodimova SA, Kuznetsova DS, Zyuzin MV. Calcium carbonate carriers for combined chemo- and radionuclide therapy of metastatic lung cancer. J Control Release. 2022;344:1–11.\nSkotland T, Iversen TG, Llorente A, Sandvig K. Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: possibilities and challenges. Adv Drug Deliv Rev. 2022;186:114326.\nChan WCW. Principles of nanoparticle delivery to solid tumors. BME Front. 2023;4:0016.\nWang B, He X, Zhang Z, Zhao Y, Feng W. Metabolism of nanomaterials in vivo: blood circulation and organ clearance. Acc Chem Res. 2013;46:761–9.\nKumar M, Kulkarni P, Liu S, Chemuturi N, Shah DK. Nanoparticle biodistribution coefficients: a quantitative approach for understanding the tissue distribution of nanoparticles. Adv Drug Deliv Rev. 2023;194:114708.\nKnust J, Ochs M, Gundersen HJ, Nyengaard JR. Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs. Anat Rec (Hoboken). 2009;292:113–22.\nForest V, Pourchez J. Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient? Adv Drug Deliv Rev. 2022;183:114173.\nPark JY, Park S, Lee TS, Hwang YH, Kim JY, Kang WJ, Key J. Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system. Biomaterials. 2019;218:119331.\nBruinink A, Wang J, Wick P. Effect of particle agglomeration in nanotoxicology. Arch Toxicol. 2015;89:659–75.\nBolla G, Sarma B, Nangia AK. Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved drugs. Chem Rev. 2022;122:11514–603.\nDesiraju GR. Crystal engineering: from molecule to crystal. J Am Chem Soc. 2013;135:9952–67.\nBolla G, Sarma B, Nangia AK. Chap. 5 - Crystal engineering and pharmaceutical crystallization. In Hot Topics in Crystal Engineering Edited by Rissanen K: Elsevier; 2021: 157–229.\nMandpe P, Prabhakar B, Shende P. 23 full factorial design for optimization of stable amorphous host–guest-based mirabegron complex for extended-release action. J Inclusion Phenom Macrocycl Chem. 2020;96:111–23.\nCid-Samamed A, Rakmai J, Mejuto JC, Simal-Gandara J, Astray G. Cyclodextrins inclusion complex: Preparation methods, analytical techniques and food industry applications. Food Chem. 2022;384:132467.\nJi X, Wu D, Li C, Li JL, Sun Q, Chang DW, Yin QX, Zhou LN, Xie C, Gong JB, Chen W. Enhanced solubility, dissolution, and permeability of Abacavir by Salt and Cocrystal formation. Cryst Growth Des. 2022;22:428–40.\nChen D, Huang W, Zhang Q, Zhang Z, Guo Y, Vreeman G, Sun CC, Hawley M, Yang B-S, He X. Bioavailability-enhancing cocrystals: screening, in vivo predictive dissolution, and Supersaturation maintenance. Cryst Growth Des. 2022;22:5154–67.\nWei YF, Zhang L, Wang NN, Shen PY, Dou HT, Ma K, Gao Y, Zhang JJ, Qian S. Mechanistic study on Complexation-Induced Spring and Hover Dissolution Behavior of Ibuprofen-Nicotinamide Cocrystal. Cryst Growth Des. 2018;18:7343–55.\nBavishi DD, Borkhataria CH. Spring and parachute: how cocrystals enhance solubility. Prog Cryst Growth Charact Mater. 2016;62:1–8.\nHeng WL, He XS, Song YT, Han JW, Pang ZT, Qian S, Zhang JJ, Gao Y, Wei YF. Insights into cocrystallization and Coamorphization Engineering Techniques in the delivery of traditional Chinese medicine: formation mechanism, solid-state characterization, and Improved Pharmaceutical properties. Cryst Growth Des. 2022;22:5110–34.\nNagoor Meeran MF, Goyal SN, Suchal K, Sharma C, Patil CR, Ojha SK. Pharmacological properties, Molecular mechanisms, and Pharmaceutical Development of Asiatic Acid: a Pentacyclic Triterpenoid of Therapeutic Promise. Front Pharmacol. 2018;9:892.\nMa K, Zhang Y, Zhu D, Lou Y. Protective effects of asiatic acid against D-galactosamine\u002Flipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. Eur J Pharmacol. 2009;603:98–107.\nYun KJ, Kim JY, Kim JB, Lee KW, Jeong SY, Park HJ, Jung HJ, Cho YW, Yun K, Lee KT. Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. Int Immunopharmacol. 2008;8:431–41.\nXu X, Si L, Xu J, Yi C, Wang F, Gu W, Zhang Y, Wang X. Asiatic acid inhibits cardiac hypertrophy by blocking interleukin-1beta-activated nuclear factor-kappab signaling in vitro and in vivo. J Thorac Dis. 2015;7:1787–97.\nLi Z, Xiao X, Yang M. Asiatic Acid inhibits Lipopolysaccharide-Induced Acute Lung Injury in mice. Inflammation. 2016;39:1642–8.\nSun B, Wu L, Wu Y, Zhang C, Qin L, Hayashi M, Kudo M, Gao M, Liu T. Therapeutic potential of Centella asiatica and its triterpenes: a review. Front Pharmacol. 2020;11:568032.\nYuan Y, Zhang H, Sun F, Sun S, Zhu Z, Chai Y. Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC-MS method. J Ethnopharmacol. 2015;163:31–8.\nZhang YW, Tu LL, Zhang Y, Pan JC, Zheng GL, Yin LN. Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis. Drug Deliv. 2021;28:2534–47.\nDubey A, Dhas N, Naha A, Rani U, Gs R, Shetty A, C RS, Hebbar S. Cationic biopolymer decorated Asiatic Acid and Centella asiatica extract incorporated liposomes for treating early-stage Alzheimer’s disease: An In-vitro and In-vivo investigation. F1000Res 2022, 11:1535.\nHe S, Wu L, Sun H, Wu D, Wang C, Ren X, Shao Q, York P, Tong J, Zhu J, et al. Antioxidant biodegradable covalent cyclodextrin frameworks as Particulate Carriers for Inhalation Therapy against Acute Lung Injury. ACS Appl Mater Interfaces. 2022;14:38421–35.\nYuan R, Li Y, Han S, Chen X, Chen J, He J, Gao H, Yang Y, Yang S, Yang Y. Fe-Curcumin nanozyme-mediated reactive oxygen species scavenging and anti-inflammation for Acute Lung Injury. ACS Cent Sci. 2022;8:10–21.\nSweeney RM, Griffiths M, McAuley D. Treatment of acute lung injury: current and emerging pharmacological therapies. Semin Respir Crit Care Med. 2013;34:487–98.\nBabu NJ, Nangia A. Solubility advantage of amorphous drugs and Pharmaceutical cocrystals. Cryst Growth Des. 2011;11:2662–79.\nChilds SL, Kandi P, Lingireddy SR. Formulation of a Danazol Cocrystal with Controlled Supersaturation plays an essential role in improving bioavailability. Mol Pharm. 2013;10:3112–27.\nBanik M, Gopi SP, Ganguly S, Desiraju GR. Cocrystal and Salt forms of Furosemide: solubility and diffusion variations. Cryst Growth Des. 2016;16:5418–28.",{"EN":1234},"",{"EN":1236},"Acute lung injury (ALI) is a fatal respiratory disease caused by overreactive immune reactions (e.g., SARS-CoV-2 infection), with a high mortality rate. Its treatment is often compromised by inefficient drug delivery barriers and insufficient potency of the currently used drugs. Therefore, developing a highly effective lung-targeted drug delivery strategy is a pressing clinical need. In this study, the micro-sized inclusion cocrystal of asiatic acid\u002Fγ-cyclodextrin (AA\u002FγCD, with a stoichiometry molar ratio of 2:3 and a mean size of 1.8 μm) was prepared for ALI treatment. The dissolution behavior of the AA\u002FγCD inclusion cocrystals followed a “spring-and-hover” model, which meaned that AA\u002FγCD could dissolve from the cocrystal in an inclusion complex form, thereby promoting a significantly improved water solubility (nine times higher than free AA). This made the cyclodextrin-based inclusion cocrystals an effective solid form for enhanced drug absorption and delivery efficiency. The biodistribution experiments demonstrated AA\u002FγCD accumulated predominantly in the lung (Cmax = 50 µg\u002Fg) after systemic administration due to the micron size-mediated passive targeting effect. The AA\u002FγCD group showed an enhanced anti-inflammatory therapeutic effect, as evidenced by reduced levels of pro-inflammatory cytokines in the lung and bronchoalveolar lavage fluids (BALF). Histological examination confirmed that AA\u002FγCD effectively inhibited inflammation reactions. The micro-sized inclusion cocrystals AA\u002FγCD were successfully delivered into the lungs by pulmonary administration and had a significant therapeutic effect on ALI. \n                  \n                    \n                  \n                ",{"EN":1238},"Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy 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Doare K, Holder B, Bassett A, Pannaraj PS. 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Nature. 2018;564:130–5.\nStelter P, Ulrich HD. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature. 2003;425:188–91.\nGoel P, Manning JA, Kumar S. NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins. Gene. 2015;557:1–10.\nDing Y, Zhang Y, Xu C, Tao QH, Chen YG. HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates wnt signaling by targeting dishevelled for proteasomal degradation. J Biol Chem. 2013;288:8289–98.\nNielsen CP, Jernigan KK, Diggins NL, Webb DJ, MacGurn JA. USP9X deubiquitylates DVL2 to regulate wnt pathway specification. Cell Rep. 2019;28:1074–89.",{"EN":1402},"The intestinal development in early life is profoundly influenced by multiple biological components of breast milk, in which milk-derived extracellular vesicles (mEVs) contain a large amount of vertically transmitted signal from the mother. However, little is known about how maternal fiber-rich diet regulates offspring intestinal development by influencing the mEVs. In this study, we found that maternal resistant starch (RS) consumption during late gestation and lactation improved the growth and intestinal health of offspring. The mEVs in breast milk are the primary factor driving these beneficial effects, especially enhancing intestinal cell proliferation and migration. To be specific, administration of mEVs after maternal RS intake enhanced intestinal cell proliferation and migration in vivo (performed in mice model and indicated by intestinal histological observation, EdU assay, and the quantification of cyclin proteins) and in vitro (indicated by CCK8, MTT, EdU, and wound healing experiments). Noteworthily, miR-146a-5p was found to be highly expressed in the mEVs from maternal RS group, which also promotes intestinal cell proliferation in cells and mice models. Mechanically, miR-146a-5p target to silence the expression of ubiquitin ligase 3 gene NEDD4L, thereby inhibiting DVL2 ubiquitination, activating the Wnt pathway, and promoting intestinal development. These findings demonstrated the beneficial role of mEVs in the connection between maternal fiber rich diet and offspring intestinal growth. In addition, we identified a novel miRNA-146a-5p-NEDD4L-β-catenin\u002FWnt signaling axis in regulating early intestinal development. This work provided a new perspective for studying the influence of maternal diet on offspring development. \n                  \n                    \n                  \n                ",{"EN":1404},"Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying 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SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life. 2019;12:10.\nGreenwood-Van B, Meerveld G, Pharmacology, editors.Springer International Publishing, Cham, Vol. 239, 2017.\nCai Z, Wang S, Li J. Treatment of inflammatory bowel disease: a Comprehensive Review. Front Med. 2021;8:765474.\nSairenji T, Collins KL, Evans DV. An update on inflammatory bowel disease. Prim Care. 2017;44:673–92.\nRaine T, Bonovas S, Burisch J, Kucharzik T, Adamina M, Annese V, et al. ECCO Guidelines on therapeutics in Ulcerative Colitis: Medical Treatment. J Crohn’s and Colitis. 2022;16:2–17.\nCunliffe RN, Scott BB. Review article：monitoring for drug side-effects in inflammatory bowel disease. Aliment Pharmacol Ther. 2002;16:647–62.\nAshton JJ, Green Z, Kolimarala V, Beattie RM. Inflammatory bowel disease: long-term therapeutic challenges. Expert Rev Gastroenterol Hepatol. 2019;13:1049–63.\nAntonino RSCMQ, Nascimento TL, de Oliveira Junior ER, Souza LG, Batista AC, Lima EM. Thermoreversible mucoadhesive polymer-drug dispersion for sustained local delivery of budesonide to treat inflammatory disorders of the GI tract. J Controlled Release. 2019;303:12–23.\nDate AA, Halpert G, Babu T, Ortiz J, Kanvinde P, Dimitrion P, et al. Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease. Biomaterials. 2018;185:97–105.\nHanauer SB, Robinson M, Pruitt R, Lazenby AJ, Persson T, Nilsson LG, et al. Budesonide enema for the treatment of active, distal ulcerative colitis and proctitis: a dose-ranging study. Gastroenterology. 1998;115:525–32.\nAmidon S, Brown JE, Dave VS. Colon-targeted oral drug Delivery Systems: Design Trends and Approaches. AAPS PharmSciTech. 2015;16:731–41.\nEckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. Diversity of the human intestinal Microbial Flora. Science. 2005;308:1635–8.\nFroidurot A, Julliand V. Cellulolytic bacteria in the large intestine of mammals. Gut Microbes. 2022;14:2031694.\nMacy JM, Farrand JR, Montgomery L. Cellulolytic and non-cellulolytic bacteria in rat gastrointestinal tracts. Appl Environ Microbiol. 1982;44:1428–34.\nWu Q-X, Guan Y-X, Yao S-J. Sodium cellulose sulfate: A promising biomaterial used for microcarriers’ designing. Front. Chem. Sci. Eng. 2019;13:46–58.\nZhang Q, Lin D, Yao S. Review on biomedical and bioengineering applications of cellulose sulfate. Carbohydr Polym. 2015;132:311–22.\nMendoza-Muñoz N, Urbán-Morlán Z, Leyva-Gómez G, Zambrano-Zaragoza M, de la ¨Piñón-Segundo L, Quintanar-Guerrero E. Solid lipid nanoparticles: an Approach to improve oral drug delivery. J Pharm Pharm Sci. 2021;24:509–32.\nSalah E, Abouelfetouh MM, Pan YH, Chen DM, Xie SY. Solid lipid nanoparticles for enhanced oral absorption: A review. Colloids Surf. B. 2020;196:111305.\nSchwarz C, Mehnert W, Lucks JS, Müller RH. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J Controlled Release. 1994;30:83–96.\nCollnot E-M, Ali H, Lehr C-M. Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa. J Controlled Release. 2012;161:235–46.\nHua S, Marks E, Schneider JJ, Keely S. Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue. Nanomedicine. 2015;11:1117–32.\nAmasya G, Bakar-Ates F, Wintgens V, Amiel C. Layer by layer assembly of core-corona structured solid lipid nanoparticles with β-cyclodextrin polymers. Int J Pharm. 2021;592:119994.\nNaeem M, Oshi MA, Kim J, Lee J, Cao J, Nurhasni H, et al. pH-triggered surface charge-reversal nanoparticles alleviate experimental murine colitis via selective accumulation in inflamed colon regions. Nanomedicine. 2018;14:823–34.\nLi JF, Yang JS. Synthesis of folate mediated carboxymethyl cellulose fatty acid ester and application in drug controlled release. Carbohydr Polym. 2019;220:126–31.\nSakellari GI, Zafeiri I, Batchelor H, Spyropoulos F. Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the encapsulation of a model hydrophobic active. Food Hydrocoll Health. 2021;1:100024.\nBantchev G, Lu ZH, Lvov Y. Layer-by-layer Nanoshell Assembly on Colloids through simplified Washless process. J Nanosci Nanotech. 2009;9:396–403.\nSantos AC, Sequeira JAD, Pereira I, Cabral C, Collado Gonzallez M, Fontes-Ribeiro C, et al. Sonication-assisted layer-by-layer self-assembly nanoparticles for resveratrol delivery. Mater Sci Eng C. 2019;105:110022.\nZhu L-Y, Lin D-Q, Yao S-J. Biodegradation of polyelectrolyte complex films composed of chitosan and sodium cellulose sulfate as the controllable release carrier. Carbohydr Polym. 2010;82:323–8.\nWoraphatphadung T, Sajomsang W, Rojanarata T, Ngawhirunpat T, Tonglairoum P, Opanasopit P. Development of Chitosan-Based pH-Sensitive polymeric Micelles containing curcumin for Colon-targeted drug delivery. AAPS PharmSciTech. 2018;19:991–1000.\nDeshavath NN, Mukherjee G, Goud VV, Veeranki VD, Sastri CV. Pitfalls in the 3, 5-dinitrosalicylic acid (DNS) assay for the reducing sugars: interference of furfural and 5-hydroxymethylfurfural. Macromol. 2020;156:180–5.\nWirtz S, Popp V, Kindermann M, Gerlach K, Weigmann B, Fichtner-Feigl S, et al. Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc. 2017;12:1295–309.\nChung CH, Jung W, Keum H, Kim TW, Jon S. Nanoparticles derived from the natural antioxidant Rosmarinic Acid ameliorate Acute Inflammatory Bowel Disease. ACS Nano. 2020;14:6887–96.\nAbdalla MI, Herfarth H. Budesonide for the treatment of ulcerative colitis. Expert Opin on Pharmacotherapy. 2016;17:1549–59.\nNasirizadeh S, Malaekeh-Nikouei B. Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery. J Drug Delivery Sci Technol. 2020;55:101458.\nBasha SK, Dhandayuthabani R, Muzammil MS, Kumari VS. Solid lipid nanoparticles for oral drug delivery. Materials Today: Proceedings. 2021;36:313–24.\nYaghmur A, Mu H. Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles. Acta Pharm Sin B. 2021;11:871–85.\nAli H, Weigmann B, Neurath MF, Collnot EM, Windbergs M, Lehr C-M. Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases. J Controlled Release. 2014;183:167–77.\nSangalli ME, Maroni A, Zema L, Busetti C, Giordano F, Gazzaniga A. In vitro and in vivo evaluation of an oral system for time and\u002For site-specific drug delivery. J Controlled Release. 2001;73:103–10.\nFallingborg J, Christensen LA, Jacobsen BA, Rasmussen SN. Very low intraluminal colonic pH in patients with active ulcerative colitis. Digest Dis Sci. 1993;38:1989–93.\nCui MX, Zhang M, Liu K. Colon-targeted drug delivery of polysaccharide-based nanocarriers for synergistic treatment of inflammatory bowel disease: a review. Carbohydr Polym. 2021;272:118530.\nTirosh B, Khatib N, Barenholz Y, Nissan A, Rubinstein A. Transferrin as a Luminal Target for negatively charged Liposomes in the Inflamed Colonic Mucosa. Mol Pharm. 2009;6:1083–91.\nNaeem M, Choi M, Cao J, Lee Y, Lkram M, Yoon S et al. Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy. DDDT. 2015;3789.\nFriend DR. New oral delivery systems for treatment of inflammatory bowel disease. Adv Drug Deliv Rev. 2005;57:247–65.\nAndreica B-I, Cheng XJ, Marin L. Quaternary ammonium salts of chitosan. A critical overview on the synthesis and properties generated by quaternization. Eur. Polym. J. 2020;139:110016.\nBorges J, Mano JF. Molecular interactions driving the layer-by-Layer Assembly of Multilayers. Chem Rev. 2014;114:8883–942.\nFinke JH, Schmolke H, Klages C-P, Müller-Goymann CC. Controlling solid lipid nanoparticle adhesion by polyelectrolyte multilayer surface modifications. Int J Pharm. 2013;449:59–71.\nLin C-H, Chen C-H, Lin Z-C, Fang J-Y. Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. J Food Drug Anal. 2017;25:219–34.\nKulkarni N, Jain P, Shindikar A, Suryawanshi P, Thorat N. Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease. Carbohydr Polym. 2022;288:119351.\nPeterson CGB, Eklund E, Taha Y, Raab Y, Carlson M. A New Method for the quantification of Neutrophil and Eosinophil Cationic Proteins in feces: establishment of normal levels and clinical application in patients with inflammatory bowel disease. Am J Gastroenterol. 2002;97:8.\nSchmitz H, Barmeyer C, Fromm M, Runkel N, Foss H-D, Bentzel CJ, et al. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology. 1999;116:301–9.\nLamprecht A. Selective nanoparticle adhesion can enhance colitis therapy. Nat Rev Gastroenterol Hepatol. 2010;7:311–2.",{"EN":1612},"Colon-targeted oral drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC), which is a disease with high relapse and remission rates associated with immune system inflammation and dysregulation localized within the lining of the large bowel. However, the success of current available approaches used for colon-targeted therapy is limited. Budesonide (BUD) is a corticosteroid drug, and its rectal and oral formulations are used to treat UC, but the inconvenience of rectal administration and the systemic toxicity of oral administration restrict its long-term use. In this study, we designed and prepared colon-targeted solid lipid nanoparticles (SLNs) encapsulating BUD to treat UC by oral administration. A negatively charged surfactant (NaCS-C12) was synthesized to anchor cellulase-responsive layers consisting of polyelectrolyte complexes (PECs) formed by negatively charged NaCS and cationic chitosan onto the SLNs. The release rate and colon-specific release behavior of BUD could be easily modified by regulating the number of coated layers. We found that the two-layer BUD-loaded SLNs (SLN-BUD-2L) with a nanoscale particle size and negative zeta potential showed the designed colon-specific drug release profile in response to localized high cellulase activity. In addition, SLN-BUD-2L exhibited excellent anti-inflammatory activity in a dextran sulfate sodium (DSS)-induced colitis mouse model, suggesting its potential anti-UC applications.",{"EN":1614},"Surface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling colonic budesonide release for ulcerative colitis 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However, the extremely low abundance imposes stringent requirements for accurate detection techniques. In this study, a novel, protease-free DNA amplification strategy, known as “Rolling Hoop Orbital Amplification” (RHOA), was initially developed based on the design concept of local reaction and inspired by the childhood game of rolling iron ring. Benefiting from the local space constructed by the DNA orbital, the circular DNA enzyme rolls directionally and interacts efficiently with the amplification element, making it nearly 3-fold more productive than conventional free-diffusion amplification. Similarly, the localized cascade nanozyme catalytic system formed by bridging DNA probes also exhibits outperformed than free ones. Therefore, a localized energized high-performance electrochemiluminescence (ECL) biosensor was constructed by bridging cascading nanozymes on the electrode surface through DNA probes generated by RHOA, with an impressive limit of detection (LOD) of 1.5 aM for the detection of exosomal miRNA15a-5p and a stable linearity over a wide concentration range from 10− 2 to 108 fM. Thus, this work is a focused attempt at the localized reaction, which is expected to provide a reliable method for accurately detecting of exo-miRNAs.",{"EN":1831},"Dancing in local space: rolling hoop orbital amplification combined with local cascade nanozyme catalytic system to achieve ultra-sensitive detection of exosomal 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ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer progression. Extracellular vesicles (EVs), including exosomes and microvesicles, help facilitate an exchange of information both within the TME and to distant organs. EVs have also been identified as potential diagnostic biomarkers, therapeutic targets, and drug carriers for pancreatic cancer treatment. Thus, understanding the selective packaging of EVs cargo and its mechanistic impact will increase our understanding of cancer biology. In this review, we collect and analyze recent findings of the pancreatic cancer-stromal cell interactions mediated by EVs and the mechanisms involved in cancer-related immunity and chemoresistance. These studies demonstrate the vital role of EVs in pancreatic cancer reprogramming and TME remodeling. We also summarize the EVs identified as potential PDAC diagnostic biomarkers and possible therapeutic targets. This greater understanding is a promising avenue for transitioning EVs from bench to bedside.\u003C\u002Fjats:p>\u003Cjats:p>\u003Cjats:bold>Graphical Abstract\u003C\u002Fjats:bold>\u003C\u002Fjats:p>",{"EN":2047},"Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor 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